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Patent code US9695175

Compile Data Set for Download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106317
PNG
(US9695175, 22)
Show SMILES CCNC(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C23H17F4N7O/c1-3-28-21(35)14-5-4-12(9-16(14)24)18-6-7-20-29-30-22(34(20)32-18)23(26,27)15-8-13-11-33(2)31-19(13)10-17(15)25/h4-11H,3H2,1-2H3,(H,28,35)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


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More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107092
PNG
(US9695175, 43)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cc2CNC(=O)c2c(F)c1
Show InChI InChI=1S/C22H13F4N7O/c1-32-9-12-5-13(14(23)7-17(12)30-32)22(25,26)21-29-28-18-3-2-16(31-33(18)21)10-4-11-8-27-20(34)19(11)15(24)6-10/h2-7,9H,8H2,1H3,(H,27,34)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106309
PNG
(US9695175, 19)
Show SMILES CNC(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C22H15F4N7O/c1-27-20(34)13-4-3-11(8-15(13)23)17-5-6-19-28-29-21(33(19)31-17)22(25,26)14-7-12-10-32(2)30-18(12)9-16(14)24/h3-10H,1-2H3,(H,27,34)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106379
PNG
(US9695175, 28)
Show SMILES CNC(=O)c1c(F)cc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C22H14F5N7O/c1-28-20(35)19-14(24)6-10(7-15(19)25)16-3-4-18-29-30-21(34(18)32-16)22(26,27)12-5-11-9-33(2)31-17(11)8-13(12)23/h3-9H,1-2H3,(H,28,35)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106383
PNG
(US9695175, 29)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(NC(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C24H17F4N7O/c1-34-11-14-8-15(16(25)10-20(14)32-34)24(27,28)23-31-30-21-7-6-18(33-35(21)23)13-4-5-19(17(26)9-13)29-22(36)12-2-3-12/h4-12H,2-3H2,1H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107096
PNG
(US9695175, 44)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106237
PNG
(US9695175, 6)
Show SMILES CNC(=O)c1c(F)cc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C22H14F5N7O/c1-28-20(35)18-13(23)7-10(8-14(18)24)15-5-6-17-29-30-21(34(17)32-15)22(26,27)12-3-4-16-11(19(12)25)9-33(2)31-16/h3-9H,1-2H3,(H,28,35)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107371
PNG
(US9695175, 49)
Show SMILES Nc1nc2cc(F)c(Cc3nnc4ccc(nn34)-c3cnn(c3)C3CC3)cc2s1
Show InChI InChI=1S/C19H15FN8S/c20-13-7-15-16(29-19(21)23-15)5-10(13)6-18-25-24-17-4-3-14(26-28(17)18)11-8-22-27(9-11)12-1-2-12/h3-5,7-9,12H,1-2,6H2,(H2,21,23)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107317
PNG
(US9695175, 47)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ncc(cn12)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C20H15F3N8/c1-29-8-11-4-15(16(21)5-17(11)28-29)20(22,23)18-26-27-19-24-6-12(9-30(18)19)13-7-25-31(10-13)14-2-3-14/h4-10,14H,2-3H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106336
PNG
(US9695175, 23)
Show SMILES CC(C)NC(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C24H19F4N7O/c1-12(2)29-22(36)15-5-4-13(9-17(15)25)19-6-7-21-30-31-23(35(21)33-19)24(27,28)16-8-14-11-34(3)32-20(14)10-18(16)26/h4-12H,1-3H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106339
PNG
(US9695175, 24)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(C(=O)NC2CC2)c(F)c1
Show InChI InChI=1S/C24H17F4N7O/c1-34-11-13-8-16(18(26)10-20(13)32-34)24(27,28)23-31-30-21-7-6-19(33-35(21)23)12-2-5-15(17(25)9-12)22(36)29-14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106231
