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Patent code US9682965

Compile Data Set for Download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148438
PNG
(US9682965, 3)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCCC2)C1
Show InChI InChI=1S/C26H42N2O5/c1-18(2)7-8-21-25(3,33-21)23-22(30-4)20(9-11-26(23)17-31-26)32-24(29)28-15-19(16-28)10-14-27-12-5-6-13-27/h7,19-23H,5-6,8-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152670
PNG
(US9682965, 88)
Show SMILES CCN(CC)CCNC(=O)CCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C29H49N3O6/c1-7-31(8-2)16-15-30-24(33)12-10-21-17-32(18-21)27(34)37-22-13-14-29(19-36-29)26(25(22)35-6)28(5)23(38-28)11-9-20(3)4/h9,21-23,25-26H,7-8,10-19H2,1-6H3,(H,30,33)/t22-,23-,25-,26-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152144
PNG
(US9682965, 54)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@H](CCN2CCOCC2)C1
Show InChI InChI=1S/C27H44N2O6/c1-19(2)5-6-22-26(3,35-22)24-23(31-4)21(7-10-27(24)18-33-27)34-25(30)29-12-9-20(17-29)8-11-28-13-15-32-16-14-28/h5,20-24H,6-18H2,1-4H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148449
PNG
(US9682965, 6)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC(O)C2)C1
Show InChI InChI=1S/C25H40N2O6/c1-16(2)5-6-20-24(3,33-20)22-21(30-4)19(7-9-25(22)15-31-25)32-23(29)27-11-17(12-27)8-10-26-13-18(28)14-26/h5,17-22,28H,6-15H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150755
PNG
(US9682965, 49)
Show SMILES CCN(CC)CCC1(O)CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C26H44N2O6/c1-7-27(8-2)14-13-25(30)15-28(16-25)23(29)33-19-11-12-26(17-32-26)22(21(19)31-6)24(5)20(34-24)10-9-18(3)4/h9,19-22,30H,7-8,10-17H2,1-6H3/t19-,20-,21-,22-,24+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152147
PNG
(US9682965, 56)
Show SMILES CCN(CC)CC[C@@H]1CCN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152664
PNG
(US9682965, 84)
Show SMILES CNC(=O)NC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C22H35N3O6/c1-13(2)6-7-16-21(3,31-16)18-17(28-5)15(8-9-22(18)12-29-22)30-20(27)25-10-14(11-25)24-19(26)23-4/h6,14-18H,7-12H2,1-5H3,(H2,23,24,26)/t15-,16-,17-,18-,21+,22+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152583
PNG
(US9682965, 73)
Show SMILES CCN(CC)CCNC(=O)OC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H45N3O7/c1-7-29(8-2)14-13-28-24(31)35-19-15-30(16-19)25(32)36-20-11-12-27(17-34-27)23(22(20)33-6)26(5)21(37-26)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3,(H,28,31)/t20-,21-,22-,23-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152682
PNG
(US9682965, 103)
Show SMILES CCN(CC)CCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)14-12-19-15-28(16-19)24(29)32-20-11-13-26(17-31-26)23(22(20)30-6)25(5)21(33-25)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148451
PNG
(US9682965, 8)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCC(C)(O)CC2)C1
Show InChI InChI=1S/C28H46N2O6/c1-19(2)6-7-22-27(4,36-22)24-23(33-5)21(8-10-28(24)18-34-28)35-25(31)30-16-20(17-30)9-13-29-14-11-26(3,32)12-15-29/h6,20-24,32H,7-18H2,1-5H3/t21-,22-,23-,24-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148452
PNG
(US9682965, 9)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC(C)(O)C2)C1
Show InChI InChI=1S/C26H42N2O6/c1-17(2)6-7-20-25(4,34-20)22-21(31-5)19(8-10-26(22)16-32-26)33-23(29)28-12-18(13-28)9-11-27-14-24(3,30)15-27/h6,18-22,30H,7-16H2,1-5H3/t19-,20-,21-,22-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148450
