BindingDB logo
myBDB logout

Patent code US9682961

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Wnt/beta-Catenin


(Homo sapiens)
BDBM143712
PNG
(US9682961, 1)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc[nH]c4c3)nc12
Show InChI InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148385
PNG
(US9682961, 31)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1c(Br)ccc2cnc(Nc3ccc4nc[nH]c4c3)nc12
Show InChI InChI=1S/C21H20BrN5O2/c22-16-7-1-12-10-23-21(26-13-2-8-17-18(9-13)25-11-24-17)27-19(12)20(16)29-15-5-3-14(28)4-6-15/h1-2,7-11,14-15,28H,3-6H2,(H,24,25)(H,23,26,27)/t14-,15+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148380
PNG
(US9682961, 29)
Show SMILES OCc1cc(Nc2ncc3cccc(O[C@@H]4CC[C@H](O)CC4)c3n2)cc2[nH]cnc12
Show InChI InChI=1S/C22H23N5O3/c28-11-14-8-15(9-18-20(14)25-12-24-18)26-22-23-10-13-2-1-3-19(21(13)27-22)30-17-6-4-16(29)5-7-17/h1-3,8-10,12,16-17,28-29H,4-7,11H2,(H,24,25)(H,23,26,27)/t16-,17+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148359
PNG
(US9682961, 13)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4[nH]c(CN5CCCC5)nc4c3)nc12
Show InChI InChI=1S/C26H30N6O2/c33-19-7-9-20(10-8-19)34-23-5-3-4-17-15-27-26(31-25(17)23)28-18-6-11-21-22(14-18)30-24(29-21)16-32-12-1-2-13-32/h3-6,11,14-15,19-20,33H,1-2,7-10,12-13,16H2,(H,29,30)(H,27,28,31)/t19-,20+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148401
PNG
(US9682961, 43)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1c(F)ccc2cnc(Nc3ccc4ncccc4c3)nc12
Show InChI InChI=1S/C23H21FN4O2/c24-19-9-3-15-13-26-23(27-16-4-10-20-14(12-16)2-1-11-25-20)28-21(15)22(19)30-18-7-5-17(29)6-8-18/h1-4,9-13,17-18,29H,5-8H2,(H,26,27,28)/t17-,18+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148400
PNG
(US9682961, 42)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1c(F)ccc2cnc(Nc3ccc4ncsc4c3)nc12
Show InChI InChI=1S/C21H19FN4O2S/c22-16-7-1-12-10-23-21(25-13-2-8-17-18(9-13)29-11-24-17)26-19(12)20(16)28-15-5-3-14(27)4-6-15/h1-2,7-11,14-15,27H,3-6H2,(H,23,25,26)/t14-,15+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148391
PNG
(US9682961, 37)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccnc4ccccc34)nc12
Show InChI InChI=1S/C23H22N4O2/c28-16-8-10-17(11-9-16)29-21-7-3-4-15-14-25-23(27-22(15)21)26-20-12-13-24-19-6-2-1-5-18(19)20/h1-7,12-14,16-17,28H,8-11H2,(H,24,25,26,27)/t16-,17+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148402
PNG
(US9682961, 44)
Show SMILES OCc1n[nH]c2cc(Nc3ncc4ccc(F)c(O[C@@H]5CC[C@H](O)CC5)c4n3)ccc12
Show InChI InChI=1S/C22H22FN5O3/c23-17-8-1-12-10-24-22(25-13-2-7-16-18(9-13)27-28-19(16)11-29)26-20(12)21(17)31-15-5-3-14(30)4-6-15/h1-2,7-10,14-15,29-30H,3-6,11H2,(H,27,28)(H,24,25,26)/t14-,15+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148390
PNG
(US9682961, 36)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4scnc4c3)nc12
Show InChI InChI=1S/C21H20N4O2S/c26-15-5-7-16(8-6-15)27-18-3-1-2-13-11-22-21(25-20(13)18)24-14-4-9-19-17(10-14)23-12-28-19/h1-4,9-12,15-16,26H,5-8H2,(H,22,24,25)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148404
