BindingDB logo
myBDB logout

Patent code US9695132

Compile Data Set for Download or QSAR
Found 194 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88559
PNG
(US9695132, I-1)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C33H31Cl2N7O5/c1-5-26(43)37-21-11-9-10-19(14-21)17-42-31-20(16-36-32(40-31)39-23-13-8-7-12-22(23)38-27(44)6-2)18-41(33(42)45)30-28(34)24(46-3)15-25(47-4)29(30)35/h6-16H,2,5,17-18H2,1,3-4H3,(H,37,43)(H,38,44)(H,36,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88560
PNG
(US9695132, I-2 | US9695132, I-65)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91650
PNG
(US9695132, I-56)
Show SMILES CCN1CCC(=CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H35N7O4/c1-6-28(39)33-27-14-21(20-10-12-37(7-2)13-11-20)8-9-26(27)34-30-32-18-22-19-38(31(40)36(3)29(22)35-30)23-15-24(41-4)17-25(16-23)42-5/h6,8-10,14-18H,1,7,11-13,19H2,2-5H3,(H,33,39)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91652
PNG
(US9695132, I-58)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCC(O)CO)C1=O
Show InChI InChI=1S/C27H30N6O6/c1-4-24(36)29-22-7-5-6-8-23(22)30-26-28-14-17-15-33(18-11-20(38-2)13-21(12-18)39-3)27(37)32(25(17)31-26)10-9-19(35)16-34/h4-8,11-14,19,34-35H,1,9-10,15-16H2,2-3H3,(H,29,36)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92457
PNG
(US9695132, I-77)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)-c3cnn(C)c3)nc2N(C)C1=O
Show InChI InChI=1S/C28H28N8O4/c1-6-25(37)31-24-9-17(18-14-30-34(2)15-18)7-8-23(24)32-27-29-13-19-16-36(28(38)35(3)26(19)33-27)20-10-21(39-4)12-22(11-20)40-5/h6-15H,1,16H2,2-5H3,(H,31,37)(H,29,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92746
PNG
(US9695132, I-91)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3nccs3)C2=O)c1Cl
Show InChI InChI=1S/C27H23Cl2N7O4S/c1-4-20(37)32-16-7-5-6-8-17(16)33-26-31-12-15-13-35(24-22(28)18(39-2)11-19(40-3)23(24)29)27(38)36(25(15)34-26)14-21-30-9-10-41-21/h4-12H,1,13-14H2,2-3H3,(H,32,37)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94660
PNG
(US9695132, I-98)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CC2)C1=O
Show InChI InChI=1S/C27H28N6O4/c1-4-24(34)29-22-7-5-6-8-23(22)30-26-28-14-18-16-32(19-11-20(36-2)13-21(12-19)37-3)27(35)33(25(18)31-26)15-17-9-10-17/h4-8,11-14,17H,1,9-10,15-16H2,2-3H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101134
PNG
(US9695132, I-109)
Show SMILES COc1cc(OC)c(F)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CC2)C1=O
Show InChI InChI=1S/C27H27FN6O4/c1-4-23(35)30-19-7-5-6-8-20(19)31-26-29-13-17-15-33(21-11-18(37-2)12-22(38-3)24(21)28)27(36)34(25(17)32-26)14-16-9-10-16/h4-8,11-13,16H,1,9-10,14-15H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94679
PNG
(US9695132, I-124)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3cn[nH]c3)C2=O)c1Cl
Show InChI InChI=1S/C27H24Cl2N8O4/c1-4-21(38)33-17-7-5-6-8-18(17)34-26-30-12-16-14-36(24-22(28)19(40-2)9-20(41-3)23(24)29)27(39)37(25(16)35-26)13-15-10-31-32-11-15/h4-12H,1,13-14H2,2-3H3,(H,31,32)(H,33,38)(H,30,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94702
PNG
(US9695132, I-141)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)-c4cnn(C)c4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C28H26Cl2N8O4/c1-6-22(39)33-19-9-15(16-12-32-36(2)13-16)7-8-18(19)34-27-31-11-17-14-38(28(40)37(3)26(17)35-27)25-23(29)20(41-4)10-21(42-5)24(25)30/h6-13H,1,14H2,2-5H3,(H,33,39)(H,31,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM96291
PNG
(US9695132, I-143)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1F
Show InChI InChI=1S/C24H28F2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)/t14-,15+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM97559
PNG
(US9695132, I-145)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)-c4nnn(C)n4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C26H24Cl2N10O4/c1-6-19(39)30-16-9-13(23-33-35-37(3)34-23)7-8-15(16)31-25-29-11-14-12-38(26(40)36(2)24(14)32-25)22-20(27)17(41-4)10-18(42-5)21(22)28/h6-11H,1,12H2,2-5H3,(H,30,39)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98638
PNG
(US9695132, I-151)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)C(=O)NC3CCN(C)CC3)nc2N(C)C1=O
Show InChI InChI=1S/C31H36N8O5/c1-6-27(40)34-26-13-19(29(41)33-21-9-11-37(2)12-10-21)7-8-25(26)35-30-32-17-20-18-39(31(42)38(3)28(20)36-30)22-14-23(43-4)16-24(15-22)44-5/h6-8,13-17,21H,1,9-12,18H2,2-5H3,(H,33,41)(H,34,40)(H,32,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98640
PNG
(US9695132, I-153)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)-c4nnnn4C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C26H24Cl2N10O4/c1-6-19(39)30-16-9-13(24-33-34-35-37(24)3)7-8-15(16)31-25-29-11-14-12-38(26(40)36(2)23(14)32-25)22-20(27)17(41-4)10-18(42-5)21(22)28/h6-11H,1,12H2,2-5H3,(H,30,39)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98736
PNG
(US9695132, I-155)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)nc2nc1N
Show InChI InChI=1S/C24H22N6O3/c1-4-21(31)27-19-7-5-6-8-20(19)28-24-26-13-15-11-18(22(25)29-23(15)30-24)14-9-16(32-2)12-17(10-14)33-3/h4-13H,1H2,2-3H3,(H,27,31)(H3,25,26,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99864
PNG
(US9695132, I-200)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CS(=O)(=O)CC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C30H31F4N5O3/c1-30(2,3)42-29(40)38-13-10-18-6-8-21(15-19(18)11-14-38)35-28-36-27-22(5-4-12-39(27)37-28)23-16-20(26(33)34)7-9-24(23)41-17-25(31)32/h4-9,12,15-16,25-26H,10-11,13-14,17H2,1-3H3,(H,35,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100424
PNG
(US9695132, I-217)
Show SMILES CCN1C(=O)N(Cc2cnc(NC3COCC3NC(=O)C=C)nc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O5/c1-5-17(32)27-13-10-36-11-14(13)28-22-26-8-12-9-31(23(33)30(6-2)21(12)29-22)20-18(24)15(34-3)7-16(35-4)19(20)25/h5,7-8,13-14H,1,6,9-11H2,2-4H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88561
PNG
(US9695132, I-3)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H26Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-15H,1,16-17H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88663
PNG
(US9695132, I-26)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3cccc(N)c3)C2=O)c1Cl
Show InChI InChI=1S/C30H27Cl2N7O4/c1-4-24(40)35-20-10-5-6-11-21(20)36-29-34-14-18-16-38(27-25(31)22(42-2)13-23(43-3)26(27)32)30(41)39(28(18)37-29)15-17-8-7-9-19(33)12-17/h4-14H,1,15-16,33H2,2-3H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88664
PNG
(US9695132, I-27)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(ccc3NC(=O)C=C)-c3cnn(C)c3)nc2N(C)C1=O
Show InChI InChI=1S/C28H28N8O4/c1-6-25(37)31-23-8-7-17(18-14-30-34(2)15-18)9-24(23)32-27-29-13-19-16-36(28(38)35(3)26(19)33-27)20-10-21(39-4)12-22(11-20)40-5/h6-15H,1,16H2,2-5H3,(H,31,37)(H,29,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88671
PNG
(US9695132, I-34)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CC2)C1=O
Show InChI InChI=1S/C26H26N6O4/c1-4-23(33)28-21-7-5-6-8-22(21)29-25-27-14-16-15-31(18-11-19(35-2)13-20(12-18)36-3)26(34)32(17-9-10-17)24(16)30-25/h4-8,11-14,17H,1,9-10,15H2,2-3H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88673
PNG
(US9695132, I-36)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCCN(C2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C33H39N7O6/c1-7-28(41)35-26-12-8-9-13-27(26)36-30-34-18-21-19-39(23-15-24(44-5)17-25(16-23)45-6)31(42)40(29(21)37-30)22-11-10-14-38(20-22)32(43)46-33(2,3)4/h7-9,12-13,15-18,22H,1,10-11,14,19-20H2,2-6H3,(H,35,41)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88685
PNG
(US9695132, I-43)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCCNC2)C1=O
Show InChI InChI=1S/C28H31N7O4/c1-4-25(36)31-23-9-5-6-10-24(23)32-27-30-15-18-17-34(20-12-21(38-2)14-22(13-20)39-3)28(37)35(26(18)33-27)19-8-7-11-29-16-19/h4-6,9-10,12-15,19,29H,1,7-8,11,16-17H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89509
PNG
(US9695132, I-49)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(C)ccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H26N6O4/c1-6-22(32)27-20-8-7-15(2)9-21(20)28-24-26-13-16-14-31(25(33)30(3)23(16)29-24)17-10-18(34-4)12-19(11-17)35-5/h6-13H,1,14H2,2-5H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89510
PNG
(US9695132, I-50)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(ccc3NC(=O)C=C)C(F)(F)F)nc2N(C)C1=O
