BindingDB logo
myBDB logout

Patent code US9682976

Compile Data Set for Download or QSAR

Found 324 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160840
PNG
(US9682976, 11)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161070
PNG
(US9682976, 24)
Show SMILES Fc1cnc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)nc1NC1CCN2CCCC2C1
Show InChI InChI=1S/C22H25F2N9/c23-17-9-16(13-3-4-13)20(33-12-26-30-31-33)10-19(17)28-22-25-11-18(24)21(29-22)27-14-5-7-32-6-1-2-15(32)8-14/h9-15H,1-8H2,(H2,25,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161073
PNG
(US9682976, 27 | US9682976, 29)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CCN5CCCC5C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C23H27F2N9O/c1-32-23(35)34(31-30-32)20-11-19(17(24)10-16(20)13-4-5-13)28-22-26-12-18(25)21(29-22)27-14-6-8-33-7-2-3-15(33)9-14/h10-15H,2-9H2,1H3,(H2,26,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161079
PNG
(US9682976, 33)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161159
PNG
(US9682976, 45)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CC(F)(F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H29F4N9O/c1-24(2)9-14(6-15-10-25(28,29)12-37(15)24)31-21-18(27)11-30-22(33-21)32-19-8-20(38-23(39)36(3)34-35-38)16(7-17(19)26)13-4-5-13/h7-8,11,13-15H,4-6,9-10,12H2,1-3H3,(H2,30,31,32,33)/t14-,15-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161162
PNG
(US9682976, 48)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@@H]2CCOC2)c1=O
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161165
PNG
(US9682976, 51)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2OC2CCOCC2)c1=O
Show InChI InChI=1S/C27H36FN9O3/c1-27(2)15-18(13-19-5-4-10-36(19)27)30-24-21(28)16-29-25(32-24)31-17-6-7-23(40-20-8-11-39-12-9-20)22(14-17)37-26(38)35(3)33-34-37/h6-7,14,16,18-20H,4-5,8-13,15H2,1-3H3,(H2,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161210
PNG
(US9682976, 69)
Show SMILES CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2nnn(C)c2=O)ncc1F
Show InChI InChI=1S/C26H33F2N9O/c1-14-20(12-26(2,3)36-9-5-6-21(14)36)30-23-18(28)13-29-24(32-23)31-19-11-22(37-25(38)35(4)33-34-37)16(10-17(19)27)15-7-8-15/h10-11,13-15,20-21H,5-9,12H2,1-4H3,(H2,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161391
PNG
(US9682976, 73)
Show SMILES CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(N(C)C(C)=O)c(cc2F)C2CC2)ncc1F
Show InChI InChI=1S/C27H36F2N6O/c1-15-22(13-27(3,4)35-10-6-7-23(15)35)31-25-20(29)14-30-26(33-25)32-21-12-24(34(5)16(2)36)18(11-19(21)28)17-8-9-17/h11-12,14-15,17,22-23H,6-10,13H2,1-5H3,(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161413
PNG
(US9682976, 80)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O
Show InChI InChI=1S/C27H35FN10O3/c1-26(2)12-17(9-18-7-6-8-37(18)26)31-23-16(13-29)14-30-24(33-23)32-20-11-21(38-25(39)36(5)34-35-38)22(10-19(20)28)41-15-27(3,4)40/h10-11,14,17-18,40H,6-9,12,15H2,1-5H3,(H2,30,31,32,33)/t17-,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161423
PNG
(US9682976, 87)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O
Show InChI InChI=1S/C26H35F2N9O3/c1-25(2)12-15(9-16-7-6-8-36(16)25)30-22-18(28)13-29-23(32-22)31-19-11-20(37-24(38)35(5)33-34-37)21(10-17(19)27)40-14-26(3,4)39/h10-11,13,15-16,39H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161454
PNG
(US9682976, 95)
Show SMILES CCc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O
