BindingDB logo
myBDB logout

Patent code US9695128

Compile Data Set for Download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88359
PNG
(US9695128, 9)
Show SMILES Fc1cc(cc(F)c1N1C(=O)C2Cc3ccccc3CN2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C25H16F2N2O2/c26-20-12-17(11-10-16-6-2-1-3-7-16)13-21(27)23(20)29-24(30)22-14-18-8-4-5-9-19(18)15-28(22)25(29)31/h1-9,12-13,22H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 56n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88363
PNG
(US9695128, 13)
Show SMILES CC(C)N1C(=O)N(C(=O)C11COC1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C22H18F2N2O3/c1-14(2)26-21(28)25(20(27)22(26)12-29-13-22)19-17(23)10-16(11-18(19)24)9-8-15-6-4-3-5-7-15/h3-7,10-11,14H,12-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 230n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88355
PNG
(US9695128, 5)
Show SMILES Fc1cc(cc(F)c1N1C(=O)C2Cc3ccccc3N2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C24H14F2N2O2/c25-18-12-16(11-10-15-6-2-1-3-7-15)13-19(26)22(18)28-23(29)21-14-17-8-4-5-9-20(17)27(21)24(28)30/h1-9,12-13,21H,14H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 188n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88356
PNG
(US9695128, 6)
Show SMILES Fc1cc(cc(F)c1N1C(=O)C2CCc3ccccc3N2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C25H16F2N2O2/c26-19-14-17(11-10-16-6-2-1-3-7-16)15-20(27)23(19)29-24(30)22-13-12-18-8-4-5-9-21(18)28(22)25(29)31/h1-9,14-15,22H,12-13H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 74n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88361
PNG
(US9695128, 11)
Show SMILES CC1CCCC2N1C(=O)N(C2=O)c1c(F)cc(cc1Cl)C#Cc1cccnc1
Show InChI InChI=1S/C21H17ClFN3O2/c1-13-4-2-6-18-20(27)26(21(28)25(13)18)19-16(22)10-15(11-17(19)23)8-7-14-5-3-9-24-12-14/h3,5,9-13,18H,2,4,6H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 180n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM77241
PNG
(US9695128, 1)
Show SMILES CC(C)N1CC(=O)N(C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C20H16F2N2O2/c1-13(2)23-12-18(25)24(20(23)26)19-16(21)10-15(11-17(19)22)9-8-14-6-4-3-5-7-14/h3-7,10-11,13H,12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 441n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88354
PNG
(US9695128, 4)
Show SMILES CC1COCC2N1C(=O)N(C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C21H16F2N2O3/c1-13-11-28-12-18-20(26)25(21(27)24(13)18)19-16(22)9-15(10-17(19)23)8-7-14-5-3-2-4-6-14/h2-6,9-10,13,18H,11-12H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 204n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88353
PNG
(US9695128, 3)
Show SMILES CC(C)N1C(=O)N(C(=O)C1(C)C)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C22H20F2N2O2/c1-14(2)26-21(28)25(20(27)22(26,3)4)19-17(23)12-16(13-18(19)24)11-10-15-8-6-5-7-9-15/h5-9,12-14H,1-4H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 286n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88357
PNG
(US9695128, 7)
Show SMILES CC1(C)N(C(=O)N(C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H18F2N2O2/c1-25(2)23(30)28(24(31)29(25)19-11-7-4-8-12-19)22-20(26)15-18(16-21(22)27)14-13-17-9-5-3-6-10-17/h3-12,15-16H,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 242n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88360
PNG
(US9695128, 10)
Show SMILES CC1CCCC2N1C(=O)N(C2=O)c1ccc(cc1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C22H19ClN2O2/c1-15-6-5-9-20-21(26)25(22(27)24(15)20)19-13-12-17(14-18(19)23)11-10-16-7-3-2-4-8-16/h2-4,7-8,12-15,20H,5-6,9H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 256n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88362
PNG
(US9695128, 12)
Show SMILES Fc1cc(cc(F)c1N1C(=O)CN(C2CC2)C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C20H14F2N2O2/c21-16-10-14(7-6-13-4-2-1-3-5-13)11-17(22)19(16)24-18(25)12-23(20(24)26)15-8-9-15/h1-5,10-11,15H,8-9,12H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 370n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88358
PNG
(US9695128, 8)
Show SMILES CC(C)(C)N1CC(=O)N(C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C21H18F2N2O2/c1-21(2,3)24-13-18(26)25(20(24)27)19-16(22)11-15(12-17(19)23)10-9-14-7-5-4-6-8-14/h4-8,11-12H,13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 222n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM88352
PNG
(US9695128, 2)
Show SMILES CC(C)N1C(C)C(=O)N(C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C21H18F2N2O2/c1-13(2)24-14(3)20(26)25(21(24)27)19-17(22)11-16(12-18(19)23)10-9-15-7-5-4-6-8-15/h4-8,11-14H,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 104n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%