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Patent code US9682991

Compile Data Set for Download or QSAR
Found 198 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161942
PNG
(US9682991, 5)
Show SMILES CN(C)C1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-29(2)15-7-9-31(10-8-15)20-17-18(33-12-11-30(17)3)21-27-26-19(32(21)28-20)14-5-4-6-16(13-14)34-22(23,24)25/h4-6,13,15H,7-12H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161946
PNG
(US9682991, 7)
Show SMILES CN1CCOc2c1c(NCC1CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N6O2/c1-27-7-8-29-15-14(27)16(23-10-11-5-6-11)26-28-17(24-25-18(15)28)12-3-2-4-13(9-12)30-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,23,26)
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n/an/a 25n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161950
PNG
(US9682991, 9)
Show SMILES CN1CCOc2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H18F4N6O2/c1-31-9-10-33-18-17(31)19(27-12-13-5-7-15(23)8-6-13)30-32-20(28-29-21(18)32)14-3-2-4-16(11-14)34-22(24,25)26/h2-8,11H,9-10,12H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162031
PNG
(US9682991, 87)
Show SMILES CC(C)NC1CC2(C1)CCN(CC2)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H32F3N7O2/c1-16(2)30-18-14-25(15-18)7-9-35(10-8-25)23-20-21(37-12-11-34(20)3)24-32-31-22(36(24)33-23)17-5-4-6-19(13-17)38-26(27,28)29/h4-6,13,16,18,30H,7-12,14-15H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162048
PNG
(US9682991, 102)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(NCC3CC3)nn12
Show InChI InChI=1S/C18H16F3N5O3/c19-18(20,21)29-12-3-1-2-11(8-12)16-23-24-17-14-13(27-6-7-28-14)15(25-26(16)17)22-9-10-4-5-10/h1-3,8,10H,4-7,9H2,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161938
PNG
(US9682991, 2)
Show SMILES CN1CCC(CC1)Nc1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-8-6-14(7-9-29)25-18-16-17(32-11-10-30(16)2)20-27-26-19(31(20)28-18)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161978
PNG
(US9682991, 27)
Show SMILES CN1CCN(CCNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H27F3N8O2/c1-30-8-10-32(11-9-30)7-6-26-19-17-18(34-13-12-31(17)2)21-28-27-20(33(21)29-19)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161994
PNG
(US9682991, 43)
Show SMILES CN1CCOc2c1c(NCC1CC[C@H](O)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H25F3N6O3/c1-30-9-10-33-18-17(30)19(26-12-13-5-7-15(32)8-6-13)29-31-20(27-28-21(18)31)14-3-2-4-16(11-14)34-22(23,24)25/h2-4,11,13,15,32H,5-10,12H2,1H3,(H,26,29)/t13?,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161998
PNG
(US9682991, 50)
Show SMILES CC1COc2c(N1C)c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1S/C24H28F3N7O2/c1-14-13-35-19-18(32(14)2)21(33-8-6-23(7-9-33)11-16(28)12-23)31-34-20(29-30-22(19)34)15-4-3-5-17(10-15)36-24(25,26)27/h3-5,10,14,16H,6-9,11-13,28H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162055
PNG
(US9682991, 56)
Show SMILES CN1CCOc2c1c(NCC1CCNCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-12-13-5-7-25-8-6-13)29-31-19(27-28-20(17)31)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13,25H,5-10,12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162012
PNG
(US9682991, 68)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCCC2(CCNCC2)C1
Show InChI InChI=1S/C24H28F3N7O2/c1-32-12-13-35-19-18(32)21(33-11-3-6-23(15-33)7-9-28-10-8-23)31-34-20(29-30-22(19)34)16-4-2-5-17(14-16)36-24(25,26)27/h2,4-5,14,28H,3,6-13,15H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162014
PNG
(US9682991, 70)
Show SMILES CN1CCOc2c1c(N[C@@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-14-7-5-13(25)6-8-14)29-31-19(27-28-20(17)31)12-3-2-4-15(11-12)33-21(22,23)24/h2-4,11,13-14H,5-10,25H2,1H3,(H,26,29)/t13-,14+
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162017
PNG
(US9682991, 73)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCC(C)(C)N(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C24H30F3N7O2/c1-23(2)14-35-19-18(33(23)4)20(28-13-15-8-10-32(3)11-9-15)31-34-21(29-30-22(19)34)16-6-5-7-17(12-16)36-24(25,26)27/h5-7,12,15H,8-11,13-14H2,1-4H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161968
PNG
(US9682991, 17)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3N(C)CCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H26F3N7O2/c1-30-8-6-14(7-9-30)13-26-19-18-17(31(2)10-11-33-18)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161974
PNG
(US9682991, 23)
Show SMILES CN1CCOc2c1c(NC1CCOCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H21F3N6O3/c1-28-7-10-31-16-15(28)17(24-13-5-8-30-9-6-13)27-29-18(25-26-19(16)29)12-3-2-4-14(11-12)32-20(21,22)23/h2-4,11,13H,5-10H2,1H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162002
PNG
(US9682991, 55)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19(30-7-5-13(12-25)6-8-30)28-31-18(26-27-20(17)31)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162002
PNG
(US9682991, 55)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19(30-7-5-13(12-25)6-8-30)28-31-18(26-27-20(17)31)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162003
PNG
(US9682991, 57)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19-27-26-18(14-3-2-4-15(11-14)33-21(22,23)24)31(19)28-20(17)30-7-5-13(12-25)6-8-30/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162004
PNG
(US9682991, 59)
Show SMILES CN1CCOc2c1c(NCC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H28F3N7O2/c1-33-9-10-35-19-18(33)20(29-14-15-12-23(13-15)5-7-28-8-6-23)32-34-21(30-31-22(19)34)16-3-2-4-17(11-16)36-24(25,26)27/h2-4,11,15,28H,5-10,12-14H2,1H3,(H,29,32)
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162032
PNG
(US9682991, 88)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC3CC3)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)22(29-14-16-7-9-34(10-8-16)15-17-5-6-17)32-35-23(30-31-24(21)35)18-3-2-4-19(13-18)37-25(26,27)28/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162037
PNG
(US9682991, 93)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC1)C(C)=O)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O3/c1-14(34)32-8-6-15(7-9-32)13-27-20-18-19(35-11-10-31(18)2)22-29-28-21(33(22)30-20)16-4-3-5-17(12-16)36-23(24,25)26/h3-5,12,15H,6-11,13H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162049
PNG
(US9682991, 103)
Show InChI InChI=1S/C21H24F3N7O3/c1-29-8-11-33-17-16(29)18(25-14-6-9-31(2,32)10-7-14)28-30-19(26-27-20(17)30)13-4-3-5-15(12-13)34-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161956
PNG
(US9682991, 11)
Show SMILES CCN1CCOc2c1c(NCC1CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H21F3N6O2/c1-2-28-8-9-30-16-15(28)17(24-11-12-6-7-12)27-29-18(25-26-19(16)29)13-4-3-5-14(10-13)31-20(21,22)23/h3-5,10,12H,2,6-9,11H2,1H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161967
PNG
(US9682991, 16)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H26F3N7O2/c1-30-8-6-14(7-9-30)13-26-19-17-18(33-11-10-31(17)2)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161972
PNG
(US9682991, 21)
