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Patent code US9695118

Compile Data Set for Download or QSAR

Found 394 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88314
PNG
(US9695118, 202)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](CNC)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-5-4-18(25)8-17(22)12-31-23(33)16-9-20(24(27,28)29)19(21(26)10-16)14-32-7-6-15(13-32)11-30-2/h4-5,8-10,15,30H,3,6-7,11-14H2,1-2H3,(H,31,33)/t15-/m0/s1
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US Patent
n/an/a 4.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77638
PNG
(US9695118, 161)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](N)C2)c(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27ClF3N3O4S/c1-2-35(32,33)21-8-7-18(24)10-17(21)12-29-22(31)15-5-6-16(20(11-15)34-23(25,26)27)13-30-9-3-4-19(28)14-30/h5-8,10-11,19H,2-4,9,12-14,28H2,1H3,(H,29,31)/t19-/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88312
PNG
(US9695118, 200)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88311
PNG
(US9695118, 199)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-6-5-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77182
PNG
(US9695118, 22)
Show SMILES CCSc1ccc(F)cc1NNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H14F4N2OS/c1-2-24-14-7-6-12(17)9-13(14)21-22-15(23)10-4-3-5-11(8-10)16(18,19)20/h3-9,21H,2H2,1H3,(H,22,23)
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n/an/a 9n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88242
PNG
(US9695118, 633)
Show SMILES CCS(=O)(=O)c1c(C)cc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-4-37(35,36)23-15(2)8-18(26)9-17(23)12-32-24(34)16-10-21(25(28,29)30)20(22(27)11-16)14-33-7-5-6-19(13-33)31-3/h8-11,19,31H,4-7,12-14H2,1-3H3,(H,32,34)/t19-/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88316
PNG
(US9695118, 222)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CCC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26BrClF3N3O3S/c1-2-35(33,34)21-6-5-16(25)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(24)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50080409
PNG
(CHEMBL3422020 | US9695118, 43)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H27ClF3N3O3S/c1-3-34(32,33)21-7-6-19(24)12-18(21)14-28-22(31)16-4-5-17(20(13-16)23(25,26)27)15-30-10-8-29(2)9-11-30/h4-7,12-13H,3,8-11,14-15H2,1-2H3,(H,28,31)
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n/an/a 9.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77664
PNG
(US9695118, 192)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](C2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-4-36(34,35)22-6-5-17(25)9-16(22)12-30-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-7-18(13-32)31(2)3/h5-6,9-11,18H,4,7-8,12-14H2,1-3H3,(H,30,33)/t18-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88310
PNG
(US9695118, 198)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88309
PNG
(US9695118, 197)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-6-5-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77663
PNG
(US9695118, 191)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H24Cl2F3N3O3S/c1-2-34(32,33)20-4-3-15(23)7-14(20)10-29-21(31)13-8-18(22(25,26)27)17(19(24)9-13)12-30-6-5-16(28)11-30/h3-4,7-9,16H,2,5-6,10-12,28H2,1H3,(H,29,31)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88313
PNG
(US9695118, 201)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](CN)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-4-3-17(24)7-16(21)11-30-22(32)15-8-19(23(26,27)28)18(20(25)9-15)13-31-6-5-14(10-29)12-31/h3-4,7-9,14H,2,5-6,10-13,29H2,1H3,(H,30,32)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88317
PNG
(US9695118, 223 | US9695118, 229)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CC[C@@H](CNC)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28BrClF3N3O3S/c1-3-36(34,35)22-5-4-18(26)8-17(22)12-31-23(33)16-9-20(24(27,28)29)19(21(25)10-16)14-32-7-6-15(13-32)11-30-2/h4-5,8-10,15,30H,3,6-7,11-14H2,1-2H3,(H,31,33)/t15-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88267
PNG
(US9695118, 683)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCOC3(CNC3)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H26Cl2F3N3O4S/c1-2-37(34,35)21-4-3-17(25)7-16(21)10-31-22(33)15-8-19(24(27,28)29)18(20(26)9-15)11-32-5-6-36-23(14-32)12-30-13-23/h3-4,7-9,30H,2,5-6,10-14H2,1H3,(H,31,33)
