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Patent code US9701638

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247019
PNG
(US9701638, 10)
Show SMILES Oc1cc2ccc(cc2[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNO2/c16-12-5-3-9(4-6-12)10-1-2-11-8-14(18)15(19)17-13(11)7-10/h1-8,18H,(H,17,19)
PDB

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UniChem
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US Patent
n/an/a 560n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247018
PNG
(US9701638, 9)
Show SMILES Oc1cc2cc(ccc2[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNO2/c16-12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(18)15(19)17-13/h1-8,18H,(H,17,19)
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US Patent
n/an/a 560n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247021
PNG
(US9701638, 12)
Show SMILES Oc1c(Br)c2ccc(cc2[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C15H9BrFNO2/c16-13-11-6-3-9(8-1-4-10(17)5-2-8)7-12(11)18-15(20)14(13)19/h1-7,19H,(H,18,20)
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US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247024
PNG
(US9701638, 15)
Show SMILES Oc1c(-c2ccccc2)c2ccc(cc2[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14FNO2/c22-16-9-6-13(7-10-16)15-8-11-17-18(12-15)23-21(25)20(24)19(17)14-4-2-1-3-5-14/h1-12,24H,(H,23,25)
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US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247017
PNG
(US9701638, 8)
Show SMILES CC.Oc1cc2c(cccc2[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNO2.C2H6/c16-10-6-4-9(5-7-10)11-2-1-3-13-12(11)8-14(18)15(19)17-13;1-2/h1-8,18H,(H,17,19);1-2H3
PDB

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US Patent
n/an/a 3.30E+3n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247020
PNG
(US9701638, 11)
Show SMILES Oc1cc2cccc(-c3ccc(F)cc3)c2[nH]c1=O
Show InChI InChI=1S/C15H10FNO2/c16-11-6-4-9(5-7-11)12-3-1-2-10-8-13(18)15(19)17-14(10)12/h1-8,18H,(H,17,19)
PDB

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UniChem
Article
US Patent
n/an/a 4.70E+3n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247013
PNG
(US9701638, 4)
Show SMILES Oc1cc2cc(Br)ccc2[nH]c1=O
Show InChI InChI=1S/C9H6BrNO2/c10-6-1-2-7-5(3-6)4-8(12)9(13)11-7/h1-4,12H,(H,11,13)
PDB

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US Patent
n/an/a 7.40E+3n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247014
PNG
(US9701638, 5)
Show SMILES Oc1cc2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C9H6BrNO2/c10-6-2-1-5-3-8(12)9(13)11-7(5)4-6/h1-4,12H,(H,11,13)
PDB

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Article
US Patent
n/an/a 7.60E+3n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247015
PNG
(US9701638, 6)
Show SMILES Oc1cc2cccc(Br)c2[nH]c1=O
Show InChI InChI=1S/C9H6BrNO2/c10-6-3-1-2-5-4-7(12)9(13)11-8(5)6/h1-4,12H,(H,11,13)
PDB

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Article
US Patent
n/an/a 1.06E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247016
PNG
(US9701638, 7)
Show SMILES Oc1c(-c2ccc(F)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C15H10FNO2/c16-10-7-5-9(6-8-10)13-11-3-1-2-4-12(11)17-15(19)14(13)18/h1-8,18H,(H,17,19)
PDB

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Article
US Patent
n/an/a 1.08E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247012
PNG
(US9701638, 3)
Show SMILES Oc1cc2c(Br)cccc2[nH]c1=O
Show InChI InChI=1S/C9H6BrNO2/c10-6-2-1-3-7-5(6)4-8(12)9(13)11-7/h1-4,12H,(H,11,13)
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US Patent
n/an/a 1.22E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247025
PNG
(US9701638, 16)
Show SMILES Cc1c(O)c(=O)[nH]c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO2/c1-9-13-7-4-11(10-2-5-12(17)6-3-10)8-14(13)18-16(20)15(9)19/h2-8,19H,1H3,(H,18,20)
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US Patent
n/an/a 1.32E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247022
PNG
(US9701638, 13)
Show SMILES Oc1c(-c2ccccc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C15H11NO2/c17-14-13(10-6-2-1-3-7-10)11-8-4-5-9-12(11)16-15(14)18/h1-9,17H,(H,16,18)
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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM31148
PNG
(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Show SMILES Oc1cc2ccccc2[nH]c1=O
Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12)
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US Patent
n/an/a 2.40E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM247011
PNG
(US9701638, 2)
Show SMILES Oc1c(Br)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C9H6BrNO2/c10-7-5-3-1-2-4-6(5)11-9(13)8(7)12/h1-4,12H,(H,11,13)
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n/an/a 5.30E+4n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
Hemagglutinin


(Influenza A virus (strain swl A/California/04/2009...)
BDBM31169
PNG
(3-hydroxyquinolin-2(1H)-one, 23 | US9701638, 14)
Show SMILES Cc1c(O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C10H9NO2/c1-6-7-4-2-3-5-8(7)11-10(13)9(6)12/h2-5,12H,1H3,(H,11,13)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Rutgers, The State University of New Jersey

US Patent


Assay Description
The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...


US Patent US9701638 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%