Show SMILES CN1CCOc2c1c(NCCCO)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N6O3/c1-26-7-9-29-14-13(26)15(22-6-3-8-28)25-27-16(23-24-17(14)27)11-4-2-5-12(10-11)30-18(19,20)21/h2,4-5,10,28H,3,6-9H2,1H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161983
PNG
(US9682991, 32)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N7O/c1-30-8-6-14(7-9-30)13-26-19-17-18(33-11-10-31(17)2)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161994
PNG
(US9682991, 43)
Show SMILES CN1CCOc2c1c(NCC1CC[C@H](O)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H25F3N6O3/c1-30-9-10-33-18-17(30)19(26-12-13-5-7-15(32)8-6-13)29-31-20(27-28-21(18)31)14-3-2-4-16(11-14)34-22(23,24)25/h2-4,11,13,15,32H,5-10,12H2,1H3,(H,26,29)/t13?,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162009
PNG
(US9682991, 65)
Show SMILES CN1CCOc2c(NC3CC4(C3)CCNCC4)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O2/c1-32-9-10-34-18-17(32)21-30-29-20(14-3-2-4-16(11-14)35-23(24,25)26)33(21)31-19(18)28-15-12-22(13-15)5-7-27-8-6-22/h2-4,11,15,27H,5-10,12-13H2,1H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162029
PNG
(US9682991, 85)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)22-19-20(35-12-11-32(19)3)23-30-29-21(34(23)31-22)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162044
PNG
(US9682991, 98)
Show SMILES CN(CCN1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O3/c1-29-8-13-34-18-17(29)20(30(2)6-7-31-9-11-33-12-10-31)28-32-19(26-27-21(18)32)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161946
PNG
(US9682991, 7)
Show SMILES CN1CCOc2c1c(NCC1CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N6O2/c1-27-7-8-29-15-14(27)16(23-10-11-5-6-11)26-28-17(24-25-18(15)28)12-3-2-4-13(9-12)30-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161957
PNG
(US9682991, 12)
Show SMILES CCN1CCOc2c1c(NCC1CCN(C)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-3-32-11-12-34-19-18(32)20(27-14-15-7-9-31(2)10-8-15)30-33-21(28-29-22(19)33)16-5-4-6-17(13-16)35-23(24,25)26/h4-6,13,15H,3,7-12,14H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161974
PNG
(US9682991, 23)
Show SMILES CN1CCOc2c1c(NC1CCOCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H21F3N6O3/c1-28-7-10-31-16-15(28)17(24-13-5-8-30-9-6-13)27-29-18(25-26-19(16)29)12-3-2-4-14(11-12)32-20(21,22)23/h2-4,11,13H,5-10H2,1H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162053
PNG
(US9682991, 49)
Show SMILES CN1CCOc2c1c(NC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O2/c1-32-9-10-34-18-17(32)19(28-15-12-22(13-15)5-7-27-8-6-22)31-33-20(29-30-21(18)33)14-3-2-4-16(11-14)35-23(24,25)26/h2-4,11,15,27H,5-10,12-13H2,1H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162056
PNG
(US9682991, 58)
Show SMILES CN1CCOc2c(NCC3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)20-28-27-19(14-3-2-4-15(11-14)33-21(22,23)24)31(20)29-18(17)26-12-13-5-7-25-8-6-13/h2-4,11,13,25H,5-10,12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162004
PNG
(US9682991, 59)
Show SMILES CN1CCOc2c1c(NCC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H28F3N7O2/c1-33-9-10-35-19-18(33)20(29-14-15-12-23(13-15)5-7-28-8-6-23)32-34-21(30-31-22(19)34)16-3-2-4-17(11-16)36-24(25,26)27/h2-4,11,15,28H,5-10,12-14H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162037
PNG
(US9682991, 93)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC1)C(C)=O)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O3/c1-14(34)32-8-6-15(7-9-32)13-27-20-18-19(35-11-10-31(18)2)22-29-28-21(33(22)30-20)16-4-3-5-17(12-16)36-23(24,25)26/h3-5,12,15H,6-11,13H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162038
PNG
(US9682991, 94)
Show SMILES CN1CCN(C)c2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1ccc(O)cc1
Show InChI InChI=1S/C22H22FN7O/c1-28-11-12-29(2)19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-30-21(25-26-22(19)30)15-5-9-17(31)10-6-15/h3-10,31H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162043
PNG
(US9682991, 97)
Show SMILES CN(C1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-28-8-11-32-17-16(28)19(29(2)14-6-9-31-10-7-14)27-30-18(25-26-20(17)30)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162048
PNG
(US9682991, 102)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(NCC3CC3)nn12
Show InChI InChI=1S/C18H16F3N5O3/c19-18(20,21)29-12-3-1-2-11(8-12)16-23-24-17-14-13(27-6-7-28-14)15(25-26(16)17)22-9-10-4-5-10/h1-3,8,10H,4-7,9H2,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161970
PNG
(US9682991, 19)
Show SMILES CN1CCOc2c1c(N[C@H]1CC[C@H](O)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-9-10-32-17-16(29)18(25-13-5-7-14(31)8-6-13)28-30-19(26-27-20(17)30)12-3-2-4-15(11-12)33-21(22,23)24/h2-4,11,13-14,31H,5-10H2,1H3,(H,25,28)/t13-,14-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161986
PNG
(US9682991, 35)
Show SMILES CN([C@H]1CC[C@H](O)CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H25F3N6O3/c1-29-10-11-33-18-17(29)20(30(2)14-6-8-15(32)9-7-14)28-31-19(26-27-21(18)31)13-4-3-5-16(12-13)34-22(23,24)25/h3-5,12,14-15,32H,6-11H2,1-2H3/t14-,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161992
PNG
(US9682991, 41)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-7-5-13(6-8-29)12-25-18-16-17(32-10-9-31-16)20-27-26-19(30(20)28-18)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162011
PNG
(US9682991, 67)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC2(CCCNC2)CC1
Show InChI InChI=1S/C24H28F3N7O2/c1-32-12-13-35-19-18(32)21(33-10-7-23(8-11-33)6-3-9-28-15-23)31-34-20(29-30-22(19)34)16-4-2-5-17(14-16)36-24(25,26)27/h2,4-5,14,28H,3,6-13,15H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162025
PNG
(US9682991, 81)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161983
PNG
(US9682991, 32)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N7O/c1-30-8-6-14(7-9-30)13-26-19-17-18(33-11-10-31(17)2)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161985
PNG
(US9682991, 34)
Show SMILES CN(C)c1cccc(c1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(C)CC3)nn12
Show InChI InChI=1S/C23H32N8O/c1-28(2)18-7-5-6-17(14-18)22-25-26-23-20-19(30(4)12-13-32-20)21(27-31(22)23)24-15-16-8-10-29(3)11-9-16/h5-7,14,16H,8-13,15H2,1-4H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161990
PNG
(US9682991, 39)
Show SMILES CC1COc2c(N1C)c(NCC1CCN(C)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-13-34-19-18(32(14)3)20(27-12-15-7-9-31(2)10-8-15)30-33-21(28-29-22(19)33)16-5-4-6-17(11-16)35-23(24,25)26/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161991
PNG
(US9682991, 40)
Show SMILES CC1CN(C)c2c(NCC3CCN(C)CC3)nn3c(nnc3c2O1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-13-32(3)18-19(34-14)22-29-28-21(16-5-4-6-17(11-16)35-23(24,25)26)33(22)30-20(18)27-12-15-7-9-31(2)10-8-15/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162006
PNG
(US9682991, 62)
Show SMILES CNC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-25-14-6-8-30(9-7-14)19-16-17(32-11-10-29(16)2)20-27-26-18(31(20)28-19)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162006
PNG
(US9682991, 62)
