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Patent code US9687483

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2 (ROCK II)


(Rattus norvegicus (Rat))
BDBM14027
PNG
(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
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Article
US Patent
n/an/a 820n/an/an/an/an/an/a



BIOAXONE BIOSCIENCES, INC.

US Patent


Assay Description
The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...


US Patent US9687483 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK II)


(Rattus norvegicus (Rat))
BDBM163433
PNG
(BA-1049 | US9687483, 1)
Show SMILES C[C@@H](N)C1CCN(CC1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C16H21N3O2S/c1-12(17)13-6-9-19(10-7-13)22(20,21)16-4-2-3-14-11-18-8-5-15(14)16/h2-5,8,11-13H,6-7,9-10,17H2,1H3/t12-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 940n/an/an/an/an/an/a



BIOAXONE BIOSCIENCES, INC.

US Patent


Assay Description
The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...


US Patent US9687483 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK II)


(Rattus norvegicus (Rat))
BDBM163433
PNG
(BA-1049 | US9687483, 1)
Show SMILES C[C@@H](N)C1CCN(CC1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C16H21N3O2S/c1-12(17)13-6-9-19(10-7-13)22(20,21)16-4-2-3-14-11-18-8-5-15(14)16/h2-5,8,11-13H,6-7,9-10,17H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



BIOAXONE BIOSCIENCES, INC.

US Patent


Assay Description
The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...


US Patent US9687483 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK I)


(Rattus norvegicus (Rat))
BDBM14027
PNG
(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
PDB

UniProtKB/SwissProt

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PC cid
PC sid
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UniChem

Patents


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Article
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



BIOAXONE BIOSCIENCES, INC.

US Patent


Assay Description
The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...


US Patent US9687483 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK I)


(Rattus norvegicus (Rat))
BDBM163433
PNG
(BA-1049 | US9687483, 1)
Show SMILES C[C@@H](N)C1CCN(CC1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C16H21N3O2S/c1-12(17)13-6-9-19(10-7-13)22(20,21)16-4-2-3-14-11-18-8-5-15(14)16/h2-5,8,11-13H,6-7,9-10,17H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.10E+4n/an/an/an/an/an/a



BIOAXONE BIOSCIENCES, INC.

US Patent


Assay Description
The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...


US Patent US9687483 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%