BindingDB logo
myBDB logout

Patent code US9688668

Compile Data Set for Download or QSAR
Found 150 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174126
PNG
(US9688668, 1a)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)C(=O)N1CCCC1C(N)=N
Show InChI InChI=1S/C24H39N3O/c1-2-3-4-5-6-7-8-9-10-11-13-20-15-17-21(18-16-20)24(28)27-19-12-14-22(27)23(25)26/h15-18,22H,2-14,19H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
100n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174114
PNG
(US9688668, 64)
Show SMILES NC(=N)N1CCCC1.CCCCCCCCc1ccc(cc1)-c1noc(CC)n1
Show InChI InChI=1S/C18H26N2O.C5H11N3/c1-3-5-6-7-8-9-10-15-11-13-16(14-12-15)18-19-17(4-2)21-20-18;6-5(7)8-3-1-2-4-8/h11-14H,3-10H2,1-2H3;1-4H2,(H3,6,7)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174049
PNG
(US9688668, 16)
Show SMILES CCCCCCCCCCCCc1cccc(c1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-2-3-4-5-6-7-8-9-10-11-13-19-14-12-15-20(18-19)21-27-23(29-28-21)24(16-17-24)22(25)26/h12,14-15,18H,2-11,13,16-17H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174047
PNG
(US9688668, 15)
Show SMILES CCCCCCCCCCCc1cc(ccc1C)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-3-4-5-6-7-8-9-10-11-12-19-17-20(14-13-18(19)2)21-27-23(29-28-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174046
PNG
(US9688668, 14)
Show SMILES CCCCCCCCCCCc1cc(ccc1CO)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-16-19(12-13-20(18)17-29)21-27-23(30-28-21)24(14-15-24)22(25)26/h12-13,16,29H,2-11,14-15,17H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174055
PNG
(US9688668, 22)
Show SMILES CCCCCCCCCCCc1cc(-c2nnc(o2)C2(CC2)C(N)=N)c(OC)cc1OC
Show InChI InChI=1S/C25H38N4O3/c1-4-5-6-7-8-9-10-11-12-13-18-16-19(21(31-3)17-20(18)30-2)22-28-29-24(32-22)25(14-15-25)23(26)27/h16-17H,4-15H2,1-3H3,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174065
PNG
(US9688668, 29)
Show SMILES CCCCCCCCCCCc1cc(ccc1F)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H33FN4O/c1-2-3-4-5-6-7-8-9-10-11-17-16-18(12-13-19(17)24)20-27-28-22(29-20)23(14-15-23)21(25)26/h12-13,16H,2-11,14-15H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174060
PNG
(US9688668, 25)
Show SMILES CCCCCCCCCCCc1ccc(F)c(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H33FN4O/c1-2-3-4-5-6-7-8-9-10-11-17-12-13-19(24)18(16-17)20-27-28-22(29-20)23(14-15-23)21(25)26/h12-13,16H,2-11,14-15H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174044
PNG
(US9688668, 13)
Show SMILES NC(=N)C1(CC1)c1nc(no1)-c1cccc(CCc2cccc(CCC3CCCCC3)c2)c1
Show InChI InChI=1S/C28H34N4O/c29-26(30)28(16-17-28)27-31-25(32-33-27)24-11-5-10-23(19-24)15-14-22-9-4-8-21(18-22)13-12-20-6-2-1-3-7-20/h4-5,8-11,18-20H,1-3,6-7,12-17H2,(H3,29,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174066
PNG
(US9688668, 30)
Show SMILES CCCCCCCCCCCCc1cccc(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-2-3-4-5-6-7-8-9-10-11-13-19-14-12-15-20(18-19)21-27-28-23(29-21)24(16-17-24)22(25)26/h12,14-15,18H,2-11,13,16-17H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174061
PNG
(US9688668, 26)
Show SMILES CCCCCCCCCCCc1cccc(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H34N4O/c1-2-3-4-5-6-7-8-9-10-12-18-13-11-14-19(17-18)20-26-27-22(28-20)23(15-16-23)21(24)25/h11,13-14,17H,2-10,12,15-16H2,1H3,(H3,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174063
PNG
(US9688668, 27)
Show SMILES CCCCCCCCCCCc1cc(ccc1OC)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O2/c1-3-4-5-6-7-8-9-10-11-12-18-17-19(13-14-20(18)29-2)21-27-28-23(30-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174067
PNG
(US9688668, 31)
Show SMILES NC(=N)C1(CC1)c1nnc(o1)-c1cccc(CCCCCCOCC2CCCCC2)c1
Show InChI InChI=1S/C25H36N4O2/c26-23(27)25(14-15-25)24-29-28-22(31-24)21-13-8-12-19(17-21)9-4-1-2-7-16-30-18-20-10-5-3-6-11-20/h8,12-13,17,20H,1-7,9-11,14-16,18H2,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174053
PNG
(US9688668, 20)
Show SMILES CCCCCCCCCCCCc1cccc(c1)-c1coc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C25H37N3O/c1-2-3-4-5-6-7-8-9-10-11-13-20-14-12-15-21(18-20)22-19-29-24(28-22)25(16-17-25)23(26)27/h12,14-15,18-19H,2-11,13,16-17H2,1H3,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174056
PNG
(US9688668, 23)
Show SMILES CCCCCCCCCCCc1ccc(C)c(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-3-4-5-6-7-8-9-10-11-12-19-14-13-18(2)20(17-19)21-27-28-23(29-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174054
PNG
(US9688668, 21)
Show SMILES CCCCCCCCCCCc1cccc(c1)-c1nc(n[nH]1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H35N5/c1-2-3-4-5-6-7-8-9-10-12-18-13-11-14-19(17-18)20-26-22(28-27-20)23(15-16-23)21(24)25/h11,13-14,17H,2-10,12,15-16H2,1H3,(H3,24,25)(H,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174059
PNG
(US9688668, 24)
Show SMILES CCCCCCCCCCCc1ccc(OC)c(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O2/c1-3-4-5-6-7-8-9-10-11-12-18-13-14-20(29-2)19(17-18)21-27-28-23(30-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174064
PNG
(US9688668, 28)
Show SMILES CCCCCCCCCCCc1cc(ccc1C)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-3-4-5-6-7-8-9-10-11-12-19-17-20(14-13-18(19)2)21-27-28-23(29-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174068
PNG
