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Patent code US9695163

Compile Data Set for Download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor 2


(Homo sapiens (Human))
BDBM101857
PNG
(US9695163, 9)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@@H](O)C(F)F
Show InChI InChI=1S/C20H21F2N5O2S/c1-12-6-7-13(19-25-15(11-30-19)17(28)18(21)22)10-26(12)20(29)14-4-2-3-5-16(14)27-23-8-9-24-27/h2-5,8-9,11-13,17-18,28H,6-7,10H2,1H3/t12-,13-,17-/m1/s1
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US Patent
n/an/a 9.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101883
PNG
(US9695163, 20)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C20H25N5O2S2/c1-12-5-6-14(17-23-16(13(2)29-17)20(3,4)27)11-24(12)18(26)15-7-10-28-19(15)25-21-8-9-22-25/h7-10,12,14,27H,5-6,11H2,1-4H3/t12-,14-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101899
PNG
(US9695163, 25)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C24H29N3O2S/c1-15-9-10-17(21-26-20(16(2)30-21)23(3,4)29)13-27(15)22(28)18-7-5-6-8-19(18)24(14-25)11-12-24/h5-8,15,17,29H,9-13H2,1-4H3/t15-,17-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101911
PNG
(US9695163, 30)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C23H27N3O2S/c1-15-8-9-16(19-13-29-21(25-19)22(2,3)28)12-26(15)20(27)17-6-4-5-7-18(17)23(14-24)10-11-23/h4-7,13,15-16,28H,8-12H2,1-3H3/t15-,16-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM50108614
PNG
(CHEMBL3597959 | US9695163, 19)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H27N5O2S/c1-14-9-10-16(20-25-19(15(2)30-20)22(3,4)29)13-26(14)21(28)17-7-5-6-8-18(17)27-23-11-12-24-27/h5-8,11-12,14,16,29H,9-10,13H2,1-4H3/t14-,16-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM50108615
PNG
(CHEMBL3597958 | US9695163, 35)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(15-10-28-18(22-15)19(2,3)26)8-23(12)17(25)14-9-27-11-16(14)24-20-6-7-21-24/h6-7,9-13,26H,4-5,8H2,1-3H3/t12-,13-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM102051
PNG
(US9695163, 38)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H24FN5O2S/c1-13-4-5-14(17-12-30-20(25-17)21(2,3)29)11-26(13)19(28)16-7-6-15(22)10-18(16)27-23-8-9-24-27/h6-10,12-14,29H,4-5,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101910
PNG
(US9695163, 29)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C20H24N6O2S/c1-13-8-9-14(16-11-29-19(23-16)20(2,3)28)10-25(13)18(27)15-6-4-5-7-17(15)26-22-12-21-24-26/h4-7,11-14,28H,8-10H2,1-3H3/t13-,14-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101856
PNG
(US9695163, 7)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@@H](O)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2S/c1-12-6-7-13(18-26-15(11-31-18)17(29)20(21,22)23)10-27(12)19(30)14-4-2-3-5-16(14)28-24-8-9-25-28/h2-5,8-9,11-13,17,29H,6-7,10H2,1H3/t12-,13-,17-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101860
PNG
(US9695163, 11)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C23H27N3O2S/c1-15-8-9-16(20-25-19(13-29-20)22(2,3)28)12-26(15)21(27)17-6-4-5-7-18(17)23(14-24)10-11-23/h4-7,13,15-16,28H,8-12H2,1-3H3/t15-,16-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM102017
PNG
(US9695163, 37)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(15-11-28-18(22-15)19(2,3)26)10-23(12)16(25)14-6-9-27-17(14)24-20-7-8-21-24/h6-9,11-13,26H,4-5,10H2,1-3H3/t12-,13-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101864
PNG
(US9695163, 15)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(17-22-16(11-28-17)19(2,3)26)8-23(12)18(25)14-9-27-10-15(14)24-20-6-7-21-24/h6-7,9-13,26H,4-5,8H2,1-3H3/t12-,13-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101474
PNG
(US9695163, 5)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(19-24-18(13-29-19)21(2,3)28)12-25(14)20(27)16-6-4-5-7-17(16)26-22-10-11-23-26/h4-7,10-11,13-15,28H,8-9,12H2,1-3H3/t14-,15-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101862
PNG
