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Patent code US9708253

Compile Data Set for Download or QSAR
Found 135 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261363
PNG
(US9708253, 21 | US9708253, 22)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)CC#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C31H25F9N2O4S/c32-21-8-10-23(11-9-21)47(44,45)28(15-12-22(13-16-28)42-27(43)14-17-41)19-4-6-20(7-5-19)29(30(35,36)37,31(38,39)40)46-18-24-25(33)2-1-3-26(24)34/h1-11,22H,12-16,18H2,(H,42,43)/t22-,28+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261360
PNG
(US9708253, 18)
Show SMILES CC(=O)NC1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H26F9NO4S/c1-18(41)40-22-13-15-27(16-14-22,45(42,43)23-11-9-21(31)10-12-23)19-5-7-20(8-6-19)28(29(34,35)36,30(37,38)39)44-17-24-25(32)3-2-4-26(24)33/h2-12,22H,13-17H2,1H3,(H,40,41)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261381
PNG
(US9708253, 39)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)Cc1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C35H29F9N2O4S/c36-25-10-12-27(13-11-25)51(48,49)32(16-14-26(15-17-32)46-31(47)19-22-3-2-18-45-20-22)23-6-8-24(9-7-23)33(34(39,40)41,35(42,43)44)50-21-28-29(37)4-1-5-30(28)38/h1-13,18,20,26H,14-17,19,21H2,(H,46,47)/t26-,32+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261402
PNG
(US9708253, 60)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)N1CCOCC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H26F8N2O4S/c27-19-5-7-21(8-6-19)41(38,39)23(11-9-20(10-12-23)35-22(37)36-13-15-40-16-14-36)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,20H,9-16H2,(H,35,37)/t20-,23+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261378
PNG
(US9708253, 36)
Show SMILES CC1(C)CC(CCO1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H36F9NO5S/c1-32(2)20-22(16-19-50-32)31(47)46-26-14-17-33(18-15-26,52(48,49)27-12-10-25(37)11-13-27)23-6-8-24(9-7-23)34(35(40,41)42,36(43,44)45)51-21-28-29(38)4-3-5-30(28)39/h3-13,22,26H,14-21H2,1-2H3,(H,46,47)/t22?,26-,33+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261376
PNG
(US9708253, 34 | US9708253, 35)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H32F9NO5S/c35-24-8-10-26(11-9-24)50(46,47)31(16-12-25(13-17-31)44-30(45)21-14-18-48-19-15-21)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,21,25H,12-20H2,(H,44,45)/t25-,31+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261389
PNG
(US9708253, 47 | US9708253, 48)
Show SMILES CS(=O)(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H26F9NO5S2/c1-45(40,41)39-21-13-15-26(16-14-21,46(42,43)22-11-9-20(30)10-12-22)18-5-7-19(8-6-18)27(28(33,34)35,29(36,37)38)44-17-23-24(31)3-2-4-25(23)32/h2-12,21,39H,13-17H2,1H3/t21-,26+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261379
PNG
(US9708253, 37)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H27F9N2O4S/c35-24-10-12-26(13-11-24)50(47,48)31(16-14-25(15-17-31)45-30(46)21-3-2-18-44-19-21)22-6-8-23(9-7-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)4-1-5-29(27)37/h1-13,18-19,25H,14-17,20H2,(H,45,46)/t25-,31+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261447
PNG
(US9708253, 106)
Show SMILES OCC(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H21F8NO4S/c24-16-5-7-18(8-6-16)37(35,36)20(11-9-17(10-12-20)32-19(34)13-33)14-1-3-15(4-2-14)21(25,22(26,27)28)23(29,30)31/h1-8,17,33H,9-13H2,(H,32,34)/t17-,20+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261375
PNG
(US9708253, 33)
Show SMILES CN1CCC(CC1=O)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C35H33F9N2O5S/c1-46-18-15-21(19-30(46)47)31(48)45-25-13-16-32(17-14-25,52(49,50)26-11-9-24(36)10-12-26)22-5-7-23(8-6-22)33(34(39,40)41,35(42,43)44)51-20-27-28(37)3-2-4-29(27)38/h2-12,21,25H,13-20H2,1H3,(H,45,48)/t21?,25-,32+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261354
PNG
(US9708253, 12)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)OCc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H28F9NO4S/c35-25-8-10-27(11-9-25)49(45,46)31(16-12-26(13-17-31)47-20-22-14-18-44-19-15-22)23-4-6-24(7-5-23)32(33(38,39)40,34(41,42)43)48-21-28-29(36)2-1-3-30(28)37/h1-11,14-15,18-19,26H,12-13,16-17,20-21H2
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261388
PNG
(US9708253, 46)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)N1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C33H31F9N2O5S/c34-23-8-10-25(11-9-23)50(46,47)30(14-12-24(13-15-30)43-29(45)44-16-18-48-19-17-44)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)49-20-26-27(35)2-1-3-28(26)36/h1-11,24H,12-20H2,(H,43,45)/t24-,30+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261401
PNG
(US9708253, 59)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)Cc1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H24F8N2O3S/c29-21-5-7-23(8-6-21)42(40,41)25(13-9-22(10-14-25)38-24(39)17-18-11-15-37-16-12-18)19-1-3-20(4-2-19)26(30,27(31,32)33)28(34,35)36/h1-8,11-12,15-16,22H,9-10,13-14,17H2,(H,38,39)/t22-,25+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261474
PNG
(US9708253, 133)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NCC1CCS(=O)(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H29F8NO5S2/c29-22-5-7-23(8-6-22)44(41,42)25(20-1-3-21(4-2-20)26(30,27(31,32)33)28(34,35)36)13-9-19(10-14-25)24(38)37-17-18-11-15-43(39,40)16-12-18/h1-8,18-19H,9-17H2,(H,37,38)
