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Patent code US9695200

Compile Data Set for Download or QSAR
Found 175 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77948
PNG
(US9695200, 2)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O2/c1-3-17(25)23-13-10-24(11-13)14-7-15-16(9-22-19(15)21-8-14)12-4-5-20-18(6-12)26-2/h3-9,13H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98801
PNG
(US9695200, 35)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C18H16FN5O/c1-2-17(25)23-12-9-24(10-12)13-6-14-15(8-22-18(14)21-7-13)11-3-4-20-16(19)5-11/h2-8,12H,1,9-10H2,(H,21,22)(H,23,25)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98813
PNG
(US9695200, 39)
Show SMILES COc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)26-15-6-4-5-13(7-15)14-8-16-17(11-23-21(16)22-10-14)18-9-20(28-2)25-12-24-18/h3-12H,1H2,2H3,(H,22,23)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100310
PNG
(US9695200, 60)
Show SMILES COc1cc(\C=C(/C#N)C(N)=O)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C24H19N5O3/c1-31-19-7-14(6-17(11-25)23(26)30)5-16(8-19)18-9-20-21(13-29-24(20)28-12-18)15-3-4-27-22(10-15)32-2/h3-10,12-13H,1-2H3,(H2,26,30)(H,28,29)/b17-6+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100765
PNG
(US9695200, 61)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C22H14F4N4O/c1-2-20(31)30-16-6-13(5-15(9-16)22(24,25)26)14-7-17-18(11-29-21(17)28-10-14)12-3-4-27-19(23)8-12/h2-11H,1H2,(H,28,29)(H,30,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100809
PNG
(US9695200, 63)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccc(F)nc3)c2c1)\C#N
Show InChI InChI=1S/C22H14FN5O/c23-20-5-4-15(10-26-20)19-12-28-22-18(19)8-17(11-27-22)14-3-1-2-13(6-14)7-16(9-24)21(25)29/h1-8,10-12H,(H2,25,29)(H,27,28)/b16-7+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM107981
PNG
(US9695200, 78)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(c3)C#N)c2c1
Show InChI InChI=1S/C26H23N5O/c1-31(2)11-5-10-25(32)30-22-9-4-7-19(13-22)21-14-23-24(17-29-26(23)28-16-21)20-8-3-6-18(12-20)15-27/h3-10,12-14,16-17H,11H2,1-2H3,(H,28,29)(H,30,32)/b10-5+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108087
PNG
(US9695200, 81)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C(C)=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-14(2)23(28)27-18-6-4-5-15(9-18)17-10-19-20(13-26-22(19)25-12-17)16-7-8-24-21(11-16)29-3/h4-13H,1H2,2-3H3,(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108335
PNG
(US9695200, 82)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4occc34)c2c1
Show InChI InChI=1S/C24H17N3O2/c1-2-23(28)27-17-6-3-5-15(11-17)16-12-20-21(14-26-24(20)25-13-16)18-7-4-8-22-19(18)9-10-29-22/h2-14H,1H2,(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108388
PNG
(US9695200, 89)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4[nH]ccc34)c2c1
Show InChI InChI=1S/C26H24N6O/c1-32(2)12-4-7-24(33)31-19-6-3-5-17(13-19)18-14-22-23(16-30-26(22)29-15-18)20-8-10-27-25-21(20)9-11-28-25/h3-11,13-16H,12H2,1-2H3,(H,27,28)(H,29,30)(H,31,33)/b7-4+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77950
PNG
(US9695200, 4)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O/c1-3-18(25)23-14-10-24(11-14)15-7-16-17(9-22-19(16)21-8-15)13-4-5-20-12(2)6-13/h3-9,14H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81170
PNG
(US9695200, 7)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C21H16N4O/c1-2-20(26)25-17-5-3-4-15(10-17)16-11-18-19(13-24-21(18)23-12-16)14-6-8-22-9-7-14/h2-13H,1H2,(H,23,24)(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81238
PNG
(US9695200, 8)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C#N
Show InChI InChI=1S/C22H15N5O/c23-11-17(21(24)28)9-14-2-1-3-16(8-14)18-10-19-20(13-27-22(19)26-12-18)15-4-6-25-7-5-15/h1-10,12-13H,(H2,24,28)(H,26,27)/b17-9+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88535
PNG
(US9695200, 20)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-8-14(7-16(10-17)22(23,24)25)15-9-18-19(12-28-21(18)27-11-15)13-3-5-26-6-4-13/h2-12H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88551
PNG
(US9695200, 22)
Show SMILES COc1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H18N4O2/c1-3-21(27)26-17-8-15(9-18(11-17)28-2)16-10-19-20(13-25-22(19)24-12-16)14-4-6-23-7-5-14/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88653
PNG
(US9695200, 25)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-23-19(22)10-14/h2-12H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98786
PNG
(US9695200, 32)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-24-20(11-15)23-2/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98793
PNG
(US9695200, 33)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1
Show InChI InChI=1S/C23H17N5O/c1-14-7-17(5-6-26-14)21-13-28-23-20(21)10-19(12-27-23)16-4-2-3-15(8-16)9-18(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b18-9+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98809
PNG
(US9695200, 38)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN2CCOCC2)c1
Show InChI InChI=1S/C27H27N5O3/c1-34-26-16-20(7-8-28-26)24-18-30-27-23(24)15-21(17-29-27)19-4-2-5-22(14-19)31-25(33)6-3-9-32-10-12-35-13-11-32/h2-8,14-18H,9-13H2,1H3,(H,29,30)(H,31,33)/b6-3+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98821
PNG
(US9695200, 41)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(c1)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-3-23(32)30-21-11-17(12-22(29-21)31-6-8-34-9-7-31)18-10-19-20(15-28-25(19)27-14-18)16-4-5-26-24(13-16)33-2/h3-5,10-15H,1,6-9H2,2H3,(H,27,28)(H,29,30,32)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99795
PNG
(US9695200, 52)
Show SMILES COc1cc(C)cc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)26-17-7-5-6-15(10-17)16-11-18-19(13-25-23(18)24-12-16)20-8-14(2)9-22(27-20)29-3/h4-13H,1H2,2-3H3,(H,24,25)(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99857
PNG
(US9695200, 59)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-7-14(6-16(9-17)22(23,24)25)15-8-18-19(12-28-21(18)27-11-15)13-4-3-5-26-10-13/h2-12H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM101095
PNG
(US9695200, 68)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C(C)=C)nc(OC)c1