PNG
(US9682961, 46)
Show SMILES COc1ccc2c(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)ccnc2c1
Show InChI InChI=1S/C24H24N4O3/c1-30-18-9-10-19-20(11-12-25-21(19)13-18)27-24-26-14-15-3-2-4-22(23(15)28-24)31-17-7-5-16(29)6-8-17/h2-4,9-14,16-17,29H,5-8H2,1H3,(H,25,26,27,28)/t16-,17+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148399
PNG
(US9682961, 41)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3cccc4cnccc34)nc12
Show InChI InChI=1S/C23H22N4O2/c28-17-7-9-18(10-8-17)29-21-6-2-4-16-14-25-23(27-22(16)21)26-20-5-1-3-15-13-24-12-11-19(15)20/h1-6,11-14,17-18,28H,7-10H2,(H,25,26,27)/t17-,18+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148386
PNG
(US9682961, 32)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cc(F)cc2cnc(Nc3ccc4nc[nH]c4c3)nc12
Show InChI InChI=1S/C21H20FN5O2/c22-13-7-12-10-23-21(26-14-1-6-17-18(9-14)25-11-24-17)27-20(12)19(8-13)29-16-4-2-15(28)3-5-16/h1,6-11,15-16,28H,2-5H2,(H,24,25)(H,23,26,27)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148360
PNG
(US9682961, 14)
Show SMILES OCc1nc2cc(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)ccc2[nH]1
Show InChI InChI=1S/C22H23N5O3/c28-12-20-25-17-9-4-14(10-18(17)26-20)24-22-23-11-13-2-1-3-19(21(13)27-22)30-16-7-5-15(29)6-8-16/h1-4,9-11,15-16,28-29H,5-8,12H2,(H,25,26)(H,23,24,27)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148384
PNG
(US9682961, 30)
Show SMILES Cc1cc2nc[nH]c2cc1Nc1ncc2cccc(O[C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C22H23N5O2/c1-13-9-18-19(25-12-24-18)10-17(13)26-22-23-11-14-3-2-4-20(21(14)27-22)29-16-7-5-15(28)6-8-16/h2-4,9-12,15-16,28H,5-8H2,1H3,(H,24,25)(H,23,26,27)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148364
PNG
(US9682961, 17)
Show SMILES Cc1ccc2cnc(Nc3ccc4nc[nH]c4c3)nc2c1O[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H23N5O2/c1-13-2-3-14-11-23-22(26-15-4-9-18-19(10-15)25-12-24-18)27-20(14)21(13)29-17-7-5-16(28)6-8-17/h2-4,9-12,16-17,28H,5-8H2,1H3,(H,24,25)(H,23,26,27)/t16-,17+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148389
PNG
(US9682961, 35)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4ncccc4c3)nc12
Show InChI InChI=1S/C23H22N4O2/c28-18-7-9-19(10-8-18)29-21-5-1-3-16-14-25-23(27-22(16)21)26-17-6-11-20-15(13-17)4-2-12-24-20/h1-6,11-14,18-19,28H,7-10H2,(H,25,26,27)/t18-,19+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148376
PNG
(US9682961, 25)
Show SMILES COCc1nc2ccc(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)cc2[nH]1
Show InChI InChI=1S/C23H25N5O3/c1-30-13-21-26-18-10-5-15(11-19(18)27-21)25-23-24-12-14-3-2-4-20(22(14)28-23)31-17-8-6-16(29)7-9-17/h2-5,10-12,16-17,29H,6-9,13H2,1H3,(H,26,27)(H,24,25,28)/t16-,17+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148368
PNG
(US9682961, 20)
Show SMILES Cc1nc2c(C)cc(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)cc2[nH]1
