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Patent code US9688710

Compile Data Set for Download or QSAR

Found 328 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176456
PNG
(US9688710, 55 N-(1,3-dihydroxypropan-2-yl)-4-(4-(2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(CO)CO)cc2)c1
Show InChI InChI=1S/C27H37NO8S/c1-16-5-8-18(26-24(33)23(32)25(34)27(36-26)37-2)13-19(16)12-17-6-9-21(10-7-17)35-11-3-4-22(31)28-20(14-29)15-30/h5-10,13,20,23-27,29-30,32-34H,3-4,11-12,14-15H2,1-2H3,(H,28,31)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176456
PNG
(US9688710, 55 N-(1,3-dihydroxypropan-2-yl)-4-(4-(2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(CO)CO)cc2)c1
Show InChI InChI=1S/C27H37NO8S/c1-16-5-8-18(26-24(33)23(32)25(34)27(36-26)37-2)13-19(16)12-17-6-9-21(10-7-17)35-11-3-4-22(31)28-20(14-29)15-30/h5-10,13,20,23-27,29-30,32-34H,3-4,11-12,14-15H2,1-2H3,(H,28,31)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176461
PNG
(US9688710, 60 N-(1-hydroxy-2-methylpropan-2-yl)-7-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C31H45NO6S/c1-20-11-16-23(29-27(36)26(35)28(37)30(38-29)39-4)18-24(20)17-22-14-12-21(13-15-22)9-7-5-6-8-10-25(34)32-31(2,3)19-33/h11-16,18,26-30,33,35-37H,5-10,17,19H2,1-4H3,(H,32,34)/t26-,27-,28+,29+,30-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176488
PNG
(US9688710, 69 2-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(N)=O)cc2)c1
Show InChI InChI=1S/C22H27NO6S/c1-12-3-6-14(21-19(26)18(25)20(27)22(29-21)30-2)10-15(12)9-13-4-7-16(8-5-13)28-11-17(23)24/h3-8,10,18-22,25-27H,9,11H2,1-2H3,(H2,23,24)/t18-,19-,20+,21+,22-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176513
PNG
(US9688710, 80 (2S,3R,4R,5S,6R)-2-(3-(4-(5-(benzyla...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCNCc3ccccc3)cc2)c1
Show InChI InChI=1S/C32H41NO4S/c1-22-12-17-26(31-29(35)28(34)30(36)32(37-31)38-2)20-27(22)19-24-15-13-23(14-16-24)9-7-4-8-18-33-21-25-10-5-3-6-11-25/h3,5-6,10-17,20,28-36H,4,7-9,18-19,21H2,1-2H3/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176519
PNG
(US9688710, 85 N-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNC(=O)C(C)(C)CO)cc2)c1
Show InChI InChI=1S/C27H37NO7S/c1-16-5-8-18(24-22(31)21(30)23(32)25(35-24)36-4)14-19(16)13-17-6-9-20(10-7-17)34-12-11-28-26(33)27(2,3)15-29/h5-10,14,21-25,29-32H,11-13,15H2,1-4H3,(H,28,33)/t21-,22-,23+,24+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176528
PNG
(US9688710, 91 2-methyl-2-(3-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C29H41N3O6S/c1-17-8-13-20(25-23(34)22(33)24(35)26(38-25)39-4)16-21(17)15-19-11-9-18(10-12-19)7-5-6-14-31-28(37)32-29(2,3)27(30)36/h8-13,16,22-26,33-35H,5-7,14-15H2,1-4H3,(H2,30,36)(H2,31,32,37)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176530
PNG
(US9688710, 93 (2S,3R,4R,5S,6R)-2-(3-(4-(4-(bis(2,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCN(CC(O)CO)CC(O)CO)cc2)c1
Show InChI InChI=1S/C30H45NO8S/c1-19-6-11-22(29-27(37)26(36)28(38)30(39-29)40-2)14-23(19)13-21-9-7-20(8-10-21)5-3-4-12-31(15-24(34)17-32)16-25(35)18-33/h6-11,14,24-30,32-38H,3-5,12-13,15-18H2,1-2H3/t24?,25?,26-,27-,28+,29+,30-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176532