(US9695163, 13)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H24FN5O2S/c1-13-4-5-14(19-25-18(12-30-19)21(2,3)29)11-26(13)20(28)16-7-6-15(22)10-17(16)27-23-8-9-24-27/h6-10,12-14,29H,4-5,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101898
PNG
(US9695163, 24)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C21H26N6O2S/c1-13-9-10-15(19-24-18(14(2)30-19)21(3,4)29)11-26(13)20(28)16-7-5-6-8-17(16)27-23-12-22-25-27/h5-8,12-13,15,29H,9-11H2,1-4H3/t13-,15-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101854
PNG
(US9695163, 10 | US9695163, 5)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(16-22-15(11-28-16)19(2,3)26)10-23(12)17(25)14-6-9-27-18(14)24-20-7-8-21-24/h6-9,11-13,26H,4-5,10H2,1-3H3/t12-,13-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101886
PNG
(US9695163, 22)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H26FN5O2S/c1-13-5-6-15(20-26-19(14(2)31-20)22(3,4)30)12-27(13)21(29)17-8-7-16(23)11-18(17)28-24-9-10-25-28/h7-11,13,15,30H,5-6,12H2,1-4H3/t13-,15-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM102006
PNG
(US9695163, 36)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(17-13-29-20(24-17)21(2,3)28)12-25(14)19(27)16-6-4-5-7-18(16)26-22-10-11-23-26/h4-7,10-11,13-15,28H,8-9,12H2,1-3H3/t14-,15-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101863
PNG
(US9695163, 14)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C20H24N6O2S/c1-13-8-9-14(18-23-17(11-29-18)20(2,3)28)10-25(13)19(27)15-6-4-5-7-16(15)26-22-12-21-24-26/h4-7,11-14,28H,8-10H2,1-3H3/t13-,14-/m1/s1
PDB

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n/an/a 21n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101866
PNG
(US9695163, 16)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(19-24-17(12-29-19)21(2,3)27)9-25(13)20(26)16-11-28-10-15(16)18-22-7-4-8-23-18/h4,7-8,10-14,27H,5-6,9H2,1-3H3/t13-,14-/m1/s1
PDB

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n/an/a 25n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101893
PNG
(US9695163, 23)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2S/c1-15-10-11-17(22-27-20(16(2)31-22)24(3,4)30)14-28(15)23(29)19-9-6-5-8-18(19)21-25-12-7-13-26-21/h5-9,12-13,15,17,30H,10-11,14H2,1-4H3/t15-,17-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101902
PNG
(US9695163, 28)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H26N4O2S2/c1-13-6-7-15(20-25-18(14(2)30-20)22(3,4)28)10-26(13)21(27)17-12-29-11-16(17)19-23-8-5-9-24-19/h5,8-9,11-13,15,28H,6-7,10H2,1-4H3/t13-,15-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101871
PNG
(US9695163, 17)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2S/c1-15-9-10-16(21-26-19(14-30-21)23(2,3)29)13-27(15)22(28)18-8-5-4-7-17(18)20-24-11-6-12-25-20/h4-8,11-12,14-16,29H,9-10,13H2,1-3H3/t15-,16-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101884
PNG
(US9695163, 21)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C20H25N5O2S2/c1-12-5-6-14(18-23-17(13(2)29-18)20(3,4)27)9-24(12)19(26)15-10-28-11-16(15)25-21-7-8-22-25/h7-8,10-12,14,27H,5-6,9H2,1-4H3/t12-,14-/m1/s1
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MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101900
PNG
(US9695163, 26)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1CS(C)(=O)=O)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H30N2O4S2/c1-14-10-11-16(20-23-19(15(2)29-20)22(3,4)26)12-24(14)21(25)18-9-7-6-8-17(18)13-30(5,27)28/h6-9,14,16,26H,10-13H2,1-5H3/t14-,16-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101983
PNG
(US9695163, 34)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1CS(C)(=O)=O)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H28N2O4S2/c1-14-9-10-15(18-12-28-20(22-18)21(2,3)25)11-23(14)19(24)17-8-6-5-7-16(17)13-29(4,26)27/h5-8,12,14-15,25H,9-11,13H2,1-4H3/t14-,15-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101861
PNG
(US9695163, 12)
Show SMILES COC(=O)c1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H26N2O4S/c1-13-9-10-14(18-22-17(12-28-18)21(2,3)26)11-23(13)19(24)15-7-5-6-8-16(15)20(25)27-4/h5-8,12-14,26H,9-11H2,1-4H3/t13-,14-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101834
