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Patent code US9695165

Compile Data Set for Download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102180
PNG
(US9695165, 12)
Show SMILES CCn1c2cc(ncc2cc(-c2cc(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C27H23ClFN3O4/c1-5-25(33)31-16-7-8-21(29)20(10-16)22-13-23-15(14-30-22)9-19(27(34)32(23)6-2)18-11-17(35-3)12-24(36-4)26(18)28/h5,7-14H,1,6H2,2-4H3,(H,31,33)
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US Patent
n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102218
PNG
(US9695165, 20)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-17-9-7-8-15(10-17)19-12-20-16(14-30-19)11-18(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103847
PNG
(US9695165, 30 | US9695165, 31)
Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103857
PNG
(US9695165, 40)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H24Cl2FN3O4/c1-6-24(35)33-16-7-8-19(31)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(29)22(37-4)12-23(38-5)27(25)30/h6-14H,1H2,2-5H3,(H,33,35)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103864
PNG
(US9695165, 47)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C29H25Cl2N3O5/c1-5-25(35)34-9-10-39-22-8-7-16(12-21(22)34)19-13-20-17(15-32-19)11-18(29(36)33(20)6-2)26-27(30)23(37-3)14-24(38-4)28(26)31/h5,7-8,11-15H,1,6,9-10H2,2-4H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103867
PNG
(US9695165, 50)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc2OCCN(C(=O)C=C)c2c1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H26Cl2N4O5/c1-5-24(35)33-9-10-39-21-8-7-16(11-20(21)33)18-12-19-17(14-31-18)15-34(28(36)32(19)6-2)27-25(29)22(37-3)13-23(38-4)26(27)30/h5,7-8,11-14H,1,6,9-10,15H2,2-4H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102213
PNG
(US9695165, 18)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCc2cc1F)C(=O)C=C
Show InChI InChI=1S/C27H20Cl2FN3O3/c1-4-23(34)33-8-7-14-10-18(30)17(11-20(14)33)27-31-13-16-9-15(5-6-19(16)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102219
PNG
(US9695165, 21)
Show SMILES CCn1c2cc(ncc2cc(-c2c(F)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C27H22ClF2N3O4/c1-5-23(34)32-15-7-8-18(29)16(10-15)19-11-20-14(13-31-19)9-17(27(35)33(20)6-2)24-25(28)21(36-3)12-22(37-4)26(24)30/h5,7-13H,1,6H2,2-4H3,(H,32,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102219
PNG
(US9695165, 21)
Show SMILES CCn1c2cc(ncc2cc(-c2c(F)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C27H22ClF2N3O4/c1-5-23(34)32-15-7-8-18(29)16(10-15)19-11-20-14(13-31-19)9-17(27(35)33(20)6-2)24-25(28)21(36-3)12-22(37-4)26(24)30/h5,7-13H,1,6H2,2-4H3,(H,32,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103852
PNG
(US9695165, 35)
Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C28H24Cl2N4O4/c1-5-22(35)34-10-9-15-7-8-16(12-19(15)34)26-31-14-17-11-18(28(36)33(6-2)27(17)32-26)23-24(29)20(37-3)13-21(38-4)25(23)30/h5,7-8,11-14H,1,6,9-10H2,2-4H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102167
PNG
(US9695165, 10)
Show SMILES COc1cc(OC)c(F)c(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H25F2N3O4/c1-6-26(34)32-17-7-8-22(29)21(10-17)23-13-24-16(14-31-23)9-20(28(35)33(24)15(2)3)19-11-18(36-4)12-25(37-5)27(19)30/h6-15H,1H2,2-5H3,(H,32,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102207
PNG
(US9695165, 17)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H24F3N3O4/c1-6-24(35)33-16-7-8-19(29)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-14H,1H2,2-5H3,(H,33,35)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102217
PNG
(US9695165, 19)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-18-10-8-7-9-16(18)19-12-20-15(14-30-19)11-17(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103849
PNG
(US9695165, 32)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cc(NC(=O)C=C)ccc1F)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H23Cl2FN4O4/c1-5-22(34)31-15-7-8-17(29)16(9-15)18-10-19-14(12-30-18)13-33(26(35)32(19)6-2)25-23(27)20(36-3)11-21(37-4)24(25)28/h5,7-12H,1,6,13H2,2-4H3,(H,31,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103854
PNG