PNG
(US9682965, 7)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCC(O)CC2)C1
Show InChI InChI=1S/C27H44N2O6/c1-18(2)5-6-22-26(3,35-22)24-23(32-4)21(7-11-27(24)17-33-27)34-25(31)29-15-19(16-29)8-12-28-13-9-20(30)10-14-28/h5,19-24,30H,6-17H2,1-4H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152311
PNG
(US9682965, 59)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCCN2CCCC2)C1
Show InChI InChI=1S/C27H44N2O5/c1-19(2)9-10-22-26(3,34-22)24-23(31-4)21(11-12-27(24)18-32-27)33-25(30)29-16-20(17-29)8-7-15-28-13-5-6-14-28/h9,20-24H,5-8,10-18H2,1-4H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150799
PNG
(US9682965, 52)
Show SMILES CCN(CC)CCC1CCN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20?,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152571
PNG
(US9682965, 61)
Show SMILES CCN(CC)CCCC1(O)CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O6/c1-7-28(8-2)15-9-13-26(31)16-29(17-26)24(30)34-20-12-14-27(18-33-27)23(22(20)32-6)25(5)21(35-25)11-10-19(3)4/h10,20-23,31H,7-9,11-18H2,1-6H3/t20-,21-,22-,23-,25+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152582
PNG
(US9682965, 72)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)OC(N)=O
Show InChI InChI=1S/C21H32N2O7/c1-12(2)5-6-15-20(3,30-15)17-16(26-4)14(7-8-21(17)11-27-21)29-19(25)23-9-13(10-23)28-18(22)24/h5,13-17H,6-11H2,1-4H3,(H2,22,24)/t14-,15-,16-,17-,20+,21+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148442
PNG
(US9682965, 4)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCCCC2)C1
Show InChI InChI=1S/C27H44N2O5/c1-19(2)8-9-22-26(3,34-22)24-23(31-4)21(10-12-27(24)18-32-27)33-25(30)29-16-20(17-29)11-15-28-13-6-5-7-14-28/h8,20-24H,5-7,9-18H2,1-4H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148444
PNG
(US9682965, 5)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCC2)C1
Show InChI InChI=1S/C25H40N2O5/c1-17(2)6-7-20-24(3,32-20)22-21(29-4)19(8-10-25(22)16-30-25)31-23(28)27-14-18(15-27)9-13-26-11-5-12-26/h6,18-22H,5,7-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148457
PNG
(US9682965, 16)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC3(COC3)C2)C1
Show InChI InChI=1S/C27H42N2O6/c1-18(2)5-6-21-25(3,35-21)23-22(31-4)20(7-9-27(23)17-33-27)34-24(30)29-11-19(12-29)8-10-28-13-26(14-28)15-32-16-26/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,27+/m1/s1
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US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152686
PNG
(US9682965, 121)
Show SMILES CCNCCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C24H40N2O5/c1-6-25-12-10-17-13-26(14-17)22(27)30-18-9-11-24(15-29-24)21(20(18)28-5)23(4)19(31-23)8-7-16(2)3/h7,17-21,25H,6,8-15H2,1-5H3/t18-,19-,20-,21-,23+,24+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152758
PNG
(US9682965, 122)
Show SMILES CCNC[C@@H]1CCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C23H38N2O5/c1-6-24-13-16-10-12-25(16)21(26)29-17-9-11-23(14-28-23)20(19(17)27-5)22(4)18(30-22)8-7-15(2)3/h7,16-20,24H,6,8-14H2,1-5H3/t16-,17+,18+,19+,20+,22-,23-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150800
PNG
(US9682965, 53)
Show SMILES CCN(CC)CC[C@H]1CCN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148432
PNG
(US9682965, 1)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCOCC2)C1
