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Patent code US9688642

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168191
PNG
(US9688642, 2)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C
Show InChI InChI=1S/C27H30FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,10-11,13-14,16-17,21H,7-9,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168170
PNG
(US9688642, 3)
Show SMILES CCCCc1nc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cnc1-c1cc(OC)ccc1F
Show InChI InChI=1S/C28H31FN2O4/c1-3-4-8-26-28(24-14-21(34-2)11-12-25(24)29)30-16-20(31-26)17-35-22-7-5-6-19(13-22)23(15-27(32)33)18-9-10-18/h5-7,11-14,16,18,23H,3-4,8-10,15,17H2,1-2H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168173
PNG
(US9688642, 4)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)(C)C
Show InChI InChI=1S/C29H33FN2O5/c1-29(2,3)17-37-28-27(24-13-21(35-4)10-11-25(24)30)31-15-20(32-28)16-36-22-7-5-6-19(12-22)23(14-26(33)34)18-8-9-18/h5-7,10-13,15,18,23H,8-9,14,16-17H2,1-4H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168172
PNG
(US9688642, 21)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1CC1
Show InChI InChI=1S/C28H29FN2O5/c1-34-21-9-10-25(29)24(12-21)27-28(36-15-17-5-6-17)31-20(14-30-27)16-35-22-4-2-3-19(11-22)23(13-26(32)33)18-7-8-18/h2-4,9-12,14,17-18,23H,5-8,13,15-16H2,1H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168153
PNG
(US9688642, 23)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cccc(c1)C(C)C
Show InChI InChI=1S/C33H33FN2O4/c1-20(2)22-6-4-8-24(14-22)32-33(29-16-26(39-3)12-13-30(29)34)35-18-25(36-32)19-40-27-9-5-7-23(15-27)28(17-31(37)38)21-10-11-21/h4-9,12-16,18,20-21,28H,10-11,17,19H2,1-3H3,(H,37,38)/t28-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168153
PNG
(US9688642, 23)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cccc(c1)C(C)C
Show InChI InChI=1S/C33H33FN2O4/c1-20(2)22-6-4-8-24(14-22)32-33(29-16-26(39-3)12-13-30(29)34)35-18-25(36-32)19-40-27-9-5-7-23(15-27)28(17-31(37)38)21-10-11-21/h4-9,12-16,18,20-21,28H,10-11,17,19H2,1-3H3,(H,37,38)/t28-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168188
PNG
(US9688642, 29)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC(C)C
Show InChI InChI=1S/C27H29FN2O5/c1-16(2)35-27-26(23-12-20(33-3)9-10-24(23)28)29-14-19(30-27)15-34-21-6-4-5-18(11-21)22(13-25(31)32)17-7-8-17/h4-6,9-12,14,16-17,22H,7-8,13,15H2,1-3H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168176
PNG
(US9688642, 38)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N(C)C
Show InChI InChI=1S/C26H28FN3O4/c1-30(2)26-25(22-12-19(33-3)9-10-23(22)27)28-14-18(29-26)15-34-20-6-4-5-17(11-20)21(13-24(31)32)16-7-8-16/h4-6,9-12,14,16,21H,7-8,13,15H2,1-3H3,(H,31,32)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168171
PNG
(US9688642, 1)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)(C)C
Show InChI InChI=1S/C29H33FN2O4/c1-29(2,3)15-26-28(24-13-21(35-4)10-11-25(24)30)31-16-20(32-26)17-36-22-7-5-6-19(12-22)23(14-27(33)34)18-8-9-18/h5-7,10-13,16,18,23H,8-9,14-15,17H2,1-4H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168177
PNG
(US9688642, 8)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C=C(C)C
Show InChI InChI=1S/C28H29FN2O4/c1-17(2)11-26-28(24-13-21(34-3)9-10-25(24)29)30-15-20(31-26)16-35-22-6-4-5-19(12-22)23(14-27(32)33)18-7-8-18/h4-6,9-13,15,18,23H,7-8,14,16H2,1-3H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168193
PNG
(US9688642, 9)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCCC1
Show InChI InChI=1S/C29H32FN3O5/c1-36-26-13-24(25(30)16-31-26)28-29(38-21-7-3-2-4-8-21)33-20(15-32-28)17-37-22-9-5-6-19(12-22)23(14-27(34)35)18-10-11-18/h5-6,9,12-13,15-16,18,21,23H,2-4,7-8,10-11,14,17H2,1H3,(H,34,35)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168159
PNG
(US9688642, 12)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)C
Show InChI InChI=1S/C27H30FN3O5/c1-16(2)14-36-27-26(22-10-24(34-3)29-13-23(22)28)30-12-19(31-27)15-35-20-6-4-5-18(9-20)21(11-25(32)33)17-7-8-17/h4-6,9-10,12-13,16-17,21H,7-8,11,14-15H2,1-3H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168182
PNG
