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Patent code US9688680

Compile Data Set for Download or QSAR

Found 950 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175571
PNG
(US9688680, 122)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CCNC2)cc1
Show InChI InChI=1S/C25H28N8O/c1-17-2-4-18(5-3-17)9-27-25(34)21-12-31(13-21)24-23-8-19(14-33(23)30-16-28-24)20-10-29-32(15-20)22-6-7-26-11-22/h2-5,8,10,14-16,21-22,26H,6-7,9,11-13H2,1H3,(H,27,34)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175597
PNG
(US9688680, 146)
Show SMILES CC(C)n1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](C)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN7O/c1-15(2)31-13-19(9-27-31)18-8-22-23(26-14-28-32(22)12-18)30-10-20(11-30)24(33)29-16(3)17-4-6-21(25)7-5-17/h4-9,12-16,20H,10-11H2,1-3H3,(H,29,33)/t16-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175609
PNG
(US9688680, 158)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)CCC2)cc1
Show InChI InChI=1S/C28H29N5O2/c1-19-3-5-20(6-4-19)14-29-27(34)23-15-32(16-23)26-25-13-22(17-33(25)31-18-30-26)21-7-9-24(10-8-21)28(35)11-2-12-28/h3-10,13,17-18,23,35H,2,11-12,14-16H2,1H3,(H,29,34)
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US Patent
n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175652
PNG
(US9688680, 199)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](C)c1ccc(F)cc1
Show InChI InChI=1S/C25H27FN6O3/c1-16(17-3-5-21(26)6-4-17)29-24(33)20-12-31(13-20)23-22-11-19(14-32(22)28-15-27-23)18-7-9-30(10-8-18)25(34)35-2/h3-7,11,14-16,20H,8-10,12-13H2,1-2H3,(H,29,33)/t16-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175675
PNG
(US9688680, 220)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C1(O)CCC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H28FN5O2/c1-18(19-5-9-24(29)10-6-19)32-27(35)22-14-33(15-22)26-25-13-21(16-34(25)31-17-30-26)20-3-7-23(8-4-20)28(36)11-2-12-28/h3-10,13,16-18,22,36H,2,11-12,14-15H2,1H3,(H,32,35)/t18-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175693
PNG
(US9688680, 238)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN7O2/c1-16(18-5-7-22(27)8-6-18)31-25(35)21-11-32(12-21)24-23-9-19(13-34(23)30-15-28-24)20-10-29-33(14-20)17(2)26(3,4)36/h5-10,13-17,21,36H,11-12H2,1-4H3,(H,31,35)/t16-,17-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175733
PNG
(US9688680, 278)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC(C)(C)N)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H31ClN8O/c1-4-22(17-5-7-21(27)8-6-17)32-25(36)20-11-33(12-20)24-23-9-18(14-35(23)31-16-29-24)19-10-30-34(13-19)15-26(2,3)28/h5-10,13-14,16,20,22H,4,11-12,15,28H2,1-3H3,(H,32,36)/t22-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175739
PNG
(US9688680, 284)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)[C@H](C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H30ClN7O2/c1-4-23(18-5-7-22(27)8-6-18)31-26(36)21-11-32(12-21)25-24-9-19(13-34(24)30-15-28-25)20-10-29-33(14-20)16(2)17(3)35/h5-10,13-17,21,23,35H,4,11-12H2,1-3H3,(H,31,36)/t16-,17+,23+/m1/s1
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175740
PNG
(US9688680, 285)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)[C@@H](C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H30ClN7O2/c1-4-23(18-5-7-22(27)8-6-18)31-26(36)21-11-32(12-21)25-24-9-19(13-34(24)30-15-28-25)20-10-29-33(14-20)16(2)17(3)35/h5-10,13-17,21,23,35H,4,11-12H2,1-3H3,(H,31,36)/t16-,17+,23-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175619
