BindingDB logo
myBDB logout

Patent code US9688645

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173886
PNG
(US9688645, 1-1)
Show SMILES CC(C)[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C25H40N4O6/c1-17(2)22-16-34-13-5-6-14-35-19-10-8-18(9-11-19)15-21(23(30)27-22)29-25(33)28-20(24(31)32)7-3-4-12-26/h8-11,17,20-22H,3-7,12-16,26H2,1-2H3,(H,27,30)(H,31,32)(H2,28,29,33)/t20-,21+,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173906
PNG
(US9688645, 3-1)
Show SMILES CC(C)[C@H]1COC\C=C\COc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C25H38N4O6/c1-17(2)22-16-34-13-5-6-14-35-19-10-8-18(9-11-19)15-21(23(30)27-22)29-25(33)28-20(24(31)32)7-3-4-12-26/h5-6,8-11,17,20-22H,3-4,7,12-16,26H2,1-2H3,(H,27,30)(H,31,32)(H2,28,29,33)/b6-5+/t20-,21+,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173904
PNG
(US9688645, 2-1)
Show SMILES CC(C)[C@H]1COCCCCCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C29H48N4O6/c1-21(2)26-20-38-17-9-5-3-4-6-10-18-39-23-14-12-22(13-15-23)19-25(27(34)31-26)33-29(37)32-24(28(35)36)11-7-8-16-30/h12-15,21,24-26H,3-11,16-20,30H2,1-2H3,(H,31,34)(H,35,36)(H2,32,33,37)/t24-,25+,26+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.80n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173918
PNG
(US9688645, 5-2)
Show SMILES CC(C)[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](Cc3ccc(N)nc3)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C27H37N5O6/c1-17(2)23-16-37-11-3-4-12-38-20-8-5-18(6-9-20)13-21(25(33)30-23)31-27(36)32-22(26(34)35)14-19-7-10-24(28)29-15-19/h5-10,15,17,21-23H,3-4,11-14,16H2,1-2H3,(H2,28,29)(H,30,33)(H,34,35)(H2,31,32,36)/t21-,22+,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173923
PNG
(US9688645, 6-3)
Show SMILES CC(C)[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](Cc3ccc(N)nc3)C(O)=O)C(=O)N1)cc2F
Show InChI InChI=1S/C27H36FN5O6/c1-16(2)22-15-38-9-3-4-10-39-23-7-5-17(11-19(23)28)12-20(25(34)31-22)32-27(37)33-21(26(35)36)13-18-6-8-24(29)30-14-18/h5-8,11,14,16,20-22H,3-4,9-10,12-13,15H2,1-2H3,(H2,29,30)(H,31,34)(H,35,36)(H2,32,33,37)/t20-,21+,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173908
PNG
(US9688645, 4-1)
Show SMILES NCCCCC(NC(=O)N[C@@H]1CCCCCCCCOCCNC1=O)C(O)=O
Show InChI InChI=1S/C19H36N4O5/c20-11-7-6-10-16(18(25)26)23-19(27)22-15-9-5-3-1-2-4-8-13-28-14-12-21-17(15)24/h15-16H,1-14,20H2,(H,21,24)(H,25,26)(H2,22,23,27)/t15-,16?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173903
PNG
(US9688645, 1-9)
Show SMILES CC(C)(C)[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C26H42N4O6/c1-26(2,3)22-17-35-14-6-7-15-36-19-11-9-18(10-12-19)16-21(23(31)30-22)29-25(34)28-20(24(32)33)8-4-5-13-27/h9-12,20-22H,4-8,13-17,27H2,1-3H3,(H,30,31)(H,32,33)(H2,28,29,34)/t20-,21+,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173922
PNG
(US9688645, 6-2)
Show SMILES CC(C)[C@H]1COCCCCc2ccc(C[C@@H](NC(=O)N[C@@H](Cc3ccc(N)nc3)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C27H37N5O5/c1-17(2)23-16-37-12-4-3-5-18-6-8-19(9-7-18)13-21(25(33)30-23)31-27(36)32-22(26(34)35)14-20-10-11-24(28)29-15-20/h6-11,15,17,21-23H,3-5,12-14,16H2,1-2H3,(H2,28,29)(H,30,33)(H,34,35)(H2,31,32,36)/t21-,22+,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173926
PNG
(US9688645, 7-1)
