BindingDB logo
myBDB logout

Patent code US9707233

Compile Data Set for Download or QSAR

Found 368 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110delta/p85alpha


(Homo sapiens (human))
BDBM255797
PNG
(1-{1-[3-(1-sec-butylazetidin-3-yl)-5-chloro-2-meth...)
Show SMILES CCC(C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H31ClN6O/c1-7-12(2)29-9-16(10-29)19-13(3)18(24)8-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255798
PNG
(1-(1-{5-Chloro-2-methoxy-3-[1-(2-methoxyethyl)azet...)
Show SMILES COCCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C22H29ClN6O2/c1-12-17(23)8-16(20(31-5)18(12)15-9-28(10-15)6-7-30-4)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h8,11,14-15H,6-7,9-10H2,1-5H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255799
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C21H26ClN7O2/c1-10-15(22)6-14(18(31-5)16(10)13-7-28(8-13)21(30)24-4)12(3)29-20-17(11(2)27-29)19(23)25-9-26-20/h6,9,12-13H,7-8H2,1-5H3,(H,24,30)(H2,23,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255814
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)10-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-19(28-11-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255823
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255826
PNG
(4-Amino-8-{1-[5-chloro-2-ethoxy-3-(1-isopropylazet...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-6-32-22-17(9-18(25)14(4)20(22)16-10-29(11-16)13(2)3)15(5)30-8-7-19(31)21-23(26)27-12-28-24(21)30/h7-9,12-13,15-16H,6,10-11H2,1-5H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255841
PNG
(5-(3-{1-[4-amino-3-(1-methyl-1H-pyrazol-3-yl)-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccn(C)n2)c2c(N)ncnc12
Show InChI InChI=1S/C28H30ClN9O2/c1-7-40-25-18(12-19(29)15(2)22(25)17-8-9-21(31-13-17)28(39)36(4)5)16(3)38-27-23(26(30)32-14-33-27)24(35-38)20-10-11-37(6)34-20/h8-14,16H,7H2,1-6H3,(H2,30,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255849
PNG
(5-(3-{1-[4-amino-3-(2-aminopyrimidin-5-yl)-1H-pyra...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cnc(N)nc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H29ClN10O2/c1-6-41-24-18(9-19(29)14(2)21(24)16-7-8-20(32-10-16)27(40)38(4)5)15(3)39-26-22(25(30)35-13-36-26)23(37-39)17-11-33-28(31)34-12-17/h7-13,15H,6H2,1-5H3,(H2,30,35,36)(H2,31,33,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255864
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-9(2)30-6-11(7-30)14-16(23)13(22)5-12(18(14)32-4)10(3)31-21-15(17(29-31)19(24)25)20(26)27-8-28-21/h5,8-11,19H,6-7H2,1-4H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM259101
PNG
(5-[3-(1-{4-Amino-3-[(3R)-3-hydroxybut-1-yn-1-yl]-1...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C#C[C@@H](C)O)c2c(N)ncnc12
Show InChI InChI=1S/C28H30ClN7O3/c1-7-39-25-19(12-20(29)16(3)23(25)18-9-11-22(31-13-18)28(38)35(5)6)17(4)36-27-24(26(30)32-14-33-27)21(34-36)10-8-15(2)37/h9,11-15,17,37H,7H2,1-6H3,(H2,30,32,33)/t15-,17?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261063
PNG
(5-(3-{1-[4-Amino-3-(fluoromethyl)-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CF)c2c(N)ncnc12
Show InChI InChI=1S/C25H27ClFN7O2/c1-6-36-22-16(14(3)34-24-21(19(10-27)32-34)23(28)30-12-31-24)9-17(26)13(2)20(22)15-7-8-18(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6,10H2,1-5H3,(H2,28,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261068
PNG
(3-{1-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(-c3cnc4[nH]ccc4c3)c3c(N)ncnc23)c1OCC
Show InChI InChI=1S/C26H27ClN8O2/c1-5-29-26(36)19-13(3)18(27)10-17(22(19)37-6-2)14(4)35-25-20(23(28)32-12-33-25)21(34-35)16-9-15-7-8-30-24(15)31-11-16/h7-12,14H,5-6H2,1-4H3,(H,29,36)(H,30,31)(H2,28,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261099
PNG
(1-[(3-{3-[1-(4-Amino-3-methyl- 1H-pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C1(O)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H27ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-4)17(11)14-8-29(9-14)22(31)23(32)5-6-23/h7,10,13-14,32H,5-6,8-9H2,1-4H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261108
PNG
(5-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-15(9-31)17-12(2)14(6-26)5-16(20(17)34-4)13(3)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h5,10-11,13,15,21,33H,7-9H2,1-4H3,(H2,27,28,29)/t11-,13?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261122
PNG
(1-{1-[5-Chloro-2-ethoxy-4-fluoro- 3-(1-methylazeti...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H24ClFN6O/c1-5-29-18-13(6-14(21)17(22)16(18)12-7-27(4)8-12)11(3)28-20-15(10(2)26-28)19(23)24-9-25-20/h6,9,11-12H,5,7-8H2,1-4H3,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261135