(US9695165, 37)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C28H23Cl2N3O5/c1-5-24(34)33-8-9-38-21-7-6-15(11-20(21)33)18-12-19-16(14-31-18)10-17(28(35)32(19)2)25-26(29)22(36-3)13-23(37-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103858
PNG
(US9695165, 41)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)cc(F)c1F
Show InChI InChI=1S/C27H21Cl2F2N3O4/c1-5-22(35)33-14-8-15(26(31)17(30)9-14)18-10-19-13(12-32-18)7-16(27(36)34(19)6-2)23-24(28)20(37-3)11-21(38-4)25(23)29/h5,7-12H,1,6H2,2-4H3,(H,33,35)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103859
PNG
(US9695165, 42)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C2CCCC2)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C30H27Cl2N3O4/c1-4-26(36)34-21-12-8-7-11-19(21)22-14-23-17(16-33-22)13-20(30(37)35(23)18-9-5-6-10-18)27-28(31)24(38-2)15-25(39-3)29(27)32/h4,7-8,11-16,18H,1,5-6,9-10H2,2-3H3,(H,34,36)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102160
PNG
(US9695165, 9)
Show SMILES CCn1c2cc(ncc2cc(-c2cc(ccc2Cl)C(=O)NOC)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C27H23ClN4O4/c1-4-25(33)30-22-9-7-6-8-18(22)23-14-24-17(15-29-23)13-20(27(35)32(24)5-2)19-12-16(10-11-21(19)28)26(34)31-36-3/h4,6-15H,1,5H2,2-3H3,(H,30,33)(H,31,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102218
PNG
(US9695165, 20)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-17-9-7-8-15(10-17)19-12-20-16(14-30-19)11-18(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103860
PNG
(US9695165, 43)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C2CCCC2)c1=O)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C30H27Cl2N3O4/c1-4-26(36)34-19-9-7-8-17(12-19)22-14-23-18(16-33-22)13-21(30(37)35(23)20-10-5-6-11-20)27-28(31)24(38-2)15-25(39-3)29(27)32/h4,7-9,12-16,20H,1,5-6,10-11H2,2-3H3,(H,34,36)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102277
PNG
(US9695165, 25)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)
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US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103869
PNG
(US9695165, 52)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1
Show InChI InChI=1S/C31H29Cl2N3O5/c1-7-26(37)36-16-31(3,4)41-23-10-9-17(12-22(23)36)20-13-21-18(15-34-20)11-19(30(38)35(21)8-2)27-28(32)24(39-5)14-25(40-6)29(27)33/h7,9-15H,1,8,16H2,2-6H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102180
PNG
(US9695165, 12)
Show SMILES CCn1c2cc(ncc2cc(-c2cc(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C27H23ClFN3O4/c1-5-25(33)31-16-7-8-21(29)20(10-16)22-13-23-15(14-30-22)9-19(27(34)32(23)6-2)18-11-17(35-3)12-24(36-4)26(18)28/h5,7-14H,1,6H2,2-4H3,(H,31,33)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102207
PNG
(US9695165, 17)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H24F3N3O4/c1-6-24(35)33-16-7-8-19(29)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-14H,1H2,2-5H3,(H,33,35)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103862
PNG
(US9695165, 45)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C30H27Cl2N3O4/c1-5-26(36)35-11-7-8-17-9-10-18(13-22(17)35)21-14-23-19(16-33-21)12-20(30(37)34(23)6-2)27-28(31)24(38-3)15-25(39-4)29(27)32/h5,9-10,12-16H,1,6-8,11H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103870
PNG
(US9695165, 53)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc2N(C(C)COc2cc1F)C(=O)C=C
Show InChI InChI=1S/C30H26Cl2FN3O5/c1-6-26(37)36-15(3)14-41-23-10-19(33)17(9-22(23)36)20-11-21-16(13-34-20)8-18(30(38)35(21)7-2)27-28(31)24(39-4)12-25(40-5)29(27)32/h6,8-13,15H,1,7,14H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102229
PNG
(US9695165, 23)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C26H20Cl2FN3O4/c1-5-22(33)31-14-6-7-17(29)15(9-14)18-10-19-13(12-30-18)8-16(26(34)32(19)2)23-24(27)20(35-3)11-21(36-4)25(23)28/h5-12H,1H2,2-4H3,(H,31,33)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103607
PNG
(US9695165, 28)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1F)C(=O)C=C
Show InChI InChI=1S/C27H20Cl2FN3O4/c1-4-23(34)33-7-8-37-20-11-17(30)16(10-19(20)33)27-31-13-15-9-14(5-6-18(15)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103847
PNG
(US9695165, 30 | US9695165, 31)
Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103856
PNG
(US9695165, 39)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC
Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103857
PNG
(US9695165, 40)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H24Cl2FN3O4/c1-6-24(35)33-16-7-8-19(31)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(29)22(37-4)12-23(38-5)27(25)30/h6-14H,1H2,2-5H3,(H,33,35)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103856
PNG
(US9695165, 39)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC
Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103873
PNG
(US9695165, 56)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(cc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C31H28Cl2N4O5/c1-4-26(38)36-11-12-42-23-10-9-17(13-22(23)36)19-14-21-20(16-34-19)35-30(31(39)37(21)18-7-5-6-8-18)27-28(32)24(40-2)15-25(41-3)29(27)33/h4,9-10,13-16,18H,1,5-8,11-12H2,2-3H3
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102160
PNG
(US9695165, 9)
Show SMILES CCn1c2cc(ncc2cc(-c2cc(ccc2Cl)C(=O)NOC)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C27H23ClN4O4/c1-4-25(33)30-22-9-7-6-8-18(22)23-14-24-17(15-29-23)13-20(27(35)32(24)5-2)19-12-16(10-11-21(19)28)26(34)31-36-3/h4,6-15H,1,5H2,2-3H3,(H,30,33)(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103866
PNG
(US9695165, 49)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1cc(NC(=O)C=C)cc(OC(C)C)c1
Show InChI InChI=1S/C29H27Cl2N3O5/c1-7-25(35)33-18-8-16(9-19(11-18)39-15(2)3)21-12-22-17(14-32-21)10-20(29(36)34(22)4)26-27(30)23(37-5)13-24(38-6)28(26)31/h7-15H,1H2,2-6H3,(H,33,35)
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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103865
PNG
(US9695165, 48)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CC(C)(C)Oc2cc1F)C(=O)C=C
Show InChI InChI=1S/C29H24Cl2FN3O4/c1-6-24(36)35-14-29(2,3)39-21-11-18(32)17(10-20(21)35)28-33-13-16-9-15(7-8-19(16)34-28)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-13H,1,14H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103863
PNG
(US9695165, 46)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2n(C2CCCC2)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C29H26Cl2N4O4/c1-4-23(36)33-20-12-8-7-11-18(20)27-32-15-16-13-19(24-25(30)21(38-2)14-22(39-3)26(24)31)29(37)35(28(16)34-27)17-9-5-6-10-17/h4,7-8,11-15,17H,1,5-6,9-10H2,2-3H3,(H,33,36)
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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103852
PNG
(US9695165, 35)
Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C28H24Cl2N4O4/c1-5-22(35)34-10-9-15-7-8-16(12-19(15)34)26-31-14-17-11-18(28(36)33(6-2)27(17)32-26)23-24(29)20(37-3)13-21(38-4)25(23)30/h5,7-8,11-14H,1,6,9-10H2,2-4H3
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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102213
PNG
(US9695165, 18)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCc2cc1F)C(=O)C=C
Show InChI InChI=1S/C27H20Cl2FN3O3/c1-4-23(34)33-8-7-14-10-18(30)17(11-20(14)33)27-31-13-16-9-15(5-6-19(16)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3
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Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102204
PNG
(US9695165, 16)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C27H21Cl2N3O4/c1-4-23(33)32-9-10-36-20-8-6-16(12-19(20)32)27-30-14-17-11-15(5-7-18(17)31-27)24-25(28)21(34-2)13-22(35-3)26(24)29/h4-8,11-14H,1,9-10H2,2-3H3
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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102175
PNG
(US9695165, 11)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2CCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C27H21Cl2N3O3/c1-4-23(33)32-10-9-15-5-6-17(12-20(15)32)27-30-14-18-11-16(7-8-19(18)31-27)24-25(28)21(34-2)13-22(35-3)26(24)29/h4-8,11-14H,1,9-10H2,2-3H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103872
PNG
(US9695165, 55)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C31H28Cl2N4O5/c1-4-25(38)36-11-12-42-22-10-9-17(14-21(22)36)29-34-16-18-13-20(26-27(32)23(40-2)15-24(41-3)28(26)33)31(39)37(30(18)35-29)19-7-5-6-8-19/h4,9-10,13-16,19H,1,5-8,11-12H2,2-3H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103870