Show InChI InChI=1S/C23H25N5O2/c1-13-10-16(11-19-21(13)26-14(2)25-19)27-23-24-12-15-4-3-5-20(22(15)28-23)30-18-8-6-17(29)7-9-18/h3-5,10-12,17-18,29H,6-9H2,1-2H3,(H,25,26)(H,24,27,28)/t17-,18+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148365
PNG
(US9682961, 18)
Show SMILES Cc1nc2ccc(Nc3ncc4ccc(Br)c(O[C@@H]5CC[C@H](O)CC5)c4n3)cc2[nH]1
Show InChI InChI=1S/C22H22BrN5O2/c1-12-25-18-9-3-14(10-19(18)26-12)27-22-24-11-13-2-8-17(23)21(20(13)28-22)30-16-6-4-15(29)5-7-16/h2-3,8-11,15-16,29H,4-7H2,1H3,(H,25,26)(H,24,27,28)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148396
PNG
(US9682961, 39)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4cnccc4c3)nc12
Show InChI InChI=1S/C23H22N4O2/c28-19-6-8-20(9-7-19)29-21-3-1-2-17-14-25-23(27-22(17)21)26-18-5-4-16-13-24-11-10-15(16)12-18/h1-5,10-14,19-20,28H,6-9H2,(H,25,26,27)/t19-,20+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148393
PNG
(US9682961, 38)
Show SMILES Cc1ccc2cc(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)ccc2n1
Show InChI InChI=1S/C24H24N4O2/c1-15-5-6-16-13-18(7-12-21(16)26-15)27-24-25-14-17-3-2-4-22(23(17)28-24)30-20-10-8-19(29)9-11-20/h2-7,12-14,19-20,29H,8-11H2,1H3,(H,25,27,28)/t19-,20+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148378
PNG
(US9682961, 27)
Show SMILES C[C@H](O)c1nc2ccc(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)cc2[nH]1
Show InChI InChI=1S/C23H25N5O3/c1-13(29)22-26-18-10-5-15(11-19(18)27-22)25-23-24-12-14-3-2-4-20(21(14)28-23)31-17-8-6-16(30)7-9-17/h2-5,10-13,16-17,29-30H,6-9H2,1H3,(H,26,27)(H,24,25,28)/t13-,16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148403
PNG
(US9682961, 45)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccnc4cc(F)ccc34)nc12
Show InChI InChI=1S/C23H21FN4O2/c24-15-4-9-18-19(10-11-25-20(18)12-15)27-23-26-13-14-2-1-3-21(22(14)28-23)30-17-7-5-16(29)6-8-17/h1-4,9-13,16-17,29H,5-8H2,(H,25,26,27,28)/t16-,17+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148397
PNG
(US9682961, 40)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4ccncc4c3)nc12
Show InChI InChI=1S/C23H22N4O2/c28-19-6-8-20(9-7-19)29-21-3-1-2-16-14-25-23(27-22(16)21)26-18-5-4-15-10-11-24-13-17(15)12-18/h1-5,10-14,19-20,28H,6-9H2,(H,25,26,27)/t19-,20+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148366
PNG
(US9682961, 19)
Show SMILES Cc1nc2c(Br)cc(Nc3ncc4cccc(O[C@@H]5CC[C@H](O)CC5)c4n3)cc2[nH]1
Show InChI InChI=1S/C22H22BrN5O2/c1-12-25-18-10-14(9-17(23)21(18)26-12)27-22-24-11-13-3-2-4-19(20(13)28-22)30-16-7-5-15(29)6-8-16/h2-4,9-11,15-16,29H,5-8H2,1H3,(H,25,26)(H,24,27,28)/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens)
BDBM148377
PNG
(US9682961, 26)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc([nH]c4c3)C(F)(F)F)nc12
Show InChI InChI=1S/C22H20F3N5O2/c23-22(24,25)20-28-16-9-4-13(10-17(16)29-20)27-21-26-11-12-2-1-3-18(19(12)30-21)32-15-7-5-14(31)6-8-15/h1-4,9-11,14-15,31H,5-8H2,(H,28,29)(H,26,27,30)/t14-,15+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%