Show InChI InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152574
PNG
(US9682965, 63)
Show SMILES CNC(=O)CC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C23H36N2O6/c1-14(2)6-7-17-22(3,31-17)20-19(28-5)16(8-9-23(20)13-29-23)30-21(27)25-11-15(12-25)10-18(26)24-4/h6,15-17,19-20H,7-13H2,1-5H3,(H,24,26)/t16-,17-,19-,20-,22+,23+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152584
PNG
(US9682965, 74)
Show SMILES CNC(=O)OC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C22H34N2O7/c1-13(2)6-7-16-21(3,31-16)18-17(27-5)15(8-9-22(18)12-28-22)30-20(26)24-10-14(11-24)29-19(25)23-4/h6,14-18H,7-12H2,1-5H3,(H,23,25)/t15-,16-,17-,18-,21+,22+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148472
PNG
(US9682965, 22)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC3C(C2)C3(F)F)C1
Show InChI InChI=1S/C27H40F2N2O5/c1-16(2)5-6-21-25(3,36-21)23-22(33-4)20(7-9-26(23)15-34-26)35-24(32)31-11-17(12-31)8-10-30-13-18-19(14-30)27(18,28)29/h5,17-23H,6-15H2,1-4H3/t18?,19?,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152760
PNG
(US9682965, 124)
Show SMILES CCNCCCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C25H42N2O5/c1-6-26-13-7-8-18-14-27(15-18)23(28)31-19-11-12-25(16-30-25)22(21(19)29-5)24(4)20(32-24)10-9-17(2)3/h9,18-22,26H,6-8,10-16H2,1-5H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152759
PNG
(US9682965, 123)
Show SMILES CCNC[C@H]1CCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C23H38N2O5/c1-6-24-13-16-10-12-25(16)21(26)29-17-9-11-23(14-28-23)20(19(17)27-5)22(4)18(30-22)8-7-15(2)3/h7,16-20,24H,6,8-14H2,1-5H3/t16-,17-,18-,19-,20-,22+,23+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152575
PNG
(US9682965, 65)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CC(N)=O)C1
Show InChI InChI=1S/C22H34N2O6/c1-13(2)5-6-16-21(3,30-16)19-18(27-4)15(7-8-22(19)12-28-22)29-20(26)24-10-14(11-24)9-17(23)25/h5,14-16,18-19H,6-12H2,1-4H3,(H2,23,25)/t15-,16-,18-,19-,21+,22+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152578
PNG
(US9682965, 68)
Show SMILES CCN(CC)CCNC(=O)OCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C28H47N3O7/c1-7-30(8-2)14-13-29-25(32)35-17-20-15-31(16-20)26(33)37-21-11-12-28(18-36-28)24(23(21)34-6)27(5)22(38-27)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3,(H,29,32)/t21-,22-,23-,24-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152573
PNG
(US9682965, 62)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CC(=O)N2CCOCC2)C1
Show InChI InChI=1S/C26H40N2O7/c1-17(2)5-6-20-25(3,35-20)23-22(31-4)19(7-8-26(23)16-33-26)34-24(30)28-14-18(15-28)13-21(29)27-9-11-32-12-10-27/h5,18-20,22-23H,6-16H2,1-4H3/t19-,20-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152576
PNG
(US9682965, 66)
Show SMILES CCN(CC)CCNC(=O)CC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C28H47N3O6/c1-7-30(8-2)14-13-29-23(32)15-20-16-31(17-20)26(33)36-21-11-12-28(18-35-28)25(24(21)34-6)27(5)22(37-27)10-9-19(3)4/h9,20-22,24-25H,7-8,10-18H2,1-6H3,(H,29,32)/t21-,22-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM149586
PNG
(US9682965, 40)
Show SMILES CCN(CC)C[C@@H]1CCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C25H42N2O5/c1-7-26(8-2)15-18-12-14-27(18)23(28)31-19-11-13-25(16-30-25)22(21(19)29-6)24(5)20(32-24)10-9-17(3)4/h9,18-22H,7-8,10-16H2,1-6H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM149588
