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Patent code US9695180

Compile Data Set for Download or QSAR
Found 119 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Human)
BDBM111161
PNG
(US9695180, 13)
Show SMILES Cc1ccc(cc1)-c1c(nc(SC[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5S/c1-17-2-6-21(7-3-17)23-22(20-8-4-18(14-26)5-9-20)29-25(24-28-12-13-30(23)24)31-16-19-10-11-27-15-19/h2-9,12-13,19,27H,10-11,15-16H2,1H3/t19-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111189
PNG
(US9695180, 41)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(CO)cn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5O2/c1-17-2-6-21(7-3-17)24-23(20-8-4-18(12-27)5-9-20)30-26(33-16-19-10-11-28-13-19)25-29-22(15-32)14-31(24)25/h2-9,14,19,28,32H,10-11,13,15-16H2,1H3/t19-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111213
PNG
(US9695180, 65)
Show SMILES Cn1ncc2cc(ccc12)-c1c(nc(OC[C@@H]2CCCN(CCO)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H29N7O2/c1-34-25-9-8-23(15-24(25)17-32-34)27-26(22-6-4-20(16-30)5-7-22)33-29(28-31-10-12-36(27)28)38-19-21-3-2-11-35(18-21)13-14-37/h4-10,12,15,17,21,37H,2-3,11,13-14,18-19H2,1H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111399
PNG
(US9695180, 68)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)nc(N)c3c2)n2ccnc12
Show InChI InChI=1S/C28H29N9/c1-34(2)21-10-13-36(14-11-21)28-27-31-12-15-37(27)25(24(32-28)19-6-4-18(17-29)5-7-19)20-8-9-23-22(16-20)26(30)33-35(23)3/h4-9,12,15-16,21H,10-11,13-14H2,1-3H3,(H2,30,33)
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111801
PNG
(US9695180, 79)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc4C(O)CCc4c(F)c3)n3ccnc23)C1
Show InChI InChI=1S/C29H28FN5O2/c1-34-11-2-3-19(16-34)17-37-29-28-32-10-12-35(28)27(26(33-29)20-6-4-18(15-31)5-7-20)21-13-23-22(24(30)14-21)8-9-25(23)36/h4-7,10,12-14,19,25,36H,2-3,8-9,11,16-17H2,1H3/t19-,25?/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112391
PNG
(US9695180, 87)
Show SMILES CC(O)c1cc(ccc1C)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H31N5O2/c1-19-6-9-24(15-25(19)20(2)35)27-26(23-10-7-21(16-30)8-11-23)32-29(28-31-12-14-34(27)28)36-18-22-5-4-13-33(3)17-22/h6-12,14-15,20,22,35H,4-5,13,17-18H2,1-3H3/t20?,22-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112400
PNG
(US9695180, 91)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)c(CC#N)c3)n3ccnc23)C1
Show InChI InChI=1S/C29H28N6O/c1-20-5-8-25(16-24(20)11-12-30)27-26(23-9-6-21(17-31)7-10-23)33-29(28-32-13-15-35(27)28)36-19-22-4-3-14-34(2)18-22/h5-10,13,15-16,22H,3-4,11,14,18-19H2,1-2H3/t22-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112490
PNG
(US9695180, 109)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCN(C)C(=O)C2)n2ccnc12
Show InChI InChI=1S/C30H33N9O/c1-35(2)24-10-13-37(14-11-24)30-29-32-12-15-39(29)28(27(34-30)22-6-4-21(18-31)5-7-22)23-8-9-25(33-19-23)38-17-16-36(3)26(40)20-38/h4-9,12,15,19,24H,10-11,13-14,16-17,20H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112492
PNG
(US9695180, 111)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3N(C)C(=O)Cc3c2)n2ccnc12
Show InChI InChI=1S/C28H28N8O/c1-33(2)22-8-11-35(12-9-22)28-27-30-10-13-36(27)25(24(32-28)19-6-4-18(16-29)5-7-19)21-14-20-15-23(37)34(3)26(20)31-17-21/h4-7,10,13-14,17,22H,8-9,11-12,15H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112649
PNG
(US9695180, 118)
Show SMILES COc1ncc(cc1O)-c1c(nc(N2CCC(CC2)N(C)C)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27N7O2/c1-31(2)20-8-11-32(12-9-20)25-24-28-10-13-33(24)23(19-14-21(34)26(35-3)29-16-19)22(30-25)18-6-4-17(15-27)5-7-18/h4-7,10,13-14,16,20,34H,8-9,11-12H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111153
PNG
(US9695180, 5)
Show SMILES CN(C)[C@@H]1CCN(Cc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ccnc23)C1
Show InChI InChI=1S/C27H28N6/c1-19-4-8-22(9-5-19)26-25(21-10-6-20(16-28)7-11-21)30-24(27-29-13-15-33(26)27)18-32-14-12-23(17-32)31(2)3/h4-11,13,15,23H,12,14,17-18H2,1-3H3/t23-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111162
PNG
(US9695180, 14)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C27H28N6/c1-19-4-8-22(9-5-19)25-24(21-10-6-20(18-28)7-11-21)30-27(26-29-14-17-33(25)26)32-15-12-23(13-16-32)31(2)3/h4-11,14,17,23H,12-13,15-16H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111190
PNG
(US9695180, 42)
Show SMILES CN(C)Cc1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H30N6O/c1-19-4-8-23(9-5-19)26-25(22-10-6-20(14-29)7-11-22)32-28(35-18-21-12-13-30-15-21)27-31-24(16-33(2)3)17-34(26)27/h4-11,17,21,30H,12-13,15-16,18H2,1-3H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111200
PNG
(US9695180, 52)
Show SMILES CN(CC1CCCO1)c1ccc(cn1)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C31H35N7O2/c1-36-14-3-5-23(19-36)21-40-31-30-33-13-15-38(30)29(28(35-31)24-9-7-22(17-32)8-10-24)25-11-12-27(34-18-25)37(2)20-26-6-4-16-39-26/h7-13,15,18,23,26H,3-6,14,16,19-21H2,1-2H3/t23-,26?/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111207
PNG
(US9695180, 59)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)c(=O)oc3c2)n2ccnc12