PNG
(US9695163, 4)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1cnc(s1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(18-12-22-20(29-18)21(2,3)28)13-25(14)19(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15,28H,8-9,13H2,1-3H3/t14-,15-/m1/s1
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MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101835
PNG
(US9695163, 2)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(s1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(19-22-12-18(29-19)21(2,3)28)13-25(14)20(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15,28H,8-9,13H2,1-3H3/t14-,15-/m1/s1
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MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101901
PNG
(US9695163, 27)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H26N4O2S2/c1-13-6-7-15(20-25-18(14(2)30-20)22(3,4)28)12-26(13)21(27)16-8-11-29-17(16)19-23-9-5-10-24-19/h5,8-11,13,15,28H,6-7,12H2,1-4H3/t13-,15-/m1/s1
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n/an/a 87n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101918
PNG
(US9695163, 31)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(16-12-29-20(24-16)21(2,3)27)11-25(13)19(26)15-7-10-28-17(15)18-22-8-4-9-23-18/h4,7-10,12-14,27H,5-6,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a 90n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101920
PNG
(US9695163, 33)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2S/c1-15-9-10-16(19-14-30-22(26-19)23(2,3)29)13-27(15)21(28)18-8-5-4-7-17(18)20-24-11-6-12-25-20/h4-8,11-12,14-16,29H,9-10,13H2,1-3H3/t15-,16-/m1/s1
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n/an/a 102n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101874
PNG
(US9695163, 18)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(19-24-16(12-29-19)21(2,3)27)11-25(13)20(26)15-7-10-28-17(15)18-22-8-4-9-23-18/h4,7-10,12-14,27H,5-6,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a 114n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101919
PNG
(US9695163, 32)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(17-12-29-20(24-17)21(2,3)27)9-25(13)19(26)16-11-28-10-15(16)18-22-7-4-8-23-18/h4,7-8,10-14,27H,5-6,9H2,1-3H3/t13-,14-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101859
PNG
(US9695163, 8)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@H](O)C(F)F
Show InChI InChI=1S/C20H21F2N5O2S/c1-12-6-7-13(19-25-15(11-30-19)17(28)18(21)22)10-26(12)20(29)14-4-2-3-5-16(14)27-23-8-9-24-27/h2-5,8-9,11-13,17-18,28H,6-7,10H2,1H3/t12-,13-,17+/m1/s1
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n/an/a 133n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101858
PNG
(US9695163, 6)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@H](O)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2S/c1-12-6-7-13(18-26-15(11-31-18)17(29)20(21,22)23)10-27(12)19(30)14-4-2-3-5-16(14)28-24-8-9-25-28/h2-5,8-9,11-13,17,29H,6-7,10H2,1H3/t12-,13-,17+/m1/s1
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n/an/a 165n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101899
PNG
(US9695163, 25)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C24H29N3O2S/c1-15-9-10-17(21-26-20(16(2)30-21)23(3,4)29)13-27(15)22(28)18-7-5-6-8-19(18)24(14-25)11-12-24/h5-8,15,17,29H,9-13H2,1-4H3/t15-,17-/m1/s1
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n/an/a 240n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM50108614
PNG
(CHEMBL3597959 | US9695163, 19)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H27N5O2S/c1-14-9-10-16(20-25-19(15(2)30-20)22(3,4)29)13-26(14)21(28)17-7-5-6-8-18(17)27-23-11-12-24-27/h5-8,11-12,14,16,29H,9-10,13H2,1-4H3/t14-,16-/m1/s1
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MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101856
PNG