PNG
(US9682965, 41)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@H]1CN1CCCC1
Show InChI InChI=1S/C25H40N2O5/c1-17(2)7-8-20-24(3,32-20)22-21(29-4)19(9-11-25(22)16-30-25)31-23(28)27-14-10-18(27)15-26-12-5-6-13-26/h7,18-22H,5-6,8-16H2,1-4H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152676
PNG
(US9682965, 91)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCC2CCN(CC(F)F)CC2)C1
Show InChI InChI=1S/C29H46F2N2O5/c1-19(2)5-8-23-28(3,38-23)26-25(35-4)22(9-12-29(26)18-36-29)37-27(34)33-15-21(16-33)7-6-20-10-13-32(14-11-20)17-24(30)31/h5,20-26H,6-18H2,1-4H3/t22-,23-,25-,26-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148454
PNG
(US9682965, 11)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCN(C)C(=O)C2)C1
Show InChI InChI=1S/C27H43N3O6/c1-18(2)6-7-21-26(3,36-21)24-23(33-5)20(8-10-27(24)17-34-27)35-25(32)30-14-19(15-30)9-11-29-13-12-28(4)22(31)16-29/h6,19-21,23-24H,7-17H2,1-5H3/t20-,21-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148474
PNG
(US9682965, 31)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2C3CCC2COC3)C1
Show InChI InChI=1S/C28H44N2O6/c1-18(2)5-8-23-27(3,36-23)25-24(32-4)22(9-11-28(25)17-34-28)35-26(31)29-13-19(14-29)10-12-30-20-6-7-21(30)16-33-15-20/h5,19-25H,6-17H2,1-4H3/t20?,21?,22-,23-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152570
PNG
(US9682965, 60)
Show SMILES CCN(CC)C[C@H]1CCCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)16-19-10-9-15-28(19)24(29)32-20-13-14-26(17-31-26)23(22(20)30-6)25(5)21(33-25)12-11-18(3)4/h11,19-23H,7-10,12-17H2,1-6H3/t19-,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150750
PNG
(US9682965, 48)
Show SMILES CCN(CC)C[C@@H]1CCCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)16-19-10-9-15-28(19)24(29)32-20-13-14-26(17-31-26)23(22(20)30-6)25(5)21(33-25)12-11-18(3)4/h11,19-23H,7-10,12-17H2,1-6H3/t19-,20+,21+,22+,23+,25-,26-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150798
PNG
(US9682965, 51)
Show SMILES CCN(CC)CC[C@@H]1CCCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)17-14-20-10-9-16-29(20)25(30)33-21-13-15-27(18-32-27)24(23(21)31-6)26(5)22(34-26)12-11-19(3)4/h11,20-24H,7-10,12-18H2,1-6H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150542
PNG
(US9682965, 42)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H]1CN1CCCC1
Show InChI InChI=1S/C25H40N2O5/c1-17(2)7-8-20-24(3,32-20)22-21(29-4)19(9-11-25(22)16-30-25)31-23(28)27-14-10-18(27)15-26-12-5-6-13-26/h7,18-22H,5-6,8-16H2,1-4H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152146
PNG
(US9682965, 55)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H](CCN2CCOCC2)C1
Show InChI InChI=1S/C27H44N2O6/c1-19(2)5-6-22-26(3,35-22)24-23(31-4)21(7-10-27(24)18-33-27)34-25(30)29-12-9-20(17-29)8-11-28-13-15-32-16-14-28/h5,20-24H,6-18H2,1-4H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148465
PNG
(US9682965, 20)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC(C)(C2)C(=O)N(C)C)C1
Show InChI InChI=1S/C29H47N3O6/c1-19(2)8-9-22-28(4,38-22)24-23(35-7)21(10-12-29(24)18-36-29)37-26(34)32-14-20(15-32)11-13-31-16-27(3,17-31)25(33)30(5)6/h8,20-24H,9-18H2,1-7H3/t21-,22-,23-,24-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152685
PNG
(US9682965, 105)