Show SMILES CNC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-25-14-6-8-30(9-7-14)19-16-17(32-11-10-29(16)2)20-27-26-18(31(20)28-19)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162007
PNG
(US9682991, 63)
Show SMILES CNCC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-26-13-14-6-8-31(9-7-14)20-17-18(33-11-10-30(17)2)21-28-27-19(32(21)29-20)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14,26H,6-11,13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162015
PNG
(US9682991, 71)
Show SMILES CN1CCOc2c1c(N[C@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-14-7-5-13(25)6-8-14)29-31-19(27-28-20(17)31)12-3-2-4-15(11-12)33-21(22,23)24/h2-4,11,13-14H,5-10,25H2,1H3,(H,26,29)/t13-,14-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161977
PNG
(US9682991, 26)
Show SMILES CN1CCOc2c1c(NCCc1cccnc1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O2/c1-31-10-11-33-18-17(31)19(27-9-7-14-4-3-8-26-13-14)30-32-20(28-29-21(18)32)15-5-2-6-16(12-15)34-22(23,24)25/h2-6,8,12-13H,7,9-11H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161980
PNG
(US9682991, 29)
Show SMILES CN1CCOc2c1c(NCCN1CCOCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O3/c1-29-7-12-33-17-16(29)18(25-5-6-30-8-10-32-11-9-30)28-31-19(26-27-20(17)31)14-3-2-4-15(13-14)34-21(22,23)24/h2-4,13H,5-12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161986
PNG
(US9682991, 35)
Show SMILES CN([C@H]1CC[C@H](O)CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H25F3N6O3/c1-29-10-11-33-18-17(29)20(30(2)14-6-8-15(32)9-7-14)28-31-19(26-27-21(18)31)13-4-3-5-16(12-13)34-22(23,24)25/h3-5,12,14-15,32H,6-11H2,1-2H3/t14-,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161991
PNG
(US9682991, 40)
Show SMILES CC1CN(C)c2c(NCC3CCN(C)CC3)nn3c(nnc3c2O1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-13-32(3)18-19(34-14)22-29-28-21(16-5-4-6-17(11-16)35-23(24,25)26)33(22)30-20(18)27-12-15-7-9-31(2)10-8-15/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161997
PNG
(US9682991, 48)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1S/C23H26F3N7O2/c1-31-9-10-34-18-17(31)20(32-7-5-22(6-8-32)12-15(27)13-22)30-33-19(28-29-21(18)33)14-3-2-4-16(11-14)35-23(24,25)26/h2-4,11,15H,5-10,12-13,27H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162001
PNG
(US9682991, 54)
Show SMILES CN1CCOc2c1c(NCC13CCN(CC1)C3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)18(26-12-21-5-7-31(13-21)8-6-21)29-32-19(27-28-20(17)32)14-3-2-4-15(11-14)34-22(23,24)25/h2-4,11H,5-10,12-13H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162005
PNG
(US9682991, 60)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCCC2(CCCN2)CC1
Show InChI InChI=1S/C24H28F3N7O2/c1-32-13-14-35-19-18(32)21(33-11-4-8-23(9-12-33)7-3-10-28-23)31-34-20(29-30-22(19)34)16-5-2-6-17(15-16)36-24(25,26)27/h2,5-6,15,28H,3-4,7-14H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162007
PNG
(US9682991, 63)
Show SMILES CNCC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-26-13-14-6-8-31(9-7-14)20-17-18(33-11-10-30(17)2)21-28-27-19(32(21)29-20)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14,26H,6-11,13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162043
PNG
(US9682991, 97)
Show SMILES CN(C1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-28-8-11-32-17-16(28)19(29(2)14-6-9-31-10-7-14)27-30-18(25-26-20(17)30)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162047
PNG
(US9682991, 101)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(nn12)N1CCCCC1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)30-13-6-4-5-12(11-13)16-23-24-17-14-15(29-10-9-28-14)18(25-27(16)17)26-7-2-1-3-8-26/h4-6,11H,1-3,7-10H2
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162057
PNG
(US9682991, 61)
Show SMILES CN1CCCC11CCCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-32-14-15-36-20-19(32)22(34-12-5-9-24(10-13-34)8-4-11-33(24)2)31-35-21(29-30-23(20)35)17-6-3-7-18(16-17)37-25(26,27)28/h3,6-7,16H,4-5,8-15H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162008
PNG
(US9682991, 64)
Show SMILES CN(CC1CCNCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-30-10-11-33-18-17(30)20(31(2)13-14-6-8-26-9-7-14)29-32-19(27-28-21(18)32)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14,26H,6-11,13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162010
PNG
(US9682991, 66)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1S/C23H26F3N7O2/c1-31-9-10-34-18-17(31)20-29-28-19(14-3-2-4-16(11-14)35-23(24,25)26)33(20)30-21(18)32-7-5-22(6-8-32)12-15(27)13-22/h2-4,11,15H,5-10,12-13,27H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162012
PNG
(US9682991, 68)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCCC2(CCNCC2)C1
Show InChI InChI=1S/C24H28F3N7O2/c1-32-12-13-35-19-18(32)21(33-11-3-6-23(15-33)7-9-28-10-8-23)31-34-20(29-30-22(19)34)16-4-2-5-17(14-16)36-24(25,26)27/h2,4-5,14,28H,3,6-13,15H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162013
PNG
(US9682991, 69)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CC2(C1)CCCNC2
Show InChI InChI=1S/C22H24F3N7O2/c1-30-8-9-33-17-16(30)19(31-12-21(13-31)6-3-7-26-11-21)29-32-18(27-28-20(17)32)14-4-2-5-15(10-14)34-22(23,24)25/h2,4-5,10,26H,3,6-9,11-13H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162046
PNG
(US9682991, 100)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H26FN7O/c1-27-9-7-14(8-10-27)13-23-19-17-18(30-12-11-28(17)2)21-25-24-20(29(21)26-19)15-3-5-16(22)6-4-15/h3-6,14H,7-13H2,1-2H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161982
PNG
(US9682991, 31)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C22H26N8O/c1-28-8-6-15(7-9-28)14-24-20-18-19(31-11-10-29(18)2)22-26-25-21(30(22)27-20)17-5-3-4-16(12-17)13-23/h3-5,12,15H,6-11,14H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162006
PNG
(US9682991, 62)
Show SMILES CNC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-25-14-6-8-30(9-7-14)19-16-17(32-11-10-29(16)2)20-27-26-18(31(20)28-19)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162013
PNG
(US9682991, 69)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CC2(C1)CCCNC2
Show InChI InChI=1S/C22H24F3N7O2/c1-30-8-9-33-17-16(30)19(31-12-21(13-31)6-3-7-26-11-21)29-32-18(27-28-20(17)32)14-4-2-5-15(10-14)34-22(23,24)25/h2,4-5,10,26H,3,6-9,11-13H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162017
PNG
(US9682991, 73)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCC(C)(C)N(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C24H30F3N7O2/c1-23(2)14-35-19-18(33(23)4)20(28-13-15-8-10-32(3)11-9-15)31-34-21(29-30-22(19)34)16-6-5-7-17(12-16)36-24(25,26)27/h5-7,12,15H,8-11,13-14H2,1-4H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162029
PNG
(US9682991, 85)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)22-19-20(35-12-11-32(19)3)23-30-29-21(34(23)31-22)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161947
PNG
(US9682991, 8)
Show SMILES CN1CCOc2c(NCC3CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N6O2/c1-27-7-8-29-15-14(27)18-25-24-17(28(18)26-16(15)23-10-11-5-6-11)12-3-2-4-13(9-12)30-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161974
