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Patent code US9688696

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176294
PNG
(US9688696, 9)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c1-15(2)33-23-20(14-27-33)28-22(30-23)16-6-8-17(9-7-16)31-10-12-32(13-11-31)24(34)29-21-18(25)4-3-5-19(21)26/h3-9,14-15H,10-13H2,1-2H3,(H,28,30)(H,29,34)
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n/an/a 6.46n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176286
PNG
(US9688696, 1)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C29H27Cl2N7O/c1-19-5-7-20(8-6-19)18-38-28-25(17-32-38)33-27(35-28)21-9-11-22(12-10-21)36-13-15-37(16-14-36)29(39)34-26-23(30)3-2-4-24(26)31/h2-12,17H,13-16,18H2,1H3,(H,33,35)(H,34,39)
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n/an/a 8.91n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176337
PNG
(US9688696, 53)
Show SMILES Clc1cc(cc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc2n(ncc2[nH]1)C1CCCC1)N1CCCC1
Show InChI InChI=1S/C30H34Cl2N8O/c31-24-17-23(37-11-3-4-12-37)18-25(32)27(24)35-30(41)39-15-13-38(14-16-39)21-9-7-20(8-10-21)28-34-26-19-33-40(29(26)36-28)22-5-1-2-6-22/h7-10,17-19,22H,1-6,11-16H2,(H,34,36)(H,35,41)
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n/an/a 12n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176338
PNG
(US9688696, 54)
Show SMILES Clc1cc(CN2CCCC2)cc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc2cnn(-c3ccccc3)c2[nH]1
Show InChI InChI=1S/C32H32Cl2N8O/c33-26-18-22(21-39-12-4-5-13-39)19-27(34)29(26)37-32(43)41-16-14-40(15-17-41)24-10-8-23(9-11-24)30-36-28-20-35-42(31(28)38-30)25-6-2-1-3-7-25/h1-3,6-11,18-20H,4-5,12-17,21H2,(H,36,38)(H,37,43)
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n/an/a 13n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176339
PNG
(US9688696, 55)
Show SMILES CC(c1ccccc1)n1ncc2[nH]c(nc12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cc(cc1Cl)N1CCCC1
Show InChI InChI=1S/C33H34Cl2N8O/c1-22(23-7-3-2-4-8-23)43-32-29(21-36-43)37-31(39-32)24-9-11-25(12-10-24)41-15-17-42(18-16-41)33(44)38-30-27(34)19-26(20-28(30)35)40-13-5-6-14-40/h2-4,7-12,19-22H,5-6,13-18H2,1H3,(H,37,39)(H,38,44)
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n/an/a 15n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176340
PNG
(US9688696, 56)
Show SMILES Clc1cc(CN2CCCC2)cc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc2cnn(Cc3ccccc3)c2[nH]1
Show InChI InChI=1S/C33H34Cl2N8O/c34-27-18-24(21-40-12-4-5-13-40)19-28(35)30(27)38-33(44)42-16-14-41(15-17-42)26-10-8-25(9-11-26)31-37-29-20-36-43(32(29)39-31)22-23-6-2-1-3-7-23/h1-3,6-11,18-20H,4-5,12-17,21-22H2,(H,37,39)(H,38,44)
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n/an/a 17n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176341
PNG
(US9688696, 57)
Show SMILES OCc1cc(Cl)c(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2ccn(CCc3ccccc3)n2)c(Cl)c1
Show InChI InChI=1S/C29H29Cl2N5O2/c30-25-18-22(20-37)19-26(31)28(25)32-29(38)35-16-14-34(15-17-35)24-8-6-23(7-9-24)27-11-13-36(33-27)12-10-21-4-2-1-3-5-21/h1-9,11,13,18-19,37H,10,12,14-17,20H2,(H,32,38)
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n/an/a 23n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176313
PNG
(US9688696, 28)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ncn(CCc2ccccc2)n1
Show InChI InChI=1S/C27H26Cl2N6O/c28-23-7-4-8-24(29)25(23)31-27(36)34-17-15-33(16-18-34)22-11-9-21(10-12-22)26-30-19-35(32-26)14-13-20-5-2-1-3-6-20/h1-12,19H,13-18H2,(H,31,36)
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n/an/a 25n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176293
PNG
(US9688696, 8)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H26Cl2N6O/c1-16(2)33-25-22(15-28-33)29-24(30-25)17-6-8-18(9-7-17)31-10-12-32(13-11-31)23(34)14-19-20(26)4-3-5-21(19)27/h3-9,15-16H,10-14H2,1-2H3,(H,29,30)
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n/an/a 30n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176314
PNG
(US9688696, 29)
Show SMILES COc1ccc(Cn2cnc(n2)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C27H26Cl2N6O2/c1-37-22-11-5-19(6-12-22)17-35-18-30-26(32-35)20-7-9-21(10-8-20)33-13-15-34(16-14-33)27(36)31-25-23(28)3-2-4-24(25)29/h2-12,18H,13-17H2,1H3,(H,31,36)
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n/an/a 31n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176315
PNG
(US9688696, 30)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ncn(CCCc2ccccc2)n1
Show InChI InChI=1S/C28H28Cl2N6O/c29-24-9-4-10-25(30)26(24)32-28(37)35-18-16-34(17-19-35)23-13-11-22(12-14-23)27-31-20-36(33-27)15-5-8-21-6-2-1-3-7-21/h1-4,6-7,9-14,20H,5,8,15-19H2,(H,32,37)
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n/an/a 32n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176316
PNG
(US9688696, 31)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nnc(CCc2ccccc2)o1
Show InChI InChI=1S/C27H25Cl2N5O2/c28-22-7-4-8-23(29)25(22)30-27(35)34-17-15-33(16-18-34)21-12-10-20(11-13-21)26-32-31-24(36-26)14-9-19-5-2-1-3-6-19/h1-8,10-13H,9,14-18H2,(H,30,35)
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n/an/a 41n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176342
PNG
(US9688696, 58)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cc(CN2CCCC2)cc1Cl
Show InChI InChI=1S/C29H34Cl2N8O/c1-19(2)39-28-25(17-32-39)33-27(35-28)21-5-7-22(8-6-21)37-11-13-38(14-12-37)29(40)34-26-23(30)15-20(16-24(26)31)18-36-9-3-4-10-36/h5-8,15-17,19H,3-4,9-14,18H2,1-2H3,(H,33,35)(H,34,40)