(US9688642, 14)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)C
Show InChI InChI=1S/C28H31FN2O5/c1-17(2)15-36-28-27(24-12-21(34-3)9-10-25(24)29)30-14-20(31-28)16-35-22-6-4-5-19(11-22)23(13-26(32)33)18-7-8-18/h4-6,9-12,14,17-18,23H,7-8,13,15-16H2,1-3H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168184
PNG
(US9688642, 15 | US9688642, 30)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C30H32FN3O4/c1-30(2)11-5-8-24(30)29-28(23-13-26(37-3)32-16-25(23)31)33-15-20(34-29)17-38-21-7-4-6-19(12-21)22(14-27(35)36)18-9-10-18/h4,6-8,12-13,15-16,18,22H,5,9-11,14,17H2,1-3H3,(H,35,36)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168194
PNG
(US9688642, 16)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCC1
Show InChI InChI=1S/C28H30FN3O5/c1-35-25-12-23(24(29)15-30-25)27-28(37-20-6-2-3-7-20)32-19(14-31-27)16-36-21-8-4-5-18(11-21)22(13-26(33)34)17-9-10-17/h4-5,8,11-12,14-15,17,20,22H,2-3,6-7,9-10,13,16H2,1H3,(H,33,34)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168167
PNG
(US9688642, 19)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCC1
Show InChI InChI=1S/C28H29FN2O5/c1-34-21-10-11-25(29)24(13-21)27-28(36-20-5-3-6-20)31-19(15-30-27)16-35-22-7-2-4-18(12-22)23(14-26(32)33)17-8-9-17/h2,4,7,10-13,15,17,20,23H,3,5-6,8-9,14,16H2,1H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168157
PNG
(US9688642, 27)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCCCC1
Show InChI InChI=1S/C31H35FN2O5/c1-37-24-13-14-28(32)27(16-24)30-31(39-23-8-4-2-3-5-9-23)34-22(18-33-30)19-38-25-10-6-7-21(15-25)26(17-29(35)36)20-11-12-20/h6-7,10,13-16,18,20,23,26H,2-5,8-9,11-12,17,19H2,1H3,(H,35,36)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168163
PNG
(US9688642, 32)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCCC(F)(F)F
Show InChI InChI=1S/C27H26F4N2O5/c1-36-19-7-8-23(28)22(12-19)25-26(37-10-9-27(29,30)31)33-18(14-32-25)15-38-20-4-2-3-17(11-20)21(13-24(34)35)16-5-6-16/h2-4,7-8,11-12,14,16,21H,5-6,9-10,13,15H2,1H3,(H,34,35)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168187
PNG
(US9688642, 37)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C(C)C
Show InChI InChI=1S/C27H29FN2O4/c1-16(2)26-27(23-12-20(33-3)9-10-24(23)28)29-14-19(30-26)15-34-21-6-4-5-18(11-21)22(13-25(31)32)17-7-8-17/h4-6,9-12,14,16-17,22H,7-8,13,15H2,1-3H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168187
PNG
(US9688642, 37)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C(C)C
Show InChI InChI=1S/C27H29FN2O4/c1-16(2)26-27(23-12-20(33-3)9-10-24(23)28)29-14-19(30-26)15-34-21-6-4-5-18(11-21)22(13-25(31)32)17-7-8-17/h4-6,9-12,14,16-17,22H,7-8,13,15H2,1-3H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168170
PNG
(US9688642, 3)
Show SMILES CCCCc1nc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cnc1-c1cc(OC)ccc1F
Show InChI InChI=1S/C28H31FN2O4/c1-3-4-8-26-28(24-14-21(34-2)11-12-25(24)29)30-16-20(31-26)17-35-22-7-5-6-19(13-22)23(15-27(32)33)18-9-10-18/h5-7,11-14,16,18,23H,3-4,8-10,15,17H2,1-2H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168173
PNG
(US9688642, 4)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)(C)C
Show InChI InChI=1S/C29H33FN2O5/c1-29(2,3)17-37-28-27(24-13-21(35-4)10-11-25(24)30)31-15-20(32-28)16-36-22-7-5-6-19(12-22)23(14-26(33)34)18-8-9-18/h5-7,10-13,15,18,23H,8-9,14,16-17H2,1-4H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168162
PNG
(US9688642, 10)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cc(C)cc(C)c1
Show InChI InChI=1S/C32H31FN2O4/c1-19-11-20(2)13-23(12-19)31-32(28-15-25(38-3)9-10-29(28)33)34-17-24(35-31)18-39-26-6-4-5-22(14-26)27(16-30(36)37)21-7-8-21/h4-6,9-15,17,21,27H,7-8,16,18H2,1-3H3,(H,36,37)/t27-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168190
PNG
(US9688642, 11)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C=C(C)C
Show InChI InChI=1S/C27H28FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,9-11,13-14,17,21H,7-8,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168159
PNG
(US9688642, 12)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)C