PNG
(US9688710, 95 1-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C26H35ClN2O7S/c1-26(2,14-30)29-25(34)28-10-11-35-18-7-4-15(5-8-18)12-17-13-16(6-9-19(17)27)23-21(32)20(31)22(33)24(36-23)37-3/h4-9,13,20-24,30-33H,10-12,14H2,1-3H3,(H2,28,29,34)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176627
PNG
(US9688710, 107 2-(3-(3-(4-(2-chloro-5-((2S,3R,4R,5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCNC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C27H36ClN3O7S/c1-27(2,25(29)35)31-26(36)30-11-4-12-37-18-8-5-15(6-9-18)13-17-14-16(7-10-19(17)28)23-21(33)20(32)22(34)24(38-23)39-3/h5-10,14,20-24,32-34H,4,11-13H2,1-3H3,(H2,29,35)(H2,30,31,36)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176683
PNG
(US9688710, 109 1-(3-(4-(2-chloro-5-((2S,3R,4R,5S,6...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCNC(N)=N)cc2)c1
Show InChI InChI=1S/C23H30ClN3O5S/c1-33-22-20(30)18(28)19(29)21(32-22)14-5-8-17(24)15(12-14)11-13-3-6-16(7-4-13)31-10-2-9-27-23(25)26/h3-8,12,18-22,28-30H,2,9-11H2,1H3,(H4,25,26,27)/t18-,19-,20+,21+,22-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176703
PNG
(US9688710, 126 (S,R,S,R,R)-1,1′-(4,4′-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)N3CCN(CCCN4CCN(CC4)C(=O)CCCc4ccc(Cc5cc(ccc5C)[C@@H]5O[C@H](SC)[C@@H](O)[C@H](O)[C@H]5O)cc4)CC3)cc2)c1
Show InChI InChI=1S/C59H80N4O10S2/c1-38-12-22-44(56-52(68)50(66)54(70)58(72-56)74-3)36-46(38)34-42-18-14-40(15-19-42)8-5-10-48(64)62-30-26-60(27-31-62)24-7-25-61-28-32-63(33-29-61)49(65)11-6-9-41-16-20-43(21-17-41)35-47-37-45(23-13-39(47)2)57-53(69)51(67)55(71)59(73-57)75-4/h12-23,36-37,50-59,66-71H,5-11,24-35H2,1-4H3/t50-,51-,52-,53-,54+,55+,56+,57+,58-,59-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176706
PNG
(US9688710, 129 2-methyl-2-((4-(4-(2-methyl-5-((2S,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C33H49N3O5S/c1-22-9-14-25(30-28(38)27(37)29(39)31(41-30)42-5)21-26(22)20-24-12-10-23(11-13-24)8-6-7-15-34-33(2,3)32(40)36-18-16-35(4)17-19-36/h9-14,21,27-31,34,37-39H,6-8,15-20H2,1-5H3/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176729
PNG
(US9688710, 150 2,2-dimethyl-3-(3-(2-(4-(2-methyl-5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNC(=O)NCC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C28H39N3O7S/c1-16-5-8-18(24-22(33)21(32)23(34)25(38-24)39-4)14-19(16)13-17-6-9-20(10-7-17)37-12-11-30-27(36)31-15-28(2,3)26(29)35/h5-10,14,21-25,32-34H,11-13,15H2,1-4H3,(H2,29,35)(H2,30,31,36)/t21-,22-,23+,24+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176730
PNG
(US9688710, 151 2,2-dimethyl-3-(4-(4-(2-methyl-5-((...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)(C)C(O)=O)cc2)c1
Show InChI InChI=1S/C29H39NO7S/c1-17-8-13-20(26-24(33)23(32)25(34)27(37-26)38-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)30-16-29(2,3)28(35)36/h8-13,15,23-27,32-34H,5-7,14,16H2,1-4H3,(H,30,31)(H,35,36)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176733
PNG
(US9688710, 154 N-(2-amino-2-methylpropyl)-4-(4-(2-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)CN)cc2)c1
