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Patent code US9688695

Compile Data Set for Download or QSAR

Found 384 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175972
PNG
(US10047103, 5 | US9688695, 5)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C22H21N5O5S2/c1-28-14-7-17(31-11-13-12-33-20(23-13)26-3-5-30-6-4-26)15-9-19(32-18(15)8-14)16-10-27-21(24-16)34-22(25-27)29-2/h7-10,12H,3-6,11H2,1-2H3
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n/an/an/an/a 0.610n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175973
PNG
(US10047103, 6 | US9688695, 6)
Show SMILES COCCOCc1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C22H22N4O6S2/c1-27-4-5-30-11-20-23-13(12-33-20)10-31-17-6-14(28-2)7-18-15(17)8-19(32-18)16-9-26-21(24-16)34-22(25-26)29-3/h6-9,12H,4-5,10-11H2,1-3H3
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n/an/an/an/a 0.680n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175975
PNG
(US10047103, 8 | US9688695, 8)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nnc(s3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-14-8-17(31-12-20-25-26-21(33-20)13-6-4-3-5-7-13)15-10-19(32-18(15)9-14)16-11-28-22(24-16)34-23(27-28)30-2/h3-11H,12H2,1-2H3
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n/an/an/an/a 3.90n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175976
PNG
(US10047103, 9 | US9688695, 9)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cn(nn3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H18N6O4S/c1-30-16-8-19(32-13-14-11-28(27-25-14)15-6-4-3-5-7-15)17-10-21(33-20(17)9-16)18-12-29-22(24-18)34-23(26-29)31-2/h3-12H,13H2,1-2H3
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n/an/an/an/a 5.30n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175985
PNG
(US10047103, 18 | US9688695, 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N4O5S2/c1-30-16-6-4-14(5-7-16)23-26-15(13-35-23)12-33-20-8-17(31-2)9-21-18(20)10-22(34-21)19-11-29-24(27-19)36-25(28-29)32-3/h4-11,13H,12H2,1-3H3
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n/an/an/an/a 2.5n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175992
PNG
(US10047103, 25 | US9688695, 25)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3cccc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C24H17FN4O4S2/c1-30-16-7-19(32-11-15-12-34-22(26-15)13-4-3-5-14(25)6-13)17-9-21(33-20(17)8-16)18-10-29-23(27-18)35-24(28-29)31-2/h3-10,12H,11H2,1-2H3
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n/an/an/an/a 0.550n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175995
PNG
(US10047103, 75 | US9688695, 28 | US9688695, 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-15-7-18(31-11-14-12-33-21(25-14)13-3-5-24-6-4-13)16-9-20(32-19(16)8-15)17-10-28-22(26-17)34-23(27-28)30-2/h3-10,12H,11H2,1-2H3
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n/an/an/an/a 0.510n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176002
PNG
(US10047103, 35 | US9688695, 35)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(Br)n3)cc(OC)cc2o1
Show InChI InChI=1S/C18H13BrN4O4S2/c1-24-10-3-13(26-7-9-8-28-16(19)20-9)11-5-15(27-14(11)4-10)12-6-23-17(21-12)29-18(22-23)25-2/h3-6,8H,7H2,1-2H3
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n/an/an/an/a 1.30n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176004
PNG
(US10047103, 37 | US9688695, 37)
Show SMILES COC(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C26H20N4O6S2/c1-32-17-8-20(35-12-16-13-37-23(27-16)14-4-6-15(7-5-14)24(31)33-2)18-10-22(36-21(18)9-17)19-11-30-25(28-19)38-26(29-30)34-3/h4-11,13H,12H2,1-3H3