(US9688668, 32)
Show SMILES NC(=N)C1(CC1)c1nnc(o1)-c1ccc(CCCCCCCOCC2CCCCC2)cc1
Show InChI InChI=1S/C26H38N4O2/c27-24(28)26(16-17-26)25-30-29-23(32-25)22-14-12-20(13-15-22)9-5-2-1-3-8-18-31-19-21-10-6-4-7-11-21/h12-15,21H,1-11,16-19H2,(H3,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174050
PNG
(US9688668, 17)
Show SMILES NC(=N)C1(CC1)c1nc(no1)-c1cccc(CCCCCCOCC2CCCCC2)c1
Show InChI InChI=1S/C25H36N4O2/c26-23(27)25(14-15-25)24-28-22(29-31-24)21-13-8-12-19(17-21)9-4-1-2-7-16-30-18-20-10-5-3-6-11-20/h8,12-13,17,20H,1-7,9-11,14-16,18H2,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM50443388
PNG
(CHEMBL3086782 | US9688668, SLR080811)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.30E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174126
PNG
(US9688668, 1a)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)C(=O)N1CCCC1C(N)=N
Show InChI InChI=1S/C24H39N3O/c1-2-3-4-5-6-7-8-9-10-11-13-20-15-17-21(18-16-20)24(28)27-19-12-14-22(27)23(25)26/h15-18,22H,2-14,19H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.50E+3n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM50139650
PNG
(CHEMBL3546834 | US9688668, 50)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174108
PNG
(US9688668, 60)
Show SMILES NC(=N)N1CC[C@H]1C1CCC(C1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H25N3/c22-21(23)24-13-12-20(24)19-11-10-18(14-19)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-9,18-20H,10-14H2,(H3,22,23)/t18?,19?,20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174119
PNG
(US9688668, 68)
Show SMILES NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(CS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H21N5O3S/c21-20(22)25-12-4-7-17(25)19-23-18(24-28-19)15-10-8-14(9-11-15)13-29(26,27)16-5-2-1-3-6-16/h1-3,5-6,8-11,17H,4,7,12-13H2,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174123
PNG
(US9688668, 76)
Show SMILES CCCCCCCCCCCCc1noc(C[C@@H]2CCCN2C(N)=N)n1
Show InChI InChI=1S/C20H37N5O/c1-2-3-4-5-6-7-8-9-10-11-14-18-23-19(26-24-18)16-17-13-12-15-25(17)20(21)22/h17H,2-16H2,1H3,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174026
PNG
(US9688668, 6)
Show SMILES CCCCCCCCCCc1ccc(\C=C\CC(N)=N)cc1
Show InChI InChI=1S/C20H32N2/c1-2-3-4-5-6-7-8-9-11-18-14-16-19(17-15-18)12-10-13-20(21)22/h10,12,14-17H,2-9,11,13H2,1H3,(H3,21,22)/b12-10+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174051
PNG
(US9688668, 18)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1coc(n1)C(C)C(N)=N
Show InChI InChI=1S/C24H37N3O/c1-3-4-5-6-7-8-9-10-11-12-13-20-14-16-21(17-15-20)22-18-28-24(27-22)19(2)23(25)26/h14-19H,3-13H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174052
PNG
(US9688668, 19)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1coc(CC(N)=N)n1
Show InChI InChI=1S/C23H35N3O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)21-18-27-23(26-21)17-22(24)25/h13-16,18H,2-12,17H2,1H3,(H3,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174073
PNG
(US9688668, 37)
Show SMILES NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(I)cc1
Show InChI InChI=1S/C13H14IN5O/c14-9-5-3-8(4-6-9)11-17-12(20-18-11)10-2-1-7-19(10)13(15)16/h3-6,10H,1-2,7H2,(H3,15,16)/t10-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174075
PNG
(US9688668, 39)
Show SMILES CCCCCCCCc1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C15H27N5O/c1-2-3-4-5-6-7-10-13-18-14(21-19-13)12-9-8-11-20(12)15(16)17/h12H,2-11H2,1H3,(H3,16,17)/t12-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174079
PNG
(US9688668, 41)
Show SMILES CCCCCCCCCCCCCCCCc1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C23H43N5O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-21-26-22(29-27-21)20-17-16-19-28(20)23(24)25/h20H,2-19H2,1H3,(H3,24,25)/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174083
PNG
(US9688668, 44)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)NC(N)=N
Show InChI InChI=1S/C24H37N5O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)21-27-22(30-29-21)24(17-18-24)28-23(25)26/h13-16H,2-12,17-18H2,1H3,(H4,25,26,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174084
PNG
(US9688668, 45)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(CN(C)C(N)=N)n1
Show InChI InChI=1S/C19H29N5O/c1-3-4-5-6-7-8-9-15-10-12-16(13-11-15)18-22-17(25-23-18)14-24(2)19(20)21/h10-13H,3-9,14H2,1-2H3,(H3,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174085
PNG
(US9688668, 46)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(CNC(N)=N)n1
Show InChI InChI=1S/C18H27N5O/c1-2-3-4-5-6-7-8-14-9-11-15(12-10-14)17-22-16(24-23-17)13-21-18(19)20/h9-12H,2-8,13H2,1H3,(H4,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174098
PNG
((S)-2-(3-(4-decylphenyl)-1,2,4-oxadiazol- 5-yl)pyr...)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C23H35N5O/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-26-22(29-27-21)20-12-10-17-28(20)23(24)25/h13-16,20H,2-12,17H2,1H3,(H3,24,25)/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174107
PNG
(US9688668, 59)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN(C1)C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)19-24-20(27-25-19)18-13-14-26(15-18)21(22)23/h9-12,18H,2-8,13-15H2,1H3,(H3,22,23)/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174009
