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Patent code US9682969

Compile Data Set for Download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CFTR F508del


(Homo sapiens)
BDBM160521
PNG
(US9682969, 13)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(O)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19FN4O4/c1-14-27-21-9-6-17(11-22(21)34-14)29(2)23(32)13-30-25(33)20-12-18(31)7-8-19(20)24(28-30)15-4-3-5-16(26)10-15/h3-12,31H,13H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160528
PNG
(US9682969, 20 | US9682969, 25)
Show SMILES CC(C)Oc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C28H25ClN4O4/c1-16(2)36-21-9-10-22-23(14-21)28(35)33(31-27(22)18-6-5-7-19(29)12-18)15-26(34)32(4)20-8-11-24-25(13-20)37-17(3)30-24/h5-14,16H,15H2,1-4H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160511
PNG
(US9682969, 3)
Show SMILES COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C26H21FN4O4/c1-15-28-22-10-7-18(12-23(22)35-15)30(2)24(32)14-31-26(33)21-13-19(34-3)8-9-20(21)25(29-31)16-5-4-6-17(27)11-16/h4-13H,14H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160531
PNG
(US9682969, 23 | US9682969, 24)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OCC3CC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C29H25ClN4O4/c1-17-31-25-11-8-21(13-26(25)38-17)33(2)27(35)15-34-29(36)24-14-22(37-16-18-6-7-18)9-10-23(24)28(32-34)19-4-3-5-20(30)12-19/h3-5,8-14,18H,6-7,15-16H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160510
PNG
(US9682969, 2)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19FN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160515
PNG
(US9682969, 7 | US9682969, 9)
Show SMILES CCN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C27H23ClN4O4/c1-4-31(19-8-11-23-24(13-19)36-16(2)29-23)25(33)15-32-27(34)22-14-20(35-3)9-10-21(22)26(30-32)17-6-5-7-18(28)12-17/h5-14H,4,15H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160518
PNG
(US9682969, 10)
Show SMILES COc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(F)c1
Show InChI InChI=1S/C26H20ClFN4O4/c1-14-29-21-8-7-17(10-23(21)36-14)31(2)24(33)13-32-26(34)19-12-22(35-3)20(27)11-18(19)25(30-32)15-5-4-6-16(28)9-15/h4-12H,13H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160525
PNG
(US9682969, 17 | US9682969, 22)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C27H23FN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160534
PNG
(US9682969, 26)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC3CCCCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C31H29ClN4O4/c1-19-33-27-14-11-22(16-28(27)39-19)35(2)29(37)18-36-31(38)26-17-24(40-23-9-4-3-5-10-23)12-13-25(26)30(34-36)20-7-6-8-21(32)15-20/h6-8,11-17,23H,3-5,9-10,18H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160512
PNG
(US9682969, 4 | US9682969, 6)
Show SMILES COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H21ClN4O4/c1-15-28-22-10-7-18(12-23(22)35-15)30(2)24(32)14-31-26(33)21-13-19(34-3)8-9-20(21)25(29-31)16-5-4-6-17(27)11-16/h4-13H,14H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160516
PNG
(US9682969, 8)
Show SMILES CCN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(OC)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C27H23FN4O4/c1-4-31(19-8-11-23-24(13-19)36-16(2)29-23)25(33)15-32-27(34)22-14-20(35-3)9-10-21(22)26(30-32)17-6-5-7-18(28)12-17/h5-14H,4,15H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160520
PNG
(US9682969, 12)
Show SMILES COc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C28H23FN4O4/c1-16-30-24-11-8-20(13-25(24)37-16)33(19-6-7-19)26(34)15-32-28(35)23-14-21(36-2)9-10-22(23)27(31-32)17-4-3-5-18(29)12-17/h3-5,8-14,19H,6-7,15H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160536
PNG
(US9682969, 28)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(OC3CCCCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C31H29FN4O4/c1-19-33-27-14-11-22(16-28(27)39-19)35(2)29(37)18-36-31(38)26-17-24(40-23-9-4-3-5-10-23)12-13-25(26)30(34-36)20-7-6-8-21(32)15-20/h6-8,11-17,23H,3-5,9-10,18H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160546
PNG
(US9682969, 31)
Show SMILES CCOc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C27H22Cl2N4O4/c1-4-36-23-13-20-19(12-21(23)29)26(16-6-5-7-17(28)10-16)31-33(27(20)35)14-25(34)32(3)18-8-9-22-24(11-18)37-15(2)30-22/h5-13H,4,14H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160509
PNG
(US9682969, 1)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19ClN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160513
PNG
(US9682969, 5)
Show SMILES COc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C28H23ClN4O4/c1-16-30-24-11-8-20(13-25(24)37-16)33(19-6-7-19)26(34)15-32-28(35)23-14-21(36-2)9-10-22(23)27(31-32)17-4-3-5-18(29)12-17/h3-5,8-14,19H,6-7,15H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160524