PNG
(US9688680, 168)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)O)cc1
Show InChI InChI=1S/C28H31N5O2/c1-19-5-7-20(8-6-19)14-29-26(34)28(4)16-32(17-28)25-24-13-22(15-33(24)31-18-30-25)21-9-11-23(12-10-21)27(2,3)35/h5-13,15,18,35H,14,16-17H2,1-4H3,(H,29,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175685
PNG
(US9688680, 230)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC2(C)COC2)c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN7O2/c1-17(18-3-5-22(27)6-4-18)31-25(35)21-9-32(10-21)24-23-7-19(12-34(23)30-16-28-24)20-8-29-33(11-20)13-26(2)14-36-15-26/h3-8,11-12,16-17,21H,9-10,13-15H2,1-2H3,(H,31,35)/t17-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175694
PNG
(US9688680, 239)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)C(C)(C)O)c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN7O2/c1-16(18-5-7-22(27)8-6-18)31-25(35)21-11-32(12-21)24-23-9-19(13-34(23)30-15-28-24)20-10-29-33(14-20)17(2)26(3,4)36/h5-10,13-17,21,36H,11-12H2,1-4H3,(H,31,35)/t16-,17+/m0/s1
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175695
PNG
(US9688680, 240)
Show SMILES OCC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn2CCCc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H26ClN7O2/c26-19-5-3-16(4-6-19)21(7-9-34)30-25(35)18-12-31(13-18)24-23-10-17(14-33(23)29-15-27-24)20-11-28-32-8-1-2-22(20)32/h3-6,10-11,14-15,18,21,34H,1-2,7-9,12-13H2,(H,30,35)/t21-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175701
PNG
(US9688680, 246)
Show SMILES CC(C)(O)c1ccc(cc1)C1=CN2C=CCN(N3CC(C3)C(=O)NCc3ccc(Cl)cc3F)N2C1
Show InChI InChI=1S/C26H29ClFN5O2/c1-26(2,35)22-7-4-18(5-8-22)20-14-30-10-3-11-32(33(30)17-20)31-15-21(16-31)25(34)29-13-19-6-9-23(27)12-24(19)28/h3-10,12,14,21,35H,11,13,15-17H2,1-2H3,(H,29,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175718
PNG
(US9688680, 263)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C24H24ClFN6O3/c1-35-24(34)30-6-4-15(5-7-30)17-8-21-22(28-14-29-32(21)13-17)31-11-18(12-31)23(33)27-10-16-2-3-19(25)9-20(16)26/h2-4,8-9,13-14,18H,5-7,10-12H2,1H3,(H,27,33)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175756
PNG
(US9688680, 301)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31ClN6O3/c1-2-25(36)32-10-7-18(8-11-32)20-13-24-26(29-17-30-34(24)16-20)33-14-21(15-33)27(37)31-23(9-12-35)19-3-5-22(28)6-4-19/h3-7,13,16-17,21,23,35H,2,8-12,14-15H2,1H3,(H,31,37)/t23-/m0/s1
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175217
PNG
(US9688680, 5)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C21H18N8O/c1-27-9-16(8-24-27)15-6-19-20(23-13-25-29(19)12-15)28-10-17(11-28)21(30)26-18-4-2-14(7-22)3-5-18/h2-6,8-9,12-13,17H,10-11H2,1H3,(H,26,30)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175215
PNG
(US9688680, 3 | US9688680, 6)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C22H23N7O/c1-15-3-5-16(6-4-15)8-23-22(30)19-11-28(12-19)21-20-7-17(13-29(20)26-14-24-21)18-9-25-27(2)10-18/h3-7,9-10,13-14,19H,8,11-12H2,1-2H3,(H,23,30)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175225
PNG
(US9688680, 12)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCOCC2)cc1