Show InChI InChI=1S/C28H27N7O2/c1-32(2)21-10-13-34(14-11-21)27-26-30-12-15-35(26)25(24(31-27)19-6-4-18(17-29)5-7-19)20-8-9-22-23(16-20)37-28(36)33(22)3/h4-9,12,15-16,21H,10-11,13-14H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111798
PNG
(US9695180, 76)
Show SMILES COC(=O)N(C)c1cc(ccc1C)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H32N6O3/c1-20-7-10-24(16-25(20)35(3)30(37)38-4)27-26(23-11-8-21(17-31)9-12-23)33-29(28-32-13-15-36(27)28)39-19-22-6-5-14-34(2)18-22/h7-13,15-16,22H,5-6,14,18-19H2,1-4H3/t22-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112453
PNG
(US9695180, 102)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3N(C)C(=O)CCc3c2)n2ccnc12
Show InChI InChI=1S/C30H31N7O/c1-34(2)24-12-15-36(16-13-24)30-29-32-14-17-37(29)28(27(33-30)21-6-4-20(19-31)5-7-21)23-8-10-25-22(18-23)9-11-26(38)35(25)3/h4-8,10,14,17-18,24H,9,11-13,15-16H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112494
PNG
(US9695180, 113)
Show SMILES C[C@@H](O)c1nc2cc(ccc2n1C)-c1c(nc(N2CCC(CC2)N(C)C)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H32N8O/c1-19(39)28-33-24-17-22(9-10-25(24)36(28)4)27-26(21-7-5-20(18-31)6-8-21)34-30(29-32-13-16-38(27)29)37-14-11-23(12-15-37)35(2)3/h5-10,13,16-17,19,23,39H,11-12,14-15H2,1-4H3/t19-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111157
PNG
(US9695180, 9)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5O/c1-18-4-8-22(9-5-18)24-23(21-10-6-19(15-27)7-11-21)30-26(25-29-13-14-31(24)25)32-17-20-3-2-12-28-16-20/h4-11,13-14,20,28H,2-3,12,16-17H2,1H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111166
PNG
(US9695180, 18)
Show SMILES CN1CCCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C26H26N6/c1-19-4-8-22(9-5-19)24-23(21-10-6-20(18-27)7-11-21)29-26(25-28-12-15-32(24)25)31-14-3-13-30(2)16-17-31/h4-12,15H,3,13-14,16-17H2,1-2H3
PDB

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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111168
PNG
(US9695180, 20)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC3(CNC3)CC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H26N6/c1-19-2-6-22(7-3-19)24-23(21-8-4-20(16-28)5-9-21)31-26(25-30-12-15-33(24)25)32-13-10-27(11-14-32)17-29-18-27/h2-9,12,15,29H,10-11,13-14,17-18H2,1H3
PDB

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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111178
PNG
(US9695180, 30)
Show SMILES COc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5O2/c1-31-21-8-6-20(7-9-21)23-22(19-4-2-17(14-26)3-5-19)29-25(24-28-12-13-30(23)24)32-16-18-10-11-27-15-18/h2-9,12-13,18,27H,10-11,15-16H2,1H3/t18-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111184
PNG
(US9695180, 36)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(CC#N)cn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H24N6O/c1-18-2-6-22(7-3-18)25-24(21-8-4-19(14-29)5-9-21)32-27(34-17-20-11-13-30-15-20)26-31-23(10-12-28)16-33(25)26/h2-9,16,20,30H,10-11,13,15,17H2,1H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111185
PNG
(US9695180, 37)
Show SMILES CNC(=O)c1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H26N6O2/c1-17-3-7-21(8-4-17)24-23(20-9-5-18(13-28)6-10-20)32-27(35-16-19-11-12-30-14-19)25-31-22(15-33(24)25)26(34)29-2/h3-10,15,19,30H,11-12,14,16H2,1-2H3,(H,29,34)/t19-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111186
PNG
(US9695180, 38)
Show SMILES CN(C)C(=O)c1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H28N6O2/c1-18-4-8-22(9-5-18)25-24(21-10-6-19(14-29)7-11-21)32-27(36-17-20-12-13-30-15-20)26-31-23(16-34(25)26)28(35)33(2)3/h4-11,16,20,30H,12-13,15,17H2,1-3H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111191
PNG
(US9695180, 43)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(CN3CCC3)cn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H30N6O/c1-20-3-7-24(8-4-20)27-26(23-9-5-21(15-30)6-10-23)33-29(36-19-22-11-12-31-16-22)28-32-25(18-35(27)28)17-34-13-2-14-34/h3-10,18,22,31H,2,11-14,16-17,19H2,1H3/t22-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111206
PNG
(US9695180, 58)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3n(C)ncc3c2)n2ccnc12
Show InChI InChI=1S/C27H27N9/c1-33(2)22-8-11-35(12-9-22)27-26-29-10-13-36(26)24(20-14-21-17-31-34(3)25(21)30-16-20)23(32-27)19-6-4-18(15-28)5-7-19/h4-7,10,13-14,16-17,22H,8-9,11-12H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112416
PNG
(US9695180, 96)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)c(CO)c2)n2ccnc12
Show InChI InChI=1S/C28H30N6O/c1-19-4-7-22(16-23(19)18-35)26-25(21-8-5-20(17-29)6-9-21)31-28(27-30-12-15-34(26)27)33-13-10-24(11-14-33)32(2)3/h4-9,12,15-16,24,35H,10-11,13-14,18H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112486
PNG
(US9695180, 106)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)cnc3c2)n2ccnc12
Show InChI InChI=1S/C28H28N8/c1-33(2)22-10-13-35(14-11-22)28-27-30-12-15-36(27)26(21-8-9-24-23(16-21)31-18-34(24)3)25(32-28)20-6-4-19(17-29)5-7-20/h4-9,12,15-16,18,22H,10-11,13-14H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111159
PNG
(US9695180, 11)
Show SMILES CN1CC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ccnc23)C1
Show InChI InChI=1S/C26H25N5O/c1-18-3-7-22(8-4-18)24-23(21-9-5-19(15-27)6-10-21)29-26(25-28-12-14-31(24)25)32-17-20-11-13-30(2)16-20/h3-10,12,14,20H,11,13,16-17H2,1-2H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111160
