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Patent code US9695149

Compile Data Set for Download or QSAR

Found 235 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145818
PNG
(US8952177, 174 | US9089569, 174 | US9695149, 174)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1S/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/m0/s1
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0.340n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145820
PNG
(US8952177, 176 | US9089569, 176 | US9695149, 176)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1S/C33H36F2N4O3/c1-21-16-28(35)30(36-18-21)20-42-25-10-11-29-31(17-25)39(32(37-29)26-4-2-3-5-27(26)33(40)41)19-22-6-8-24(9-7-22)38-14-12-23(34)13-15-38/h6-11,16-18,23,26-27H,2-5,12-15,19-20H2,1H3,(H,40,41)/t26-,27+/m0/s1
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0.420n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145785
PNG
(US8952177, 139 | US9089569, 139 | US9695149, 139)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1
Show InChI InChI=1S/C35H31F4N3O3/c1-21-16-29(36)31(40-18-21)20-45-26-14-15-30-32(17-26)42(33(41-30)27-4-2-3-5-28(27)34(43)44)19-22-6-8-23(9-7-22)24-10-12-25(13-11-24)35(37,38)39/h6-18,27-28H,2-5,19-20H2,1H3,(H,43,44)/t27-,28+/m0/s1
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0.470n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145770
PNG
(US8952177, 124 | US9089569, 124 | US9695149, 124)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1
Show InChI InChI=1S/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19-/m0/s1
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0.520n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145769
PNG
(US8952177, 123 | US9089569, 123 | US9695149, 123)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1
Show InChI InChI=1S/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19+/m1/s1
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0.610n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145782
PNG
(US8952177, 136 | US9089569, 136 | US9695149, 136)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C28H29BrFN3O3/c1-4-28(5-2,27(34)35)14-26-32-23-11-10-21(36-17-24-22(30)12-18(3)15-31-24)13-25(23)33(26)16-19-6-8-20(29)9-7-19/h6-13,15H,4-5,14,16-17H2,1-3H3,(H,34,35)
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0.640n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145783
PNG
(US8952177, 137 | US9089569, 137 | US9695149, 137)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1
Show InChI InChI=1S/C35H29F6N3O3/c1-19-12-29(38)31(42-16-19)18-47-23-10-11-30-32(15-23)44(33(43-30)24-4-2-3-5-25(24)34(45)46)17-26-27(36)13-21(14-28(26)37)20-6-8-22(9-7-20)35(39,40)41/h6-16,24-25H,2-5,17-18H2,1H3,(H,45,46)/t24-,25+/m0/s1
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0.660n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145657
PNG
(US8952177, 11 | US9089569, 11 | US9695149, 11)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4F)c3c2)nc1
Show InChI InChI=1S/C28H27BrFN3O3/c1-17-6-9-20(31-14-17)16-36-21-10-11-25-26(13-21)33(15-18-7-8-19(29)12-24(18)30)27(32-25)22-4-2-3-5-23(22)28(34)35/h6-14,22-23H,2-5,15-16H2,1H3,(H,34,35)/t22-,23+/m1/s1
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0.740n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145817
PNG
(US8952177, 173 | US8952177, 175 | US9089569, 175 |...)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1S/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/m1/s1
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0.820n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145816
PNG
(US8952177, 172 | US9089569, 172 | US9695149, 172)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1S/C33H34F4N4O3/c1-19-12-28(37)30(38-16-19)18-44-22-6-7-29-31(15-22)41(32(39-29)23-4-2-3-5-24(23)33(42)43)17-25-26(35)13-21(14-27(25)36)40-10-8-20(34)9-11-40/h6-7,12-16,20,23-24H,2-5,8-11,17-18H2,1H3,(H,42,43)/t23-,24+/m1/s1
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0.840n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM102301
PNG
(US9695149, 192)
Show SMILES Cc1cnc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(CC4)C(F)(F)F)c3c2)c(F)c1
Show InChI InChI=1S/C34H35F5N4O3/c1-20-14-28(36)30(40-17-20)19-46-24-8-9-29-31(16-24)43(32(41-29)25-4-2-3-5-26(25)33(44)45)18-21-6-7-23(15-27(21)35)42-12-10-22(11-13-42)34(37,38)39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,44,45)/t25?,26-/m1/s1
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0.950n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145807
PNG
(US8952177, 163 | US9089569, 163 | US9695149, 163)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)(F)C4)c3c2)nc1
Show InChI InChI=1S/C32H33F3N4O3/c1-20-6-8-22(36-16-20)18-42-24-10-11-28-29(15-24)39(30(37-28)25-4-2-3-5-26(25)31(40)41)17-21-7-9-23(14-27(21)33)38-13-12-32(34,35)19-38/h6-11,14-16,25-26H,2-5,12-13,17-19H2,1H3,(H,40,41)/t25-,26+/m0/s1
