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Patent code US9693997

Compile Data Set for Download or QSAR

Found 356 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65605
PNG
(US9693997, 17)
Show SMILES CC(C)(C)CCN1CCCC(C1)S(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C26H32ClF3N6O2S/c1-25(2,3)10-12-36-11-4-5-19(15-36)39(37,38)18-8-6-16(7-9-18)22-20(26(28,29)30)13-17(14-21(22)27)32-24-33-23(31)34-35-24/h6-9,13-14,19H,4-5,10-12,15H2,1-3H3,(H4,31,32,33,34,35)
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US Patent
n/an/an/an/a 43n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65613
PNG
(US9693997, 23)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1c(F)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C17H17ClFN5O2S/c1-9(2)27(25,26)12-5-3-10(4-6-12)15-13(18)7-11(8-14(15)19)21-17-22-16(20)23-24-17/h3-9H,1-2H3,(H4,20,21,22,23,24)
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n/an/an/an/a 92n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65615
PNG
(US9693997, 25)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)CC3CCCNC3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C21H22ClF3N6O2S/c22-17-9-14(28-20-29-19(26)30-31-20)8-16(21(23,24)25)18(17)13-3-5-15(6-4-13)34(32,33)11-12-2-1-7-27-10-12/h3-6,8-9,12,27H,1-2,7,10-11H2,(H4,26,28,29,30,31)
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n/an/an/an/a 59n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM65616
PNG
(US9693997, 26)
Show SMILES Nc1nc(Nc2cc(Cl)c(c(Cl)c2)-c2ccc(OCCCC#N)cc2)n[nH]1
Show InChI InChI=1S/C18H16Cl2N6O/c19-14-9-12(23-18-24-17(22)25-26-18)10-15(20)16(14)11-3-5-13(6-4-11)27-8-2-1-7-21/h3-6,9-10H,1-2,8H2,(H4,22,23,24,25,26)
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n/an/an/an/a 8n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM65624
PNG
(US9693997, 32)
Show SMILES Nc1nc(Nc2cc(Cl)c(c(Cl)c2)-c2ccc(OCC3CNC3)cc2)n[nH]1
Show InChI InChI=1S/C18H18Cl2N6O/c19-14-5-12(23-18-24-17(21)25-26-18)6-15(20)16(14)11-1-3-13(4-2-11)27-9-10-7-22-8-10/h1-6,10,22H,7-9H2,(H4,21,23,24,25,26)
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n/an/an/an/a 6n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65636
PNG
(US9693997, 41)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3cccc(OC4CCNCC4)c3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C20H20ClF3N6O/c21-16-10-12(27-19-28-18(25)29-30-19)9-15(20(22,23)24)17(16)11-2-1-3-14(8-11)31-13-4-6-26-7-5-13/h1-3,8-10,13,26H,4-7H2,(H4,25,27,28,29,30)
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n/an/an/an/a 166n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65643
PNG
(US9693997, 46)
Show SMILES CS(=O)(=O)Nc1ccc(cc1F)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C15H13Cl2FN6O2S/c1-27(25,26)24-12-3-2-7(4-11(12)18)13-9(16)5-8(6-10(13)17)20-15-21-14(19)22-23-15/h2-6,24H,1H3,(H4,19,20,21,22,23)
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n/an/an/an/a 414n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65654
PNG
(US9693997, 54)
Show SMILES Nc1nc(Nc2ccc(cc2)-c2ccc(NC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)cc2)n[nH]1
Show InChI InChI=1S/C24H28N8O2S/c25-22-30-23(32-31-22)27-17-11-7-15(8-12-17)14-5-9-16(10-6-14)26-20(33)4-2-1-3-19-21-18(13-35-19)28-24(34)29-21/h5-12,18-19,21H,1-4,13H2,(H,26,33)(H2,28,29,34)(H4,25,27,30,31,32)/t18-,19-,21-/m0/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM65654
PNG
(US9693997, 54)
Show SMILES Nc1nc(Nc2ccc(cc2)-c2ccc(NC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)cc2)n[nH]1
Show InChI InChI=1S/C24H28N8O2S/c25-22-30-23(32-31-22)27-17-11-7-15(8-12-17)14-5-9-16(10-6-14)26-20(33)4-2-1-3-19-21-18(13-35-19)28-24(34)29-21/h5-12,18-19,21H,1-4,13H2,(H,26,33)(H2,28,29,34)(H4,25,27,30,31,32)/t18-,19-,21-/m0/s1
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n/an/an/an/a 5.73E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM65656
PNG
(US9693997, 55)