PNG
(US9682969, 16)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19ClN4O4/c1-14-27-21-9-6-17(11-22(21)34-14)29(2)23(32)13-30-25(33)20-12-18(31)7-8-19(20)24(28-30)15-4-3-5-16(26)10-15/h3-12,31H,13H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160528
PNG
(US9682969, 20 | US9682969, 25)
Show SMILES CC(C)Oc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C28H25ClN4O4/c1-16(2)36-21-9-10-22-23(14-21)28(35)33(31-27(22)18-6-5-7-19(29)12-18)15-26(34)32(4)20-8-11-24-25(13-20)37-17(3)30-24/h5-14,16H,15H2,1-4H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160537
PNG
(US9682969, 29)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC3CCOCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C30H27ClN4O5/c1-18-32-26-9-6-21(15-27(26)39-18)34(2)28(36)17-35-30(37)25-16-23(40-22-10-12-38-13-11-22)7-8-24(25)29(33-35)19-4-3-5-20(31)14-19/h3-9,14-16,22H,10-13,17H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160512
PNG
(US9682969, 4 | US9682969, 6)
Show SMILES COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H21ClN4O4/c1-15-28-22-10-7-18(12-23(22)35-15)30(2)24(32)14-31-26(33)21-13-19(34-3)8-9-20(21)25(29-31)16-5-4-6-17(27)11-16/h4-13H,14H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160515
PNG
(US9682969, 7 | US9682969, 9)
Show SMILES CCN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C27H23ClN4O4/c1-4-31(19-8-11-23-24(13-19)36-16(2)29-23)25(33)15-32-27(34)22-14-20(35-3)9-10-21(22)26(30-32)17-6-5-7-18(28)12-17/h5-14H,4,15H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160523
PNG
(US9682969, 15)
Show SMILES Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O
Show InChI InChI=1S/C27H21ClN4O4/c1-15-29-23-10-7-19(12-24(23)36-15)32(18-5-6-18)25(34)14-31-27(35)22-13-20(33)8-9-21(22)26(30-31)16-3-2-4-17(28)11-16/h2-4,7-13,18,33H,5-6,14H2,1H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160527
PNG
(US9682969, 19)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C27H23ClN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
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Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160531
PNG
(US9682969, 23 | US9682969, 24)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OCC3CC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C29H25ClN4O4/c1-17-31-25-11-8-21(13-26(25)38-17)33(2)27(35)15-34-29(36)24-14-22(37-16-18-6-7-18)9-10-23(24)28(32-34)19-4-3-5-20(30)12-19/h3-5,8-14,18H,6-7,15-16H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160535
PNG
(US9682969, 27)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(OC3CCOCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C30H27FN4O5/c1-18-32-26-9-6-21(15-27(26)39-18)34(2)28(36)17-35-30(37)25-16-23(40-22-10-12-38-13-11-22)7-8-24(25)29(33-35)19-4-3-5-20(31)14-19/h3-9,14-16,22H,10-13,17H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160545
PNG
(US9682969, 30)
Show SMILES CCOc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(F)c1
Show InChI InChI=1S/C27H22ClFN4O4/c1-4-36-23-13-20-19(12-21(23)28)26(16-6-5-7-17(29)10-16)31-33(27(20)35)14-25(34)32(3)18-8-9-22-24(11-18)37-15(2)30-22/h5-13H,4,14H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160525
PNG
(US9682969, 17 | US9682969, 22)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C27H23FN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160526
PNG
(US9682969, 18)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C29H25ClN4O4/c1-3-37-22-10-11-23-24(15-22)29(36)33(32-28(23)18-5-4-6-19(30)13-18)16-27(35)34(20-7-8-20)21-9-12-25-26(14-21)38-17(2)31-25/h4-6,9-15,20H,3,7-8,16H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160529
PNG
(US9682969, 21)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C29H25FN4O4/c1-3-37-22-10-11-23-24(15-22)29(36)33(32-28(23)18-5-4-6-19(30)13-18)16-27(35)34(20-7-8-20)21-9-12-25-26(14-21)38-17(2)31-25/h4-6,9-15,20H,3,7-8,16H2,1-2H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160519
PNG
(US9682969, 11)
Show SMILES COc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H20Cl2N4O4/c1-14-29-21-8-7-17(10-23(21)36-14)31(2)24(33)13-32-26(34)19-12-22(35-3)20(28)11-18(19)25(30-32)15-5-4-6-16(27)9-15/h4-12H,13H2,1-3H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
CFTR F508del


(Homo sapiens)
BDBM160522
PNG
(US9682969, 14)
Show SMILES Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(O)cc2c1=O
Show InChI InChI=1S/C27H21FN4O4/c1-15-29-23-10-7-19(12-24(23)36-15)32(18-5-6-18)25(34)14-31-27(35)22-13-20(33)8-9-21(22)26(30-31)16-3-2-4-17(28)11-16/h2-4,7-13,18,33H,5-6,14H2,1H3
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Flatley Discovery Lab, LLC

US Patent


Assay Description
This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%