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n/an/a 47n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176343
PNG
(US9688696, 59)
Show SMILES OCc1cc(Cl)c(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2ccn(CCCc3ccccc3)n2)c(Cl)c1
Show InChI InChI=1S/C30H31Cl2N5O2/c31-26-19-23(21-38)20-27(32)29(26)33-30(39)36-17-15-35(16-18-36)25-10-8-24(9-11-25)28-12-14-37(34-28)13-4-7-22-5-2-1-3-6-22/h1-3,5-6,8-12,14,19-20,38H,4,7,13,15-18,21H2,(H,33,39)
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n/an/a 74n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176350
PNG
(US9688696, 66)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H26F3N7O/c1-16(2)35-23-21(15-29-35)30-22(32-23)17-7-9-18(10-8-17)33-11-13-34(14-12-33)24(36)31-20-6-4-3-5-19(20)25(26,27)28/h3-10,15-16H,11-14H2,1-2H3,(H,30,32)(H,31,36)
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n/an/a 79n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176317
PNG
(US9688696, 32)
Show SMILES CCCCn1cnc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H26Cl2N6O/c1-2-3-11-31-16-26-22(28-31)17-7-9-18(10-8-17)29-12-14-30(15-13-29)23(32)27-21-19(24)5-4-6-20(21)25/h4-10,16H,2-3,11-15H2,1H3,(H,27,32)
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n/an/a 83n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176351
PNG
(US9688696, 67)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C24H26ClN7O/c1-16(2)32-23-21(15-26-32)27-22(29-23)17-7-9-18(10-8-17)30-11-13-31(14-12-30)24(33)28-20-6-4-3-5-19(20)25/h3-10,15-16H,11-14H2,1-2H3,(H,27,29)(H,28,33)
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n/an/a 85n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176344
PNG
(US9688696, 60)
Show SMILES Clc1cc(CN2CCCC2)cc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ncn(CCc2ccccc2)n1
Show InChI InChI=1S/C32H35Cl2N7O/c33-28-20-25(22-38-13-4-5-14-38)21-29(34)30(28)36-32(42)40-18-16-39(17-19-40)27-10-8-26(9-11-27)31-35-23-41(37-31)15-12-24-6-2-1-3-7-24/h1-3,6-11,20-21,23H,4-5,12-19,22H2,(H,36,42)
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n/an/a 98n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176318
PNG
(US9688696, 33)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc(CCCc2ccccc2)no1
Show InChI InChI=1S/C28H27Cl2N5O2/c29-23-9-5-10-24(30)26(23)32-28(36)35-18-16-34(17-19-35)22-14-12-21(13-15-22)27-31-25(33-37-27)11-4-8-20-6-2-1-3-7-20/h1-3,5-7,9-10,12-15H,4,8,11,16-19H2,(H,32,36)
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n/an/a 105n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176287
PNG
(US9688696, 2)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccn(CCc2ccccc2)n1
Show InChI InChI=1S/C28H27Cl2N5O/c29-24-7-4-8-25(30)27(24)31-28(36)34-19-17-33(18-20-34)23-11-9-22(10-12-23)26-14-16-35(32-26)15-13-21-5-2-1-3-6-21/h1-12,14,16H,13,15,17-20H2,(H,31,36)
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n/an/a 110n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176312
PNG
(US9688696, 27)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Cc2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C30H28Cl2N6O/c1-20-5-7-21(8-6-20)19-38-30-27(18-33-38)34-29(35-30)22-9-11-23(12-10-22)36-13-15-37(16-14-36)28(39)17-24-25(31)3-2-4-26(24)32/h2-12,18H,13-17,19H2,1H3,(H,34,35)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176352
PNG
(US9688696, 68)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C30H28F3N7O/c1-20-6-8-21(9-7-20)19-40-28-26(18-34-40)35-27(37-28)22-10-12-23(13-11-22)38-14-16-39(17-15-38)29(41)36-25-5-3-2-4-24(25)30(31,32)33/h2-13,18H,14-17,19H2,1H3,(H,35,37)(H,36,41)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176319
PNG
(US9688696, 34)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc(Cc2ccccc2)no1
Show InChI InChI=1S/C26H23Cl2N5O2/c27-21-7-4-8-22(28)24(21)30-26(34)33-15-13-32(14-16-33)20-11-9-19(10-12-20)25-29-23(31-35-25)17-18-5-2-1-3-6-18/h1-12H,13-17H2,(H,30,34)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176320
PNG
(US9688696, 35)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C26H23Cl2N5O2/c27-21-7-4-8-22(28)24(21)29-26(34)33-15-13-32(14-16-33)20-11-9-19(10-12-20)25-31-30-23(35-25)17-18-5-2-1-3-6-18/h1-12H,13-17H2,(H,29,34)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176321
PNG
(US9688696, 36)
Show SMILES CCCCc1nnc(o1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H25Cl2N5O2/c1-2-3-7-20-27-28-22(32-20)16-8-10-17(11-9-16)29-12-14-30(15-13-29)23(31)26-21-18(24)5-4-6-19(21)25/h4-6,8-11H,2-3,7,12-15H2,1H3,(H,26,31)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176345
PNG
(US9688696, 61)
Show SMILES Oc1cc(Cl)c(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2ccn(CCc3ccccc3)n2)c(Cl)c1
Show InChI InChI=1S/C28H27Cl2N5O2/c29-24-18-23(36)19-25(30)27(24)31-28(37)34-16-14-33(15-17-34)22-8-6-21(7-9-22)26-11-13-35(32-26)12-10-20-4-2-1-3-5-20/h1-9,11,13,18-19,36H,10,12,14-17H2,(H,31,37)
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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176353
PNG
(US9688696, 69)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c1-15(2)33-23-21(14-27-33)28-22(30-23)16-3-6-18(7-4-16)31-9-11-32(12-10-31)24(34)29-20-8-5-17(25)13-19(20)26/h3-8,13-15H,9-12H2,1-2H3,(H,28,30)(H,29,34)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176322
PNG
(US9688696, 37)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc(no1)-c1ccccc1
