BindingDB logo
myBDB logout

Patent code US9695160

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101734
PNG
(US9695160, 31)
Show SMILES CSc1nccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)n1
Show InChI InChI=1S/C23H24F3N5O2S/c1-15-3-6-20(33-15)21(32)29-18-13-16(23(24,25)26)4-5-19(18)31-11-9-30(10-12-31)14-17-7-8-27-22(28-17)34-2/h3-8,13H,9-12,14H2,1-2H3,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.90n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101825
PNG
(US9695160, 39)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)20-4-5-23(34-13-11-33(12-14-34)18-21-3-1-2-10-31-21)22(17-20)32-26(35)25-7-6-24(37-25)19-8-15-36-16-9-19/h1-7,10,17,19H,8-9,11-16,18H2,(H,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.60n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.18n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101676
PNG
(US9695160, 20)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-17-7-10-22(32-17)23(31)28-20-15-19(24(25,26)27)8-9-21(20)30-13-11-29(12-14-30)16-18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101690
PNG
(US9695160, 21)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-8-9-24(35-15-13-34(14-16-35)19-20-5-2-1-3-6-20)23(17-22)33-27(36)26-11-10-25(37-26)21-7-4-12-32-18-21/h1-12,17-18H,13-16,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.60n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101824
PNG
(US9695160, 38)
Show SMILES OCc1cccc(c1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O3/c30-29(31,32)22-7-8-25(36-14-12-35(13-15-36)18-23-6-1-2-11-33-23)24(17-22)34-28(38)27-10-9-26(39-27)21-5-3-4-20(16-21)19-37/h1-11,16-17,37H,12-15,18-19H2,(H,34,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101654
PNG
(US9695160, 14)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccncc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-1-2-23(35-15-13-34(14-16-35)18-19-5-9-31-10-6-19)22(17-21)33-26(36)25-4-3-24(37-25)20-7-11-32-12-8-20/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.18n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101713
PNG
(US9695160, 25)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-6-7-23(35-14-12-34(13-15-35)18-21-5-1-2-11-32-21)22(16-20)33-26(36)25-9-8-24(37-25)19-4-3-10-31-17-19/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101674
PNG
(US9695160, 19)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)18-8-9-20(19(15-18)27-22(30)21-7-4-14-31-21)29-12-10-28(11-13-29)16-17-5-2-1-3-6-17/h1-9,14-15H,10-13,16H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101671
PNG
(US9695160, 18)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccc3[nH]ccc3c2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-7-26(38-15-13-37(14-16-38)19-23-3-1-2-11-34-23)25(18-22)36-29(39)28-9-8-27(40-28)21-4-6-24-20(17-21)10-12-35-24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101695
PNG
(US9695160, 22)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-6-7-24(35-16-14-34(15-17-35)19-20-4-2-1-3-5-20)23(18-22)33-27(36)26-9-8-25(37-26)21-10-12-32-13-11-21/h1-13,18H,14-17,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101649
PNG
(US9695160, 13)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cccnc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-3-4-23(35-14-12-34(13-15-35)18-19-2-1-9-32-17-19)22(16-21)33-26(36)25-6-5-24(37-25)20-7-10-31-11-8-20/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101657
PNG
(US9695160, 15)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-19(18(14-16)27-21(30)20-5-3-13-31-20)29-11-9-28(10-12-29)15-17-4-1-2-8-26-17/h1-8,13-14H,9-12,15H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101659
PNG
(US9695160, 16)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O2/c1-16-5-8-21(32-16)22(31)28-19-14-17(23(24,25)26)6-7-20(19)30-12-10-29(11-13-30)15-18-4-2-3-9-27-18/h2-9,14H,10-13,15H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM221073
PNG
(SPHINX scaffold, 3 | US9695160, SPHINX7)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F
Show InChI InChI=1S/C25H28F3N5O2/c1-31(2)11-12-32-13-15-33(16-14-32)21-4-3-19(25(26,27)28)17-20(21)30-24(34)23-6-5-22(35-23)18-7-9-29-10-8-18/h3-10,17H,11-16H2,1-2H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101660
PNG
(US9695160, 17)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)21-9-10-24(35-16-14-34(15-17-35)19-22-8-4-5-13-32-22)23(18-21)33-27(36)26-12-11-25(37-26)20-6-2-1-3-7-20/h1-13,18H,14-17,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 111n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101832
PNG
(US9695160, 45)
Show SMILES OCc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3/c24-23(25,26)16-4-6-20(19(13-16)28-22(32)21-7-5-18(15-31)33-21)30-11-9-29(10-12-30)14-17-3-1-2-8-27-17/h1-8,13,31H,9-12,14-15H2,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 119n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101829
PNG
(US9695160, 42)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-6-26(25(17-22)36-29(39)28-8-7-27(40-28)20-9-11-34-12-10-20)38-15-13-37(14-16-38)19-21-18-35-24-4-2-1-3-23(21)24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 164n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101815
PNG
(US9695160, 36)
Show SMILES COc1cc(ccn1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O3/c1-38-26-16-19(9-11-33-26)24-7-8-25(39-24)27(37)34-22-17-20(28(29,30)31)5-6-23(22)36-14-12-35(13-15-36)18-21-4-2-3-10-32-21/h2-11,16-17H,12-15,18H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 170n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101830
PNG
(US9695160, 43)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnccn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-3-4-18(17(12-15)27-20(30)19-2-1-11-31-19)29-9-7-28(8-10-29)14-16-13-25-5-6-26-16/h1-6,11-13H,7-10,14H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 183n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101822