Show InChI InChI=1S/C23H25N5O2/c1-16-2-4-17(5-3-16)11-24-23(29)20-12-27(13-20)22-21-10-19(14-28(21)26-15-25-22)18-6-8-30-9-7-18/h2-6,10,14-15,20H,7-9,11-13H2,1H3,(H,24,29)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175474
PNG
(US9688680, 74)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2CC2)cc1
Show InChI InChI=1S/C27H27N5O/c1-18-2-4-19(5-3-18)13-28-27(33)24-14-31(15-24)26-25-12-23(16-32(25)30-17-29-26)22-10-8-21(9-11-22)20-6-7-20/h2-5,8-12,16-17,20,24H,6-7,13-15H2,1H3,(H,28,33)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175479
PNG
(US9688680, 79)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CCC2)cc1
Show InChI InChI=1S/C25H27N7O/c1-17-5-7-18(8-6-17)10-26-25(33)21-12-30(13-21)24-23-9-19(14-32(23)29-16-27-24)20-11-28-31(15-20)22-3-2-4-22/h5-9,11,14-16,21-22H,2-4,10,12-13H2,1H3,(H,26,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175480
PNG
(US9688680, 80)
Show SMILES CN(C)c1ccc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H27N7O/c1-17-4-6-18(7-5-17)11-27-25(33)21-13-31(14-21)24-22-10-20(15-32(22)29-16-28-24)19-8-9-23(26-12-19)30(2)3/h4-10,12,15-16,21H,11,13-14H2,1-3H3,(H,27,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175520
PNG
(US9688680, 103)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CO)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN7O2/c1-28-8-16(7-25-28)15-6-20-21(24-13-26-30(20)11-15)29-9-17(10-29)22(32)27-19(12-31)14-2-4-18(23)5-3-14/h2-8,11,13,17,19,31H,9-10,12H2,1H3,(H,27,32)/t19-/m0/s1
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175577
PNG
(US9688680, 126)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O2/c1-3-24(33)30-10-8-20(9-11-30)21-12-23-25(28-17-29-32(23)16-21)31-14-22(15-31)26(34)27-13-19-6-4-18(2)5-7-19/h4-8,12,16-17,22H,3,9-11,13-15H2,1-2H3,(H,27,34)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175598
PNG
(US9688680, 147)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)C#N)cc1
Show InChI InChI=1S/C28H28N6O/c1-19-4-6-20(7-5-19)13-30-27(35)23-14-33(15-23)26-25-12-22(16-34(25)32-18-31-26)21-8-10-24(11-9-21)28(2,3)17-29/h4-12,16,18,23H,13-15H2,1-3H3,(H,30,35)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175605
PNG
(US9688680, 154)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc3C(=O)NCc3c2)cc1
Show InChI InChI=1S/C27H26N6O2/c1-17-3-5-18(6-4-17)11-29-26(35)27(2)14-32(15-27)24-23-10-21(13-33(23)31-16-30-24)19-7-8-22-20(9-19)12-28-25(22)34/h3-10,13,16H,11-12,14-15H2,1-2H3,(H,28,34)(H,29,35)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175677
PNG
(US9688680, 222)
Show SMILES COC1(CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C(C)(C)O)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C28H31N5O3/c1-19-5-7-20(8-6-19)14-29-26(34)28(36-4)16-32(17-28)25-24-13-22(15-33(24)31-18-30-25)21-9-11-23(12-10-21)27(2,3)35/h5-13,15,18,35H,14,16-17H2,1-4H3,(H,29,34)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175707
PNG
(US9688680, 252)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-20-4-6-21(7-5-20)15-30-28(36)25-16-34(17-25)27-26-14-24(18-35(26)32-19-31-27)22-8-10-23(11-9-22)29(37)33-12-2-3-13-33/h4-11,14,18-19,25H,2-3,12-13,15-17H2,1H3,(H,30,36)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175720
PNG
(US9688680, 265)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C28H33N7O2/c1-20-4-6-21(7-5-20)15-29-27(36)24-16-34(17-24)26-25-14-23(18-35(25)31-19-30-26)22-8-12-33(13-9-22)28(37)32-10-2-3-11-32/h4-8,14,18-19,24H,2-3,9-13,15-17H2,1H3,(H,29,36)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175722