Show InChI InChI=1S/C27H30FN3O5/c1-16(2)14-36-27-26(22-10-24(34-3)29-13-23(22)28)30-12-19(31-27)15-35-20-6-4-5-18(9-20)21(11-25(32)33)17-7-8-17/h4-6,9-10,12-13,16-17,21H,7-8,11,14-15H2,1-3H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168168
PNG
(US9688642, 18)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccccc1
Show InChI InChI=1S/C30H27FN2O4/c1-36-23-12-13-27(31)26(15-23)30-29(20-6-3-2-4-7-20)33-22(17-32-30)18-37-24-9-5-8-21(14-24)25(16-28(34)35)19-10-11-19/h2-9,12-15,17,19,25H,10-11,16,18H2,1H3,(H,34,35)/t25-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168172
PNG
(US9688642, 21)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1CC1
Show InChI InChI=1S/C28H29FN2O5/c1-34-21-9-10-25(29)24(12-21)27-28(36-15-17-5-6-17)31-20(14-30-27)16-35-22-4-2-3-19(11-22)23(13-26(32)33)18-7-8-18/h2-4,9-12,14,17-18,23H,5-8,13,15-16H2,1H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168184
PNG
(US9688642, 15 | US9688642, 30)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C30H32FN3O4/c1-30(2)11-5-8-24(30)29-28(23-13-26(37-3)32-16-25(23)31)33-15-20(34-29)17-38-21-7-4-6-19(12-21)22(14-27(35)36)18-9-10-18/h4,6-8,12-13,15-16,18,22H,5,9-11,14,17H2,1-3H3,(H,35,36)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168189
PNG
(US9688642, 36)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(C)s1
Show InChI InChI=1S/C29H27FN2O4S/c1-17-6-11-26(37-17)29-28(24-13-21(35-2)9-10-25(24)30)31-15-20(32-29)16-36-22-5-3-4-19(12-22)23(14-27(33)34)18-7-8-18/h3-6,9-13,15,18,23H,7-8,14,16H2,1-2H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168178
PNG
(US9688642, 40)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C(C)C(F)(F)F
Show InChI InChI=1S/C27H26F4N2O4/c1-15(27(29,30)31)25-26(22-11-19(36-2)8-9-23(22)28)32-13-18(33-25)14-37-20-5-3-4-17(10-20)21(12-24(34)35)16-6-7-16/h3-5,8-11,13,15-16,21H,6-7,12,14H2,1-2H3,(H,34,35)/t15?,21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168192
PNG
(US9688642, 41)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1COC1
Show InChI InChI=1S/C27H27FN2O6/c1-33-19-7-8-24(28)23(10-19)26-27(36-21-14-34-15-21)30-18(12-29-26)13-35-20-4-2-3-17(9-20)22(11-25(31)32)16-5-6-16/h2-4,7-10,12,16,21-22H,5-6,11,13-15H2,1H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168198
PNG
(US9688642, 44)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1NCC(C)(C)C
Show InChI InChI=1S/C29H34FN3O4/c1-29(2,3)17-32-28-27(24-13-21(36-4)10-11-25(24)30)31-15-20(33-28)16-37-22-7-5-6-19(12-22)23(14-26(34)35)18-8-9-18/h5-7,10-13,15,18,23H,8-9,14,16-17H2,1-4H3,(H,32,33)(H,34,35)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168198
PNG
(US9688642, 44)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1NCC(C)(C)C
Show InChI InChI=1S/C29H34FN3O4/c1-29(2,3)17-32-28-27(24-13-21(36-4)10-11-25(24)30)31-15-20(33-28)16-37-22-7-5-6-19(12-22)23(14-26(34)35)18-8-9-18/h5-7,10-13,15,18,23H,8-9,14,16-17H2,1-4H3,(H,32,33)(H,34,35)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168197
PNG
(US9688642, 45)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CCOCC1
Show InChI InChI=1S/C28H30FN3O5/c1-35-21-7-8-25(29)24(14-21)27-28(32-9-11-36-12-10-32)31-20(16-30-27)17-37-22-4-2-3-19(13-22)23(15-26(33)34)18-5-6-18/h2-4,7-8,13-14,16,18,23H,5-6,9-12,15,17H2,1H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168156
PNG
(US9688642, 46)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C31H33FN2O4/c1-31(2)13-5-8-26(31)30-29(25-15-22(37-3)11-12-27(25)32)33-17-21(34-30)18-38-23-7-4-6-20(14-23)24(16-28(35)36)19-9-10-19/h4,6-8,11-12,14-15,17,19,24H,5,9-10,13,16,18H2,1-3H3,(H,35,36)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168162
PNG
(US9688642, 10)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cc(C)cc(C)c1
Show InChI InChI=1S/C32H31FN2O4/c1-19-11-20(2)13-23(12-19)31-32(28-15-25(38-3)9-10-29(28)33)34-17-24(35-31)18-39-26-6-4-5-22(14-26)27(16-30(36)37)21-7-8-21/h4-6,9-15,17,21,27H,7-8,16,18H2,1-3H3,(H,36,37)/t27-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168190
PNG
(US9688642, 11)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C=C(C)C
Show InChI InChI=1S/C27H28FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,9-11,13-14,17,21H,7-8,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168167