Show SMILES CC(C)[C@H]1COCCC(=O)Nc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C24H37N5O6/c1-15(2)20-14-35-12-10-21(30)26-17-8-6-16(7-9-17)13-19(22(31)27-20)29-24(34)28-18(23(32)33)5-3-4-11-25/h6-9,15,18-20H,3-5,10-14,25H2,1-2H3,(H,26,30)(H,27,31)(H,32,33)(H2,28,29,34)/t18-,19+,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173929
PNG
(US9688645, 8-1)
Show SMILES CC(C)[C@H]1COCC(O)C(O)COc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C25H40N4O8/c1-15(2)20-12-36-13-21(30)22(31)14-37-17-8-6-16(7-9-17)11-19(23(32)27-20)29-25(35)28-18(24(33)34)5-3-4-10-26/h6-9,15,18-22,30-31H,3-5,10-14,26H2,1-2H3,(H,27,32)(H,33,34)(H2,28,29,35)/t18-,19+,20+,21?,22?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173902
PNG
(US9688645, 1-8)
Show SMILES C[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C23H36N4O6/c1-16-15-32-12-4-5-13-33-18-9-7-17(8-10-18)14-20(21(28)25-16)27-23(31)26-19(22(29)30)6-2-3-11-24/h7-10,16,19-20H,2-6,11-15,24H2,1H3,(H,25,28)(H,29,30)(H2,26,27,31)/t16-,19-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173920
PNG
(US9688645, 5-3)
Show SMILES Nc1ccc(C[C@H](NC(=O)N[C@@H]2Cc3ccc(OCCCCOC[C@@H](NC2=O)C2CC2)cc3)C(O)=O)cn1
Show InChI InChI=1S/C27H35N5O6/c28-24-10-5-18(15-29-24)14-22(26(34)35)32-27(36)31-21-13-17-3-8-20(9-4-17)38-12-2-1-11-37-16-23(19-6-7-19)30-25(21)33/h3-5,8-10,15,19,21-23H,1-2,6-7,11-14,16H2,(H2,28,29)(H,30,33)(H,34,35)(H2,31,32,36)/t21-,22+,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173930
PNG
(US9688645, 8-2)
Show SMILES CC(C)[C@H]1COCC(O)CCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C25H40N4O7/c1-16(2)22-15-35-14-18(30)10-12-36-19-8-6-17(7-9-19)13-21(23(31)27-22)29-25(34)28-20(24(32)33)5-3-4-11-26/h6-9,16,18,20-22,30H,3-5,10-15,26H2,1-2H3,(H,27,31)(H,32,33)(H2,28,29,34)/t18?,20-,21+,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173928
PNG
(US9688645, 7-4)
Show SMILES CC(C)[C@H]1COCCNC(=O)c2ccc(C[C@@H](NC(=O)N[C@@H](Cc3ccc(N)nc3)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C26H34N6O6/c1-15(2)21-14-38-10-9-28-23(33)18-6-3-16(4-7-18)11-19(24(34)30-21)31-26(37)32-20(25(35)36)12-17-5-8-22(27)29-13-17/h3-8,13,15,19-21H,9-12,14H2,1-2H3,(H2,27,29)(H,28,33)(H,30,34)(H,35,36)(H2,31,32,37)/t19-,20+,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173900
PNG
(US9688645, 1-7)
Show SMILES CCC[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C25H40N4O6/c1-2-7-19-17-34-14-5-6-15-35-20-11-9-18(10-12-20)16-22(23(30)27-19)29-25(33)28-21(24(31)32)8-3-4-13-26/h9-12,19,21-22H,2-8,13-17,26H2,1H3,(H,27,30)(H,31,32)(H2,28,29,33)/t19-,21-,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 49n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173921
PNG
(US9688645, 6-1)
Show SMILES CC(C)[C@H]1COCCCCC2=CC(C[C@@H](NC(=O)N[C@@H](Cc3ccc(N)nc3)C(O)=O)C(=O)N1)=CC2
Show InChI InChI=1S/C26H37N5O5/c1-16(2)22-15-36-10-4-3-5-17-6-7-18(11-17)12-20(24(32)29-22)30-26(35)31-21(25(33)34)13-19-8-9-23(27)28-14-19/h7-9,11,14,16,20-22H,3-6,10,12-13,15H2,1-2H3,(H2,27,28)(H,29,32)(H,33,34)(H2,30,31,35)/t20-,21+,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173932
PNG
(US9688645, 6-6)
Show SMILES CC(C)[C@H]1COCCCCOC[C@@H](NC(=O)N[C@H](CCCCN)C(O)=O)C(=O)N1
Show InChI InChI=1S/C19H36N4O6/c1-13(2)15-11-28-9-5-6-10-29-12-16(17(24)21-15)23-19(27)22-14(18(25)26)7-3-4-8-20/h13-16H,3-12,20H2,1-2H3,(H,21,24)(H,25,26)(H2,22,23,27)/t14-,15-,16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 53n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173924
PNG
(US9688645, 6-4)