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88276
PNG
(US9695118, 707)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCCC3(CCCCN3)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H32Cl2F3N3O3S/c1-2-39(37,38)24-7-6-20(28)12-19(24)15-33-25(36)18-13-22(27(30,31)32)21(23(29)14-18)16-35-11-5-9-26(17-35)8-3-4-10-34-26/h6-7,12-14,34H,2-5,8-11,15-17H2,1H3,(H,33,36)
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77680
PNG
(US9695118, 208)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-4-37(35,36)23-8-7-18(26)10-17(23)13-31-24(34)16-11-21(25(28,29)30)20(22(27)12-16)15-33-9-5-6-19(14-33)32(2)3/h7-8,10-12,19H,4-6,9,13-15H2,1-3H3,(H,31,34)/t19-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77688
PNG
(US9695118, 220 | US9695118, 221)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CC[C@@H](CN)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26BrClF3N3O3S/c1-2-35(33,34)21-4-3-17(25)7-16(21)11-30-22(32)15-8-19(23(26,27)28)18(20(24)9-15)13-31-6-5-14(10-29)12-31/h3-4,7-9,14H,2,5-6,10-13,29H2,1H3,(H,30,32)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88308
PNG
(US9695118, 196)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-3-35(33,34)21-5-4-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-6-17(12-31)29-2/h4-5,8-10,17,29H,3,6-7,11-13H2,1-2H3,(H,30,32)/t17-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88272
PNG
(US9695118, 702)
Show SMILES CCS(=O)(=O)c1ccc(C)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O3S/c1-4-36(34,35)23-8-7-16(2)10-18(23)13-31-24(33)17-11-21(25(27,28)29)20(22(26)12-17)15-32-9-5-6-19(14-32)30-3/h7-8,10-12,19,30H,4-6,9,13-15H2,1-3H3,(H,31,33)/t19-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88151
PNG
(US9695118, 410)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NCCN)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31Cl2F3N4O3S/c1-2-38(36,37)23-6-5-18(26)10-17(23)13-33-24(35)16-11-21(25(28,29)30)20(22(27)12-16)15-34-9-3-4-19(14-34)32-8-7-31/h5-6,10-12,19,32H,2-4,7-9,13-15,31H2,1H3,(H,33,35)/t19-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88299
PNG
(US9695118, 86)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCCC[C@@H]2NC(=O)CNC)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H32ClF3N4O4S/c1-3-39(37,38)22-10-9-20(27)12-19(22)14-32-25(36)17-7-8-18(21(13-17)26(28,29)30)16-34-11-5-4-6-23(34)33-24(35)15-31-2/h7-10,12-13,23,31H,3-6,11,14-16H2,1-2H3,(H,32,36)(H,33,35)/t23-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77364
PNG
(US9695118, 92)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H29ClF3N3O3S/c1-3-35(33,34)22-9-8-19(25)11-18(22)13-30-23(32)16-6-7-17(21(12-16)24(26,27)28)14-31-10-4-5-20(15-31)29-2/h6-9,11-12,20,29H,3-5,10,13-15H2,1-2H3,(H,30,32)/t20-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77248
PNG
(US9695118, 44)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCN(CC2)C(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O3S/c1-4-36(34,35)23-8-7-21(26)13-20(23)15-30-24(33)18-5-6-19(22(14-18)25(27,28)29)16-31-9-11-32(12-10-31)17(2)3/h5-8,13-14,17H,4,9-12,15-16H2,1-3H3,(H,30,33)
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n/an/a 12n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88158
PNG
(US9695118, 428)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCCC[C@@H]2CN)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-2-36(34,35)22-7-6-17(25)9-16(22)13-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-3-5-18(32)12-30/h6-7,9-11,18H,2-5,8,12-14,30H2,1H3,(H,31,33)/t18-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88155
PNG
(US9695118, 423)
Show SMILES CCN[C@H]1CCCN(Cc2c(Cl)cc(cc2C(F)(F)F)C(=O)NCc2cc(Cl)ccc2S(=O)(=O)CC)C1
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-3-31-19-6-5-9-33(14-19)15-20-21(25(28,29)30)11-16(12-22(20)27)24(34)32-13-17-10-18(26)7-8-23(17)37(35,36)4-2/h7-8,10-12,19,31H,3-6,9,13-15H2,1-2H3,(H,32,34)/t19-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77255
PNG
(US9695118, 52)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H25ClF3N3O3S/c1-2-33(31,32)20-6-5-17(23)9-16(20)11-28-21(30)14-3-4-15(19(10-14)22(24,25)26)12-29-8-7-18(27)13-29/h3-6,9-10,18H,2,7-8,11-13,27H2,1H3,(H,28,30)/t18-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77681