PNG
(US9695180, 12)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ccnc23)C1
Show InChI InChI=1S/C27H27N5O/c1-19-5-9-23(10-6-19)25-24(22-11-7-20(16-28)8-12-22)30-27(26-29-13-15-32(25)26)33-18-21-4-3-14-31(2)17-21/h5-13,15,21H,3-4,14,17-18H2,1-2H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111187
PNG
(US9695180, 39)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(cn12)C(=O)NC1CC1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H28N6O2/c1-18-2-6-22(7-3-18)26-25(21-8-4-19(14-30)5-9-21)34-29(37-17-20-12-13-31-15-20)27-33-24(16-35(26)27)28(36)32-23-10-11-23/h2-9,16,20,23,31H,10-13,15,17H2,1H3,(H,32,36)/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111188
PNG
(US9695180, 40)
Show SMILES CN1CC(C1)NC(=O)c1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H31N7O2/c1-19-3-7-23(8-4-19)27-26(22-9-5-20(13-31)6-10-22)35-30(39-18-21-11-12-32-14-21)28-34-25(17-37(27)28)29(38)33-24-15-36(2)16-24/h3-10,17,21,24,32H,11-12,14-16,18H2,1-2H3,(H,33,38)/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111210
PNG
(US9695180, 62)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cc3oc(=O)n(C)c3cc2F)n2ccnc12
Show InChI InChI=1S/C28H26FN7O2/c1-33(2)19-8-11-35(12-9-19)27-26-31-10-13-36(26)25(24(32-27)18-6-4-17(16-30)5-7-18)20-14-23-22(15-21(20)29)34(3)28(37)38-23/h4-7,10,13-15,19H,8-9,11-12H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111397
PNG
(US9695180, 66)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3n(C)c(=O)oc3c2)n2ccnc12
Show InChI InChI=1S/C27H26N8O2/c1-32(2)20-8-11-34(12-9-20)26-25-29-10-13-35(25)23(22(31-26)18-6-4-17(15-28)5-7-18)19-14-21-24(30-16-19)33(3)27(36)37-21/h4-7,10,13-14,16,20H,8-9,11-12H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111398
PNG
(US9695180, 67)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCOC2=O)n2ccnc12
Show InChI InChI=1S/C28H28N8O2/c1-33(2)22-9-12-34(13-10-22)27-26-30-11-14-36(26)25(24(32-27)20-5-3-19(17-29)4-6-20)21-7-8-23(31-18-21)35-15-16-38-28(35)37/h3-8,11,14,18,22H,9-10,12-13,15-16H2,1-2H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111458
PNG
(US9695180, 69)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)c(c3)C#N)n3ccnc23)C1
Show InChI InChI=1S/C28H26N6O/c1-19-5-8-23(14-24(19)16-30)26-25(22-9-6-20(15-29)7-10-22)32-28(27-31-11-13-34(26)27)35-18-21-4-3-12-33(2)17-21/h5-11,13-14,21H,3-4,12,17-18H2,1-2H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111793
PNG
(US9695180, 73)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4CCC(O)c4c3)n3ccnc23)C1
Show InChI InChI=1S/C29H29N5O2/c1-33-13-2-3-20(17-33)18-36-29-28-31-12-14-34(28)27(23-9-8-21-10-11-25(35)24(21)15-23)26(32-29)22-6-4-19(16-30)5-7-22/h4-9,12,14-15,20,25,35H,2-3,10-11,13,17-18H2,1H3/t20-,25?/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111803
PNG
(US9695180, 81)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc(C)c(CO)c(F)c3)n3ccnc23)C1
Show InChI InChI=1S/C28H28FN5O2/c1-18-12-22(13-24(29)23(18)16-35)26-25(21-7-5-19(14-30)6-8-21)32-28(27-31-9-11-34(26)27)36-17-20-4-3-10-33(2)15-20/h5-9,11-13,20,35H,3-4,10,15-17H2,1-2H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112407
PNG
(US9695180, 94)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc(C)c(O)c2)n2ccnc12
Show InChI InChI=1S/C26H27N7O/c1-17-22(34)14-20(16-29-17)24-23(19-6-4-18(15-27)5-7-19)30-26(25-28-10-13-33(24)25)32-11-8-21(9-12-32)31(2)3/h4-7,10,13-14,16,21,34H,8-9,11-12H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112417
PNG
(US9695180, 97)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cc(C)c(CO)c(F)c2)n2ccnc12
Show InChI InChI=1S/C28H29FN6O/c1-18-14-21(15-24(29)23(18)17-36)26-25(20-6-4-19(16-30)5-7-20)32-28(27-31-10-13-35(26)27)34-11-8-22(9-12-34)33(2)3/h4-7,10,13-15,22,36H,8-9,11-12,17H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112422
PNG
(US9695180, 98)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3N(C)C(=O)Cc3c2)n2ccnc12
Show InChI InChI=1S/C29H29N7O/c1-33(2)23-10-13-35(14-11-23)29-28-31-12-15-36(28)27(26(32-29)20-6-4-19(18-30)5-7-20)21-8-9-24-22(16-21)17-25(37)34(24)3/h4-9,12,15-16,23H,10-11,13-14,17H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112480
PNG
(US9695180, 103)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3n(C)c(CO)cc3c2)n2ccnc12
Show InChI InChI=1S/C29H30N8O/c1-34(2)23-8-11-36(12-9-23)29-28-31-10-13-37(28)26(25(33-29)20-6-4-19(16-30)5-7-20)22-14-21-15-24(18-38)35(3)27(21)32-17-22/h4-7,10,13-15,17,23,38H,8-9,11-12,18H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112485
PNG
(US9695180, 105)
Show SMILES CCn1c2ncc(cc2oc1=O)-c1c(nc(N2CCC(CC2)N(C)C)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H28N8O2/c1-4-35-25-22(38-28(35)37)15-20(17-31-25)24-23(19-7-5-18(16-29)6-8-19)32-27(26-30-11-14-36(24)26)34-12-9-21(10-13-34)33(2)3/h5-8,11,14-15,17,21H,4,9-10,12-13H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112487
PNG
(US9695180, 107)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3N(C)C(=O)COc3c2)n2ccnc12
Show InChI InChI=1S/C28H28N8O2/c1-33(2)21-8-11-35(12-9-21)28-27-30-10-13-36(27)25(24(32-28)19-6-4-18(15-29)5-7-19)20-14-22-26(31-16-20)34(3)23(37)17-38-22/h4-7,10,13-14,16,21H,8-9,11-12,17H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111127