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261380
PNG
(US9708253, 38 | US9708253, 40)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)Cc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C35H29F9N2O4S/c36-25-8-10-27(11-9-25)51(48,49)32(16-12-26(13-17-32)46-31(47)20-22-14-18-45-19-15-22)23-4-6-24(7-5-23)33(34(39,40)41,35(42,43)44)50-21-28-29(37)2-1-3-30(28)38/h1-11,14-15,18-19,26H,12-13,16-17,20-21H2,(H,46,47)/t26-,32+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261475
PNG
(US9708253, 134)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NC1(CC1)c1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H26F8N2O3S/c31-23-5-7-24(8-6-23)44(42,43)27(21-1-3-22(4-2-21)28(32,29(33,34)35)30(36,37)38)13-9-19(10-14-27)25(41)40-26(15-16-26)20-11-17-39-18-12-20/h1-8,11-12,17-19H,9-10,13-16H2,(H,40,41)
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261439
PNG
(US9708253, 98)
Show SMILES OC(c1ccc(cc1)[C@]1(CC[C@@H](CC1)NC(=O)Cc1ccncc1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H25F7N2O4S/c29-21-5-7-23(8-6-21)42(40,41)25(13-9-22(10-14-25)37-24(38)17-18-11-15-36-16-12-18)19-1-3-20(4-2-19)26(39,27(30,31)32)28(33,34)35/h1-8,11-12,15-16,22,39H,9-10,13-14,17H2,(H,37,38)/t22-,25+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261365
PNG
(US9708253, 23)
Show SMILES CC(C)(C#N)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C33H29F9N2O4S/c1-29(2,19-43)28(45)44-23-14-16-30(17-15-23,49(46,47)24-12-10-22(34)11-13-24)20-6-8-21(9-7-20)31(32(37,38)39,33(40,41)42)48-18-25-26(35)4-3-5-27(25)36/h3-13,23H,14-18H2,1-2H3,(H,44,45)/t23-,30+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261385
PNG
(US9708253, 43 | US9708253, 44)
Show SMILES COC(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H26F9NO5S/c1-44-26(41)40-21-13-15-27(16-14-21,46(42,43)22-11-9-20(31)10-12-22)18-5-7-19(8-6-18)28(29(34,35)36,30(37,38)39)45-17-23-24(32)3-2-4-25(23)33/h2-12,21H,13-17H2,1H3,(H,40,41)/t21-,27+
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Bristol-Myers Squibb Company

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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261444
PNG
(US9708253, 103)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1ccnnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H21F8N3O3S/c27-19-5-7-21(8-6-19)41(39,40)23(12-9-20(10-13-23)37-22(38)16-11-14-35-36-15-16)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,11,14-15,20H,9-10,12-13H2,(H,37,38)/t20-,23+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261405
PNG
(US9708253, 63)
Show SMILES CCn1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H25F9N2O3S/c1-2-42-27-14-15-28(16-19(27)17-41-42,46(43,44)23-12-10-22(32)11-13-23)20-6-8-21(9-7-20)29(30(35,36)37,31(38,39)40)45-18-24-25(33)4-3-5-26(24)34/h3-13,17H,2,14-16,18H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261395
PNG
(US9708253, 53)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H22F8N2O3S/c28-20-5-7-22(8-6-20)41(39,40)24(13-9-21(10-14-24)37-23(38)17-11-15-36-16-12-17)18-1-3-19(4-2-18)25(29,26(30,31)32)27(33,34)35/h1-8,11-12,15-16,21H,9-10,13-14H2,(H,37,38)/t21-,24+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261443
PNG
(US9708253, 102 | US9708253, 108)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NCc1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H24F8N2O3S/c29-22-5-7-23(8-6-22)42(40,41)25(13-9-19(10-14-25)24(39)38-17-18-11-15-37-16-12-18)20-1-3-21(4-2-20)26(30,27(31,32)33)28(34,35)36/h1-8,11-12,15-16,19H,9-10,13-14,17H2,(H,38,39)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261471
PNG
(US9708253, 130)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NCC1CCOCC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H29F8NO4S/c29-22-5-7-23(8-6-22)42(39,40)25(13-9-19(10-14-25)24(38)37-17-18-11-15-41-16-12-18)20-1-3-21(4-2-20)26(30,27(31,32)33)28(34,35)36/h1-8,18-19H,9-17H2,(H,37,38)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261453
PNG
(4-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perflu...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)N1CCOCC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H25F8NO3S/c26-19-5-7-21(8-6-19)38(35,36)22(11-9-20(10-12-22)34-13-15-37-16-14-34)17-1-3-18(4-2-17)23(27,24(28,29)30)25(31,32)33/h1-8,20H,9-16H2/t20-,22+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261438
PNG
(US9708253, 97)
Show SMILES OC(c1ccc(cc1)[C@]1(CC[C@@H](CC1)NC(=O)c1cccnc1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H23F7N2O4S/c28-20-7-9-22(10-8-20)41(39,40)24(13-11-21(12-14-24)36-23(37)17-2-1-15-35-16-17)18-3-5-19(6-4-18)25(38,26(29,30)31)27(32,33)34/h1-10,15-16,21,38H,11-14H2,(H,36,37)/t21-,24+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261347
PNG
((1r,4r)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,...)
Show SMILES O[C@H]1CC[C@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H23F9O4S/c29-19-8-10-21(11-9-19)42(39,40)25(14-12-20(38)13-15-25)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)41-16-22-23(30)2-1-3-24(22)31/h1-11,20,38H,12-16H2/t20-,25-
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261465
PNG
(4-(4-fluorophenylsulfonyl)-4-(4-(perfluoropropan-2...)