Show InChI InChI=1S/C25H23F3N6O4/c1-5-21(35)30-19-7-6-15(25(26,27)28)8-20(19)31-23-29-12-14-13-34(24(36)33(2)22(14)32-23)16-9-17(37-3)11-18(10-16)38-4/h5-12H,1,13H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91862
PNG
(US9695132, I-64)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cscn2)C1=O
Show InChI InChI=1S/C27H25N7O4S/c1-4-24(35)30-22-7-5-6-8-23(22)31-26-28-12-17-13-33(19-9-20(37-2)11-21(10-19)38-3)27(36)34(25(17)32-26)14-18-15-39-16-29-18/h4-12,15-16H,1,13-14H2,2-3H3,(H,30,35)(H,28,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92612
PNG
(US9695132, I-114 | US9695132, I-86)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3cscn3)C2=O)c1Cl
Show InChI InChI=1S/C27H23Cl2N7O4S/c1-4-21(37)32-17-7-5-6-8-18(17)33-26-30-10-15-11-35(24-22(28)19(39-2)9-20(40-3)23(24)29)27(38)36(25(15)34-26)12-16-13-41-14-31-16/h4-10,13-14H,1,11-12H2,2-3H3,(H,32,37)(H,30,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92744
PNG
(US9695132, I-89)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3cccc(NS(C)(=O)=O)c3)C2=O)c1Cl
Show InChI InChI=1S/C31H35Cl2N7O6S/c1-5-25(41)35-21-11-6-7-12-22(21)36-30-34-15-19-17-39(28-26(32)23(45-2)14-24(46-3)27(28)33)31(42)40(29(19)37-30)16-18-9-8-10-20(13-18)38-47(4,43)44/h5,8-10,13-15,21-22,38H,1,6-7,11-12,16-17H2,2-4H3,(H,35,41)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94659
PNG
(US9695132, I-97)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cccc(c2)C(N)=O)C1=O
Show InChI InChI=1S/C31H29N7O5/c1-4-27(39)34-25-10-5-6-11-26(25)35-30-33-16-21-18-37(22-13-23(42-2)15-24(14-22)43-3)31(41)38(29(21)36-30)17-19-8-7-9-20(12-19)28(32)40/h4-16H,1,17-18H2,2-3H3,(H2,32,40)(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101110
PNG
(US9695132, I-99)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC(F)F)C1=O
Show InChI InChI=1S/C25H24F2N6O4/c1-4-22(34)29-19-7-5-6-8-20(19)30-24-28-12-15-13-32(16-9-17(36-2)11-18(10-16)37-3)25(35)33(14-21(26)27)23(15)31-24/h4-12,21H,1,13-14H2,2-3H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94682
PNG
(US9695132, I-126)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C22H24Cl2N6O5/c1-5-16(31)26-12-9-35-10-13(12)27-21-25-7-11-8-30(22(32)29(2)20(11)28-21)19-17(23)14(33-3)6-15(34-4)18(19)24/h5-7,12-13H,1,8-10H2,2-4H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94684
PNG
(US9695132, I-127)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)N4CCN(CC4)C(=O)CCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC[C@@H]4SC[C@@H]5NC(=O)N[C@H]45)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C53H72Cl2N12O11S/c1-5-42(68)59-37-29-35(15-16-36(37)60-51-58-31-34-32-67(53(73)64(2)50(34)63-51)49-46(54)39(74-3)30-40(75-4)47(49)55)65-19-21-66(22-20-65)45(71)14-8-13-44(70)57-18-10-24-77-26-28-78-27-25-76-23-9-17-56-43(69)12-7-6-11-41-48-38(33-79-41)61-52(72)62-48/h5,15-16,29-31,38,41,48H,1,6-14,17-28,32-33H2,2-4H3,(H,56,69)(H,57,70)(H,59,68)(H,58,60,63)(H2,61,62,72)/t38-,41-,48-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94687
PNG
(US9695132, I-133)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3ccnc(N)c3)C2=O)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O4/c1-4-23(40)35-18-7-5-6-8-19(18)36-28-34-13-17-15-38(26-24(30)20(42-2)12-21(43-3)25(26)31)29(41)39(27(17)37-28)14-16-9-10-33-22(32)11-16/h4,9-13,18-19H,1,5-8,14-15H2,2-3H3,(H2,32,33)(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94688
PNG
(US9695132, I-134)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3csc(C)n3)C2=O)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4S/c1-5-22(38)33-18-8-6-7-9-19(18)34-27-31-11-16-12-36(25-23(29)20(40-3)10-21(41-4)24(25)30)28(39)37(26(16)35-27)13-17-14-42-15(2)32-17/h5-11,14H,1,12-13H2,2-4H3,(H,33,38)(H,31,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94704
PNG
(US9695132, I-142)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C(C)=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H24Cl2N6O4/c1-13(2)23(34)29-15-8-6-7-9-16(15)30-24-28-11-14-12-33(25(35)32(3)22(14)31-24)21-19(26)17(36-4)10-18(37-5)20(21)27/h6-11H,1,12H2,2-5H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99975
PNG
(US9695132, I-201)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(CC4NC(=O)C=C)c4ccncn4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C26H27Cl2N9O4/c1-5-20(38)32-15-11-36(19-6-7-29-13-31-19)12-16(15)33-25-30-9-14-10-37(26(39)35(2)24(14)34-25)23-21(27)17(40-3)8-18(41-4)22(23)28/h5-9,13,15-16H,1,10-12H2,2-4H3,(H,32,38)(H,30,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100311
PNG
(US9695132, I-204)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(CC4NC(=O)C=C)c4ccn(C)n4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C26H29Cl2N9O4/c1-6-20(38)30-15-12-36(19-7-8-34(2)33-19)13-16(15)31-25-29-10-14-11-37(26(39)35(3)24(14)32-25)23-21(27)17(40-4)9-18(41-5)22(23)28/h6-10,15-16H,1,11-13H2,2-5H3,(H,30,38)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100379
PNG
(US9695132, I-211)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC3COCC3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C23H23Cl2N5O5/c1-5-17(31)27-13-9-35-10-14(13)28-23-26-8-11-6-12(22(32)30(2)21(11)29-23)18-19(24)15(33-3)7-16(34-4)20(18)25/h5-8,13-14H,1,9-10H2,2-4H3,(H,27,31)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100421
PNG
(US9695132, I-215)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(Cc3ccn(C)n3)C2=O)c1Cl
Show InChI InChI=1S/C26H28Cl2N8O5/c1-5-20(37)30-16-12-41-13-17(16)31-25-29-9-14-10-35(23-21(27)18(39-3)8-19(40-4)22(23)28)26(38)36(24(14)32-25)11-15-6-7-34(2)33-15/h5-9,16-17H,1,10-13H2,2-4H3,(H,30,37)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88566
PNG
(US9695132, I-8)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(NC4CCCCC4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C33H37Cl2N7O5/c1-5-26(43)37-21-11-9-10-19(14-21)17-42-31-20(16-36-32(40-31)39-23-13-8-7-12-22(23)38-27(44)6-2)18-41(33(42)45)30-28(34)24(46-3)15-25(47-4)29(30)35/h6,9-11,14-16,22-23H,2,5,7-8,12-13,17-18H2,1,3-4H3,(H,37,43)(H,38,44)(H,36,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88686
PNG
(US9695132, I-44)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cccnc2)C1=O
Show InChI InChI=1S/C29H27N7O4/c1-4-26(37)32-24-9-5-6-10-25(24)33-28-31-16-20-18-35(21-12-22(39-2)14-23(13-21)40-3)29(38)36(27(20)34-28)17-19-8-7-11-30-15-19/h4-16H,1,17-18H2,2-3H3,(H,32,37)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91680
PNG
(US9695132, I-60)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CCN(CC2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C34H41N7O6/c1-7-29(42)36-27-10-8-9-11-28(27)37-31-35-19-23-21-40(24-16-25(45-5)18-26(17-24)46-6)32(43)41(30(23)38-31)20-22-12-14-39(15-13-22)33(44)47-34(2,3)4/h7-11,16-19,22H,1,12-15,20-21H2,2-6H3,(H,36,42)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91873
PNG
(US9695132, I-70)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(C3CCC3)C2=O)c1Cl
Show InChI InChI=1S/C27H32Cl2N6O4/c1-4-21(36)31-17-10-5-6-11-18(17)32-26-30-13-15-14-34(27(37)35(25(15)33-26)16-8-7-9-16)24-22(28)19(38-2)12-20(39-3)23(24)29/h4,12-13,16-18H,1,5-11,14H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91876
PNG
(US9695132, I-75)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-16-8-6-7-9-17(16)28-23-26-12-14-13-31(24(33)30(2)22(14)29-23)18-10-15(34-3)11-19(35-4)21(18)25/h5-12H,1,13H2,2-4H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101115
PNG
(US9695132, I-102)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCF)C1=O
Show InChI InChI=1S/C25H25FN6O4/c1-4-22(33)28-20-7-5-6-8-21(20)29-24-27-14-16-15-32(25(34)31(10-9-26)23(16)30-24)17-11-18(35-2)13-19(12-17)36-3/h4-8,11-14H,1,9-10,15H2,2-3H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94664
PNG
(US9695132, I-113)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CC=CCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H26Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-7,10-11,14-15H,1,8-9,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM96842
PNG
(US9695132, I-144)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccc(F)c(N)c3)C2=O)c1Cl
Show InChI InChI=1S/C30H26Cl2FN7O4/c1-4-24(41)36-20-7-5-6-8-21(20)37-29-35-13-17-15-39(27-25(31)22(43-2)12-23(44-3)26(27)32)30(42)40(28(17)38-29)14-16-9-10-18(33)19(34)11-16/h4-13H,1,14-15,34H2,2-3H3,(H,36,41)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM97690
PNG