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n/an/an/an/a 0.450n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176006
PNG
(US10047103, 39 | US9688695, 39)
Show SMILES COCCN(C)C(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C29H27N5O6S2/c1-33(9-10-36-2)27(35)18-7-5-17(6-8-18)26-30-19(16-41-26)15-39-23-11-20(37-3)12-24-21(23)13-25(40-24)22-14-34-28(31-22)42-29(32-34)38-4/h5-8,11-14,16H,9-10,15H2,1-4H3
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n/an/an/an/a 0.460n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176014
PNG
(US10047103, 47 | US9688695, 47)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C28H22F3N5O5S2/c1-14-20(33-25(42-14)16-6-4-15(5-7-16)24(37)32-13-28(29,30)31)12-40-21-8-17(38-2)9-22-18(21)10-23(41-22)19-11-36-26(34-19)43-27(35-36)39-3/h4-11H,12-13H2,1-3H3,(H,32,37)
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n/an/an/an/a 0.770n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176029
PNG
(US10047103, 62 | US9688695, 62)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3cccc(OC(C)=O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O6S2/c1-14(31)35-17-6-4-5-15(7-17)24-27-16(13-37-24)12-34-21-8-18(32-2)9-22-19(21)10-23(36-22)20-11-30-25(28-20)38-26(29-30)33-3/h4-11,13H,12H2,1-3H3
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n/an/an/an/a 0.480n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176036
PNG
(US10047103, 69 | US9688695, 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(CO)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N4O5S2/c1-31-17-7-20(33-12-16-13-35-23(26-16)15-5-3-14(11-30)4-6-15)18-9-22(34-21(18)8-17)19-10-29-24(27-19)36-25(28-29)32-2/h3-10,13,30H,11-12H2,1-2H3
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n/an/an/an/a 0.230n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176039
PNG
(US10047103, 72 | US9688695, 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(N)=O)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O5S2/c1-32-16-7-19(34-11-15-12-36-23(27-15)14-5-3-13(4-6-14)22(26)31)17-9-21(35-20(17)8-16)18-10-30-24(28-18)37-25(29-30)33-2/h3-10,12H,11H2,1-2H3,(H2,26,31)
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n/an/an/an/a 0.260n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176041
PNG
(US10047103, 74 | US9688695, 74)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(C)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H19N5O4S2/c1-13-4-5-14(9-25-13)22-26-15(12-34-22)11-32-19-6-16(30-2)7-20-17(19)8-21(33-20)18-10-29-23(27-18)35-24(28-29)31-3/h4-10,12H,11H2,1-3H3
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n/an/an/an/a 0.560n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175995
PNG
(US10047103, 75 | US9688695, 28 | US9688695, 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-15-7-18(31-11-14-12-33-21(25-14)13-3-5-24-6-4-13)16-9-20(32-19(16)8-15)17-10-28-22(26-17)34-23(27-28)30-2/h3-10,12H,11H2,1-2H3
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n/an/an/an/a 0.320n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176052
PNG
(US10047103, 85 | US9688695, 85)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3Cl)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H17ClN4O4S2/c1-30-14-8-18(32-12-17-21(25)34-22(26-17)13-6-4-3-5-7-13)15-10-20(33-19(15)9-14)16-11-29-23(27-16)35-24(28-29)31-2/h3-11H,12H2,1-2H3
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n/an/an/an/a 1.10n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176054
PNG
(US10047103, 87 | US9688695, 87)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(N)sc3C)cc(OC)cc2o1