Show SMILES COC(=O)C1CCC(CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H20F8O4S/c1-35-19(32)14-10-12-20(13-11-14,36(33,34)18-8-6-17(24)7-9-18)15-2-4-16(5-3-15)21(25,22(26,27)28)23(29,30)31/h2-9,14H,10-13H2,1H3
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261372
PNG
(US9708253, 30)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)C1CCC(F)(F)CC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C35H32F11NO4S/c36-24-8-10-26(11-9-24)52(49,50)31(16-14-25(15-17-31)47-30(48)21-12-18-32(39,40)19-13-21)22-4-6-23(7-5-22)33(34(41,42)43,35(44,45)46)51-20-27-28(37)2-1-3-29(27)38/h1-11,21,25H,12-20H2,(H,47,48)/t25-,31+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261454
PNG
(4-((1s,4s)-4-((4-fluorophenyl)sulfonyl)-4-(4-(perf...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)N1CCS(=O)(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H25F8NO4S2/c26-19-5-7-21(8-6-19)40(37,38)22(11-9-20(10-12-22)34-13-15-39(35,36)16-14-34)17-1-3-18(4-2-17)23(27,24(28,29)30)25(31,32)33/h1-8,20H,9-16H2/t20-,22+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261366
PNG
(US9708253, 24)
Show SMILES OC1(CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C32H28F9NO5S/c33-21-8-10-23(11-9-21)48(45,46)29(14-12-22(13-15-29)42-27(43)28(44)16-17-28)19-4-6-20(7-5-19)30(31(36,37)38,32(39,40)41)47-18-24-25(34)2-1-3-26(24)35/h1-11,22,44H,12-18H2,(H,42,43)/t22-,29+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261468
PNG
(US9708253, 127)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NCc1ccnnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H23F8N3O3S/c28-21-5-7-22(8-6-21)42(40,41)24(12-9-18(10-13-24)23(39)36-15-17-11-14-37-38-16-17)19-1-3-20(4-2-19)25(29,26(30,31)32)27(33,34)35/h1-8,11,14,16,18H,9-10,12-13,15H2,(H,36,39)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261448
PNG
(US9708253, 107)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)Cc1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H24F8N2O3S/c29-21-7-9-23(10-8-21)42(40,41)25(13-11-22(12-14-25)38-24(39)16-18-2-1-15-37-17-18)19-3-5-20(6-4-19)26(30,27(31,32)33)28(34,35)36/h1-10,15,17,22H,11-14,16H2,(H,38,39)/t22-,25+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261400
PNG
(US9708253, 58)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1cncnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H21F8N3O3S/c27-19-5-7-21(8-6-19)41(39,40)23(11-9-20(10-12-23)37-22(38)16-13-35-15-36-14-16)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,13-15,20H,9-12H2,(H,37,38)/t20-,23+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261455
PNG
(4-(1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(per...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)N=[N+]=[N-])c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H17F8N3O2S/c22-15-5-7-17(8-6-15)35(33,34)18(11-9-16(10-12-18)31-32-30)13-1-3-14(4-2-13)19(23,20(24,25)26)21(27,28)29/h1-8,16H,9-12H2/t16-,18+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261327
PNG
(2-(4-((1r,4r)-4-amino-1-((4-fluorophenyl)sulfonyl)...)
Show SMILES ON=C1CCC(CC1)(c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H24F7NO4S/c29-22-10-12-24(13-11-22)41(38,39)25(16-14-23(36-37)15-17-25)20-6-8-21(9-7-20)26(27(30,31)32,28(33,34)35)40-18-19-4-2-1-3-5-19/h1-13,37H,14-18H2/b36-23-
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261392
PNG
(US9708253, 50)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)CC#N)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C24H20F8N2O3S/c25-17-5-7-19(8-6-17)38(36,37)21(12-9-18(10-13-21)34-20(35)11-14-33)15-1-3-16(4-2-15)22(26,23(27,28)29)24(30,31)32/h1-8,18H,9-13H2,(H,34,35)/t18-,21+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261396
PNG
(US9708253, 54)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H22F8N2O3S/c28-20-7-9-22(10-8-20)41(39,40)24(13-11-21(12-14-24)37-23(38)17-2-1-15-36-16-17)18-3-5-19(6-4-18)25(29,26(30,31)32)27(33,34)35/h1-10,15-16,21H,11-14H2,(H,37,38)/t21-,24+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261456
PNG
(US9708253, 115)
Show SMILES CCOC(=O)c1cn(nn1)[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H23F8N3O4S/c1-2-41-22(38)21-15-37(36-35-21)19-11-13-23(14-12-19,42(39,40)20-9-7-18(27)8-10-20)16-3-5-17(6-4-16)24(28,25(29,30)31)26(32,33)34/h3-10,15,19H,2,11-14H2,1H3/t19-,23+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261470
PNG
(US9708253, 129)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)N1CCC(C1)c1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C31H28F8N2O3S/c32-25-5-7-26(8-6-25)45(43,44)28(23-1-3-24(4-2-23)29(33,30(34,35)36)31(37,38)39)14-9-21(10-15-28)27(42)41-18-13-22(19-41)20-11-16-40-17-12-20/h1-8,11-12,16-17,21-22H,9-10,13-15,18-19H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261368
PNG
(US9708253, 26)
Show SMILES CN1CC(CC1=O)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C34H31F9N2O5S/c1-45-18-20(17-29(45)46)30(47)44-24-13-15-31(16-14-24,51(48,49)25-11-9-23(35)10-12-25)21-5-7-22(8-6-21)32(33(38,39)40,34(41,42)43)50-19-26-27(36)3-2-4-28(26)37/h2-12,20,24H,13-19H2,1H3,(H,44,47)/t20?,24-,31+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261350
PNG
(4-((1s,4s)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)N1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C32H30F9NO4S/c33-23-8-10-25(11-9-23)47(43,44)29(14-12-24(13-15-29)42-16-18-45-19-17-42)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)46-20-26-27(34)2-1-3-28(26)35/h1-11,24H,12-20H2/t24-,29+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261361
PNG
(US9708253, 19 | US9708253, 20)
Show SMILES CC(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H26F9NO4S/c1-18(41)40-22-13-15-27(16-14-22,45(42,43)23-11-9-21(31)10-12-23)19-5-7-20(8-6-19)28(29(34,35)36,30(37,38)39)44-17-24-25(32)3-2-4-26(24)33/h2-12,22H,13-17H2,1H3,(H,40,41)/t22-,27+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261367
PNG
(US9708253, 25)
Show SMILES CC(=O)N1CC(C1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C34H31F9N2O5S/c1-20(46)45-17-21(18-45)30(47)44-25-13-15-31(16-14-25,51(48,49)26-11-9-24(35)10-12-26)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)50-19-27-28(36)3-2-4-29(27)37/h2-12,21,25H,13-19H2,1H3,(H,44,47)/t25-,31+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261409
PNG
(US9708253, 67)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCc2nn(Cc3ccncc3)cc2C1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C35H26F9N3O3S/c36-26-8-10-27(11-9-26)51(48,49)32(15-12-31-23(18-32)20-47(46-31)19-22-13-16-45-17-14-22)24-4-6-25(7-5-24)33(34(39,40)41,35(42,43)44)50-21-28-29(37)2-1-3-30(28)38/h1-11,13-14,16-17,20H,12,15,18-19,21H2
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261424
PNG
(1-(4-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,...)