Show InChI InChI=1S/C25H21Cl2N5O2/c26-20-7-4-8-21(27)22(20)28-25(33)32-15-13-31(14-16-32)19-11-9-18(10-12-19)24-29-23(30-34-24)17-5-2-1-3-6-17/h1-12H,13-16H2,(H,28,33)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176354
PNG
(US9688696, 70)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccccc2Cl)cc1
Show InChI InChI=1S/C29H28ClN7O/c1-20-6-8-21(9-7-20)19-37-28-26(18-31-37)32-27(34-28)22-10-12-23(13-11-22)35-14-16-36(17-15-35)29(38)33-25-5-3-2-4-24(25)30/h2-13,18H,14-17,19H2,1H3,(H,32,34)(H,33,38)
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US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176323
PNG
(US9688696, 38)
Show SMILES CC(C)(C)c1nnc(o1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H25Cl2N5O2/c1-23(2,3)21-28-27-20(32-21)15-7-9-16(10-8-15)29-11-13-30(14-12-29)22(31)26-19-17(24)5-4-6-18(19)25/h4-10H,11-14H2,1-3H3,(H,26,31)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176291
PNG
(US9688696, 6)
Show SMILES CC(c1ccccc1)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C27H26Cl2N6O2/c1-19(20-6-3-2-4-7-20)35-27(37)34(18-30-35)22-12-10-21(11-13-22)32-14-16-33(17-15-32)26(36)31-25-23(28)8-5-9-24(25)29/h2-13,18-19H,14-17H2,1H3,(H,31,36)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176295
PNG
(US9688696, 10)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccn(Cc2ccccc2)n1
Show InChI InChI=1S/C27H25Cl2N5O/c28-23-7-4-8-24(29)26(23)30-27(35)33-17-15-32(16-18-33)22-11-9-21(10-12-22)25-13-14-34(31-25)19-20-5-2-1-3-6-20/h1-14H,15-19H2,(H,30,35)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176346
PNG
(US9688696, 62)
Show SMILES Oc1cc(Cl)c(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2ccn(CCCc3ccccc3)n2)c(Cl)c1
Show InChI InChI=1S/C29H29Cl2N5O2/c30-25-19-24(37)20-26(31)28(25)32-29(38)35-17-15-34(16-18-35)23-10-8-22(9-11-23)27-12-14-36(33-27)13-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-12,14,19-20,37H,4,7,13,15-18H2,(H,32,38)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176324
PNG
(US9688696, 39)
Show SMILES CC(C)(C)c1noc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H25Cl2N5O2/c1-23(2,3)21-27-20(32-28-21)15-7-9-16(10-8-15)29-11-13-30(14-12-29)22(31)26-19-17(24)5-4-6-18(19)25/h4-10H,11-14H2,1-3H3,(H,26,31)
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Janssen Pharmaceutica N.V.

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Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176325
PNG
(US9688696, 40)
Show SMILES CC(C)(C)n1cnc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H26Cl2N6O/c1-23(2,3)31-15-26-21(28-31)16-7-9-17(10-8-16)29-11-13-30(14-12-29)22(32)27-20-18(24)5-4-6-19(20)25/h4-10,15H,11-14H2,1-3H3,(H,27,32)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176289
PNG
(US9688696, 4)
Show SMILES CCCCn1ncnc1-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H26Cl2N6O/c1-2-3-11-31-22(26-16-27-31)17-7-9-18(10-8-17)29-12-14-30(15-13-29)23(32)28-21-19(24)5-4-6-20(21)25/h4-10,16H,2-3,11-15H2,1H3,(H,28,32)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176309
PNG
(US9688696, 24)
Show SMILES CCC(C(O)c1ccc(Cl)cc1)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C29H29Cl3N6O3/c1-2-25(27(39)19-6-8-20(30)9-7-19)38-29(41)37(18-33-38)22-12-10-21(11-13-22)35-14-16-36(17-15-35)28(40)34-26-23(31)4-3-5-24(26)32/h3-13,18,25,27,39H,2,14-17H2,1H3,(H,34,40)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176288
PNG
(US9688696, 3)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccnc(NC2CCCCC2)n1
Show InChI InChI=1S/C27H30Cl2N6O/c28-22-7-4-8-23(29)25(22)33-27(36)35-17-15-34(16-18-35)21-11-9-19(10-12-21)24-13-14-30-26(32-24)31-20-5-2-1-3-6-20/h4,7-14,20H,1-3,5-6,15-18H2,(H,33,36)(H,30,31,32)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM181674
PNG
(US9688696, 41)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccn(CCCc2ccccc2)n1
Show InChI InChI=1S/C29H29Cl2N5O/c30-25-9-4-10-26(31)28(25)32-29(37)35-20-18-34(19-21-35)24-13-11-23(12-14-24)27-15-17-36(33-27)16-5-8-22-6-2-1-3-7-22/h1-4,6-7,9-15,17H,5,8,16,18-21H2,(H,32,37)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176290
PNG
(US9688696, 5)
Show SMILES CCC(C(=O)c1ccc(Br)cc1)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C29H27BrCl2N6O3/c1-2-25(27(39)19-6-8-20(30)9-7-19)38-29(41)37(18-33-38)22-12-10-21(11-13-22)35-14-16-36(17-15-35)28(40)34-26-23(31)4-3-5-24(26)32/h3-13,18,25H,2,14-17H2,1H3,(H,34,40)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176310
PNG
(US9688696, 25)
Show SMILES CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C23H26Cl2N6O2/c1-3-16(2)31-23(33)30(15-26-31)18-9-7-17(8-10-18)28-11-13-29(14-12-28)22(32)27-21-19(24)5-4-6-20(21)25/h4-10,15-16H,3,11-14H2,1-2H3,(H,27,32)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176327
PNG
(US9688696, 42)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ncnn1
Show InChI InChI=1S/C19H17Cl2N6O/c20-15-2-1-3-16(21)17(15)24-19(28)27-10-8-26(9-11-27)14-6-4-13(5-7-14)18-22-12-23-25-18/h1-7,12H,8-11H2,(H,24,28)
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n/an/a 741n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176328
PNG
(US9688696, 43)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1cn2ccsc2n1
Show InChI InChI=1S/C22H19Cl2N5OS/c23-17-2-1-3-18(24)20(17)26-21(30)28-10-8-27(9-11-28)16-6-4-15(5-7-16)19-14-29-12-13-31-22(29)25-19/h1-7,12-14H,8-11H2,(H,26,30)
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n/an/a 759n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176347
PNG
(US9688696, 63)
Show SMILES COC(=O)c1cc(Cl)c(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2ccn(CCc3ccccc3)n2)c(Cl)c1