Show SMILES Nc1nc(Nc2ccc(cc2)-c2ccccc2)n[nH]1
Show InChI InChI=1S/C14H13N5/c15-13-17-14(19-18-13)16-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H4,15,16,17,18,19)
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n/an/an/an/a 2.51E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65657
PNG
(US9693997, 56)
Show SMILES CC(C)(C)CCN1CCCC(CS(=O)(=O)c2ccc(cc2)-c2c(Cl)cc(Nc3n[nH]c(N)n3)cc2C(F)(F)F)C1
Show InChI InChI=1S/C27H34ClF3N6O2S/c1-26(2,3)10-12-37-11-4-5-17(15-37)16-40(38,39)20-8-6-18(7-9-20)23-21(27(29,30)31)13-19(14-22(23)28)33-25-34-24(32)35-36-25/h6-9,13-14,17H,4-5,10-12,15-16H2,1-3H3,(H4,32,33,34,35,36)
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n/an/an/an/a 46n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65690
PNG
(US9693997, 75)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1c(F)cc(Nc2nc(N)n[nH]2)cc1C(F)(F)F
Show InChI InChI=1S/C17H16F4N6O2S/c1-27(2)30(28,29)11-5-3-9(4-6-11)14-12(17(19,20)21)7-10(8-13(14)18)23-16-24-15(22)25-26-16/h3-8H,1-2H3,(H4,22,23,24,25,26)
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n/an/an/an/a 164n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65695
PNG
(US9693997, 80)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1c(F)cc(Nc2nc(N)n[nH]2)cc1F
Show InChI InChI=1S/C15H13F2N5O2S/c1-25(23,24)10-4-2-3-8(5-10)13-11(16)6-9(7-12(13)17)19-15-20-14(18)21-22-15/h2-7H,1H3,(H4,18,19,20,21,22)
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US Patent
n/an/an/an/a 286n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65698
PNG
(US9693997, 81)
Show SMILES CNS(=O)(=O)c1cccc(c1)-c1c(F)cc(Nc2nc(N)n[nH]2)cc1C(F)(F)F
Show InChI InChI=1S/C16H14F4N6O2S/c1-22-29(27,28)10-4-2-3-8(5-10)13-11(16(18,19)20)6-9(7-12(13)17)23-15-24-14(21)25-26-15/h2-7,22H,1H3,(H4,21,23,24,25,26)
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n/an/an/an/a 549n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM65720
PNG
(US9693997, 92)
Show SMILES Nc1nc(Nc2cc(Cl)c(c(Cl)c2)-c2cccc(Cl)c2)n[nH]1
Show InChI InChI=1S/C14H10Cl3N5/c15-8-3-1-2-7(4-8)12-10(16)5-9(6-11(12)17)19-14-20-13(18)21-22-14/h1-6H,(H4,18,19,20,21,22)
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n/an/an/an/a 34n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM65771
PNG
(US9693997, 98)
Show SMILES COc1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C15H13Cl2N5O/c1-23-10-4-2-8(3-5-10)13-11(16)6-9(7-12(13)17)19-15-20-14(18)21-22-15/h2-7H,1H3,(H4,18,19,20,21,22)
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n/an/an/an/a 10n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70451
PNG
(US9693997, 112)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C15H14Cl2N6O2S/c1-26(24,25)23-9-4-2-3-8(5-9)13-11(16)6-10(7-12(13)17)19-15-20-14(18)21-22-15/h2-7,23H,1H3,(H4,18,19,20,21,22)
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n/an/an/an/a 48n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70452
PNG
(US9693997, 113)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C17H16Cl2N6O/c1-25(2)15(26)10-5-3-9(4-6-10)14-12(18)7-11(8-13(14)19)21-17-22-16(20)23-24-17/h3-8H,1-2H3,(H4,20,21,22,23,24)
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n/an/an/an/a 79n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM70466
PNG
(US9693997, 123)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C16H16Cl2N6O2S/c1-24(2)27(25,26)11-5-3-9(4-6-11)14-12(17)7-10(8-13(14)18)20-16-21-15(19)22-23-16/h3-8H,1-2H3,(H4,19,20,21,22,23)
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n/an/an/an/a 2n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70472
PNG
(US9693997, 128)
Show SMILES CN(C(=O)OC(C)(C)C)C(C)(C)COc1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C25H30ClF3N6O3/c1-23(2,3)38-22(36)35(6)24(4,5)13-37-16-9-7-14(8-10-16)19-17(25(27,28)29)11-15(12-18(19)26)31-21-32-20(30)33-34-21/h7-12H,13H2,1-6H3,(H4,30,31,32,33,34)
PDB
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US Patent