PNG
(US9682991, 23)
Show SMILES CN1CCOc2c1c(NC1CCOCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H21F3N6O3/c1-28-7-10-31-16-15(28)17(24-13-5-8-30-9-6-13)27-29-18(25-26-19(16)29)12-3-2-4-14(11-12)32-20(21,22)23/h2-4,11,13H,5-10H2,1H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162050
PNG
(US9682991, 45)
Show SMILES CN(C1CCNCC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-10-11-32-17-16(29)19-27-26-18(13-4-3-5-15(12-13)33-21(22,23)24)31(19)28-20(17)30(2)14-6-8-25-9-7-14/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162009
PNG
(US9682991, 65)
Show SMILES CN1CCOc2c(NC3CC4(C3)CCNCC4)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O2/c1-32-9-10-34-18-17(32)21-30-29-20(14-3-2-4-16(11-14)35-23(24,25)26)33(21)31-19(18)28-15-12-22(13-15)5-7-27-8-6-22/h2-4,11,15,27H,5-10,12-13H2,1H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162010
PNG
(US9682991, 66)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1S/C23H26F3N7O2/c1-31-9-10-34-18-17(31)20-29-28-19(14-3-2-4-16(11-14)35-23(24,25)26)33(20)30-21(18)32-7-5-22(6-8-32)12-15(27)13-22/h2-4,11,15H,5-10,12-13,27H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162016
PNG
(US9682991, 72)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3N(C)C(C)(C)COc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C24H30F3N7O2/c1-23(2)14-35-19-18(33(23)4)22-30-29-21(16-6-5-7-17(12-16)36-24(25,26)27)34(22)31-20(19)28-13-15-8-10-32(3)11-9-15/h5-7,12,15H,8-11,13-14H2,1-4H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162029
PNG
(US9682991, 85)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)22-19-20(35-12-11-32(19)3)23-30-29-21(34(23)31-22)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162047
PNG
(US9682991, 101)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(nn12)N1CCCCC1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)30-13-6-4-5-12(11-13)16-23-24-17-14-15(29-10-9-28-14)18(25-27(16)17)26-7-2-1-3-8-26/h4-6,11H,1-3,7-10H2
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161942
PNG
(US9682991, 5)
Show SMILES CN(C)C1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-29(2)15-7-9-31(10-8-15)20-17-18(33-12-11-30(17)3)21-27-26-19(32(21)28-20)14-5-4-6-16(13-14)34-22(23,24)25/h4-6,13,15H,7-12H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161956
PNG
(US9682991, 11)
Show SMILES CCN1CCOc2c1c(NCC1CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H21F3N6O2/c1-2-28-8-9-30-16-15(28)17(24-11-12-6-7-12)27-29-18(25-26-19(16)29)13-4-3-5-14(10-13)31-20(21,22)23/h3-5,10,12H,2,6-9,11H2,1H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161972
PNG
(US9682991, 21)
Show SMILES CN1CCOc2c1c(NCCCO)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N6O3/c1-26-7-9-29-14-13(26)15(22-6-3-8-28)25-27-16(23-24-17(14)27)11-4-2-5-12(10-11)30-18(19,20)21/h2,4-5,10,28H,3,6-9H2,1H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161984
PNG
(US9682991, 33)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2ccc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C23H28N8O/c1-29-9-6-15(7-10-29)14-25-21-19-20(32-12-11-30(19)2)23-27-26-22(31(23)28-21)17-3-4-18-16(13-17)5-8-24-18/h3-5,8,13,15,24H,6-7,9-12,14H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161993
PNG
(US9682991, 42)
Show SMILES CN1CCOc2c(NCCN3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H25F3N8O2/c1-30-11-12-33-17-16(30)20-28-27-19(14-3-2-4-15(13-14)34-21(22,23)24)32(20)29-18(17)26-7-10-31-8-5-25-6-9-31/h2-4,13,25H,5-12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161996
PNG
(US9682991, 46)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C20H22F3N7O2/c1-28-9-10-31-16-15(28)18-26-25-17(12-3-2-4-14(11-12)32-20(21,22)23)30(18)27-19(16)29-7-5-13(24)6-8-29/h2-4,11,13H,5-10,24H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162054
PNG
(US9682991, 52)
Show SMILES COc1cccc(c1)-c1nnc2c3OCCN(C)c3c(NC3CCNCC3)nn12
Show InChI InChI=1S/C20H25N7O2/c1-26-10-11-29-17-16(26)18(22-14-6-8-21-9-7-14)25-27-19(23-24-20(17)27)13-4-3-5-15(12-13)28-2/h3-5,12,14,21H,6-11H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162005
PNG
(US9682991, 60)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCCC2(CCCN2)CC1
Show InChI InChI=1S/C24H28F3N7O2/c1-32-13-14-35-19-18(32)21(33-11-4-8-23(9-12-33)7-3-10-28-23)31-34-20(29-30-22(19)34)16-5-2-6-17(15-16)36-24(25,26)27/h2,5-6,15,28H,3-4,7-14H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162022
PNG
(US9682991, 79)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC1)C(=O)OC(C)(C)C)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H32F3N7O4/c1-25(2,3)40-24(37)35-10-8-16(9-11-35)15-30-21-19-20(38-13-12-34(19)4)23-32-31-22(36(23)33-21)17-6-5-7-18(14-17)39-26(27,28)29/h5-7,14,16H,8-13,15H2,1-4H3,(H,30,33)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162025
PNG
(US9682991, 81)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162033
PNG
(US9682991, 89)
Show SMILES CN1CCOc2c(NCC3CCN(CC4CC4)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)24-31-30-23(18-3-2-4-19(13-18)37-25(26,27)28)35(24)32-22(21)29-14-16-7-9-34(10-8-16)15-17-5-6-17/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162043
PNG
(US9682991, 97)
Show SMILES CN(C1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-28-8-11-32-17-16(28)19(29(2)14-6-9-31-10-7-14)27-30-18(25-26-20(17)30)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161968
PNG
(US9682991, 17)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3N(C)CCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H26F3N7O2/c1-30-8-6-14(7-9-30)13-26-19-18-17(31(2)10-11-33-18)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161971
PNG
(US9682991, 20)
Show SMILES CN1CCOc2c(N[C@H]3CC[C@H](O)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-9-10-32-17-16(29)20-27-26-19(12-3-2-4-15(11-12)33-21(22,23)24)30(20)28-18(17)25-13-5-7-14(31)8-6-13/h2-4,11,13-14,31H,5-10H2,1H3,(H,25,28)/t13-,14-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161975
PNG
(US9682991, 24)
Show SMILES COc1ccc(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(OC(F)(F)F)c2)cc1OC
Show InChI InChI=1S/C24H23F3N6O4/c1-32-9-10-36-20-19(32)21(28-13-14-7-8-17(34-2)18(11-14)35-3)31-33-22(29-30-23(20)33)15-5-4-6-16(12-15)37-24(25,26)27/h4-8,11-12H,9-10,13H2,1-3H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161983
PNG
(US9682991, 32)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N7O/c1-30-8-6-14(7-9-30)13-26-19-17-18(33-11-10-31(17)2)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161991
PNG
(US9682991, 40)
Show SMILES CC1CN(C)c2c(NCC3CCN(C)CC3)nn3c(nnc3c2O1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-13-32(3)18-19(34-14)22-29-28-21(16-5-4-6-17(11-16)35-23(24,25)26)33(22)30-20(18)27-12-15-7-9-31(2)10-8-15/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162028
PNG
(US9682991, 84)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2ccc(O)cc2)CC1