Show InChI InChI=1S/C30H29Cl2N5O3/c1-40-29(38)23-19-25(31)28(26(32)20-23)33-30(39)36-17-15-35(16-18-36)24-9-7-22(8-10-24)27-12-14-37(34-27)13-11-21-5-3-2-4-6-21/h2-10,12,14,19-20H,11,13,15-18H2,1H3,(H,33,39)
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n/an/a 759n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176355
PNG
(US9688696, 71)
Show SMILES Cc1ccc(cc1)-c1nc([nH]o1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C26H25ClN5O2/c1-18-6-8-20(9-7-18)25-29-24(30-34-25)19-10-12-21(13-11-19)31-14-16-32(17-15-31)26(33)28-23-5-3-2-4-22(23)27/h2-13,30H,14-17H2,1H3,(H,28,33)
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n/an/a 794n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176356
PNG
(US9688696, 72)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C28H29N7O/c1-19(2)35-27-25(18-29-35)30-26(32-27)21-10-12-22(13-11-21)33-14-16-34(17-15-33)28(36)31-24-9-5-7-20-6-3-4-8-23(20)24/h3-13,18-19H,14-17H2,1-2H3,(H,30,32)(H,31,36)
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n/an/a 832n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176357
PNG
(US9688696, 73)
Show SMILES FC(F)(F)c1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CCCCC1
Show InChI InChI=1S/C26H28F3N5O2/c27-26(28,29)21-8-4-5-9-22(21)30-25(35)34-16-14-33(15-17-34)20-12-10-18(11-13-20)23-31-24(36-32-23)19-6-2-1-3-7-19/h4-5,8-13,19H,1-3,6-7,14-17H2,(H,30,35)
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n/an/a 912n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176329
PNG
(US9688696, 44)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCC(CC1)c1ccc(cc1)-n1cnn(CCCc2ccccc2)c1=O
Show InChI InChI=1S/C29H29Cl2N5O2/c30-25-9-4-10-26(31)27(25)33-28(37)34-18-15-23(16-19-34)22-11-13-24(14-12-22)35-20-32-36(29(35)38)17-5-8-21-6-2-1-3-7-21/h1-4,6-7,9-14,20,23H,5,8,15-19H2,(H,33,37)
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n/an/a 933n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176330
PNG
(US9688696, 45)
Show SMILES COc1ccc(Cn2ncnc2-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C27H26Cl2N6O2/c1-37-22-11-5-19(6-12-22)17-35-26(30-18-31-35)20-7-9-21(10-8-20)33-13-15-34(16-14-33)27(36)32-25-23(28)3-2-4-24(25)29/h2-12,18H,13-17H2,1H3,(H,32,36)
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n/an/a 933n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176358
PNG
(US9688696, 74)
Show SMILES Cc1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2noc(n2)C2CC2)c(Cl)c1
Show InChI InChI=1S/C23H24ClN5O2/c1-15-2-9-20(19(24)14-15)25-23(30)29-12-10-28(11-13-29)18-7-5-16(6-8-18)21-26-22(31-27-21)17-3-4-17/h2,5-9,14,17H,3-4,10-13H2,1H3,(H,25,30)
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n/an/a 955n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176307
PNG
(US9688696, 22)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ncnn1Cc1ccccc1
Show InChI InChI=1S/C26H24Cl2N6O/c27-22-7-4-8-23(28)24(22)31-26(35)33-15-13-32(14-16-33)21-11-9-20(10-12-21)25-29-18-30-34(25)17-19-5-2-1-3-6-19/h1-12,18H,13-17H2,(H,31,35)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176304
PNG
(US9688696, 19)
Show SMILES CC(C)CCNc1nccc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C27H31Cl2N5O/c1-19(2)10-12-30-27-31-13-11-25(32-27)20-6-8-21(9-7-20)33-14-16-34(17-15-33)26(35)18-22-23(28)4-3-5-24(22)29/h3-9,11,13,19H,10,12,14-18H2,1-2H3,(H,30,31,32)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176359
PNG
(US9688696, 75)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C29H27Cl2N7O/c1-19-2-4-20(5-3-19)18-38-28-26(17-32-38)33-27(35-28)21-6-9-23(10-7-21)36-12-14-37(15-13-36)29(39)34-25-11-8-22(30)16-24(25)31/h2-11,16-17H,12-15,18H2,1H3,(H,33,35)(H,34,39)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176331
PNG
(US9688696, 46)
Show SMILES COc1ccc(Cn2ncn(-c3ccc(cc3)C3CCN(CC3)C(=O)Nc3c(Cl)cccc3Cl)c2=O)cc1
Show InChI InChI=1S/C28H27Cl2N5O3/c1-38-23-11-5-19(6-12-23)17-35-28(37)34(18-31-35)22-9-7-20(8-10-22)21-13-15-33(16-14-21)27(36)32-26-24(29)3-2-4-25(26)30/h2-12,18,21H,13-17H2,1H3,(H,32,36)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176308
PNG
(US9688696, 23)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1[nH]cnn1CCc1ccccc1
Show InChI InChI=1S/C27H26Cl2N6O/c28-23-7-4-8-24(29)25(23)32-27(36)34-17-15-33(16-18-34)22-11-9-21(10-12-22)26-30-19-31-35(26)14-13-20-5-2-1-3-6-20/h1-12,19H,13-18H2,(H,32,36)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176348
PNG
(US9688696, 64)
Show SMILES Clc1cc(CN2CCCC2)cc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1cn2ccsc2n1
Show InChI InChI=1S/C27H28Cl2N6OS/c28-22-15-19(17-32-7-1-2-8-32)16-23(29)25(22)31-26(36)34-11-9-33(10-12-34)21-5-3-20(4-6-21)24-18-35-13-14-37-27(35)30-24/h3-6,13-16,18H,1-2,7-12,17H2,(H,31,36)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176305
PNG
(US9688696, 20)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccnc(NCc2ccccc2)n1
Show InChI InChI=1S/C28H26Cl2N6O/c29-23-7-4-8-24(30)26(23)34-28(37)36-17-15-35(16-18-36)22-11-9-21(10-12-22)25-13-14-31-27(33-25)32-19-20-5-2-1-3-6-20/h1-14H,15-19H2,(H,34,37)(H,31,32,33)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176360
PNG
(US9688696, 76)
Show SMILES Clc1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CCCCC1
Show InChI InChI=1S/C25H28ClN5O2/c26-21-8-4-5-9-22(21)27-25(32)31-16-14-30(15-17-31)20-12-10-18(11-13-20)23-28-24(33-29-23)19-6-2-1-3-7-19/h4-5,8-13,19H,1-3,6-7,14-17H2,(H,27,32)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176361
PNG