Show SMILES CC(C)[C@H]1COCCCCOC[C@@H](NC(=O)N[C@H](Cc2ccc(N)nc2)C(O)=O)C(=O)N1
Show InChI InChI=1S/C21H33N5O6/c1-13(2)16-11-31-7-3-4-8-32-12-17(19(27)24-16)26-21(30)25-15(20(28)29)9-14-5-6-18(22)23-10-14/h5-6,10,13,15-17H,3-4,7-9,11-12H2,1-2H3,(H2,22,23)(H,24,27)(H,28,29)(H2,25,26,30)/t15-,16-,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173931
PNG
(US9688645, 8-3)
Show SMILES CC(C)[C@H]1COCCCCOc2ccc(C[C@@H](NS(=O)(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C24H40N4O7S/c1-17(2)22-16-34-13-5-6-14-35-19-10-8-18(9-11-19)15-21(23(29)26-22)28-36(32,33)27-20(24(30)31)7-3-4-12-25/h8-11,17,20-22,27-28H,3-7,12-16,25H2,1-2H3,(H,26,29)(H,30,31)/t20-,21+,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 59n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173897
PNG
(US9688645, 1-4)
Show SMILES NCCCC[C@H](NC(=O)N[C@@H]1Cc2ccc(OCCCCOC[C@@H](NC1=O)c1ccccc1)cc2)C(O)=O
Show InChI InChI=1S/C28H38N4O6/c29-15-5-4-10-23(27(34)35)31-28(36)32-24-18-20-11-13-22(14-12-20)38-17-7-6-16-37-19-25(30-26(24)33)21-8-2-1-3-9-21/h1-3,8-9,11-14,23-25H,4-7,10,15-19,29H2,(H,30,33)(H,34,35)(H2,31,32,36)/t23-,24+,25+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173898
PNG
(US9688645, 1-5)
Show SMILES NCCCC[C@H](NC(=O)N[C@@H]1Cc2ccc(OCCCCOC[C@H](Cc3ccccc3)NC1=O)cc2)C(O)=O
Show InChI InChI=1S/C29H40N4O6/c30-15-5-4-10-25(28(35)36)32-29(37)33-26-19-22-11-13-24(14-12-22)39-17-7-6-16-38-20-23(31-27(26)34)18-21-8-2-1-3-9-21/h1-3,8-9,11-14,23,25-26H,4-7,10,15-20,30H2,(H,31,34)(H,35,36)(H2,32,33,37)/t23-,25-,26+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 105n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173894
PNG
(US9688645, 1-3)
Show SMILES CC1(C)COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C24H38N4O6/c1-24(2)16-33-13-5-6-14-34-18-10-8-17(9-11-18)15-20(21(29)28-24)27-23(32)26-19(22(30)31)7-3-4-12-25/h8-11,19-20H,3-7,12-16,25H2,1-2H3,(H,28,29)(H,30,31)(H2,26,27,32)/t19-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 269n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173911
PNG
(US9688645, 5-1)
Show SMILES CC(C)[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](CS(=O)(=O)CCN)C(O)=O)C(=O)N1)cc2
Show InChI InChI=1S/C24H38N4O8S/c1-16(2)20-14-35-10-3-4-11-36-18-7-5-17(6-8-18)13-19(22(29)26-20)27-24(32)28-21(23(30)31)15-37(33,34)12-9-25/h5-8,16,19-21H,3-4,9-15,25H2,1-2H3,(H,26,29)(H,30,31)(H2,27,28,32)/t19-,20-,21+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 649n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173899
PNG
(US9688645, 1-6)
Show SMILES NCCCC[C@H](NC(=O)N[C@@H]1Cc2ccc(OCCCCOC[C@@H](NC1=O)C1CCCCC1)cc2)C(O)=O
Show InChI InChI=1S/C28H44N4O6/c29-15-5-4-10-23(27(34)35)31-28(36)32-24-18-20-11-13-22(14-12-20)38-17-7-6-16-37-19-25(30-26(24)33)21-8-2-1-3-9-21/h11-14,21,23-25H,1-10,15-19,29H2,(H,30,33)(H,34,35)(H2,31,32,36)/t23-,24+,25+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 811n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)


(Homo sapiens (Human))
BDBM173893
PNG
(US9688645, 1-2)
Show SMILES NCCCC[C@H](NC(=O)N[C@@H]1Cc2ccc(OCCCCOCCNC1=O)cc2)C(O)=O
Show InChI InChI=1S/C22H34N4O6/c23-10-2-1-5-18(21(28)29)25-22(30)26-19-15-16-6-8-17(9-7-16)32-13-4-3-12-31-14-11-24-20(19)27/h6-9,18-19H,1-5,10-15,23H2,(H,24,27)(H,28,29)(H2,25,26,30)/t18-,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.04E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%