(US9695132, I-148)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3cnn(C)c3)C2=O)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-5-22(39)33-18-8-6-7-9-19(18)34-27-31-12-17-15-37(25-23(29)20(41-3)10-21(42-4)24(25)30)28(40)38(26(17)35-27)14-16-11-32-36(2)13-16/h5,10-13,18-19H,1,6-9,14-15H2,2-4H3,(H,33,39)(H,31,34,35)/t18-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98639
PNG
(US9695132, I-152)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3cn[nH]c3)C2=O)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-4-21(38)33-17-7-5-6-8-18(17)34-26-30-12-16-14-36(24-22(28)19(40-2)9-20(41-3)23(24)29)27(39)37(25(16)35-26)13-15-10-31-32-11-15/h4,9-12,17-18H,1,5-8,13-14H2,2-3H3,(H,31,32)(H,33,38)(H,30,34,35)/t17-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100323
PNG
(US9695132, I-206)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(C)C2=O)c1F
Show InChI InChI=1S/C22H24ClFN6O5/c1-5-16(31)26-12-9-35-10-13(12)27-21-25-7-11-8-30(22(32)29(2)20(11)28-21)19-17(23)14(33-3)6-15(34-4)18(19)24/h5-7,12-13H,1,8-10H2,2-4H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100380
PNG
(US9695132, I-212)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(CC3CC3)C2=O)c1Cl
Show InChI InChI=1S/C25H28Cl2N6O5/c1-4-19(34)29-15-11-38-12-16(15)30-24-28-8-14-10-32(25(35)33(23(14)31-24)9-13-5-6-13)22-20(26)17(36-2)7-18(37-3)21(22)27/h4,7-8,13,15-16H,1,5-6,9-12H2,2-3H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100733
PNG
(US9695132, I-223)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CCCC[C@@H]3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H27Cl2N5O4/c1-5-19(33)29-15-8-6-7-9-16(15)30-25-28-12-13-10-14(24(34)32(2)23(13)31-25)20-21(26)17(35-3)11-18(36-4)22(20)27/h5,10-12,15-16H,1,6-9H2,2-4H3,(H,29,33)(H,28,30,31)/t15-,16+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88657
PNG
(US9695132, I-20)
Show SMILES COCCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H38N8O5/c1-6-28(40)33-27-17-22(38-11-9-37(10-12-38)13-14-42-3)7-8-26(27)34-30-32-19-21-20-39(31(41)36(2)29(21)35-30)23-15-24(43-4)18-25(16-23)44-5/h6-8,15-19H,1,9-14,20H2,2-5H3,(H,33,40)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88690
PNG
(US9695132, I-47)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC#N)C2=O)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-4-19(35)30-15-7-5-6-8-16(15)31-24-29-12-14-13-34(25(36)33(10-9-28)23(14)32-24)22-20(26)17(37-2)11-18(38-3)21(22)27/h4,11-12,15-16H,1,5-8,10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91648
PNG
(US9695132, I-54)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H37N7O4/c1-6-28(39)33-27-14-21(20-10-12-37(7-2)13-11-20)8-9-26(27)34-30-32-18-22-19-38(31(40)36(3)29(22)35-30)23-15-24(41-4)17-25(16-23)42-5/h6,8-9,14-18,20H,1,7,10-13,19H2,2-5H3,(H,33,39)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91649
PNG
(US9695132, I-55)
Show SMILES COc1cc(OC)cc(c1)N1Cc2ccc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)cc2N(C)C1=O
Show InChI InChI=1S/C32H36N6O5/c1-6-31(40)34-29-18-24(37-13-11-36(12-14-37)21(2)39)9-10-28(29)33-23-8-7-22-20-38(32(41)35(3)30(22)15-23)25-16-26(42-4)19-27(17-25)43-5/h6-10,15-19,33H,1,11-14,20H2,2-5H3,(H,34,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91651
PNG
(US9695132, I-57)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCC=C)C1=O
Show InChI InChI=1S/C27H28N6O4/c1-5-7-12-32-25-18(17-33(27(32)35)19-13-20(36-3)15-21(14-19)37-4)16-28-26(31-25)30-23-11-9-8-10-22(23)29-24(34)6-2/h5-6,8-11,13-16H,1-2,7,12,17H2,3-4H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91868
PNG
(US9695132, I-67)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NS(=O)(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C23H24N6O5S/c1-5-35(31,32)27-20-9-7-6-8-19(20)25-22-24-13-15-14-29(23(30)28(2)21(15)26-22)16-10-17(33-3)12-18(11-16)34-4/h5-13,27H,1,14H2,2-4H3,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM93378
PNG
(US9695132, I-95)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H28Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)/t14-,15+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101142
PNG
(US9695132, I-116)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C25H22F4N6O4/c1-4-19(36)31-14-7-5-6-8-15(14)32-24-30-10-13-11-34(25(37)35(12-18(26)27)23(13)33-24)22-20(28)16(38-2)9-17(39-3)21(22)29/h4-10,18H,1,11-12H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101139
PNG
(US9695132, I-117)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cn(C)nc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C22H22Cl2N8O4/c1-6-15(33)27-19-12(10-30(2)29-19)26-21-25-8-11-9-32(22(34)31(3)20(11)28-21)18-16(23)13(35-4)7-14(36-5)17(18)24/h6-8,10H,1,9H2,2-5H3,(H,25,26,28)(H,27,29,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94690
PNG
(US9695132, I-135)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccnc(N)c3)C2=O)c1Cl
Show InChI InChI=1S/C29H26Cl2N8O4/c1-4-23(40)35-18-7-5-6-8-19(18)36-28-34-13-17-15-38(26-24(30)20(42-2)12-21(43-3)25(26)31)29(41)39(27(17)37-28)14-16-9-10-33-22(32)11-16/h4-13H,1,14-15H2,2-3H3,(H2,32,33)(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98637
PNG
(US9695132, I-150)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)C(=O)NC4CCN(C)CC4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C31H34Cl2N8O5/c1-6-24(42)36-21-13-17(29(43)35-19-9-11-39(2)12-10-19)7-8-20(21)37-30-34-15-18-16-41(31(44)40(3)28(18)38-30)27-25(32)22(45-4)14-23(46-5)26(27)33/h6-8,13-15,19H,1,9-12,16H2,2-5H3,(H,35,43)(H,36,42)(H,34,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100416
PNG
(US9695132, I-214)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(Cc3c[nH]cn3)C2=O)c1Cl
Show InChI InChI=1S/C25H26Cl2N8O5/c1-4-19(36)31-15-10-40-11-16(15)32-24-29-6-13-8-34(22-20(26)17(38-2)5-18(39-3)21(22)27)25(37)35(23(13)33-24)9-14-7-28-12-30-14/h4-7,12,15-16H,1,8-11H2,2-3H3,(H,28,30)(H,31,36)(H,29,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101306
PNG
(US9695132, I-238)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C21H19Cl2N5O3/c1-27-19-12(10-24-20(26-19)25-13-7-5-4-6-8-13)11-28(21(27)29)18-16(22)14(30-2)9-15(31-3)17(18)23/h4-10H,11H2,1-3H3,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101058
PNG
(US9695132, I-242)
Show SMILES COc1ccc(Nc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(C)c3n2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H23Cl2N5O5/c1-6-20(34)30-17-10-14(36-3)7-8-16(17)31-26-29-12-13-9-15(25(35)33(2)24(13)32-26)21-22(27)18(37-4)11-19(38-5)23(21)28/h6-12H,1H2,2-5H3,(H,30,34)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101064
PNG
(US9695132, I-243)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccc(C)cc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C26H23Cl2N5O4/c1-6-20(34)30-17-9-13(2)7-8-16(17)31-26-29-12-14-10-15(25(35)33(3)24(14)32-26)21-22(27)18(36-4)11-19(37-5)23(21)28/h6-12H,1H2,2-5H3,(H,30,34)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88563
PNG
(US9695132, I-5)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-5-21(31)26-19-8-6-7-9-20(19)27-23-25-13-15-14-30(24(32)29(2)22(15)28-23)16-10-17(33-3)12-18(11-16)34-4/h5-13H,1,14H2,2-4H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88661
PNG
(US9695132, I-24)
Show SMILES COc1cc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)ccc1Cl
Show InChI InChI=1S/C31H27Cl3N6O5/c1-5-25(41)36-20-8-6-7-9-21(20)37-30-35-14-18-16-39(28-26(33)23(44-3)13-24(45-4)27(28)34)31(42)40(29(18)38-30)15-17-10-11-19(32)22(12-17)43-2/h5-14H,1,15-16H2,2-4H3,(H,36,41)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88668
PNG
(US9695132, I-31)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)N3CCCCC3)nc2N(C)C1=O
Show InChI InChI=1S/C29H33N7O4/c1-5-26(37)31-25-15-20(35-11-7-6-8-12-35)9-10-24(25)32-28-30-17-19-18-36(29(38)34(2)27(19)33-28)21-13-22(39-3)16-23(14-21)40-4/h5,9-10,13-17H,1,6-8,11-12,18H2,2-4H3,(H,31,37)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88683
PNG
(US9695132, I-41)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(C)cc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H26N6O4/c1-6-22(32)27-21-9-15(2)7-8-20(21)28-24-26-13-16-14-31(25(33)30(3)23(16)29-24)17-10-18(34-4)12-19(11-17)35-5/h6-13H,1,14H2,2-5H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91647
PNG
(US9695132, I-53)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4N(C)C(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H30Cl2N6O4/c1-6-19(34)31(2)16-10-8-7-9-15(16)29-24-28-12-14-13-33(25(35)32(3)23(14)30-24)22-20(26)17(36-4)11-18(37-5)21(22)27/h6,11-12,15-16H,1,7-10,13H2,2-5H3,(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91871