PNG
(US9688680, 267)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C28H34N6O3/c1-19-5-7-20(8-6-19)14-29-26(35)23-15-33(16-23)25-24-13-22(17-34(24)31-18-30-25)21-9-11-32(12-10-21)27(36)37-28(2,3)4/h5-9,13,17-18,23H,10-12,14-16H2,1-4H3,(H,29,35)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175742
PNG
(US9688680, 287)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(O)C(F)(F)F)cc1
Show InChI InChI=1S/C27H26F3N5O2/c1-17-3-5-18(6-4-17)12-31-25(36)21-13-34(14-21)24-23-11-20(15-35(23)33-16-32-24)19-7-9-22(10-8-19)26(2,37)27(28,29)30/h3-11,15-16,21,37H,12-14H2,1-2H3,(H,31,36)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175227
PNG
(US9688680, 14)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)s1
Show InChI InChI=1S/C20H21N7OS/c1-13-3-4-17(29-13)7-21-20(28)16-9-26(10-16)19-18-5-14(11-27(18)24-12-22-19)15-6-23-25(2)8-15/h3-6,8,11-12,16H,7,9-10H2,1-2H3,(H,21,28)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175447
PNG
(US9688680, 47)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CC2)cc1
Show InChI InChI=1S/C24H25N7O/c1-16-2-4-17(5-3-16)9-25-24(32)20-11-29(12-20)23-22-8-18(13-31(22)28-15-26-23)19-10-27-30(14-19)21-6-7-21/h2-5,8,10,13-15,20-21H,6-7,9,11-12H2,1H3,(H,25,32)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175492
PNG
(US9688680, 92)
Show SMILES COc1ccc(cc1F)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H24FN5O2/c1-16-3-5-17(6-4-16)11-27-25(32)20-12-30(13-20)24-22-10-19(14-31(22)29-15-28-24)18-7-8-23(33-2)21(26)9-18/h3-10,14-15,20H,11-13H2,1-2H3,(H,27,32)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175536
PNG
(US9688680, 107)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N6O2/c1-26(2,34)21-7-5-18(6-8-21)19-11-23-24(28-16-29-32(23)15-19)31-13-20(14-31)25(33)30-22-9-3-17(12-27)4-10-22/h3-11,15-16,20,34H,13-14H2,1-2H3,(H,30,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175555
PNG
(US9688680, 109)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(OC3CC3)cc2)cc1
Show InChI InChI=1S/C27H27N5O2/c1-18-2-4-19(5-3-18)13-28-27(33)22-14-31(15-22)26-25-12-21(16-32(25)30-17-29-26)20-6-8-23(9-7-20)34-24-10-11-24/h2-9,12,16-17,22,24H,10-11,13-15H2,1H3,(H,28,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175565
PNG
(US9688680, 116)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cccc(c2)C(C)(C)O)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18-7-9-19(10-8-18)13-28-26(33)22-14-31(15-22)25-24-12-21(16-32(24)30-17-29-25)20-5-4-6-23(11-20)27(2,3)34/h4-12,16-17,22,34H,13-15H2,1-3H3,(H,28,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175569
PNG
(US9688680, 120)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl2N7O/c1-28-8-15(7-26-28)14-4-19-20(25-12-27-30(19)11-14)29-9-16(10-29)21(31)24-6-13-2-3-17(22)5-18(13)23/h2-5,7-8,11-12,16H,6,9-10H2,1H3,(H,24,31)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175615
PNG
(US9688680, 164)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)COC2)cc1
Show InChI InChI=1S/C27H27N5O3/c1-18-2-4-19(5-3-18)11-28-26(33)22-12-31(13-22)25-24-10-21(14-32(24)30-17-29-25)20-6-8-23(9-7-20)27(34)15-35-16-27/h2-10,14,17,22,34H,11-13,15-16H2,1H3,(H,28,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175626
PNG
(US9688680, 175)