PNG
(US9688642, 19)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCC1
Show InChI InChI=1S/C28H29FN2O5/c1-34-21-10-11-25(29)24(13-21)27-28(36-20-5-3-6-20)31-19(15-30-27)16-35-22-7-2-4-18(12-22)23(14-26(32)33)17-8-9-17/h2,4,7,10-13,15,17,20,23H,3,5-6,8-9,14,16H2,1H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168165
PNG
(US9688642, 26)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C33H39FN2O6/c1-32(2)16-25(17-33(3,4)42-32)41-31-30(27-14-23(39-5)11-12-28(27)34)35-18-22(36-31)19-40-24-8-6-7-21(13-24)26(15-29(37)38)20-9-10-20/h6-8,11-14,18,20,25-26H,9-10,15-17,19H2,1-5H3,(H,37,38)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168158
PNG
(US9688642, 28)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(C)s1
Show InChI InChI=1S/C28H26FN3O4S/c1-16-6-9-24(37-16)28-27(22-11-25(35-2)30-14-23(22)29)31-13-19(32-28)15-36-20-5-3-4-18(10-20)21(12-26(33)34)17-7-8-17/h3-6,9-11,13-14,17,21H,7-8,12,15H2,1-2H3,(H,33,34)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168185
PNG
(US9688642, 35)
Show SMILES COc1cccc(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C31H34N2O4/c1-31(2)14-6-11-27(31)30-29(22-8-5-9-24(16-22)36-3)32-18-23(33-30)19-37-25-10-4-7-21(15-25)26(17-28(34)35)20-12-13-20/h4-5,7-11,15-16,18,20,26H,6,12-14,17,19H2,1-3H3,(H,34,35)/t26-/m0/s1
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Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168176
PNG
(US9688642, 38)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N(C)C
Show InChI InChI=1S/C26H28FN3O4/c1-30(2)26-25(22-12-19(33-3)9-10-23(22)27)28-14-18(29-26)15-34-20-6-4-5-17(11-20)21(13-24(31)32)16-7-8-16/h4-6,9-12,14,16,21H,7-8,13,15H2,1-3H3,(H,31,32)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168199
PNG
(US9688642, 42)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1CC(C)(C)C1
Show InChI InChI=1S/C31H35FN2O5/c1-31(2)14-19(15-31)17-39-30-29(26-12-23(37-3)9-10-27(26)32)33-16-22(34-30)18-38-24-6-4-5-21(11-24)25(13-28(35)36)20-7-8-20/h4-6,9-12,16,19-20,25H,7-8,13-15,17-18H2,1-3H3,(H,35,36)/t25-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168155
PNG
(US9688642, 43)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(s1)C(C)(C)C
Show InChI InChI=1S/C32H33FN2O4S/c1-32(2,3)28-13-12-27(40-28)31-30(25-15-22(38-4)10-11-26(25)33)34-17-21(35-31)18-39-23-7-5-6-20(14-23)24(16-29(36)37)19-8-9-19/h5-7,10-15,17,19,24H,8-9,16,18H2,1-4H3,(H,36,37)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168197
PNG
(US9688642, 45)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CCOCC1
Show InChI InChI=1S/C28H30FN3O5/c1-35-21-7-8-25(29)24(14-21)27-28(32-9-11-36-12-10-32)31-20(16-30-27)17-37-22-4-2-3-19(13-22)23(15-26(33)34)18-5-6-18/h2-4,7-8,13-14,16,18,23H,5-6,9-12,15,17H2,1H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168156
PNG
(US9688642, 46)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C31H33FN2O4/c1-31(2)13-5-8-26(31)30-29(25-15-22(37-3)11-12-27(25)32)33-17-21(34-30)18-38-23-7-4-6-20(14-23)24(16-28(35)36)19-9-10-19/h4,6-8,11-12,14-15,17,19,24H,5,9-10,13,16,18H2,1-3H3,(H,35,36)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168196
PNG
(US9688642, 47)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)(C)C
Show InChI InChI=1S/C28H32FN3O5/c1-28(2,3)16-37-27-26(22-11-24(35-4)30-14-23(22)29)31-13-19(32-27)15-36-20-7-5-6-18(10-20)21(12-25(33)34)17-8-9-17/h5-7,10-11,13-14,17,21H,8-9,12,15-16H2,1-4H3,(H,33,34)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168169
PNG
(US9688642, 20)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cccc(C)c1
Show InChI InChI=1S/C31H29FN2O4/c1-19-5-3-7-22(13-19)30-31(27-15-24(37-2)11-12-28(27)32)33-17-23(34-30)18-38-25-8-4-6-21(14-25)26(16-29(35)36)20-9-10-20/h3-8,11-15,17,20,26H,9-10,16,18H2,1-2H3,(H,35,36)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168169
PNG
(US9688642, 20)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cccc(C)c1
Show InChI InChI=1S/C31H29FN2O4/c1-19-5-3-7-22(13-19)30-31(27-15-24(37-2)11-12-28(27)32)33-17-23(34-30)18-38-25-8-4-6-21(14-25)26(16-29(35)36)20-9-10-20/h3-8,11-15,17,20,26H,9-10,16,18H2,1-2H3,(H,35,36)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168179