Show InChI InChI=1S/C19H17N5O4S2/c1-9-13(21-17(20)29-9)8-27-14-4-10(25-2)5-15-11(14)6-16(28-15)12-7-24-18(22-12)30-19(23-24)26-3/h4-7H,8H2,1-3H3,(H2,20,21)
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n/an/an/an/a 24n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176062
PNG
(US10047103, 95 | US9688695, 95)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)C3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H24N4O5S2/c1-13-18(25-22(34-13)14-4-6-31-7-5-14)12-32-19-8-15(29-2)9-20-16(19)10-21(33-20)17-11-28-23(26-17)35-24(27-28)30-3/h8-11,14H,4-7,12H2,1-3H3
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n/an/an/an/a 0.830n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176068
PNG
(US10047103, 101 | US9688695, 101)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCN(CC3)S(=O)(=O)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N7O6S3/c1-39-20-11-24(22-13-26(42-25(22)12-20)23-15-36-28(32-23)44-29(33-36)40-2)41-16-19-17-43-27(31-19)34-7-9-35(10-8-34)45(37,38)21-5-3-18(14-30)4-6-21/h3-6,11-13,15,17H,7-10,16H2,1-2H3
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n/an/an/an/a 0.360n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176071
PNG
(US10047103, 104 | US9688695, 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CC4(COC4)C3)cc(OC)cc2o1
Show InChI InChI=1S/C23H21N5O5S2/c1-29-14-3-17(32-7-13-8-34-20(24-13)27-9-23(10-27)11-31-12-23)15-5-19(33-18(15)4-14)16-6-28-21(25-16)35-22(26-28)30-2/h3-6,8H,7,9-12H2,1-2H3
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n/an/an/an/a 0.680n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176076
PNG
(US10047103, 109 | US9688695, 109)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3CCN(CC3)C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C28H31N5O6S2/c1-28(2,3)39-27(34)32-8-6-16(7-9-32)24-29-17(15-40-24)14-37-21-10-18(35-4)11-22-19(21)12-23(38-22)20-13-33-25(30-20)41-26(31-33)36-5/h10-13,15-16H,6-9,14H2,1-5H3
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n/an/an/an/a 0.690n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176082
PNG
(US10047103, 115 | US9688695, 115)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3CCC(F)(F)CC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H22F2N4O4S2/c1-31-15-7-18(33-11-14-12-35-21(27-14)13-3-5-24(25,26)6-4-13)16-9-20(34-19(16)8-15)17-10-30-22(28-17)36-23(29-30)32-2/h7-10,12-13H,3-6,11H2,1-2H3
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n/an/an/an/a 0.330n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176089
PNG
(US10047103, 122 | US9688695, 122)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(F)CC(C)OC(C)C3)cc(OC)cc2o1
Show InChI InChI=1S/C25H25FN4O5S2/c1-13-8-25(26,9-14(2)34-13)22-27-15(12-36-22)11-33-19-5-16(31-3)6-20-17(19)7-21(35-20)18-10-30-23(28-18)37-24(29-30)32-4/h5-7,10,12-14H,8-9,11H2,1-4H3
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n/an/an/an/a 0.720n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176097
PNG
(US10047103, 130 | US9688695, 130)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(O)CCN(CC3)C(=O)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O6S2/c1-38-20-12-23(21-14-25(41-24(21)13-20)22-15-35-28(32-22)43-29(33-35)39-2)40-16-19-17-42-27(31-19)30(37)8-10-34(11-9-30)26(36)18-6-4-3-5-7-18/h3-7,12-15,17,37H,8-11,16H2,1-2H3
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n/an/an/an/a 0.400n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176116
PNG
(US10047103, 149 | US9688695, 149)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(O)CCC(CC3)C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C29H32N4O7S2/c1-28(2,3)40-24(34)16-6-8-29(35,9-7-16)25-30-17(15-41-25)14-38-21-10-18(36-4)11-22-19(21)12-23(39-22)20-13-33-26(31-20)42-27(32-33)37-5/h10-13,15-16,35H,6-9,14H2,1-5H3
