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Patent code US9688710

Compile Data Set for Download or QSAR

Found 328 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176404
PNG
(US9688710, 3 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(N)=O)cc2)c1
Show InChI InChI=1S/C23H28ClNO6S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H2,25,26)/t19-,20-,21+,22+,23-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176410
PNG
(US9688710, 9 N-(1-amino-2-methyl-1-oxopropan-2-yl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C28H38N2O6S/c1-16-8-13-19(25-23(33)22(32)24(34)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(31)30-28(2,3)27(29)35/h8-13,15,22-26,32-34H,5-7,14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176424
PNG
(US9688710, 23 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C29H41NO8S/c1-18-7-12-21(27-25(36)24(35)26(37)28(38-27)39-2)14-22(18)13-20-10-8-19(9-11-20)5-3-4-6-23(34)30-29(15-31,16-32)17-33/h7-12,14,24-28,31-33,35-37H,3-6,13,15-17H2,1-2H3,(H,30,34)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176426
PNG
(US9688710, 25 5-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C30H42N2O5S/c1-20-8-13-23(29-27(35)26(34)28(36)30(37-29)38-3)19-24(20)18-22-11-9-21(10-12-22)6-4-5-7-25(33)32-16-14-31(2)15-17-32/h8-13,19,26-30,34-36H,4-7,14-18H2,1-3H3/t26-,27-,28+,29+,30-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176432
PNG
(US9688710, 31 (S)-2-amino-6-(5-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1
Show InChI InChI=1S/C31H44N2O7S/c1-19-10-15-22(29-27(36)26(35)28(37)31(40-29)41-2)18-23(19)17-21-13-11-20(12-14-21)7-3-4-9-25(34)33-16-6-5-8-24(32)30(38)39/h10-15,18,24,26-29,31,35-37H,3-9,16-17,32H2,1-2H3,(H,33,34)(H,38,39)/t24-,26+,27+,28-,29-,31+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176439
PNG
(US9688710, 38 2,2-dimethyl-3-(2-(4-(2-methyl-5-((2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(=O)NCC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C27H36N2O7S/c1-15-5-8-17(24-22(32)21(31)23(33)25(36-24)37-4)12-18(15)11-16-6-9-19(10-7-16)35-13-20(30)29-14-27(2,3)26(28)34/h5-10,12,21-25,31-33H,11,13-14H2,1-4H3,(H2,28,34)(H,29,30)/t21-,22-,23+,24+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176441
PNG
(US9688710, 40 N-(1-hydroxy-2-methylpropan-2-yl)-4-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)CO)cc2)c1
Show InChI InChI=1S/C27H37NO7S/c1-16-6-9-19(26-24(32)23(31)25(33)27(35-26)36-3)14-20(16)13-18-7-10-21(11-8-18)34-12-4-5-22(30)28-17(2)15-29/h6-11,14,17,23-27,29,31-33H,4-5,12-13,15H2,1-3H3,(H,28,30)/t17?,23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176457
PNG
(US9688710, 56 N-((R)-1-amino-1-oxopropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@H](C)C(N)=O)cc2)c1
Show InChI InChI=1S/C27H36N2O7S/c1-15-6-9-18(25-23(32)22(31)24(33)27(36-25)37-3)14-19(15)13-17-7-10-20(11-8-17)35-12-4-5-21(30)29-16(2)26(28)34/h6-11,14,16,22-25,27,31-33H,4-5,12-13H2,1-3H3,(H2,28,34)(H,29,30)/t16-,22-,23-,24+,25+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176491
PNG
(US9688710, 72 (2S,3R,4R,5S,6R)-2-(3-(4-(2-aminoeth...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCN)cc2)c1
Show InChI InChI=1S/C21H26ClNO5S/c1-29-21-19(26)17(24)18(25)20(28-21)13-4-7-16(22)14(11-13)10-12-2-5-15(6-3-12)27-9-8-23/h2-7,11,17-21,24-26H,8-10,23H2,1H3/t17-,18-,19+,20+,21-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176521