Show InChI InChI=1S/C24H31F2N9O/c1-5-14-9-17(25)19(11-20(14)35-23(36)33(4)31-32-35)29-22-27-13-18(26)21(30-22)28-15-10-16-7-6-8-34(16)24(2,3)12-15/h9,11,13,15-16H,5-8,10,12H2,1-4H3,(H2,27,28,29,30)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161539
PNG
(US9682976, 103)
Show SMILES CC1(C)CC(C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCN(CC3)S(C)(=O)=O)c(c2)C#N)ncc1F
Show InChI InChI=1S/C26H35FN8O2S/c1-26(2)15-20(14-21-5-4-8-35(21)26)30-24-22(27)17-29-25(32-24)31-19-6-7-23(18(13-19)16-28)33-9-11-34(12-10-33)38(3,36)37/h6-7,13,17,20-21H,4-5,8-12,14-15H2,1-3H3,(H2,29,30,31,32)/t20?,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161540
PNG
(US9682976, 104)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3N(CC4CC4)C(=O)COc3c2)ncc1F
Show InChI InChI=1S/C26H33FN6O2/c1-26(2)12-18(10-19-4-3-9-33(19)26)29-24-20(27)13-28-25(31-24)30-17-7-8-21-22(11-17)35-15-23(34)32(21)14-16-5-6-16/h7-8,11,13,16,18-19H,3-6,9-10,12,14-15H2,1-2H3,(H2,28,29,30,31)/t18-,19+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161664
PNG
(US9682976, 123)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCNC[C@@H]3F)c(Cl)c2)ncc1F
Show InChI InChI=1S/C25H33ClF2N6O/c1-25(2)12-16(10-17-4-3-9-34(17)25)31-23-20(28)14-30-24(33-23)32-15-5-6-21(18(26)11-15)35-22-7-8-29-13-19(22)27/h5-6,11,14,16-17,19,22,29H,3-4,7-10,12-13H2,1-2H3,(H2,30,31,32,33)/t16-,17+,19+,22+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161679
PNG
(US9682976, 138)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N
Show InChI InChI=1S/C28H39FN8/c1-19(2)35-10-12-36(13-11-35)25-8-7-21(14-20(25)17-30)33-27-31-18-24(29)26(34-27)32-22-15-23-6-5-9-37(23)28(3,4)16-22/h7-8,14,18-19,22-23H,5-6,9-13,15-16H2,1-4H3,(H2,31,32,33,34)/t22-,23+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161699
PNG
(US9682976, 150)
Show SMILES Cc1nnnn1-c1ccc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1
Show InChI InChI=1S/C22H27ClFN9/c1-13-29-30-31-33(13)16-6-7-18(24)19(10-16)27-21-25-12-17(23)20(28-21)26-14-9-15-5-4-8-32(15)22(2,3)11-14/h6-7,10,12,14-15H,4-5,8-9,11H2,1-3H3,(H2,25,26,27,28)/t14-,15+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161716
PNG
(US9682976, 164)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)-n2nnnc2C2CC2)ncc1Cl
Show InChI InChI=1S/C24H29ClFN9/c1-24(2)12-15(10-16-4-3-9-34(16)24)28-21-18(25)13-27-23(30-21)29-20-11-17(7-8-19(20)26)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-16H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161726
PNG
(US9682976, 173)
Show SMILES CC1(COc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2C#N)COC1
Show InChI InChI=1S/C26H33FN6O2/c1-25(2)11-19(10-20-5-4-8-33(20)25)30-23-21(27)13-29-24(32-23)31-18-6-7-22(17(9-18)12-28)35-16-26(3)14-34-15-26/h6-7,9,13,19-20H,4-5,8,10-11,14-16H2,1-3H3,(H2,29,30,31,32)/t19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161749
PNG
(US9682976, 191)
Show SMILES CC(=O)O[C@@H]1COC(Oc2cc(F)c(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnn(C)c2=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
Show InChI InChI=1S/C33H41F2N9O9/c1-16(45)50-26-15-49-30(28(52-18(3)47)27(26)51-17(2)46)53-25-11-21(34)23(12-24(25)44-32(48)42(6)40-41-44)38-31-36-14-22(35)29(39-31)37-19-10-20-8-7-9-43(20)33(4,5)13-19/h11-12,14,19-20,26-28,30H,7-10,13,15H2,1-6H3,(H2,36,37,38,39)/t19-,20+,26-,27-,28+,30?/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161768
PNG
(US9682976, 206)
Show SMILES CC(O)COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1