n/an/an/an/a 11n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70484
PNG
(US9693997, 134)
Show SMILES CC(C)(C)OC(=O)NCCOc1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C22H24ClF3N6O3/c1-21(2,3)35-20(33)28-8-9-34-14-6-4-12(5-7-14)17-15(22(24,25)26)10-13(11-16(17)23)29-19-30-18(27)31-32-19/h4-7,10-11H,8-9H2,1-3H3,(H,28,33)(H4,27,29,30,31,32)
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n/an/an/an/a 81n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70597
PNG
(US9693997, 138)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N6O3/c1-24(2,3)38-23(36)35-10-8-17(9-11-35)37-16-6-4-14(5-7-16)20-18(25(27,28)29)12-15(13-19(20)26)31-22-32-21(30)33-34-22/h4-7,12-13,17H,8-11H2,1-3H3,(H4,30,31,32,33,34)
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n/an/an/an/a 162n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70599
PNG
(US9693997, 139)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(OC4CCNCC4)cc3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C20H20ClF3N6O/c21-16-10-12(27-19-28-18(25)29-30-19)9-15(20(22,23)24)17(16)11-1-3-13(4-2-11)31-14-5-7-26-8-6-14/h1-4,9-10,14,26H,5-8H2,(H4,25,27,28,29,30)
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n/an/an/an/a 42n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70606
PNG
(US9693997, 144)
Show SMILES Nc1nc(Nc2ccc(c(Cl)c2)-c2ccccc2)n[nH]1
Show InChI InChI=1S/C14H12ClN5/c15-12-8-10(17-14-18-13(16)19-20-14)6-7-11(12)9-4-2-1-3-5-9/h1-8H,(H4,16,17,18,19,20)
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n/an/an/an/a 2.92E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM70606
PNG
(US9693997, 144)
Show SMILES Nc1nc(Nc2ccc(c(Cl)c2)-c2ccccc2)n[nH]1
Show InChI InChI=1S/C14H12ClN5/c15-12-8-10(17-14-18-13(16)19-20-14)6-7-11(12)9-4-2-1-3-5-9/h1-8H,(H4,16,17,18,19,20)
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n/an/an/an/a 333n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70612
PNG
(US9693997, 148)
Show SMILES Nc1nc(Nc2ccc(c(Cl)c2)-c2cccc(F)c2)n[nH]1
Show InChI InChI=1S/C14H11ClFN5/c15-12-7-10(18-14-19-13(17)20-21-14)4-5-11(12)8-2-1-3-9(16)6-8/h1-7H,(H4,17,18,19,20,21)
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n/an/an/an/a 3.34E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70628
PNG
(US9693997, 158)
Show SMILES NC(=O)c1cccc(c1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C15H12Cl2N6O/c16-10-5-9(20-15-21-14(19)22-23-15)6-11(17)12(10)7-2-1-3-8(4-7)13(18)24/h1-6H,(H2,18,24)(H4,19,20,21,22,23)
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n/an/an/an/a 539n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70642
PNG
(US9693997, 170)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N3CCCC3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C19H18ClF3N6O2S/c20-15-10-12(25-18-26-17(24)27-28-18)9-14(19(21,22)23)16(15)11-3-5-13(6-4-11)32(30,31)29-7-1-2-8-29/h3-6,9-10H,1-2,7-8H2,(H4,24,25,26,27,28)
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n/an/an/an/a 26n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70646
PNG
(US9693997, 173)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N[C@H]3C[C@H](O)C3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C19H18ClF3N6O3S/c20-15-8-10(25-18-26-17(24)27-28-18)7-14(19(21,22)23)16(15)9-1-3-13(4-2-9)33(31,32)29-11-5-12(30)6-11/h1-4,7-8,11-12,29-30H,5-6H2,(H4,24,25,26,27,28)/t11-,12-
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n/an/an/an/a 19n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70648
PNG
(US9693997, 175)
Show SMILES COc1ccc(cc1S(=O)(=O)NCCO)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C18H18ClF3N6O4S/c1-32-13-3-2-9(6-14(13)33(30,31)24-4-5-29)15-11(18(20,21)22)7-10(8-12(15)19)25-17-26-16(23)27-28-17/h2-3,6-8,24,29H,4-5H2,1H3,(H4,23,25,26,27,28)
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n/an/an/an/a 18n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM70653
PNG
(US9693997, 179)