Show InChI InChI=1S/C28H40N2O5S/c1-17(15-29)16-30-23(31)6-4-5-19-8-10-20(11-9-19)13-22-14-21(12-7-18(22)2)27-25(33)24(32)26(34)28(35-27)36-3/h7-12,14,17,24-28,32-34H,4-6,13,15-16,29H2,1-3H3,(H,30,31)/t17?,24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176742
PNG
(US9688710, 162 2-(5-(3-(4-(2-methyl-5-((2S,3R,4R,5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCc3nnnn3CC(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C31H42N6O5S/c1-20-7-12-23(30-28(40)27(39)29(41)31(42-30)43-3)18-24(20)17-22-10-8-21(9-11-22)5-4-6-25-32-33-34-37(25)19-26(38)36-15-13-35(2)14-16-36/h7-12,18,27-31,39-41H,4-6,13-17,19H2,1-3H3/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176743
PNG
(US9688710, 163 2-(5-(3-(4-(2-methyl-5-((2S,3R,4R,5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCc3nnn(CC(=O)N4CCN(C)CC4)n3)cc2)c1
Show InChI InChI=1S/C31H42N6O5S/c1-20-7-12-23(30-28(40)27(39)29(41)31(42-30)43-3)18-24(20)17-22-10-8-21(9-11-22)5-4-6-25-32-34-37(33-25)19-26(38)36-15-13-35(2)14-16-36/h7-12,18,27-31,39-41H,4-6,13-17,19H2,1-3H3/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176402
PNG
(US9688710, 1 (E)-3-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C28H36N2O5S/c1-18-4-10-21(27-25(33)24(32)26(34)28(35-27)36-3)17-22(18)16-20-7-5-19(6-8-20)9-11-23(31)30-14-12-29(2)13-15-30/h4-11,17,24-28,32-34H,12-16H2,1-3H3/b11-9+/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176413
PNG
(US9688710, 12 2-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C25H31ClN2O7S/c1-25(2,24(27)33)28-18(29)12-34-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)26)22-20(31)19(30)21(32)23(35-22)36-3/h4-9,11,19-23,30-32H,10,12H2,1-3H3,(H2,27,33)(H,28,29)/t19-,20-,21+,22+,23-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176415
PNG
(US9688710, 14 2-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C25H32ClNO9S/c1-37-24-22(34)20(32)21(33)23(36-24)15-4-7-18(26)16(9-15)8-14-2-5-17(6-3-14)35-10-19(31)27-25(11-28,12-29)13-30/h2-7,9,20-24,28-30,32-34H,8,10-13H2,1H3,(H,27,31)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176417
PNG
(US9688710, 16 (S)-2-amino-6-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1
Show InChI InChI=1S/C30H42N2O7S/c1-18-9-14-21(28-26(35)25(34)27(36)30(39-28)40-2)17-22(18)16-20-12-10-19(11-13-20)6-5-8-24(33)32-15-4-3-7-23(31)29(37)38/h9-14,17,23,25-28,30,34-36H,3-8,15-16,31H2,1-2H3,(H,32,33)(H,37,38)/t23-,25+,26+,27-,28-,30+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176430
PNG
(US9688710, 29 (2S,3R,4R,5S,6R)-2-(3-(4-chlorobenzy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H23ClO4S/c1-11-3-6-13(10-14(11)9-12-4-7-15(21)8-5-12)19-17(23)16(22)18(24)20(25-19)26-2/h3-8,10,16-20,22-24H,9H2,1-2H3/t16-,17-,18+,19+,20-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176432
PNG
(US9688710, 31 (S)-2-amino-6-(5-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1
Show InChI InChI=1S/C31H44N2O7S/c1-19-10-15-22(29-27(36)26(35)28(37)31(40-29)41-2)18-23(19)17-21-13-11-20(12-14-21)7-3-4-9-25(34)33-16-6-5-8-24(32)30(38)39/h10-15,18,24,26-29,31,35-37H,3-9,16-17,32H2,1-2H3,(H,33,34)(H,38,39)/t24-,26+,27+,28-,29-,31+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176451
PNG