PNG
(US9688668, 1)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)C(=O)NNC(N)=N
Show InChI InChI=1S/C20H34N4O/c1-2-3-4-5-6-7-8-9-10-11-12-17-13-15-18(16-14-17)19(25)23-24-20(21)22/h13-16H,2-12H2,1H3,(H,23,25)(H4,21,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174074
PNG
(US9688668, 38)
Show SMILES NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(cc1)C#CC1CCCC1
Show InChI InChI=1S/C20H23N5O/c21-20(22)25-13-3-6-17(25)19-23-18(24-26-19)16-11-9-15(10-12-16)8-7-14-4-1-2-5-14/h9-12,14,17H,1-6,13H2,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174082
PNG
(US9688668, 43)
Show SMILES CCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)NC(N)=N
Show InChI InChI=1S/C23H35N5O/c1-2-3-4-5-6-7-8-9-10-11-18-12-14-19(15-13-18)20-26-21(29-28-20)23(16-17-23)27-22(24)25/h12-15H,2-11,16-17H2,1H3,(H4,24,25,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174082
PNG
(US9688668, 43)
Show SMILES CCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)NC(N)=N
Show InChI InChI=1S/C23H35N5O/c1-2-3-4-5-6-7-8-9-10-11-18-12-14-19(15-13-18)20-26-21(29-28-20)23(16-17-23)27-22(24)25/h12-15H,2-11,16-17H2,1H3,(H4,24,25,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174107
PNG
(US9688668, 59)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN(C1)C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)19-24-20(27-25-19)18-13-14-26(15-18)21(22)23/h9-12,18H,2-8,13-15H2,1H3,(H3,22,23)/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174118
PNG
(US9688668, 67)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1CN(C1)C(N)=N
Show InChI InChI=1S/C22H33N5O/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)20-25-21(28-26-20)19-15-27(16-19)22(23)24/h11-14,19H,2-10,15-16H2,1H3,(H3,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174123
PNG
(US9688668, 76)
Show SMILES CCCCCCCCCCCCc1noc(C[C@@H]2CCCN2C(N)=N)n1
Show InChI InChI=1S/C20H37N5O/c1-2-3-4-5-6-7-8-9-10-11-14-18-23-19(26-24-18)16-17-13-12-15-25(17)20(21)22/h17H,2-16H2,1H3,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174022
PNG
(US9688668, 4)
Show SMILES CCCCCCCCCCCCC\C=C\CC(N)=N
Show InChI InChI=1S/C17H34N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h14-15H,2-13,16H2,1H3,(H3,18,19)/b15-14+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174023
PNG
(US9688668, 5)
Show SMILES CCCCCCCCCCc1ccc(CCCC(N)=N)cc1
Show InChI InChI=1S/C20H34N2/c1-2-3-4-5-6-7-8-9-11-18-14-16-19(17-15-18)12-10-13-20(21)22/h14-17H,2-13H2,1H3,(H3,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174051
PNG
(US9688668, 18)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1coc(n1)C(C)C(N)=N
Show InChI InChI=1S/C24H37N3O/c1-3-4-5-6-7-8-9-10-11-12-13-20-14-16-21(17-15-20)22-18-28-24(27-22)19(2)23(25)26/h14-19H,3-13H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174052
PNG
(US9688668, 19)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1coc(CC(N)=N)n1
Show InChI InChI=1S/C23H35N3O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)21-18-27-23(26-21)17-22(24)25/h13-16,18H,2-12,17H2,1H3,(H3,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174074
PNG
(US9688668, 38)
Show SMILES NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(cc1)C#CC1CCCC1
Show InChI InChI=1S/C20H23N5O/c21-20(22)25-13-3-6-17(25)19-23-18(24-26-19)16-11-9-15(10-12-16)8-7-14-4-1-2-5-14/h9-12,14,17H,1-6,13H2,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174083
PNG
(US9688668, 44)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)NC(N)=N
Show InChI InChI=1S/C24H37N5O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)21-27-22(30-29-21)24(17-18-24)28-23(25)26/h13-16H,2-12,17-18H2,1H3,(H4,25,26,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174084
PNG
(US9688668, 45)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(CN(C)C(N)=N)n1
Show InChI InChI=1S/C19H29N5O/c1-3-4-5-6-7-8-9-15-10-12-16(13-11-15)18-22-17(25-23-18)14-24(2)19(20)21/h10-13H,3-9,14H2,1-2H3,(H3,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174109
PNG
((S)-2-(3-(4-hexylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Show SMILES CCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(N)=N
Show InChI InChI=1S/C18H25N5O/c1-2-3-4-5-6-13-7-9-14(10-8-13)16-21-17(24-22-16)15-11-12-23(15)18(19)20/h7-10,15H,2-6,11-12H2,1H3,(H3,19,20)/t15-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174121
PNG
(US9688668, 74)
Show SMILES CCCCCCCCc1cccc(c1)-c1noc(C[C@@H]2CCCN2C(N)=N)n1
Show InChI InChI=1S/C22H33N5O/c1-2-3-4-5-6-7-10-17-11-8-12-18(15-17)21-25-20(28-26-21)16-19-13-9-14-27(19)22(23)24/h8,11-12,15,19H,2-7,9-10,13-14,16H2,1H3,(H3,23,24)/t19-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174124
PNG
(US9688668, 77)
Show SMILES NC(=N)N1CCC[C@H]1Cc1nc(no1)-c1ccc(CS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H23N5O3S/c22-21(23)26-12-4-5-17(26)13-19-24-20(25-29-19)16-10-8-15(9-11-16)14-30(27,28)18-6-2-1-3-7-18/h1-3,6-11,17H,4-5,12-14H2,(H3,22,23)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174010
PNG
(US9688668, 2)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)C(N)=N
Show InChI InChI=1S/C18H37N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(22)17(19)18(20)21/h14-17,22H,2-13,19H2,1H3,(H3,20,21)/b15-14+/t16-,17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174022