Show SMILES CC(=O)N1CCN(CC1)C1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C34H33F9N2O4S/c1-22(46)44-17-19-45(20-18-44)26-13-15-31(16-14-26,50(47,48)27-11-9-25(35)10-12-27)23-5-7-24(8-6-23)32(33(38,39)40,34(41,42)43)49-21-28-29(36)3-2-4-30(28)37/h2-12,26H,13-21H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261466
PNG
(US9708253, 125)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)Nc1ccnnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H21F8N3O3S/c27-19-5-7-21(8-6-19)41(39,40)23(12-9-16(10-13-23)22(38)37-20-11-14-35-36-15-20)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,11,14-16H,9-10,12-13H2,(H,35,37,38)
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261473
PNG
(US9708253, 132)
Show InChI InChI=1S/C28H27F8N3O3S/c1-16-23(17(2)39-38-16)15-37-24(40)18-11-13-25(14-12-18,43(41,42)22-9-7-21(29)8-10-22)19-3-5-20(6-4-19)26(30,27(31,32)33)28(34,35)36/h3-10,18H,11-15H2,1-2H3,(H,37,40)(H,38,39)
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261451
PNG
(US9708253, 110)
Show SMILES CC1(CCC(CC1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)NC(=O)Cc1ccncc1
Show InChI InChI=1S/C29H27F7N2O4S/c1-25(38-24(39)18-19-10-16-37-17-11-19)12-14-26(15-13-25,43(41,42)23-8-6-22(30)7-9-23)20-2-4-21(5-3-20)27(40,28(31,32)33)29(34,35)36/h2-11,16-17,40H,12-15,18H2,1H3,(H,38,39)
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261393
PNG
(US9708253, 51)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H30F8N2O4S/c1-18(40)39-16-12-19(13-17-39)25(41)38-23-10-14-26(15-11-23,44(42,43)24-8-6-22(30)7-9-24)20-2-4-21(5-3-20)27(31,28(32,33)34)29(35,36)37/h2-9,19,23H,10-17H2,1H3,(H,38,41)/t23-,26+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261445
PNG
(US9708253, 104)
Show SMILES Cc1cc(ccn1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H24F8N2O3S/c1-17-16-18(12-15-37-17)24(39)38-22-10-13-25(14-11-22,42(40,41)23-8-6-21(29)7-9-23)19-2-4-20(5-3-19)26(30,27(31,32)33)28(34,35)36/h2-9,12,15-16,22H,10-11,13-14H2,1H3,(H,38,39)/t22-,25+
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Bristol-Myers Squibb Company

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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261369
PNG
(US9708253, 27 | US9708253, 28)
Show SMILES OC1CCC(CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C35H34F9NO5S/c36-24-10-14-27(15-11-24)51(48,49)32(18-16-25(17-19-32)45-31(47)21-4-12-26(46)13-5-21)22-6-8-23(9-7-22)33(34(39,40)41,35(42,43)44)50-20-28-29(37)2-1-3-30(28)38/h1-3,6-11,14-15,21,25-26,46H,4-5,12-13,16-20H2,(H,45,47)/t21?,25-,26?,32+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261371
PNG
(US9708253, 29)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H34F9NO6S/c37-25-12-14-27(15-13-25)53(50,51)33(18-16-26(17-19-33)46-31(47)21-4-6-22(7-5-21)32(48)49)23-8-10-24(11-9-23)34(35(40,41)42,36(43,44)45)52-20-28-29(38)2-1-3-30(28)39/h1-3,8-15,21-22,26H,4-7,16-20H2,(H,46,47)(H,48,49)/t21-,22-,26-,33+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261373
PNG
(US9708253, 31 | US9708253, 32)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H35F9N2O5S/c1-22(48)47-19-15-23(16-20-47)32(49)46-27-13-17-33(18-14-27,53(50,51)28-11-9-26(37)10-12-28)24-5-7-25(8-6-24)34(35(40,41)42,36(43,44)45)52-21-29-30(38)3-2-4-31(29)39/h2-12,23,27H,13-21H2,1H3,(H,46,49)/t27-,33+
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261349
PNG
(N-((1s,4s)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1...)