Show InChI InChI=1S/C21H27N7O2/c1-26-9-7-14(8-10-26)13-22-19-17-18(30-12-11-27(17)2)21-24-23-20(28(21)25-19)15-3-5-16(29)6-4-15/h3-6,14,29H,7-13H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162030
PNG
(US9682991, 86)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)23-20-19(32(3)11-12-35-20)22-30-29-21(34(22)31-23)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161946
PNG
(US9682991, 7)
Show SMILES CN1CCOc2c1c(NCC1CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N6O2/c1-27-7-8-29-15-14(27)16(23-10-11-5-6-11)26-28-17(24-25-18(15)28)12-3-2-4-13(9-12)30-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161977
PNG
(US9682991, 26)
Show SMILES CN1CCOc2c1c(NCCc1cccnc1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O2/c1-31-10-11-33-18-17(31)19(27-9-7-14-4-3-8-26-13-14)30-32-20(28-29-21(18)32)15-5-2-6-16(12-15)34-22(23,24)25/h2-6,8,12-13H,7,9-11H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161980
PNG
(US9682991, 29)
Show SMILES CN1CCOc2c1c(NCCN1CCOCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O3/c1-29-7-12-33-17-16(29)18(25-5-6-30-8-10-32-11-9-30)28-31-19(26-27-20(17)31)14-3-2-4-15(13-14)34-21(22,23)24/h2-4,13H,5-12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161985
PNG
(US9682991, 34)
Show SMILES CN(C)c1cccc(c1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(C)CC3)nn12
Show InChI InChI=1S/C23H32N8O/c1-28(2)18-7-5-6-17(14-18)22-25-26-23-20-19(30(4)12-13-32-20)21(27-31(22)23)24-15-16-8-10-29(3)11-9-16/h5-7,14,16H,8-13,15H2,1-4H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162027
PNG
(US9682991, 83)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CC2(C1)CCNCC2
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)19-28-27-18(14-3-2-4-15(11-14)34-22(23,24)25)32(19)29-20(17)31-12-21(13-31)5-7-26-8-6-21/h2-4,11,26H,5-10,12-13H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162044
PNG
(US9682991, 98)
Show SMILES CN(CCN1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O3/c1-29-8-13-34-18-17(29)20(30(2)6-7-31-9-11-33-12-10-31)28-32-19(26-27-21(18)32)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162044
PNG
(US9682991, 98)
Show SMILES CN(CCN1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O3/c1-29-8-13-34-18-17(29)20(30(2)6-7-31-9-11-33-12-10-31)28-32-19(26-27-21(18)32)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161937
PNG
(US9682991, 1)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(C)CC3)nn12
Show InChI InChI=1S/C22H29N7O2/c1-27-10-8-15(9-11-27)14-23-20-18-19(31-13-12-28(18)2)22-25-24-21(29(22)26-20)16-4-6-17(30-3)7-5-16/h4-7,15H,8-14H2,1-3H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161938
PNG
(US9682991, 2)
Show SMILES CN1CCC(CC1)Nc1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-8-6-14(7-9-29)25-18-16-17(32-11-10-30(16)2)20-27-26-19(31(20)28-18)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161990
PNG
(US9682991, 39)
Show SMILES CC1COc2c(N1C)c(NCC1CCN(C)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-13-34-19-18(32(14)3)20(27-12-15-7-9-31(2)10-8-15)30-33-21(28-29-22(19)33)16-5-4-6-17(11-16)35-23(24,25)26/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162000
PNG
(US9682991, 53)
Show SMILES CN1CCOc2c(NCC34CCN(CC3)C4)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)20-28-27-19(14-3-2-4-15(11-14)34-22(23,24)25)32(20)29-18(17)26-12-21-5-7-31(13-21)8-6-21/h2-4,11H,5-10,12-13H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162056
PNG
(US9682991, 58)
Show SMILES CN1CCOc2c(NCC3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)20-28-27-19(14-3-2-4-15(11-14)33-21(22,23)24)31(20)29-18(17)26-12-13-5-7-25-8-6-13/h2-4,11,13,25H,5-10,12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162030
PNG
(US9682991, 86)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)23-20-19(32(3)11-12-35-20)22-30-29-21(34(22)31-23)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162047
PNG
(US9682991, 101)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(nn12)N1CCCCC1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)30-13-6-4-5-12(11-13)16-23-24-17-14-15(29-10-9-28-14)18(25-27(16)17)26-7-2-1-3-8-26/h4-6,11H,1-3,7-10H2
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161939
PNG
(US9682991, 3)
Show SMILES CN1CCC(CC1)Nc1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-8-6-14(7-9-29)25-18-17-16(30(2)10-11-32-17)20-27-26-19(31(20)28-18)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161972
PNG
(US9682991, 21)
Show SMILES CN1CCOc2c1c(NCCCO)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N6O3/c1-26-7-9-29-14-13(26)15(22-6-3-8-28)25-27-16(23-24-17(14)27)11-4-2-5-12(10-11)30-18(19,20)21/h2,4-5,10,28H,3,6-9H2,1H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161989
PNG
(US9682991, 38)
Show SMILES CC1COc2c(NCC3CCN(C)CC3)nn3c(nnc3c2N1C)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-13-34-19-18(32(14)3)22-29-28-21(16-5-4-6-17(11-16)35-23(24,25)26)33(22)30-20(19)27-12-15-7-9-31(2)10-8-15/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161992
PNG
(US9682991, 41)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-7-5-13(6-8-29)12-25-18-16-17(32-10-9-31-16)20-27-26-19(30(20)28-18)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161995
PNG
(US9682991, 44)
Show SMILES CNC1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-25-14-6-8-30(9-7-14)20-17-16(29(2)10-11-32-17)19-27-26-18(31(19)28-20)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162051
PNG
(US9682991, 47)
Show SMILES CN1CCOc2c(NC3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H22F3N7O2/c1-29-9-10-31-16-15(29)19-27-26-18(12-3-2-4-14(11-12)32-20(21,22)23)30(19)28-17(16)25-13-5-7-24-8-6-13/h2-4,11,13,24H,5-10H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162057
PNG
(US9682991, 61)
Show SMILES CN1CCCC11CCCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-32-14-15-36-20-19(32)22(34-12-5-9-24(10-13-34)8-4-11-33(24)2)31-35-21(29-30-23(20)35)17-6-3-7-18(16-17)37-25(26,27)28/h3,6-7,16H,4-5,8-15H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162042
PNG
(US9682991, 96)
Show SMILES CN1CCOc2c(NCN(CCN3CCNCC3)S(C)(=O)=O)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H30F3N9O4S/c1-32-12-13-38-19-18(32)22-30-29-21(16-4-3-5-17(14-16)39-23(24,25)26)35(22)31-20(19)28-15-34(40(2,36)37)11-10-33-8-6-27-7-9-33/h3-5,14,27H,6-13,15H2,1-2H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161938
PNG
(US9682991, 2)
Show SMILES CN1CCC(CC1)Nc1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-8-6-14(7-9-29)25-18-16-17(32-11-10-30(16)2)20-27-26-19(31(20)28-18)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161942
PNG
(US9682991, 5)
Show SMILES CN(C)C1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-29(2)15-7-9-31(10-8-15)20-17-18(33-12-11-30(17)3)21-27-26-19(32(21)28-20)14-5-4-6-16(13-14)34-22(23,24)25/h4-6,13,15H,7-12H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161960
PNG
(US9682991, 13)
Show SMILES CCN1CCOc2c(NCC3CCN(C)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-3-32-11-12-34-19-18(32)22-29-28-21(16-5-4-6-17(13-16)35-23(24,25)26)33(22)30-20(19)27-14-15-7-9-31(2)10-8-15/h4-6,13,15H,3,7-12,14H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161971