PNG
(US9688642, 22)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CCCCC1
Show InChI InChI=1S/C29H32FN3O4/c1-36-22-10-11-26(30)25(15-22)28-29(33-12-3-2-4-13-33)32-21(17-31-28)18-37-23-7-5-6-20(14-23)24(16-27(34)35)19-8-9-19/h5-7,10-11,14-15,17,19,24H,2-4,8-9,12-13,16,18H2,1H3,(H,34,35)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168157
PNG
(US9688642, 27)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCCCC1
Show InChI InChI=1S/C31H35FN2O5/c1-37-24-13-14-28(32)27(16-24)30-31(39-23-8-4-2-3-5-9-23)34-22(18-33-30)19-38-25-10-6-7-21(15-25)26(17-29(35)36)20-11-12-20/h6-7,10,13-16,18,20,23,26H,2-5,8-9,11-12,17,19H2,1H3,(H,35,36)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168188
PNG
(US9688642, 29)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC(C)C
Show InChI InChI=1S/C27H29FN2O5/c1-16(2)35-27-26(23-12-20(33-3)9-10-24(23)28)29-14-19(30-27)15-34-21-6-4-5-18(11-21)22(13-25(31)32)17-7-8-17/h4-6,9-12,14,16-17,22H,7-8,13,15H2,1-3H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168184
PNG
(US9688642, 15 | US9688642, 30)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C30H32FN3O4/c1-30(2)11-5-8-24(30)29-28(23-13-26(37-3)32-16-25(23)31)33-15-20(34-29)17-38-21-7-4-6-19(12-21)22(14-27(35)36)18-9-10-18/h4,6-8,12-13,15-16,18,22H,5,9-11,14,17H2,1-3H3,(H,35,36)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168154
PNG
(US9688642, 33)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1sccc1C
Show InChI InChI=1S/C29H27FN2O4S/c1-17-10-11-37-29(17)28-27(24-13-21(35-2)8-9-25(24)30)31-15-20(32-28)16-36-22-5-3-4-19(12-22)23(14-26(33)34)18-6-7-18/h3-5,8-13,15,18,23H,6-7,14,16H2,1-2H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168181
PNG
(US9688642, 39)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1CC1
Show InChI InChI=1S/C27H27FN2O4/c1-33-20-9-10-24(28)23(12-20)27-26(17-7-8-17)30-19(14-29-27)15-34-21-4-2-3-18(11-21)22(13-25(31)32)16-5-6-16/h2-4,9-12,14,16-17,22H,5-8,13,15H2,1H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168155
PNG
(US9688642, 43)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(s1)C(C)(C)C
Show InChI InChI=1S/C32H33FN2O4S/c1-32(2,3)28-13-12-27(40-28)31-30(25-15-22(38-4)10-11-26(25)33)34-17-21(35-31)18-39-23-7-5-6-20(14-23)24(16-29(36)37)19-8-9-19/h5-7,10-15,17,19,24H,8-9,16,18H2,1-4H3,(H,36,37)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168195
PNG
(US9688642, 48)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1CC1
Show InChI InChI=1S/C27H28FN3O5/c1-34-24-10-22(23(28)13-29-24)26-27(36-14-16-5-6-16)31-19(12-30-26)15-35-20-4-2-3-18(9-20)21(11-25(32)33)17-7-8-17/h2-4,9-10,12-13,16-17,21H,5-8,11,14-15H2,1H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168152
PNG
(US9688642, 5)
Show SMILES CCC(C)c1nc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cnc1-c1cc(OC)ccc1F
Show InChI InChI=1S/C28H31FN2O4/c1-4-17(2)27-28(24-13-21(34-3)10-11-25(24)29)30-15-20(31-27)16-35-22-7-5-6-19(12-22)23(14-26(32)33)18-8-9-18/h5-7,10-13,15,17-18,23H,4,8-9,14,16H2,1-3H3,(H,32,33)/t17?,23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168152
PNG
(US9688642, 5)
Show SMILES CCC(C)c1nc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cnc1-c1cc(OC)ccc1F
Show InChI InChI=1S/C28H31FN2O4/c1-4-17(2)27-28(24-13-21(34-3)10-11-25(24)29)30-15-20(31-27)16-35-22-7-5-6-19(12-22)23(14-26(32)33)18-8-9-18/h5-7,10-13,15,17-18,23H,4,8-9,14,16H2,1-3H3,(H,32,33)/t17?,23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168166
PNG
(US9688642, 6)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CC2(CCC2)C1
Show InChI InChI=1S/C30H32FN3O4/c1-37-22-8-9-26(31)25(13-22)28-29(34-17-30(18-34)10-3-11-30)33-21(15-32-28)16-38-23-5-2-4-20(12-23)24(14-27(35)36)19-6-7-19/h2,4-5,8-9,12-13,15,19,24H,3,6-7,10-11,14,16-18H2,1H3,(H,35,36)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168166
PNG
(US9688642, 6)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CC2(CCC2)C1
Show InChI InChI=1S/C30H32FN3O4/c1-37-22-8-9-26(31)25(13-22)28-29(34-17-30(18-34)10-3-11-30)33-21(15-32-28)16-38-23-5-2-4-20(12-23)24(14-27(35)36)19-6-7-19/h2,4-5,8-9,12-13,15,19,24H,3,6-7,10-11,14,16-18H2,1H3,(H,35,36)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168174