PNG
(US9695180, 2)
Show SMILES Cc1ccc(cc1)-c1c(nc(CCC2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5/c1-18-2-7-22(8-3-18)25-24(21-9-4-19(16-27)5-10-21)30-23(26-29-14-15-31(25)26)11-6-20-12-13-28-17-20/h2-5,7-10,14-15,20,28H,6,11-13,17H2,1H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111167
PNG
(US9695180, 19)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC3(CCNC3)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H26N6/c1-19-2-6-22(7-3-19)24-23(21-8-4-20(16-28)5-9-21)31-26(25-30-13-15-33(24)25)32-14-11-27(18-32)10-12-29-17-27/h2-9,13,15,29H,10-12,14,17-18H2,1H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111181
PNG
(US9695180, 33)
Show SMILES Cc1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5O/c1-17-3-7-22(8-4-17)24-23(21-9-5-19(13-27)6-10-21)30-26(25-29-18(2)15-31(24)25)32-16-20-11-12-28-14-20/h3-10,15,20,28H,11-12,14,16H2,1-2H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111205
PNG
(US9695180, 57)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCCC2=O)n2ccnc12
Show InChI InChI=1S/C29H30N8O/c1-34(2)23-11-15-35(16-12-23)29-28-31-13-17-37(28)27(26(33-29)21-7-5-20(18-30)6-8-21)22-9-10-24(32-19-22)36-14-3-4-25(36)38/h5-10,13,17,19,23H,3-4,11-12,14-16H2,1-2H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111786
PNG
(US9695180, 72)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(CO)c(C)c3)n3ccnc23)C1
Show InChI InChI=1S/C28H29N5O2/c1-19-14-23(9-10-24(19)17-34)26-25(22-7-5-20(15-29)6-8-22)31-28(27-30-11-13-33(26)27)35-18-21-4-3-12-32(2)16-21/h5-11,13-14,21,34H,3-4,12,16-18H2,1-2H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111802
PNG
(US9695180, 80)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4C(O)CCc4c3)n3ccnc23)C1
Show InChI InChI=1S/C29H29N5O2/c1-33-13-2-3-20(17-33)18-36-29-28-31-12-14-34(28)27(23-8-10-24-22(15-23)9-11-25(24)35)26(32-29)21-6-4-19(16-30)5-7-21/h4-8,10,12,14-15,20,25,35H,2-3,9,11,13,17-18H2,1H3/t20-,25?/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112389
PNG
(US9695180, 85)
Show SMILES COC(=O)N(C)Cc1ccc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H31FN6O3/c1-35-13-4-5-21(17-35)19-40-29-28-33-12-14-37(28)27(26(34-29)22-8-6-20(16-32)7-9-22)23-10-11-24(25(31)15-23)18-36(2)30(38)39-3/h6-12,14-15,21H,4-5,13,17-19H2,1-3H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112412
PNG
(US9695180, 95)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3CCC(O)c3c2)n2ccnc12
Show InChI InChI=1S/C29H30N6O/c1-33(2)23-11-14-34(15-12-23)29-28-31-13-16-35(28)27(22-8-7-20-9-10-25(36)24(20)17-22)26(32-29)21-5-3-19(18-30)4-6-21/h3-8,13,16-17,23,25,36H,9-12,14-15H2,1-2H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112650
PNG
(US9695180, 119)
Show SMILES COc1ncc(cc1O)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N6O3/c1-31-10-3-4-18(15-31)16-35-26-24-28-9-11-32(24)23(20-12-21(33)25(34-2)29-14-20)22(30-26)19-7-5-17(13-27)6-8-19/h5-9,11-12,14,18,33H,3-4,10,15-16H2,1-2H3/t18-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111152
PNG
(US9695180, 4)
Show SMILES CN(C)[C@H]1CCN(Cc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ccnc23)C1
Show InChI InChI=1S/C27H28N6/c1-19-4-8-22(9-5-19)26-25(21-10-6-20(16-28)7-11-21)30-24(27-29-13-15-33(26)27)18-32-14-12-23(17-32)31(2)3/h4-11,13,15,23H,12,14,17-18H2,1-3H3/t23-/m0/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111155
PNG
(US9695180, 7)
Show SMILES CN1CCC(C1)Oc1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C25H23N5O/c1-17-3-7-20(8-4-17)23-22(19-9-5-18(15-26)6-10-19)28-25(24-27-12-14-30(23)24)31-21-11-13-29(2)16-21/h3-10,12,14,21H,11,13,16H2,1-2H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111177
PNG
(US9695180, 29)
Show SMILES N#Cc1ccc(cc1)-c1nc(OC[C@@H]2CCNC2)c2nccn2c1-c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C29H30N6O/c30-18-21-4-6-23(7-5-21)26-27(24-8-10-25(11-9-24)34-15-2-1-3-16-34)35-17-14-32-28(35)29(33-26)36-20-22-12-13-31-19-22/h4-11,14,17,22,31H,1-3,12-13,15-16,19-20H2/t22-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111193
PNG
(US9695180, 45)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(CNc3ccon3)cn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H27N7O2/c1-19-2-6-23(7-3-19)27-26(22-8-4-20(14-30)5-9-22)34-29(37-18-21-10-12-31-15-21)28-33-24(17-36(27)28)16-32-25-11-13-38-35-25/h2-9,11,13,17,21,31H,10,12,15-16,18H2,1H3,(H,32,35)/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111562
PNG
(US9695180, 70)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)c(CO)c3)n3ccnc23)C1
Show InChI InChI=1S/C28H29N5O2/c1-19-5-8-23(14-24(19)17-34)26-25(22-9-6-20(15-29)7-10-22)31-28(27-30-11-13-33(26)27)35-18-21-4-3-12-32(2)16-21/h5-11,13-14,21,34H,3-4,12,16-18H2,1-2H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112399
PNG
(US9695180, 90)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3CO)n3ccnc23)C1
Show InChI InChI=1S/C28H29N5O2/c1-19-5-10-24(23(14-19)17-34)26-25(22-8-6-20(15-29)7-9-22)31-28(27-30-11-13-33(26)27)35-18-21-4-3-12-32(2)16-21/h5-11,13-14,21,34H,3-4,12,16-18H2,1-2H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112406
PNG