PNG
(US9695118, 209)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC(C)=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H28Cl2F3N3O4S/c1-3-38(36,37)23-7-6-18(26)9-17(23)12-31-24(35)16-10-21(25(28,29)30)20(22(27)11-16)14-33-8-4-5-19(13-33)32-15(2)34/h6-7,9-11,19H,3-5,8,12-14H2,1-2H3,(H,31,35)(H,32,34)/t19-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88240
PNG
(US9695118, 632)
Show SMILES CCS(=O)(=O)c1c(C)cc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O3S/c1-4-36(34,35)23-16(2)10-20(26)11-19(23)13-31-24(33)17-7-8-18(22(12-17)25(27,28)29)14-32-9-5-6-21(15-32)30-3/h7-8,10-12,21,30H,4-6,9,13-15H2,1-3H3,(H,31,33)/t21-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77673
PNG
(US9695118, 203)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](C2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-4-37(35,36)23-8-7-18(26)10-17(23)13-31-24(34)16-11-21(25(28,29)30)20(22(27)12-16)15-33-9-5-6-19(14-33)32(2)3/h7-8,10-12,19H,4-6,9,13-15H2,1-3H3,(H,31,34)/t19-/m1/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88324
PNG
(US9695118, 258)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(OC(F)(F)F)c1
Show InChI InChI=1S/C24H28Cl2F3N3O4S/c1-3-37(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(26)19(21(11-15)36-24(27,28)29)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88211
PNG
(US9695118, 571)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(C#N)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N4O3S/c1-3-37(35,36)23-7-6-19(26)10-18(23)13-32-24(34)16-9-17(12-30)21(22(11-16)25(27,28)29)15-33-8-4-5-20(14-33)31-2/h6-7,9-11,20,31H,3-5,8,13-15H2,1-2H3,(H,32,34)/t20-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88253
PNG
(US9695118, 651)
Show SMILES CN[C@H]1CCCN(Cc2c(Cl)cc(cc2C(F)(F)F)C(=O)NCc2cc(Cl)ccc2S(=O)(=O)C2CCCC2)C1
Show InChI InChI=1S/C27H32Cl2F3N3O3S/c1-33-20-5-4-10-35(15-20)16-22-23(27(30,31)32)12-17(13-24(22)29)26(36)34-14-18-11-19(28)8-9-25(18)39(37,38)21-6-2-3-7-21/h8-9,11-13,20-21,33H,2-7,10,14-16H2,1H3,(H,34,36)/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77645
PNG
(US9695118, 170)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@@H](C2)NC)c(OC(F)(F)F)c1
Show InChI InChI=1S/C24H29ClF3N3O4S/c1-3-36(33,34)22-9-8-19(25)11-18(22)13-30-23(32)16-6-7-17(21(12-16)35-24(26,27)28)14-31-10-4-5-20(15-31)29-2/h6-9,11-12,20,29H,3-5,10,13-15H2,1-2H3,(H,30,32)/t20-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77688
PNG
(US9695118, 220 | US9695118, 221)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CC[C@@H](CN)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26BrClF3N3O3S/c1-2-35(33,34)21-4-3-17(25)7-16(21)11-30-22(32)15-8-19(23(26,27)28)18(20(24)9-15)13-31-6-5-14(10-29)12-31/h3-4,7-9,14H,2,5-6,10-13,29H2,1H3,(H,30,32)/t14-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88215
PNG
(US9695118, 575)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(C#N)c(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N4O3S/c1-3-36(34,35)22-5-4-19(25)11-18(22)14-30-23(33)16-10-17(13-29)20(21(12-16)24(26,27)28)15-32-8-6-31(2)7-9-32/h4-5,10-12H,3,6-9,14-15H2,1-2H3,(H,30,33)
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n/an/a 16n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77233
PNG
(US9695118, 42)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCNCC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H25ClF3N3O3S/c1-2-33(31,32)20-6-5-18(23)11-17(20)13-28-21(30)15-3-4-16(19(12-15)22(24,25)26)14-29-9-7-27-8-10-29/h3-6,11-12,27H,2,7-10,13-14H2,1H3,(H,28,30)
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88342
PNG
(US9695118, 400)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC(=O)CCCCN)c(c1)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N4O4S/c1-2-42(40,41)25-9-8-20(29)12-19(25)15-35-27(39)18-13-23(28(31,32)33)22(24(30)14-18)17-37-11-5-6-21(16-37)36-26(38)7-3-4-10-34/h8-9,12-14,21H,2-7,10-11,15-17,34H2,1H3,(H,35,39)(H,36,38)/t21-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88176
PNG