(US9688710, 50 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCC(=O)NC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C30H43NO8S/c1-19-8-13-22(28-26(37)25(36)27(38)29(39-28)40-2)15-23(19)14-21-11-9-20(10-12-21)6-4-3-5-7-24(35)31-30(16-32,17-33)18-34/h8-13,15,25-29,32-34,36-38H,3-7,14,16-18H2,1-2H3,(H,31,35)/t25-,26-,27+,28+,29-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176460
PNG
(US9688710, 59 1-(1-hydroxy-2-methylpropan-2-yl)-3-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCNC(=O)NC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C30H44N2O6S/c1-19-9-14-22(27-25(35)24(34)26(36)28(38-27)39-4)17-23(19)16-21-12-10-20(11-13-21)8-6-5-7-15-31-29(37)32-30(2,3)18-33/h9-14,17,24-28,33-36H,5-8,15-16,18H2,1-4H3,(H2,31,32,37)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176466
PNG
(US9688710, 63 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C31H44N2O6S/c1-19-11-16-22(28-26(36)25(35)27(37)29(39-28)40-4)18-23(19)17-21-14-12-20(13-15-21)9-7-5-6-8-10-24(34)33-31(2,3)30(32)38/h11-16,18,25-29,35-37H,5-10,17H2,1-4H3,(H2,32,38)(H,33,34)/t25-,26-,27+,28+,29-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176485
PNG
(US9688710, 66 tert-butyl(2-(4-(2-chloro-5-((2S,3R,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(=O)OC(C)(C)C)cc2)c1
Show InChI InChI=1S/C26H34ClNO7S/c1-26(2,3)35-25(32)28-11-12-33-18-8-5-15(6-9-18)13-17-14-16(7-10-19(17)27)23-21(30)20(29)22(31)24(34-23)36-4/h5-10,14,20-24,29-31H,11-13H2,1-4H3,(H,28,32)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176521
PNG
(US9688710, 86 N-ethyl-4-(4-(2-methyl-5-((2S,3R,4R,...)
Show SMILES CCNC(=O)CCCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C26H35NO6S/c1-4-27-21(28)6-5-13-32-20-11-8-17(9-12-20)14-19-15-18(10-7-16(19)2)25-23(30)22(29)24(31)26(33-25)34-3/h7-12,15,22-26,29-31H,4-6,13-14H2,1-3H3,(H,27,28)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176522
PNG
(US9688710, 87 N-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CCC(=O)NCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H30ClNO6S/c1-3-19(27)26-10-11-31-17-7-4-14(5-8-17)12-16-13-15(6-9-18(16)25)23-21(29)20(28)22(30)24(32-23)33-2/h4-9,13,20-24,28-30H,3,10-12H2,1-2H3,(H,26,27)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176523
PNG
(US9688710, 148 4-methyl-N-(2-(4-(2-methyl-5-((3R,4...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNC(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C28H39N3O6S/c1-18-4-7-20(26-24(33)23(32)25(34)27(37-26)38-3)17-21(18)16-19-5-8-22(9-6-19)36-15-10-29-28(35)31-13-11-30(2)12-14-31/h4-9,17,23-27,32-34H,10-16H2,1-3H3,(H,29,35)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176538
PNG
(US9688710, 98 1-(4-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCCNC(N)=N)cc2)c1
Show InChI InChI=1S/C25H35N3O5S/c1-15-5-8-17(23-21(30)20(29)22(31)24(33-23)34-2)14-18(15)13-16-6-9-19(10-7-16)32-12-4-3-11-28-25(26)27/h5-10,14,20-24,29-31H,3-4,11-13H2,1-2H3,(H4,26,27,28)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176540
PNG