PNG
(US9688668, 4)
Show SMILES CCCCCCCCCCCCC\C=C\CC(N)=N
Show InChI InChI=1S/C17H34N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h14-15H,2-13,16H2,1H3,(H3,18,19)/b15-14+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174038
PNG
(US9688668, 8)
Show SMILES CCCCCCCCc1ccc(CC[C@@H](N)C(N)=N)cc1
Show InChI InChI=1S/C18H31N3/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)13-14-17(19)18(20)21/h9-12,17H,2-8,13-14,19H2,1H3,(H3,20,21)/t17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174069
PNG
(US9688668, 33)
Show SMILES CCCCCCCCc1ccc(cc1)C(=O)NCCOC(N)=N
Show InChI InChI=1S/C18H29N3O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)17(22)21-13-14-23-18(19)20/h9-12H,2-8,13-14H2,1H3,(H3,19,20)(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174070
PNG
(US9688668, 34)
Show SMILES CCCCCCCCc1ccc(cc1)[C@H]1CC[C@@H](CC1)NC(N)=N
Show InChI InChI=1S/C21H35N3/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)24-21(22)23/h9-12,19-20H,2-8,13-16H2,1H3,(H4,22,23,24)/t19-,20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM50139650
PNG
(CHEMBL3546834 | US9688668, 50)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174094
PNG
(US9688668, 51)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1C[C@@H](O)CN1C(N)=N
Show InChI InChI=1S/C21H31N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)19-24-20(28-25-19)18-13-17(27)14-26(18)21(22)23/h9-12,17-18,27H,2-8,13-14H2,1H3,(H3,22,23)/t17-,18+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174097
PNG
(US9688668, 53)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H]1C[C@H](O)CN1C(N)=N
Show InChI InChI=1S/C21H31N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)19-24-20(28-25-19)18-13-17(27)14-26(18)21(22)23/h9-12,17-18,27H,2-8,13-14H2,1H3,(H3,22,23)/t17-,18+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174105
PNG
(US9688668, 57)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C27H43N5O/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-22-17-19-23(20-18-22)25-30-26(33-31-25)24-16-14-21-32(24)27(28)29/h17-20,24H,2-16,21H2,1H3,(H3,28,29)/t24-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174106
PNG
(US9688668, 58)
Show SMILES CCCCCCCCc1cccc(c1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-10-16-11-8-12-17(15-16)19-24-20(27-25-19)18-13-9-14-26(18)21(22)23/h8,11-12,15,18H,2-7,9-10,13-14H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174108
PNG
(US9688668, 60)
Show SMILES NC(=N)N1CC[C@H]1C1CCC(C1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H25N3/c22-21(23)24-13-12-20(24)19-11-10-18(14-19)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-9,18-20H,10-14H2,(H3,22,23)/t18?,19?,20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174110
PNG
((S)-2-(3-(4-octylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(N)=N
Show InChI InChI=1S/C20H29N5O/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-14-25(17)20(21)22/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174115
PNG
(US9688668, 65)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(=N)NO
Show InChI InChI=1S/C20H29N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-22-19(27-24-18)17-13-14-25(17)20(21)23-26/h9-12,17,26H,2-8,13-14H2,1H3,(H2,21,23)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174120
PNG
(US9688668, 71)
Show SMILES CCCCCCCCc1ccc(cc1)-c1nc(no1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)20-24-19(25-27-20)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174121
PNG
(US9688668, 74)
Show SMILES CCCCCCCCc1cccc(c1)-c1noc(C[C@@H]2CCCN2C(N)=N)n1
Show InChI InChI=1S/C22H33N5O/c1-2-3-4-5-6-7-10-17-11-8-12-18(15-17)21-25-20(28-26-21)16-19-13-9-14-27(19)22(23)24/h8,11-12,15,19H,2-7,9-10,13-14,16H2,1H3,(H3,23,24)/t19-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174028
PNG
(US9688668, 7)
Show SMILES CCCCCCCCCCc1ccc(\C=C\C2(CC2)C(N)=N)cc1
Show InChI InChI=1S/C22H34N2/c1-2-3-4-5-6-7-8-9-10-19-11-13-20(14-12-19)15-16-22(17-18-22)21(23)24/h11-16H,2-10,17-18H2,1H3,(H3,23,24)/b16-15+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174071
PNG
(US9688668, 35)
Show SMILES CCCCCCCCc1ccc(CNC(=O)C2(CC2)NC(N)=N)cc1
Show InChI InChI=1S/C20H32N4O/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)15-23-18(25)20(13-14-20)24-19(21)22/h9-12H,2-8,13-15H2,1H3,(H,23,25)(H4,21,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174073
PNG
(US9688668, 37)
Show SMILES NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(I)cc1
Show InChI InChI=1S/C13H14IN5O/c14-9-5-3-8(4-6-9)11-17-12(20-18-11)10-2-1-7-19(10)13(15)16/h3-6,10H,1-2,7H2,(H3,15,16)/t10-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174075
PNG
(US9688668, 39)
Show SMILES CCCCCCCCc1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C15H27N5O/c1-2-3-4-5-6-7-10-13-18-14(21-19-13)12-9-8-11-20(12)15(16)17/h12H,2-11H2,1H3,(H3,16,17)/t12-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174076
PNG
(US9688668, 40)
Show SMILES CCCCCCCCCCCCc1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C19H35N5O/c1-2-3-4-5-6-7-8-9-10-11-14-17-22-18(25-23-17)16-13-12-15-24(16)19(20)21/h16H,2-15H2,1H3,(H3,20,21)/t16-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174080
PNG