PNG
(US9695175, 5)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(C(=O)NC2CC2)c(F)c1
Show InChI InChI=1S/C24H17F4N7O/c1-34-11-15-19(32-34)7-6-16(21(15)26)24(27,28)23-31-30-20-9-8-18(33-35(20)23)12-2-5-14(17(25)10-12)22(36)29-13-3-4-13/h2,5-11,13H,3-4H2,1H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106190
PNG
(US9695175, 1)
Show SMILES CNC(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C22H15F4N7O/c1-27-20(34)12-4-3-11(9-15(12)23)16-7-8-18-28-29-21(33(18)31-16)22(25,26)14-5-6-17-13(19(14)24)10-32(2)30-17/h3-10H,1-2H3,(H,27,34)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106630
PNG
(US9695175, 37)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C18H13F3N8/c1-27-9-11(7-22-27)14-3-4-16-23-24-17(29(16)26-14)18(20,21)12-5-10-8-28(2)25-15(10)6-13(12)19/h3-9H,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106386
PNG
(US9695175, 30)
Show SMILES CNC(=O)c1cc(ccn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C21H15F3N8O/c1-25-19(33)17-8-11(5-6-26-17)15-3-4-18-27-28-20(32(18)30-15)21(23,24)13-7-12-10-31(2)29-16(12)9-14(13)22/h3-10H,1-2H3,(H,25,33)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106392
PNG
(US9695175, 34)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cncc(Cl)c1
Show InChI InChI=1S/C19H11ClF3N7/c1-29-9-11-5-13(14(21)6-16(11)27-29)19(22,23)18-26-25-17-3-2-15(28-30(17)18)10-4-12(20)8-24-7-10/h2-9H,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106571
PNG
(US9695175, 35)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(nc1)C#N
Show InChI InChI=1S/C20H11F3N8/c1-30-10-12-6-14(15(21)7-17(12)28-30)20(22,23)19-27-26-18-5-4-16(29-31(18)19)11-2-3-13(8-24)25-9-11/h2-7,9-10H,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106227
PNG
(US9695175, 3)
Show SMILES CCNC(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C23H17F4N7O/c1-3-28-21(35)13-5-4-12(10-16(13)24)17-8-9-19-29-30-22(34(19)32-17)23(26,27)15-6-7-18-14(20(15)25)11-33(2)31-18/h4-11H,3H2,1-2H3,(H,28,35)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106239
PNG
(US9695175, 7)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(NC(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C24H17F4N7O/c1-34-11-14-18(32-34)7-5-15(21(14)26)24(27,28)23-31-30-20-9-8-17(33-35(20)23)13-4-6-19(16(25)10-13)29-22(36)12-2-3-12/h4-12H,2-3H2,1H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106301
PNG
(US9695175, 17)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(c(F)c1)S(N)(=O)=O
Show InChI InChI=1S/C20H13F4N7O2S/c1-30-9-11-15(28-30)4-3-12(18(11)22)20(23,24)19-27-26-17-7-5-14(29-31(17)19)10-2-6-16(13(21)8-10)34(25,32)33/h2-9H,1H3,(H2,25,32,33)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107053
PNG
(US9695175, 39)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CCOC1
Show InChI InChI=1S/C21H17F3N8O/c1-30-9-12-6-15(16(22)7-18(12)28-30)21(23,24)20-27-26-19-3-2-17(29-32(19)20)13-8-25-31(10-13)14-4-5-33-11-14/h2-3,6-10,14H,4-5,11H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106387
PNG
(US9695175, 31)
Show SMILES CNC(=O)c1ccc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C21H15F3N8O/c1-25-19(33)16-4-3-11(9-26-16)15-5-6-18-27-28-20(32(18)30-15)21(23,24)13-7-12-10-31(2)29-17(12)8-14(13)22/h3-10H,1-2H3,(H,25,33)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