Show SMILES ON=C1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H22F9NO4S/c29-19-8-10-21(11-9-19)43(40,41)25(14-12-20(38-39)13-15-25)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)42-16-22-23(30)2-1-3-24(22)31/h1-11,39H,12-16H2/b38-20-
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261391
PNG
(US9708253, 49)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)N1CCCC1=O)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C32H28F9NO4S/c33-22-10-12-24(13-11-22)47(44,45)29(16-14-23(15-17-29)42-18-2-5-28(42)43)20-6-8-21(9-7-20)30(31(36,37)38,32(39,40)41)46-19-25-26(34)3-1-4-27(25)35/h1,3-4,6-13,23H,2,5,14-19H2/t23-,29+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261477
PNG
(US9708253, 136)
Show InChI InChI=1S/C29H26F8N2O3S/c30-23-5-7-24(8-6-23)43(41,42)26(21-1-3-22(4-2-21)27(31,28(32,33)34)29(35,36)37)14-9-20(10-15-26)25(40)39-18-13-19-11-16-38-17-12-19/h1-8,11-12,16-17,20H,9-10,13-15,18H2,(H,39,40)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261399
PNG
(US9708253, 57)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1cnccn1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H21F8N3O3S/c27-18-5-7-20(8-6-18)41(39,40)23(11-9-19(10-12-23)37-22(38)21-15-35-13-14-36-21)16-1-3-17(4-2-16)24(28,25(29,30)31)26(32,33)34/h1-8,13-15,19H,9-12H2,(H,37,38)/t19-,23+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261394
PNG
(US9708253, 52)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)C1CCN(CC1)C(=O)CC#N)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H29F8N3O4S/c31-22-5-7-24(8-6-22)46(44,45)27(20-1-3-21(4-2-20)28(32,29(33,34)35)30(36,37)38)14-9-23(10-15-27)40-26(43)19-12-17-41(18-13-19)25(42)11-16-39/h1-8,19,23H,9-15,17-18H2,(H,40,43)/t23-,27+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261369
PNG
(US9708253, 27 | US9708253, 28)
Show SMILES OC1CCC(CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C35H34F9NO5S/c36-24-10-14-27(15-11-24)51(48,49)32(18-16-25(17-19-32)45-31(47)21-4-12-26(46)13-5-21)22-6-8-23(9-7-22)33(34(39,40)41,35(42,43)44)50-20-28-29(37)2-1-3-30(28)38/h1-3,6-11,14-15,21,25-26,46H,4-5,12-13,16-20H2,(H,45,47)/t21?,25-,26?,32+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261351
PNG
(N-((1s,4s)-4-((4-fluorophenyl)sulfonyl)-4-(4-(perf...)
Show SMILES NC1CCC(CC1)(c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H26F7NO3S/c29-22-10-12-24(13-11-22)40(37,38)25(16-14-23(36)15-17-25)20-6-8-21(9-7-20)26(27(30,31)32,28(33,34)35)39-18-19-4-2-1-3-5-19/h1-13,23H,14-18,36H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261433
PNG
(4-((4-fluorophenyl)sulfonyl)-4-(4-(1,1,1,3,3,3-hex...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C#N)c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H24F7NO3S/c30-24-10-12-25(13-11-24)41(38,39)26(16-14-20(18-37)15-17-26)22-6-8-23(9-7-22)27(28(31,32)33,29(34,35)36)40-19-21-4-2-1-3-5-21/h1-13,20H,14-17,19H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261476
PNG
(US9708253, 135)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NCc1cn[nH]c1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H23F8N3O3S/c27-20-5-7-21(8-6-20)41(39,40)23(11-9-17(10-12-23)22(38)35-13-16-14-36-37-15-16)18-1-3-19(4-2-18)24(28,25(29,30)31)26(32,33)34/h1-8,14-15,17H,9-13H2,(H,35,38)(H,36,37)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261467
PNG
(US9708253, 126)
Show SMILES CC1(O)CCN(CC1)C(=O)C1CCC(CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H29F8NO4S/c1-24(39)14-16-37(17-15-24)23(38)18-10-12-25(13-11-18,42(40,41)22-8-6-21(29)7-9-22)19-2-4-20(5-3-19)26(30,27(31,32)33)28(34,35)36/h2-9,18,39H,10-17H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261346
PNG
((1s,4s)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,...)
Show SMILES O[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H23F9O4S/c29-19-8-10-21(11-9-19)42(39,40)25(14-12-20(38)13-15-25)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)41-16-22-23(30)2-1-3-24(22)31/h1-11,20,38H,12-16H2/t20-,25+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261359
PNG
(US9708253, 17)
Show SMILES CN(C)[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H28F9NO3S/c1-40(2)22-14-16-27(17-15-22,44(41,42)23-12-10-21(31)11-13-23)19-6-8-20(9-7-19)28(29(34,35)36,30(37,38)39)43-18-24-25(32)4-3-5-26(24)33/h3-13,22H,14-18H2,1-2H3/t22-,27+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261384
PNG
(US9708253, 42)
Show SMILES Cn1cc(cn1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C33H28F9N3O4S/c1-45-18-20(17-43-45)29(46)44-24-13-15-30(16-14-24,50(47,48)25-11-9-23(34)10-12-25)21-5-7-22(8-6-21)31(32(37,38)39,33(40,41)42)49-19-26-27(35)3-2-4-28(26)36/h2-12,17-18,24H,13-16,19H2,1H3,(H,44,46)/t24-,30+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261410
PNG
(US9708253, 68)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCc2c(C1)cnn2Cc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C35H26F9N3O3S/c36-26-8-10-27(11-9-26)51(48,49)32(15-12-31-23(18-32)19-46-47(31)20-22-13-16-45-17-14-22)24-4-6-25(7-5-24)33(34(39,40)41,35(42,43)44)50-21-28-29(37)2-1-3-30(28)38/h1-11,13-14,16-17,19H,12,15,18,20-21H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261414
PNG
(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexa...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCc2nn(cc2C1)-c1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H24F9N3O3S/c35-24-8-10-26(11-9-24)50(47,48)31(15-12-30-21(18-31)19-46(45-30)25-13-16-44-17-14-25)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,13-14,16-17,19H,12,15,18,20H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261460
PNG
((1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perfl...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C(=O)N1CCOCC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H26F8N4O4S/c29-20-5-7-22(8-6-20)45(42,43)25(18-1-3-19(4-2-18)26(30,27(31,32)33)28(34,35)36)11-9-21(10-12-25)40-17-23(37-38-40)24(41)39-13-15-44-16-14-39/h1-8,17,21H,9-16H2/t21-,25+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261464
PNG
(N-((2R,4R)-4-(4-fluorophenylsulfonyl)-2-methyl-4-(...)