(US9688668, 42)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)NC(N)=N
Show InChI InChI=1S/C20H29N5O/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)17-23-18(26-25-17)20(13-14-20)24-19(21)22/h9-12H,2-8,13-14H2,1H3,(H4,21,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174097
PNG
(US9688668, 53)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H]1C[C@H](O)CN1C(N)=N
Show InChI InChI=1S/C21H31N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)19-24-20(28-25-19)18-13-17(27)14-26(18)21(22)23/h9-12,17-18,27H,2-8,13-14H2,1H3,(H3,22,23)/t17-,18+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174115
PNG
(US9688668, 65)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(=N)NO
Show InChI InChI=1S/C20H29N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-22-19(27-24-18)17-13-14-25(17)20(21)23-26/h9-12,17,26H,2-8,13-14H2,1H3,(H2,21,23)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174119
PNG
(US9688668, 68)
Show SMILES NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(CS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H21N5O3S/c21-20(22)25-12-4-7-17(25)19-23-18(24-28-19)15-10-8-14(9-11-15)13-29(26,27)16-5-2-1-3-6-16/h1-3,5-6,8-11,17H,4,7,12-13H2,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174122
PNG
(US9688668, 75)
Show SMILES CCCCCCCc1cccc(c1)-c1noc(C[C@@H]2CCCN2C(N)=N)n1
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-9-16-10-7-11-17(14-16)20-24-19(27-25-20)15-18-12-8-13-26(18)21(22)23/h7,10-11,14,18H,2-6,8-9,12-13,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174122
PNG
(US9688668, 75)
Show SMILES CCCCCCCc1cccc(c1)-c1noc(C[C@@H]2CCCN2C(N)=N)n1
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-9-16-10-7-11-17(14-16)20-24-19(27-25-20)15-18-12-8-13-26(18)21(22)23/h7,10-11,14,18H,2-6,8-9,12-13,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174010
PNG
(US9688668, 2)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)C(N)=N
Show InChI InChI=1S/C18H37N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(22)17(19)18(20)21/h14-17,22H,2-13,19H2,1H3,(H3,20,21)/b15-14+/t16-,17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174023
PNG
(US9688668, 5)
Show SMILES CCCCCCCCCCc1ccc(CCCC(N)=N)cc1
Show InChI InChI=1S/C20H34N2/c1-2-3-4-5-6-7-8-9-11-18-14-16-19(17-15-18)12-10-13-20(21)22/h14-17H,2-13H2,1H3,(H3,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174026
PNG
(US9688668, 6)
Show SMILES CCCCCCCCCCc1ccc(\C=C\CC(N)=N)cc1
Show InChI InChI=1S/C20H32N2/c1-2-3-4-5-6-7-8-9-11-18-14-16-19(17-15-18)12-10-13-20(21)22/h10,12,14-17H,2-9,11,13H2,1H3,(H3,21,22)/b12-10+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174028
PNG
(US9688668, 7)
Show SMILES CCCCCCCCCCc1ccc(\C=C\C2(CC2)C(N)=N)cc1
Show InChI InChI=1S/C22H34N2/c1-2-3-4-5-6-7-8-9-10-19-11-13-20(14-12-19)15-16-22(17-18-22)21(23)24/h11-16H,2-10,17-18H2,1H3,(H3,23,24)/b16-15+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174043
PNG
(US9688668, 12)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1noc(CC(N)=N)n1
Show InChI InChI=1S/C22H34N4O/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)22-25-21(27-26-22)17-20(23)24/h13-16H,2-12,17H2,1H3,(H3,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174069
PNG
(US9688668, 33)
Show SMILES CCCCCCCCc1ccc(cc1)C(=O)NCCOC(N)=N
Show InChI InChI=1S/C18H29N3O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)17(22)21-13-14-23-18(19)20/h9-12H,2-8,13-14H2,1H3,(H3,19,20)(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174071
PNG
(US9688668, 35)
Show SMILES CCCCCCCCc1ccc(CNC(=O)C2(CC2)NC(N)=N)cc1
Show InChI InChI=1S/C20H32N4O/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)15-23-18(25)20(13-14-20)24-19(21)22/h9-12H,2-8,13-15H2,1H3,(H,23,25)(H4,21,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174076
PNG
(US9688668, 40)
Show SMILES CCCCCCCCCCCCc1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C19H35N5O/c1-2-3-4-5-6-7-8-9-10-11-14-17-22-18(25-23-17)16-13-12-15-24(16)19(20)21/h16H,2-15H2,1H3,(H3,20,21)/t16-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174079
PNG
(US9688668, 41)
Show SMILES CCCCCCCCCCCCCCCCc1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C23H43N5O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-21-26-22(29-27-21)20-17-16-19-28(20)23(24)25/h20H,2-19H2,1H3,(H3,24,25)/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM50443388
PNG
(CHEMBL3086782 | US9688668, SLR080811)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174106
PNG
(US9688668, 58)
Show SMILES CCCCCCCCc1cccc(c1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-10-16-11-8-12-17(15-16)19-24-20(27-25-19)18-13-9-14-26(18)21(22)23/h8,11-12,15,18H,2-7,9-10,13-14H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174043
PNG
(US9688668, 12)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1noc(CC(N)=N)n1
Show InChI InChI=1S/C22H34N4O/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)22-25-21(27-26-22)17-20(23)24/h13-16H,2-12,17H2,1H3,(H3,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174080
PNG
(US9688668, 42)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)NC(N)=N
Show InChI InChI=1S/C20H29N5O/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)17-23-18(26-25-17)20(13-14-20)24-19(21)22/h9-12H,2-8,13-14H2,1H3,(H4,21,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174124