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0.960n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145772
PNG
(US8952177, 126 | US9089569, 126 | US9695149, 126)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1
Show InChI InChI=1S/C28H26BrF2N3O3/c1-16-6-7-18(32-13-16)15-37-19-8-9-25-26(12-19)34(14-22-23(30)10-17(29)11-24(22)31)27(33-25)20-4-2-3-5-21(20)28(35)36/h6-13,20-21H,2-5,14-15H2,1H3,(H,35,36)/t20-,21+/m0/s1
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145821
PNG
(US8952177, 177 | US9089569, 177 | US9695149, 177)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/m1/s1
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145771
PNG
(US8952177, 125 | US9089569, 125 | US9695149, 125)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1
Show InChI InChI=1S/C28H27BrFN3O3/c1-17-12-23(30)25(31-14-17)16-36-20-10-11-24-26(13-20)33(15-18-6-8-19(29)9-7-18)27(32-24)21-4-2-3-5-22(21)28(34)35/h6-14,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/m1/s1
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145739
PNG
(US8952177, 93 | US9089569, 93 | US9695149, 93)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1
Show InChI InChI=1S/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/m1/s1
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145822
PNG
(US8952177, 178 | US9089569, 178 | US9695149, 178)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/m1/s1
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1.20n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145839
PNG
(US8952177, 147 | US9089569, 147 | US9695149, 147)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1
Show InChI InChI=1S/C35H32F3N3O3/c1-22-6-15-27(39-19-22)21-44-28-16-17-31-32(18-28)41(33(40-31)29-4-2-3-5-30(29)34(42)43)20-23-7-9-24(10-8-23)25-11-13-26(14-12-25)35(36,37)38/h6-19,29-30H,2-5,20-21H2,1H3,(H,42,43)/t29-,30+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145823
PNG
(US8952177, 179 | US9089569, 179 | US9695149, 179)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CCCCC4)c3c2)c(F)c1
Show InChI InChI=1S/C33H37FN4O3/c1-22-17-28(34)30(35-19-22)21-41-25-13-14-29-31(18-25)38(32(36-29)26-7-3-4-8-27(26)33(39)40)20-23-9-11-24(12-10-23)37-15-5-2-6-16-37/h9-14,17-19,26-27H,2-8,15-16,20-21H2,1H3,(H,39,40)/t26-,27+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145835
PNG
(US8952177, 2 | US9695149, 2)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1
Show InChI InChI=1S/C28H28BrN3O3/c1-18-6-11-21(30-15-18)17-35-22-12-13-25-26(14-22)32(16-19-7-9-20(29)10-8-19)27(31-25)23-4-2-3-5-24(23)28(33)34/h6-15,23-24H,2-5,16-17H2,1H3,(H,33,34)/t23-,24+/m1/s1
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1.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145731
PNG
(US8952177, 85 | US9089569, 85 | US9695149, 85)
Show SMILES Cn1cc(F)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1
Show InChI InChI=1S/C27H25F5N4O4/c1-35-13-21(29)23(34-35)14-39-16-8-9-22-24(11-16)36(25(33-22)18-4-2-3-5-19(18)26(37)38)12-15-6-7-17(10-20(15)28)40-27(30,31)32/h6-11,13,18-19H,2-5,12,14H2,1H3,(H,37,38)/t18-,19+/m1/s1
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1.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145673
PNG
(US8952177, 27 | US8952177, 28 | US9089569, 32 | US...)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1
Show InChI InChI=1S/C29H28F3N3O4/c1-18-6-9-20(33-15-18)17-38-22-12-13-25-26(14-22)35(16-19-7-10-21(11-8-19)39-29(30,31)32)27(34-25)23-4-2-3-5-24(23)28(36)37/h6-15,23-24H,2-5,16-17H2,1H3,(H,36,37)/t23-,24+/m0/s1
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1.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145794
PNG
(US8952177, 150 | US9089569, 150 | US9695149, 150)
Show SMILES Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4cccc(c4)-c4ccc(cc4)C(F)(F)F)c3c2)n1
Show InChI InChI=1S/C33H31F3N4O3/c1-39-16-15-25(38-39)20-43-26-13-14-29-30(18-26)40(31(37-29)27-7-2-3-8-28(27)32(41)42)19-21-5-4-6-23(17-21)22-9-11-24(12-10-22)33(34,35)36/h4-6,9-18,27-28H,2-3,7-8,19-20H2,1H3,(H,41,42)/t27-,28+/m1/s1
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1.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145681
PNG
(US8952177, 35 | US9089569, 35 | US9695149, 35)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1
Show InChI InChI=1S/C35H32F3N3O3/c1-22-6-15-27(39-19-22)21-44-28-16-17-31-32(18-28)41(33(40-31)29-4-2-3-5-30(29)34(42)43)20-23-7-9-24(10-8-23)25-11-13-26(14-12-25)35(36,37)38/h6-19,29-30H,2-5,20-21H2,1H3,(H,42,43)/t29?,30-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145811
PNG
(US8952177, 167 | US9089569, 167 | US9695149, 167)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4F)N4CC(F)(F)C4)c3c2)nc1
Show InChI InChI=1S/C31H31F3N4O3/c1-19-6-8-21(35-14-19)16-41-23-10-11-27-28(13-23)38(29(36-27)24-4-2-3-5-25(24)30(39)40)15-20-7-9-22(12-26(20)32)37-17-31(33,34)18-37/h6-14,24-25H,2-5,15-18H2,1H3,(H,39,40)/t24-,25+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145682
PNG
(US8952177, 36 | US8952177, 45 | US9089569, 36 | US...)
Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1
Show InChI InChI=1S/C27H27F3N4O4/c1-33-13-12-18(32-33)16-37-20-10-11-23-24(14-20)34(15-17-6-8-19(9-7-17)38-27(28,29)30)25(31-23)21-4-2-3-5-22(21)26(35)36/h6-14,21-22H,2-5,15-16H2,1H3,(H,35,36)/t21?,22-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145837
PNG
(US8952177, 7 | US9695149, 7)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1
Show InChI InChI=1S/C28H28BrN3O3/c1-18-6-11-21(30-15-18)17-35-22-12-13-25-26(14-22)32(16-19-7-9-20(29)10-8-19)27(31-25)23-4-2-3-5-24(23)28(33)34/h6-15,23-24H,2-5,16-17H2,1H3,(H,33,34)/t23-,24-/m1/s1
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2.20n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145740
PNG
(US8952177, 94 | US9089569, 94 | US9695149, 94)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4F)c3c2)n1
Show InChI InChI=1S/C26H25BrF2N4O3/c1-32-9-8-17(31-32)14-36-18-11-22(29)24-23(12-18)33(13-15-6-7-16(27)10-21(15)28)25(30-24)19-4-2-3-5-20(19)26(34)35/h6-12,19-20H,2-5,13-14H2,1H3,(H,34,35)/t19-,20+/m1/s1
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2.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM103500
PNG
(US9695149, 236)
Show SMILES Cn1ccc(COc2cc(F)c3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)(F)C4)c3c2)n1
Show InChI InChI=1S/C30H32F3N5O3/c1-36-12-10-20(35-36)17-41-22-14-25(31)27-26(15-22)38(28(34-27)23-4-2-3-5-24(23)29(39)40)16-19-6-8-21(9-7-19)37-13-11-30(32,33)18-37/h6-10,12,14-15,23-24H,2-5,11,13,16-18H2,1H3,(H,39,40)/t23?,24-/m1/s1
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2.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145796
PNG
(US8952177, 152 | US9089569, 152 | US9695149, 152)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)(F)C4)c3c2)nc1
Show InChI InChI=1S/C32H34F2N4O3/c1-21-6-9-23(35-17-21)19-41-25-12-13-28-29(16-25)38(30(36-28)26-4-2-3-5-27(26)31(39)40)18-22-7-10-24(11-8-22)37-15-14-32(33,34)20-37/h6-13,16-17,26-27H,2-5,14-15,18-20H2,1H3,(H,39,40)/t26?,27-/m1/s1
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2.40n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145651
PNG
(US8952177, 4 | US9089569, 4 | US9695149, 4)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(Br)c(F)c4)c3c2)nc1
Show InChI InChI=1S/C28H27BrFN3O3/c1-17-6-8-19(31-14-17)16-36-20-9-11-25-26(13-20)33(15-18-7-10-23(29)24(30)12-18)27(32-25)21-4-2-3-5-22(21)28(34)35/h6-14,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21?,22-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145784
PNG
(US8952177, 138 | US9089569, 138 | US9695149, 138)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)nc1
Show InChI InChI=1S/C35H30F5N3O3/c1-20-6-11-24(41-17-20)19-46-25-12-13-31-32(16-25)43(33(42-31)26-4-2-3-5-27(26)34(44)45)18-28-29(36)14-22(15-30(28)37)21-7-9-23(10-8-21)35(38,39)40/h6-17,26-27H,2-5,18-19H2,1H3,(H,44,45)/t26-,27+/m0/s1
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2.5n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145755
PNG
(US8952177, 109 | US9089569, 109 | US9695149, 109)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1
Show InChI InChI=1S/C30H30F3N3O4/c1-18-7-9-21(34-15-18)17-39-22-10-11-25-26(14-22)36(28(35-25)23-5-3-4-6-24(23)29(37)38)16-20-8-12-27(19(2)13-20)40-30(31,32)33/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,37,38)/t23-,24+/m1/s1
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2.60n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145727
PNG
(US8952177, 81 | US9089569, 81 | US9695149, 81)
Show SMILES Cn1cc(Cl)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1