Show SMILES COc1cc(ccc1S(=O)(=O)NC(C)(C)C)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C20H22ClF3N6O3S/c1-19(2,3)30-34(31,32)15-6-5-10(7-14(15)33-4)16-12(20(22,23)24)8-11(9-13(16)21)26-18-27-17(25)28-29-18/h5-9,30H,1-4H3,(H4,25,26,27,28,29)
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n/an/an/an/a 2n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM70655
PNG
(US9693997, 181)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C18H17ClF3N5O2S/c1-9(2)30(28,29)12-5-3-10(4-6-12)15-13(18(20,21)22)7-11(8-14(15)19)24-17-25-16(23)26-27-17/h3-9H,1-2H3,(H4,23,24,25,26,27)
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n/an/an/an/a 21n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70657
PNG
(US9693997, 183)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N3CCC(F)(F)CC3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C20H18ClF5N6O2S/c21-15-10-12(28-18-29-17(27)30-31-18)9-14(20(24,25)26)16(15)11-1-3-13(4-2-11)35(33,34)32-7-5-19(22,23)6-8-32/h1-4,9-10H,5-8H2,(H4,27,28,29,30,31)
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n/an/an/an/a 48n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70659
PNG
(US9693997, 184)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N[C@H]3CC[C@H](O)CC3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C21H22ClF3N6O3S/c22-17-10-13(27-20-28-19(26)29-30-20)9-16(21(23,24)25)18(17)11-1-7-15(8-2-11)35(33,34)31-12-3-5-14(32)6-4-12/h1-2,7-10,12,14,31-32H,3-6H2,(H4,26,27,28,29,30)/t12-,14-
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n/an/an/an/a 50n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70664
PNG
(US9693997, 189)
Show SMILES CNC(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N6O/c1-23-14(28)9-4-2-8(3-5-9)13-11(17(19,20)21)6-10(7-12(13)18)24-16-25-15(22)26-27-16/h2-7H,1H3,(H,23,28)(H4,22,24,25,26,27)
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n/an/an/an/a 80n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70673
PNG
(US9693997, 197)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3cccc(c3)S(N)(=O)=O)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C15H12ClF3N6O2S/c16-11-6-8(22-14-23-13(20)24-25-14)5-10(15(17,18)19)12(11)7-2-1-3-9(4-7)28(21,26)27/h1-6H,(H2,21,26,27)(H4,20,22,23,24,25)
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n/an/an/an/a 249n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70694
PNG
(US9693997, 213)
Show SMILES CNCCNS(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C18H19ClF3N7O2S/c1-24-6-7-25-32(30,31)12-4-2-10(3-5-12)15-13(18(20,21)22)8-11(9-14(15)19)26-17-27-16(23)28-29-17/h2-5,8-9,24-25H,6-7H2,1H3,(H4,23,26,27,28,29)
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n/an/an/an/a 62n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70715
PNG
(US9693997, 228)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C18H17ClF3N5O2S/c1-9(2)30(28,29)12-5-3-10(4-6-12)15-13(18(20,21)22)7-11(8-14(15)19)24-17-25-16(23)26-27-17/h3-9H,1-2H3,(H4,23,24,25,26,27)
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n/an/an/an/a 42n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70743
PNG
(US9693997, 246)
Show SMILES Nc1n[nH]c(Nc2cc(F)c(-c3ccc(cc3)C(F)(F)F)c(c2)C(F)(F)F)n1
Show InChI InChI=1S/C16H10F7N5/c17-11-6-9(25-14-26-13(24)27-28-14)5-10(16(21,22)23)12(11)7-1-3-8(4-2-7)15(18,19)20/h1-6H,(H4,24,25,26,27,28)
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n/an/an/an/a 3.54E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70749
PNG
(US9693997, 251)
Show SMILES CC(C)C(=O)Nc1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-9(2)16(27)22-11-5-3-10(4-6-11)15-13(19)7-12(8-14(15)20)23-18-24-17(21)25-26-18/h3-9H,1-2H3,(H,22,27)(H4,21,23,24,25,26)
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n/an/an/an/a 41n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM70752
PNG
(US9693997, 254)
Show SMILES Nc1n[nH]c(Nc2cc(Cl)c(c(Cl)c2)-c2ccc3NC(=O)Cc3c2)n1