(US9695180, 93)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3CC(O)Cc3c2)n2ccnc12
Show InChI InChI=1S/C29H30N6O/c1-33(2)24-9-12-34(13-10-24)29-28-31-11-14-35(28)27(22-8-7-21-16-25(36)17-23(21)15-22)26(32-29)20-5-3-19(18-30)4-6-20/h3-8,11,14-15,24-25,36H,9-10,12-13,16-17H2,1-2H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112491
PNG
(US9695180, 110)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)nc(CO)c3c2)n2ccnc12
Show InChI InChI=1S/C29H30N8O/c1-34(2)22-10-13-36(14-11-22)29-28-31-12-15-37(28)27(26(32-29)20-6-4-19(17-30)5-7-20)21-8-9-25-23(16-21)24(18-38)33-35(25)3/h4-9,12,15-16,22,38H,10-11,13-14,18H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112493
PNG
(US9695180, 112)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3n(C)ccc3c2)n2ccnc12
Show InChI InChI=1S/C28H28N8/c1-33(2)23-9-13-35(14-10-23)28-27-30-11-15-36(27)25(22-16-21-8-12-34(3)26(21)31-18-22)24(32-28)20-6-4-19(17-29)5-7-20/h4-8,11-12,15-16,18,23H,9-10,13-14H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112644
PNG
(US9695180, 115)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)c(C)nc3c2)n2ccnc12
Show InChI InChI=1S/C29H30N8/c1-19-32-24-17-22(9-10-25(24)35(19)4)27-26(21-7-5-20(18-30)6-8-21)33-29(28-31-13-16-37(27)28)36-14-11-23(12-15-36)34(2)3/h5-10,13,16-17,23H,11-12,14-15H2,1-4H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111125
PNG
(US9695180, 1)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5O/c1-17-2-6-21(7-3-17)23-22(20-8-4-18(14-26)5-9-20)29-25(24-28-12-13-30(23)24)31-16-19-10-11-27-15-19/h2-9,12-13,19,27H,10-11,15-16H2,1H3/t19-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111208
PNG
(US9695180, 60)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3N(C)C(=O)COc3c2)n2ccnc12
Show InChI InChI=1S/C29H29N7O2/c1-33(2)22-10-13-35(14-11-22)29-28-31-12-15-36(28)27(26(32-29)20-6-4-19(17-30)5-7-20)21-8-9-23-24(16-21)38-18-25(37)34(23)3/h4-9,12,15-16,22H,10-11,13-14,18H2,1-3H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112424
PNG
(US9695180, 100)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCN(C)C2=O)n2ccnc12
Show InChI InChI=1S/C29H31N9O/c1-34(2)23-10-13-36(14-11-23)28-27-31-12-15-38(27)26(25(33-28)21-6-4-20(18-30)5-7-21)22-8-9-24(32-19-22)37-17-16-35(3)29(37)39/h4-9,12,15,19,23H,10-11,13-14,16-17H2,1-3H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111158
PNG
(US9695180, 10)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@H]2CCCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5O/c1-18-4-8-22(9-5-18)24-23(21-10-6-19(15-27)7-11-21)30-26(25-29-13-14-31(24)25)32-17-20-3-2-12-28-16-20/h4-11,13-14,20,28H,2-3,12,16-17H2,1H3/t20-/m0/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111192
PNG
(US9695180, 44)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(CNCC3CC3)cn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H32N6O/c1-20-2-8-25(9-3-20)28-27(24-10-6-21(14-31)7-11-24)35-30(37-19-23-12-13-32-16-23)29-34-26(18-36(28)29)17-33-15-22-4-5-22/h2-3,6-11,18,22-23,32-33H,4-5,12-13,15-17,19H2,1H3/t23-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111194
PNG
(US9695180, 46)
Show SMILES CN(C)Cc1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCN(C)C3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H32N6O/c1-20-5-9-24(10-6-20)27-26(23-11-7-21(15-30)8-12-23)32-29(36-19-22-13-14-34(4)16-22)28-31-25(17-33(2)3)18-35(27)28/h5-12,18,22H,13-14,16-17,19H2,1-4H3/t22-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111195
PNG
(US9695180, 47)
Show SMILES CN(C)CCc1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H32N6O/c1-20-4-8-24(9-5-20)27-26(23-10-6-21(16-30)7-11-23)33-29(36-19-22-12-14-31-17-22)28-32-25(18-35(27)28)13-15-34(2)3/h4-11,18,22,31H,12-15,17,19H2,1-3H3/t22-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111201
PNG
(US9695180, 53)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc4n(C)ccc4c3)n3ccnc23)C1
Show InChI InChI=1S/C28H27N7O/c1-33-11-3-4-20(17-33)18-36-28-27-30-10-13-35(27)25(23-14-22-9-12-34(2)26(22)31-16-23)24(32-28)21-7-5-19(15-29)6-8-21/h5-10,12-14,16,20H,3-4,11,17-18H2,1-2H3/t20-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111800
PNG
(US9695180, 78)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4CC(O)Cc4c3)n3ccnc23)C1
Show InChI InChI=1S/C29H29N5O2/c1-33-11-2-3-20(17-33)18-36-29-28-31-10-12-34(28)27(23-9-8-22-14-25(35)15-24(22)13-23)26(32-29)21-6-4-19(16-30)5-7-21/h4-10,12-13,20,25,35H,2-3,11,14-15,17-18H2,1H3/t20-,25?/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112394
PNG
(US9695180, 88)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc4CCC(O)c4c(F)c3)n3ccnc23)C1
Show InChI InChI=1S/C29H28FN5O2/c1-34-11-2-3-19(16-34)17-37-29-28-32-10-12-35(28)27(26(33-29)20-6-4-18(15-31)5-7-20)22-13-21-8-9-24(36)25(21)23(30)14-22/h4-7,10,12-14,19,24,36H,2-3,8-9,11,16-17H2,1H3/t19-,24?/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112405
PNG
(US9695180, 92)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc(C)c(C)c2)n2ccnc12
Show InChI InChI=1S/C27H29N7/c1-18-15-22(17-30-19(18)2)25-24(21-7-5-20(16-28)6-8-21)31-27(26-29-11-14-34(25)26)33-12-9-23(10-13-33)32(3)4/h5-8,11,14-15,17,23H,9-10,12-13H2,1-4H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112423
