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Patent code US9707233

Compile Data Set for Download or QSAR

Found 368 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110delta/p85alpha


(Homo sapiens (human))
BDBM255796
PNG
(1-{1-[5-Chloro-3-(1-isobutylazetidin-3-yl)-2-metho...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O/c1-12(2)8-29-9-16(10-29)19-13(3)18(24)7-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h7,11-12,15-16H,8-10H2,1-6H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255808
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255823
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255844
PNG
(5-{3-[1-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C2CC2)c2c(N)ncnc12
Show InChI InChI=1S/C27H30ClN7O2/c1-6-37-24-18(15(3)35-26-22(25(29)31-13-32-26)23(33-35)16-7-8-16)11-19(28)14(2)21(24)17-9-10-20(30-12-17)27(36)34(4)5/h9-13,15-16H,6-8H2,1-5H3,(H2,29,31,32)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM257687
PNG
(US9707233, 78)
Show SMILES COc1c(cc(C#N)c(F)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H24F3N7O2/c1-10(33)6-31-7-13(8-31)15-17(23)12(5-26)4-14(19(15)34-3)11(2)32-22-16(18(30-32)20(24)25)21(27)28-9-29-22/h4,9-11,13,20,33H,6-8H2,1-3H3,(H2,27,28,29)/t10-,11?/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261068
PNG
(3-{1-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(-c3cnc4[nH]ccc4c3)c3c(N)ncnc23)c1OCC
Show InChI InChI=1S/C26H27ClN8O2/c1-5-29-26(36)19-13(3)18(27)10-17(22(19)37-6-2)14(4)35-25-20(23(28)32-12-33-25)21(34-35)16-9-15-7-8-30-24(15)31-11-16/h7-12,14H,5-6H2,1-4H3,(H,29,36)(H,30,31)(H2,28,32,33)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261071
PNG
(1-{1-[5-Chloro-2-ethoxy-3-(1-isopropylazetidin-3-y...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O/c1-7-31-21-17(8-18(24)13(4)19(21)16-9-29(10-16)12(2)3)15(6)30-23-20(14(5)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261074
PNG
((2R)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O2/c1-6-32-21-17(15(5)30-23-20(14(4)28-30)22(25)26-11-27-23)7-18(24)13(3)19(21)16-9-29(10-16)8-12(2)31/h7,11-12,15-16,31H,6,8-10H2,1-5H3,(H2,25,26,27)/t12-,15?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261075
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H33ClN6O2/c1-7-33-21-17(15(4)31-23-20(14(3)29-31)22(26)27-12-28-23)8-18(25)13(2)19(21)16-9-30(10-16)11-24(5,6)32/h8,12,15-16,32H,7,9-11H2,1-6H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261078
PNG
(1-[1-(5-Chloro-2-ethoxy-4-methyl-3-{1-[(1-methyl-1...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H29ClN8O2/c1-6-36-22-18(15(4)34-24-21(14(3)31-34)23(27)28-12-29-24)7-19(26)13(2)20(22)17-10-33(11-17)25(35)16-8-30-32(5)9-16/h7-9,12,15,17H,6,10-11H2,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261082
PNG
((3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-11-16(22)7-15(19(30-4)17(11)14-8-28(9-14)6-5-23)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h7,10,13-14H,6,8-9H2,1-4H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261088
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(N)=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClN7O2/c1-10-15(22)5-14(19(31-4)17(10)13-6-28(7-13)8-16(23)30)12(3)29-21-18(11(2)27-29)20(24)25-9-26-21/h5,9,12-13H,6-8H2,1-4H3,(H2,23,30)(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261093
PNG
((2S)-3-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@H](O)C(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)8-16(33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)/t12?,16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261097
PNG
(1-[1-(5-Chloro-2-methoxy-4- methyl-3-{1-[(5-methyl...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnoc1C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O3/c1-11-18(25)6-16(13(3)32-23-20(12(2)30-32)22(26)27-10-28-23)21(34-5)19(11)15-8-31(9-15)24(33)17-7-29-35-14(17)4/h6-7,10,13,15H,8-9H2,1-5H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261105
PNG
(5-{1-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O/c1-11(2)31-8-15(9-31)17-12(3)14(7-26)6-16(20(17)33-5)13(4)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h6,10-11,13,15,21H,8-9H2,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261108
PNG
(5-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-15(9-31)17-12(2)14(6-26)5-16(20(17)34-4)13(3)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h5,10-11,13,15,21,33H,7-9H2,1-4H3,(H2,27,28,29)/t11-,13?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261137
PNG
((2S)-2-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)[C@@H](C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H32ClN7O2/c1-12-18(25)8-17(14(3)32-23-20(13(2)29-32)22(26)27-11-28-23)21(34-7)19(12)16-9-31(10-16)15(4)24(33)30(5)6/h8,11,14-16H,9-10H2,1-7H3,(H2,26,27,28)/t14?,15-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261148
PNG
(1-(1-(3-(6-aminopyridin-3-yl)-5- chloro-2-methoxy-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(N)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O/c1-10-15(22)7-14(19(30-4)17(10)13-5-6-16(23)25-8-13)12(3)29-21-18(11(2)28-29)20(24)26-9-27-21/h5-9,12H,1-4H3,(H2,23,25)(H2,24,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261162
PNG
(1-(1-(5-chloro-3-(6- (dimethylamino)pyridin-3-yl)-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O/c1-12-17(24)9-16(14(3)31-23-20(13(2)29-31)22(25)27-11-28-23)21(32-6)19(12)15-7-8-18(26-10-15)30(4)5/h7-11,14H,1-6H3,(H2,25,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261164
PNG