PNG
(US9688642, 7)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCCC1
Show InChI InChI=1S/C30H33FN2O5/c1-36-23-12-13-27(31)26(15-23)29-30(38-22-7-3-2-4-8-22)33-21(17-32-29)18-37-24-9-5-6-20(14-24)25(16-28(34)35)19-10-11-19/h5-6,9,12-15,17,19,22,25H,2-4,7-8,10-11,16,18H2,1H3,(H,34,35)/t25-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168193
PNG
(US9688642, 9)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCCC1
Show InChI InChI=1S/C29H32FN3O5/c1-36-26-13-24(25(30)16-31-26)28-29(38-21-7-3-2-4-8-21)33-20(15-32-28)17-37-22-9-5-6-19(12-22)23(14-27(34)35)18-10-11-18/h5-6,9,12-13,15-16,18,21,23H,2-4,7-8,10-11,14,17H2,1H3,(H,34,35)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168175
PNG
(US9688642, 13)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCC1
Show InChI InChI=1S/C29H31FN2O5/c1-35-22-11-12-26(30)25(14-22)28-29(37-21-6-2-3-7-21)32-20(16-31-28)17-36-23-8-4-5-19(13-23)24(15-27(33)34)18-9-10-18/h4-5,8,11-14,16,18,21,24H,2-3,6-7,9-10,15,17H2,1H3,(H,33,34)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168182
PNG
(US9688642, 14)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)C
Show InChI InChI=1S/C28H31FN2O5/c1-17(2)15-36-28-27(24-12-21(34-3)9-10-25(24)29)30-14-20(31-28)16-35-22-6-4-5-19(11-22)23(13-26(32)33)18-7-8-18/h4-6,9-12,14,17-18,23H,7-8,13,15-16H2,1-3H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168164
PNG
(US9688642, 17)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1C(C)(C)C1(C)C
Show InChI InChI=1S/C32H37FN2O5/c1-31(2)27(32(31,3)4)18-40-30-29(25-14-22(38-5)11-12-26(25)33)34-16-21(35-30)17-39-23-8-6-7-20(13-23)24(15-28(36)37)19-9-10-19/h6-8,11-14,16,19,24,27H,9-10,15,17-18H2,1-5H3,(H,36,37)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168179
PNG
(US9688642, 22)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CCCCC1
Show InChI InChI=1S/C29H32FN3O4/c1-36-22-10-11-26(30)25(15-22)28-29(33-12-3-2-4-13-33)32-21(17-31-28)18-37-23-7-5-6-20(14-23)24(16-27(34)35)19-8-9-19/h5-7,10-11,14-15,17,19,24H,2-4,8-9,12-13,16,18H2,1H3,(H,34,35)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168158
PNG
(US9688642, 28)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(C)s1
Show InChI InChI=1S/C28H26FN3O4S/c1-16-6-9-24(37-16)28-27(22-11-25(35-2)30-14-23(22)29)31-13-19(32-28)15-36-20-5-3-4-18(10-20)21(12-26(33)34)17-7-8-17/h3-6,9-11,13-14,17,21H,7-8,12,15H2,1-2H3,(H,33,34)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168183
PNG
(US9688642, 31)
Show SMILES COc1cc(ccn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C30H33N3O4/c1-30(2)12-5-8-25(30)29-28(21-11-13-31-26(15-21)36-3)32-17-22(33-29)18-37-23-7-4-6-20(14-23)24(16-27(34)35)19-9-10-19/h4,6-8,11,13-15,17,19,24H,5,9-10,12,16,18H2,1-3H3,(H,34,35)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168183
PNG
(US9688642, 31)
Show SMILES COc1cc(ccn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C30H33N3O4/c1-30(2)12-5-8-25(30)29-28(21-11-13-31-26(15-21)36-3)32-17-22(33-29)18-37-23-7-4-6-20(14-23)24(16-27(34)35)19-9-10-19/h4,6-8,11,13-15,17,19,24H,5,9-10,12,16,18H2,1-3H3,(H,34,35)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168180
PNG
(US9688642, 34)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N(C)C(C)C
Show InChI InChI=1S/C28H32FN3O4/c1-17(2)32(3)28-27(24-13-21(35-4)10-11-25(24)29)30-15-20(31-28)16-36-22-7-5-6-19(12-22)23(14-26(33)34)18-8-9-18/h5-7,10-13,15,17-18,23H,8-9,14,16H2,1-4H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168180
PNG
(US9688642, 34)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N(C)C(C)C
Show InChI InChI=1S/C28H32FN3O4/c1-17(2)32(3)28-27(24-13-21(35-4)10-11-25(24)29)30-15-20(31-28)16-36-22-7-5-6-19(12-22)23(14-26(33)34)18-8-9-18/h5-7,10-13,15,17-18,23H,8-9,14,16H2,1-4H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168181
PNG
(US9688642, 39)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1CC1