PNG
(US9695180, 99)
Show SMILES CN(C)C1CCCN(C1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCCC2=O)n2ccnc12
Show InChI InChI=1S/C29H30N8O/c1-34(2)23-5-3-14-35(19-23)29-28-31-13-16-37(28)27(26(33-29)21-9-7-20(17-30)8-10-21)22-11-12-24(32-18-22)36-15-4-6-25(36)38/h7-13,16,18,23H,3-6,14-15,19H2,1-2H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112452
PNG
(US9695180, 101)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3nccnc3c2)n2ccnc12
Show InChI InChI=1S/C28H26N8/c1-34(2)22-9-14-35(15-10-22)28-27-32-13-16-36(27)26(21-7-8-23-24(17-21)31-12-11-30-23)25(33-28)20-5-3-19(18-29)4-6-20/h3-8,11-13,16-17,22H,9-10,14-15H2,1-2H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111198
PNG
(US9695180, 50)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4OCCOc4c3)n3ccnc23)C1
Show InChI InChI=1S/C28H27N5O3/c1-32-11-2-3-20(17-32)18-36-28-27-30-10-12-33(27)26(22-8-9-23-24(15-22)35-14-13-34-23)25(31-28)21-6-4-19(16-29)5-7-21/h4-10,12,15,20H,2-3,11,13-14,17-18H2,1H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112647
PNG
(US9695180, 116)
Show SMILES COc1cc(cnc1C)-c1c(nc(N2CCC(CC2)N(C)C)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H29N7O/c1-18-23(35-4)15-21(17-30-18)25-24(20-7-5-19(16-28)6-8-20)31-27(26-29-11-14-34(25)26)33-12-9-22(10-13-33)32(2)3/h5-8,11,14-15,17,22H,9-10,12-13H2,1-4H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111204
PNG
(US9695180, 56)
Show SMILES CN(C)[C@H]1CCN(Cc2nc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)N3CCCC3=O)n3ccnc23)C1
Show InChI InChI=1S/C29H30N8O/c1-34(2)23-11-14-35(18-23)19-24-29-31-12-15-37(29)28(27(33-24)21-7-5-20(16-30)6-8-21)22-9-10-25(32-17-22)36-13-3-4-26(36)38/h5-10,12,15,17,23H,3-4,11,13-14,18-19H2,1-2H3/t23-/m0/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111795
PNG
(US9695180, 74)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(CO)cc3)n3ccnc23)C1
Show InChI InChI=1S/C27H27N5O2/c1-31-13-2-3-21(16-31)18-34-27-26-29-12-14-32(26)25(23-10-6-20(17-33)7-11-23)24(30-27)22-8-4-19(15-28)5-9-22/h4-12,14,21,33H,2-3,13,16-18H2,1H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112388
PNG
(US9695180, 84)
Show SMILES COc1ncc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25FN6O2/c1-32-10-3-4-18(15-32)16-35-26-24-29-9-11-33(24)23(20-12-21(27)25(34-2)30-14-20)22(31-26)19-7-5-17(13-28)6-8-19/h5-9,11-12,14,18H,3-4,10,15-16H2,1-2H3/t18-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111151
PNG
(US9695180, 3)
Show SMILES Cc1ccc(cc1)-c1c(nc(CO[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5O/c1-17-2-6-20(7-3-17)24-23(19-8-4-18(14-26)5-9-19)29-22(25-28-12-13-30(24)25)16-31-21-10-11-27-15-21/h2-9,12-13,21,27H,10-11,15-16H2,1H3/t21-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111156
PNG
(US9695180, 8)
Show SMILES CN(C)CCCOc1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C25H25N5O/c1-18-5-9-21(10-6-18)23-22(20-11-7-19(17-26)8-12-20)28-25(24-27-13-15-30(23)24)31-16-4-14-29(2)3/h5-13,15H,4,14,16H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111197
PNG
(US9695180, 49)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4N(C)C(=O)COc4c3)n3ccnc23)C1
Show InChI InChI=1S/C29H28N6O3/c1-33-12-3-4-20(16-33)17-38-29-28-31-11-13-35(28)27(26(32-29)21-7-5-19(15-30)6-8-21)22-9-10-23-24(14-22)37-18-25(36)34(23)2/h5-11,13-14,20H,3-4,12,16-18H2,1-2H3/t20-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111804
PNG
(US9695180, 82)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(CN4CCOCC4)c(F)c3)n3ccnc23)C1
Show InChI InChI=1S/C31H33FN6O2/c1-36-11-2-3-23(19-36)21-40-31-30-34-10-12-38(30)29(28(35-31)24-6-4-22(18-33)5-7-24)25-8-9-26(27(32)17-25)20-37-13-15-39-16-14-37/h4-10,12,17,23H,2-3,11,13-16,19-21H2,1H3/t23-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112648
PNG
(US9695180, 117)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc(C)c(c3)C#N)n3ccnc23)C1
Show InChI InChI=1S/C27H25N7O/c1-18-22(14-29)12-23(15-31-18)25-24(21-7-5-19(13-28)6-8-21)32-27(26-30-9-11-34(25)26)35-17-20-4-3-10-33(2)16-20/h5-9,11-12,15,20H,3-4,10,16-17H2,1-2H3/t20-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111180
PNG
(US9695180, 32)
Show SMILES CN(C)c1ccc(cn1)-c1c(nc(OC[C@@H]2CCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27N7O/c1-31(2)22-9-8-21(15-29-22)24-23(20-6-4-18(14-27)5-7-20)30-26(25-28-11-13-33(24)25)34-17-19-10-12-32(3)16-19/h4-9,11,13,15,19H,10,12,16-17H2,1-3H3/t19-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111799
PNG
(US9695180, 77)
Show SMILES COC(=O)N(C)c1ccc(cc1)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H30N6O3/c1-33-15-4-5-21(18-33)19-38-28-27-31-14-16-35(27)26(25(32-28)22-8-6-20(17-30)7-9-22)23-10-12-24(13-11-23)34(2)29(36)37-3/h6-14,16,21H,4-5,15,18-19H2,1-3H3/t21-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111199
PNG
(US9695180, 51)
Show SMILES CN(C)c1ccc(cn1)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H29N7O/c1-32(2)23-11-10-22(16-30-23)25-24(21-8-6-19(15-28)7-9-21)31-27(26-29-12-14-34(25)26)35-18-20-5-4-13-33(3)17-20/h6-12,14,16,20H,4-5,13,17-18H2,1-3H3/t20-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111202
PNG
(US9695180, 54)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc4n(C)ncc4c3)n3ccnc23)C1