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n/an/an/an/a 4.10n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176119
PNG
(US10047103, 152 | US9688695, 152)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(O)CCC(CC3)C(=O)N(C)CC#N)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N6O6S2/c1-33(9-8-29)24(35)16-4-6-28(36,7-5-16)25-30-17(15-41-25)14-39-21-10-18(37-2)11-22-19(21)12-23(40-22)20-13-34-26(31-20)42-27(32-34)38-3/h10-13,15-16,36H,4-7,9,14H2,1-3H3
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n/an/an/an/a 0.680n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176121
PNG
(US10047103, 154 | US9688695, 154)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(CCOCC3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25ClN4O5S2/c1-35-20-11-23(21-13-25(39-24(21)12-20)22-14-34-27(32-22)41-28(33-34)36-2)38-15-19-16-40-26(31-19)29(7-9-37-10-8-29)17-3-5-18(30)6-4-17/h3-6,11-14,16H,7-10,15H2,1-2H3
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n/an/an/an/a 1.10n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176125
PNG
(US10047103, 158 | US9688695, 158)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(CCOCC3)c3cccc(OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H28N4O6S2/c1-35-20-6-4-5-18(11-20)30(7-9-38-10-8-30)27-31-19(17-41-27)16-39-24-12-21(36-2)13-25-22(24)14-26(40-25)23-15-34-28(32-23)42-29(33-34)37-3/h4-6,11-15,17H,7-10,16H2,1-3H3
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n/an/an/an/a 0.950n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176149
PNG
(US10047103, 182 | US9688695, 182)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)(C)C)cc(F)cc2o1
Show InChI InChI=1S/C29H26FN5O4S2/c1-29(2,3)34(4)26(36)17-8-6-16(7-9-17)25-31-19(15-40-25)14-38-22-10-18(30)11-23-20(22)12-24(39-23)21-13-35-27(32-21)41-28(33-35)37-5/h6-13,15H,14H2,1-5H3
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n/an/an/an/a 0.300n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176151
PNG
(US10047103, 184 | US9688695, 184)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)CC#N)cc(F)cc2o1
Show InChI InChI=1S/C27H19FN6O4S2/c1-33(8-7-29)25(35)16-5-3-15(4-6-16)24-30-18(14-39-24)13-37-21-9-17(28)10-22-19(21)11-23(38-22)20-12-34-26(31-20)40-27(32-34)36-2/h3-6,9-12,14H,8,13H2,1-2H3
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n/an/an/an/a 0.380n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176164
PNG
(US10047103, 197 | US9688695, 197)
Show SMILES COc1cc(OCc2csc(n2)C2(F)CCOCC2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C24H22F2N4O4S2/c1-13(25)21-29-30-10-17(28-23(30)36-21)20-9-16-18(7-15(31-2)8-19(16)34-20)33-11-14-12-35-22(27-14)24(26)3-5-32-6-4-24/h7-10,12-13H,3-6,11H2,1-2H3/t13-/m0/s1
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n/an/an/an/a 0.340n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176180
PNG
(US10047103, 213 | US9688695, 213)
Show SMILES COc1cc(OCc2csc(n2)C2CCOCC2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C25H24N4O4S/c1-15-3-4-24-27-20(12-29(24)28-15)23-11-19-21(9-18(30-2)10-22(19)33-23)32-13-17-14-34-25(26-17)16-5-7-31-8-6-16/h3-4,9-12,14,16H,5-8,13H2,1-2H3
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n/an/an/an/a 3.60n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176186
PNG
(US10047103, 219 | US9688695, 219)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc3OCOc3c2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C27H20N4O5S/c1-15-3-6-26-29-20(11-31(26)30-15)24-10-19-22(8-18(32-2)9-23(19)36-24)33-12-17-13-37-27(28-17)16-4-5-21-25(7-16)35-14-34-21/h3-11,13H,12,14H2,1-2H3