PNG
(US9682991, 20)
Show SMILES CN1CCOc2c(N[C@H]3CC[C@H](O)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-9-10-32-17-16(29)20-27-26-19(12-3-2-4-15(11-12)33-21(22,23)24)30(20)28-18(17)25-13-5-7-14(31)8-6-13/h2-4,11,13-14,31H,5-10H2,1H3,(H,25,28)/t13-,14-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161977
PNG
(US9682991, 26)
Show SMILES CN1CCOc2c1c(NCCc1cccnc1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O2/c1-31-10-11-33-18-17(31)19(27-9-7-14-4-3-8-26-13-14)30-32-20(28-29-21(18)32)15-5-2-6-16(12-15)34-22(23,24)25/h2-6,8,12-13H,7,9-11H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161980
PNG
(US9682991, 29)
Show SMILES CN1CCOc2c1c(NCCN1CCOCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O3/c1-29-7-12-33-17-16(29)18(25-5-6-30-8-10-32-11-9-30)28-31-19(26-27-20(17)31)14-3-2-4-15(13-14)34-21(22,23)24/h2-4,13H,5-12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161982
PNG
(US9682991, 31)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C22H26N8O/c1-28-8-6-15(7-9-28)14-24-20-18-19(31-11-10-29(18)2)22-26-25-21(30(22)27-20)17-5-3-4-16(12-17)13-23/h3-5,12,15H,6-11,14H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162016
PNG
(US9682991, 72)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3N(C)C(C)(C)COc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C24H30F3N7O2/c1-23(2)14-35-19-18(33(23)4)22-30-29-21(16-6-5-7-17(12-16)36-24(25,26)27)34(22)31-20(19)28-13-15-8-10-32(3)11-9-15/h5-7,12,15H,8-11,13-14H2,1-4H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162038
PNG
(US9682991, 94)
Show SMILES CN1CCN(C)c2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1ccc(O)cc1
Show InChI InChI=1S/C22H22FN7O/c1-28-11-12-29(2)19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-30-21(25-26-22(19)30)15-5-9-17(31)10-6-15/h3-10,31H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161962
PNG
(US9682991, 14)
Show SMILES CCN1CCOc2c(NC3CCOCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-2-29-8-11-32-17-16(29)20-27-26-19(13-4-3-5-15(12-13)33-21(22,23)24)30(20)28-18(17)25-14-6-9-31-10-7-14/h3-5,12,14H,2,6-11H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161973
PNG
(US9682991, 22)
Show SMILES CN1CCOc2c(NCCCO)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N6O3/c1-26-7-9-29-14-13(26)17-24-23-16(27(17)25-15(14)22-6-3-8-28)11-4-2-5-12(10-11)30-18(19,20)21/h2,4-5,10,28H,3,6-9H2,1H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161940
PNG
(US9682991, 4)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCCN3CCOCC3)nn12
Show InChI InChI=1S/C21H27N7O3/c1-26-9-14-31-18-17(26)19(22-7-8-27-10-12-30-13-11-27)25-28-20(23-24-21(18)28)15-3-5-16(29-2)6-4-15/h3-6H,7-14H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161952
PNG
(US9682991, 10)
Show SMILES CN1CCOc2c(NCc3ccc(F)cc3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H18F4N6O2/c1-31-9-10-33-18-17(31)21-29-28-20(14-3-2-4-16(11-14)34-22(24,25)26)32(21)30-19(18)27-12-13-5-7-15(23)8-6-13/h2-8,11H,9-10,12H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161968
PNG
(US9682991, 17)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3N(C)CCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H26F3N7O2/c1-30-8-6-14(7-9-30)13-26-19-18-17(31(2)10-11-33-18)21-28-27-20(32(21)29-19)15-4-3-5-16(12-15)34-22(23,24)25/h3-5,12,14H,6-11,13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161969
PNG
(US9682991, 18)
Show SMILES CN(CC1CCN(C)CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-30-9-7-15(8-10-30)14-32(3)22-19-18(31(2)11-12-34-19)21-28-27-20(33(21)29-22)16-5-4-6-17(13-16)35-23(24,25)26/h4-6,13,15H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161971
PNG
(US9682991, 20)
Show SMILES CN1CCOc2c(N[C@H]3CC[C@H](O)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-9-10-32-17-16(29)20-27-26-19(12-3-2-4-15(11-12)33-21(22,23)24)30(20)28-18(17)25-13-5-7-14(31)8-6-13/h2-4,11,13-14,31H,5-10H2,1H3,(H,25,28)/t13-,14-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162003
PNG
(US9682991, 57)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19-27-26-18(14-3-2-4-15(11-14)33-21(22,23)24)31(19)28-20(17)30-7-5-13(12-25)6-8-30/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162030
PNG
(US9682991, 86)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)23-20-19(32(3)11-12-35-20)22-30-29-21(34(22)31-23)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162033
PNG
(US9682991, 89)
Show SMILES CN1CCOc2c(NCC3CCN(CC4CC4)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)24-31-30-23(18-3-2-4-19(13-18)37-25(26,27)28)35(24)32-22(21)29-14-16-7-9-34(10-8-16)15-17-5-6-17/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161940
PNG
(US9682991, 4)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCCN3CCOCC3)nn12
Show InChI InChI=1S/C21H27N7O3/c1-26-9-14-31-18-17(26)19(22-7-8-27-10-12-30-13-11-27)25-28-20(23-24-21(18)28)15-3-5-16(29-2)6-4-15/h3-6H,7-14H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM161978
PNG
(US9682991, 27)
Show SMILES CN1CCN(CCNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H27F3N8O2/c1-30-8-10-32(11-9-30)7-6-26-19-17-18(34-13-12-31(17)2)21-28-27-20(33(21)29-19)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161952
PNG
(US9682991, 10)
Show SMILES CN1CCOc2c(NCc3ccc(F)cc3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H18F4N6O2/c1-31-9-10-33-18-17(31)21-29-28-20(14-3-2-4-16(11-14)34-22(24,25)26)32(21)30-19(18)27-12-13-5-7-15(23)8-6-13/h2-8,11H,9-10,12H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162050
PNG
(US9682991, 45)
Show SMILES CN(C1CCNCC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-10-11-32-17-16(29)19-27-26-18(13-4-3-5-15(12-13)33-21(22,23)24)31(19)28-20(17)30(2)14-6-8-25-9-7-14/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162000
PNG
(US9682991, 53)
Show SMILES CN1CCOc2c(NCC34CCN(CC3)C4)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)20-28-27-19(14-3-2-4-15(11-14)34-22(23,24)25)32(20)29-18(17)26-12-21-5-7-31(13-21)8-6-21/h2-4,11H,5-10,12-13H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162027
PNG
(US9682991, 83)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CC2(C1)CCNCC2
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)19-28-27-18(14-3-2-4-15(11-14)34-22(23,24)25)32(19)29-20(17)31-12-21(13-31)5-7-26-8-6-21/h2-4,11,26H,5-10,12-13H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161981
PNG
(US9682991, 30)
Show SMILES CN1CCOc2c(NCCN3CCOCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O3/c1-29-7-12-33-17-16(29)20-27-26-19(14-3-2-4-15(13-14)34-21(22,23)24)31(20)28-18(17)25-5-6-30-8-10-32-11-9-30/h2-4,13H,5-12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161984
PNG
(US9682991, 33)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2ccc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C23H28N8O/c1-29-9-6-15(7-10-29)14-25-21-19-20(32-12-11-30(19)2)23-27-26-22(31(23)28-21)17-3-4-18-16(13-17)5-8-24-18/h3-5,8,13,15,24H,6-7,9-12,14H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161995