Show InChI InChI=1S/C23H21N5O3/c1-13(2)23(29)28-19-8-15(10-21(27-19)31-4)16-7-17-18(12-26-22(17)25-11-16)14-5-6-24-20(9-14)30-3/h5-12H,1H2,2-4H3,(H,25,26)(H,27,28,29)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM107662
PNG
(US9695200, 75)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccncn3)c2c1)\C#N
Show InChI InChI=1S/C21H14N6O/c22-9-15(20(23)28)7-13-2-1-3-14(6-13)16-8-17-18(11-26-21(17)25-10-16)19-4-5-24-12-27-19/h1-8,10-12H,(H2,23,28)(H,25,26)/b15-7+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108346
PNG
(US9695200, 83)
Show SMILES CCC(O)(CC)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C27H28N4O3/c1-5-24(32)31-21-11-18(10-20(14-21)27(33,6-2)7-3)19-12-22-23(16-30-26(22)29-15-19)17-8-9-28-25(13-17)34-4/h5,8-16,33H,1,6-7H2,2-4H3,(H,29,30)(H,31,32)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108395
PNG
(US9695200, 90)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(CC4CC4)c3)c2c1
Show InChI InChI=1S/C28H29N5O2/c1-32(2)12-4-7-26(34)31-23-6-3-5-20(13-23)22-14-24-25(16-30-28(24)29-15-22)21-10-11-27(35)33(18-21)17-19-8-9-19/h3-7,10-11,13-16,18-19H,8-9,12,17H2,1-2H3,(H,29,30)(H,31,34)/b7-4+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108763
PNG
(US9695200, 91)
Show SMILES CNc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H18N6O/c1-3-19(28)26-15-6-4-5-13(9-15)14-10-16-17(12-25-20(16)24-11-14)18-7-8-23-21(22-2)27-18/h3-12H,1H2,2H3,(H,24,25)(H,26,28)(H,22,23,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM70579
PNG
(US9695200, 1)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccccc3)c2c1
Show InChI InChI=1S/C19H18N4O/c1-2-18(24)22-14-11-23(12-14)15-8-16-17(10-21-19(16)20-9-15)13-6-4-3-5-7-13/h2-10,14H,1,11-12H2,(H,20,21)(H,22,24)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77951
PNG
(US9695200, 5)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccnc(c3)C#N)c2c1
Show InChI InChI=1S/C19H16N6O/c1-2-18(26)24-14-10-25(11-14)15-6-16-17(9-23-19(16)22-8-15)12-3-4-21-13(5-12)7-20/h2-6,8-9,14H,1,10-11H2,(H,22,23)(H,24,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87754
PNG
(US9695200, 12)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C21H16N4O/c1-2-20(26)25-17-7-3-5-14(9-17)16-10-18-19(13-24-21(18)23-12-16)15-6-4-8-22-11-15/h2-13H,1H2,(H,23,24)(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87833
PNG
(US9695200, 14)
Show SMILES C=CC(=O)N[C@H]1CCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C19H19N5O/c1-2-18(25)23-14-5-8-24(12-14)15-9-16-17(11-22-19(16)21-10-15)13-3-6-20-7-4-13/h2-4,6-7,9-11,14H,1,5,8,12H2,(H,21,22)(H,23,25)/t14-/m0/s1
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87948
PNG
(US9695200, 16)
Show SMILES C=CC(=O)Nc1cncc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H15N5O/c1-2-19(26)25-16-7-14(9-22-11-16)15-8-17-18(12-24-20(17)23-10-15)13-3-5-21-6-4-13/h2-12H,1H2,(H,23,24)(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98786
PNG
(US9695200, 32)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-24-20(11-15)23-2/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99737
PNG
(US9695200, 46)
Show SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-19(22)23-10-14/h2-12H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99790
PNG
(US9695200, 50)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(CC4CC4)c3)c2c1
Show InChI InChI=1S/C25H22N4O2/c1-2-23(30)28-20-5-3-4-17(10-20)19-11-21-22(13-27-25(21)26-12-19)18-8-9-24(31)29(15-18)14-16-6-7-16/h2-5,8-13,15-16H,1,6-7,14H2,(H,26,27)(H,28,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99796
PNG
(US9695200, 53)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C26H19N3O/c1-2-25(30)29-20-10-5-9-18(13-20)19-14-23-24(16-28-26(23)27-15-19)22-12-6-8-17-7-3-4-11-21(17)22/h2-16H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99802
PNG
(US9695200, 56)
Show SMILES CNc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H18N6O/c1-3-20(28)27-15-6-4-5-13(7-15)14-8-16-17(11-24-21(16)23-10-14)18-9-19(22-2)26-12-25-18/h3-12H,1H2,2H3,(H,23,24)(H,27,28)(H,22,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100784
PNG
(US9695200, 62)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4[nH]ccc34)c2c1
Show InChI InChI=1S/C23H17N5O/c1-2-21(29)28-16-5-3-4-14(10-16)15-11-19-20(13-27-23(19)26-12-15)17-6-8-24-22-18(17)7-9-25-22/h2-13H,1H2,(H,24,25)(H,26,27)(H,28,29)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100870
PNG
(US9695200, 66)
Show SMILES CC(C)(O)Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C25H24N4O3/c1-4-22(30)28-19-7-5-6-16(10-19)18-11-20-21(13-27-24(20)26-12-18)17-8-9-23(31)29(14-17)15-25(2,3)32/h4-14,32H,1,15H2,2-3H3,(H,26,27)(H,28,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108352
PNG
(US9695200, 84)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-29(2)11-5-9-23(30)28-20-8-3-6-17(12-20)19-13-21-22(16-27-24(21)26-15-19)18-7-4-10-25-14-18/h3-10,12-16H,11H2,1-2H3,(H,26,27)(H,28,30)/b9-5+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108388
PNG
(US9695200, 89)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4[nH]ccc34)c2c1
Show InChI InChI=1S/C26H24N6O/c1-32(2)12-4-7-24(33)31-19-6-3-5-17(13-19)18-14-22-23(16-30-26(22)29-15-18)20-8-10-27-25-21(20)9-11-28-25/h3-11,13-16H,12H2,1-2H3,(H,27,28)(H,29,30)(H,31,33)/b7-4+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87738
PNG
(US9695200, 11)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(10-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-27-21(9-13)32-2/h3-12H,1H2,2H3,(H,28,29)(H,30,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM87738
PNG
(US9695200, 11)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(10-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-27-21(9-13)32-2/h3-12H,1H2,2H3,(H,28,29)(H,30,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88374
PNG
(US9695200, 18)
Show SMILES N#CN[C@H]1CCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C17H16N6/c18-11-22-13-3-6-23(10-13)14-7-15-16(9-21-17(15)20-8-14)12-1-4-19-5-2-12/h1-2,4-5,7-9,13,22H,3,6,10H2,(H,20,21)/t13-/m0/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88562
PNG
(US9695200, 24)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-29(2)12-4-7-23(30)28-20-6-3-5-18(13-20)19-14-21-22(16-27-24(21)26-15-19)17-8-10-25-11-9-17/h3-11,13-16H,12H2,1-2H3,(H,26,27)(H,28,30)/b7-4+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98741