(1-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)N1CC(O)C1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C24H28ClN7O2/c1-12-19(25)6-18(14(3)31-24-21(13(2)26)23(27)29-11-30-24)22(34-4)20(12)15-5-16(8-28-7-15)32-9-17(33)10-32/h5-8,11,14,17,26,33H,9-10H2,1-4H3,(H3,27,29,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261167
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC1CC1
Show InChI InChI=1S/C27H32ClN7O2/c1-14-20(28)10-19(16(3)34-26-23(15(2)29)25(30)32-13-33-26)24(37-12-17-6-7-17)22(14)18-8-9-21(31-11-18)27(36)35(4)5/h8-11,13,16-17,29H,6-7,12H2,1-5H3,(H3,30,32,33,34)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261173
PNG
(5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-18(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)9-19(26)13(2)20(22)16-8-17(11-28-10-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261174
PNG
(1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(1-methyl-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-6-30-19-15(7-16(22)11(2)17(19)14-8-26-28(5)9-14)13(4)29-21-18(12(3)27-29)20(23)24-10-25-21/h7-10,13H,6H2,1-5H3,(H2,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261184
PNG
(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(c1)C(C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O2/c1-8-36-22-18(15(4)34-24-21(14(3)31-34)23(27)28-12-29-24)9-19(26)13(2)20(22)17-10-30-33(11-17)16(5)25(35)32(6)7/h9-12,15-16H,8H2,1-7H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261194
PNG
(US10092570, Example 217 | US9707233, 217)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O/c1-4-33-22-17(14(3)32-24-20(13(2)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-15-5-6-15/h7,12,14-16H,4-6,9-11H2,1-3H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261195
PNG
(US10092570, Example 218 | US9707233, 218)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C1CCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O/c1-4-33-22-17(14(3)32-24-20(13(2)30-32)23(27)28-12-29-24)8-19(25)18(9-26)21(22)15-10-31(11-15)16-6-5-7-16/h8,12,14-16H,4-7,10-11H2,1-3H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261207
PNG
(US9707233, 230)
Show SMILES CCOc1c(CC2CCOC2)c(C#N)c(Cl)cc1[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN6O2/c1-4-31-20-15(8-18(23)17(9-24)16(20)7-14-5-6-30-10-14)13(3)29-22-19(12(2)28-29)21(25)26-11-27-22/h8,11,13-14H,4-7,10H2,1-3H3,(H2,25,26,27)/t13-,14?/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261214
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN7O2/c1-6-34-21-16(14(3)32-23-19(13(2)30-32)22(27)28-12-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)24(4,5)11-33/h7,12,14-15,33H,6,9-11H2,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261215
PNG
(US9707233, 238)
Show SMILES CCOC(=O)C(C)(C)N1CC(C1)c1c(OCC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H32ClN7O3/c1-7-36-22-17(15(4)34-24-20(14(3)32-34)23(29)30-13-31-24)9-19(27)18(10-28)21(22)16-11-33(12-16)26(5,6)25(35)37-8-2/h9,13,15-16H,7-8,11-12H2,1-6H3,(H2,29,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261217
PNG
(US10092570, Example 240 | US9707233, 240)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)C(=O)NC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O2/c1-7-36-21-16(14(3)34-23-19(13(2)32-34)22(28)30-12-31-23)8-18(26)17(9-27)20(21)15-10-33(11-15)25(4,5)24(35)29-6/h8,12,14-15H,7,10-11H2,1-6H3,(H,29,35)(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261250
PNG
(S-4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimid...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(9-31)29-7-14(8-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11?,13-/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261256
PNG
(US9707233, 279)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CC2CCOC2)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O2/c1-13-20-23(27)28-12-29-24(20)32(30-13)14(2)17-6-19(25)18(7-26)21(22(17)33-3)16-9-31(10-16)8-15-4-5-34-11-15/h6,12,14-16H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t14-,15?/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261273
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-11-17-20(25)26-10-27-21(17)31(28-11)12(2)14-6-16(23)15(7-24)18(19(14)33-5)13-8-30(9-13)22(32)29(3)4/h6,10,12-13H,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261277
PNG
(US9707233, 300)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CCO)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H24Cl2N6O2/c1-10-15-19(23)24-9-25-20(15)28(26-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-27(8-12)4-5-29/h6,9,11-12,29H,4-5,7-8H2,1-3H3,(H2,23,24,25)/t11-/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261286
PNG
(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1cc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN6O2/c1-5-33-22-17(15(4)31-8-13(2)20-23(27)28-12-29-24(20)31)6-19(25)18(7-26)21(22)16-10-30(11-16)9-14(3)32/h6,8,12,14-16,32H,5,9-11H2,1-4H3,(H2,27,28,29)/t14-,15?/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261288
PNG
(US9707233, 314 (2nd peak))
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28N8O2/c1-7-36-23-18(16(4)34-25-21(15(3)32-34)24(28)30-13-31-25)10-14(2)19(11-27)22(23)17-8-9-20(29-12-17)26(35)33(5)6/h8-10,12-13,16H,7H2,1-6H3,(H2,28,30,31)/t16-/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261296
PNG
(US9707233, 322 (1st peak))
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(=O)C(C)(C)O)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31N7O3/c1-7-35-21-17(15(4)32-23-19(14(3)30-32)22(27)28-12-29-23)8-13(2)18(9-26)20(21)16-10-31(11-16)24(33)25(5,6)34/h8,12,15-16,34H,7,10-11H2,1-6H3,(H2,27,28,29)/t15-/m1/s1
PDB