PNG
(US9682991, 44)
Show SMILES CNC1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-25-14-6-8-30(9-7-14)20-17-16(29(2)10-11-32-17)19-27-26-18(31(19)28-20)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14,25H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162054
PNG
(US9682991, 52)
Show SMILES COc1cccc(c1)-c1nnc2c3OCCN(C)c3c(NC3CCNCC3)nn12
Show InChI InChI=1S/C20H25N7O2/c1-26-10-11-29-17-16(26)18(22-14-6-8-21-9-7-14)25-27-19(23-24-20(17)27)13-4-3-5-15(12-13)28-2/h3-5,12,14,21H,6-11H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162001
PNG
(US9682991, 54)
Show SMILES CN1CCOc2c1c(NCC13CCN(CC1)C3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)18(26-12-21-5-7-31(13-21)8-6-21)29-32-19(27-28-20(17)32)14-3-2-4-15(11-14)34-22(23,24)25/h2-4,11H,5-10,12-13H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162025
PNG
(US9682991, 81)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162038
PNG
(US9682991, 94)
Show SMILES CN1CCN(C)c2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1ccc(O)cc1
Show InChI InChI=1S/C22H22FN7O/c1-28-11-12-29(2)19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-30-21(25-26-22(19)30)15-5-9-17(31)10-6-15/h3-10,31H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162042
PNG
(US9682991, 96)
Show SMILES CN1CCOc2c(NCN(CCN3CCNCC3)S(C)(=O)=O)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H30F3N9O4S/c1-32-12-13-38-19-18(32)22-30-29-21(16-4-3-5-17(14-16)39-23(24,25)26)35(22)31-20(19)28-15-34(40(2,36)37)11-10-33-8-6-27-7-9-33/h3-5,14,27H,6-13,15H2,1-2H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161943
PNG
(US9682991, 6)
Show SMILES CN(C)C1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-29(2)15-7-9-31(10-8-15)21-18-17(30(3)11-12-33-18)20-27-26-19(32(20)28-21)14-5-4-6-16(13-14)34-22(23,24)25/h4-6,13,15H,7-12H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161960
PNG
(US9682991, 13)
Show SMILES CCN1CCOc2c(NCC3CCN(C)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-3-32-11-12-34-19-18(32)22-29-28-21(16-5-4-6-17(13-16)35-23(24,25)26)33(22)30-20(19)27-14-15-7-9-31(2)10-8-15/h4-6,13,15H,3,7-12,14H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161963
PNG
(US9682991, 15)
Show SMILES COc1ccc(cc1)-c1nnc2c3N(C)CCN(C)c3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C23H24FN7O/c1-29-12-13-30(2)20-19(29)21(25-14-15-4-8-17(24)9-5-15)28-31-22(26-27-23(20)31)16-6-10-18(32-3)11-7-16/h4-11H,12-14H2,1-3H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161975
PNG
(US9682991, 24)
Show SMILES COc1ccc(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(OC(F)(F)F)c2)cc1OC
Show InChI InChI=1S/C24H23F3N6O4/c1-32-9-10-36-20-19(32)21(28-13-14-7-8-17(34-2)18(11-14)35-3)31-33-22(29-30-23(20)33)15-5-4-6-16(12-15)37-24(25,26)27/h4-8,11-12H,9-10,13H2,1-3H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161978
PNG
(US9682991, 27)
Show SMILES CN1CCN(CCNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H27F3N8O2/c1-30-8-10-32(11-9-30)7-6-26-19-17-18(34-13-12-31(17)2)21-28-27-20(33(21)29-19)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161979
PNG
(US9682991, 28)
Show SMILES CN1CCN(CCNc2nn3c(nnc3c3N(C)CCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H27F3N8O2/c1-30-8-10-32(11-9-30)7-6-26-19-18-17(31(2)12-13-34-18)21-28-27-20(33(21)29-19)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161982
PNG
(US9682991, 31)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C22H26N8O/c1-28-8-6-15(7-9-28)14-24-20-18-19(31-11-10-29(18)2)22-26-25-21(30(22)27-20)17-5-3-4-16(12-17)13-23/h3-5,12,15H,6-11,14H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161996
PNG
(US9682991, 46)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C20H22F3N7O2/c1-28-9-10-31-16-15(28)18-26-25-17(12-3-2-4-14(11-12)32-20(21,22)23)30(18)27-19(16)29-7-5-13(24)6-8-29/h2-4,11,13H,5-10,24H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161999
PNG
(US9682991, 51)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(CC3)C(=O)OC(C)(C)C)nn12
Show InChI InChI=1S/C26H35N7O4/c1-26(2,3)37-25(34)32-12-10-17(11-13-32)16-27-22-20-21(36-15-14-31(20)4)24-29-28-23(33(24)30-22)18-6-8-19(35-5)9-7-18/h6-9,17H,10-16H2,1-5H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162016
PNG
(US9682991, 72)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3N(C)C(C)(C)COc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C24H30F3N7O2/c1-23(2)14-35-19-18(33(23)4)22-30-29-21(16-6-5-7-17(12-16)36-24(25,26)27)34(22)31-20(19)28-13-15-8-10-32(3)11-9-15/h5-7,12,15H,8-11,13-14H2,1-4H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162022
PNG
(US9682991, 79)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC1)C(=O)OC(C)(C)C)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H32F3N7O4/c1-25(2,3)40-24(37)35-10-8-16(9-11-35)15-30-21-19-20(38-13-12-34(19)4)23-32-31-22(36(23)33-21)17-6-5-7-18(14-17)39-26(27,28)29/h5-7,14,16H,8-13,15H2,1-4H3,(H,30,33)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162032
PNG
(US9682991, 88)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC3CC3)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)22(29-14-16-7-9-34(10-8-16)15-17-5-6-17)32-35-23(30-31-24(21)35)18-3-2-4-19(13-18)37-25(26,27)28/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162032
PNG
(US9682991, 88)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC3CC3)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)22(29-14-16-7-9-34(10-8-16)15-17-5-6-17)32-35-23(30-31-24(21)35)18-3-2-4-19(13-18)37-25(26,27)28/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162040
PNG
(US9682991, 95)
Show SMILES CN1CCOc2c(NCCN3CCN(CC3)C(C)=O)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27F3N8O3/c1-15(35)33-10-8-32(9-11-33)7-6-27-20-19-18(31(2)12-13-36-19)22-29-28-21(34(22)30-20)16-4-3-5-17(14-16)37-23(24,25)26/h3-5,14H,6-13H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162049
PNG
(US9682991, 103)
Show InChI InChI=1S/C21H24F3N7O3/c1-29-8-11-33-17-16(29)18(25-14-6-9-31(2,32)10-7-14)28-30-19(26-27-20(17)30)13-4-3-5-15(12-13)34-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161943
PNG
(US9682991, 6)
Show SMILES CN(C)C1CCN(CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-29(2)15-7-9-31(10-8-15)21-18-17(30(3)11-12-33-18)20-27-26-19(32(20)28-21)14-5-4-6-16(13-14)34-22(23,24)25/h4-6,13,15H,7-12H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161962
PNG
(US9682991, 14)
Show SMILES CCN1CCOc2c(NC3CCOCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-2-29-8-11-32-17-16(29)20-27-26-19(13-4-3-5-15(12-13)33-21(22,23)24)30(20)28-18(17)25-14-6-9-31-10-7-14/h3-5,12,14H,2,6-11H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161979
PNG
(US9682991, 28)
Show SMILES CN1CCN(CCNc2nn3c(nnc3c3N(C)CCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H27F3N8O2/c1-30-8-10-32(11-9-30)7-6-26-19-18-17(31(2)12-13-34-18)21-28-27-20(33(21)29-19)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161981
PNG
(US9682991, 30)