Show InChI InChI=1S/C24H32FN9O2/c1-15(35)13-36-21-7-6-16(10-20(21)34-14-27-31-32-34)29-23-26-12-19(25)22(30-23)28-17-9-18-5-4-8-33(18)24(2,3)11-17/h6-7,10,12,14-15,17-18,35H,4-5,8-9,11,13H2,1-3H3,(H2,26,28,29,30)/t15?,17-,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161769
PNG
(US9682976, 207)
Show SMILES COCCOCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1
Show InChI InChI=1S/C26H36FN9O3/c1-26(2)15-19(13-20-5-4-8-35(20)26)30-24-21(27)16-28-25(32-24)31-18-6-7-23(39-12-11-38-10-9-37-3)22(14-18)36-17-29-33-34-36/h6-7,14,16-17,19-20H,4-5,8-13,15H2,1-3H3,(H2,28,30,31,32)/t19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161771
PNG
(US9682976, 209)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC(O)(C(F)(F)F)C(F)(F)F)c(c2)C#N)ncc1F
Show InChI InChI=1S/C25H27F7N6O2/c1-22(2)10-16(9-17-4-3-7-38(17)22)35-20-18(26)12-34-21(37-20)36-15-5-6-19(14(8-15)11-33)40-13-23(39,24(27,28)29)25(30,31)32/h5-6,8,12,16-17,39H,3-4,7,9-10,13H2,1-2H3,(H2,34,35,36,37)/t16-,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161785
PNG
(US9682976, 223)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2cnnn2)ncc1Cl
Show InChI InChI=1S/C23H30ClN9O2/c1-23(2)12-16(10-17-4-3-7-32(17)23)27-21-18(24)13-25-22(29-21)28-15-5-6-20(35-9-8-34)19(11-15)33-14-26-30-31-33/h5-6,11,13-14,16-17,34H,3-4,7-10,12H2,1-2H3,(H2,25,27,28,29)/t16-,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161800
PNG
(US9682976, 238)
Show SMILES CO[C@@H](C)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O
Show InChI InChI=1S/C26H35ClFN9O3/c1-15(39-5)14-40-22-10-19(28)20(11-21(22)37-25(38)35(4)33-34-37)31-24-29-13-18(27)23(32-24)30-16-9-17-7-6-8-36(17)26(2,3)12-16/h10-11,13,15-17H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+,17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161805
PNG
(US9682976, 242)
Show SMILES COc1cc(cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1F)-n1nnnc1C
Show InChI InChI=1S/C23H29F2N9O/c1-13-30-31-32-34(13)16-9-18(20(25)19(10-16)35-4)28-22-26-12-17(24)21(29-22)27-14-8-15-6-5-7-33(15)23(2,3)11-14/h9-10,12,14-15H,5-8,11H2,1-4H3,(H2,26,27,28,29)/t14-,15+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161809
PNG
(US9682976, 250)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nn(C(CO)CCl)c(=O)n4-c3c2)ncc1F
Show InChI InChI=1S/C28H36ClFN8O3/c1-27(2)12-17(10-18-6-5-9-36(18)27)32-23-20(30)14-31-25(34-23)33-16-7-8-22-21(11-16)37-24(28(3,4)41-22)35-38(26(37)40)19(13-29)15-39/h7-8,11,14,17-19,39H,5-6,9-10,12-13,15H2,1-4H3,(H2,31,32,33,34)/t17-,18+,19?/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161818
PNG
(US9682976, 255)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(OC3COC3)cc2F)-n2nnnc2C2CC2)ncc1F
Show InChI InChI=1S/C27H33F2N9O2/c1-27(2)11-16(8-17-4-3-7-37(17)27)31-24-20(29)12-30-26(33-24)32-21-10-22(38-25(15-5-6-15)34-35-36-38)23(9-19(21)28)40-18-13-39-14-18/h9-10,12,15-18H,3-8,11,13-14H2,1-2H3,(H2,30,31,32,33)/t16-,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161831
PNG
(US9682976, 268)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nn(CCO)c(=O)n4-c3c2)ncc1F
Show InChI InChI=1S/C27H35FN8O3/c1-26(2)14-17(12-18-6-5-9-34(18)26)30-22-19(28)15-29-24(32-22)31-16-7-8-21-20(13-16)36-23(27(3,4)39-21)33-35(10-11-37)25(36)38/h7-8,13,15,17-18,37H,5-6,9-12,14H2,1-4H3,(H2,29,30,31,32)/t17-,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161833
PNG
(US9682976, 270)