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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261297
PNG
(US10092570, Example 326 | US9707233, 326)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O2/c1-6-33-22-18(16(5)31-24-20(15(4)29-31)23(26)27-12-28-24)7-13(2)19(8-25)21(22)17-10-30(11-17)9-14(3)32/h7,12,14,16-17,32H,6,9-11H2,1-5H3,(H2,26,27,28)/t14-,16?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261307
PNG
(US10092570, Example 336 | US9707233, 336)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)-c1nnn(C)n1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H22ClN11O/c1-5-37-21-15(13(3)36-24-19(12(2)32-36)22(27)29-11-30-24)8-17(25)16(9-26)20(21)14-6-7-18(28-10-14)23-31-34-35(4)33-23/h6-8,10-11,13H,5H2,1-4H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261308
PNG
(US10092570, Example 337 | US9707233, 337)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)-c1cnn(C)n1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H23ClN10O/c1-5-37-23-16(14(3)36-25-21(13(2)33-36)24(28)30-12-31-25)8-18(26)17(9-27)22(23)15-6-7-19(29-10-15)20-11-32-35(4)34-20/h6-8,10-12,14H,5H2,1-4H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261319
PNG
(US9707233, 323 (2nd peak))
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,14?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261329
PNG
(US10092570, Example 351 | US9707233, 349 | US97072...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12?/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255794
PNG
(1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-methylazeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H25ClN6O/c1-10-15(21)6-14(18(28-5)16(10)13-7-26(4)8-13)12(3)27-20-17(11(2)25-27)19(22)23-9-24-20/h6,9,12-13H,7-8H2,1-5H3,(H2,22,23,24)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255798
PNG
(1-(1-{5-Chloro-2-methoxy-3-[1-(2-methoxyethyl)azet...)
Show SMILES COCCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C22H29ClN6O2/c1-12-17(23)8-16(20(31-5)18(12)15-9-28(10-15)6-7-30-4)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h8,11,14-15H,6-7,9-10H2,1-5H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255805
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)11-18(26)13(2)20(22)16-8-9-28-19(10-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
PDB

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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255836
PNG
(5-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H24ClN7O3/c1-5-37-23-16(14(2)34-9-8-20(35)22-24(29)31-13-32-25(22)34)10-18(27)17(11-28)21(23)15-6-7-19(30-12-15)26(36)33(3)4/h6-10,12-14H,5H2,1-4H3,(H2,29,31,32)
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UniChem
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255853
PNG
(5-{3-[1-(4-amino-3-{5-[(dimethylamino)carbonyl]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cncc(c2)C(=O)N(C)C)c2c(N)ncnc12
Show InChI InChI=1S/C32H34ClN9O3/c1-8-45-28-22(12-23(33)17(2)25(28)19-9-10-24(36-15-19)32(44)41(6)7)18(3)42-30-26(29(34)37-16-38-30)27(39-42)20-11-21(14-35-13-20)31(43)40(4)5/h9-16,18H,8H2,1-7H3,(H2,34,37,38)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%