PNG
(US9695132, I-69)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3cscn3)C2=O)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O4S/c1-4-21(37)32-17-7-5-6-8-18(17)33-26-30-10-15-11-35(24-22(28)19(39-2)9-20(40-3)23(24)29)27(38)36(25(15)34-26)12-16-13-41-14-31-16/h4,9-10,13-14,17-18H,1,5-8,11-12H2,2-3H3,(H,32,37)(H,30,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91875
PNG
(US9695132, I-74)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)-c4cnn(C)c4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C28H26Cl2N8O4/c1-6-22(39)33-18-8-7-15(16-12-32-36(2)13-16)9-19(18)34-27-31-11-17-14-38(28(40)37(3)26(17)35-27)25-23(29)20(41-4)10-21(42-5)24(25)30/h6-13H,1,14H2,2-5H3,(H,33,39)(H,31,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92608
PNG
(US9695132, I-82)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H32Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-7,10-11,14-15,20-21H,1,8-9,12-13,16-17H2,2-3H3,(H,34,39)(H,33,35,36)/t20-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92743
PNG
(US9695132, I-88)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2COC2)C1=O
Show InChI InChI=1S/C26H26N6O5/c1-4-23(33)28-21-7-5-6-8-22(21)29-25-27-12-16-13-31(17-9-19(35-2)11-20(10-17)36-3)26(34)32(24(16)30-25)18-14-37-15-18/h4-12,18H,1,13-15H2,2-3H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92745
PNG
(US9695132, I-90)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cccc(c2)C#N)C1=O
Show InChI InChI=1S/C31H27N7O4/c1-4-28(39)34-26-10-5-6-11-27(26)35-30-33-17-22-19-37(23-13-24(41-2)15-25(14-23)42-3)31(40)38(29(22)36-30)18-21-9-7-8-20(12-21)16-32/h4-15,17H,1,18-19H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94674
PNG
(US9695132, I-121)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cn[nH]c2)C1=O
Show InChI InChI=1S/C27H26N8O4/c1-4-24(36)31-22-7-5-6-8-23(22)32-26-28-14-18-16-34(19-9-20(38-2)11-21(10-19)39-3)27(37)35(25(18)33-26)15-17-12-29-30-13-17/h4-14H,1,15-16H2,2-3H3,(H,29,30)(H,31,36)(H,28,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101146
PNG
(US9695132, I-130)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(CC3CC3)C2=O)c1Cl
Show InChI InChI=1S/C27H26Cl2N6O4/c1-4-21(36)31-17-7-5-6-8-18(17)32-26-30-12-16-14-34(27(37)35(25(16)33-26)13-15-9-10-15)24-22(28)19(38-2)11-20(39-3)23(24)29/h4-8,11-12,15H,1,9-10,13-14H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94691
PNG
(US9695132, I-136)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccn(C)n3)C2=O)c1Cl
Show InChI InChI=1S/C28H26Cl2N8O4/c1-5-22(39)32-18-8-6-7-9-19(18)33-27-31-13-16-14-37(25-23(29)20(41-3)12-21(42-4)24(25)30)28(40)38(26(16)34-27)15-17-10-11-36(2)35-17/h5-13H,1,14-15H2,2-4H3,(H,32,39)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98053
PNG
(US9695132, I-149)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC3=CC(C)N=C3)C2=O)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-5-23(39)34-19-8-6-7-9-20(19)35-28-33-13-18-15-37(26-24(30)21(41-3)11-22(42-4)25(26)31)29(40)38(27(18)36-28)14-17-10-16(2)32-12-17/h5,10-13,16,19-20H,1,6-9,14-15H2,2-4H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99775
PNG
(US9695132, I-181)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4CNC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H24Cl2N6O4/c1-5-19(34)28-11-14-8-6-7-9-16(14)30-24-29-12-15-13-33(25(35)32(2)23(15)31-24)22-20(26)17(36-3)10-18(37-4)21(22)27/h5-10,12H,1,11,13H2,2-4H3,(H,28,34)(H,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100309
PNG
(US9695132, I-202)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(CC4NC(=O)C=C)c4ccccn4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C27H28Cl2N8O4/c1-5-21(38)32-16-13-36(20-8-6-7-9-30-20)14-17(16)33-26-31-11-15-12-37(27(39)35(2)25(15)34-26)24-22(28)18(40-3)10-19(41-4)23(24)29/h5-11,16-17H,1,12-14H2,2-4H3,(H,32,38)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100888
PNG
(US9695132, I-232)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)C(Cc3cnc(Nc4cccc(NC(=O)C=C)c4)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C34H32Cl2N6O5/c1-5-27(43)38-21-10-7-9-19(13-21)18-42-32-20(14-24(33(42)45)29-30(35)25(46-3)16-26(47-4)31(29)36)17-37-34(41-32)40-23-12-8-11-22(15-23)39-28(44)6-2/h6-13,15-17,24H,2,5,14,18H2,1,3-4H3,(H,38,43)(H,39,44)(H,37,40,41)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101066
PNG
(US9695132, I-244)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H21Cl2N5O4/c1-5-19(33)29-15-8-6-7-9-16(15)30-25-28-12-13-10-14(24(34)32(2)23(13)31-25)20-21(26)17(35-3)11-18(36-4)22(20)27/h5-12H,1H2,2-4H3,(H,29,33)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88652
PNG
(US9695132, I-15)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H36N8O4/c1-6-27(39)32-26-16-21(37-12-10-36(7-2)11-13-37)8-9-25(26)33-29-31-18-20-19-38(30(40)35(3)28(20)34-29)22-14-23(41-4)17-24(15-22)42-5/h6,8-9,14-18H,1,7,10-13,19H2,2-5H3,(H,32,39)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88658
PNG
(US9695132, I-21)
Show SMILES COCCN(C)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C28H33N7O5/c1-7-25(36)30-24-14-19(33(2)10-11-38-4)8-9-23(24)31-27-29-16-18-17-35(28(37)34(3)26(18)32-27)20-12-21(39-5)15-22(13-20)40-6/h7-9,12-16H,1,10-11,17H2,2-6H3,(H,30,36)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88672
PNG
(US9695132, I-35)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3cccnc3)C2=O)c1Cl
Show InChI InChI=1S/C29H31Cl2N7O4/c1-4-23(39)34-19-9-5-6-10-20(19)35-28-33-14-18-16-37(26-24(30)21(41-2)12-22(42-3)25(26)31)29(40)38(27(18)36-28)15-17-8-7-11-32-13-17/h4,7-8,11-14,19-20H,1,5-6,9-10,15-16H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88684
PNG
(US9695132, I-42)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)C(F)(F)F)nc2N(C)C1=O
Show InChI InChI=1S/C25H23F3N6O4/c1-5-21(35)30-20-8-15(25(26,27)28)6-7-19(20)31-23-29-12-14-13-34(24(36)33(2)22(14)32-23)16-9-17(37-3)11-18(10-16)38-4/h5-12H,1,13H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89503
PNG
(US9695132, I-48)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC#N)C1=O
Show InChI InChI=1S/C25H23N7O4/c1-4-22(33)28-20-7-5-6-8-21(20)29-24-27-14-16-15-32(25(34)31(10-9-26)23(16)30-24)17-11-18(35-2)13-19(12-17)36-3/h4-8,11-14H,1,10,15H2,2-3H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91653
PNG
(US9695132, I-59)
Show SMILES COCCN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H28N6O5/c1-5-23(33)28-21-8-6-7-9-22(21)29-25-27-15-17-16-32(18-12-19(36-3)14-20(13-18)37-4)26(34)31(10-11-35-2)24(17)30-25/h5-9,12-15H,1,10-11,16H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91682
PNG
(US9695132, I-62)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)N4CCC(CC4)C(=O)OC(C)(C)C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C34H39Cl2N7O6/c1-8-26(44)38-23-15-21(42-13-11-19(12-14-42)31(45)49-34(2,3)4)9-10-22(23)39-32-37-17-20-18-43(33(46)41(5)30(20)40-32)29-27(35)24(47-6)16-25(48-7)28(29)36/h8-10,15-17,19H,1,11-14,18H2,2-7H3,(H,38,44)(H,37,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91858
PNG
(US9695132, I-63)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H32Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-7,10-11,14-15,20-21H,1,8-9,12-13,16-17H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101124
PNG
(US9695132, I-104)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC(F)F)C1=O
Show InChI InChI=1S/C25H23ClF2N6O4/c1-4-21(35)30-16-7-5-6-8-17(16)31-24-29-11-14-12-33(25(36)34(13-20(27)28)23(14)32-24)18-9-15(37-2)10-19(38-3)22(18)26/h4-11,20H,1,12-13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92612
PNG
(US9695132, I-114 | US9695132, I-86)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3cscn3)C2=O)c1Cl
Show InChI InChI=1S/C27H23Cl2N7O4S/c1-4-21(37)32-17-7-5-6-8-18(17)33-26-30-10-15-11-35(24-22(28)19(39-2)9-20(40-3)23(24)29)27(38)36(25(15)34-26)12-16-13-41-14-31-16/h4-10,13-14H,1,11-12H2,2-3H3,(H,32,37)(H,30,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94676
PNG
(US9695132, I-123)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)N4CCN(CC4)C(=O)CCC(O)=O)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C32H34Cl2N8O7/c1-5-24(43)36-21-14-19(40-10-12-41(13-11-40)25(44)8-9-26(45)46)6-7-20(21)37-31-35-16-18-17-42(32(47)39(2)30(18)38-31)29-27(33)22(48-3)15-23(49-4)28(29)34/h5-7,14-16H,1,8-13,17H2,2-4H3,(H,36,43)(H,45,46)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101160
PNG