Show SMILES C[C@@H]1C[C@](CCC1NC(=O)Cc1ccncc1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H26F8N2O3S/c1-18-17-26(43(41,42)23-8-6-22(30)7-9-23,13-10-24(18)39-25(40)16-19-11-14-38-15-12-19)20-2-4-21(5-3-20)27(31,28(32,33)34)29(35,36)37/h2-9,11-12,14-15,18,24H,10,13,16-17H2,1H3,(H,39,40)/t18-,24?,26-/m1/s1
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261427
PNG
(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)C1CCC(CC1)n1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H31F9N2O5S/c37-25-10-14-27(15-11-25)53(50,51)33(17-16-31-22(18-33)19-47(46-31)26-12-4-21(5-13-26)32(48)49)23-6-8-24(9-7-23)34(35(40,41)42,36(43,44)45)52-20-28-29(38)2-1-3-30(28)39/h1-3,6-11,14-15,19,21,26H,4-5,12-13,16-18,20H2,(H,48,49)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261440
PNG
(US9708253, 99)
Show SMILES CC(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F7NO4S/c1-14(32)31-18-10-12-20(13-11-18,36(34,35)19-8-6-17(24)7-9-19)15-2-4-16(5-3-15)21(33,22(25,26)27)23(28,29)30/h2-9,18,33H,10-13H2,1H3,(H,31,32)/t18-,20+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261421
PNG
(3-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES CCOC(=O)CCn1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C34H29F9N2O5S/c1-2-49-30(46)15-17-45-29-14-16-31(18-21(29)19-44-45,51(47,48)25-12-10-24(35)11-13-25)22-6-8-23(9-7-22)32(33(38,39)40,34(41,42)43)50-20-26-27(36)4-3-5-28(26)37/h3-13,19H,2,14-18,20H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261450
PNG
(US9708253, 109)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NS(=O)(=O)c1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H22F8N2O4S2/c27-19-7-9-21(10-8-19)41(37,38)23(13-11-20(12-14-23)36-42(39,40)22-2-1-15-35-16-22)17-3-5-18(6-4-17)24(28,25(29,30)31)26(32,33)34/h1-10,15-16,20,36H,11-14H2/t20-,23+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261425
PNG
(1-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show InChI InChI=1S/C33H33F9N2O3S/c1-43-17-19-44(20-18-43)25-13-15-30(16-14-25,48(45,46)26-11-9-24(34)10-12-26)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)47-21-27-28(35)3-2-4-29(27)36/h2-12,25H,13-21H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261398
PNG
(US9708253, 56)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1ccncn1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H21F8N3O3S/c27-18-5-7-20(8-6-18)41(39,40)23(12-9-19(10-13-23)37-22(38)21-11-14-35-15-36-21)16-1-3-17(4-2-16)24(28,25(29,30)31)26(32,33)34/h1-8,11,14-15,19H,9-10,12-13H2,(H,37,38)/t19-,23+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261397
PNG
(US9708253, 55)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1cccnn1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H21F8N3O3S/c27-18-7-9-20(10-8-18)41(39,40)23(13-11-19(12-14-23)36-22(38)21-2-1-15-35-37-21)16-3-5-17(6-4-16)24(28,25(29,30)31)26(32,33)34/h1-10,15,19H,11-14H2,(H,36,38)/t19-,23+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261345
PNG
(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexa...)
Show SMILES CC(C)(C)OC(=O)C1CC(CCC1=O)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C33H29F9O6S/c1-29(2,3)48-28(44)23-17-30(16-15-27(23)43,49(45,46)22-13-11-21(34)12-14-22)19-7-9-20(10-8-19)31(32(37,38)39,33(40,41)42)47-18-24-25(35)5-4-6-26(24)36/h4-14,23H,15-18H2,1-3H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261432
PNG
(1-benzyl-4-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)N1CCN(Cc2ccccc2)CC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C39H37F9N2O3S/c40-30-13-15-32(16-14-30)54(51,52)36(19-17-31(18-20-36)50-23-21-49(22-24-50)25-27-5-2-1-3-6-27)28-9-11-29(12-10-28)37(38(43,44)45,39(46,47)48)53-26-33-34(41)7-4-8-35(33)42/h1-16,31H,17-26H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261436
PNG
(N-(4-((4-fluorophenyl)sulfonyl)-1-methyl-4-(4-(per...)
Show SMILES CC(C)(C)OC(=O)NC1(C)CCC(CC1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H30F7NO5S/c1-22(2,3)40-21(36)35-23(4)13-15-24(16-14-23,41(38,39)20-11-9-19(28)10-12-20)17-5-7-18(8-6-17)25(37,26(29,30)31)27(32,33)34/h5-12,37H,13-16H2,1-4H3,(H,35,36)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261462
PNG
(1-(3-(1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C1CNC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H24F8N4O2S/c27-19-5-7-21(8-6-19)41(39,40)23(11-9-20(10-12-23)38-15-22(36-37-38)16-13-35-14-16)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,15-16,20,35H,9-14H2/t20-,23+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261411
PNG
(US9708253, 69 | US9708253, 70)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCc2c(C1)cnn2C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H29F9N2O4S/c35-24-8-10-26(11-9-24)50(46,47)31(15-12-30-21(18-31)19-44-45(30)25-13-16-48-17-14-25)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,19,25H,12-18,20H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261352
PNG
(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexa...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(=O)C(C1)C=O)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H21F9O5S/c30-20-8-10-21(11-9-20)44(41,42)26(13-12-25(40)17(14-26)15-39)18-4-6-19(7-5-18)27(28(33,34)35,29(36,37)38)43-16-22-23(31)2-1-3-24(22)32/h1-11,15,17H,12-14,16H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261427
PNG
(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)C1CCC(CC1)n1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H31F9N2O5S/c37-25-10-14-27(15-11-25)53(50,51)33(17-16-31-22(18-33)19-47(46-31)26-12-4-21(5-13-26)32(48)49)23-6-8-24(9-7-23)34(35(40,41)42,36(43,44)45)52-20-28-29(38)2-1-3-30(28)39/h1-3,6-11,14-15,19,21,26H,4-5,12-13,16-18,20H2,(H,48,49)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261422
PNG
(3-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)CCn1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C32H25F9N2O5S/c33-22-8-10-23(11-9-22)49(46,47)29(14-12-27-19(16-29)17-42-43(27)15-13-28(44)45)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)48-18-24-25(34)2-1-3-26(24)35/h1-11,17H,12-16,18H2,(H,44,45)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261356
PNG
(US9708253, 14)
Show SMILES COC(=O)OC1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H25F9O6S/c1-43-26(40)45-21-13-15-27(16-14-21,46(41,42)22-11-9-20(31)10-12-22)18-5-7-19(8-6-18)28(29(34,35)36,30(37,38)39)44-17-23-24(32)3-2-4-25(23)33/h2-12,21H,13-17H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261469
PNG
(US9708253, 128)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)N1CCS(=O)(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H25F8NO5S2/c27-20-5-7-21(8-6-20)42(39,40)23(11-9-17(10-12-23)22(36)35-13-15-41(37,38)16-14-35)18-1-3-19(4-2-18)24(28,25(29,30)31)26(32,33)34/h1-8,17H,9-16H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261459
PNG
(1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perflu...)