(US9688710, 100 (3R,4R,5S,6R)-2-(3-(4-(4-((1-hydrox...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C28H41NO5S/c1-18-8-13-21(26-24(32)23(31)25(33)27(34-26)35-4)16-22(18)15-20-11-9-19(10-12-20)7-5-6-14-29-28(2,3)17-30/h8-13,16,23-27,29-33H,5-7,14-15,17H2,1-4H3/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176541
PNG
(US9688710, 101 (3R,4R,5S,6R)-2-(3-(4-(4-((1,3-dihy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(CO)(CO)CO)cc2)c1
Show InChI InChI=1S/C28H41NO7S/c1-18-6-11-21(26-24(34)23(33)25(35)27(36-26)37-2)14-22(18)13-20-9-7-19(8-10-20)5-3-4-12-29-28(15-30,16-31)17-32/h6-11,14,23-27,29-35H,3-5,12-13,15-17H2,1-2H3/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176545
PNG
(US9688710, 105 3-hydroxy-2,2-dimethyl-N-(4-(4-(2-m...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(=O)C(C)(C)CO)cc2)c1
Show InChI InChI=1S/C29H41NO6S/c1-18-8-13-21(26-24(33)23(32)25(34)27(36-26)37-4)16-22(18)15-20-11-9-19(10-12-20)7-5-6-14-30-28(35)29(2,3)17-31/h8-13,16,23-27,31-34H,5-7,14-15,17H2,1-4H3,(H,30,35)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176685
PNG
(US9688710, 110 1-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(N)=N)cc2)c1
Show InChI InChI=1S/C22H28ClN3O5S/c1-32-21-19(29)17(27)18(28)20(31-21)13-4-7-16(23)14(11-13)10-12-2-5-15(6-3-12)30-9-8-26-22(24)25/h2-7,11,17-21,27-29H,8-10H2,1H3,(H4,24,25,26)/t17-,18-,19+,20+,21-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176414
PNG
(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-5)20-25(21)19-23-12-10-22(11-13-23)7-6-8-26(37)34-33(2,3)32(41)36-17-15-35(4)16-18-36/h9-14,20,27-31,38-40H,6-8,15-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176693
PNG
(US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC3(CC3)C(=O)N3CCN(C)CC3)cc2)c1
Show InChI InChI=1S/C33H45N3O6S/c1-21-7-12-24(30-28(39)27(38)29(40)31(42-30)43-3)20-25(21)19-23-10-8-22(9-11-23)5-4-6-26(37)34-33(13-14-33)32(41)36-17-15-35(2)16-18-36/h7-12,20,27-31,38-40H,4-6,13-19H2,1-3H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176695
PNG
(US9688710, 118 tert-butyl 4-(2-methyl-2-(4-(4-(2-m...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)cc2)c1
Show InChI InChI=1S/C37H53N3O8S/c1-23-11-16-26(32-30(43)29(42)31(44)33(47-32)49-7)22-27(23)21-25-14-12-24(13-15-25)9-8-10-28(41)38-37(5,6)34(45)39-17-19-40(20-18-39)35(46)48-36(2,3)4/h11-16,22,29-33,42-44H,8-10,17-21H2,1-7H3,(H,38,41)/t29-,30-,31+,32+,33-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176700
PNG
(US9688710, 123 N-(2-methyl-1-oxo-1-(piperidin-4-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)NC3CCNCC3)cc2)c1
Show InChI InChI=1S/C33H47N3O6S/c1-20-8-13-23(30-28(39)27(38)29(40)31(42-30)43-4)19-24(20)18-22-11-9-21(10-12-22)6-5-7-26(37)36-33(2,3)32(41)35-25-14-16-34-17-15-25/h8-13,19,25,27-31,34,38-40H,5-7,14-18H2,1-4H3,(H,35,41)(H,36,37)/t27-,28-,29+,30+,31-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176702
PNG
(US9688710, 125 2,2-dimethyl-3-((2-(4-(2-methyl-5-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNCC(C)(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C27H38N2O6S/c1-16-5-8-18(24-22(31)21(30)23(32)25(35-24)36-4)14-19(16)13-17-6-9-20(10-7-17)34-12-11-29-15-27(2,3)26(28)33/h5-10,14,21-25,29-32H,11-13,15H2,1-4H3,(H2,28,33)/t21-,22-,23+,24+,25-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176715