PNG
(US9695160, 37)
Show SMILES COc1ccc(cn1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O3/c1-38-26-10-5-19(17-33-26)24-8-9-25(39-24)27(37)34-22-16-20(28(29,30)31)6-7-23(22)36-14-12-35(13-15-36)18-21-4-2-3-11-32-21/h2-11,16-17H,12-15,18H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 323n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101728
PNG
(US9695160, 30)
Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H27F3N4O3/c1-38-23-5-2-20(3-6-23)19-35-14-16-36(17-15-35)25-7-4-22(29(30,31)32)18-24(25)34-28(37)27-9-8-26(39-27)21-10-12-33-13-11-21/h2-13,18H,14-17,19H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 336n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM221070
PNG
(SPHINX | US9695160, SPHINX)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N2O3/c1-11-2-5-15(25-11)16(23)21-13-10-12(17(18,19)20)3-4-14(13)22-6-8-24-9-7-22/h2-5,10H,6-9H2,1H3,(H,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 440n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101828
PNG
(US9695160, 41)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1nc(c[nH]1)-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O/c1-29-9-11-30(12-10-29)19-8-7-16(22(23,24)25)13-17(19)28-21(31)20-26-14-18(27-20)15-5-3-2-4-6-15/h2-8,13-14H,9-12H2,1H3,(H,26,27)(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 493n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101737
PNG
(US9695160, 32)
Show SMILES COc1cccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)c1
Show InChI InChI=1S/C29H27F3N4O3/c1-38-23-4-2-3-20(17-23)19-35-13-15-36(16-14-35)25-6-5-22(29(30,31)32)18-24(25)34-28(37)27-8-7-26(39-27)21-9-11-33-12-10-21/h2-12,17-18H,13-16,19H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.55E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101703
PNG
(US9695160, 24)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2ccc3[nH]ccc3c2)c1
Show InChI InChI=1S/C31H27F3N4O2/c32-31(33,34)24-7-9-27(38-16-14-37(15-17-38)20-21-4-2-1-3-5-21)26(19-24)36-30(39)29-11-10-28(40-29)23-6-8-25-22(18-23)12-13-35-25/h1-13,18-19,35H,14-17,20H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.51E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101696
PNG
(US9695160, 23)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C29H26F3N3O2/c30-29(31,32)23-11-12-25(35-17-15-34(16-18-35)20-21-7-3-1-4-8-21)24(19-23)33-28(36)27-14-13-26(37-27)22-9-5-2-6-10-22/h1-14,19H,15-18,20H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.01E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101739
PNG
(US9695160, 33)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2cnc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-9-10-23(35-14-12-34(13-15-35)18-21-8-4-5-11-31-21)22(16-20)33-25(36)24-17-32-26(37-24)19-6-2-1-3-7-19/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.03E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101826
PNG
(US9695160, 40)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cccs1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N3OS/c1-22-6-8-23(9-7-22)14-5-4-12(17(18,19)20)11-13(14)21-16(24)15-3-2-10-25-15/h2-5,10-11H,6-9H2,1H3,(H,21,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.69E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101740
PNG
(US9695160, 34)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2nc(no2)-c2ccccc2)c1
Show InChI InChI=1S/C26H23F3N6O2/c27-26(28,29)19-9-10-22(35-14-12-34(13-15-35)17-20-8-4-5-11-30-20)21(16-19)31-24(36)25-32-23(33-37-25)18-6-2-1-3-7-18/h1-11,16H,12-15,17H2,(H,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.31E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101831
PNG
(US9695160, 44)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ncn[nH]2)c1
Show InChI InChI=1S/C20H20F3N7O/c21-20(22,23)14-4-5-17(16(11-14)27-19(31)18-25-13-26-28-18)30-9-7-29(8-10-30)12-15-3-1-2-6-24-15/h1-6,11,13H,7-10,12H2,(H,27,31)(H,25,26,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.41E+3n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101715
PNG
(US9695160, 27)
Show SMILES Cc1cnc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O2/c1-15-13-27-21(32-15)20(31)28-18-12-16(22(23,24)25)5-6-19(18)30-10-8-29(9-11-30)14-17-4-2-3-7-26-17/h2-7,12-13H,8-11,14H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101714
PNG
(US9695160, 26)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2nnc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C26H23F3N6O2/c27-26(28,29)19-9-10-22(35-14-12-34(13-15-35)17-20-8-4-5-11-30-20)21(16-19)31-23(36)25-33-32-24(37-25)18-6-2-1-3-7-18/h1-11,16H,12-15,17H2,(H,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101722
PNG
(US9695160, 29)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N7O2/c26-25(27,28)18-4-5-21(35-13-11-34(12-14-35)16-19-3-1-2-8-30-19)20(15-18)31-22(36)24-33-32-23(37-24)17-6-9-29-10-7-17/h1-10,15H,11-14,16H2,(H,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101814
PNG
(US9695160, 35)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2noc(n2)-c2ccccc2)c1
Show InChI InChI=1S/C25H22F3N6O3/c26-25(27,28)18-4-5-21(34-13-11-33(12-14-34)16-19-3-1-2-8-30-19)20(15-18)31-22(35)23-32-37-24(36-23)17-6-9-29-10-7-17/h1-10,15H,11-14,16H2,(H,31,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101720
PNG
(US9695160, 28)
Show SMILES Cc1nnc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N6O2/c1-14-27-28-20(32-14)19(31)26-17-12-15(21(22,23)24)5-6-18(17)30-10-8-29(9-11-30)13-16-4-2-3-7-25-16/h2-7,12H,8-11,13H2,1H3,(H,26,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



The University of Nottingham; NewSouth Innovations PTY Limited

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%