(US9695132, I-131)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1F
Show InChI InChI=1S/C24H22F2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99850
PNG
(US9695132, I-196)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CC(=O)NCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H25Cl2N7O5/c1-5-16(33)28-13-9-26-17(34)6-12(13)29-22-27-8-11-10-32(23(35)31(2)21(11)30-22)20-18(24)14(36-3)7-15(37-4)19(20)25/h5,7-8,12-13H,1,6,9-10H2,2-4H3,(H,26,34)(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100408
PNG
(US9695132, I-213)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(Cc3cnn(C)c3)C2=O)c1Cl
Show InChI InChI=1S/C26H28Cl2N8O5/c1-5-20(37)31-16-12-41-13-17(16)32-25-29-8-15-11-35(23-21(27)18(39-3)6-19(40-4)22(23)28)26(38)36(24(15)33-25)10-14-7-30-34(2)9-14/h5-9,16-17H,1,10-13H2,2-4H3,(H,31,37)(H,29,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88651
PNG
(US9695132, I-14)
Show SMILES COCCOc1ccc(Nc2ncc3CN(C(=O)N(Cc4ccccc4)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C33H34N6O6/c1-5-30(40)35-29-18-25(45-14-13-42-2)11-12-28(29)36-32-34-19-23-21-38(24-15-26(43-3)17-27(16-24)44-4)33(41)39(31(23)37-32)20-22-9-7-6-8-10-22/h5-12,15-19H,1,13-14,20-21H2,2-4H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88654
PNG
(US9695132, I-17)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)nc2N(C)C1=O
Show InChI InChI=1S/C28H31N7O5/c1-5-25(36)30-24-14-19(34-8-10-40-11-9-34)6-7-23(24)31-27-29-16-18-17-35(28(37)33(2)26(18)32-27)20-12-21(38-3)15-22(13-20)39-4/h5-7,12-16H,1,8-11,17H2,2-4H3,(H,30,36)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88660
PNG
(US9695132, I-23)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C3CC3)C2=O)c1Cl
Show InChI InChI=1S/C26H24Cl2N6O4/c1-4-20(35)30-16-7-5-6-8-17(16)31-25-29-12-14-13-33(26(36)34(15-9-10-15)24(14)32-25)23-21(27)18(37-2)11-19(38-3)22(23)28/h4-8,11-12,15H,1,9-10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88681
PNG
(US9695132, I-40)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CCNCC2)C1=O
Show InChI InChI=1S/C29H33N7O4/c1-4-26(37)32-24-7-5-6-8-25(24)33-28-31-16-20-18-35(21-13-22(39-2)15-23(14-21)40-3)29(38)36(27(20)34-28)17-19-9-11-30-12-10-19/h4-8,13-16,19,30H,1,9-12,17-18H2,2-3H3,(H,32,37)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91681
PNG
(US9695132, I-61)
Show SMILES COCCN1C(=O)N(Cc2cnc(NC3CCCCC3NC(=O)C=C)nc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H32Cl2N6O5/c1-5-20(35)30-16-8-6-7-9-17(16)31-25-29-13-15-14-34(26(36)33(10-11-37-2)24(15)32-25)23-21(27)18(38-3)12-19(39-4)22(23)28/h5,12-13,16-17H,1,6-11,14H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88560
PNG
(US9695132, I-2 | US9695132, I-65)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92611
PNG
(US9695132, I-85)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C3CCNCC3)C2=O)c1Cl
Show InChI InChI=1S/C28H29Cl2N7O4/c1-4-22(38)33-18-7-5-6-8-19(18)34-27-32-14-16-15-36(25-23(29)20(40-2)13-21(41-3)24(25)30)28(39)37(26(16)35-27)17-9-11-31-12-10-17/h4-8,13-14,17,31H,1,9-12,15H2,2-3H3,(H,33,38)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92748
PNG
(US9695132, I-92)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3nccs3)C2=O)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O4S/c1-4-20(37)32-16-7-5-6-8-17(16)33-26-31-12-15-13-35(24-22(28)18(39-2)11-19(40-3)23(24)29)27(38)36(25(15)34-26)14-21-30-9-10-41-21/h4,9-12,16-17H,1,5-8,13-14H2,2-3H3,(H,32,37)(H,31,33,34)/t16-,17+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101135
PNG
(US9695132, I-110)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCF)C1=O
Show InChI InChI=1S/C25H24ClFN6O4/c1-4-21(34)29-17-7-5-6-8-18(17)30-24-28-13-15-14-33(25(35)32(10-9-27)23(15)31-24)19-11-16(36-2)12-20(37-3)22(19)26/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101145
PNG
(US9695132, I-129)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC3CC3)C2=O)c1Cl
Show InChI InChI=1S/C27H32Cl2N6O4/c1-4-21(36)31-17-7-5-6-8-18(17)32-26-30-12-16-14-34(27(37)35(25(16)33-26)13-15-9-10-15)24-22(28)19(38-2)11-20(39-3)23(24)29/h4,11-12,15,17-18H,1,5-10,13-14H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94698
PNG
(US9695132, I-139)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(CC4NC(=O)C=C)C(C)=O)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H27Cl2N7O5/c1-6-18(35)28-14-10-32(12(2)34)11-15(14)29-23-27-8-13-9-33(24(36)31(3)22(13)30-23)21-19(25)16(37-4)7-17(38-5)20(21)26/h6-8,14-15H,1,9-11H2,2-5H3,(H,28,35)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM97560
PNG
(US9695132, I-146)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)-c3nnn(C)n3)nc2N(C)C1=O
Show InChI InChI=1S/C26H26N10O4/c1-6-22(37)28-21-9-15(23-31-33-35(3)32-23)7-8-20(21)29-25-27-13-16-14-36(26(38)34(2)24(16)30-25)17-10-18(39-4)12-19(11-17)40-5/h6-13H,1,14H2,2-5H3,(H,28,37)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99788
PNG
(US9695132, I-186)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4COC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C22H24Cl2N6O5/c1-5-16(31)26-12-9-35-10-13(12)27-21-25-7-11-8-30(22(32)29(2)20(11)28-21)19-17(23)14(33-3)6-15(34-4)18(19)24/h5-7,12-13H,1,8-10H2,2-4H3,(H,26,31)(H,25,27,28)/t12-,13+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99855
PNG
(US9695132, I-198)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N6O5/c1-5-16(31)26-12-9-35-10-13(12)27-21-25-7-11-8-30(22(32)29(2)20(11)28-21)19-17(23)14(33-3)6-15(34-4)18(19)24/h5-7,12-13H,1,8-10H2,2-4H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100366
PNG
(US9695132, I-210)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(Cc3cscn3)C2=O)c1Cl
Show InChI InChI=1S/C25H25Cl2N7O5S/c1-4-19(35)30-15-9-39-10-16(15)31-24-28-6-13-7-33(22-20(26)17(37-2)5-18(38-3)21(22)27)25(36)34(23(13)32-24)8-14-11-40-12-29-14/h4-6,11-12,15-16H,1,7-10H2,2-3H3,(H,30,35)(H,28,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100422
PNG
(US9695132, I-216)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(Cc3cc[nH]n3)C2=O)c1Cl
Show InChI InChI=1S/C25H26Cl2N8O5/c1-4-19(36)30-15-11-40-12-16(15)31-24-28-8-13-9-34(22-20(26)17(38-2)7-18(39-3)21(22)27)25(37)35(23(13)32-24)10-14-5-6-29-33-14/h4-8,15-16H,1,9-12H2,2-3H3,(H,29,33)(H,30,36)(H,28,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100952
PNG
(US9695132, I-233)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)C(Cc3cnc(Nc4ccc(NC(=O)C=C)cc4)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C34H32Cl2N6O5/c1-5-27(43)38-21-10-12-22(13-11-21)40-34-37-17-20-15-24(29-30(35)25(46-3)16-26(47-4)31(29)36)33(45)42(32(20)41-34)18-19-8-7-9-23(14-19)39-28(44)6-2/h5,7-14,16-17,24H,1,6,15,18H2,2-4H3,(H,38,43)(H,39,44)(H,37,40,41)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88567
PNG
(US9695132, I-9)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccc(cc4NC(=O)C=C)N4CCN(CCOC)CC4)nc23)c2cc(OC)cc(OC)c2)c1
Show InChI InChI=1S/C40H47N9O6/c1-6-36(50)42-29-10-8-9-27(19-29)25-49-38-28(26-48(40(49)52)31-20-32(54-4)23-33(21-31)55-5)24-41-39(45-38)44-34-12-11-30(22-35(34)43-37(51)7-2)47-15-13-46(14-16-47)17-18-53-3/h7-12,19-24H,2,6,13-18,25-26H2,1,3-5H3,(H,42,50)(H,43,51)(H,41,44,45)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88665
PNG
(US9695132, I-28)
Show SMILES COc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C31H28Cl2N6O5/c1-5-25(40)35-21-11-6-7-12-22(21)36-30-34-15-19-17-38(28-26(32)23(43-3)14-24(44-4)27(28)33)31(41)39(29(19)37-30)16-18-9-8-10-20(13-18)42-2/h5-15H,1,16-17H2,2-4H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88667
PNG
(US9695132, I-30)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c1
Show InChI InChI=1S/C30H36N8O4/c1-6-27(39)32-25-9-8-21(37-12-10-36(7-2)11-13-37)16-26(25)33-29-31-18-20-19-38(30(40)35(3)28(20)34-29)22-14-23(41-4)17-24(15-22)42-5/h6,8-9,14-18H,1,7,10-13,19H2,2-5H3,(H,32,39)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88669
PNG
(US9695132, I-32)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC=C)C1=O
Show InChI InChI=1S/C26H26N6O4/c1-5-11-31-24-17(16-32(26(31)34)18-12-19(35-3)14-20(13-18)36-4)15-27-25(30-24)29-22-10-8-7-9-21(22)28-23(33)6-2/h5-10,12-15H,1-2,11,16H2,3-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92533
PNG
(US9695132, I-78)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(ccc3NC(=O)C=C)-c3nccs3)nc2N(C)C1=O
Show InChI InChI=1S/C27H25N7O4S/c1-5-23(35)30-21-7-6-16(25-28-8-9-39-25)10-22(21)31-26-29-14-17-15-34(27(36)33(2)24(17)32-26)18-11-19(37-3)13-20(12-18)38-4/h5-14H,1,15H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92734