PNG
(US9688668, 77)
Show SMILES NC(=N)N1CCC[C@H]1Cc1nc(no1)-c1ccc(CS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H23N5O3S/c22-21(23)26-12-4-5-17(26)13-19-24-20(25-29-19)16-10-8-15(9-11-16)14-30(27,28)18-6-2-1-3-7-18/h1-3,6-11,17H,4-5,12-14H2,(H3,22,23)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174009
PNG
(US9688668, 1)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)C(=O)NNC(N)=N
Show InChI InChI=1S/C20H34N4O/c1-2-3-4-5-6-7-8-9-10-11-12-17-13-15-18(16-14-17)19(25)23-24-20(21)22/h13-16H,2-12H2,1H3,(H,23,25)(H4,21,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174038
PNG
(US9688668, 8)
Show SMILES CCCCCCCCc1ccc(CC[C@@H](N)C(N)=N)cc1
Show InChI InChI=1S/C18H31N3/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)13-14-17(19)18(20)21/h9-12,17H,2-8,13-14,19H2,1H3,(H3,20,21)/t17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174049
PNG
(US9688668, 16)
Show SMILES CCCCCCCCCCCCc1cccc(c1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-2-3-4-5-6-7-8-9-10-11-13-19-14-12-15-20(18-19)21-27-23(29-28-21)24(16-17-24)22(25)26/h12,14-15,18H,2-11,13,16-17H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174072
PNG
(US9688668, 36)
Show SMILES CCCCCCCCCCCCc1ccc(NC(=O)C2(CC2)NC(N)=N)cc1
Show InChI InChI=1S/C23H38N4O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)26-21(28)23(17-18-23)27-22(24)25/h13-16H,2-12,17-18H2,1H3,(H,26,28)(H4,24,25,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174072
PNG
(US9688668, 36)
Show SMILES CCCCCCCCCCCCc1ccc(NC(=O)C2(CC2)NC(N)=N)cc1
Show InChI InChI=1S/C23H38N4O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)26-21(28)23(17-18-23)27-22(24)25/h13-16H,2-12,17-18H2,1H3,(H,26,28)(H4,24,25,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM50443388
PNG
(CHEMBL3086782 | US9688668, SLR080811)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM50443388
PNG
(CHEMBL3086782 | US9688668, SLR080811)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.20E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174090
PNG
(US9688668, 48)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H](NC(N)=N)C(C)C
Show InChI InChI=1S/C21H33N5O/c1-4-5-6-7-8-9-10-16-11-13-17(14-12-16)19-25-20(27-26-19)18(15(2)3)24-21(22)23/h11-15,18H,4-10H2,1-3H3,(H4,22,23,24)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174098
PNG
((S)-2-(3-(4-decylphenyl)-1,2,4-oxadiazol- 5-yl)pyr...)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C23H35N5O/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-26-22(29-27-21)20-12-10-17-28(20)23(24)25/h13-16,20H,2-12,17H2,1H3,(H3,24,25)/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174105
PNG
(US9688668, 57)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C27H43N5O/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-22-17-19-23(20-18-22)25-30-26(33-31-25)24-16-14-21-32(24)27(28)29/h17-20,24H,2-16,21H2,1H3,(H3,28,29)/t24-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174059
PNG
(US9688668, 24)
Show SMILES CCCCCCCCCCCc1ccc(OC)c(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O2/c1-3-4-5-6-7-8-9-10-11-12-18-13-14-20(29-2)19(17-18)21-27-28-23(30-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174065
PNG
(US9688668, 29)
Show SMILES CCCCCCCCCCCc1cc(ccc1F)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H33FN4O/c1-2-3-4-5-6-7-8-9-10-11-17-16-18(12-13-19(17)24)20-27-28-22(29-20)23(14-15-23)21(25)26/h12-13,16H,2-11,14-15H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174085
PNG
(US9688668, 46)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(CNC(N)=N)n1
Show InChI InChI=1S/C18H27N5O/c1-2-3-4-5-6-7-8-14-9-11-15(12-10-14)17-22-16(24-23-17)13-21-18(19)20/h9-12H,2-8,13H2,1H3,(H4,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174088
PNG
(US9688668, 47)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H](C)NC(N)=N
Show InChI InChI=1S/C19H29N5O/c1-3-4-5-6-7-8-9-15-10-12-16(13-11-15)17-23-18(25-24-17)14(2)22-19(20)21/h10-14H,3-9H2,1-2H3,(H4,20,21,22)/t14-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174090
PNG
(US9688668, 48)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H](NC(N)=N)C(C)C
Show InChI InChI=1S/C21H33N5O/c1-4-5-6-7-8-9-10-16-11-13-17(14-12-16)19-25-20(27-26-19)18(15(2)3)24-21(22)23/h11-15,18H,4-10H2,1-3H3,(H4,22,23,24)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174110
PNG
((S)-2-(3-(4-octylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(N)=N
Show InChI InChI=1S/C20H29N5O/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-14-25(17)20(21)22/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174041
PNG
(US9688668, 10)
Show SMILES CCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H34N4O/c1-2-3-4-5-6-7-8-9-10-11-18-12-14-19(15-13-18)20-26-22(28-27-20)23(16-17-23)21(24)25/h12-15H,2-11,16-17H2,1H3,(H3,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174044
PNG
(US9688668, 13)
Show SMILES NC(=N)C1(CC1)c1nc(no1)-c1cccc(CCc2cccc(CCC3CCCCC3)c2)c1
Show InChI InChI=1S/C28H34N4O/c29-26(30)28(16-17-28)27-31-25(32-33-27)24-11-5-10-23(19-24)15-14-22-9-4-8-21(18-22)13-12-20-6-2-1-3-7-20/h4-5,8-11,18-20H,1-3,6-7,12-17H2,(H3,29,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174047