PNG
(US9695165, 53)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc2N(C(C)COc2cc1F)C(=O)C=C
Show InChI InChI=1S/C30H26Cl2FN3O5/c1-6-26(37)36-15(3)14-41-23-10-19(33)17(9-22(23)36)20-11-21-16(13-34-20)8-18(30(38)35(21)7-2)27-28(31)24(39-4)12-25(40-5)29(27)32/h6,8-13,15H,1,7,14H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103861
PNG
(US9695165, 44)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CC(C)(C)Oc2cc1C)C(=O)C=C
Show InChI InChI=1S/C30H27Cl2N3O4/c1-7-25(36)35-15-30(3,4)39-22-10-16(2)19(12-21(22)35)29-33-14-18-11-17(8-9-20(18)34-29)26-27(31)23(37-5)13-24(38-6)28(26)32/h7-14H,1,15H2,2-6H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103851
PNG
(US9695165, 34)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1
Show InChI InChI=1S/C29H25Cl2N3O4/c1-6-24(35)34-15-29(2,3)38-21-10-8-17(12-20(21)34)28-32-14-18-11-16(7-9-19(18)33-28)25-26(30)22(36-4)13-23(37-5)27(25)31/h6-14H,1,15H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103869
PNG
(US9695165, 52)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1
Show InChI InChI=1S/C31H29Cl2N3O5/c1-7-26(37)36-16-31(3,4)41-23-10-9-17(12-22(23)36)20-13-21-18(15-34-20)11-19(30(38)35(21)8-2)27-28(32)24(39-5)14-25(40-6)29(27)33/h7,9-15H,1,8,16H2,2-6H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102252
PNG
(US9695165, 24)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1C)C(=O)C=C
Show InChI InChI=1S/C28H23Cl2N3O4/c1-5-24(34)33-8-9-37-21-10-15(2)18(12-20(21)33)28-31-14-17-11-16(6-7-19(17)32-28)25-26(29)22(35-3)13-23(36-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103871
PNG
(US9695165, 54)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C32H29Cl2N3O5/c1-4-28(38)36-11-12-42-25-10-9-18(14-24(25)36)22-15-23-19(17-35-22)13-21(32(39)37(23)20-7-5-6-8-20)29-30(33)26(40-2)16-27(41-3)31(29)34/h4,9-10,13-17,20H,1,5-8,11-12H2,2-3H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102058
PNG
(US9695165, 4)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H26FN3O4/c1-6-27(33)31-19-7-8-24(29)23(12-19)25-14-26-18(15-30-25)11-22(28(34)32(26)16(2)3)17-9-20(35-4)13-21(10-17)36-5/h6-16H,1H2,2-5H3,(H,31,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102167
PNG
(US9695165, 10)
Show SMILES COc1cc(OC)c(F)c(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H25F2N3O4/c1-6-26(34)32-17-7-8-22(29)21(10-17)23-13-24-16(14-31-23)9-20(28(35)33(24)15(2)3)19-11-18(36-4)12-25(37-5)27(19)30/h6-15H,1H2,2-5H3,(H,32,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103503
PNG
(US9695165, 27)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1C
Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-17-9-8-15(3)18(11-17)20-12-21-16(14-31-20)10-19(28(35)33(21)7-2)25-26(29)22(36-4)13-23(37-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103867
PNG
(US9695165, 50)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc2OCCN(C(=O)C=C)c2c1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H26Cl2N4O5/c1-5-24(35)33-9-10-39-21-8-7-16(11-20(21)33)18-12-19-17(14-31-18)15-34(28(36)32(19)6-2)27-25(29)22(37-3)13-23(38-4)26(27)30/h5,7-8,11-14H,1,6,9-10,15H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102252
PNG
(US9695165, 24)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1C)C(=O)C=C
Show InChI InChI=1S/C28H23Cl2N3O4/c1-5-24(34)33-8-9-37-21-10-15(2)18(12-20(21)33)28-31-14-17-11-16(6-7-19(17)32-28)25-26(29)22(35-3)13-23(36-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103503
PNG
(US9695165, 27)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1C
Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-17-9-8-15(3)18(11-17)20-12-21-16(14-31-20)10-19(28(35)33(21)7-2)25-26(29)22(36-4)13-23(37-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103607
PNG
(US9695165, 28)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1F)C(=O)C=C
Show InChI InChI=1S/C27H20Cl2FN3O4/c1-4-23(34)33-7-8-37-20-11-17(30)16(10-19(20)33)27-31-13-15-9-14(5-6-18(15)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103610
PNG