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n/an/an/an/a 1n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176189
PNG
(US10047103, 222 | US9688695, 222)
Show SMILES COc1cc(OCc2csc(n2)-c2cccc(O)c2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C26H20N4O4S/c1-15-6-7-25-28-21(12-30(25)29-15)24-11-20-22(9-19(32-2)10-23(20)34-24)33-13-17-14-35-26(27-17)16-4-3-5-18(31)8-16/h3-12,14,31H,13H2,1-2H3
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n/an/an/an/a 0.650n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176198
PNG
(US10047103, 231 | US9688695, 231)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(C)nc2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C26H21N5O3S/c1-15-4-6-17(11-27-15)26-28-18(14-35-26)13-33-22-8-19(32-3)9-23-20(22)10-24(34-23)21-12-31-25(29-21)7-5-16(2)30-31/h4-12,14H,13H2,1-3H3
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n/an/an/an/a 1.80n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176207
PNG
(US10047103, 240 | US9688695, 240)
Show SMILES COc1cc(OCc2csc(n2)C2(CCOCC2)c2cccc(Cl)c2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C31H27ClN4O4S/c1-19-6-7-29-34-25(16-36(29)35-19)28-15-24-26(13-23(37-2)14-27(24)40-28)39-17-22-18-41-30(33-22)31(8-10-38-11-9-31)20-4-3-5-21(32)12-20/h3-7,12-16,18H,8-11,17H2,1-2H3
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n/an/an/an/a 6.90n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176208
PNG
(US10047103, 241 | US9688695, 241)
Show SMILES COc1cc(OCc2csc(n2)C2(CCOC2)c2ccc(Cl)cc2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C30H25ClN4O4S/c1-18-3-8-28-33-24(14-35(28)34-18)27-13-23-25(11-22(36-2)12-26(23)39-27)38-15-21-16-40-29(32-21)30(9-10-37-17-30)19-4-6-20(31)7-5-19/h3-8,11-14,16H,9-10,15,17H2,1-2H3
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n/an/an/an/a 1.20n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176212
PNG
(US10047103, 245 | US9688695, 245)
Show SMILES COc1cc(OCc2csc(NCc3cccnc3)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C26H22N6O3S/c1-16-5-6-25-30-21(13-32(25)31-16)24-10-20-22(8-19(33-2)9-23(20)35-24)34-14-18-15-36-26(29-18)28-12-17-4-3-7-27-11-17/h3-11,13,15H,12,14H2,1-2H3,(H,28,29)
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n/an/an/an/a 5.5n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176213
PNG
(US10047103, 246 | US9688695, 246)
Show SMILES COCCN(CCOC)c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(C)ccc3n2)cs1
Show InChI InChI=1S/C26H29N5O5S/c1-17-5-6-25-28-21(14-31(25)29-17)24-13-20-22(11-19(34-4)12-23(20)36-24)35-15-18-16-37-26(27-18)30(7-9-32-2)8-10-33-3/h5-6,11-14,16H,7-10,15H2,1-4H3
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n/an/an/an/a 1.40n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176214
PNG
(US10047103, 247 | US9688695, 247)
Show SMILES COc1cc(OCc2csc(n2)N2CCN(CC2)c2cnccn2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C28H26N8O3S/c1-18-3-4-26-32-22(15-36(26)33-18)25-13-21-23(11-20(37-2)12-24(21)39-25)38-16-19-17-40-28(31-19)35-9-7-34(8-10-35)27-14-29-5-6-30-27/h3-6,11-15,17H,7-10,16H2,1-2H3
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n/an/an/an/a 0.420n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176215
PNG
(US10047103, 248 | US9688695, 248)
Show SMILES COc1cc(OCc2csc(Nc3cccc(c3)N(C)C)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C28H26N6O3S/c1-17-8-9-27-31-23(14-34(27)32-17)26-13-22-24(11-21(35-4)12-25(22)37-26)36-15-19-16-38-28(30-19)29-18-6-5-7-20(10-18)33(2)3/h5-14,16H,15H2,1-4H3,(H,29,30)