Show SMILES CCN(CC)CC1CCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C25H42N2O5/c1-7-26(8-2)15-18-12-14-27(18)23(28)31-19-11-13-25(16-30-25)22(21(19)29-6)24(5)20(32-24)10-9-17(3)4/h9,18-22H,7-8,10-16H2,1-6H3/t18?,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150793
PNG
(US9682965, 50)
Show SMILES CCN(CC)CC[C@H]1CCCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)17-14-20-10-9-16-29(20)25(30)33-21-13-15-27(18-32-27)24(23(21)31-6)26(5)22(34-26)12-11-19(3)4/h11,20-24H,7-10,12-18H2,1-6H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM149584
PNG
(US9682965, 39)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCOCC2=O)C1
Show InChI InChI=1S/C26H40N2O7/c1-17(2)5-6-20-25(3,35-20)23-22(31-4)19(7-9-26(23)16-33-26)34-24(30)28-13-18(14-28)8-10-27-11-12-32-15-21(27)29/h5,18-20,22-23H,6-16H2,1-4H3/t19-,20-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152580
PNG
(US9682965, 69)
Show SMILES CNC(=O)OCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C23H36N2O7/c1-14(2)6-7-17-22(3,32-17)19-18(28-5)16(8-9-23(19)13-30-23)31-21(27)25-10-15(11-25)12-29-20(26)24-4/h6,15-19H,7-13H2,1-5H3,(H,24,26)/t16-,17-,18-,19-,22+,23+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152679
PNG
(US9682965, 98)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)Nc1ccccn1
Show InChI InChI=1S/C25H35N3O5/c1-16(2)8-9-19-24(3,33-19)22-21(30-4)18(10-11-25(22)15-31-25)32-23(29)28-13-17(14-28)27-20-7-5-6-12-26-20/h5-8,12,17-19,21-22H,9-11,13-15H2,1-4H3,(H,26,27)/t18-,19-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152681
PNG
(US9682965, 101)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(Cc2ccc(C)nc2)C1
Show InChI InChI=1S/C27H38N2O5/c1-17(2)6-9-22-26(4,34-22)24-23(31-5)21(10-11-27(24)16-32-27)33-25(30)29-14-20(15-29)12-19-8-7-18(3)28-13-19/h6-8,13,20-24H,9-12,14-16H2,1-5H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152159
PNG
(US9682965, 57)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@H](CCN2CC(F)(F)C2)C1
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-10-25(22)16-33-25)34-23(31)30-12-9-18(13-30)8-11-29-14-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148455
PNG
(US9682965, 13)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCC(F)(F)CC2)C1
Show InChI InChI=1S/C27H42F2N2O5/c1-18(2)5-6-21-25(3,36-21)23-22(33-4)20(7-9-26(23)17-34-26)35-24(32)31-15-19(16-31)8-12-30-13-10-27(28,29)11-14-30/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148456
PNG
(US9682965, 14)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC(C)(C2)C#N)C1
Show InChI InChI=1S/C27H41N3O5/c1-18(2)6-7-21-26(4,35-21)23-22(32-5)20(8-10-27(23)17-33-27)34-24(31)30-12-19(13-30)9-11-29-15-25(3,14-28)16-29/h6,19-23H,7-13,15-17H2,1-5H3/t20-,21-,22-,23-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148430
PNG
(US9682965, Compound A)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)\C=C\c1ccc(OCCN(C)C)cc1
Show InChI InChI=1S/C29H41NO6/c1-20(2)7-13-24-28(3,36-24)27-26(32-6)23(15-16-29(27)19-34-29)35-25(31)14-10-21-8-11-22(12-9-21)33-18-17-30(4)5/h7-12,14,23-24,26-27H,13,15-19H2,1-6H3/b14-10+/t23-,24-,26-,27-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150718
PNG
(US9682965, 44)
Show SMILES CCN(CC)CC1CN(CCO1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C26H44N2O6/c1-7-27(8-2)15-19-16-28(13-14-31-19)24(29)33-20-11-12-26(17-32-26)23(22(20)30-6)25(5)21(34-25)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3/t19?,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152680
PNG