(US9695165, 29)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cc(NC(=O)C=C)ccc1C)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C27H26Cl2N4O4/c1-6-23(34)31-17-9-8-15(3)18(10-17)19-11-20-16(13-30-19)14-33(27(35)32(20)7-2)26-24(28)21(36-4)12-22(37-5)25(26)29/h6,8-13H,1,7,14H2,2-5H3,(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103849
PNG
(US9695165, 32)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cc(NC(=O)C=C)ccc1F)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H23Cl2FN4O4/c1-5-22(34)31-15-7-8-17(29)16(9-15)18-10-19-14(12-30-18)13-33(26(35)32(19)6-2)25-23(27)20(36-3)11-21(37-4)24(25)28/h5,7-12H,1,6,13H2,2-4H3,(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM103864
PNG
(US9695165, 47)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C29H25Cl2N3O5/c1-5-25(35)34-9-10-39-22-8-7-16(12-21(22)34)19-13-20-17(15-32-19)11-18(29(36)33(20)6-2)26-27(30)23(37-3)14-24(38-4)28(26)31/h5,7-8,11-15H,1,6,9-10H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102226
PNG
(US9695165, 22)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H24Cl2N4O4/c1-5-22(33)30-17-9-7-8-15(10-17)18-11-19-16(13-29-18)14-32(26(34)31(19)6-2)25-23(27)20(35-3)12-21(36-4)24(25)28/h5,7-13H,1,6,14H2,2-4H3,(H,30,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103847
PNG
(US9695165, 30 | US9695165, 31)
Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103853
PNG
(US9695165, 36)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2cc1OC)-c1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C28H23Cl2N3O5/c1-5-24(34)33-8-9-38-20-7-6-15(11-19(20)33)28-31-14-16-10-17(21(35-2)12-18(16)32-28)25-26(29)22(36-3)13-23(37-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103855
PNG
(US9695165, 38)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(C(C)COc2cc1F)C(=O)C=C
Show InChI InChI=1S/C28H22Cl2FN3O4/c1-5-24(35)34-14(2)13-38-21-10-18(31)17(9-20(21)34)28-32-12-16-8-15(6-7-19(16)33-28)25-26(29)22(36-3)11-23(37-4)27(25)30/h5-12,14H,1,13H2,2-4H3
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103868
PNG
(US9695165, 51)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C30H30Cl2N4O4/c1-6-36-23-15-22(18-9-7-10-20(13-18)34-26(37)11-8-12-35(2)3)33-17-19(23)14-21(30(36)38)27-28(31)24(39-4)16-25(40-5)29(27)32/h7-11,13-17H,6,12H2,1-5H3,(H,34,37)/b11-8+
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102119
PNG
(US9695165, 7)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1c(F)cccc1NC(=O)C=C
Show InChI InChI=1S/C25H18Cl2FN3O3/c1-4-20(32)30-17-7-5-6-15(28)22(17)25-29-12-14-10-13(8-9-16(14)31-25)21-23(26)18(33-2)11-19(34-3)24(21)27/h4-12H,1H2,2-3H3,(H,30,32)
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102229
PNG
(US9695165, 23)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C26H20Cl2FN3O4/c1-5-22(33)31-14-6-7-17(29)15(9-14)18-10-19-13(12-30-18)8-16(26(34)32(19)2)23-24(27)20(35-3)11-21(36-4)25(23)28/h5-12H,1H2,2-4H3,(H,31,33)
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102217
PNG
(US9695165, 19)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-18-10-8-7-9-16(18)19-12-20-15(14-30-19)11-17(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102226
PNG
(US9695165, 22)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H24Cl2N4O4/c1-5-22(33)30-17-9-7-8-15(10-17)18-11-19-16(13-29-18)14-32(26(34)31(19)6-2)25-23(27)20(35-3)12-21(36-4)24(25)28/h5,7-13H,1,6,14H2,2-4H3,(H,30,33)
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102277
PNG
(US9695165, 25)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103502
PNG
(US9695165, 26)
Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1N(C)C(=O)C=C
Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32(3)20-11-9-8-10-17(20)19-13-21-16(15-31-19)12-18(28(35)33(21)7-2)25-26(29)22(36-4)14-23(37-5)27(25)30/h6,8-15H,1,7H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103851
PNG
(US9695165, 34)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1
Show InChI InChI=1S/C29H25Cl2N3O4/c1-6-24(35)34-15-29(2,3)38-21-10-8-17(12-20(21)34)28-32-14-18-11-16(7-9-19(18)33-28)25-26(30)22(36-4)13-23(37-5)27(25)31/h6-14H,1,15H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102196
PNG