PNG
(US9688710, 86 N-ethyl-4-(4-(2-methyl-5-((2S,3R,4R,...)
Show SMILES CCNC(=O)CCCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C26H35NO6S/c1-4-27-21(28)6-5-13-32-20-11-8-17(9-12-20)14-19-15-18(10-7-16(19)2)25-23(30)22(29)24(31)26(33-25)34-3/h7-12,15,22-26,29-31H,4-6,13-14H2,1-3H3,(H,27,28)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176523
PNG
(US9688710, 148 4-methyl-N-(2-(4-(2-methyl-5-((3R,4...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNC(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C28H39N3O6S/c1-18-4-7-20(26-24(33)23(32)25(34)27(37-26)38-3)17-21(18)16-19-5-8-22(9-6-19)36-15-10-29-28(35)31-13-11-30(2)12-14-31/h4-9,17,23-27,32-34H,10-16H2,1-3H3,(H,29,35)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176532
PNG
(US9688710, 95 1-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C26H35ClN2O7S/c1-26(2,14-30)29-25(34)28-10-11-35-18-7-4-15(5-8-18)12-17-13-16(6-9-19(17)27)23-21(32)20(31)22(33)24(36-23)37-3/h4-9,13,20-24,30-33H,10-12,14H2,1-3H3,(H2,28,29,34)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176414
PNG
(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-5)20-25(21)19-23-12-10-22(11-13-23)7-6-8-26(37)34-33(2,3)32(41)36-17-15-35(4)16-18-36/h9-14,20,27-31,38-40H,6-8,15-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176693
PNG
(US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC3(CC3)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C33H45N3O6S/c1-21-7-12-24(30-28(39)27(38)29(40)31(42-30)43-3)20-25(21)19-23-10-8-22(9-11-23)5-4-6-26(37)34-33(13-14-33)32(41)36-17-15-35(2)16-18-36/h7-12,20,27-31,38-40H,4-6,13-19H2,1-3H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176697
PNG
(US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCC(C)CC3)cc2)c1
Show InChI InChI=1S/C34H48N2O6S/c1-21-15-17-36(18-16-21)33(41)34(3,4)35-27(37)8-6-7-23-10-12-24(13-11-23)19-26-20-25(14-9-22(26)2)31-29(39)28(38)30(40)32(42-31)43-5/h9-14,20-21,28-32,38-40H,6-8,15-19H2,1-5H3,(H,35,37)/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176709
PNG
(US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N(C)CCN(C)C)cc2)c1
Show InChI InChI=1S/C33H49N3O6S/c1-21-11-16-24(30-28(39)27(38)29(40)31(42-30)43-7)20-25(21)19-23-14-12-22(13-15-23)9-8-10-26(37)34-33(2,3)32(41)36(6)18-17-35(4)5/h11-16,20,27-31,38-40H,8-10,17-19H2,1-7H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176719
PNG
(US9688710, 141 N-(2,2-dimethyl-3-(4-methylpiperazi...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NCC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C34H49N3O7S/c1-22-8-11-24(31-29(40)28(39)30(41)32(44-31)45-5)20-25(22)19-23-9-12-26(13-10-23)43-18-6-7-27(38)35-21-34(2,3)33(42)37-16-14-36(4)15-17-37/h8-13,20,28-32,39-41H,6-7,14-19,21H2,1-5H3,(H,35,38)/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176723
PNG
(US9688710, 145 (3R,4R,5S,6R)-2-(3-(4-(3-((3-hydrox...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNCC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C28H41NO6S/c1-18-6-9-20(26-24(32)23(31)25(33)27(35-26)36-4)15-21(18)14-19-7-10-22(11-8-19)34-13-5-12-29-16-28(2,3)17-30/h6-11,15,23-27,29-33H,5,12-14,16-17H2,1-4H3/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