PNG
(US9688710, 137 N-(2-methyl-1-oxo-1-(piperazin-1-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1
Show InChI InChI=1S/C32H45N3O6S/c1-20-8-13-23(29-27(38)26(37)28(39)30(41-29)42-4)19-24(20)18-22-11-9-21(10-12-22)6-5-7-25(36)34-32(2,3)31(40)35-16-14-33-15-17-35/h8-13,19,26-30,33,37-39H,5-7,14-18H2,1-4H3,(H,34,36)/t26-,27-,28+,29+,30-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176718
PNG
(US9688710, 140 N-(2-methyl-1-(4-methylpiperidin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(=O)N3CCC(C)CC3)cc2)c1
Show InChI InChI=1S/C34H48N2O7S/c1-21-14-16-36(17-15-21)33(41)34(3,4)35-27(37)7-6-18-42-26-12-9-23(10-13-26)19-25-20-24(11-8-22(25)2)31-29(39)28(38)30(40)32(43-31)44-5/h8-13,20-21,28-32,38-40H,6-7,14-19H2,1-5H3,(H,35,37)/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176723
PNG
(US9688710, 145 (3R,4R,5S,6R)-2-(3-(4-(3-((3-hydrox...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNCC(C)(C)CO)cc2)c1
Show InChI InChI=1S/C28H41NO6S/c1-18-6-9-20(26-24(32)23(31)25(33)27(35-26)36-4)15-21(18)14-19-7-10-22(11-8-19)34-13-5-12-29-16-28(2,3)17-30/h6-11,15,23-27,29-33H,5,12-14,16-17H2,1-4H3/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176737
PNG
(US9688710, 158 (3R,4R,5S,6R)-2-(3-(4-(3-((1,3-dihy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNC(CO)CO)cc2)c1
Show InChI InChI=1S/C26H37NO7S/c1-16-4-7-18(25-23(31)22(30)24(32)26(34-25)35-2)13-19(16)12-17-5-8-21(9-6-17)33-11-3-10-27-20(14-28)15-29/h4-9,13,20,22-32H,3,10-12,14-15H2,1-2H3/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176440
PNG
(US9688710, 39 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)C(N)=O)cc2)c1
Show InChI InChI=1S/C27H36N2O7S/c1-15-6-9-18(25-23(32)22(31)24(33)27(36-25)37-3)14-19(15)13-17-7-10-20(11-8-17)35-12-4-5-21(30)29-16(2)26(28)34/h6-11,14,16,22-25,27,31-33H,4-5,12-13H2,1-3H3,(H2,28,34)(H,29,30)/t16?,22-,23-,24+,25+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176441
PNG
(US9688710, 40 N-(1-hydroxy-2-methylpropan-2-yl)-4-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)CO)cc2)c1
Show InChI InChI=1S/C27H37NO7S/c1-16-6-9-19(26-24(32)23(31)25(33)27(35-26)36-3)14-20(16)13-18-7-10-21(11-8-18)34-12-4-5-22(30)28-17(2)15-29/h6-11,14,17,23-27,29,31-33H,4-5,12-13,15H2,1-3H3,(H,28,30)/t17?,23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176463
PNG
(US9688710, 62 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(=O)N(CCO)CCO)cc2)c1
Show InChI InChI=1S/C27H36ClNO8S/c1-38-27-25(35)23(33)24(34)26(37-27)18-6-9-21(28)19(16-18)15-17-4-7-20(8-5-17)36-14-2-3-22(32)29(10-12-30)11-13-31/h4-9,16,23-27,30-31,33-35H,2-3,10-15H2,1H3/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176479
PNG
(US9688710, 64 N-((S)-1-amino-3-hydroxy-1-oxopropan...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(=O)N[C@@H](CO)C(N)=O)cc2)c1
Show InChI InChI=1S/C26H33ClN2O8S/c1-38-26-23(34)21(32)22(33)24(37-26)15-6-9-18(27)16(12-15)11-14-4-7-17(8-5-14)36-10-2-3-20(31)29-19(13-30)25(28)35/h4-9,12,19,21-24,26,30,32-34H,2-3,10-11,13H2,1H3,(H2,28,35)(H,29,31)/t19-,21+,22+,23-,24-,26+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%