PNG
(US9695200, 27)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H14FN5O/c1-2-19(27)26-15-5-13(8-22-10-15)14-6-16-17(11-25-20(16)24-9-14)12-3-4-23-18(21)7-12/h2-11H,1H2,(H,24,25)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98772
PNG
(US9695200, 29)
Show SMILES COc1cc(cc(C)n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)27-18-7-5-6-15(9-18)17-10-19-20(13-25-23(19)24-12-17)16-8-14(2)26-22(11-16)29-3/h4-13H,1H2,2-3H3,(H,24,25)(H,27,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98807
PNG
(US9695200, 37)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C25H25N5O2/c1-30(2)11-5-8-23(31)29-20-7-4-6-17(12-20)19-13-21-22(16-28-25(21)27-15-19)18-9-10-26-24(14-18)32-3/h4-10,12-16H,11H2,1-3H3,(H,27,28)(H,29,31)/b8-5+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99852
PNG
(US9695200, 58)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(9-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-21(32-2)27-10-13/h3-12H,1H2,2H3,(H,28,29)(H,30,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100842
PNG
(US9695200, 65)
Show SMILES COC\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C24H22N4O3/c1-30-10-4-7-22(29)28-19-6-3-5-16(11-19)18-12-20-21(15-27-24(20)26-14-18)17-8-9-25-23(13-17)31-2/h3-9,11-15H,10H2,1-2H3,(H,26,27)(H,28,29)/b7-4+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM107952
PNG
(US9695200, 76)
Show SMILES COc1cc(NC(=O)\C=C\CN(C)C)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C26H27N5O3/c1-31(2)9-5-6-24(32)30-20-10-18(11-21(14-20)33-3)19-12-22-23(16-29-26(22)28-15-19)17-7-8-27-25(13-17)34-4/h5-8,10-16H,9H2,1-4H3,(H,28,29)(H,30,32)/b6-5+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108354
PNG
(US9695200, 85)
Show SMILES CC(=C)C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C22H18N4O/c1-14(2)22(27)26-18-7-3-5-15(9-18)17-10-19-20(13-25-21(19)24-12-17)16-6-4-8-23-11-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77949
PNG
(US9695200, 3)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O2/c1-3-17(25)23-13-10-24(11-13)14-6-15-16(9-22-19(15)21-8-14)12-4-5-18(26-2)20-7-12/h3-9,13H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87774
PNG
(US9695200, 13)
Show SMILES Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)25-17-6-4-5-14(9-17)16-10-18-19(12-24-22(18)23-11-16)15-7-8-21(28)26(2)13-15/h3-13H,1H2,2H3,(H,23,24)(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88373
PNG
(US9695200, 17)
Show SMILES Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)25-16-6-14(8-22-10-16)15-7-17-18(11-24-21(17)23-9-15)13-4-5-20(28)26(2)12-13/h3-12H,1H2,2H3,(H,23,24)(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88558
PNG
(US9695200, 23)
Show SMILES O=C(Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C=C\CN1CCOCC1
Show InChI InChI=1S/C26H25N5O2/c32-25(5-2-10-31-11-13-33-14-12-31)30-22-4-1-3-20(15-22)21-16-23-24(18-29-26(23)28-17-21)19-6-8-27-9-7-19/h1-9,15-18H,10-14H2,(H,28,29)(H,30,32)/b5-2+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88653
PNG
(US9695200, 25)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-23-19(22)10-14/h2-12H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98760
PNG
(US9695200, 28)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-17-7-15(9-22-11-17)16-8-18-19(12-25-21(18)24-10-16)14-4-5-23-13(2)6-14/h3-12H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98781
PNG
(US9695200, 31)
Show SMILES COc1cc(cc(n1)C(F)(F)F)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)29-16-6-4-5-13(7-16)15-8-17-18(12-28-22(17)27-11-15)14-9-19(23(24,25)26)30-21(10-14)32-2/h3-12H,1H2,2H3,(H,27,28)(H,29,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98848
PNG
(US9695200, 42)
Show SMILES Cc1ccccc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H19N3O/c1-3-22(27)26-18-9-6-8-16(11-18)17-12-20-21(14-25-23(20)24-13-17)19-10-5-4-7-15(19)2/h3-14H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98850
PNG
(US9695200, 43)
Show SMILES Clc1cncc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15ClN4O/c1-2-20(27)26-17-5-3-4-13(7-17)14-8-18-19(12-25-21(18)24-10-14)15-6-16(22)11-23-9-15/h2-12H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98918
PNG
(US9695200, 44)
Show SMILES Cc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-16-6-4-5-14(8-16)15-9-17-18(11-23-21(17)22-10-15)19-7-13(2)24-12-25-19/h3-12H,1H2,2H3,(H,22,23)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99786
PNG
(US9695200, 49)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncn3)c2c1
Show InChI InChI=1S/C20H15N5O/c1-2-19(26)25-15-5-3-4-13(8-15)14-9-16-17(11-23-20(16)22-10-14)18-6-7-21-12-24-18/h2-12H,1H2,(H,22,23)(H,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99793
PNG
(US9695200, 51)
Show SMILES COc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H19N3O2/c1-3-22(27)26-18-8-4-6-15(10-18)17-12-20-21(14-25-23(20)24-13-17)16-7-5-9-19(11-16)28-2/h3-14H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100881
PNG
(US9695200, 67)
Show SMILES Cc1ccc(NC(=O)c2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c(C)c1
Show InChI InChI=1S/C31H26N4O2/c1-4-29(36)34-25-7-5-6-23(15-25)24-16-26-27(18-33-30(26)32-17-24)21-9-11-22(12-10-21)31(37)35-28-13-8-19(2)14-20(28)3/h4-18H,1H2,2-3H3,(H,32,33)(H,34,36)(H,35,37)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100881
PNG
(US9695200, 67)
Show SMILES Cc1ccc(NC(=O)c2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c(C)c1
Show InChI InChI=1S/C31H26N4O2/c1-4-29(36)34-25-7-5-6-23(15-25)24-16-26-27(18-33-30(26)32-17-24)21-9-11-22(12-10-21)31(37)35-28-13-8-19(2)14-20(28)3/h4-18H,1H2,2-3H3,(H,32,33)(H,34,36)(H,35,37)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM101100
PNG
(US9695200, 69)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3c[nH]c(=O)c4ccccc34)c2c1
Show InChI InChI=1S/C25H18N4O2/c1-2-23(30)29-17-7-5-6-15(10-17)16-11-20-22(13-27-24(20)26-12-16)21-14-28-25(31)19-9-4-3-8-18(19)21/h2-14H,1H2,(H,26,27)(H,28,31)(H,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM103493
PNG
(US9695200, 73)