Show InChI InChI=1S/C27H27FN2O4/c1-33-20-9-10-24(28)23(12-20)27-26(17-7-8-17)30-19(14-29-27)15-34-21-4-2-3-18(11-21)22(13-25(31)32)16-5-6-16/h2-4,9-12,14,16-17,22H,5-8,13,15H2,1H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168199
PNG
(US9688642, 42)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1CC(C)(C)C1
Show InChI InChI=1S/C31H35FN2O5/c1-31(2)14-19(15-31)17-39-30-29(26-12-23(37-3)9-10-27(26)32)33-16-22(34-30)18-38-24-6-4-5-21(11-24)25(13-28(35)36)20-7-8-20/h4-6,9-12,16,19-20,25H,7-8,13-15,17-18H2,1-3H3,(H,35,36)/t25-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168196
PNG
(US9688642, 47)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)(C)C
Show InChI InChI=1S/C28H32FN3O5/c1-28(2,3)16-37-27-26(22-11-24(35-4)30-14-23(22)29)31-13-19(32-27)15-36-20-7-5-6-18(10-20)21(12-25(33)34)17-8-9-17/h5-7,10-11,13-14,17,21H,8-9,12,15-16H2,1-4H3,(H,33,34)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168171
PNG
(US9688642, 1)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)(C)C
Show InChI InChI=1S/C29H33FN2O4/c1-29(2,3)15-26-28(24-13-21(35-4)10-11-25(24)30)31-16-20(32-26)17-36-22-7-5-6-19(12-22)23(14-27(33)34)18-8-9-18/h5-7,10-13,16,18,23H,8-9,14-15,17H2,1-4H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168191
PNG
(US9688642, 2)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C
Show InChI InChI=1S/C27H30FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,10-11,13-14,16-17,21H,7-9,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168175
PNG
(US9688642, 13)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCC1
Show InChI InChI=1S/C29H31FN2O5/c1-35-22-11-12-26(30)25(14-22)28-29(37-21-6-2-3-7-21)32-20(16-31-28)17-36-23-8-4-5-19(13-23)24(15-27(33)34)18-9-10-18/h4-5,8,11-14,16,18,21,24H,2-3,6-7,9-10,15,17H2,1H3,(H,33,34)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168164
PNG
(US9688642, 17)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1C(C)(C)C1(C)C
Show InChI InChI=1S/C32H37FN2O5/c1-31(2)27(32(31,3)4)18-40-30-29(25-14-22(38-5)11-12-26(25)33)34-16-21(35-30)17-39-23-8-6-7-20(13-23)24(15-28(36)37)19-9-10-19/h6-8,11-14,16,19,24,27H,9-10,15,17-18H2,1-5H3,(H,36,37)/t24-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168161
PNG
(US9688642, 24)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CC(C)(C)CC(C)(C)C1
Show InChI InChI=1S/C34H41FN2O5/c1-33(2)16-26(17-34(3,4)20-33)42-32-31(28-14-24(40-5)11-12-29(28)35)36-18-23(37-32)19-41-25-8-6-7-22(13-25)27(15-30(38)39)21-9-10-21/h6-8,11-14,18,21,26-27H,9-10,15-17,19-20H2,1-5H3,(H,38,39)/t27-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168161
PNG
(US9688642, 24)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CC(C)(C)CC(C)(C)C1
Show InChI InChI=1S/C34H41FN2O5/c1-33(2)16-26(17-34(3,4)20-33)42-32-31(28-14-24(40-5)11-12-29(28)35)36-18-23(37-32)19-41-25-8-6-7-22(13-25)27(15-30(38)39)21-9-10-21/h6-8,11-14,18,21,26-27H,9-10,15-17,19-20H2,1-5H3,(H,38,39)/t27-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168160
PNG
(US9688642, 25)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C33H33FN2O4/c1-20(2)21-7-11-23(12-8-21)32-33(29-16-26(39-3)13-14-30(29)34)35-18-25(36-32)19-40-27-6-4-5-24(15-27)28(17-31(37)38)22-9-10-22/h4-8,11-16,18,20,22,28H,9-10,17,19H2,1-3H3,(H,37,38)/t28-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


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More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168163
PNG
(US9688642, 32)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCCC(F)(F)F
Show InChI InChI=1S/C27H26F4N2O5/c1-36-19-7-8-23(28)22(12-19)25-26(37-10-9-27(29,30)31)33-18(14-32-25)15-38-20-4-2-3-17(11-20)21(13-24(34)35)16-5-6-16/h2-4,7-8,11-12,14,16,21H,5-6,9-10,13,15H2,1H3,(H,34,35)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168189
PNG
(US9688642, 36)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(C)s1
Show InChI InChI=1S/C29H27FN2O4S/c1-17-6-11-26(37-17)29-28(24-13-21(35-2)9-10-25(24)30)31-15-20(32-29)16-36-22-5-3-4-19(12-22)23(14-27(33)34)18-7-8-18/h3-6,9-13,15,18,23H,7-8,14,16H2,1-2H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168174
PNG
(US9688642, 7)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCCC1