(US9695165, 15)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2cc1OC)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C26H21Cl2N3O4/c1-5-22(32)30-17-9-7-6-8-15(17)26-29-13-14-10-16(19(33-2)11-18(14)31-26)23-24(27)20(34-3)12-21(35-4)25(23)28/h5-13H,1H2,2-4H3,(H,30,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM103850
PNG
(US9695165, 33)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2c(c1)N(CCC2(C)C)C(=O)C=C
Show InChI InChI=1S/C30H27Cl2N3O3/c1-6-25(36)35-12-11-30(2,3)20-9-7-18(14-22(20)35)29-33-16-19-13-17(8-10-21(19)34-29)26-27(31)23(37-4)15-24(38-5)28(26)32/h6-10,13-16H,1,11-12H2,2-5H3
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n/an/a 550n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102126
PNG
(US9695165, 8)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C25H18Cl2FN3O3/c1-4-21(32)30-15-6-7-17(28)16(10-15)25-29-12-14-9-13(5-8-18(14)31-25)22-23(26)19(33-2)11-20(34-3)24(22)27/h4-12H,1H2,2-3H3,(H,30,32)
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n/an/a 550n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102058
PNG
(US9695165, 4)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F
Show InChI InChI=1S/C28H26FN3O4/c1-6-27(33)31-19-7-8-24(29)23(12-19)25-14-26-18(15-30-25)11-22(28(34)32(26)16(2)3)17-9-20(35-4)13-21(10-17)36-5/h6-16H,1H2,2-5H3,(H,31,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102182
PNG
(US9695165, 13)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(OC)c2nc(ncc2c1)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C26H21Cl2N3O4/c1-5-21(32)30-17-8-6-7-14(10-17)26-29-13-16-9-15(11-20(35-4)25(16)31-26)22-23(27)18(33-2)12-19(34-3)24(22)28/h5-13H,1H2,2-4H3,(H,30,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Pancreatic endoplasmic reticulum kinase (PERK)


(Homo sapiens (Human))
BDBM102119
PNG
(US9695165, 7)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1c(F)cccc1NC(=O)C=C
Show InChI InChI=1S/C25H18Cl2FN3O3/c1-4-20(32)30-17-7-5-6-15(28)22(17)25-29-12-14-10-13(8-9-16(14)31-25)21-23(26)18(33-2)11-19(34-3)24(21)27/h4-12H,1H2,2-3H3,(H,30,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101996
PNG
(US9695165, 2)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C25H19Cl2N3O3/c1-4-21(31)29-18-8-6-5-7-16(18)25-28-13-15-11-14(9-10-17(15)30-25)22-23(26)19(32-2)12-20(33-3)24(22)27/h4-13H,1H2,2-3H3,(H,29,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101875
PNG
(US9695165, 1)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2cc(ncc2c1)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C26H20Cl2N2O3/c1-4-23(31)30-19-8-6-5-7-18(19)20-12-15-9-10-16(11-17(15)14-29-20)24-25(27)21(32-2)13-22(33-3)26(24)28/h4-14H,1H2,2-3H3,(H,30,31)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102062
PNG
(US9695165, 5)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc(NC(=O)C=C)ccc1C
Show InChI InChI=1S/C26H21Cl2N3O3/c1-5-22(32)30-17-8-6-14(2)18(11-17)26-29-13-16-10-15(7-9-19(16)31-26)23-24(27)20(33-3)12-21(34-4)25(23)28/h5-13H,1H2,2-4H3,(H,30,32)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102054
PNG
(US9695165, 3)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C25H19Cl2N3O3/c1-4-21(31)29-17-7-5-6-15(11-17)25-28-13-16-10-14(8-9-18(16)30-25)22-23(26)19(32-2)12-20(33-3)24(22)27/h4-13H,1H2,2-3H3,(H,29,31)
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Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102111
PNG
(US9695165, 6)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cccc(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C26H21Cl2N3O3/c1-5-22(32)31(2)18-8-6-7-16(12-18)26-29-14-17-11-15(9-10-19(17)30-26)23-24(27)20(33-3)13-21(34-4)25(23)28/h5-14H,1H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM102188
PNG
(US9695165, 14)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(OC)c2nc(ncc2c1)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C26H21Cl2N3O4/c1-5-21(32)30-17-9-7-6-8-16(17)26-29-13-15-10-14(11-20(35-4)25(15)31-26)22-23(27)18(33-2)12-19(34-3)24(22)28/h5-13H,1H2,2-4H3,(H,30,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


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Ligand-Target Pair
* indicates data uncertainty>20%