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More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176405
PNG
(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(O)CO)cc2)c1
Show InChI InChI=1S/C23H30O7S/c1-13-3-6-15(22-20(27)19(26)21(28)23(30-22)31-2)10-16(13)9-14-4-7-18(8-5-14)29-12-17(25)11-24/h3-8,10,17,19-28H,9,11-12H2,1-2H3/t17?,19-,20-,21+,22+,23-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176408
PNG
(US9688710, 7 (S,E)-2-amino-5-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CC(N)C(O)=O)cc2)c1
Show InChI InChI=1S/C25H31NO6S/c1-14-6-11-17(23-21(28)20(27)22(29)25(32-23)33-2)13-18(14)12-16-9-7-15(8-10-16)4-3-5-19(26)24(30)31/h3-4,6-11,13,19-23,25,27-29H,5,12,26H2,1-2H3,(H,30,31)/b4-3+/t19?,20-,21-,22+,23+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176410
PNG
(US9688710, 9 N-(1-amino-2-methyl-1-oxopropan-2-yl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C28H38N2O6S/c1-16-8-13-19(25-23(33)22(32)24(34)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(31)30-28(2,3)27(29)35/h8-13,15,22-26,32-34H,5-7,14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176416
PNG
(US9688710, 15 2-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C30H40ClN3O7S/c1-30(2,29(39)34-13-11-33(3)12-14-34)32-23(35)17-40-21-8-5-18(6-9-21)15-20-16-19(7-10-22(20)31)27-25(37)24(36)26(38)28(41-27)42-4/h5-10,16,24-28,36-38H,11-15,17H2,1-4H3,(H,32,35)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176417
PNG
(US9688710, 16 (S)-2-amino-6-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1
Show InChI InChI=1S/C30H42N2O7S/c1-18-9-14-21(28-26(35)25(34)27(36)30(39-28)40-2)17-22(18)16-20-12-10-19(11-13-20)6-5-8-24(33)32-15-4-3-7-23(31)29(37)38/h9-14,17,23,25-28,30,34-36H,3-8,15-16,31H2,1-2H3,(H,32,33)(H,37,38)/t23-,25+,26+,27-,28-,30+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176427
PNG
(US9688710, 26 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-4)20-25(21)19-23-12-10-22(11-13-23)7-5-6-8-26(37)35-33(2,3)32(41)36-17-15-34-16-18-36/h9-14,20,27-31,34,38-40H,5-8,15-19H2,1-4H3,(H,35,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176434
PNG
(US9688710, 33 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C28H38N2O7S/c1-16-7-10-18(25-23(33)22(32)24(34)26(37-25)38-4)15-19(16)14-17-8-11-20(12-9-17)36-13-5-6-21(31)30-28(2,3)27(29)35/h7-12,15,22-26,32-34H,5-6,13-14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176443
PNG
(US9688710, 42 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C26H35NO9S/c1-15-3-6-17(24-22(33)21(32)23(34)25(36-24)37-2)10-18(15)9-16-4-7-19(8-5-16)35-11-20(31)27-26(12-28,13-29)14-30/h3-8,10,21-25,28-30,32-34H,9,11-14H2,1-2H3,(H,27,31)/t21-,22-,23+,24+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176444
PNG
(US9688710, 43 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C28H39NO9S/c1-17-5-8-19(26-24(35)23(34)25(36)27(38-26)39-2)13-20(17)12-18-6-9-21(10-7-18)37-11-3-4-22(33)29-28(14-30,15-31)16-32/h5-10,13,23-27,30-32,34-36H,3-4,11-12,14-16H2,1-2H3,(H,29,33)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176449
PNG
(US9688710, 48 N-((S)-1-amino-3-hydroxy-1-oxopropan...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@@](C)(CO)C(N)=O)cc2)c1
Show InChI InChI=1S/C28H38N2O8S/c1-16-6-9-18(25-23(34)22(33)24(35)26(38-25)39-3)14-19(16)13-17-7-10-20(11-8-17)37-12-4-5-21(32)30-28(2,15-31)27(29)36/h6-11,14,22-26,31,33-35H,4-5,12-13,15H2,1-3H3,(H2,29,36)(H,30,32)/t22-,23-,24+,25+,26-,28+/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176451
PNG
(US9688710, 50 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C30H43NO8S/c1-19-8-13-22(28-26(37)25(36)27(38)29(39-28)40-2)15-23(19)14-21-11-9-20(10-12-21)6-4-3-5-7-24(35)31-30(16-32,17-33)18-34/h8-13,15,25-29,32-34,36-38H,3-7,14,16-18H2,1-2H3,(H,31,35)/t25-,26-,27+,28+,29-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176452
PNG
(US9688710, 51 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C30H42N2O6S/c1-18-10-15-21(27-25(35)24(34)26(36)28(38-27)39-4)17-22(18)16-20-13-11-19(12-14-20)8-6-5-7-9-23(33)32-30(2,3)29(31)37/h10-15,17,24-28,34-36H,5-9,16H2,1-4H3,(H2,31,37)(H,32,33)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176456
PNG
(US9688710, 55 N-(1,3-dihydroxypropan-2-yl)-4-(4-(2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(CO)CO)cc2)c1
Show InChI InChI=1S/C27H37NO8S/c1-16-5-8-18(26-24(33)23(32)25(34)27(36-26)37-2)13-19(16)12-17-6-9-21(10-7-17)35-11-3-4-22(31)28-20(14-29)15-30/h5-10,13,20,23-27,29-30,32-34H,3-4,11-12,14-15H2,1-2H3,(H,28,31)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