(US9682965, 100)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(Cc2ccccn2)C1
Show InChI InChI=1S/C26H36N2O5/c1-17(2)8-9-21-25(3,33-21)23-22(30-4)20(10-11-26(23)16-31-26)32-24(29)28-14-18(15-28)13-19-7-5-6-12-27-19/h5-8,12,18,20-23H,9-11,13-16H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152581
PNG
(US9682965, 71)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)OC(=O)N1CCOCC1
Show InChI InChI=1S/C25H38N2O8/c1-16(2)5-6-19-24(3,35-19)21-20(30-4)18(7-8-25(21)15-32-25)34-23(29)27-13-17(14-27)33-22(28)26-9-11-31-12-10-26/h5,17-21H,6-15H2,1-4H3/t18-,19-,20-,21-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148458
PNG
(US9682965, 17)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCn2cccn2)C1
Show InChI InChI=1S/C25H37N3O5/c1-17(2)6-7-20-24(3,33-20)22-21(30-4)19(8-10-25(22)16-31-25)32-23(29)27-14-18(15-27)9-13-28-12-5-11-26-28/h5-6,11-12,18-22H,7-10,13-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150748
PNG
(US9682965, 45)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCC(F)(F)C2)C1
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-9-25(22)16-33-25)34-23(31)30-13-18(14-30)8-11-29-12-10-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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n/an/a 275n/an/an/an/an/an/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148477
PNG
(US9682965, 34)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCN(CC(F)F)CC2)C1
Show InChI InChI=1S/C28H45F2N3O5/c1-19(2)5-6-22-27(3,38-22)25-24(35-4)21(7-9-28(25)18-36-28)37-26(34)33-15-20(16-33)8-10-31-11-13-32(14-12-31)17-23(29)30/h5,20-25H,6-18H2,1-4H3/t21-,22-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148453
PNG
(US9682965, 10)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCS(=O)(=O)CC2)C1
Show InChI InChI=1S/C26H42N2O7S/c1-18(2)5-6-21-25(3,35-21)23-22(32-4)20(7-9-26(23)17-33-26)34-24(29)28-15-19(16-28)8-10-27-11-13-36(30,31)14-12-27/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152585
PNG
(US9682965, 78)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)OC(=O)N1CCN(C)CC1
Show InChI InChI=1S/C26H41N3O7/c1-17(2)6-7-20-25(3,36-20)22-21(32-5)19(8-9-26(22)16-33-26)35-24(31)29-14-18(15-29)34-23(30)28-12-10-27(4)11-13-28/h6,18-22H,7-16H2,1-5H3/t19-,20-,21-,22-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152577
PNG
(US9682965, 67)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCC(=O)NCCN2CCOCC2)C1
Show InChI InChI=1S/C29H47N3O7/c1-20(2)5-7-23-28(3,39-23)26-25(35-4)22(9-10-29(26)19-37-29)38-27(34)32-17-21(18-32)6-8-24(33)30-11-12-31-13-15-36-16-14-31/h5,21-23,25-26H,6-19H2,1-4H3,(H,30,33)/t22-,23-,25-,26-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148478
PNG
(US9682965, 37)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H](CN2CCOCC2)C1
Show InChI InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-10-8-19(16-28)15-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t19-,20+,21+,22+,23+,25-,26-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152191
PNG
(US9682965, 58)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H](CCN2CC(F)(F)C2)C1
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-10-25(22)16-33-25)34-23(31)30-12-9-18(13-30)8-11-29-14-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152658
PNG