(US9695163, 7)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@@H](O)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2S/c1-12-6-7-13(18-26-15(11-31-18)17(29)20(21,22)23)10-27(12)19(30)14-4-2-3-5-16(14)28-24-8-9-25-28/h2-5,8-9,11-13,17,29H,6-7,10H2,1H3/t12-,13-,17-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101857
PNG
(US9695163, 9)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@@H](O)C(F)F
Show InChI InChI=1S/C20H21F2N5O2S/c1-12-6-7-13(19-25-15(11-30-19)17(28)18(21)22)10-26(12)20(29)14-4-2-3-5-16(14)27-23-8-9-24-27/h2-5,8-9,11-13,17-18,28H,6-7,10H2,1H3/t12-,13-,17-/m1/s1
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n/an/a 520n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101893
PNG
(US9695163, 23)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2S/c1-15-10-11-17(22-27-20(16(2)31-22)24(3,4)30)14-28(15)23(29)19-9-6-5-8-18(19)21-25-12-7-13-26-21/h5-9,12-13,15,17,30H,10-11,14H2,1-4H3/t15-,17-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101901
PNG
(US9695163, 27)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H26N4O2S2/c1-13-6-7-15(20-25-18(14(2)30-20)22(3,4)28)12-26(13)21(27)16-8-11-29-17(16)19-23-9-5-10-24-19/h5,8-11,13,15,28H,6-7,12H2,1-4H3/t13-,15-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101902
PNG
(US9695163, 28)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H26N4O2S2/c1-13-6-7-15(20-25-18(14(2)30-20)22(3,4)28)10-26(13)21(27)17-12-29-11-16(17)19-23-8-5-9-24-19/h5,8-9,11-13,15,28H,6-7,10H2,1-4H3/t13-,15-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101886
PNG
(US9695163, 22)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H26FN5O2S/c1-13-5-6-15(20-26-19(14(2)31-20)22(3,4)30)12-27(13)21(29)17-8-7-16(23)11-18(17)28-24-9-10-25-28/h7-11,13,15,30H,5-6,12H2,1-4H3/t13-,15-/m1/s1
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n/an/a 930n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101860
PNG
(US9695163, 11)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C23H27N3O2S/c1-15-8-9-16(20-25-19(13-29-20)22(2,3)28)12-26(15)21(27)17-6-4-5-7-18(17)23(14-24)10-11-23/h4-7,13,15-16,28H,8-12H2,1-3H3/t15-,16-/m1/s1
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n/an/a 950n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101883
PNG
(US9695163, 20)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C20H25N5O2S2/c1-12-5-6-14(17-23-16(13(2)29-17)20(3,4)27)11-24(12)18(26)15-7-10-28-19(15)25-21-8-9-22-25/h7-10,12,14,27H,5-6,11H2,1-4H3/t12-,14-/m1/s1
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n/an/a 970n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101866
PNG
(US9695163, 16)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(19-24-17(12-29-19)21(2,3)27)9-25(13)20(26)16-11-28-10-15(16)18-22-7-4-8-23-18/h4,7-8,10-14,27H,5-6,9H2,1-3H3/t13-,14-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101911
PNG
(US9695163, 30)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C23H27N3O2S/c1-15-8-9-16(19-13-29-21(25-19)22(2,3)28)12-26(15)20(27)17-6-4-5-7-18(17)23(14-24)10-11-23/h4-7,13,15-16,28H,8-12H2,1-3H3/t15-,16-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101645
PNG
(US9695163, 1)
Show SMILES CCOC(=O)c1cnc(s1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1
Show InChI InChI=1S/C21H23N5O3S/c1-3-29-21(28)18-12-22-19(30-18)15-9-8-14(2)25(13-15)20(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15H,3,8-9,13H2,1-2H3/t14-,15-/m1/s1
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n/an/a 1.51E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM102051
PNG
(US9695163, 38)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H24FN5O2S/c1-13-4-5-14(17-12-30-20(25-17)21(2,3)29)11-26(13)19(28)16-7-6-15(22)10-18(16)27-23-8-9-24-27/h6-10,12-14,29H,4-5,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a 2.05E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101862
PNG