PNG
(US9695132, I-87)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2ccnc(N)c2)C1=O
Show InChI InChI=1S/C29H28N8O4/c1-4-26(38)33-23-7-5-6-8-24(23)34-28-32-15-19-17-36(20-12-21(40-2)14-22(13-20)41-3)29(39)37(27(19)35-28)16-18-9-10-31-25(30)11-18/h4-15H,1,16-17H2,2-3H3,(H2,30,31)(H,33,38)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101111
PNG
(US9695132, I-100)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CC2)C1=O
Show InChI InChI=1S/C27H27ClN6O4/c1-4-23(35)30-19-7-5-6-8-20(19)31-26-29-13-17-15-33(21-11-18(37-2)12-22(38-3)24(21)28)27(36)34(25(17)32-26)14-16-9-10-16/h4-8,11-13,16H,1,9-10,14-15H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101123
PNG
(US9695132, I-103)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(CC(F)F)C2=O)c1Cl
Show InChI InChI=1S/C25H22Cl2F2N6O4/c1-4-19(36)31-14-7-5-6-8-15(14)32-24-30-10-13-11-34(25(37)35(12-18(28)29)23(13)33-24)22-20(26)16(38-2)9-17(39-3)21(22)27/h4-10,18H,1,11-12H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101133
PNG
(US9695132, I-108)
Show SMILES COc1cc(OC)c(F)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H23FN6O4/c1-5-20(32)27-16-8-6-7-9-17(16)28-23-26-12-14-13-31(24(33)30(2)22(14)29-23)18-10-15(34-3)11-19(35-4)21(18)25/h5-12H,1,13H2,2-4H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94662
PNG
(US9695132, I-112)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O4/c1-5-17(32)27-13-7-6-8-14(13)28-22-26-10-12-11-31(23(33)30(2)21(12)29-22)20-18(24)15(34-3)9-16(35-4)19(20)25/h5,9-10,13-14H,1,6-8,11H2,2-4H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101174
PNG
(US9695132, I-132)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3ccn(C)c(=O)c3)C2=O)c1Cl
Show InChI InChI=1S/C30H33Cl2N7O5/c1-5-23(40)34-19-8-6-7-9-20(19)35-29-33-14-18-16-38(27-25(31)21(43-3)13-22(44-4)26(27)32)30(42)39(28(18)36-29)15-17-10-11-37(2)24(41)12-17/h5,10-14,19-20H,1,6-9,15-16H2,2-4H3,(H,34,40)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94692
PNG
(US9695132, I-137)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3csc(C)n3)C2=O)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4S/c1-5-22(38)33-18-8-6-7-9-19(18)34-27-31-11-16-12-36(25-23(29)20(40-3)10-21(41-4)24(25)30)28(39)37(26(16)35-27)13-17-14-42-15(2)32-17/h5,10-11,14,18-19H,1,6-9,12-13H2,2-4H3,(H,33,38)(H,31,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM97580
PNG
(US9695132, I-147)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3ccn(C)n3)C2=O)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-5-22(39)32-18-8-6-7-9-19(18)33-27-31-13-16-14-37(25-23(29)20(41-3)12-21(42-4)24(25)30)28(40)38(26(16)34-27)15-17-10-11-36(2)35-17/h5,10-13,18-19H,1,6-9,14-15H2,2-4H3,(H,32,39)(H,31,33,34)/t18-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100954
PNG
(US9695132, I-241)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C23H23Cl2N5O5/c1-5-17(31)27-13-9-35-10-14(13)28-23-26-8-11-6-12(22(32)30(2)21(11)29-23)18-19(24)15(33-3)7-16(34-4)20(18)25/h5-8,13-14H,1,9-10H2,2-4H3,(H,27,31)(H,26,28,29)/t13-,14+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101088
PNG
(US9695132, I-245)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccc(F)cc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H20Cl2FN5O4/c1-5-19(34)30-16-9-13(28)6-7-15(16)31-25-29-11-12-8-14(24(35)33(2)23(12)32-25)20-21(26)17(36-3)10-18(37-4)22(20)27/h5-11H,1H2,2-4H3,(H,30,34)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88650
PNG
(US9695132, I-13)
Show SMILES COCCN(C)c1ccc(Nc2ncc3CN(C(=O)N(Cc4ccccc4)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C34H37N7O5/c1-6-31(42)36-30-18-25(39(2)14-15-44-3)12-13-29(30)37-33-35-20-24-22-40(26-16-27(45-4)19-28(17-26)46-5)34(43)41(32(24)38-33)21-23-10-8-7-9-11-23/h6-13,16-20H,1,14-15,21-22H2,2-5H3,(H,36,42)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92535
PNG
(US9695132, I-80)
Show SMILES CCN1CCC(CC1)N1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C30H35N7O4/c1-5-27(38)32-25-9-7-8-10-26(25)33-29-31-18-20-19-36(22-15-23(40-3)17-24(16-22)41-4)30(39)37(28(20)34-29)21-11-13-35(6-2)14-12-21/h5,7-10,15-18,21H,1,6,11-14,19H2,2-4H3,(H,32,38)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101125
PNG
(US9695132, I-105)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC(F)F)C2=O)c1Cl
Show InChI InChI=1S/C25H28Cl2F2N6O4/c1-4-19(36)31-14-7-5-6-8-15(14)32-24-30-10-13-11-34(25(37)35(12-18(28)29)23(13)33-24)22-20(26)16(38-2)9-17(39-3)21(22)27/h4,9-10,14-15,18H,1,5-8,11-12H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92534
PNG
(US9695132, I-79)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCN(C)CC2)C1=O
Show InChI InChI=1S/C29H33N7O4/c1-5-26(37)31-24-8-6-7-9-25(24)32-28-30-17-19-18-35(21-14-22(39-3)16-23(15-21)40-4)29(38)36(27(19)33-28)20-10-12-34(2)13-11-20/h5-9,14-17,20H,1,10-13,18H2,2-4H3,(H,31,37)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88666
PNG
(US9695132, I-29)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4N(C)C(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H24Cl2N6O4/c1-6-19(34)31(2)16-10-8-7-9-15(16)29-24-28-12-14-13-33(25(35)32(3)23(14)30-24)22-20(26)17(36-4)11-18(37-5)21(22)27/h6-12H,1,13H2,2-5H3,(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101090
PNG
(US9695132, I-246)
Show SMILES CN1C(=O)N(Cc2cnc(NC3COCC3NC(=O)C=C)nc12)c1cc(ccc1Cl)C(=O)Nc1cccc(c1)C(C)(C)C#N
Show InChI InChI=1S/C31H31ClN8O4/c1-5-26(41)36-23-15-44-16-24(23)37-29-34-13-19-14-40(30(43)39(4)27(19)38-29)25-11-18(9-10-22(25)32)28(42)35-21-8-6-7-20(12-21)31(2,3)17-33/h5-13,23-24H,1,14-16H2,2-4H3,(H,35,42)(H,36,41)(H,34,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101222
PNG
(US9695132, I-236)
Show SMILES CCC(=O)Nc1ccccc1Nc1ncc2CN(C(=O)N(Cc3ccccc3)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C30H28Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h5-15H,4,16-17H2,1-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101210
PNG
(US9695132, I-235)
Show SMILES CCC(=O)Nc1ccccc1Nc1ncc2CN(C(=O)N(C)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h6-11H,5,12H2,1-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94685
PNG
(US9695132, I-128)
Show SMILES COc1cc(OC)cc(c1)-c1nc2cnc(Nc3ccccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C24H22N6O4/c1-5-20(31)26-17-8-6-7-9-18(17)28-24-25-13-19-22(29-24)30(2)23(32)21(27-19)14-10-15(33-3)12-16(11-14)34-4/h5-13H,1H2,2-4H3,(H,26,31)(H,25,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101140
PNG
(US9695132, I-115)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C25H28F4N6O4/c1-4-19(36)31-14-7-5-6-8-15(14)32-24-30-10-13-11-34(25(37)35(12-18(26)27)23(13)33-24)22-20(28)16(38-2)9-17(39-3)21(22)29/h4,9-10,14-15,18H,1,5-8,11-12H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91870
PNG
(US9695132, I-68)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(C3CC3)C2=O)c1Cl
Show InChI InChI=1S/C26H30Cl2N6O4/c1-4-20(35)30-16-7-5-6-8-17(16)31-25-29-12-14-13-33(26(36)34(15-9-10-15)24(14)32-25)23-21(27)18(37-2)11-19(38-3)22(23)28/h4,11-12,15-17H,1,5-10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88656
PNG
(US9695132, I-19 | US9695132, I-22)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H28Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88649
PNG
(US9695132, I-12)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3cccc(F)c3)C2=O)c1Cl
Show InChI InChI=1S/C30H25Cl2FN6O4/c1-4-24(40)35-20-10-5-6-11-21(20)36-29-34-14-18-16-38(27-25(31)22(42-2)13-23(43-3)26(27)32)30(41)39(28(18)37-29)15-17-8-7-9-19(33)12-17/h4-14H,1,15-16H2,2-3H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94675
PNG
(US9695132, I-122)
Show SMILES CCN1CCN(Cc2ccc(Nc3ncc4CN(C(=O)N(C)c4n3)c3cc(OC)cc(OC)c3)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C31H38N8O4/c1-6-28(40)33-27-14-21(19-38-12-10-37(7-2)11-13-38)8-9-26(27)34-30-32-18-22-20-39(31(41)36(3)29(22)35-30)23-15-24(42-4)17-25(16-23)43-5/h6,8-9,14-18H,1,7,10-13,19-20H2,2-5H3,(H,33,40)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101128
PNG
(US9695132, I-106 | US9695132, I-111)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CCF)C2=O)c1Cl
Show InChI InChI=1S/C25H29Cl2FN6O4/c1-4-19(35)30-15-7-5-6-8-16(15)31-24-29-12-14-13-34(25(36)33(10-9-28)23(14)32-24)22-20(26)17(37-2)11-18(38-3)21(22)27/h4,11-12,15-16H,1,5-10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92609
PNG
(US9695132, I-83)
Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H18Cl2N6O2/c1-3-18(31)26-16-9-4-5-10-17(16)27-21-25-11-13-12-30(22(32)29(2)20(13)28-21)19-14(23)7-6-8-15(19)24/h3-11H,1,12H2,2H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92536
PNG
(US9695132, I-81)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCNCC2)C1=O
Show InChI InChI=1S/C28H31N7O4/c1-4-25(36)31-23-7-5-6-8-24(23)32-27-30-16-18-17-34(20-13-21(38-2)15-22(14-20)39-3)28(37)35(26(18)33-27)19-9-11-29-12-10-19/h4-8,13-16,19,29H,1,9-12,17H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91874
PNG
(US9695132, I-73)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3NC2=O)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O4/c1-4-17(32)27-13-7-5-6-8-14(13)28-22-26-10-12-11-31(23(33)30-21(12)29-22)20-18(24)15(34-2)9-16(35-3)19(20)25/h4,9-10,13-14H,1,5-8,11H2,2-3H3,(H,27,32)(H2,26,28,29,30,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101091
PNG
(US9695132, I-247)
Show SMILES CN1C(=O)N(Cc2cnc(NC3COCC3NC(=O)C=C)nc12)c1cc(ccc1Cl)C(=O)Nc1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C31H34ClN7O4/c1-6-26(40)35-23-16-43-17-24(23)36-29-33-14-19-15-39(30(42)38(5)27(19)37-29)25-12-18(10-11-22(25)32)28(41)34-21-9-7-8-20(13-21)31(2,3)4/h6-14,23-24H,1,15-17H2,2-5H3,(H,34,41)(H,35,40)(H,33,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101203
PNG
(US9695132, I-234)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)CC)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C33H33Cl2N7O5/c1-5-26(43)37-21-11-9-10-19(14-21)17-42-31-20(16-36-32(40-31)39-23-13-8-7-12-22(23)38-27(44)6-2)18-41(33(42)45)30-28(34)24(46-3)15-25(47-4)29(30)35/h7-16H,5-6,17-18H2,1-4H3,(H,37,43)(H,38,44)(H,36,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94695
PNG
(US9695132, I-138)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(C)CC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H27Cl2N7O4/c1-6-17(33)27-13-10-30(2)11-14(13)28-22-26-8-12-9-32(23(34)31(3)21(12)29-22)20-18(24)15(35-4)7-16(36-5)19(20)25/h6-8,13-14H,1,9-11H2,2-5H3,(H,27,33)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88662
PNG
(US9695132, I-25)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccc(F)cc3)C2=O)c1Cl
Show InChI InChI=1S/C30H25Cl2FN6O4/c1-4-24(40)35-20-7-5-6-8-21(20)36-29-34-14-18-16-38(27-25(31)22(42-2)13-23(43-3)26(27)32)30(41)39(28(18)37-29)15-17-9-11-19(33)12-10-17/h4-14H,1,15-16H2,2-3H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100461
PNG
(US9695132, I-219)
Show SMILES CCOc1cc(OCC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C26H32Cl2N6O4/c1-5-20(35)30-16-10-8-9-11-17(16)31-25-29-13-15-14-34(26(36)33(4)24(15)32-25)23-21(27)18(37-6-2)12-19(22(23)28)38-7-3/h5,12-13,16-17H,1,6-11,14H2,2-4H3,(H,30,35)(H,29,31,32)/t16-,17+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98641
PNG
(US9695132, I-154)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(CC4NC(=O)C=C)C4CCN(C)CC4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C28H36Cl2N8O4/c1-6-22(39)32-18-14-37(17-7-9-35(2)10-8-17)15-19(18)33-27-31-12-16-13-38(28(40)36(3)26(16)34-27)25-23(29)20(41-4)11-21(42-5)24(25)30/h6,11-12,17-19H,1,7-10,13-15H2,2-5H3,(H,32,39)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94680
PNG
(US9695132, I-125)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2NC1=O
Show InChI InChI=1S/C23H22N6O4/c1-4-20(30)25-18-7-5-6-8-19(18)26-22-24-12-14-13-29(23(31)28-21(14)27-22)15-9-16(32-2)11-17(10-15)33-3/h4-12H,1,13H2,2-3H3,(H,25,30)(H2,24,26,27,28,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88674
PNG
(US9695132, I-37)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4N(C)C(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C31H28Cl2N6O4/c1-5-25(40)37(2)22-14-10-9-13-21(22)35-30-34-16-20-18-38(28-26(32)23(42-3)15-24(43-4)27(28)33)31(41)39(29(20)36-30)17-19-11-7-6-8-12-19/h5-16H,1,17-18H2,2-4H3,(H,34,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100841
PNG
(US9695132, I-228)
Show SMILES COc1cc(OC)c(Br)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1F
Show InChI InChI=1S/C24H28BrFN6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)/t14-,15+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101223
PNG
(US9695132, I-237)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3)nc2N(C)C1=O
Show InChI InChI=1S/C21H21N5O3/c1-25-19-14(12-22-20(24-19)23-15-7-5-4-6-8-15)13-26(21(25)27)16-9-17(28-2)11-18(10-16)29-3/h4-12H,13H2,1-3H3,(H,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100313
PNG
(US9695132, I-205)
Show SMILES CCOc1cc(OCC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H28Cl2N6O5/c1-5-18(33)28-14-11-35-12-15(14)29-23-27-9-13-10-32(24(34)31(4)22(13)30-23)21-19(25)16(36-6-2)8-17(20(21)26)37-7-3/h5,8-9,14-15H,1,6-7,10-12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94699
PNG
(US9695132, I-140)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCOC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O5/c1-5-17(32)27-14-11-36-7-6-13(14)28-22-26-9-12-10-31(23(33)30(2)21(12)29-22)20-18(24)15(34-3)8-16(35-4)19(20)25/h5,8-9,13-14H,1,6-7,10-11H2,2-4H3,(H,27,32)(H,26,28,29)/t13-,14+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101114
PNG
(US9695132, I-101)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(NC3CCCCC3NC(=O)C=C)nc2N(CC2CC2)C1=O
Show InChI InChI=1S/C27H33ClN6O4/c1-4-23(35)30-19-7-5-6-8-20(19)31-26-29-13-17-15-33(21-11-18(37-2)12-22(38-3)24(21)28)27(36)34(25(17)32-26)14-16-9-10-16/h4,11-13,16,19-20H,1,5-10,14-15H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100364
PNG
(US9695132, I-208)
Show SMILES COc1c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(C)C2=O)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C23H26Cl2N6O6/c1-6-14(32)27-12-9-37-10-13(12)28-22-26-7-11-8-31(23(33)30(2)21(11)29-22)17-15(24)18(34-3)20(36-5)19(35-4)16(17)25/h6-7,12-13H,1,8-10H2,2-5H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91646
PNG
(US9695132, I-52)
Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)C1CCCCC1
Show InChI InChI=1S/C22H26N6O2/c1-3-19(29)24-17-11-7-8-12-18(17)25-21-23-13-15-14-28(16-9-5-4-6-10-16)22(30)27(2)20(15)26-21/h3,7-8,11-13,16H,1,4-6,9-10,14H2,2H3,(H,24,29)(H,23,25,26)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88565
PNG
(US9695132, I-7)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(NC4CCCCC4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C33H37Cl2N7O5/c1-5-26(43)37-21-11-9-10-19(14-21)17-42-31-20(16-36-32(40-31)39-23-13-8-7-12-22(23)38-27(44)6-2)18-41(33(42)45)30-28(34)24(46-3)15-25(47-4)29(30)35/h6,9-11,14-16,22-23H,2,5,7-8,12-13,17-18H2,1,3-4H3,(H,37,43)(H,38,44)(H,36,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92610
PNG
(US9695132, I-84)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)-c3nccs3)nc2N(C)C1=O
Show InChI InChI=1S/C27H25N7O4S/c1-5-23(35)30-22-10-16(25-28-8-9-39-25)6-7-21(22)31-26-29-14-17-15-34(27(36)33(2)24(17)32-26)18-11-19(37-3)13-20(12-18)38-4/h5-14H,1,15H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88656
PNG
(US9695132, I-19 | US9695132, I-22)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H28Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88676
PNG
(US9695132, I-38)
Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1ccccc1
Show InChI InChI=1S/C22H20N6O2/c1-3-19(29)24-17-11-7-8-12-18(17)25-21-23-13-15-14-28(16-9-5-4-6-10-16)22(30)27(2)20(15)26-21/h3-13H,1,14H2,2H3,(H,24,29)(H,23,25,26)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101128
PNG
(US9695132, I-106 | US9695132, I-111)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CCF)C2=O)c1Cl
Show InChI InChI=1S/C25H29Cl2FN6O4/c1-4-19(35)30-15-7-5-6-8-16(15)31-24-29-12-14-13-34(25(36)33(10-9-28)23(14)32-24)22-20(26)17(37-2)11-18(38-3)21(22)27/h4,11-12,15-16H,1,5-10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88648
PNG
(US9695132, I-11)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cc(Cl)c(Cl)cc4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H24Cl4N6O4/c1-4-24(41)36-20-10-18(31)19(32)11-21(20)37-29-35-13-17-15-39(27-25(33)22(43-2)12-23(44-3)26(27)34)30(42)40(28(17)38-29)14-16-8-6-5-7-9-16/h4-13H,1,14-15H2,2-3H3,(H,36,41)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88564
PNG
(US9695132, I-6)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)C(F)(F)F)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C31H25Cl2F3N6O4/c1-4-24(43)38-21-12-19(31(34,35)36)10-11-20(21)39-29-37-14-18-16-41(27-25(32)22(45-2)13-23(46-3)26(27)33)30(44)42(28(18)40-29)15-17-8-6-5-7-9-17/h4-14H,1,15-16H2,2-3H3,(H,38,43)(H,37,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92413