Show InChI InChI=1S/C27H26N8O/c1-33-10-3-4-19(16-33)17-36-27-26-29-9-11-35(26)24(21-12-22-15-31-34(2)25(22)30-14-21)23(32-27)20-7-5-18(13-28)6-8-20/h5-9,11-12,14-15,19H,3-4,10,16-17H2,1-2H3/t19-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112396
PNG
(US9695180, 89)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(CN4CCOCC4)cc3F)n3ccnc23)C1
Show InChI InChI=1S/C31H33FN6O2/c1-36-11-2-3-24(19-36)21-40-31-30-34-10-12-38(30)29(28(35-31)25-7-4-22(18-33)5-8-25)26-9-6-23(17-27(26)32)20-37-13-15-39-16-14-37/h4-10,12,17,24H,2-3,11,13-16,19-21H2,1H3/t24-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111176
PNG
(US9695180, 28)
Show SMILES FC(F)(F)c1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H20F3N5O/c26-25(27,28)20-7-5-19(6-8-20)22-21(18-3-1-16(13-29)2-4-18)32-24(23-31-11-12-33(22)23)34-15-17-9-10-30-14-17/h1-8,11-12,17,30H,9-10,14-15H2/t17-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111893
PNG
(US9695180, 83)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc(F)c(CO)c(F)c3)n3ccnc23)C1
Show InChI InChI=1S/C27H25F2N5O2/c1-33-9-2-3-18(14-33)16-36-27-26-31-8-10-34(26)25(20-11-22(28)21(15-35)23(29)12-20)24(32-27)19-6-4-17(13-30)5-7-19/h4-8,10-12,18,35H,2-3,9,14-16H2,1H3/t18-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112390
PNG
(US9695180, 86)
Show SMILES CC(O)c1ccc(cc1C)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C29H31N5O2/c1-19-15-24(10-11-25(19)20(2)35)27-26(23-8-6-21(16-30)7-9-23)32-29(28-31-12-14-34(27)28)36-18-22-5-4-13-33(3)17-22/h6-12,14-15,20,22,35H,4-5,13,17-18H2,1-3H3/t20?,22-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111164
PNG
(US9695180, 16)
Show SMILES CN1CCCC1CCNc1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C27H28N6/c1-19-5-9-22(10-6-19)25-24(21-11-7-20(18-28)8-12-21)31-26(27-30-15-17-33(25)27)29-14-13-23-4-3-16-32(23)2/h5-12,15,17,23H,3-4,13-14,16H2,1-2H3,(H,29,31)
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111169
PNG
(US9695180, 21)
Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)N(C)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C28H29N7O/c1-19-5-9-22(10-6-19)25-24(21-11-7-20(17-29)8-12-21)31-27(26-30-14-16-35(25)26)33(4)28(36)34-15-13-23(18-34)32(2)3/h5-12,14,16,23H,13,15,18H2,1-4H3/t23-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111175
PNG
(US9695180, 27)
Show SMILES Clc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H20ClN5O/c25-20-7-5-19(6-8-20)22-21(18-3-1-16(13-26)2-4-18)29-24(23-28-11-12-30(22)23)31-15-17-9-10-27-14-17/h1-8,11-12,17,27H,9-10,14-15H2/t17-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111183
PNG
(US9695180, 35)
Show SMILES Cc1ccc(cc1)-c1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCNC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C32H29N5O/c1-21-3-9-25(10-4-21)28-19-37-30(27-11-5-22(2)6-12-27)29(26-13-7-23(17-33)8-14-26)36-32(31(37)35-28)38-20-24-15-16-34-18-24/h3-14,19,24,34H,15-16,18,20H2,1-2H3/t24-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111196
PNG
(US9695180, 48)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)N3CCCC3=O)n3ccnc23)C1
Show InChI InChI=1S/C29H29N7O2/c1-34-13-2-4-21(18-34)19-38-29-28-31-12-15-36(28)27(26(33-29)22-8-6-20(16-30)7-9-22)23-10-11-24(32-17-23)35-14-3-5-25(35)37/h6-12,15,17,21H,2-5,13-14,18-19H2,1H3/t21-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111203
PNG
(US9695180, 55)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4scnc4c3)n3ccnc23)C1
Show InChI InChI=1S/C27H24N6OS/c1-32-11-2-3-19(15-32)16-34-27-26-29-10-12-33(26)25(21-8-9-23-22(13-21)30-17-35-23)24(31-27)20-6-4-18(14-28)5-7-20/h4-10,12-13,17,19H,2-3,11,15-16H2,1H3/t19-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112495
PNG
(US9695180, 114)
Show SMILES C[C@H](O)c1nc2cc(ccc2n1C)-c1c(nc(N2CCC(CC2)N(C)C)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H32N8O/c1-19(39)28-33-24-17-22(9-10-25(24)36(28)4)27-26(21-7-5-20(18-31)6-8-21)34-30(29-32-13-16-38(27)29)37-14-11-23(12-15-37)35(2)3/h5-10,13,16-17,19,23,39H,11-12,14-15H2,1-4H3/t19-/m0/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111171
PNG
(US9695180, 23)
Show SMILES Cc1ccc(cc1)-c1c(nc(NCCc2csc(N)n2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H21N7S/c1-16-2-6-19(7-3-16)22-21(18-8-4-17(14-26)5-9-18)31-23(24-29-12-13-32(22)24)28-11-10-20-15-33-25(27)30-20/h2-9,12-13,15H,10-11H2,1H3,(H2,27,30)(H,28,31)
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111174
PNG
(US9695180, 26)
Show SMILES N#Cc1ccc(cc1)-c1nc(OC[C@@H]2CCNC2)c2nccn2c1-c1ccccc1
Show InChI InChI=1S/C24H21N5O/c25-14-17-6-8-19(9-7-17)21-22(20-4-2-1-3-5-20)29-13-12-27-23(29)24(28-21)30-16-18-10-11-26-15-18/h1-9,12-13,18,26H,10-11,15-16H2/t18-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111179
PNG
(US9695180, 31)
Show SMILES CN(C)c1ncc(cn1)-c1c(nc(OC[C@@H]2CCNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H24N8O/c1-31(2)24-28-13-19(14-29-24)21-20(18-5-3-16(11-25)4-6-18)30-23(22-27-9-10-32(21)22)33-15-17-7-8-26-12-17/h3-6,9-10,13-14,17,26H,7-8,12,15H2,1-2H3/t17-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111796
PNG
(US9695180, 75)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(CN4CCOCC4)cc3)n3ccnc23)C1