Show InChI InChI=1S/C16H12Cl2N6O/c17-10-5-9(20-16-22-15(19)23-24-16)6-11(18)14(10)7-1-2-12-8(3-7)4-13(25)21-12/h1-3,5-6H,4H2,(H,21,25)(H4,19,20,22,23,24)
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n/an/an/an/a 3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


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More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70775
PNG
(US9693997, 270)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(OC[C@@H]4CCCN4)cc3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C20H20ClF3N6O/c21-16-9-13(27-19-28-18(25)29-30-19)8-15(20(22,23)24)17(16)11-3-5-14(6-4-11)31-10-12-2-1-7-26-12/h3-6,8-9,12,26H,1-2,7,10H2,(H4,25,27,28,29,30)/t12-/m0/s1
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n/an/an/an/a 117n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70779
PNG
(US9693997, 274)
Show SMILES CC1(C)OCC(COc2ccc(cc2)-c2c(Cl)cc(Nc3n[nH]c(N)n3)cc2Cl)O1
Show InChI InChI=1S/C20H21Cl2N5O3/c1-20(2)29-10-14(30-20)9-28-13-5-3-11(4-6-13)17-15(21)7-12(8-16(17)22)24-19-25-18(23)26-27-19/h3-8,14H,9-10H2,1-2H3,(H4,23,24,25,26,27)
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n/an/an/an/a 121n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70793
PNG
(US9693997, 283)
Show SMILES Nc1nc(Nc2cc(Cl)c(c(Cl)c2)-c2ccc(OCCCN3CCOCC3)cc2)n[nH]1
Show InChI InChI=1S/C21H24Cl2N6O2/c22-17-12-15(25-21-26-20(24)27-28-21)13-18(23)19(17)14-2-4-16(5-3-14)31-9-1-6-29-7-10-30-11-8-29/h2-5,12-13H,1,6-11H2,(H4,24,25,26,27,28)
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n/an/an/an/a 523n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM70797
PNG
(US9693997, 287)
Show SMILES Nc1nc(Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2F)n[nH]1
Show InChI InChI=1S/C14H10Cl2FN5/c15-9-5-7(19-14-20-13(18)21-22-14)6-10(16)12(9)8-3-1-2-4-11(8)17/h1-6H,(H4,18,19,20,21,22)
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n/an/an/an/a 5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM70800
PNG
(US9693997, 290)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C16H14ClF3N6O2S/c1-29(27,28)26-9-4-2-3-8(5-9)13-11(16(18,19)20)6-10(7-12(13)17)22-15-23-14(21)24-25-15/h2-7,26H,1H3,(H4,21,22,23,24,25)
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n/an/an/an/a 149n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65584
PNG
(US9693997, 3)
Show SMILES CC(C)(C)OC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N6O4S/c1-23(2,3)38-20(35)18-5-4-10-34(18)39(36,37)15-8-6-13(7-9-15)19-16(24(26,27)28)11-14(12-17(19)25)30-22-31-21(29)32-33-22/h6-9,11-12,18H,4-5,10H2,1-3H3,(H4,29,30,31,32,33)/t18-/m0/s1
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n/an/an/an/a 5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65585
PNG
(US9693997, 4)
Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)C3CCN(CCC(F)(F)F)CC3)c(c2)C(F)(F)F)n[nH]1
Show InChI InChI=1S/C23H23ClF6N6O2S/c24-18-12-14(32-21-33-20(31)34-35-21)11-17(23(28,29)30)19(18)13-1-3-15(4-2-13)39(37,38)16-5-8-36(9-6-16)10-7-22(25,26)27/h1-4,11-12,16H,5-10H2,(H4,31,32,33,34,35)
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n/an/an/an/a 5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65590
PNG
(US9693997, 8)
Show SMILES CC(C)(C)NC(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C19H20Cl2N6O/c1-19(2,3)25-16(28)11-6-4-10(5-7-11)15-13(20)8-12(9-14(15)21)23-18-24-17(22)26-27-18/h4-9H,1-3H3,(H,25,28)(H4,22,23,24,26,27)
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n/an/an/an/a 13n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM65591
PNG
(US9693997, 9)
Show SMILES CCCCC(=O)Nc1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1Cl
Show InChI InChI=1S/C19H20Cl2N6O/c1-2-3-4-16(28)23-12-7-5-11(6-8-12)17-14(20)9-13(10-15(17)21)24-19-25-18(22)26-27-19/h5-10H,2-4H2,1H3,(H,23,28)(H4,22,24,25,26,27)
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n/an/an/an/a 14n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%