Show InChI InChI=1S/C26H26BrClN4O3/c1-31-14-21(28)23(30-31)15-35-18-10-11-22-24(12-18)32(13-16-6-8-17(27)9-7-16)25(29-22)19-4-2-3-5-20(19)26(33)34/h6-12,14,19-20H,2-5,13,15H2,1H3,(H,33,34)/t19-,20+/m1/s1
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2.90n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145778
PNG
(US8952177, 132 | US9089569, 132 | US9695149, 132)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4[C@H](C(O)=O)C4(C)C)n(Cc4ccc(Br)cc4)c3c2)c(F)c1
Show InChI InChI=1S/C27H25BrFN3O3/c1-15-10-19(29)21(30-12-15)14-35-18-8-9-20-22(11-18)32(13-16-4-6-17(28)7-5-16)25(31-20)23-24(26(33)34)27(23,2)3/h4-12,23-24H,13-14H2,1-3H3,(H,33,34)/t23-,24+/m0/s1
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2.90n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145705
PNG
(US8952177, 59 | US9089569, 59 | US9695149, 59)
Show SMILES Cc1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1
Show InChI InChI=1S/C28H27BrFN3O3/c1-17-6-11-20(31-14-17)16-36-21-12-24(30)26-25(13-21)33(15-18-7-9-19(29)10-8-18)27(32-26)22-4-2-3-5-23(22)28(34)35/h6-14,22-23H,2-5,15-16H2,1H3,(H,34,35)/t22-,23+/m1/s1
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2.90n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145786
PNG
(US8952177, 140 | US9089569, 140 | US9695149, 140)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1
Show InChI InChI=1S/C28H26BrF2N3O3/c1-16-6-7-18(32-13-16)15-37-19-8-9-25-26(12-19)34(14-22-23(30)10-17(29)11-24(22)31)27(33-25)20-4-2-3-5-21(20)28(35)36/h6-13,20-21H,2-5,14-15H2,1H3,(H,35,36)/t20-,21-/m0/s1
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3n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145801
PNG
(US8952177, 157 | US9089569, 157 | US9695149, 157)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CCCCC4)c3c2)nc1
Show InChI InChI=1S/C33H38N4O3/c1-23-9-12-25(34-20-23)22-40-27-15-16-30-31(19-27)37(32(35-30)28-7-3-4-8-29(28)33(38)39)21-24-10-13-26(14-11-24)36-17-5-2-6-18-36/h9-16,19-20,28-29H,2-8,17-18,21-22H2,1H3,(H,38,39)/t28-,29+/m1/s1
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3n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145699
PNG
(US8952177, 53 | US9089569, 53 | US9695149, 53)
Show SMILES Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1
Show InChI InChI=1S/C27H26F4N4O4/c1-34-11-10-17(33-34)15-38-18-8-9-23-24(13-18)35(25(32-23)20-4-2-3-5-21(20)26(36)37)14-16-6-7-19(12-22(16)28)39-27(29,30)31/h6-13,20-21H,2-5,14-15H2,1H3,(H,36,37)/t20-,21+/m0/s1
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3n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145824
PNG
(US8952177, 180 | US8952177, 182 | US9089569, 182 |...)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O
Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)
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3n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM65542
PNG
(US9695149, 80)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)-c4ncc(Cl)cn4)c3c2)nc1
Show InChI InChI=1S/C32H30ClN5O3/c1-20-6-11-24(34-15-20)19-41-25-12-13-28-29(14-25)38(31(37-28)26-4-2-3-5-27(26)32(39)40)18-21-7-9-22(10-8-21)30-35-16-23(33)17-36-30/h6-17,26-27H,2-5,18-19H2,1H3,(H,39,40)/t26-,27+/m0/s1
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3.30n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145741
PNG
(US8952177, 95 | US9089569, 95 | US9695149, 95)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1
Show InChI InChI=1S/C27H26F4N4O4/c1-34-11-10-17(33-34)15-38-19-12-22(28)24-23(13-19)35(14-16-6-8-18(9-7-16)39-27(29,30)31)25(32-24)20-4-2-3-5-21(20)26(36)37/h6-13,20-21H,2-5,14-15H2,1H3,(H,36,37)/t20-,21+/m1/s1