PNG
(US9688668, 15)
Show SMILES CCCCCCCCCCCc1cc(ccc1C)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-3-4-5-6-7-8-9-10-11-12-19-17-20(14-13-18(19)2)21-27-23(29-28-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174053
PNG
(US9688668, 20)
Show SMILES CCCCCCCCCCCCc1cccc(c1)-c1coc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C25H37N3O/c1-2-3-4-5-6-7-8-9-10-11-13-20-14-12-15-21(18-20)22-19-29-24(28-22)25(16-17-25)23(26)27/h12,14-15,18-19H,2-11,13,16-17H2,1H3,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174056
PNG
(US9688668, 23)
Show SMILES CCCCCCCCCCCc1ccc(C)c(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-3-4-5-6-7-8-9-10-11-12-19-14-13-18(2)20(17-19)21-27-28-23(29-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174088
PNG
(US9688668, 47)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H](C)NC(N)=N
Show InChI InChI=1S/C19H29N5O/c1-3-4-5-6-7-8-9-15-10-12-16(13-11-15)17-23-18(25-24-17)14(2)22-19(20)21/h10-14H,3-9H2,1-2H3,(H4,20,21,22)/t14-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174098
PNG
((S)-2-(3-(4-decylphenyl)-1,2,4-oxadiazol- 5-yl)pyr...)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C23H35N5O/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-26-22(29-27-21)20-12-10-17-28(20)23(24)25/h13-16,20H,2-12,17H2,1H3,(H3,24,25)/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174042
PNG
(US9688668, 11)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)21-27-23(29-28-21)24(17-18-24)22(25)26/h13-16H,2-12,17-18H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174046
PNG
(US9688668, 14)
Show SMILES CCCCCCCCCCCc1cc(ccc1CO)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-16-19(12-13-20(18)17-29)21-27-23(30-28-21)24(14-15-24)22(25)26/h12-13,16,29H,2-11,14-15,17H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174094
PNG
(US9688668, 51)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1C[C@@H](O)CN1C(N)=N
Show InChI InChI=1S/C21H31N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)19-24-20(28-25-19)18-13-17(27)14-26(18)21(22)23/h9-12,17-18,27H,2-8,13-14H2,1H3,(H3,22,23)/t17-,18+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174096
PNG
(US9688668, 52)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1[C@@H](O)CCN1C(N)=N
Show InChI InChI=1S/C21H31N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)19-24-20(28-25-19)18-17(27)13-14-26(18)21(22)23/h9-12,17-18,27H,2-8,13-14H2,1H3,(H3,22,23)/t17-,18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174019
PNG
(US9688668, 3)
Show SMILES CCCCCCCCCCCCCCCCC(N)=N
Show InChI InChI=1S/C17H36N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H3,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174040
PNG
(US9688668, 9)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C22H32N4O/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)19-25-21(27-26-19)22(15-16-22)20(23)24/h11-14H,2-10,15-16H2,1H3,(H3,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174042
PNG
(US9688668, 11)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-15-20(16-14-19)21-27-23(29-28-21)24(17-18-24)22(25)26/h13-16H,2-12,17-18H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174055
PNG
(US9688668, 22)
Show SMILES CCCCCCCCCCCc1cc(-c2nnc(o2)C2(CC2)C(N)=N)c(OC)cc1OC
Show InChI InChI=1S/C25H38N4O3/c1-4-5-6-7-8-9-10-11-12-13-18-16-19(21(31-3)17-20(18)30-2)22-28-29-24(32-22)25(14-15-25)23(26)27/h16-17H,4-15H2,1-3H3,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174060
PNG
(US9688668, 25)
Show SMILES CCCCCCCCCCCc1ccc(F)c(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H33FN4O/c1-2-3-4-5-6-7-8-9-10-11-17-12-13-19(24)18(16-17)20-27-28-22(29-20)23(14-15-23)21(25)26/h12-13,16H,2-11,14-15H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174067
PNG
(US9688668, 31)
Show SMILES NC(=N)C1(CC1)c1nnc(o1)-c1cccc(CCCCCCOCC2CCCCC2)c1
Show InChI InChI=1S/C25H36N4O2/c26-23(27)25(14-15-25)24-29-28-22(31-24)21-13-8-12-19(17-21)9-4-1-2-7-16-30-18-20-10-5-3-6-11-20/h8,12-13,17,20H,1-7,9-11,14-16,18H2,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174070
PNG
(US9688668, 34)
Show SMILES CCCCCCCCc1ccc(cc1)[C@H]1CC[C@@H](CC1)NC(N)=N
Show InChI InChI=1S/C21H35N3/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)24-21(22)23/h9-12,19-20H,2-8,13-16H2,1H3,(H4,22,23,24)/t19-,20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM50443388
PNG
(CHEMBL3086782 | US9688668, SLR080811)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174114
PNG
(US9688668, 64)
Show SMILES NC(=N)N1CCCC1.CCCCCCCCc1ccc(cc1)-c1noc(CC)n1
Show InChI InChI=1S/C18H26N2O.C5H11N3/c1-3-5-6-7-8-9-10-15-11-13-16(14-12-15)18-19-17(4-2)21-20-18;6-5(7)8-3-1-2-4-8/h11-14H,3-10H2,1-2H3;1-4H2,(H3,6,7)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174118
PNG
(US9688668, 67)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1CN(C1)C(N)=N
Show InChI InChI=1S/C22H33N5O/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)20-25-21(28-26-20)19-15-27(16-19)22(23)24/h11-14,19H,2-10,15-16H2,1H3,(H3,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174120
PNG
(US9688668, 71)
Show SMILES CCCCCCCCc1ccc(cc1)-c1nc(no1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)20-24-19(25-27-20)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174040