Show SMILES OC(=O)c1cn(nn1)[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H19F8N3O4S/c25-16-5-7-18(8-6-16)40(38,39)21(11-9-17(10-12-21)35-13-19(20(36)37)33-34-35)14-1-3-15(4-2-14)22(26,23(27,28)29)24(30,31)32/h1-8,13,17H,9-12H2,(H,36,37)/t17-,21+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261404
PNG
(US9708253, 62)
Show SMILES Cn1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H23F9N2O3S/c1-41-26-13-14-27(15-18(26)16-40-41,45(42,43)22-11-9-21(31)10-12-22)19-5-7-20(8-6-19)28(29(34,35)36,30(37,38)39)44-17-23-24(32)3-2-4-25(23)33/h2-12,16H,13-15,17H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261403
PNG
(US9708253, 61)
Show SMILES Cn1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H23F9N2O3S/c1-41-16-18-15-27(14-13-26(18)40-41,45(42,43)22-11-9-21(31)10-12-22)19-5-7-20(8-6-19)28(29(34,35)36,30(37,38)39)44-17-23-24(32)3-2-4-25(23)33/h2-12,16H,13-15,17H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261457
PNG
(US9708253, 116)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)-c1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H22F8N4O2S/c29-21-7-9-23(10-8-21)43(41,42)25(19-3-5-20(6-4-19)26(30,27(31,32)33)28(34,35)36)13-11-22(12-14-25)40-17-24(38-39-40)18-2-1-15-37-16-18/h1-10,15-17,22H,11-14H2/t22-,25+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261446
PNG
(US9708253, 105)
Show SMILES CN([C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)c1cccnc1
Show InChI InChI=1S/C28H24F8N2O3S/c1-38(24(39)18-3-2-16-37-17-18)22-12-14-25(15-13-22,42(40,41)23-10-8-21(29)9-11-23)19-4-6-20(7-5-19)26(30,27(31,32)33)28(34,35)36/h2-11,16-17,22H,12-15H2,1H3/t22-,25+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261472
PNG
(US9708253, 131)
Show SMILES CC(=O)N1CCN(CC1)C(=O)C1CCC(CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H28F8N2O4S/c1-18(39)37-14-16-38(17-15-37)24(40)19-10-12-25(13-11-19,43(41,42)23-8-6-22(29)7-9-23)20-2-4-21(5-3-20)26(30,27(31,32)33)28(34,35)36/h2-9,19H,10-17H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261389
PNG
(US9708253, 47 | US9708253, 48)
Show SMILES CS(=O)(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H26F9NO5S2/c1-45(40,41)39-21-13-15-26(16-14-21,46(42,43)22-11-9-20(30)10-12-22)18-5-7-19(8-6-18)27(28(33,34)35,29(36,37)38)44-17-23-24(31)3-2-4-25(23)32/h2-12,21,39H,13-17H2,1H3/t21-,26+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261435
PNG
(N-(4-((4-fluorophenyl)sulfonyl)-4-(4-(1,1,1,3,3,3-...)
Show SMILES CC(C)(C)[S@](=O)N=C1CCC(CC1)(c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C32H32F7NO4S2/c1-28(2,3)45(41)40-26-17-19-29(20-18-26,46(42,43)27-15-13-25(33)14-16-27)23-9-11-24(12-10-23)30(31(34,35)36,32(37,38)39)44-21-22-7-5-4-6-8-22/h4-16H,17-21H2,1-3H3/b40-26-/t29?,45-/m0/s1
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261358
PNG
(US9708253, 16)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)OC(=O)Nc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H27F9N2O5S/c35-23-8-10-26(11-9-23)51(47,48)31(16-12-25(13-17-31)50-30(46)45-24-14-18-44-19-15-24)21-4-6-22(7-5-21)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,14-15,18-19,25H,12-13,16-17,20H2,(H,44,45,46)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261348
PNG
(1,3-difluoro-2-(((1,1,1,3,3,3-hexafluoro-2-(4-(1-(...)
Show SMILES OC1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H23F9O4S/c29-19-8-10-21(11-9-19)42(39,40)25(14-12-20(38)13-15-25)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)41-16-22-23(30)2-1-3-24(22)31/h1-11,20,38H,12-16H2
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261418
PNG
(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)c1ccc(cc1)-n1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H25F9N2O5S/c37-25-10-14-27(15-11-25)53(50,51)33(17-16-31-22(18-33)19-47(46-31)26-12-4-21(5-13-26)32(48)49)23-6-8-24(9-7-23)34(35(40,41)42,36(43,44)45)52-20-28-29(38)2-1-3-30(28)39/h1-15,19H,16-18,20H2,(H,48,49)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261383
PNG
(US9708253, 41)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)c1cn[nH]c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C32H26F9N3O4S/c33-22-8-10-24(11-9-22)49(46,47)29(14-12-23(13-15-29)44-28(45)19-16-42-43-17-19)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)48-18-25-26(34)2-1-3-27(25)35/h1-11,16-17,23H,12-15,18H2,(H,42,43)(H,44,45)/t23-,29+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261437
PNG
(2-((1s,4s)-4-((4-fluorophenyl)sulfonyl)-4-(4-(perf...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)N1C(=O)c2ccncc2C1=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H20F8N2O4S/c29-18-5-7-20(8-6-18)43(41,42)25(16-1-3-17(4-2-16)26(30,27(31,32)33)28(34,35)36)12-9-19(10-13-25)38-23(39)21-11-14-37-15-22(21)24(38)40/h1-8,11,14-15,19H,9-10,12-13H2/t19-,25+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261328
PNG
(US9708253, 2 | methyl 5-(4-(2-((2,6-difluorobenzyl...)