Show SMILES Cn1cc(-c2c[nH]c3ncc(cc23)-c2cncc(NC(=O)C=C)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H18N6O2/c1-3-20(30)28-15-6-13(8-24-10-15)14-7-17-18(11-27-22(17)26-9-14)19-12-29(2)23(31)21-16(19)4-5-25-21/h3-12,25H,1H2,2H3,(H,26,27)(H,28,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108375
PNG
(US9695200, 86)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cn(CC4CC4)c(=O)c4ccccc34)c2c1
Show InChI InChI=1S/C29H24N4O2/c1-2-27(34)32-21-7-5-6-19(12-21)20-13-24-25(15-31-28(24)30-14-20)26-17-33(16-18-10-11-18)29(35)23-9-4-3-8-22(23)26/h2-9,12-15,17-18H,1,10-11,16H2,(H,30,31)(H,32,34)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81266
PNG
(US9695200, 9)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1
Show InChI InChI=1S/C23H17N5O2/c1-30-21-10-16(5-6-26-21)20-13-28-23-19(20)9-18(12-27-23)15-4-2-3-14(7-15)8-17(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b17-8+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87847
PNG
(US9695200, 15)
Show SMILES C=CC(=O)N[C@H]1CCCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H21N5O/c1-2-19(26)24-15-4-3-9-25(13-15)16-10-17-18(12-23-20(17)22-11-16)14-5-7-21-8-6-14/h2,5-8,10-12,15H,1,3-4,9,13H2,(H,22,23)(H,24,26)/t15-/m0/s1
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88535
PNG
(US9695200, 20)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-8-14(7-16(10-17)22(23,24)25)15-9-18-19(12-28-21(18)27-11-15)13-3-5-26-6-4-13/h2-12H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88551
PNG
(US9695200, 22)
Show SMILES COc1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H18N4O2/c1-3-21(27)26-17-8-15(9-18(11-17)28-2)16-10-19-20(13-25-22(19)24-12-16)14-4-6-23-7-5-14/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88670
PNG
(US9695200, 26)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O/c1-3-21(27)26-18-6-4-5-15(10-18)17-11-19-20(13-25-22(19)24-12-17)16-7-8-23-14(2)9-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98805
PNG
(US9695200, 36)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H20N6O/c1-3-18(26)24-13-10-25(11-13)14-7-15-16(9-23-19(15)22-8-14)12-4-5-21-17(6-12)20-2/h3-9,13H,1,10-11H2,2H3,(H,20,21)(H,22,23)(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98815
PNG
(US9695200, 40)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(OC)c1
Show InChI InChI=1S/C22H19N5O3/c1-4-19(28)26-18-8-14(10-21(27-18)30-3)15-7-16-17(12-25-22(16)24-11-15)13-5-6-23-20(9-13)29-2/h4-12H,1H2,2-3H3,(H,24,25)(H,26,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99786
PNG
(US9695200, 49)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncn3)c2c1
Show InChI InChI=1S/C20H15N5O/c1-2-19(26)25-15-5-3-4-13(8-15)14-9-16-17(11-23-20(16)22-10-14)18-6-7-21-12-24-18/h2-12H,1H2,(H,22,23)(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99799
PNG
(US9695200, 54)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4ncccc34)c2c1
Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-18-7-3-6-16(12-18)17-13-21-22(15-28-25(21)27-14-17)19-8-4-10-23-20(19)9-5-11-26-23/h2-15H,1H2,(H,27,28)(H,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100765
PNG
(US9695200, 61)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C22H14F4N4O/c1-2-20(31)30-16-6-13(5-15(9-16)22(24,25)26)14-7-17-18(11-29-21(17)28-10-14)12-3-4-27-19(23)8-12/h2-11H,1H2,(H,28,29)(H,30,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM100840
PNG
(US9695200, 64)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4ccccc34)c2c1
Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-18-7-5-6-16(12-18)17-13-21-22(15-28-25(21)27-14-17)19-10-11-26-23-9-4-3-8-20(19)23/h2-15H,1H2,(H,27,28)(H,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM107352
PNG
(US9695200, 74)
Show SMILES CC(C)c1ccc(NC(=O)c2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)cc1
Show InChI InChI=1S/C32H28N4O2/c1-4-30(37)35-27-7-5-6-24(16-27)25-17-28-29(19-34-31(28)33-18-25)22-8-10-23(11-9-22)32(38)36-26-14-12-21(13-15-26)20(2)3/h4-20H,1H2,2-3H3,(H,33,34)(H,35,37)(H,36,38)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM107984
PNG
(US9695200, 79)
Show SMILES COc1cc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c(C)cn1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)27-17-7-5-6-15(8-17)16-9-19-20(13-26-23(19)25-12-16)18-10-22(29-3)24-11-14(18)2/h4-13H,1H2,2-3H3,(H,25,26)(H,27,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108382
PNG
(US9695200, 88)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cn(CC4CC4)c(=O)c4[nH]ccc34)c2c1
Show InChI InChI=1S/C27H23N5O2/c1-2-24(33)31-19-5-3-4-17(10-19)18-11-21-22(13-30-26(21)29-12-18)23-15-32(14-16-6-7-16)27(34)25-20(23)8-9-28-25/h2-5,8-13,15-16,28H,1,6-7,14H2,(H,29,30)(H,31,33)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108763
PNG
(US9695200, 91)
Show SMILES CNc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H18N6O/c1-3-19(28)26-15-6-4-5-13(9-15)14-10-16-17(12-25-20(16)24-11-14)18-7-8-23-21(22-2)27-18/h3-12H,1H2,2H3,(H,24,25)(H,26,28)(H,22,23,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81141
PNG
(US9695200, 6)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-23-21(11-15)28-2/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM81141
PNG
(US9695200, 6)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-23-21(11-15)28-2/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM86369
PNG
(US9695200, 10)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C18H17N5O/c1-2-17(24)22-13-10-23(11-13)14-7-15-16(9-21-18(15)20-8-14)12-3-5-19-6-4-12/h2-9,13H,1,10-11H2,(H,20,21)(H,22,24)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88670
PNG
(US9695200, 26)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O/c1-3-21(27)26-18-6-4-5-15(10-18)17-11-19-20(13-25-22(19)24-12-17)16-7-8-23-14(2)9-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98760
PNG
(US9695200, 28)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-17-7-15(9-22-11-17)16-8-18-19(12-25-21(18)24-10-16)14-4-5-23-13(2)6-14/h3-12H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98779
PNG
(US9695200, 30)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-21(28-2)23-11-15/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98797
PNG
(US9695200, 34)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(C)c3)c2c1