Show SMILES CS(=O)c1nnnn1-c1cccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1
Show InChI InChI=1S/C22H28FN9OS/c1-22(2)12-15(11-16-8-5-9-31(16)22)25-19-18(23)13-24-20(27-19)26-14-6-4-7-17(10-14)32-21(34(3)33)28-29-30-32/h4,6-7,10,13,15-16H,5,8-9,11-12H2,1-3H3,(H2,24,25,26,27)/t15-,16+,34?/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161829
PNG
(US9682976, 266 | US9682976, 271)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SCCO)ncc1F
Show InChI InChI=1S/C23H30FN9OS/c1-23(2)13-16(12-17-7-4-8-32(17)23)26-20-19(24)14-25-21(28-20)27-15-5-3-6-18(11-15)33-22(29-30-31-33)35-10-9-34/h3,5-6,11,14,16-17,34H,4,7-10,12-13H2,1-2H3,(H2,25,26,27,28)/t16-,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161835
PNG
(US9682976, 272)
Show SMILES Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nn[nH]c1=O
Show InChI InChI=1S/C22H28FN9O/c1-13-6-7-14(10-18(13)32-21(33)28-29-30-32)26-20-24-12-17(23)19(27-20)25-15-9-16-5-4-8-31(16)22(2,3)11-15/h6-7,10,12,15-16H,4-5,8-9,11H2,1-3H3,(H,28,30,33)(H2,24,25,26,27)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161866
PNG
(US9682976, 296)
Show SMILES COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2c1nn(C)c2=O
Show InChI InChI=1S/C28H37FN8O4/c1-27(2)13-18(11-19-7-6-10-36(19)27)31-23-20(29)14-30-25(33-23)32-17-8-9-22-21(12-17)37-24(34-35(3)26(37)38)28(41-22,15-39-4)16-40-5/h8-9,12,14,18-19H,6-7,10-11,13,15-16H2,1-5H3,(H2,30,31,32,33)/t18-,19+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161890
PNG
(US9682976, 309)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5[C@@H](CCC5(C)C)C4)n3)c(F)cc2OC2CC(O)C2)c1=O
Show InChI InChI=1S/C26H33F2N9O3/c1-26(2)6-4-15-8-14(5-7-36(15)26)30-23-19(28)13-29-24(32-23)31-20-12-21(37-25(39)35(3)33-34-37)22(11-18(20)27)40-17-9-16(38)10-17/h11-17,38H,4-10H2,1-3H3,(H2,29,30,31,32)/t14-,15-,16?,17?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160835
PNG
(US9682976, 6)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(NC3CC4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160836
PNG
(US9682976, 7)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161172
PNG
(US9682976, 58)
Show SMILES CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCOC3)c(c2)C#N)ncc1F
Show InChI InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161174
PNG
(US9682976, 60)
Show SMILES CC1(C)C[C@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCOC3)c(c2)C#N)ncc1F
Show InChI InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161181
PNG
(US9682976, 67)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5C[C@H](F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H30F3N9O/c1-25(2)10-15(7-16-6-14(26)12-36(16)25)30-22-19(28)11-29-23(32-22)31-20-9-21(37-24(38)35(3)33-34-37)17(8-18(20)27)13-4-5-13/h8-9,11,13-16H,4-7,10,12H2,1-3H3,(H2,29,30,31,32)/t14-,15+,16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161394
PNG
(US9682976, 75)
Show SMILES CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(OC(F)F)c(cc2F)C2CC2)ncc1F
Show InChI InChI=1S/C25H31F4N5O/c1-13-19(11-25(2,3)34-8-4-5-20(13)34)31-22-17(27)12-30-24(33-22)32-18-10-21(35-23(28)29)15(9-16(18)26)14-6-7-14/h9-10,12-14,19-20,23H,4-8,11H2,1-3H3,(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161420
PNG
(US9682976, 84)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC(C)(C)CO)c1=O