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More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106730
PNG
(US9695175, 38)
Show SMILES CC(C)n1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C20H17F3N8/c1-11(2)30-10-13(8-24-30)16-4-5-18-25-26-19(31(18)28-16)20(22,23)14-6-12-9-29(3)27-17(12)7-15(14)21/h4-11H,1-3H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


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More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106230
PNG
(US9695175, 4)
Show SMILES CC(C)NC(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C24H19F4N7O/c1-12(2)29-22(36)14-5-4-13(10-17(14)25)18-8-9-20-30-31-23(35(20)33-18)24(27,28)16-6-7-19-15(21(16)26)11-34(3)32-19/h4-12H,1-3H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106308
PNG
(US9695175, 18)
Show SMILES CNC(=O)c1ccc(c(F)c1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C22H15F4N7O/c1-27-20(34)11-3-4-13(15(23)8-11)17-5-6-19-28-29-21(33(19)31-17)22(25,26)14-7-12-10-32(2)30-18(12)9-16(14)24/h3-10H,1-2H3,(H,27,34)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106274
PNG
(US9695175, 14)
Show SMILES CC(C)n1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C20H17F3N8/c1-11(2)30-9-12(8-24-30)15-6-7-17-25-26-19(31(17)28-15)20(22,23)14-4-5-16-13(18(14)21)10-29(3)27-16/h4-11H,1-3H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106388
PNG
(US9695175, 32)
Show SMILES Cc1cncc(c1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C20H14F3N7/c1-11-5-12(9-24-8-11)16-3-4-18-25-26-19(30(18)28-16)20(22,23)14-6-13-10-29(2)27-17(13)7-15(14)21/h3-10H,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106581
PNG
(US9695175, 36)
Show SMILES Cc1cc(ccn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C20H14F3N7/c1-11-7-12(5-6-24-11)16-3-4-18-25-26-19(30(18)28-16)20(22,23)14-8-13-10-29(2)27-17(13)9-15(14)21/h3-10H,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106241
PNG
(US9695175, 9)
Show SMILES Cc1cncc(c1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C20H14F3N7/c1-11-7-12(9-24-8-11)15-5-6-17-25-26-19(30(17)28-15)20(22,23)14-3-4-16-13(18(14)21)10-29(2)27-16/h3-10H,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106354
PNG
(US9695175, 25)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(C(=O)N2CCCC2)c(F)c1
Show InChI InChI=1S/C25H19F4N7O/c1-34-13-15-10-17(19(27)12-21(15)32-34)25(28,29)24-31-30-22-7-6-20(33-36(22)24)14-4-5-16(18(26)11-14)23(37)35-8-2-3-9-35/h4-7,10-13H,2-3,8-9H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107090
PNG
(US9695175, 41)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(CC2COCO2)c1
Show InChI InChI=1S/C21H17F3N8O2/c1-30-7-12-4-15(16(22)5-18(12)28-30)21(23,24)20-27-26-19-3-2-17(29-32(19)20)13-6-25-31(8-13)9-14-10-33-11-34-14/h2-8,14H,9-11H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107091
PNG
(US9695175, 42)
Show SMILES CNS(=O)(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C21H15F4N7O2S/c1-26-35(33,34)18-5-3-11(8-15(18)23)16-4-6-19-27-28-20(32(19)30-16)21(24,25)13-7-12-10-31(2)29-17(12)9-14(13)22/h3-10,26H,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106313
PNG
(US9695175, 20)
Show SMILES CC(C)NC(=O)c1ccc(c(F)c1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C24H19F4N7O/c1-12(2)29-22(36)13-4-5-15(17(25)9-13)19-6-7-21-30-31-23(35(21)33-19)24(27,28)16-8-14-11-34(3)32-20(14)10-18(16)26/h4-12H,1-3H3,(H,29,36)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106363
PNG
(US9695175, 27)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C26H22F4N8O/c1-35-7-9-37(10-8-35)24(39)17-4-3-15(12-19(17)27)21-5-6-23-31-32-25(38(23)34-21)26(29,30)18-11-16-14-36(2)33-22(16)13-20(18)28/h3-6,11-14H,7-10H2,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106222
PNG
(US9695175, 2)
Show SMILES CN(C)C(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C23H17F4N7O/c1-32(2)21(35)13-5-4-12(10-16(13)24)17-8-9-19-28-29-22(34(19)31-17)23(26,27)15-6-7-18-14(20(15)25)11-33(3)30-18/h4-11H,1-3H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106240
PNG
(US9695175, 8)
Show SMILES CNC(=O)c1ccc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C21H15F3N8O/c1-25-19(33)16-5-3-11(9-26-16)14-7-8-17-27-28-20(32(17)30-14)21(23,24)13-4-6-15-12(18(13)22)10-31(2)29-15/h3-10H,1-2H3,(H,25,33)
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106266
PNG
(US9695175, 12)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cncc(c1)C#N
Show InChI InChI=1S/C20H11F3N8/c1-30-10-13-16(28-30)3-2-14(18(13)21)20(22,23)19-27-26-17-5-4-15(29-31(17)19)12-6-11(7-24)8-25-9-12/h2-6,8-10H,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107199
PNG
(US9695175, 46)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(cn12)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C21H16F3N7/c1-29-9-13-6-16(17(22)7-18(13)28-29)21(23,24)20-27-26-19-5-2-12(10-30(19)20)14-8-25-31(11-14)15-3-4-15/h2,5-11,15H,3-4H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106315
PNG
(US9695175, 21)
Show SMILES CN(C)C(=O)c1ccc(cc1F)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C23H17F4N7O/c1-32(2)21(35)14-5-4-12(9-16(14)24)18-6-7-20-28-29-22(34(20)31-18)23(26,27)15-8-13-11-33(3)30-19(13)10-17(15)25/h4-11H,1-3H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106273
PNG
(US9695175, 13)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(nc1)C#N
Show InChI InChI=1S/C20H11F3N8/c1-30-10-13-16(28-30)5-4-14(18(13)21)20(22,23)19-27-26-17-7-6-15(29-31(17)19)11-2-3-12(8-24)25-9-11/h2-7,9-10H,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106264
PNG
(US9695175, 11)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cncc(Cl)c1
Show InChI InChI=1S/C19H11ClF3N7/c1-29-9-12-15(27-29)3-2-13(17(12)21)19(22,23)18-26-25-16-5-4-14(28-30(16)18)10-6-11(20)8-24-7-10/h2-9H,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107088
PNG
(US9695175, 40)
Show SMILES COCCn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Show InChI InChI=1S/C20H17F3N8O/c1-29-10-12-7-14(15(21)8-17(12)27-29)20(22,23)19-26-25-18-4-3-16(28-31(18)19)13-9-24-30(11-13)5-6-32-2/h3-4,7-11H,5-6H2,1-2H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106389
PNG
(US9695175, 33)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cncc(F)c1
Show InChI InChI=1S/C19H11F4N7/c1-29-9-11-5-13(14(21)6-16(11)27-29)19(22,23)18-26-25-17-3-2-15(28-30(17)18)10-4-12(20)8-24-7-10/h2-9H,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106294
PNG
(US9695175, 16)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(CC2COCO2)c1
Show InChI InChI=1S/C21H17F3N8O2/c1-30-9-14-17(28-30)3-2-15(19(14)22)21(23,24)20-27-26-18-5-4-16(29-32(18)20)12-6-25-31(7-12)8-13-10-33-11-34-13/h2-7,9,13H,8,10-11H2,1H3
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n/an/a 247n/an/an/an/an/an/a