(US9688696, 77)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2cccc3ccccc23)cc1
Show InChI InChI=1S/C33H31N7O/c1-23-9-11-24(12-10-23)22-40-32-30(21-34-40)35-31(37-32)26-13-15-27(16-14-26)38-17-19-39(20-18-38)33(41)36-29-8-4-6-25-5-2-3-7-28(25)29/h2-16,21H,17-20,22H2,1H3,(H,35,37)(H,36,41)
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n/an/a 1.38E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176349
PNG
(US9688696, 65)
Show SMILES COC(=O)c1cc(Cl)c(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2ccn(CCCc3ccccc3)n2)c(Cl)c1
Show InChI InChI=1S/C31H31Cl2N5O3/c1-41-30(39)24-20-26(32)29(27(33)21-24)34-31(40)37-18-16-36(17-19-37)25-11-9-23(10-12-25)28-13-15-38(35-28)14-5-8-22-6-3-2-4-7-22/h2-4,6-7,9-13,15,20-21H,5,8,14,16-19H2,1H3,(H,34,40)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176362
PNG
(US9688696, 78)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc(cc1)N(C)C
Show InChI InChI=1S/C26H32N8O/c1-18(2)34-25-23(17-27-34)29-24(30-25)19-5-9-22(10-6-19)32-13-15-33(16-14-32)26(35)28-20-7-11-21(12-8-20)31(3)4/h5-12,17-18H,13-16H2,1-4H3,(H,28,35)(H,29,30)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176332
PNG
(US9688696, 47)
Show SMILES CC(C)n1ncnc1-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H24Cl2N6O/c1-15(2)30-21(25-14-26-30)16-6-8-17(9-7-16)28-10-12-29(13-11-28)22(31)27-20-18(23)4-3-5-19(20)24/h3-9,14-15H,10-13H2,1-2H3,(H,27,31)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176333
PNG
(US9688696, 48)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCC(CC1)c1ccc(cc1)-n1cnn(CCc2ccccc2)c1=O
Show InChI InChI=1S/C28H27Cl2N5O2/c29-24-7-4-8-25(30)26(24)32-27(36)33-16-14-22(15-17-33)21-9-11-23(12-10-21)34-19-31-35(28(34)37)18-13-20-5-2-1-3-6-20/h1-12,19,22H,13-18H2,(H,32,36)
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n/an/a 1.74E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176292
PNG
(BDBM176311 | US9688696, 7)
Show SMILES CC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C22H24Cl2N6O2/c1-15(2)30-22(32)29(14-25-30)17-8-6-16(7-9-17)27-10-12-28(13-11-27)21(31)26-20-18(23)4-3-5-19(20)24/h3-9,14-15H,10-13H2,1-2H3,(H,26,31)
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n/an/a 1.82E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176363
PNG
(US9688696, 79)
Show SMILES CN(C)c1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2nc3cnn(Cc4ccc(C)cc4)c3[nH]2)cc1
Show InChI InChI=1S/C31H34N8O/c1-22-4-6-23(7-5-22)21-39-30-28(20-32-39)34-29(35-30)24-8-12-27(13-9-24)37-16-18-38(19-17-37)31(40)33-25-10-14-26(15-11-25)36(2)3/h4-15,20H,16-19,21H2,1-3H3,(H,33,40)(H,34,35)
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n/an/a 1.82E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176334
PNG
(US9688696, 49)
Show SMILES Cc1nnc(o1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H19Cl2N5O2/c1-13-24-25-19(29-13)14-5-7-15(8-6-14)26-9-11-27(12-10-26)20(28)23-18-16(21)3-2-4-17(18)22/h2-8H,9-12H2,1H3,(H,23,28)
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n/an/a 1.86E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176296
PNG
(US9688696, 11)
Show SMILES Clc1cccc(Cl)c1Cc1nccc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C28H23Cl4N5O/c29-21-3-1-4-22(30)20(21)17-26-33-12-11-25(34-26)18-7-9-19(10-8-18)36-13-15-37(16-14-36)28(38)35-27-23(31)5-2-6-24(27)32/h1-12H,13-17H2,(H,35,38)
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n/an/a 1.95E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176335
PNG
(US9688696, 50)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-n1cnn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C26H24Cl2N6O2/c27-22-7-4-8-23(28)24(22)30-25(35)32-15-13-31(14-16-32)20-9-11-21(12-10-20)33-18-29-34(26(33)36)17-19-5-2-1-3-6-19/h1-12,18H,13-17H2,(H,30,35)
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n/an/a 1.95E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176364
PNG
(US9688696, 80)
Show SMILES Brc1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CCC1
Show InChI InChI=1S/C23H24BrN5O2/c24-19-6-1-2-7-20(19)25-23(30)29-14-12-28(13-15-29)18-10-8-16(9-11-18)21-26-22(31-27-21)17-4-3-5-17/h1-2,6-11,17H,3-5,12-15H2,(H,25,30)
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n/an/a 2.04E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176292
PNG
(BDBM176311 | US9688696, 7)
Show SMILES CC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C22H24Cl2N6O2/c1-15(2)30-22(32)29(14-25-30)17-8-6-16(7-9-17)27-10-12-28(13-11-27)21(31)26-20-18(23)4-3-5-19(20)24/h3-9,14-15H,10-13H2,1-2H3,(H,26,31)
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n/an/a 2.45E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176365
PNG
(US9688696, 81)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C25H29N7O/c1-17(2)32-24-22(16-26-32)28-23(29-24)19-6-10-21(11-7-19)30-12-14-31(15-13-30)25(33)27-20-8-4-18(3)5-9-20/h4-11,16-17H,12-15H2,1-3H3,(H,27,33)(H,28,29)
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n/an/a 2.63E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176297
PNG
(US9688696, 12)
Show SMILES CCCCCc1nccc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H29Cl2N5O/c1-2-3-4-8-24-29-14-13-23(30-24)19-9-11-20(12-10-19)32-15-17-33(18-16-32)26(34)31-25-21(27)6-5-7-22(25)28/h5-7,9-14H,2-4,8,15-18H2,1H3,(H,31,34)
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n/an/a 2.82E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176366
PNG
(US9688696, 82)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2nc3cnn(C(C)C)c3[nH]2)cc1