Show InChI InChI=1S/C27H35FN10O3/c1-26(2)12-17(9-18-7-6-8-37(18)26)31-23-16(13-29)14-30-24(33-23)32-20-11-21(38-25(40)36(5)34-35-38)22(10-19(20)28)41-27(3,4)15-39/h10-11,14,17-18,39H,6-9,12,15H2,1-5H3,(H2,30,31,32,33)/t17-,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161432
PNG
(US9682976, 92)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C=C)c1=O
Show InChI InChI=1S/C24H29F2N9O/c1-5-14-9-17(25)19(11-20(14)35-23(36)33(4)31-32-35)29-22-27-13-18(26)21(30-22)28-15-10-16-7-6-8-34(16)24(2,3)12-15/h5,9,11,13,15-16H,1,6-8,10,12H2,2-4H3,(H2,27,28,29,30)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161643
PNG
(US9682976, 107)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCC(O)CC3)c(c2)C#N)ncc1F
Show InChI InChI=1S/C26H34FN7O/c1-26(2)14-19(13-20-4-3-9-34(20)26)30-24-22(27)16-29-25(32-24)31-18-5-6-23(17(12-18)15-28)33-10-7-21(35)8-11-33/h5-6,12,16,19-21,35H,3-4,7-11,13-14H2,1-2H3,(H2,29,30,31,32)/t19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161659
PNG
(US9682976, 118)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCNCC3)c(c2)C(F)(F)F)ncc1F
Show InChI InChI=1S/C26H34F4N6O/c1-25(2)14-17(12-18-4-3-11-36(18)25)33-23-21(27)15-32-24(35-23)34-16-5-6-22(20(13-16)26(28,29)30)37-19-7-9-31-10-8-19/h5-6,13,15,17-19,31H,3-4,7-12,14H2,1-2H3,(H2,32,33,34,35)/t17-,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161661
PNG
(US9682976, 120)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCN(CC3)C3COC3)c(c2)C(F)(F)F)ncc1F
Show InChI InChI=1S/C29H38F4N6O2/c1-28(2)14-19(12-20-4-3-9-39(20)28)35-26-24(30)15-34-27(37-26)36-18-5-6-25(23(13-18)29(31,32)33)41-22-7-10-38(11-8-22)21-16-40-17-21/h5-6,13,15,19-22H,3-4,7-12,14,16-17H2,1-2H3,(H2,34,35,36,37)/t19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161670
PNG
(US9682976, 129)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2nnnc2C2CC2)ncc1F
Show InChI InChI=1S/C26H34FN9O2/c1-26(2)14-18(12-19-4-3-9-35(19)26)29-23-20(27)15-28-25(31-23)30-17-7-8-22(38-11-10-37)21(13-17)36-24(16-5-6-16)32-33-34-36/h7-8,13,15-16,18-19,37H,3-6,9-12,14H2,1-2H3,(H2,28,29,30,31)/t18-,19+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161671
PNG
(US9682976, 130)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(F)c2)ncc1F
Show InChI InChI=1S/C22H29F2N5O2/c1-22(2)12-15(10-16-4-3-7-29(16)22)26-20-18(24)13-25-21(28-20)27-14-5-6-19(17(23)11-14)31-9-8-30/h5-6,11,13,15-16,30H,3-4,7-10,12H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161676
PNG
(US9682976, 135)
Show SMILES C[C@@H](CO)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O
Show InChI InChI=1S/C25H34FN9O3/c1-15(14-36)38-21-8-7-16(11-20(21)35-24(37)33(4)31-32-35)29-23-27-13-19(26)22(30-23)28-17-10-18-6-5-9-34(18)25(2,3)12-17/h7-8,11,13,15,17-18,36H,5-6,9-10,12,14H2,1-4H3,(H2,27,28,29,30)/t15-,17+,18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161690
PNG
(US9682976, 144)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)-n2nnnc2C2CC2)ncc1F
Show InChI InChI=1S/C24H29F2N9/c1-24(2)12-15(10-16-4-3-9-34(16)24)28-21-19(26)13-27-23(30-21)29-20-11-17(7-8-18(20)25)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-16H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161713
PNG
(US9682976, 161)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(OC)c1
Show InChI InChI=1S/C22H30FN5O2/c1-22(2)12-15(8-16-6-5-7-28(16)22)25-20-19(23)13-24-21(27-20)26-14-9-17(29-3)11-18(10-14)30-4/h9-11,13,15-16H,5-8,12H2,1-4H3,(H2,24,25,26,27)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 324 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%