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O2/c1-12-17(24)7-16(14(3)30-22-19(13(2)28-30)21(25)26-11-27-22)20(32-6)18(12)15-8-29(9-15)10-23(4,5)31/h7,11,14-15,31H,8-10H2,1-6H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261140
PNG
(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O/c1-12-17(23)10-16(20(30-5)18(12)15-6-8-28(4)9-7-15)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h10-11,14-15H,6-9H2,1-5H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261146
PNG
(1-(1-(3-(2-aminopyrimidin-5-yl)-5- chloro-2-methox...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnc(N)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21ClN8O/c1-9-14(21)5-13(17(30-4)15(9)12-6-24-20(23)25-7-12)11(3)29-19-16(10(2)28-29)18(22)26-8-27-19/h5-8,11H,1-4H3,(H2,22,26,27)(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261153
PNG
(1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CCC(O)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C27H30ClN7O3/c1-14-21(28)10-20(16(3)35-26-23(15(2)33-35)25(29)31-13-32-26)24(38-4)22(14)17-9-18(12-30-11-17)27(37)34-7-5-19(36)6-8-34/h9-13,16,19,36H,5-8H2,1-4H3,(H2,29,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261154
PNG
(1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CC(C1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H25ClN8O2/c1-13-20(27)6-19(15(3)35-25-22(14(2)33-35)24(29)31-12-32-25)23(37-4)21(13)17-5-18(9-30-8-17)26(36)34-10-16(7-28)11-34/h5-6,8-9,12,15-16H,10-11H2,1-4H3,(H2,29,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261175
PNG
(1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(5-(methylsulf...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN6O3S/c1-6-33-21-17(14(4)30-23-20(13(3)29-30)22(25)27-11-28-23)8-18(24)12(2)19(21)15-7-16(10-26-9-15)34(5,31)32/h7-11,14H,6H2,1-5H3,(H2,25,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261191
PNG
(US9707233, 214)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-5-29-9-14(10-29)19-16(8-24)17(23)7-15(20(19)31-6-2)13(4)30-22-18(12(3)28-30)21(25)26-11-27-22/h7,11,13-14H,5-6,9-10H2,1-4H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261197
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-9-30(10-15)8-12(2)32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12-,14?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261200
PNG
(US9707233, 223)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12?,14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261201
PNG
(US9707233, 224)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12?,14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261240
PNG
(US9707233, 263)
Show SMILES CCN1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-5-28-8-13(9-28)18-15(7-23)16(22)6-14(19(18)30-4)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261242
PNG
(US9707233, 265)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O/c1-12(2)8-30-9-15(10-30)20-17(7-25)18(24)6-16(21(20)32-5)14(4)31-23-19(13(3)29-31)22(26)27-11-28-23/h6,11-12,14-15H,8-10H2,1-5H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261248
PNG
(US9707233, 271)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-12-18-21(26)27-11-28-22(18)31(29-12)13(2)15-6-17(24)16(7-25)19(20(15)33-5)14-8-30(9-14)10-23(3,4)32/h6,11,13-14,32H,8-10H2,1-5H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261251
PNG
(US9707233, 274)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-11-18-21(25)26-10-27-22(18)30(28-11)12(2)15-4-17(23)16(5-24)19(20(15)31-3)13-6-29(7-13)14-8-32-9-14/h4,10,12-14H,6-9H2,1-3H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261257
PNG
(US9707233, 280)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CC2CCOCC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H30ClN7O2/c1-14-21-24(28)29-13-30-25(21)33(31-14)15(2)18-8-20(26)19(9-27)22(23(18)34-3)17-11-32(12-17)10-16-4-6-35-7-5-16/h8,13,15-17H,4-7,10-12H2,1-3H3,(H2,28,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261260
PNG
(US9707233, 283)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O2/c1-11(2)23(32)30-8-14(9-30)19-16(7-25)17(24)6-15(20(19)33-5)13(4)31-22-18(12(3)29-31)21(26)27-10-28-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261261
PNG
(US9707233, 284)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H24ClN7O2/c1-11-18-21(26)27-10-28-22(18)31(29-11)12(2)15-6-17(24)16(7-25)19(20(15)33-3)14-8-30(9-14)23(32)13-4-5-13/h6,10,12-14H,4-5,8-9H2,1-3H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261266
PNG
(Methyl 3-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d...)