Show InChI InChI=1S/C25H29N7O2/c1-17(2)32-24-22(16-26-32)28-23(29-24)18-4-8-20(9-5-18)30-12-14-31(15-13-30)25(33)27-19-6-10-21(34-3)11-7-19/h4-11,16-17H,12-15H2,1-3H3,(H,27,33)(H,28,29)
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n/an/a 2.88E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176336
PNG
(US9688696, 51)
Show SMILES CCN(CC)CCCc1noc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H32Cl2N6O2/c1-3-32(4-2)14-6-9-23-29-25(36-31-23)19-10-12-20(13-11-19)33-15-17-34(18-16-33)26(35)30-24-21(27)7-5-8-22(24)28/h5,7-8,10-13H,3-4,6,9,14-18H2,1-2H3,(H,30,35)
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n/an/a 3.02E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176367
PNG
(US9688696, 83)
Show SMILES COc1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc2cnn(Cc3ccc(C)cc3)c2[nH]1
Show InChI InChI=1S/C30H31N7O2/c1-21-7-9-22(10-8-21)20-37-29-26(19-31-37)32-28(34-29)23-11-13-24(14-12-23)35-15-17-36(18-16-35)30(38)33-25-5-3-4-6-27(25)39-2/h3-14,19H,15-18,20H2,1-2H3,(H,32,34)(H,33,38)
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n/an/a 3.09E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176369
PNG
(US9688696, 85)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H29N7O/c1-17(2)32-24-22(16-26-32)28-23(29-24)19-7-9-21(10-8-19)30-11-13-31(14-12-30)25(33)27-20-6-4-5-18(3)15-20/h4-10,15-17H,11-14H2,1-3H3,(H,27,33)(H,28,29)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176368
PNG
(US9688696, 84)
Show SMILES COc1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1nc2cnn(C(C)C)c2[nH]1
Show InChI InChI=1S/C25H29N7O2/c1-17(2)32-24-21(16-26-32)27-23(29-24)18-8-10-19(11-9-18)30-12-14-31(15-13-30)25(33)28-20-6-4-5-7-22(20)34-3/h4-11,16-17H,12-15H2,1-3H3,(H,27,29)(H,28,33)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176370
PNG
(US9688696, 86)
Show SMILES CSc1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2nc3cnn(C(C)C)c3[nH]2)cc1
Show InChI InChI=1S/C25H29N7OS/c1-17(2)32-24-22(16-26-32)28-23(29-24)18-4-8-20(9-5-18)30-12-14-31(15-13-30)25(33)27-19-6-10-21(34-3)11-7-19/h4-11,16-17H,12-15H2,1-3H3,(H,27,33)(H,28,29)
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n/an/a 3.31E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176372
PNG
(US9688696, 88)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C28H29N7O/c1-19(2)35-27-25(18-29-35)31-26(32-27)21-8-11-24(12-9-21)33-13-15-34(16-14-33)28(36)30-23-10-7-20-5-3-4-6-22(20)17-23/h3-12,17-19H,13-16H2,1-2H3,(H,30,36)(H,31,32)
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n/an/a 3.31E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176371
PNG
(US9688696, 87)
Show SMILES Cc1nc(no1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C20H19ClFN5O2/c1-13-23-19(25-29-13)14-5-7-15(8-6-14)26-9-11-27(12-10-26)20(28)24-18-16(21)3-2-4-17(18)22/h2-8H,9-12H2,1H3,(H,24,28)
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n/an/a 3.31E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176375
PNG
(US9688696, 91)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H34N8O2/c1-20(2)36-27-25(19-29-36)31-26(32-27)21-6-8-23(9-7-21)33-10-12-35(13-11-33)28(37)30-22-4-3-5-24(18-22)34-14-16-38-17-15-34/h3-9,18-20H,10-17H2,1-2H3,(H,30,37)(H,31,32)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176374
PNG
(US9688696, 90)
Show SMILES COc1cccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2nc3cnn(C(C)C)c3[nH]2)c1
Show InChI InChI=1S/C25H29N7O2/c1-17(2)32-24-22(16-26-32)28-23(29-24)18-7-9-20(10-8-18)30-11-13-31(14-12-30)25(33)27-19-5-4-6-21(15-19)34-3/h4-10,15-17H,11-14H2,1-3H3,(H,27,33)(H,28,29)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176376
PNG
(US9688696, 92)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc2OCOc2c1
Show InChI InChI=1S/C25H27N7O3/c1-16(2)32-24-20(14-26-32)28-23(29-24)17-3-6-19(7-4-17)30-9-11-31(12-10-30)25(33)27-18-5-8-21-22(13-18)35-15-34-21/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,27,33)(H,28,29)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176373
PNG
(US9688696, 101)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H27N7O/c1-17(2)31-23-21(16-25-31)27-22(28-23)18-8-10-20(11-9-18)29-12-14-30(15-13-29)24(32)26-19-6-4-3-5-7-19/h3-11,16-17H,12-15H2,1-2H3,(H,26,32)(H,27,28)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176298
PNG
(US9688696, 13)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccnn1CCc1ccccc1
Show InChI InChI=1S/C28H27Cl2N5O/c29-24-7-4-8-25(30)27(24)32-28(36)34-19-17-33(18-20-34)23-11-9-22(10-12-23)26-13-15-31-35(26)16-14-21-5-2-1-3-6-21/h1-13,15H,14,16-20H2,(H,32,36)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176299
PNG
(US9688696, 14)
Show SMILES Clc1cccc(Cl)c1CC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccnc(n1)-c1ccccc1
Show InChI InChI=1S/C28H24Cl2N4O/c29-24-7-4-8-25(30)23(24)19-27(35)34-17-15-33(16-18-34)22-11-9-20(10-12-22)26-13-14-31-28(32-26)21-5-2-1-3-6-21/h1-14H,15-19H2
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n/an/a 3.47E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176377
PNG
(US9688696, 93)
Show SMILES CCc1nc(no1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C21H21ClFN5O2/c1-2-18-24-20(26-30-18)14-6-8-15(9-7-14)27-10-12-28(13-11-27)21(29)25-19-16(22)4-3-5-17(19)23/h3-9H,2,10-13H2,1H3,(H,25,29)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176378
PNG
(US9688696, 94)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2nc3cnn(Cc4ccc(C)cc4)c3[nH]2)cc1