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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


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More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106247
PNG
(US9695175, 10)
Show SMILES Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cncc(F)c1
Show InChI InChI=1S/C19H11F4N7/c1-29-9-12-15(27-29)3-2-13(17(12)21)19(22,23)18-26-25-16-5-4-14(28-30(16)18)10-6-11(20)8-24-7-10/h2-9H,1H3
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n/an/a 261n/an/an/an/an/an/a



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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107113
PNG
(US9695175, 45)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)C1(Cl)NN=C2C=CC(=CN12)c1cnn(c1)C1CC1
Show InChI InChI=1S/C21H17ClF3N7/c1-30-9-13-6-16(17(23)7-18(13)28-30)20(24,25)21(22)29-27-19-5-2-12(10-31(19)21)14-8-26-32(11-14)15-3-4-15/h2,5-11,15,29H,3-4H2,1H3
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n/an/a 274n/an/an/an/an/an/a



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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106360
PNG
(US9695175, 26)
Show SMILES Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1ccc(C(=O)N2CCOCC2)c(F)c1
Show InChI InChI=1S/C25H19F4N7O2/c1-34-13-15-10-17(19(27)12-21(15)32-34)25(28,29)24-31-30-22-5-4-20(33-36(22)24)14-2-3-16(18(26)11-14)23(37)35-6-8-38-9-7-35/h2-5,10-13H,6-9H2,1H3
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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM106277
PNG
(US9695175, 15)
Show SMILES COCCn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2nn(C)cc2c1F
Show InChI InChI=1S/C20H17F3N8O/c1-29-11-13-16(27-29)4-3-14(18(13)21)20(22,23)19-26-25-17-6-5-15(28-31(17)19)12-9-24-30(10-12)7-8-32-2/h3-6,9-11H,7-8H2,1-2H3
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n/an/a 380n/an/an/an/an/an/a



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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107634
PNG
(US9695175, 52)
Show SMILES Nc1nc2ccc(cc2[nH]1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C19H15F2N9/c20-19(21,11-1-4-14-15(7-11)25-18(22)24-14)17-27-26-16-6-5-13(28-30(16)17)10-8-23-29(9-10)12-2-3-12/h1,4-9,12H,2-3H2,(H3,22,24,25)
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n/an/a 568n/an/an/an/an/an/a



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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107497
PNG
(US9695175, 50)
Show SMILES Fc1cc2n[nH]cc2cc1C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C19H13F3N8/c20-14-6-16-10(7-23-25-16)5-13(14)19(21,22)18-27-26-17-4-3-15(28-30(17)18)11-8-24-29(9-11)12-1-2-12/h3-9,12H,1-2H2,(H,23,25)
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n/an/a 1.44E+3n/an/an/an/an/an/a



CB THERAPEUTICS INC.

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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (MET)


(Homo sapiens (Human))
BDBM107591
PNG
(US9695175, 51)
Show SMILES Fc1cc2nn(cc2cc1C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CC1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C26H25F3N10O2/c27-20-12-22-16(14-38(34-22)25(40)30-5-6-36-7-9-41-10-8-36)11-19(20)26(28,29)24-33-32-23-4-3-21(35-39(23)24)17-13-31-37(15-17)18-1-2-18/h3-4,11-15,18H,1-2,5-10H2,(H,30,40)
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n/an/a 4.13E+3n/an/an/an/an/an/a



CB THERAPEUTICS INC.

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Assay Description
Optiplate-384 well plate (PerKinElmer), kinase buffer (50 mM Hepes pH7.5, 25 mM NaCl, 2 mM DTT, 0.01% Tween 20, 5 mM Mg2+, 0.5 mM Mn2+), c-Met kinase...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%