Show SMILES COC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O3/c1-10-16-19(24)25-9-26-20(16)29(27-10)11(2)13-5-15(22)14(6-23)17(18(13)31-3)12-7-28(8-12)21(30)32-4/h5,9,11-12H,7-8H2,1-4H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261271
PNG
(US9707233, 294)
Show SMILES CNC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H23ClN8O2/c1-10-16-19(24)26-9-27-20(16)30(28-10)11(2)13-5-15(22)14(6-23)17(18(13)32-4)12-7-29(8-12)21(31)25-3/h5,9,11-12H,7-8H2,1-4H3,(H,25,31)(H2,24,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261286
PNG
(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1cc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN6O2/c1-5-33-22-17(15(4)31-8-13(2)20-23(27)28-12-29-24(20)31)6-19(25)18(7-26)21(22)16-10-30(11-16)9-14(3)32/h6,8,12,14-16,32H,5,9-11H2,1-4H3,(H2,27,28,29)/t14-,15?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261289
PNG
(4-[-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Show SMILES COc1c(cc(C)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29N7O2/c1-12-6-17(15(4)30-23-19(14(3)28-30)22(25)26-11-27-23)21(32-5)20(18(12)7-24)16-9-29(10-16)8-13(2)31/h6,11,13,15-16,31H,8-10H2,1-5H3,(H2,25,26,27)/t13-,15?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261292
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CCCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-4-30-19-14(9-16(22)15(10-23)18(19)28-7-5-6-8-28)13(3)29-21-17(12(2)27-29)20(24)25-11-26-21/h9,11,13H,4-8H2,1-3H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261299
PNG
(US9707233, 328)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H33N7O2/c1-7-34-22-18(16(4)32-24-20(15(3)30-32)23(27)28-13-29-24)8-14(2)19(9-26)21(22)17-10-31(11-17)12-25(5,6)33/h8,13,16-17,33H,7,10-12H2,1-6H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261329
PNG
(US9707233, 349 | US9707233, 351 | US9707233, 352)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261334
PNG
(S-4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyri...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1COC(=O)N1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-30-19(28)25-12)9(3)27-18-13(8(2)26-27)17(22)23-7-24-18/h5,7,9,12H,4,6H2,1-3H3,(H,25,28)(H2,22,23,24)/t9-,12?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255793
PNG
(1-(1-{5-Chloro-3-[1-(cyclopropylmethyl)azetidin-3-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O/c1-12-18(24)7-17(14(3)30-23-20(13(2)28-30)22(25)26-11-27-23)21(31-4)19(12)16-9-29(10-16)8-15-5-6-15/h7,11,14-16H,5-6,8-10H2,1-4H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255805
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)11-18(26)13(2)20(22)16-8-9-28-19(10-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255806
PNG
(4-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)c1cc(ccn1)-c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H24ClN7O2/c1-11-16(24)9-15(13(3)31-22-19(12(2)30-31)21(25)28-10-29-22)20(33-5)18(11)14-6-7-27-17(8-14)23(32)26-4/h6-10,13H,1-5H3,(H,26,32)(H2,25,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255817
PNG
(4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255825
PNG
(4-Amino-8-{1-[5-chloro-3-(1-isopropylazetidin-3-yl...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN5O2/c1-12(2)28-9-15(10-28)19-13(3)17(24)8-16(21(19)31-5)14(4)29-7-6-18(30)20-22(25)26-11-27-23(20)29/h6-8,11-12,14-15H,9-10H2,1-5H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255850
PNG
(5-{3-[1-(4-amino-3-{6-[(methylamino)carbonyl]pyrid...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccc(nc2)C(=O)NC)c2c(N)ncnc12
Show InChI InChI=1S/C31H32ClN9O3/c1-7-44-27-20(12-21(32)16(2)24(27)18-8-11-23(36-13-18)31(43)40(5)6)17(3)41-29-25(28(33)37-15-38-29)26(39-41)19-9-10-22(35-14-19)30(42)34-4/h8-15,17H,7H2,1-6H3,(H,34,42)(H2,33,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255865
PNG
(US9707233, 74 (1st peak))
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(CCO)C1)[C@@H](C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClF3N6O2/c1-9(30-20-14(16(28-30)18(23)24)19(25)26-8-27-20)11-5-12(21)15(22)13(17(11)32-2)10-6-29(7-10)3-4-31/h5,8-10,18,31H,3-4,6-7H2,1-2H3,(H2,25,26,27)/t9-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM256123
PNG
(5-(1-(4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H24F3N7O2/c1-10(33)6-31-7-13(8-31)15-17(23)12(5-26)4-14(19(15)34-3)11(2)32-22-16(18(30-32)20(24)25)21(27)28-9-29-22/h4,9-11,13,20,33H,6-8H2,1-3H3,(H2,27,28,29)/t10-,11?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 368 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%