Show InChI InChI=1S/C30H31N7O2/c1-21-3-5-22(6-4-21)20-37-29-27(19-31-37)33-28(34-29)23-7-11-25(12-8-23)35-15-17-36(18-16-35)30(38)32-24-9-13-26(39-2)14-10-24/h3-14,19H,15-18,20H2,1-2H3,(H,32,38)(H,33,34)
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n/an/a 3.55E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176380
PNG
(US9688696, 96)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)NC2CC2)cc1
Show InChI InChI=1S/C26H29N7O/c1-18-2-4-19(5-3-18)17-33-25-23(16-27-33)29-24(30-25)20-6-10-22(11-7-20)31-12-14-32(15-13-31)26(34)28-21-8-9-21/h2-7,10-11,16,21H,8-9,12-15,17H2,1H3,(H,28,34)(H,29,30)
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n/an/a 3.55E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176379
PNG
(US9688696, 95)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C29H29N7O/c1-21-7-9-22(10-8-21)20-36-28-26(19-30-36)32-27(33-28)23-11-13-25(14-12-23)34-15-17-35(18-16-34)29(37)31-24-5-3-2-4-6-24/h2-14,19H,15-18,20H2,1H3,(H,31,37)(H,32,33)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176381
PNG
(US9688696, 97)
Show SMILES CC(=O)Nc1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2nc3cnn(Cc4ccc(C)cc4)c3[nH]2)cc1
Show InChI InChI=1S/C31H32N8O2/c1-21-3-5-23(6-4-21)20-39-30-28(19-32-39)35-29(36-30)24-7-13-27(14-8-24)37-15-17-38(18-16-37)31(41)34-26-11-9-25(10-12-26)33-22(2)40/h3-14,19H,15-18,20H2,1-2H3,(H,33,40)(H,34,41)(H,35,36)
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n/an/a 3.63E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176382
PNG
(US9688696, 98)
Show SMILES Cc1nc(no1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccccc1Br
Show InChI InChI=1S/C20H20BrN5O2/c1-14-22-19(24-28-14)15-6-8-16(9-7-15)25-10-12-26(13-11-25)20(27)23-18-5-3-2-4-17(18)21/h2-9H,10-13H2,1H3,(H,23,27)
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n/an/a 3.72E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176383
PNG
(US9688696, 99)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C30H29N7O3/c1-20-2-4-21(5-3-20)18-37-29-25(17-31-37)33-28(34-29)22-6-9-24(10-7-22)35-12-14-36(15-13-35)30(38)32-23-8-11-26-27(16-23)40-19-39-26/h2-11,16-17H,12-15,18-19H2,1H3,(H,32,38)(H,33,34)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176384
PNG
(US9688696, 100)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C24H26FN7O/c1-16(2)32-23-21(15-26-32)28-22(29-23)17-6-8-20(9-7-17)30-10-12-31(13-11-30)24(33)27-19-5-3-4-18(25)14-19/h3-9,14-16H,10-13H2,1-2H3,(H,27,33)(H,28,29)
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n/an/a 3.98E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM182966
PNG
(US9688696, 89)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H29N7O/c1-18(2)32-24-22(17-27-32)28-23(29-24)20-8-10-21(11-9-20)30-12-14-31(15-13-30)25(33)26-16-19-6-4-3-5-7-19/h3-11,17-18H,12-16H2,1-2H3,(H,26,33)(H,28,29)
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n/an/a 4.07E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176386
PNG
(US9688696, 102)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C30H31N7O/c1-22-7-9-24(10-8-22)21-37-29-27(20-32-37)33-28(34-29)25-11-13-26(14-12-25)35-15-17-36(18-16-35)30(38)31-19-23-5-3-2-4-6-23/h2-14,20H,15-19,21H2,1H3,(H,31,38)(H,33,34)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176387
PNG
(US9688696, 103)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2cccc(c2)N2CCOCC2)cc1
Show InChI InChI=1S/C33H36N8O2/c1-24-5-7-25(8-6-24)23-41-32-30(22-34-41)36-31(37-32)26-9-11-28(12-10-26)38-13-15-40(16-14-38)33(42)35-27-3-2-4-29(21-27)39-17-19-43-20-18-39/h2-12,21-22H,13-20,23H2,1H3,(H,35,42)(H,36,37)
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n/an/a 4.17E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176388
PNG
(US9688696, 104)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C25H28N6O/c1-18(2)31-25-22(17-26-31)27-24(28-25)20-8-10-21(11-9-20)29-12-14-30(15-13-29)23(32)16-19-6-4-3-5-7-19/h3-11,17-18H,12-16H2,1-2H3,(H,27,28)
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n/an/a 4.27E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176389
PNG
(US9688696, 105)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccc(C)cc2)cc1
Show InChI InChI=1S/C30H31N7O/c1-21-3-7-23(8-4-21)20-37-29-27(19-31-37)33-28(34-29)24-9-13-26(14-10-24)35-15-17-36(18-16-35)30(38)32-25-11-5-22(2)6-12-25/h3-14,19H,15-18,20H2,1-2H3,(H,32,38)(H,33,34)
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n/an/a 4.37E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176390
PNG
(US9688696, 106)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1cccc(c1)N(C)C
Show InChI InChI=1S/C26H32N8O/c1-18(2)34-25-23(17-27-34)29-24(30-25)19-8-10-21(11-9-19)32-12-14-33(15-13-32)26(35)28-20-6-5-7-22(16-20)31(3)4/h5-11,16-18H,12-15H2,1-4H3,(H,28,35)(H,29,30)
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n/an/a 4.68E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176391
PNG
(US9688696, 107)
Show SMILES Fc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CC1
Show InChI InChI=1S/C22H21ClFN5O2/c23-17-2-1-3-18(24)19(17)25-22(30)29-12-10-28(11-13-29)16-8-6-14(7-9-16)20-26-21(31-27-20)15-4-5-15/h1-3,6-9,15H,4-5,10-13H2,(H,25,30)
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n/an/a 4.79E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176300
PNG
(US9688696, 15)
Show SMILES CCCCn1nccc1-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H27Cl2N5O/c1-2-3-13-31-22(11-12-27-31)18-7-9-19(10-8-18)29-14-16-30(17-15-29)24(32)28-23-20(25)5-4-6-21(23)26/h4-12H,2-3,13-17H2,1H3,(H,28,32)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176392