PNG
(US9695132, I-76)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(NC3CCCCC3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H29ClN6O4/c1-5-20(32)27-16-8-6-7-9-17(16)28-23-26-12-14-13-31(24(33)30(2)22(14)29-23)18-10-15(34-3)11-19(35-4)21(18)25/h5,10-12,16-17H,1,6-9,13H2,2-4H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100462
PNG
(US9695132, I-220)
Show SMILES COc1cc(cc(OC)c1OC)N1Cc2cnc(N[C@@H]3CCCC[C@@H]3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H32N6O5/c1-6-21(32)27-17-9-7-8-10-18(17)28-24-26-13-15-14-31(25(33)30(2)23(15)29-24)16-11-19(34-3)22(36-5)20(12-16)35-4/h6,11-13,17-18H,1,7-10,14H2,2-5H3,(H,27,32)(H,26,28,29)/t17-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101200
PNG
(US9695132, I-118)
Show SMILES CCC(=O)N[C@H]1CCCC[C@H]1Nc1ncc2CN(C(=O)N(Cc3cscn3)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4S/c1-4-21(37)32-17-7-5-6-8-18(17)33-26-30-10-15-11-35(24-22(28)19(39-2)9-20(40-3)23(24)29)27(38)36(25(15)34-26)12-16-13-41-14-31-16/h9-10,13-14,17-18H,4-8,11-12H2,1-3H3,(H,32,37)(H,30,33,34)/t17-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92777
PNG
(US9695132, I-93)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@H]4CCCC[C@H]4NC(=O)C=C)nc3N(Cc3nccs3)C2=O)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O4S/c1-4-20(37)32-16-7-5-6-8-17(16)33-26-31-12-15-13-35(24-22(28)18(39-2)11-19(40-3)23(24)29)27(38)36(25(15)34-26)14-21-30-9-10-41-21/h4,9-12,16-17H,1,5-8,13-14H2,2-3H3,(H,32,37)(H,31,33,34)/t16-,17+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88677
PNG
(US9695132, I-39)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(NC3CCCCC3N(C)C(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H32N6O4/c1-6-22(32)29(2)21-10-8-7-9-20(21)27-24-26-14-16-15-31(25(33)30(3)23(16)28-24)17-11-18(34-4)13-19(12-17)35-5/h6,11-14,20-21H,1,7-10,15H2,2-5H3,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100432
PNG
(US9695132, I-218)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4N(C)C(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O5/c1-6-17(32)29(2)14-11-36-10-13(14)27-22-26-8-12-9-31(23(33)30(3)21(12)28-22)20-18(24)15(34-4)7-16(35-5)19(20)25/h6-8,13-14H,1,9-11H2,2-5H3,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88655
PNG
(US9695132, I-18)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(NC3CCCCC3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H30N6O4/c1-5-21(31)26-19-8-6-7-9-20(19)27-23-25-13-15-14-30(24(32)29(2)22(15)28-23)16-10-17(33-3)12-18(11-16)34-4/h5,10-13,19-20H,1,6-9,14H2,2-4H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100362
PNG
(US9695132, I-207)
Show SMILES COc1cc(cc(OC)c1OC)N1Cc2cnc(NC3COCC3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C23H28N6O6/c1-6-19(30)25-15-11-35-12-16(15)26-22-24-9-13-10-29(23(31)28(2)21(13)27-22)14-7-17(32-3)20(34-5)18(8-14)33-4/h6-9,15-16H,1,10-12H2,2-5H3,(H,25,30)(H,24,26,27)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101132
PNG
(US9695132, I-107)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(NC3CCCCC3NC(=O)C=C)nc2N(CC(F)F)C1=O
Show InChI InChI=1S/C25H29ClF2N6O4/c1-4-21(35)30-16-7-5-6-8-17(16)31-24-29-11-14-12-33(25(36)34(13-20(27)28)23(14)32-24)18-9-15(37-2)10-19(38-3)22(18)26/h4,9-11,16-17,20H,1,5-8,12-13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94672
PNG
(US9695132, I-120)
Show SMILES CCN1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC)C1=O
Show InChI InChI=1S/C19H22N6O2/c1-4-16(26)21-14-9-7-8-10-15(14)22-18-20-11-13-12-24(5-2)19(27)25(6-3)17(13)23-18/h4,7-11H,1,5-6,12H2,2-3H3,(H,21,26)(H,20,22,23)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88688
PNG
(US9695132, I-45)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(NC3CCCCC3NC(=O)C=C)nc2N(C2CCCN(C2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C33H45N7O6/c1-7-28(41)35-26-12-8-9-13-27(26)36-30-34-18-21-19-39(23-15-24(44-5)17-25(16-23)45-6)31(42)40(29(21)37-30)22-11-10-14-38(20-22)32(43)46-33(2,3)4/h7,15-18,22,26-27H,1,8-14,19-20H2,2-6H3,(H,35,41)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM93883
PNG
(US9695132, I-96)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C29H32N6O6/c1-7-24(36)31-22-10-8-9-11-23(22)32-27-30-15-18-16-34(19-12-20(39-5)14-21(13-19)40-6)28(38)35(26(18)33-27)17-25(37)41-29(2,3)4/h7-15H,1,16-17H2,2-6H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99787
PNG
(US9695132, I-185)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@H]4COC[C@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C22H24Cl2N6O5/c1-5-16(31)26-12-9-35-10-13(12)27-21-25-7-11-8-30(22(32)29(2)20(11)28-21)19-17(23)14(33-3)6-15(34-4)18(19)24/h5-7,12-13H,1,8-10H2,2-4H3,(H,26,31)(H,25,27,28)/t12-,13+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100466
PNG
(US9695132, I-222)
Show SMILES COc1ccc(cc1)N1Cc2cnc(N[C@@H]3CCCC[C@@H]3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C23H28N6O3/c1-4-20(30)25-18-7-5-6-8-19(18)26-22-24-13-15-14-29(23(31)28(2)21(15)27-22)16-9-11-17(32-3)12-10-16/h4,9-13,18-19H,1,5-8,14H2,2-3H3,(H,25,30)(H,24,26,27)/t18-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91597
PNG
(US9695132, I-51)
Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)C1CC1
Show InChI InChI=1S/C19H20N6O2/c1-3-16(26)21-14-6-4-5-7-15(14)22-18-20-10-12-11-25(13-8-9-13)19(27)24(2)17(12)23-18/h3-7,10,13H,1,8-9,11H2,2H3,(H,21,26)(H,20,22,23)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88689
PNG
(US9695132, I-46)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(NC3CCCCC3NC(=O)C=C)nc2N(C2CCCNC2)C1=O
Show InChI InChI=1S/C28H37N7O4/c1-4-25(36)31-23-9-5-6-10-24(23)32-27-30-15-18-17-34(20-12-21(38-2)14-22(13-20)39-3)28(37)35(26(18)33-27)19-8-7-11-29-16-19/h4,12-15,19,23-24,29H,1,5-11,16-17H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92823
PNG
(US9695132, I-94)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@H]4CCCC[C@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H28Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)/t14-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94670
PNG
(US9695132, I-119)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(N[C@H]3CCCC[C@H]3NC(=O)C=C)nc2N(Cc2cscn2)C1=O
Show InChI InChI=1S/C27H30ClN7O4S/c1-4-23(36)31-19-7-5-6-8-20(19)32-26-29-11-16-12-34(21-9-18(38-2)10-22(39-3)24(21)28)27(37)35(25(16)33-26)13-17-14-40-15-30-17/h4,9-11,14-15,19-20H,1,5-8,12-13H2,2-3H3,(H,31,36)(H,29,32,33)/t19-,20+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100465
PNG
(US9695132, I-221)
Show SMILES CCOc1c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C26H32Cl2N6O5/c1-6-17(35)30-15-10-8-9-11-16(15)31-25-29-12-14-13-34(26(36)33(3)24(14)32-25)20-18(27)21(37-4)23(38-5)22(19(20)28)39-7-2/h6,12,15-16H,1,7-11,13H2,2-5H3,(H,30,35)(H,29,31,32)/t15-,16+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91865
PNG
(US9695132, I-66)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@H]4CCCC[C@H]4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H32Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-7,10-11,14-15,20-21H,1,8-9,12-13,16-17H2,2-3H3,(H,34,39)(H,33,35,36)/t20-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100953
PNG
(US9695132, I-240)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@H]3COC[C@H]3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C23H23Cl2N5O5/c1-5-17(31)27-13-9-35-10-14(13)28-23-26-8-11-6-12(22(32)30(2)21(11)29-23)18-19(24)15(33-3)7-16(34-4)20(18)25/h5-8,13-14H,1,9-10H2,2-4H3,(H,27,31)(H,26,28,29)/t13-,14+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100365
PNG
(US9695132, I-209)
Show SMILES COc1ccc(cc1)N1Cc2cnc(NC3COCC3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C21H24N6O4/c1-4-18(28)23-16-11-31-12-17(16)24-20-22-9-13-10-27(21(29)26(2)19(13)25-20)14-5-7-15(30-3)8-6-14/h4-9,16-17H,1,10-12H2,2-3H3,(H,23,28)(H,22,24,25)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88568
PNG
(US9695132, I-10)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)C(F)(F)F)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C31H25Cl2F3N6O4/c1-4-24(43)38-21-12-19(31(34,35)36)10-11-20(21)39-29-37-14-18-16-41(27-25(32)22(45-2)13-23(46-3)26(27)33)30(44)42(28(18)40-29)15-17-8-6-5-7-9-17/h4-14H,1,15-16H2,2-3H3,(H,38,43)(H,37,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%