Show InChI InChI=1S/C25H25N5O2/c1-29(2)11-5-8-23(31)28-20-7-4-6-17(12-20)19-13-21-22(15-27-25(21)26-14-19)18-9-10-24(32)30(3)16-18/h4-10,12-16H,11H2,1-3H3,(H,26,27)(H,28,31)/b8-5+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99728
PNG
(US9695200, 45)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(OC(C)C)c1
Show InChI InChI=1S/C24H23N5O3/c1-5-21(30)28-20-9-16(11-23(29-20)32-14(2)3)17-8-18-19(13-27-24(18)26-12-17)15-6-7-25-22(10-15)31-4/h5-14H,1H2,2-4H3,(H,26,27)(H,28,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99790
PNG
(US9695200, 50)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(CC4CC4)c3)c2c1
Show InChI InChI=1S/C25H22N4O2/c1-2-23(30)28-20-5-3-4-17(10-20)19-11-21-22(13-27-25(21)26-12-19)18-8-9-24(31)29(15-18)14-16-6-7-16/h2-5,8-13,15-16H,1,6-7,14H2,(H,26,27)(H,28,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99847
PNG
(US9695200, 57)
Show SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C22H14F4N4O/c1-2-20(31)30-16-6-13(5-15(8-16)22(24,25)26)14-7-17-18(11-29-21(17)28-10-14)12-3-4-19(23)27-9-12/h2-11H,1H2,(H,28,29)(H,30,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100784
PNG
(US9695200, 62)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4[nH]ccc34)c2c1
Show InChI InChI=1S/C23H17N5O/c1-2-21(29)28-16-5-3-4-14(10-16)15-11-19-20(13-27-23(19)26-12-15)17-6-8-24-22-18(17)7-9-25-22/h2-13H,1H2,(H,24,25)(H,26,27)(H,28,29)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM101175
PNG
(US9695200, 70)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C(C)=C)nc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H23N7O2/c1-15(2)26(34)32-23-9-17(8-22(31-23)19-12-30-33(3)14-19)18-7-20-21(13-29-25(20)28-11-18)16-5-6-27-24(10-16)35-4/h5-14H,1H2,2-4H3,(H,28,29)(H,31,32,34)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM103397
PNG
(US9695200, 72)
Show SMILES Cn1cc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c2ccccc2c1=O
Show InChI InChI=1S/C26H20N4O2/c1-3-24(31)29-18-8-6-7-16(11-18)17-12-21-22(14-28-25(21)27-13-17)23-15-30(2)26(32)20-10-5-4-9-19(20)23/h3-15H,1H2,2H3,(H,27,28)(H,29,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM107952
PNG
(US9695200, 76)
Show SMILES COc1cc(NC(=O)\C=C\CN(C)C)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C26H27N5O3/c1-31(2)9-5-6-24(32)30-20-10-18(11-21(14-20)33-3)19-12-22-23(16-29-26(22)28-15-19)17-7-8-27-25(13-17)34-4/h5-8,10-16H,9H2,1-4H3,(H,28,29)(H,30,32)/b6-5+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM107980
PNG
(US9695200, 77)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cncc4[nH]ccc34)c2c1
Show InChI InChI=1S/C23H17N5O/c1-2-22(29)28-16-5-3-4-14(8-16)15-9-18-20(12-27-23(18)26-10-15)19-11-24-13-21-17(19)6-7-25-21/h2-13,25H,1H2,(H,26,27)(H,28,29)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108381
PNG
(US9695200, 87)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C(=C\C(C)C)\C#N)c1
Show InChI InChI=1S/C26H23N5O2/c1-16(2)9-19(13-27)26(32)31-21-6-4-5-17(10-21)20-11-22-23(15-30-25(22)29-14-20)18-7-8-28-24(12-18)33-3/h4-12,14-16H,1-3H3,(H,29,30)(H,31,32)/b19-9+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88391
PNG
(US9695200, 19)
Show SMILES C=CC(=O)Nc1cc(cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)C#N
Show InChI InChI=1S/C22H15N5O/c1-2-21(28)27-18-8-14(11-23)7-16(9-18)17-10-19-20(13-26-22(19)25-12-17)15-3-5-24-6-4-15/h2-10,12-13H,1H2,(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88537
PNG
(US9695200, 21)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C23H20N4O2/c1-4-22(28)27(2)18-7-5-6-15(10-18)17-11-19-20(14-26-23(19)25-13-17)16-8-9-24-21(12-16)29-3/h4-14H,1H2,2-3H3,(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88562
PNG
(US9695200, 24)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-29(2)12-4-7-23(30)28-20-6-3-5-18(13-20)19-14-21-22(16-27-24(21)26-15-19)17-8-10-25-11-9-17/h3-11,13-16H,12H2,1-2H3,(H,26,27)(H,28,30)/b7-4+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98821
PNG
(US9695200, 41)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(c1)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-3-23(32)30-21-11-17(12-22(29-21)31-6-8-34-9-7-31)18-10-19-20(15-28-25(19)27-14-18)16-4-5-26-24(13-16)33-2/h3-5,10-15H,1,6-9H2,2H3,(H,27,28)(H,29,30,32)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99737
PNG
(US9695200, 46)
Show SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-19(22)23-10-14/h2-12H,1H2,(H,24,25)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99777
PNG
(US9695200, 47)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(OCC4CC4)nc3)c2c1
Show InChI InChI=1S/C25H22N4O2/c1-2-23(30)29-20-5-3-4-17(10-20)19-11-21-22(14-28-25(21)27-13-19)18-8-9-24(26-12-18)31-15-16-6-7-16/h2-5,8-14,16H,1,6-7,15H2,(H,27,28)(H,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99779
PNG
(US9695200, 48)
Show SMILES CNc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-20(23-2)24-11-15/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99800
PNG
(US9695200, 55)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4cnccc34)c2c1
Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-19-7-3-5-16(11-19)18-12-22-23(15-28-25(22)27-14-18)21-8-4-6-17-13-26-10-9-20(17)21/h2-15H,1H2,(H,27,28)(H,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99847
PNG
(US9695200, 57)
Show SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C22H14F4N4O/c1-2-20(31)30-16-6-13(5-15(8-16)22(24,25)26)14-7-17-18(11-29-21(17)28-10-14)12-3-4-19(23)27-9-12/h2-11H,1H2,(H,28,29)(H,30,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM99857
PNG
(US9695200, 59)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-7-14(6-16(9-17)22(23,24)25)15-8-18-19(12-28-21(18)27-11-15)13-4-3-5-26-10-13/h2-12H,1H2,(H,27,28)(H,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM102354
PNG
(US9695200, 71)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4[nH]ccc34)c2c1
Show InChI InChI=1S/C24H18N4O/c1-2-23(29)28-17-6-3-5-15(11-17)16-12-20-21(14-27-24(20)26-13-16)18-7-4-8-22-19(18)9-10-25-22/h2-14,25H,1H2,(H,26,27)(H,28,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM103397
PNG
(US9695200, 72)
Show SMILES Cn1cc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c2ccccc2c1=O