Show InChI InChI=1S/C30H33FN2O5/c1-36-23-12-13-27(31)26(15-23)29-30(38-22-7-3-2-4-8-22)33-21(17-32-29)18-37-24-9-5-6-20(14-24)25(16-28(34)35)19-10-11-19/h5-6,9,12-15,17,19,22,25H,2-4,7-8,10-11,16,18H2,1H3,(H,34,35)/t25-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168177
PNG
(US9688642, 8)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C=C(C)C
Show InChI InChI=1S/C28H29FN2O4/c1-17(2)11-26-28(24-13-21(34-3)9-10-25(24)29)30-15-20(31-26)16-35-22-6-4-5-19(12-22)23(14-27(32)33)18-7-8-18/h4-6,9-13,15,18,23H,7-8,14,16H2,1-3H3,(H,32,33)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168184
PNG
(US9688642, 15 | US9688642, 30)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C30H32FN3O4/c1-30(2)11-5-8-24(30)29-28(23-13-26(37-3)32-16-25(23)31)33-15-20(34-29)17-38-21-7-4-6-19(12-21)22(14-27(35)36)18-9-10-18/h4,6-8,12-13,15-16,18,22H,5,9-11,14,17H2,1-3H3,(H,35,36)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168194
PNG
(US9688642, 16)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CCCC1
Show InChI InChI=1S/C28H30FN3O5/c1-35-25-12-23(24(29)15-30-25)27-28(37-20-6-2-3-7-20)32-19(14-31-27)16-36-21-8-4-5-18(11-21)22(13-26(33)34)17-9-10-17/h4-5,8,11-12,14-15,17,20,22H,2-3,6-7,9-10,13,16H2,1H3,(H,33,34)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168168
PNG
(US9688642, 18)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccccc1
Show InChI InChI=1S/C30H27FN2O4/c1-36-23-12-13-27(31)26(15-23)30-29(20-6-3-2-4-7-20)33-22(17-32-30)18-37-24-9-5-8-21(14-24)25(16-28(34)35)19-10-11-19/h2-9,12-15,17,19,25H,10-11,16,18H2,1H3,(H,34,35)/t25-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168160
PNG
(US9688642, 25)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C33H33FN2O4/c1-20(2)21-7-11-23(12-8-21)32-33(29-16-26(39-3)13-14-30(29)34)35-18-25(36-32)19-40-27-6-4-5-24(15-27)28(17-31(37)38)22-9-10-22/h4-8,11-16,18,20,22,28H,9-10,17,19H2,1-3H3,(H,37,38)/t28-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168165
PNG
(US9688642, 26)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C33H39FN2O6/c1-32(2)16-25(17-33(3,4)42-32)41-31-30(27-14-23(39-5)11-12-28(27)34)35-18-22(36-31)19-40-24-8-6-7-21(13-24)26(15-29(37)38)20-9-10-20/h6-8,11-14,18,20,25-26H,9-10,15-17,19H2,1-5H3,(H,37,38)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168154
PNG
(US9688642, 33)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1sccc1C
Show InChI InChI=1S/C29H27FN2O4S/c1-17-10-11-37-29(17)28-27(24-13-21(35-2)8-9-25(24)30)31-15-20(32-28)16-36-22-5-3-4-19(12-22)23(14-26(33)34)18-6-7-18/h3-5,8-13,15,18,23H,6-7,14,16H2,1-2H3,(H,33,34)/t23-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168185
PNG
(US9688642, 35)
Show SMILES COc1cccc(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C
Show InChI InChI=1S/C31H34N2O4/c1-31(2)14-6-11-27(31)30-29(22-8-5-9-24(16-22)36-3)32-18-23(33-30)19-37-25-10-4-7-21(15-25)26(17-28(34)35)20-12-13-20/h4-5,7-11,15-16,18,20,26H,6,12-14,17,19H2,1-3H3,(H,34,35)/t26-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168178
PNG
(US9688642, 40)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C(C)C(F)(F)F
Show InChI InChI=1S/C27H26F4N2O4/c1-15(27(29,30)31)25-26(22-11-19(36-2)8-9-23(22)28)32-13-18(33-25)14-37-20-5-3-4-17(10-20)21(12-24(34)35)16-6-7-16/h3-5,8-11,13,15-16,21H,6-7,12,14H2,1-2H3,(H,34,35)/t15?,21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM168192
PNG
(US9688642, 41)
Show SMILES COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OC1COC1
Show InChI InChI=1S/C27H27FN2O6/c1-33-19-7-8-24(28)23(10-19)26-27(36-21-14-34-15-21)30-18(12-29-26)13-35-20-4-2-3-17(9-20)22(11-25(31)32)16-5-6-16/h2-4,7-10,12,16,21-22H,5-6,11,13-15H2,1H3,(H,31,32)/t22-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
BDBM168195
PNG
(US9688642, 48)
Show SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC1CC1
Show InChI InChI=1S/C27H28FN3O5/c1-34-24-10-22(23(28)13-29-24)26-27(36-14-16-5-6-16)31-19(12-30-26)15-35-20-4-2-3-18(9-20)21(11-25(32)33)17-7-8-17/h2-4,9-10,12-13,16-17,21H,5-8,11,14-15H2,1H3,(H,32,33)/t21-/m0/s1
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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%