PNG
(US9688696, 108)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C30H30N6O/c1-22-7-9-24(10-8-22)21-36-30-27(20-31-36)32-29(33-30)25-11-13-26(14-12-25)34-15-17-35(18-16-34)28(37)19-23-5-3-2-4-6-23/h2-14,20H,15-19,21H2,1H3,(H,32,33)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176393
PNG
(US9688696, 109)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2ccc(cc2)-c2noc(n2)C2CCCCC2)c(OC)c1
Show InChI InChI=1S/C27H33N5O4/c1-34-22-12-13-23(24(18-22)35-2)28-27(33)32-16-14-31(15-17-32)21-10-8-19(9-11-21)25-29-26(36-30-25)20-6-4-3-5-7-20/h8-13,18,20H,3-7,14-17H2,1-2H3,(H,28,33)
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n/an/a 5.37E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176306
PNG
(US9688696, 21)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1ccnc(n1)N1CCCCC1
Show InChI InChI=1S/C26H28Cl2N6O/c27-21-5-4-6-22(28)24(21)31-26(35)34-17-15-32(16-18-34)20-9-7-19(8-10-20)23-11-12-29-25(30-23)33-13-2-1-3-14-33/h4-12H,1-3,13-18H2,(H,31,35)
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n/an/a 5.75E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176301
PNG
(US9688696, 16)
Show SMILES CC(C)(C)c1nccc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H27Cl2N5O/c1-25(2,3)23-28-12-11-21(29-23)17-7-9-18(10-8-17)31-13-15-32(16-14-31)24(33)30-22-19(26)5-4-6-20(22)27/h4-12H,13-16H2,1-3H3,(H,30,33)
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n/an/a 6.46E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


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More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176302
PNG
(US9688696, 17)
Show SMILES CCOC(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C29H33Cl2N7O3/c1-2-41-29(40)38-14-11-21(12-15-38)33-27-32-13-10-25(34-27)20-6-8-22(9-7-20)36-16-18-37(19-17-36)28(39)35-26-23(30)4-3-5-24(26)31/h3-10,13,21H,2,11-12,14-19H2,1H3,(H,35,39)(H,32,33,34)
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n/an/a 6.76E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176394
PNG
(US9688696, 110)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)CCc2ccccc2)cc1
Show InChI InChI=1S/C31H32N6O/c1-23-7-9-25(10-8-23)22-37-31-28(21-32-37)33-30(34-31)26-12-14-27(15-13-26)35-17-19-36(20-18-35)29(38)16-11-24-5-3-2-4-6-24/h2-10,12-15,21H,11,16-20,22H2,1H3,(H,33,34)
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n/an/a 7.24E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176395
PNG
(US9688696, 111)
Show SMILES Cc1nc(no1)-c1ccc(cc1)N1CCN(CC1)C(=O)Cc1ccccc1Br
Show InChI InChI=1S/C21H21BrN4O2/c1-15-23-21(24-28-15)16-6-8-18(9-7-16)25-10-12-26(13-11-25)20(27)14-17-4-2-3-5-19(17)22/h2-9H,10-14H2,1H3
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n/an/a 7.59E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176396
PNG
(US9688696, 112)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN7O/c1-16(2)32-23-21(15-26-32)28-22(29-23)17-3-9-20(10-4-17)30-11-13-31(14-12-30)24(33)27-19-7-5-18(25)6-8-19/h3-10,15-16H,11-14H2,1-2H3,(H,27,33)(H,28,29)
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n/an/a 7.94E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176397
PNG
(US9688696, 113)
Show SMILES Brc1ccccc1CC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CCC1
Show InChI InChI=1S/C24H25BrN4O2/c25-21-7-2-1-4-19(21)16-22(30)29-14-12-28(13-15-29)20-10-8-17(9-11-20)23-26-24(31-27-23)18-5-3-6-18/h1-2,4,7-11,18H,3,5-6,12-16H2
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n/an/a 8.13E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176398
PNG
(US9688696, 114)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C23H26N8O/c1-16(2)31-22-20(15-25-31)27-21(28-22)17-3-5-19(6-4-17)29-11-13-30(14-12-29)23(32)26-18-7-9-24-10-8-18/h3-10,15-16H,11-14H2,1-2H3,(H,27,28)(H,24,26,32)
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n/an/a 8.51E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176303
PNG
(US9688696, 18)
Show SMILES COc1ccc(cc1)-n1nccc1-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C27H25Cl2N5O2/c1-36-22-11-9-21(10-12-22)34-25(13-14-30-34)19-5-7-20(8-6-19)32-15-17-33(18-16-32)27(35)31-26-23(28)3-2-4-24(26)29/h2-14H,15-18H2,1H3,(H,31,35)
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n/an/a 8.91E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176399
PNG
(US9688696, 115)
Show SMILES CC(C)n1ncc2nc([nH]c12)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H27N7O3/c1-16(2)32-23-21(15-26-32)28-22(29-23)17-5-9-20(10-6-17)30-11-13-31(14-12-30)25(35)27-19-7-3-18(4-8-19)24(33)34/h3-10,15-16H,11-14H2,1-2H3,(H,27,35)(H,28,29)(H,33,34)
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n/an/a 8.91E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176400
PNG
(US9688696, 116)
Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C29H28ClN7O/c1-20-2-4-21(5-3-20)19-37-28-26(18-31-37)33-27(34-28)22-6-12-25(13-7-22)35-14-16-36(17-15-35)29(38)32-24-10-8-23(30)9-11-24/h2-13,18H,14-17,19H2,1H3,(H,32,38)(H,33,34)
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n/an/a 9.12E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176401
PNG
(US9688696, 117)
Show SMILES Brc1ccccc1CC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CC1
Show InChI InChI=1S/C23H23BrN4O2/c24-20-4-2-1-3-18(20)15-21(29)28-13-11-27(12-14-28)19-9-7-16(8-10-19)22-25-23(30-26-22)17-5-6-17/h1-4,7-10,17H,5-6,11-15H2
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n/an/a 9.12E+3n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%