Show InChI InChI=1S/C26H20N4O2/c1-3-24(31)29-18-8-6-7-16(11-18)17-12-21-22(14-28-25(21)27-13-17)23-15-30(2)26(32)20-10-5-4-9-19(20)23/h3-15H,1H2,2H3,(H,27,28)(H,29,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM107352
PNG
(US9695200, 74)
Show SMILES CC(C)c1ccc(NC(=O)c2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)cc1
Show InChI InChI=1S/C32H28N4O2/c1-4-30(37)35-27-7-5-6-24(16-27)25-17-28-29(19-34-31(28)33-18-25)22-8-10-23(11-9-22)32(38)36-26-14-12-21(13-15-26)20(2)3/h4-20H,1H2,2-3H3,(H,33,34)(H,35,37)(H,36,38)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108039
PNG
(US9695200, 80)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H22N6O2/c1-4-24(33)31-21-8-17(7-18(9-21)20-13-30-32(2)15-20)19-10-22-23(14-29-26(22)28-12-19)16-5-6-27-25(11-16)34-3/h4-15H,1H2,2-3H3,(H,28,29)(H,31,33)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108039
PNG
(US9695200, 80)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H22N6O2/c1-4-24(33)31-21-8-17(7-18(9-21)20-13-30-32(2)15-20)19-10-22-23(14-29-26(22)28-12-19)16-5-6-27-25(11-16)34-3/h4-15H,1H2,2-3H3,(H,28,29)(H,31,33)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM108810
PNG
(US9695200, 92)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(c3)C#N)c2c1
Show InChI InChI=1S/C23H16N4O/c1-2-22(28)27-19-8-4-6-16(10-19)18-11-20-21(14-26-23(20)25-13-18)17-7-3-5-15(9-17)12-24/h2-11,13-14H,1H2,(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98850
PNG
(US9695200, 43)
Show SMILES Clc1cncc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15ClN4O/c1-2-20(27)26-17-5-3-4-13(7-17)14-8-18-19(12-25-21(18)24-10-14)15-6-16(22)11-23-9-15/h2-12H,1H2,(H,24,25)(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99793
PNG
(US9695200, 51)
Show SMILES COc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H19N3O2/c1-3-22(27)26-18-8-4-6-15(10-18)17-12-20-21(14-25-23(20)24-13-17)16-7-5-9-19(11-16)28-2/h3-14H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99799
PNG
(US9695200, 54)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4ncccc34)c2c1
Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-18-7-3-6-16(12-18)17-13-21-22(15-28-25(21)27-14-17)19-8-4-10-23-20(19)9-5-11-26-23/h2-15H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108346
PNG
(US9695200, 83)
Show SMILES CCC(O)(CC)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C27H28N4O3/c1-5-24(32)31-21-11-18(10-20(14-21)27(33,6-2)7-3)19-12-22-23(16-30-26(22)29-15-19)17-8-9-28-25(13-17)34-4/h5,8-16,33H,1,6-7H2,2-4H3,(H,29,30)(H,31,32)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88558
PNG
(US9695200, 23)
Show SMILES O=C(Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C=C\CN1CCOCC1
Show InChI InChI=1S/C26H25N5O2/c32-25(5-2-10-31-11-13-33-14-12-31)30-22-4-1-3-20(15-22)21-16-23-24(18-29-26(23)28-17-21)19-6-8-27-9-7-19/h1-9,15-18H,10-14H2,(H,28,29)(H,30,32)/b5-2+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98772
PNG
(US9695200, 29)
Show SMILES COc1cc(cc(C)n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)27-18-7-5-6-15(9-18)17-10-19-20(13-25-23(19)24-12-17)16-8-14(2)26-22(11-16)29-3/h4-13H,1H2,2-3H3,(H,24,25)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98779
PNG
(US9695200, 30)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-21(28-2)23-11-15/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98918
PNG
(US9695200, 44)
Show SMILES Cc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-16-6-4-5-14(8-16)15-9-17-18(11-23-21(17)22-10-15)19-7-13(2)24-12-25-19/h3-12H,1H2,2H3,(H,22,23)(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99779
PNG
(US9695200, 48)
Show SMILES CNc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-20(23-2)24-11-15/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100870
PNG
(US9695200, 66)
Show SMILES CC(C)(O)Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C25H24N4O3/c1-4-22(30)28-19-7-5-6-16(10-19)18-11-20-21(13-27-24(20)26-12-18)17-8-9-23(31)29(14-17)15-25(2,3)32/h4-14,32H,1,15H2,2-3H3,(H,26,27)(H,28,30)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98793
PNG
(US9695200, 33)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1
Show InChI InChI=1S/C23H17N5O/c1-14-7-17(5-6-26-14)21-13-28-23-20(21)10-19(12-27-23)16-4-2-3-15(8-16)9-18(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b18-9+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99852
PNG
(US9695200, 58)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(9-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-21(32-2)27-10-13/h3-12H,1H2,2H3,(H,28,29)(H,30,31)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100840
PNG
(US9695200, 64)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4ccccc34)c2c1
Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-18-7-5-6-16(12-18)17-13-21-22(15-28-25(21)27-14-17)19-10-11-26-23-9-4-3-8-20(19)23/h2-15H,1H2,(H,27,28)(H,29,30)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99728
PNG
(US9695200, 45)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(OC(C)C)c1
Show InChI InChI=1S/C24H23N5O3/c1-5-21(30)28-20-9-16(11-23(29-20)32-14(2)3)17-8-18-19(13-27-24(18)26-12-17)15-6-7-25-22(10-15)31-4/h5-14H,1H2,2-4H3,(H,26,27)(H,28,29,30)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98807
PNG
(US9695200, 37)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C25H25N5O2/c1-30(2)11-5-8-23(31)29-20-7-4-6-17(12-20)19-13-21-22(16-28-25(21)27-15-19)18-9-10-26-24(14-18)32-3/h4-10,12-16H,11H2,1-3H3,(H,27,28)(H,29,31)/b8-5+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108352
PNG
(US9695200, 84)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-29(2)11-5-9-23(30)28-20-8-3-6-17(12-20)19-13-21-22(16-27-24(21)26-15-19)18-7-4-10-25-14-18/h3-10,12-16H,11H2,1-2H3,(H,26,27)(H,28,30)/b9-5+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM81238
PNG
(US9695200, 8)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C#N
Show InChI InChI=1S/C22H15N5O/c23-11-17(21(24)28)9-14-2-1-3-16(8-14)18-10-19-20(13-27-22(19)26-12-18)15-4-6-25-7-5-15/h1-10,12-13H,(H2,24,28)(H,26,27)/b17-9+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88537
PNG
(US9695200, 21)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C23H20N4O2/c1-4-22(28)27(2)18-7-5-6-15(10-18)17-11-19-20(14-26-23(19)25-13-17)16-8-9-24-21(12-16)29-3/h4-14H,1H2,2-3H3,(H,25,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM102354