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n/an/an/an/a 3.10n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176184
PNG
(US10047103, 258 | US9688695, 217 | US9688695, 258)
Show SMILES COc1cc(OCc2csc(n2)N2CCSCC2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C24H23N5O3S2/c1-15-3-4-23-26-19(12-29(23)27-15)22-11-18-20(9-17(30-2)10-21(18)32-22)31-13-16-14-34-24(25-16)28-5-7-33-8-6-28/h3-4,9-12,14H,5-8,13H2,1-2H3
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n/an/an/an/a 0.810n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176235
PNG
(US10047103, 268 | US9688695, 268)
Show SMILES COc1cc(OCc2csc(n2)N2CCN(CC2)c2cccc(Cl)c2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C30H27ClN6O3S/c1-19-6-7-29-33-25(16-37(29)34-19)28-15-24-26(13-23(38-2)14-27(24)40-28)39-17-21-18-41-30(32-21)36-10-8-35(9-11-36)22-5-3-4-20(31)12-22/h3-7,12-16,18H,8-11,17H2,1-2H3
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n/an/an/an/a 1.70n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176247
PNG
(US10047103, 280 | US9688695, 280)
Show SMILES COc1cc(OCc2csc(n2)N(C)C(C)C)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C24H25N5O3S/c1-14(2)28(4)24-25-16(13-33-24)12-31-20-8-17(30-5)9-21-18(20)10-22(32-21)19-11-29-23(26-19)7-6-15(3)27-29/h6-11,13-14H,12H2,1-5H3
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n/an/an/an/a 6.20n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176278
PNG
(US10047103, 311 | US9688695, 311)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)CCC#N)cc(OC)cc2o1
Show InChI InChI=1S/C29H24N6O5S2/c1-34(10-4-9-30)27(36)18-7-5-17(6-8-18)26-31-19(16-41-26)15-39-23-11-20(37-2)12-24-21(23)13-25(40-24)22-14-35-28(32-22)42-29(33-35)38-3/h5-8,11-14,16H,4,10,15H2,1-3H3
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n/an/an/an/a 0.650n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176284
PNG
(US10047103, 317 | US9688695, 317)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N3C(C)CCC3C)cc(OC)cc2o1
Show InChI InChI=1S/C31H29N5O5S2/c1-17-5-6-18(2)36(17)29(37)20-9-7-19(8-10-20)28-32-21(16-42-28)15-40-25-11-22(38-3)12-26-23(25)13-27(41-26)24-14-35-30(33-24)43-31(34-35)39-4/h7-14,16-18H,5-6,15H2,1-4H3
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n/an/an/an/a 1.60n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176082
PNG
(US10047103, 115 | US9688695, 115)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3CCC(F)(F)CC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H22F2N4O4S2/c1-31-15-7-18(33-11-14-12-35-21(27-14)13-3-5-24(25,26)6-4-13)16-9-20(34-19(16)8-15)17-10-30-22(28-17)36-23(29-30)32-2/h7-10,12-13H,3-6,11H2,1-2H3
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n/an/an/an/a 28n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176168
PNG
(US10047103, 201 | US9688695, 201)
Show SMILES COc1cc(OCc2csc(n2)-c2ccccc2)c2nc(oc2c1)-c1cn2nc(SC)sc2n1
Show InChI InChI=1S/C23H17N5O3S3/c1-29-15-8-17(30-11-14-12-33-21(24-14)13-6-4-3-5-7-13)19-18(9-15)31-20(26-19)16-10-28-22(25-16)34-23(27-28)32-2/h3-10,12H,11H2,1-2H3
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n/an/an/an/a 156n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176233
PNG
(US10047103, 266 | US9688695, 266)
Show SMILES COc1cc(OCc2csc(Nc3cc(C)ccc3F)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C27H22FN5O3S/c1-15-4-6-20(28)21(8-15)31-27-29-17(14-37-27)13-35-23-9-18(34-3)10-24-19(23)11-25(36-24)22-12-33-26(30-22)7-5-16(2)32-33/h4-12,14H,13H2,1-3H3,(H,29,31)
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n/an/an/an/a>3.00E+3n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...


US Patent US9688695 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%