PNG
(US9688668, 9)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C22H32N4O/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)19-25-21(27-26-19)22(15-16-22)20(23)24/h11-14H,2-10,15-16H2,1H3,(H3,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174063
PNG
(US9688668, 27)
Show SMILES CCCCCCCCCCCc1cc(ccc1OC)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O2/c1-3-4-5-6-7-8-9-10-11-12-18-17-19(13-14-20(18)29-2)21-27-28-23(30-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174064
PNG
(US9688668, 28)
Show SMILES CCCCCCCCCCCc1cc(ccc1C)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-3-4-5-6-7-8-9-10-11-12-19-17-20(14-13-18(19)2)21-27-28-23(29-21)24(15-16-24)22(25)26/h13-14,17H,3-12,15-16H2,1-2H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174096
PNG
(US9688668, 52)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1[C@@H](O)CCN1C(N)=N
Show InChI InChI=1S/C21H31N5O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)19-24-20(28-25-19)18-17(27)13-14-26(18)21(22)23/h9-12,17-18,27H,2-8,13-14H2,1H3,(H3,22,23)/t17-,18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174113
PNG
(US9688668, 63)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(N)=N
Show InChI InChI=1S/C22H33N5O/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)20-25-21(28-26-20)19-15-16-27(19)22(23)24/h11-14,19H,2-10,15-16H2,1H3,(H3,23,24)/t19-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174041
PNG
(US9688668, 10)
Show SMILES CCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H34N4O/c1-2-3-4-5-6-7-8-9-10-11-18-12-14-19(15-13-18)20-26-22(28-27-20)23(16-17-23)21(24)25/h12-15H,2-11,16-17H2,1H3,(H3,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174061
PNG
(US9688668, 26)
Show SMILES CCCCCCCCCCCc1cccc(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H34N4O/c1-2-3-4-5-6-7-8-9-10-12-18-13-11-14-19(17-18)20-26-27-22(28-20)23(15-16-23)21(24)25/h11,13-14,17H,2-10,12,15-16H2,1H3,(H3,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174066
PNG
(US9688668, 30)
Show SMILES CCCCCCCCCCCCc1cccc(c1)-c1nnc(o1)C1(CC1)C(N)=N
Show InChI InChI=1S/C24H36N4O/c1-2-3-4-5-6-7-8-9-10-11-13-19-14-12-15-20(18-19)21-27-28-23(29-21)24(16-17-24)22(25)26/h12,14-15,18H,2-11,13,16-17H2,1H3,(H3,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174068
PNG
(US9688668, 32)
Show SMILES NC(=N)C1(CC1)c1nnc(o1)-c1ccc(CCCCCCCOCC2CCCCC2)cc1
Show InChI InChI=1S/C26H38N4O2/c27-24(28)26(16-17-26)25-30-29-23(32-25)22-14-12-20(13-15-22)9-5-2-1-3-8-18-31-19-21-10-6-4-7-11-21/h12-15,21H,1-11,16-19H2,(H3,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM50443388
PNG
(CHEMBL3086782 | US9688668, SLR080811)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174109
PNG
((S)-2-(3-(4-hexylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Show SMILES CCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(N)=N
Show InChI InChI=1S/C18H25N5O/c1-2-3-4-5-6-13-7-9-14(10-8-13)16-21-17(24-22-16)15-11-12-23(15)18(19)20/h7-10,15H,2-6,11-12H2,1H3,(H3,19,20)/t15-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174117
PNG
(US9688668, 66)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)C1CN(C1)C(N)=N
Show InChI InChI=1S/C20H29N5O/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-25(14-17)20(21)22/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174117
PNG
(US9688668, 66)
Show SMILES CCCCCCCCc1ccc(cc1)-c1noc(n1)C1CN(C1)C(N)=N
Show InChI InChI=1S/C20H29N5O/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-25(14-17)20(21)22/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174019
PNG
(US9688668, 3)
Show SMILES CCCCCCCCCCCCCCCCC(N)=N
Show InChI InChI=1S/C17H36N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H3,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174050
PNG
(US9688668, 17)
Show SMILES NC(=N)C1(CC1)c1nc(no1)-c1cccc(CCCCCCOCC2CCCCC2)c1
Show InChI InChI=1S/C25H36N4O2/c26-23(27)25(14-15-25)24-28-22(29-31-24)21-13-8-12-19(17-21)9-4-1-2-7-16-30-18-20-10-5-3-6-11-20/h8,12-13,17,20H,1-7,9-11,14-16,18H2,(H3,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 2 (SphK2)


(Homo sapiens (Human))
BDBM174054
PNG
(US9688668, 21)
Show SMILES CCCCCCCCCCCc1cccc(c1)-c1nc(n[nH]1)C1(CC1)C(N)=N
Show InChI InChI=1S/C23H35N5/c1-2-3-4-5-6-7-8-9-10-12-18-13-11-14-19(17-18)20-26-22(28-27-20)23(15-16-23)21(24)25/h11,13-14,17H,2-10,12,15-16H2,1H3,(H3,24,25)(H,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174098
PNG
((S)-2-(3-(4-decylphenyl)-1,2,4-oxadiazol- 5-yl)pyr...)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C23H35N5O/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-26-22(29-27-21)20-12-10-17-28(20)23(24)25/h13-16,20H,2-12,17H2,1H3,(H3,24,25)/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
Sphingosine kinase types 1 (SphK1)


(Homo sapiens (Human))
BDBM174113
PNG
(US9688668, 63)
Show SMILES CCCCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1CCN1C(N)=N
Show InChI InChI=1S/C22H33N5O/c1-2-3-4-5-6-7-8-9-10-17-11-13-18(14-12-17)20-25-21(28-26-20)19-15-16-27(19)22(23)24/h11-14,19H,2-10,15-16H2,1H3,(H3,23,24)/t19-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.50E+4n/an/an/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%