PNG
(US9695200, 71)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4[nH]ccc34)c2c1
Show InChI InChI=1S/C24H18N4O/c1-2-23(29)28-17-6-3-5-15(11-17)16-12-20-21(14-27-24(20)26-13-16)18-7-4-8-22-19(18)9-10-25-22/h2-14,25H,1H2,(H,26,27)(H,28,29)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108810
PNG
(US9695200, 92)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(c3)C#N)c2c1
Show InChI InChI=1S/C23H16N4O/c1-2-22(28)27-19-8-4-6-16(10-19)18-11-20-21(14-26-23(20)25-13-18)17-7-3-5-15(9-17)12-24/h2-11,13-14H,1H2,(H,25,26)(H,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM87754
PNG
(US9695200, 12)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C21H16N4O/c1-2-20(26)25-17-7-3-5-14(9-17)16-10-18-19(13-24-21(18)23-12-16)15-6-4-8-22-11-15/h2-13H,1H2,(H,23,24)(H,25,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98813
PNG
(US9695200, 39)
Show SMILES COc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)26-15-6-4-5-13(7-15)14-8-16-17(11-23-21(16)22-10-14)18-9-20(28-2)25-12-24-18/h3-12H,1H2,2H3,(H,22,23)(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98848
PNG
(US9695200, 42)
Show SMILES Cc1ccccc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H19N3O/c1-3-22(27)26-18-9-6-8-16(11-18)17-12-20-21(14-25-23(20)24-13-17)19-10-5-4-7-15(19)2/h3-14H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99802
PNG
(US9695200, 56)
Show SMILES CNc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H18N6O/c1-3-20(28)27-15-6-4-5-13(7-15)14-8-16-17(11-24-21(16)23-10-14)18-9-19(22-2)26-12-25-18/h3-12H,1H2,2H3,(H,23,24)(H,27,28)(H,22,25,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108382
PNG
(US9695200, 88)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cn(CC4CC4)c(=O)c4[nH]ccc34)c2c1
Show InChI InChI=1S/C27H23N5O2/c1-2-24(33)31-19-5-3-4-17(10-19)18-11-21-22(13-30-26(21)29-12-18)23-15-32(14-16-6-7-16)27(34)25-20(23)8-9-28-25/h2-5,8-13,15-16,28H,1,6-7,14H2,(H,29,30)(H,31,33)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM86369
PNG
(US9695200, 10)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C18H17N5O/c1-2-17(24)22-13-10-23(11-13)14-7-15-16(9-21-18(15)20-8-14)12-3-5-19-6-4-12/h2-9,13H,1,10-11H2,(H,20,21)(H,22,24)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM107984
PNG
(US9695200, 79)
Show SMILES COc1cc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c(C)cn1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)27-17-7-5-6-15(8-17)16-9-19-20(13-26-23(19)25-12-16)18-10-22(29-3)24-11-14(18)2/h4-13H,1H2,2-3H3,(H,25,26)(H,27,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108335
PNG
(US9695200, 82)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4occc34)c2c1
Show InChI InChI=1S/C24H17N3O2/c1-2-23(28)27-17-6-3-5-15(11-17)16-12-20-21(14-26-24(20)25-13-16)18-7-4-8-22-19(18)9-10-29-22/h2-14H,1H2,(H,25,26)(H,27,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM70579
PNG
(US9695200, 1)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccccc3)c2c1
Show InChI InChI=1S/C19H18N4O/c1-2-18(24)22-14-11-23(12-14)15-8-16-17(10-21-19(16)20-9-15)13-6-4-3-5-7-13/h2-10,14H,1,11-12H2,(H,20,21)(H,22,24)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88373
PNG
(US9695200, 17)
Show SMILES Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)25-16-6-14(8-22-10-16)15-7-17-18(11-24-21(17)23-9-15)13-4-5-20(28)26(2)12-13/h3-12H,1H2,2H3,(H,23,24)(H,25,27)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88391
PNG
(US9695200, 19)
Show SMILES C=CC(=O)Nc1cc(cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)C#N
Show InChI InChI=1S/C22H15N5O/c1-2-21(28)27-18-8-14(11-23)7-16(9-18)17-10-19-20(13-26-22(19)25-12-17)15-3-5-24-6-4-15/h2-10,12-13H,1H2,(H,25,26)(H,27,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM77950
PNG
(US9695200, 4)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O/c1-3-18(25)23-14-10-24(11-14)15-7-16-17(9-22-19(16)21-8-15)13-4-5-20-12(2)6-13/h3-9,14H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98797
PNG
(US9695200, 34)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(C)c3)c2c1
Show InChI InChI=1S/C25H25N5O2/c1-29(2)11-5-8-23(31)28-20-7-4-6-17(12-20)19-13-21-22(15-27-25(21)26-14-19)18-9-10-24(32)30(3)16-18/h4-10,12-16H,11H2,1-3H3,(H,26,27)(H,28,31)/b8-5+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99800
PNG
(US9695200, 55)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4cnccc34)c2c1
Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-19-7-3-5-16(11-19)18-12-22-23(15-28-25(22)27-14-18)21-8-4-6-17-13-26-10-9-20(17)21/h2-15H,1H2,(H,27,28)(H,29,30)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108375
PNG
(US9695200, 86)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cn(CC4CC4)c(=O)c4ccccc34)c2c1
Show InChI InChI=1S/C29H24N4O2/c1-2-27(34)32-21-7-5-6-19(12-21)20-13-24-25(15-31-28(24)30-14-20)26-17-33(16-18-10-11-18)29(35)23-9-4-3-8-22(23)26/h2-9,12-15,17-18H,1,10-11,16H2,(H,30,31)(H,32,34)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM77951
PNG
(US9695200, 5)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccnc(c3)C#N)c2c1
Show InChI InChI=1S/C19H16N6O/c1-2-18(26)24-14-10-25(11-14)15-6-16-17(9-23-19(16)22-8-15)12-3-4-21-13(5-12)7-20/h2-6,8-9,14H,1,10-11H2,(H,22,23)(H,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM87833
PNG
(US9695200, 14)
Show SMILES C=CC(=O)N[C@H]1CCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C19H19N5O/c1-2-18(25)23-14-5-8-24(12-14)15-9-16-17(11-22-19(16)21-10-15)13-3-6-20-7-4-13/h2-4,6-7,9-11,14H,1,5,8,12H2,(H,21,22)(H,23,25)/t14-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98801
PNG
(US9695200, 35)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C18H16FN5O/c1-2-17(25)23-12-9-24(10-12)13-6-14-15(8-22-18(14)21-7-13)11-3-4-20-16(19)5-11/h2-8,12H,1,9-10H2,(H,21,22)(H,23,25)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99796
PNG
(US9695200, 53)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C26H19N3O/c1-2-25(30)29-20-10-5-9-18(13-20)19-14-23-24(16-28-26(23)27-15-19)22-12-6-8-17-7-3-4-11-21(17)22/h2-16H,1H2,(H,27,28)(H,29,30)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100310
PNG
(US9695200, 60)