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More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176461
PNG
(US9688710, 60 N-(1-hydroxy-2-methylpropan-2-yl)-7-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C31H45NO6S/c1-20-11-16-23(29-27(36)26(35)28(37)30(38-29)39-4)18-24(20)17-22-14-12-21(13-15-22)9-7-5-6-8-10-25(34)32-31(2,3)19-33/h11-16,18,26-30,33,35-37H,5-10,17,19H2,1-4H3,(H,32,34)/t26-,27-,28+,29+,30-/m1/s1
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Lexicon Pharmaceuticals, Inc.

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Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


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More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176484
PNG
(US9688710, 65 N-(3-amino-2,2-dimethyl-3-oxopropyl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(=O)NCC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C28H37ClN2O7S/c1-28(2,27(30)36)15-31-21(32)5-4-12-37-19-9-6-16(7-10-19)13-18-14-17(8-11-20(18)29)25-23(34)22(33)24(35)26(38-25)39-3/h6-11,14,22-26,33-35H,4-5,12-13,15H2,1-3H3,(H2,30,36)(H,31,32)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

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Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


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More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176519
PNG
(US9688710, 85 N-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNC(=O)C(C)(C)CO)cc2)c1
Show InChI InChI=1S/C27H37NO7S/c1-16-5-8-18(24-22(31)21(30)23(32)25(35-24)36-4)14-19(16)13-17-6-9-20(10-7-17)34-12-11-28-26(33)27(2,3)15-29/h5-10,14,21-25,29-32H,11-13,15H2,1-4H3,(H,28,33)/t21-,22-,23+,24+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

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Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


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More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176530
PNG
(US9688710, 93 (2S,3R,4R,5S,6R)-2-(3-(4-(4-(bis(2,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCN(CC(O)CO)CC(O)CO)cc2)c1
Show InChI InChI=1S/C30H45NO8S/c1-19-6-11-22(29-27(37)26(36)28(38)30(39-29)40-2)14-23(19)13-21-9-7-20(8-10-21)5-3-4-12-31(15-24(34)17-32)16-25(35)18-33/h6-11,14,24-30,32-38H,3-5,12-13,15-18H2,1-2H3/t24?,25?,26-,27-,28+,29+,30-/m1/s1
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Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