(US9695118, 460)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H24Cl2F3N3O3S/c1-2-34(32,33)20-4-3-15(23)7-14(20)10-29-21(31)13-8-18(22(25,26)27)17(19(24)9-13)12-30-6-5-16(28)11-30/h3-4,7-9,16H,2,5-6,10-12,28H2,1H3,(H,29,31)/t16-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88250
PNG
(US9695118, 643)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC2CCC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H32Cl2F3N3O3S/c1-2-39(37,38)25-9-8-19(28)11-18(25)14-33-26(36)17-12-23(27(30,31)32)22(24(29)13-17)16-35-10-4-7-21(15-35)34-20-5-3-6-20/h8-9,11-13,20-21,34H,2-7,10,14-16H2,1H3,(H,33,36)/t21-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88338
PNG
(US9695118, 396 | US9695118, 397)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC(=O)C2CCCCN2)c(c1)C(F)(F)F
Show InChI InChI=1S/C29H35Cl2F3N4O4S/c1-2-43(41,42)26-9-8-20(30)12-19(26)15-36-27(39)18-13-23(29(32,33)34)22(24(31)14-18)17-38-11-5-6-21(16-38)37-28(40)25-7-3-4-10-35-25/h8-9,12-14,21,25,35H,2-7,10-11,15-17H2,1H3,(H,36,39)(H,37,40)/t21-,25?/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88197
PNG
(US9695118, 513)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CCNCC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H24BrClF3N3O3S/c1-2-34(32,33)20-4-3-16(24)9-15(20)12-29-21(31)14-10-18(22(25,26)27)17(19(23)11-14)13-30-7-5-28-6-8-30/h3-4,9-11,28H,2,5-8,12-13H2,1H3,(H,29,31)
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n/an/a 17n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77282
PNG
(US9695118, 55)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@H](C2)NS(C)(=O)=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H27ClF3N3O5S2/c1-3-37(34,35)21-7-6-18(24)10-17(21)12-28-22(31)15-4-5-16(20(11-15)23(25,26)27)13-30-9-8-19(14-30)29-36(2,32)33/h4-7,10-11,19,29H,3,8-9,12-14H2,1-2H3,(H,28,31)/t19-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77322
PNG
(US9695118, 67)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H25ClF3N3O3S/c1-2-33(31,32)20-6-5-17(23)9-16(20)11-28-21(30)14-3-4-15(19(10-14)22(24,25)26)12-29-8-7-18(27)13-29/h3-6,9-10,18H,2,7-8,11-13,27H2,1H3,(H,28,30)/t18-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88285
PNG
(US9695118, 745)
Show SMILES CCS(=O)(=O)c1cc(OC)c(Cl)cc1NNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H29Cl2F3N4O4S/c1-4-38(35,36)22-11-21(37-3)19(26)10-20(22)31-32-23(34)14-8-17(24(27,28)29)16(18(25)9-14)13-33-7-5-6-15(12-33)30-2/h8-11,15,30-31H,4-7,12-13H2,1-3H3,(H,32,34)/t15-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88218
PNG
(US9695118, 583)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(C)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O3S/c1-4-36(34,35)23-8-7-19(26)11-18(23)13-31-24(33)17-10-16(2)21(22(12-17)25(27,28)29)15-32-9-5-6-20(14-32)30-3/h7-8,10-12,20,30H,4-6,9,13-15H2,1-3H3,(H,31,33)/t20-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77670
PNG
(US9695118, 194)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](C2)NS(C)(=O)=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O5S2/c1-3-38(35,36)21-5-4-16(24)8-15(21)11-29-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-6-17(12-31)30-37(2,33)34/h4-5,8-10,17,30H,3,6-7,11-13H2,1-2H3,(H,29,32)/t17-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77368
PNG
(US9695118, 94)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@@H](CN)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H27ClF3N3O3S/c1-2-34(32,33)21-6-5-19(24)9-18(21)12-29-22(31)16-3-4-17(20(10-16)23(25,26)27)14-30-8-7-15(11-28)13-30/h3-6,9-10,15H,2,7-8,11-14,28H2,1H3,(H,29,31)/t15-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77658
PNG
(US9695118, 182)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCNCC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H24Cl2F3N3O3S/c1-2-34(32,33)20-4-3-16(23)9-15(20)12-29-21(31)14-10-18(22(25,26)27)17(19(24)11-14)13-30-7-5-28-6-8-30/h3-4,9-11,28H,2,5-8,12-13H2,1H3,(H,29,31)
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88257
PNG
(US9695118, 656)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)C(=O)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H28Cl2F3N3O4S/c1-3-38(36,37)22-7-6-18(26)9-17(22)12-32-24(35)16-10-20(25(28,29)30)19(21(27)11-16)14-33-8-4-5-15(13-33)23(34)31-2/h6-7,9-11,15H,3-5,8,12-14H2,1-2H3,(H,31,34)(H,32,35)/t15-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%