Show SMILES COc1cc(\C=C(/C#N)C(N)=O)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C24H19N5O3/c1-31-19-7-14(6-17(11-25)23(26)30)5-16(8-19)18-9-20-21(13-29-24(20)28-12-18)15-3-4-27-22(10-15)32-2/h3-10,12-13H,1-2H3,(H2,26,30)(H,28,29)/b17-6+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100842
PNG
(US9695200, 65)
Show SMILES COC\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1
Show InChI InChI=1S/C24H22N4O3/c1-30-10-4-7-22(29)28-19-6-3-5-16(11-19)18-12-20-21(15-27-24(20)26-14-18)17-8-9-25-23(13-17)31-2/h3-9,11-15H,10H2,1-2H3,(H,26,27)(H,28,29)/b7-4+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM101100
PNG
(US9695200, 69)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3c[nH]c(=O)c4ccccc34)c2c1
Show InChI InChI=1S/C25H18N4O2/c1-2-23(30)29-17-7-5-6-15(10-17)16-11-20-22(13-27-24(20)26-12-16)21-14-28-25(31)19-9-4-3-8-18(19)21/h2-14H,1H2,(H,26,27)(H,28,31)(H,29,30)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM101175
PNG
(US9695200, 70)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C(C)=C)nc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H23N7O2/c1-15(2)26(34)32-23-9-17(8-22(31-23)19-12-30-33(3)14-19)18-7-20-21(13-29-25(20)28-11-18)16-5-6-27-24(10-16)35-4/h5-14H,1H2,2-4H3,(H,28,29)(H,31,32,34)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108381
PNG
(US9695200, 87)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C(=C\C(C)C)\C#N)c1
Show InChI InChI=1S/C26H23N5O2/c1-16(2)9-19(13-27)26(32)31-21-6-4-5-17(10-21)20-11-22-23(15-30-25(22)29-14-20)18-7-8-28-24(12-18)33-3/h4-12,14-16H,1-3H3,(H,29,30)(H,31,32)/b19-9+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98809
PNG
(US9695200, 38)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN2CCOCC2)c1
Show InChI InChI=1S/C27H27N5O3/c1-34-26-16-20(7-8-28-26)24-18-30-27-23(24)15-21(17-29-27)19-4-2-5-22(14-19)31-25(33)6-3-9-32-10-12-35-13-11-32/h2-8,14-18H,9-13H2,1H3,(H,29,30)(H,31,33)/b6-3+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM103493
PNG
(US9695200, 73)
Show SMILES Cn1cc(-c2c[nH]c3ncc(cc23)-c2cncc(NC(=O)C=C)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H18N6O2/c1-3-20(30)28-15-6-13(8-24-10-15)14-7-17-18(11-27-22(17)26-9-14)19-12-29(2)23(31)21-16(19)4-5-25-21/h3-12,25H,1H2,2H3,(H,26,27)(H,28,30)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM107980
PNG
(US9695200, 77)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cncc4[nH]ccc34)c2c1
Show InChI InChI=1S/C23H17N5O/c1-2-22(29)28-16-5-3-4-14(8-16)15-9-18-20(12-27-23(18)26-10-15)19-11-24-13-21-17(19)6-7-25-21/h2-13,25H,1H2,(H,26,27)(H,28,29)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108087
PNG
(US9695200, 81)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C(C)=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-14(2)23(28)27-18-6-4-5-15(9-18)17-10-19-20(13-26-22(19)25-12-17)16-7-8-24-21(11-16)29-3/h4-13H,1H2,2-3H3,(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98805
PNG
(US9695200, 36)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H20N6O/c1-3-18(26)24-13-10-25(11-13)14-7-15-16(9-23-19(15)22-8-14)12-4-5-21-17(6-12)20-2/h3-9,13H,1,10-11H2,2H3,(H,20,21)(H,22,23)(H,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM100809
PNG
(US9695200, 63)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccc(F)nc3)c2c1)\C#N
Show InChI InChI=1S/C22H14FN5O/c23-20-5-4-15(10-26-20)19-12-28-22-18(19)8-17(11-27-22)14-3-1-2-13(6-14)7-16(9-24)21(25)29/h1-8,10-12H,(H2,25,29)(H,27,28)/b16-7+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM107981
PNG
(US9695200, 78)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(c3)C#N)c2c1
Show InChI InChI=1S/C26H23N5O/c1-31(2)11-5-10-25(32)30-22-9-4-7-19(13-22)21-14-23-24(17-29-26(23)28-16-21)20-8-3-6-18(12-20)15-27/h3-10,12-14,16-17H,11H2,1-2H3,(H,28,29)(H,30,32)/b10-5+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108354
PNG
(US9695200, 85)
Show SMILES CC(=C)C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C22H18N4O/c1-14(2)22(27)26-18-7-3-5-15(9-18)17-10-19-20(13-25-21(19)24-12-17)16-6-4-8-23-11-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM108395
PNG
(US9695200, 90)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(CC4CC4)c3)c2c1
Show InChI InChI=1S/C28H29N5O2/c1-32(2)12-4-7-26(34)31-23-6-3-5-20(13-23)22-14-24-25(16-30-28(24)29-15-22)21-10-11-27(35)33(18-21)17-19-8-9-19/h3-7,10-11,13-16,18-19H,8-9,12,17H2,1-2H3,(H,29,30)(H,31,34)/b7-4+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM101095
PNG
(US9695200, 68)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C(C)=C)nc(OC)c1
Show InChI InChI=1S/C23H21N5O3/c1-13(2)23(29)28-19-8-15(10-21(27-19)31-4)16-7-17-18(12-26-22(17)25-11-16)14-5-6-24-20(9-14)30-3/h5-12H,1H2,2-4H3,(H,25,26)(H,27,28,29)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM81266
PNG
(US9695200, 9)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1
Show InChI InChI=1S/C23H17N5O2/c1-30-21-10-16(5-6-26-21)20-13-28-23-19(20)9-18(12-27-23)15-4-2-3-14(7-15)8-17(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b17-8+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM87847
PNG
(US9695200, 15)
Show SMILES C=CC(=O)N[C@H]1CCCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H21N5O/c1-2-19(26)24-15-4-3-9-25(13-15)16-10-17-18(12-23-20(17)22-11-16)14-5-7-21-8-6-14/h2,5-8,10-12,15H,1,3-4,9,13H2,(H,22,23)(H,24,26)/t15-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM99795
PNG
(US9695200, 52)
Show SMILES COc1cc(C)cc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)26-17-7-5-6-15(10-17)16-11-18-19(13-25-23(18)24-12-16)20-8-14(2)9-22(27-20)29-3/h4-13H,1H2,2-3H3,(H,24,25)(H,26,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM107662
PNG
(US9695200, 75)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccncn3)c2c1)\C#N
Show InChI InChI=1S/C21H14N6O/c22-9-15(20(23)28)7-13-2-1-3-14(6-13)16-8-17-18(11-26-21(17)25-10-16)19-4-5-24-12-27-19/h1-8,10-12H,(H2,23,28)(H,25,26)/b15-7+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98781
PNG
(US9695200, 31)
Show SMILES COc1cc(cc(n1)C(F)(F)F)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)29-16-6-4-5-13(7-16)15-8-17-18(12-28-22(17)27-11-15)14-9-19(23(24,25)26)30-21(10-14)32-2/h3-12H,1H2,2H3,(H,27,28)(H,29,31)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%