Show SMILES CN1CCOc2c(NCCN3CCOCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O3/c1-29-7-12-33-17-16(29)20-27-26-19(14-3-2-4-15(13-14)34-21(22,23)24)31(20)28-18(17)25-5-6-30-8-10-32-11-9-30/h2-4,13H,5-12H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161999
PNG
(US9682991, 51)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(CC3)C(=O)OC(C)(C)C)nn12
Show InChI InChI=1S/C26H35N7O4/c1-26(2,3)37-25(34)32-12-10-17(11-13-32)16-27-22-20-21(36-15-14-31(20)4)24-29-28-23(33(24)30-22)18-6-8-19(35-5)9-7-18/h6-9,17H,10-16H2,1-5H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162010
PNG
(US9682991, 66)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1S/C23H26F3N7O2/c1-31-9-10-34-18-17(31)20-29-28-19(14-3-2-4-16(11-14)35-23(24,25)26)33(20)30-21(18)32-7-5-22(6-8-32)12-15(27)13-22/h2-4,11,15H,5-10,12-13,27H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162024
PNG
(US9682991, 80)
Show SMILES COc1ccc(cc1)-c1nnc2c3N(C)CCOc3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)22-26-25-21(15-5-9-17(30-2)10-6-15)29(22)27-20(19)24-13-14-3-7-16(23)8-4-14/h3-10H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162024
PNG
(US9682991, 80)
Show SMILES COc1ccc(cc1)-c1nnc2c3N(C)CCOc3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)22-26-25-21(15-5-9-17(30-2)10-6-15)29(22)27-20(19)24-13-14-3-7-16(23)8-4-14/h3-10H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162028
PNG
(US9682991, 84)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2ccc(O)cc2)CC1
Show InChI InChI=1S/C21H27N7O2/c1-26-9-7-14(8-10-26)13-22-19-17-18(30-12-11-27(17)2)21-24-23-20(28(21)25-19)15-3-5-16(29)6-4-15/h3-6,14,29H,7-13H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162033
PNG
(US9682991, 89)
Show SMILES CN1CCOc2c(NCC3CCN(CC4CC4)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)24-31-30-23(18-3-2-4-19(13-18)37-25(26,27)28)35(24)32-22(21)29-14-16-7-9-34(10-8-16)15-17-5-6-17/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162036
PNG
(US9682991, 92)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(nn12)N1CCC(CNC(C)=O)CC1
Show InChI InChI=1S/C23H29N7O3/c1-15(31)24-14-16-8-10-29(11-9-16)22-19-20(33-13-12-28(19)2)23-26-25-21(30(23)27-22)17-4-6-18(32-3)7-5-17/h4-7,16H,8-14H2,1-3H3,(H,24,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162036
PNG
(US9682991, 92)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(nn12)N1CCC(CNC(C)=O)CC1
Show InChI InChI=1S/C23H29N7O3/c1-15(31)24-14-16-8-10-29(11-9-16)22-19-20(33-13-12-28(19)2)23-26-25-21(30(23)27-22)17-4-6-18(32-3)7-5-17/h4-7,16H,8-14H2,1-3H3,(H,24,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161947
PNG
(US9682991, 8)
Show SMILES CN1CCOc2c(NCC3CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N6O2/c1-27-7-8-29-15-14(27)18-25-24-17(28(18)26-16(15)23-10-11-5-6-11)12-3-2-4-13(9-12)30-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


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More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161985
PNG
(US9682991, 34)
Show SMILES CN(C)c1cccc(c1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(C)CC3)nn12
Show InChI InChI=1S/C23H32N8O/c1-28(2)18-7-5-6-17(14-18)22-25-26-23-20-19(30(4)12-13-32-20)21(27-31(22)23)24-15-16-8-10-29(3)11-9-16/h5-7,14,16H,8-13,15H2,1-4H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161993
PNG
(US9682991, 42)
Show SMILES CN1CCOc2c(NCCN3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H25F3N8O2/c1-30-11-12-33-17-16(30)20-28-27-19(14-3-2-4-15(13-14)34-21(22,23)24)32(20)29-18(17)26-7-10-31-8-5-25-6-9-31/h2-4,13,25H,5-12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162054
PNG
(US9682991, 52)
Show SMILES COc1cccc(c1)-c1nnc2c3OCCN(C)c3c(NC3CCNCC3)nn12
Show InChI InChI=1S/C20H25N7O2/c1-26-10-11-29-17-16(26)18(22-14-6-8-21-9-7-14)25-27-19(23-24-20(17)27)13-4-3-5-15(12-13)28-2/h3-5,12,14,21H,6-11H2,1-2H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM162003
PNG
(US9682991, 57)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19-27-26-18(14-3-2-4-15(11-14)33-21(22,23)24)31(19)28-20(17)30-7-5-13(12-25)6-8-30/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162046
PNG
(US9682991, 100)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCN(C)c23)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H26FN7O/c1-27-9-7-14(8-10-27)13-23-19-17-18(30-12-11-28(17)2)21-25-24-20(29(21)26-19)15-3-5-16(22)6-4-15/h3-6,14H,7-13H2,1-2H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161937
PNG
(US9682991, 1)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(C)CC3)nn12
Show InChI InChI=1S/C22H29N7O2/c1-27-10-8-15(9-11-27)14-23-20-18-19(31-13-12-28(18)2)22-25-24-21(29(22)26-20)16-4-6-17(30-3)7-5-16/h4-7,15H,8-14H2,1-3H3,(H,23,26)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161939
PNG
(US9682991, 3)
Show SMILES CN1CCC(CC1)Nc1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-8-6-14(7-9-29)25-18-17-16(30(2)10-11-32-17)20-27-26-19(31(20)28-18)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161950
PNG
(US9682991, 9)
Show SMILES CN1CCOc2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H18F4N6O2/c1-31-9-10-33-18-17(31)19(27-12-13-5-7-15(23)8-6-13)30-32-20(28-29-21(18)32)14-3-2-4-16(11-14)34-22(24,25)26/h2-8,11H,9-10,12H2,1H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161969
PNG
(US9682991, 18)
Show SMILES CN(CC1CCN(C)CC1)c1nn2c(nnc2c2N(C)CCOc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H28F3N7O2/c1-30-9-7-15(8-10-30)14-32(3)22-19-18(31(2)11-12-34-19)21-28-27-20(33(21)29-22)16-5-4-6-17(13-16)35-23(24,25)26/h4-6,13,15H,7-12,14H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM161973
PNG
(US9682991, 22)
Show SMILES CN1CCOc2c(NCCCO)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N6O3/c1-26-7-9-29-14-13(26)17-24-23-16(27(17)25-15(14)22-6-3-8-28)11-4-2-5-12(10-11)30-18(19,20)21/h2,4-5,10,28H,3,6-9H2,1H3,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162051
PNG
(US9682991, 47)
Show SMILES CN1CCOc2c(NC3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H22F3N7O2/c1-29-9-10-31-16-15(29)19-27-26-18(12-3-2-4-14(11-12)32-20(21,22)23)30(19)28-17(16)25-13-5-7-24-8-6-13/h2-4,11,13,24H,5-10H2,1H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162056
PNG
(US9682991, 58)
Show SMILES CN1CCOc2c(NCC3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)20-28-27-19(14-3-2-4-15(11-14)33-21(22,23)24)31(20)29-18(17)26-12-13-5-7-25-8-6-13/h2-4,11,13,25H,5-10,12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM162040
PNG
(US9682991, 95)
Show SMILES CN1CCOc2c(NCCN3CCN(CC3)C(C)=O)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27F3N8O3/c1-15(35)33-10-8-32(9-11-33)7-6-27-20-19-18(31(2)12-13-36-19)22-29-28-21(34(22)30-20)16-4-3-5-17(14-16)37-23(24,25)26/h3-5,14H,6-13H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161963
PNG
(US9682991, 15)
Show SMILES COc1ccc(cc1)-c1nnc2c3N(C)CCN(C)c3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C23H24FN7O/c1-29-12-13-30(2)20-19(29)21(25-14-15-4-8-17(24)9-5-15)28-31-22(26-27-23(20)31)16-6-10-18(32-3)11-7-16/h4-11H,12-14H2,1-3H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%