(US9695163, 13)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H24FN5O2S/c1-13-4-5-14(19-25-18(12-30-19)21(2,3)29)11-26(13)20(28)16-7-6-15(22)10-17(16)27-23-8-9-24-27/h6-10,12-14,29H,4-5,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a 2.25E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101474
PNG
(US9695163, 5)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(19-24-18(13-29-19)21(2,3)28)12-25(14)20(27)16-6-4-5-7-17(16)26-22-10-11-23-26/h4-7,10-11,13-15,28H,8-9,12H2,1-3H3/t14-,15-/m1/s1
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n/an/a 2.25E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM102006
PNG
(US9695163, 36)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(17-13-29-20(24-17)21(2,3)28)12-25(14)19(27)16-6-4-5-7-18(16)26-22-10-11-23-26/h4-7,10-11,13-15,28H,8-9,12H2,1-3H3/t14-,15-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101898
PNG
(US9695163, 24)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C21H26N6O2S/c1-13-9-10-15(19-24-18(14(2)30-19)21(3,4)29)11-26(13)20(28)16-7-5-6-8-17(16)27-23-12-22-25-27/h5-8,12-13,15,29H,9-11H2,1-4H3/t13-,15-/m1/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM101646
PNG
(US9695163, 3)
Show SMILES C[C@@H]1CC[C@@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(s1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(19-22-12-18(29-19)21(2,3)28)13-25(14)20(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15,28H,8-9,13H2,1-3H3/t14-,15+/m1/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101884
PNG
(US9695163, 21)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C20H25N5O2S2/c1-12-5-6-14(18-23-17(13(2)29-18)20(3,4)27)9-24(12)19(26)15-10-28-11-16(15)25-21-7-8-22-25/h7-8,10-12,14,27H,5-6,9H2,1-4H3/t12-,14-/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101871
PNG
(US9695163, 17)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2S/c1-15-9-10-16(21-26-19(14-30-21)23(2,3)29)13-27(15)22(28)18-8-5-4-7-17(18)20-24-11-6-12-25-20/h4-8,11-12,14-16,29H,9-10,13H2,1-3H3/t15-,16-/m1/s1
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n/an/a 5.47E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM102017
PNG
(US9695163, 37)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(15-11-28-18(22-15)19(2,3)26)10-23(12)16(25)14-6-9-27-17(14)24-20-7-8-21-24/h6-9,11-13,26H,4-5,10H2,1-3H3/t12-,13-/m1/s1
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n/an/a 7.20E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101854
PNG
(US9695163, 10 | US9695163, 5)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(16-22-15(11-28-16)19(2,3)26)10-23(12)17(25)14-6-9-27-18(14)24-20-7-8-21-24/h6-9,11-13,26H,4-5,10H2,1-3H3/t12-,13-/m1/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101834
PNG
(US9695163, 4)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1cnc(s1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(18-12-22-20(29-18)21(2,3)28)13-25(14)19(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15,28H,8-9,13H2,1-3H3/t14-,15-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101861
PNG
(US9695163, 12)
Show SMILES COC(=O)c1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H26N2O4S/c1-13-9-10-14(18-22-17(12-28-18)21(2,3)26)11-23(13)19(24)15-7-5-6-8-16(15)20(25)27-4/h5-8,12-14,26H,9-11H2,1-4H3/t13-,14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101645
PNG
(US9695163, 1)
Show SMILES CCOC(=O)c1cnc(s1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1
Show InChI InChI=1S/C21H23N5O3S/c1-3-29-21(28)18-12-22-19(30-18)15-9-8-14(2)25(13-15)20(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15H,3,8-9,13H2,1-2H3/t14-,15-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101835
PNG
(US9695163, 2)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(s1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(19-22-12-18(29-19)21(2,3)28)13-25(14)20(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15,28H,8-9,13H2,1-3H3/t14-,15-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101918
PNG