(US9682965, 81)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)OC(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C27H40F3N3O7/c1-17(2)5-6-20-25(3,40-20)22-21(36-4)19(7-8-26(22)16-37-26)39-24(35)33-13-18(14-33)38-23(34)32-11-9-31(10-12-32)15-27(28,29)30/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148971
PNG
(US9682965, 38)
Show SMILES CCN(CC)C[C@H]1CCN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)15-19-12-14-28(16-19)24(29)32-20-11-13-26(17-31-26)23(22(20)30-6)25(5)21(33-25)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3/t19-,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152659
PNG
(US9682965, 82)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)OC(=O)NCC(C)(C)O
Show InChI InChI=1S/C25H40N2O8/c1-15(2)7-8-18-24(5,35-18)20-19(31-6)17(9-10-25(20)14-32-25)34-22(29)27-11-16(12-27)33-21(28)26-13-23(3,4)30/h7,16-20,30H,8-14H2,1-6H3,(H,26,28)/t17-,18-,19-,20-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152683
PNG
(US9682965, 104)
Show SMILES CCN(CC)CCCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-9-10-20-16-29(17-20)25(30)33-21-13-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)12-11-19(3)4/h11,20-24H,7-10,12-18H2,1-6H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148437
PNG
(US9682965, 2)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC(F)(F)C2)C1
Show InChI InChI=1S/C25H38F2N2O5/c1-16(2)5-6-19-23(3,34-19)21-20(31-4)18(7-9-24(21)15-32-24)33-22(30)29-11-17(12-29)8-10-28-13-25(26,27)14-28/h5,17-21H,6-15H2,1-4H3/t18-,19-,20-,21-,23+,24+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM150713
PNG
(US9682965, 43)
Show SMILES CCN(CC)C[C@H]1CCN1C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C25H42N2O5/c1-7-26(8-2)15-18-12-14-27(18)23(28)31-19-11-13-25(16-30-25)22(21(19)29-6)24(5)20(32-24)10-9-17(3)4/h9,18-22H,7-8,10-16H2,1-6H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152677
PNG
(US9682965, 95)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CN2CCOCC2)C1
Show InChI InChI=1S/C25H40N2O6/c1-17(2)5-6-20-24(3,33-20)22-21(29-4)19(7-8-25(22)16-31-25)32-23(28)27-14-18(15-27)13-26-9-11-30-12-10-26/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152763
PNG
(US9682965, 127)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CCC(C)C)OC(=O)N1CC(CCN2CCOCC2)C1
Show InChI InChI=1S/C26H44N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h18-23H,5-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM152675
PNG
(US9682965, 90)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCC2CCN(C)CC2)C1
Show InChI InChI=1S/C28H46N2O5/c1-19(2)6-9-23-27(3,35-23)25-24(32-5)22(10-13-28(25)18-33-28)34-26(31)30-16-21(17-30)8-7-20-11-14-29(4)15-12-20/h6,20-25H,7-18H2,1-5H3/t22-,23-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148462
PNG
(US9682965, 19)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC(C2)C(=O)N(C)C)C1
Show InChI InChI=1S/C28H45N3O6/c1-18(2)7-8-22-27(3,37-22)24-23(34-6)21(9-11-28(24)17-35-28)36-26(33)31-13-19(14-31)10-12-30-15-20(16-30)25(32)29(4)5/h7,19-24H,8-17H2,1-6H3/t21-,22-,23-,24-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM148475
PNG
(US9682965, 33)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC3CCC(C2)O3)C1
Show InChI InChI=1S/C28H44N2O6/c1-18(2)5-8-23-27(3,36-23)25-24(32-4)22(9-11-28(25)17-33-28)35-26(31)30-13-19(14-30)10-12-29-15-20-6-7-21(16-29)34-20/h5,19-25H,6-17H2,1-4H3/t20?,21?,22-,23-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%