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More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176621
PNG
(US9688710, 106 N-(4-(4-(2-methyl-5-((2S,3R,4R,5S,6...)
Show SMILES CCC(=O)NCCCCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C27H37NO5S/c1-4-22(29)28-14-6-5-7-18-9-11-19(12-10-18)15-21-16-20(13-8-17(21)2)26-24(31)23(30)25(32)27(33-26)34-3/h8-13,16,23-27,30-32H,4-7,14-15H2,1-3H3,(H,28,29)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176685
PNG
(US9688710, 110 1-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(N)=N)cc2)c1
Show InChI InChI=1S/C22H28ClN3O5S/c1-32-21-19(29)17(27)18(28)20(31-21)13-4-7-16(23)14(11-13)10-12-2-5-15(6-3-12)30-9-8-26-22(24)25/h2-7,11,17-21,27-29H,8-10H2,1H3,(H4,24,25,26)/t17-,18-,19+,20+,21-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176685
PNG
(US9688710, 110 1-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(N)=N)cc2)c1
Show InChI InChI=1S/C22H28ClN3O5S/c1-32-21-19(29)17(27)18(28)20(31-21)13-4-7-16(23)14(11-13)10-12-2-5-15(6-3-12)30-9-8-26-22(24)25/h2-7,11,17-21,27-29H,8-10H2,1H3,(H4,24,25,26)/t17-,18-,19+,20+,21-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176692
PNG
(US9688710, 115 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC3(CCOCC3)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C35H49N3O7S/c1-23-7-12-26(32-30(41)29(40)31(42)33(45-32)46-3)22-27(23)21-25-10-8-24(9-11-25)5-4-6-28(39)36-35(13-19-44-20-14-35)34(43)38-17-15-37(2)16-18-38/h7-12,22,29-33,40-42H,4-6,13-21H2,1-3H3,(H,36,39)/t29-,30-,31+,32+,33-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176705
PNG
(US9688710, 128 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNCC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C34H51N3O5S/c1-23-9-14-26(31-29(39)28(38)30(40)32(42-31)43-5)21-27(23)20-25-12-10-24(11-13-25)8-6-7-15-35-22-34(2,3)33(41)37-18-16-36(4)17-19-37/h9-14,21,28-32,35,38-40H,6-8,15-20,22H2,1-5H3/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176710
PNG
(US9688710, 133 N-(2-methyl-1-(methylamino)-1-oxopr...)
Show SMILES CNC(=O)C(C)(C)NC(=O)CCCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C29H40N2O6S/c1-17-9-14-20(26-24(34)23(33)25(35)27(37-26)38-5)16-21(17)15-19-12-10-18(11-13-19)7-6-8-22(32)31-29(2,3)28(36)30-4/h9-14,16,23-27,33-35H,6-8,15H2,1-5H3,(H,30,36)(H,31,32)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176722
PNG
(US9688710, 144 1-((3-(4-(2-methyl-5-((3R,4R,5S,6R)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNC(=O)C3CCCC3)cc2)c1
Show InChI InChI=1S/C29H39NO6S/c1-18-8-11-21(27-25(32)24(31)26(33)29(36-27)37-2)17-22(18)16-19-9-12-23(13-10-19)35-15-5-14-30-28(34)20-6-3-4-7-20/h8-13,17,20,24-27,29,31-33H,3-7,14-16H2,1-2H3,(H,30,34)/t24-,25-,26+,27+,29-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176733
PNG
(US9688710, 154 N-(2-amino-2-methylpropyl)-4-(4-(2-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)CN)cc2)c1
Show InChI InChI=1S/C28H40N2O5S/c1-17(15-29)16-30-23(31)6-4-5-19-8-10-20(11-9-19)13-22-14-21(12-7-18(22)2)27-25(33)24(32)26(34)28(35-27)36-3/h7-12,14,17,24-28,32-34H,4-6,13,15-16,29H2,1-3H3,(H,30,31)/t17?,24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176735
PNG
(US9688710, 156 N-(2-methyl-1-oxo-1-(piperidin-4-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(=O)NC3CCNCC3)cc2)c1
Show InChI InChI=1S/C33H47N3O7S/c1-20-7-10-22(30-28(39)27(38)29(40)31(43-30)44-4)19-23(20)18-21-8-11-25(12-9-21)42-17-5-6-26(37)36-33(2,3)32(41)35-24-13-15-34-16-14-24/h7-12,19,24,27-31,34,38-40H,5-6,13-18H2,1-4H3,(H,35,41)(H,36,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176406
PNG
(US9688710, 5 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-...)
Show SMILES COCCOCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H31ClO7S/c1-29-9-10-30-11-12-31-18-6-3-15(4-7-18)13-17-14-16(5-8-19(17)25)23-21(27)20(26)22(28)24(32-23)33-2/h3-8,14,20-24,26-28H,9-13H2,1-2H3/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176411
PNG
(US9688710, 10 (2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzy...)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5S/c1-4-26-17-9-6-14(7-10-17)11-16-12-15(8-5-13(16)2)21-19(24)18(23)20(25)22(27-21)28-3/h5-10,12,18-25H,4,11H2,1-3H3/t18-,19-,20+,21+,22-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176414
PNG
(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-5)20-25(21)19-23-12-10-22(11-13-23)7-6-8-26(37)34-33(2,3)32(41)36-17-15-35(4)16-18-36/h9-14,20,27-31,38-40H,6-8,15-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176419
PNG
(US9688710, 18 (S)-2-amino-6-(4-(2-chloro-5-((2S,3R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC[C@H](N)C(O)=O)cc2)c1
Show InChI InChI=1S/C25H32ClNO7S/c1-35-25-22(30)20(28)21(29)23(34-25)15-7-10-18(26)16(13-15)12-14-5-8-17(9-6-14)33-11-3-2-4-19(27)24(31)32/h5-10,13,19-23,25,28-30H,2-4,11-12,27H2,1H3,(H,31,32)/t19-,20+,21+,22-,23-,25+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176420
PNG
(US9688710, 19 (E)-N-(1,3-dihydroxy-2-(hydroxymethy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C29H39NO8S/c1-18-7-12-21(27-25(36)24(35)26(37)28(38-27)39-2)14-22(18)13-20-10-8-19(9-11-20)5-3-4-6-23(34)30-29(15-31,16-32)17-33/h3,5,7-12,14,24-28,31-33,35-37H,4,6,13,15-17H2,1-2H3,(H,30,34)/b5-3+/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%