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Patent code US9695185

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM206760
PNG
(US9260446, (I-S) | US9695185, I-S)
Show SMILES FC(F)(F)c1ccc(CN2C(=O)[C@@]3(COc4cc5OCOc5cc34)c3ccccc23)o1
Show InChI InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
A radiotracer flux assay used to determine ion flux activity of voltage-gated sodium channels in a high-throughput microplate-based format. The assay...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM206762
PNG
(US9260446, (II-S) | US9695185, II-S)
Show SMILES FC(F)(F)c1cccnc1CN1C(=O)[C@@]2(COc3cc4OCCOc4cc23)c2ccccc12
Show InChI InChI=1S/C24H17F3N2O4/c25-24(26,27)14-5-3-7-28-17(14)12-29-18-6-2-1-4-15(18)23(22(29)30)13-33-19-11-21-20(10-16(19)23)31-8-9-32-21/h1-7,10-11H,8-9,12-13H2/t23-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
A radiotracer flux assay used to determine ion flux activity of voltage-gated sodium channels in a high-throughput microplate-based format. The assay...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM206758
PNG
(US9260446, (I) | US9695185, I)
Show SMILES FC(F)(F)c1ccc(CN2C(=O)C3(COc4cc5OCOc5cc34)c3ccccc23)o1
Show InChI InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
A radiotracer flux assay used to determine ion flux activity of voltage-gated sodium channels in a high-throughput microplate-based format. The assay...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM206761
PNG
(US9260446, (II) | US9695185, II)
Show SMILES FC(F)(F)c1cccnc1CN1C(=O)C2(COc3cc4OCCOc4cc23)c2ccccc12
Show InChI InChI=1S/C24H17F3N2O4/c25-24(26,27)14-5-3-7-28-17(14)12-29-18-6-2-1-4-15(18)23(22(29)30)13-33-19-11-21-20(10-16(19)23)31-8-9-32-21/h1-7,10-11H,8-9,12-13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
A radiotracer flux assay used to determine ion flux activity of voltage-gated sodium channels in a high-throughput microplate-based format. The assay...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM206759
PNG
(US9260446, (I-R) | US9695185, I-R)
Show SMILES FC(F)(F)c1ccc(CN2C(=O)[C@]3(COc4cc5OCOc5cc34)c3ccccc23)o1
Show InChI InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
A radiotracer flux assay used to determine ion flux activity of voltage-gated sodium channels in a high-throughput microplate-based format. The assay...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%