Show InChI InChI=1S/C31H34N6O2/c1-35-13-2-3-25(20-35)22-39-31-30-33-12-14-37(30)29(28(34-31)26-8-4-23(19-32)5-9-26)27-10-6-24(7-11-27)21-36-15-17-38-18-16-36/h4-12,14,25H,2-3,13,15-18,20-22H2,1H3/t25-/m1/s1
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112484
PNG
(US9695180, 104)
Show SMILES CN(C)[C@H]1CCN(C1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCCC2=O)n2ccnc12
Show InChI InChI=1S/C28H28N8O/c1-33(2)22-11-14-34(18-22)28-27-30-12-15-36(27)26(25(32-28)20-7-5-19(16-29)6-8-20)21-9-10-23(31-17-21)35-13-3-4-24(35)37/h5-10,12,15,17,22H,3-4,11,13-14,18H2,1-2H3/t22-/m0/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM112488
PNG
(US9695180, 108)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3CCC(=O)N(C)c3c2)n2ccnc12
Show InChI InChI=1S/C30H31N7O/c1-34(2)24-12-15-36(16-13-24)30-29-32-14-17-37(29)28(27(33-30)22-6-4-20(19-31)5-7-22)23-9-8-21-10-11-26(38)35(3)25(21)18-23/h4-9,14,17-18,24H,10-13,15-16H2,1-3H3
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111163
PNG
(US9695180, 15)
Show SMILES CN(C)CCCN(C)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C26H28N6/c1-19-6-10-22(11-7-19)24-23(21-12-8-20(18-27)9-13-21)29-26(25-28-14-17-32(24)25)31(4)16-5-15-30(2)3/h6-14,17H,5,15-16H2,1-4H3
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111165
PNG
(US9695180, 17)
Show SMILES CN1CCC(CC1)Nc1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C26H26N6/c1-18-3-7-21(8-4-18)24-23(20-9-5-19(17-27)6-10-20)30-25(26-28-13-16-32(24)26)29-22-11-14-31(2)15-12-22/h3-10,13,16,22H,11-12,14-15H2,1-2H3,(H,29,30)
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111172
PNG
(US9695180, 24)
Show SMILES Cc1ccc(cc1)-c1c(nc(C(=O)NCC2CNC2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H22N6O/c1-16-2-6-20(7-3-16)23-21(19-8-4-17(12-26)5-9-19)30-22(24-28-10-11-31(23)24)25(32)29-15-18-13-27-14-18/h2-11,18,27H,13-15H2,1H3,(H,29,32)
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10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111173
PNG
(US9695180, 25)
Show SMILES CN1CC(C1)NC(=O)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C25H22N6O/c1-16-3-7-19(8-4-16)23-21(18-9-5-17(13-26)6-10-18)29-22(24-27-11-12-31(23)24)25(32)28-20-14-30(2)15-20/h3-12,20H,14-15H2,1-2H3,(H,28,32)
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111182
PNG
(US9695180, 34)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nc(cn12)C(F)(F)F)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H22F3N5O/c1-16-2-6-20(7-3-16)23-22(19-8-4-17(12-30)5-9-19)33-25(35-15-18-10-11-31-13-18)24-32-21(14-34(23)24)26(27,28)29/h2-9,14,18,31H,10-11,13,15H2,1H3/t18-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111209
PNG
(US9695180, 61)
Show SMILES CCN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc4n(C)ccc4c3)n3ccnc23)C1
Show InChI InChI=1S/C29H29N7O/c1-3-35-12-4-5-21(18-35)19-37-29-28-31-11-14-36(28)26(24-15-23-10-13-34(2)27(23)32-17-24)25(33-29)22-8-6-20(16-30)7-9-22/h6-11,13-15,17,21H,3-5,12,18-19H2,1-2H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111211
PNG
(US9695180, 63)
Show SMILES CCN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4n(C)c(=O)oc4c3)n3ccnc23)C1
Show InChI InChI=1S/C29H28N6O3/c1-3-34-13-4-5-20(17-34)18-37-28-27-31-12-14-35(27)26(25(32-28)21-8-6-19(16-30)7-9-21)22-10-11-23-24(15-22)38-29(36)33(23)2/h6-12,14-15,20H,3-5,13,17-18H2,1-2H3/t20-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111212
PNG
(US9695180, 64)
Show SMILES Cn1c2ccc(cc2oc1=O)-c1c(nc(OC[C@@H]2CCCN(CCC#N)C2)c2nccn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H27N7O3/c1-35-24-10-9-23(16-25(24)40-30(35)38)27-26(22-7-5-20(17-32)6-8-22)34-29(28-33-12-15-37(27)28)39-19-21-4-2-13-36(18-21)14-3-11-31/h5-10,12,15-16,21H,2-4,13-14,18-19H2,1H3/t21-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


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More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111777
PNG
(US9695180, 71)
Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)c(CN4CCN(CC4)S(C)(=O)=O)c3)n3ccnc23)C1
Show InChI InChI=1S/C33H39N7O3S/c1-24-6-9-28(19-29(24)22-38-15-17-39(18-16-38)44(3,41)42)31-30(27-10-7-25(20-34)8-11-27)36-33(32-35-12-14-40(31)32)43-23-26-5-4-13-37(2)21-26/h6-12,14,19,26H,4-5,13,15-18,21-23H2,1-3H3/t26-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111154
PNG
(US9695180, 6)
Show SMILES CN(C)[C@@H]1CCN(CCc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ccnc23)C1
Show InChI InChI=1S/C28H30N6/c1-20-4-8-23(9-5-20)27-26(22-10-6-21(18-29)7-11-22)31-25(28-30-14-17-34(27)28)13-16-33-15-12-24(19-33)32(2)3/h4-11,14,17,24H,12-13,15-16,19H2,1-3H3/t24-/m1/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Human)
BDBM111170
PNG
(US9695180, 22)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)N(C)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n2ccnc12
Show InChI InChI=1S/C28H29N7O/c1-19-5-9-22(10-6-19)25-24(21-11-7-20(17-29)8-12-21)31-27(26-30-14-16-35(25)26)33(4)28(36)34-15-13-23(18-34)32(2)3/h5-12,14,16,23H,13,15,18H2,1-4H3/t23-/m0/s1
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Assay Description
10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%