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3.60n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145798
PNG
(US8952177, 154 | US9089569, 154 | US9695149, 154)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)(F)CC4)c3c2)nc1
Show InChI InChI=1S/C33H36F2N4O3/c1-22-6-9-24(36-19-22)21-42-26-12-13-29-30(18-26)39(31(37-29)27-4-2-3-5-28(27)32(40)41)20-23-7-10-25(11-8-23)38-16-14-33(34,35)15-17-38/h6-13,18-19,27-28H,2-5,14-17,20-21H2,1H3,(H,40,41)/t27?,28-/m1/s1
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3.70n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145804
PNG
(US8952177, 160 | US9089569, 160 | US9695149, 160)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CC(F)(F)C4)c3c2)nc1
Show InChI InChI=1S/C31H32F2N4O3/c1-20-6-9-22(34-15-20)17-40-24-12-13-27-28(14-24)37(29(35-27)25-4-2-3-5-26(25)30(38)39)16-21-7-10-23(11-8-21)36-18-31(32,33)19-36/h6-15,25-26H,2-5,16-19H2,1H3,(H,38,39)/t25-,26+/m1/s1
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3.80n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM102917
PNG
(US9695149, 222)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4cccc(c4)N4CCCC(F)(F)C4)c3c2)nc1
Show InChI InChI=1S/C33H36F2N4O3/c1-22-10-11-24(36-18-22)20-42-26-12-13-29-30(17-26)39(31(37-29)27-8-2-3-9-28(27)32(40)41)19-23-6-4-7-25(16-23)38-15-5-14-33(34,35)21-38/h4,6-7,10-13,16-18,27-28H,2-3,5,8-9,14-15,19-21H2,1H3,(H,40,41)/t27?,28-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM102384
PNG
(US9695149, 209)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4cc(ccc4F)N4CCCCC4)c3c2)nc1
Show InChI InChI=1S/C33H37FN4O3/c1-22-9-10-24(35-19-22)21-41-26-12-14-30-31(18-26)38(32(36-30)27-7-3-4-8-28(27)33(39)40)20-23-17-25(11-13-29(23)34)37-15-5-2-6-16-37/h9-14,17-19,27-28H,2-8,15-16,20-21H2,1H3,(H,39,40)/t27?,28-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145650
PNG
(US8952177, 1 | US8952177, 5 | US8952177, 6 | US908...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1
Show InChI InChI=1S/C28H28BrN3O3/c1-18-6-11-21(30-15-18)17-35-22-12-13-25-26(14-22)32(16-19-7-9-20(29)10-8-19)27(31-25)23-4-2-3-5-24(23)28(33)34/h6-15,23-24H,2-5,16-17H2,1H3,(H,33,34)/t23?,24-/m0/s1
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3.80n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145686
PNG
(US8952177, 40 | US8952177, 41 | US9089569, 41 | US...)
Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1
Show InChI InChI=1S/C26H27BrN4O3/c1-30-13-12-19(29-30)16-34-20-10-11-23-24(14-20)31(15-17-6-8-18(27)9-7-17)25(28-23)21-4-2-3-5-22(21)26(32)33/h6-14,21-22H,2-5,15-16H2,1H3,(H,32,33)/t21?,22-/m1/s1
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3.90n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145805
PNG
(US8952177, 161 | US9089569, 161 | US9695149, 161)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)(F)CC4)c3c2)nc1
Show InChI InChI=1S/C33H35F3N4O3/c1-21-6-8-23(37-18-21)20-43-25-10-11-29-30(17-25)40(31(38-29)26-4-2-3-5-27(26)32(41)42)19-22-7-9-24(16-28(22)34)39-14-12-33(35,36)13-15-39/h6-11,16-18,26-27H,2-5,12-15,19-20H2,1H3,(H,41,42)/t26?,27-/m1/s1
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4n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145677
PNG
(US8952177, 31 | US9089569, 31 | US9695149, 31)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1
Show InChI InChI=1S/C29H28F3N3O4/c1-18-6-9-20(33-15-18)17-38-22-12-13-25-26(14-22)35(16-19-7-10-21(11-8-19)39-29(30,31)32)27(34-25)23-4-2-3-5-24(23)28(36)37/h6-15,23-24H,2-5,16-17H2,1H3,(H,36,37)/t23-,24-/m1/s1
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4.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%