(US9695163, 31)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(16-12-29-20(24-16)21(2,3)27)11-25(13)19(26)15-7-10-28-17(15)18-22-8-4-9-23-18/h4,7-10,12-14,27H,5-6,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101920
PNG
(US9695163, 33)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2S/c1-15-9-10-16(19-14-30-22(26-19)23(2,3)29)13-27(15)21(28)18-8-5-4-7-17(18)20-24-11-6-12-25-20/h4-8,11-12,14-16,29H,9-10,13H2,1-3H3/t15-,16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101864
PNG
(US9695163, 15)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(17-22-16(11-28-17)19(2,3)26)8-23(12)18(25)14-9-27-10-15(14)24-20-6-7-21-24/h6-7,9-13,26H,4-5,8H2,1-3H3/t12-,13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101863
PNG
(US9695163, 14)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C20H24N6O2S/c1-13-8-9-14(18-23-17(11-29-18)20(2,3)28)10-25(13)19(27)15-6-4-5-7-16(15)26-22-12-21-24-26/h4-7,11-14,28H,8-10H2,1-3H3/t13-,14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101874
PNG
(US9695163, 18)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1nc(cs1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(19-24-16(12-29-19)21(2,3)27)11-25(13)20(26)15-7-10-28-17(15)18-22-8-4-9-23-18/h4,7-10,12-14,27H,5-6,11H2,1-3H3/t13-,14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101900
PNG
(US9695163, 26)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1CS(C)(=O)=O)c1nc(c(C)s1)C(C)(C)O
Show InChI InChI=1S/C22H30N2O4S2/c1-14-10-11-16(20-23-19(15(2)29-20)22(3,4)26)12-24(14)21(25)18-9-7-6-8-17(18)13-30(5,27)28/h6-9,14,16,26H,10-13H2,1-5H3/t14-,16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101858
PNG
(US9695163, 6)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@H](O)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2S/c1-12-6-7-13(18-26-15(11-31-18)17(29)20(21,22)23)10-27(12)19(30)14-4-2-3-5-16(14)28-24-8-9-25-28/h2-5,8-9,11-13,17,29H,6-7,10H2,1H3/t12-,13-,17+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101919
PNG
(US9695163, 32)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H24N4O2S2/c1-13-5-6-14(17-12-29-20(24-17)21(2,3)27)9-25(13)19(26)16-11-28-10-15(16)18-22-7-4-8-23-18/h4,7-8,10-14,27H,5-6,9H2,1-3H3/t13-,14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM50108615
PNG
(CHEMBL3597958 | US9695163, 35)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C19H23N5O2S2/c1-12-4-5-13(15-10-28-18(22-15)19(2,3)26)8-23(12)17(25)14-9-27-11-16(14)24-20-6-7-21-24/h6-7,9-13,26H,4-5,8H2,1-3H3/t12-,13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101646
PNG
(US9695163, 3)
Show SMILES C[C@@H]1CC[C@@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(s1)C(C)(C)O
Show InChI InChI=1S/C21H25N5O2S/c1-14-8-9-15(19-22-12-18(29-19)21(2,3)28)13-25(14)20(27)16-6-4-5-7-17(16)26-23-10-11-24-26/h4-7,10-12,14-15,28H,8-9,13H2,1-3H3/t14-,15+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101859
PNG
(US9695163, 8)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(cs1)[C@H](O)C(F)F
Show InChI InChI=1S/C20H21F2N5O2S/c1-12-6-7-13(19-25-15(11-30-19)17(28)18(21)22)10-26(12)20(29)14-4-2-3-5-16(14)27-23-8-9-24-27/h2-5,8-9,11-13,17-18,28H,6-7,10H2,1H3/t12-,13-,17+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101983
PNG
(US9695163, 34)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1CS(C)(=O)=O)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C21H28N2O4S2/c1-14-9-10-15(18-12-28-20(22-18)21(2,3)25)11-23(14)19(24)17-8-6-5-7-16(17)13-29(4,26)27/h5-8,12,14-15,25H,9-11,13H2,1-4H3/t14-,15-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM101910
PNG
(US9695163, 29)
Show SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1csc(n1)C(C)(C)O
Show InChI InChI=1S/C20H24N6O2S/c1-13-8-9-14(16-11-29-19(23-16)20(2,3)28)10-25(13)18(27)15-6-4-5-7-17(15)26-22-12-21-24-26/h4-7,11-14,28H,8-10H2,1-3H3/t13-,14-/m1/s1
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n/an/an/an/an/an/an/an/an/a



MERCK SHARP & DOHME CORP

US Patent


Assay Description
Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%