Show SMILES COCCOc1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H29N5O3/c1-19-3-5-20(6-4-19)14-28-27(33)23-15-31(16-23)26-25-13-22(17-32(25)30-18-29-26)21-7-9-24(10-8-21)35-12-11-34-2/h3-10,13,17-18,23H,11-12,14-16H2,1-2H3,(H,28,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175630
PNG
(US9688680, 179)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H32N6O2/c1-4-24(34)31-11-9-21(10-12-31)22-13-23-25(29-18-30-33(23)15-22)32-16-27(3,17-32)26(35)28-14-20-7-5-19(2)6-8-20/h5-9,13,15,18H,4,10-12,14,16-17H2,1-3H3,(H,28,35)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175638
PNG
(US9688680, 186)
Show SMILES COC(C)(C)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H31N7O2/c1-18-5-7-19(8-6-18)10-27-25(34)22-12-31(13-22)24-23-9-20(15-33(23)30-17-28-24)21-11-29-32(14-21)16-26(2,3)35-4/h5-9,11,14-15,17,22H,10,12-13,16H2,1-4H3,(H,27,34)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175642
PNG
(US9688680, 190)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C25H25N5O3S/c1-17-3-5-18(6-4-17)12-26-25(31)21-13-29(14-21)24-23-11-20(15-30(23)28-16-27-24)19-7-9-22(10-8-19)34(2,32)33/h3-11,15-16,21H,12-14H2,1-2H3,(H,26,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175660
PNG
(US9688680, 206)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)N2CCCC2=O)cc1
Show InChI InChI=1S/C28H28N6O2/c1-19-4-6-20(7-5-19)14-29-28(36)23-15-32(16-23)27-25-13-22(17-34(25)31-18-30-27)21-8-10-24(11-9-21)33-12-2-3-26(33)35/h4-11,13,17-18,23H,2-3,12,14-16H2,1H3,(H,29,36)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175705
PNG
(US9688680, 250)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC(C)(C)O)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H28ClN7O2/c1-16(17-4-6-21(26)7-5-17)30-24(34)20-10-31(11-20)23-22-8-18(13-33(22)29-15-27-23)19-9-28-32(12-19)14-25(2,3)35/h4-9,12-13,15-16,20,35H,10-11,14H2,1-3H3,(H,30,34)/t16-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175755
PNG
(US9688680, 300)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23+/m1/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175760
PNG
(US9688680, 305)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN5O3S/c1-3-23(18-4-8-21(27)9-5-18)30-26(33)20-13-31(14-20)25-24-12-19(15-32(24)29-16-28-25)17-6-10-22(11-7-17)36(2,34)35/h4-12,15-16,20,23H,3,13-14H2,1-2H3,(H,30,33)/t23-/m0/s1
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US Patent
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175231
PNG
(US9688680, 17)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C22H20N8O/c1-14-19(12-28(2)27-14)16-7-20-21(24-13-25-30(20)11-16)29-9-17(10-29)22(31)26-18-5-3-15(8-23)4-6-18/h3-7,11-13,17H,9-10H2,1-2H3,(H,26,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175436
PNG
(US9688680, 36)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)c(F)c1
Show InChI InChI=1S/C22H22FN7O/c1-14-3-4-15(19(23)5-14)7-24-22(31)18-10-29(11-18)21-20-6-16(12-30(20)27-13-25-21)17-8-26-28(2)9-17/h3-6,8-9,12-13,18H,7,10-11H2,1-2H3,(H,24,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175489
PNG
(US9688680, 89)
Show SMILES CC(C)n1cc(c(N)n1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C24H28N8O/c1-15(2)31-13-20(22(25)29-31)18-8-21-23(27-14-28-32(21)12-18)30-10-19(11-30)24(33)26-9-17-6-4-16(3)5-7-17/h4-8,12-15,19H,9-11H2,1-3H3,(H2,25,29)(H,26,33)
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US Patent
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%