Show SMILES COC(=O)C1CC(CCC1=O)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H23F9O6S/c1-44-26(41)21-15-27(14-13-25(21)40,46(42,43)20-11-9-19(31)10-12-20)17-5-7-18(8-6-17)28(29(34,35)36,30(37,38)39)45-16-22-23(32)3-2-4-24(22)33/h2-12,21H,13-16H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261380
PNG
(US9708253, 38 | US9708253, 40)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)Cc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C35H29F9N2O4S/c36-25-8-10-27(11-9-25)51(48,49)32(16-12-26(13-17-32)46-31(47)20-22-14-18-45-19-15-22)23-4-6-24(7-5-23)33(34(39,40)41,35(42,43)44)50-21-28-29(37)2-1-3-30(28)38/h1-11,14-15,18-19,26H,12-13,16-17,20-21H2,(H,46,47)/t26-,32+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261419
PNG
(2-(5-(4-(2-((2,6-difluorobenzyloxy)oxy)-1,1,1,3,3,...)
Show SMILES CCOC(=O)Cn1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C33H27F9N2O5S/c1-2-48-29(45)18-44-17-20-16-30(15-14-28(20)43-44,50(46,47)24-12-10-23(34)11-13-24)21-6-8-22(9-7-21)31(32(37,38)39,33(40,41)42)49-19-25-26(35)4-3-5-27(25)36/h3-13,17H,2,14-16,18-19H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261452
PNG
(US9708253, 111)
Show SMILES CC1(CCC(CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)NC(=O)c1cccnc1
Show InChI InChI=1S/C28H24F8N2O3S/c1-24(38-23(39)18-3-2-16-37-17-18)12-14-25(15-13-24,42(40,41)22-10-8-21(29)9-11-22)19-4-6-20(7-5-19)26(30,27(31,32)33)28(34,35)36/h2-11,16-17H,12-15H2,1H3,(H,38,39)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261461
PNG
(1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perflu...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C(=O)Nc1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H23F8N5O3S/c30-20-7-9-23(10-8-20)46(44,45)26(18-3-5-19(6-4-18)27(31,28(32,33)34)29(35,36)37)13-11-22(12-14-26)42-17-24(40-41-42)25(43)39-21-2-1-15-38-16-21/h1-10,15-17,22H,11-14H2,(H,39,43)/t22-,26+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261434
PNG
(US9708253, 93 | rac-tert-butyl ((2R,4R)-4-((4-fluo...)
Show SMILES C[C@@H]1C[C@](CCC1NC(=O)OC(C)(C)C)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H30F7NO5S/c1-16-15-24(41(38,39)20-11-9-19(28)10-12-20,14-13-21(16)35-22(36)40-23(2,3)4)17-5-7-18(8-6-17)25(37,26(29,30)31)27(32,33)34/h5-12,16,21,37H,13-15H2,1-4H3,(H,35,36)/t16-,21?,24-/m1/s1
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261361
PNG
(US9708253, 19 | US9708253, 20)
Show SMILES CC(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H26F9NO4S/c1-18(41)40-22-13-15-27(16-14-22,45(42,43)23-11-9-21(31)10-12-23)19-5-7-20(8-6-19)28(29(34,35)36,30(37,38)39)44-17-24-25(32)3-2-4-26(24)33/h2-12,22H,13-17H2,1H3,(H,40,41)/t22-,27+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261463
PNG
(US9708253, 122 | rac-N-((2R,4R)-4-(4-fluorophenyls...)
Show SMILES C[C@@H]1C[C@](CCC1NC(=O)OC(C)(C)C)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H29F8NO4S/c1-16-15-24(41(38,39)20-11-9-19(28)10-12-20,14-13-21(16)36-22(37)40-23(2,3)4)17-5-7-18(8-6-17)25(29,26(30,31)32)27(33,34)35/h5-12,16,21H,13-15H2,1-4H3,(H,36,37)/t16-,21?,24-/m1/s1
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261385
PNG
(US9708253, 43 | US9708253, 44)
Show SMILES COC(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H26F9NO5S/c1-44-26(41)40-21-13-15-27(16-14-21,46(42,43)22-11-9-20(31)10-12-22)18-5-7-19(8-6-18)28(29(34,35)36,30(37,38)39)45-17-23-24(32)3-2-4-25(23)33/h2-12,21H,13-17H2,1H3,(H,40,41)/t21-,27+
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Bristol-Myers Squibb Company

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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261355
PNG
(US9708253, 13)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)OCc1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H28F9NO4S/c35-25-10-12-27(13-11-25)49(45,46)31(16-14-26(15-17-31)47-20-22-3-2-18-44-19-22)23-6-8-24(9-7-23)32(33(38,39)40,34(41,42)43)48-21-28-29(36)4-1-5-30(28)37/h1-13,18-19,26H,14-17,20-21H2
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Bristol-Myers Squibb Company

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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261411
PNG
(US9708253, 69 | US9708253, 70)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCc2c(C1)cnn2C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H29F9N2O4S/c35-24-8-10-26(11-9-24)50(46,47)31(15-12-30-21(18-31)19-44-45(30)25-13-16-48-17-14-25)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,19,25H,12-18,20H2
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Bristol-Myers Squibb Company

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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261408
PNG
(US9708253, 66)
Show SMILES CC(C)n1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C32H27F9N2O3S/c1-19(2)43-28-14-15-29(16-20(28)17-42-43,47(44,45)24-12-10-23(33)11-13-24)21-6-8-22(9-7-21)30(31(36,37)38,32(39,40)41)46-18-25-26(34)4-3-5-27(25)35/h3-13,17,19H,14-16,18H2,1-2H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261426
PNG
(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)c1ccc(cc1)-n1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H25F9N2O5S/c37-25-10-14-27(15-11-25)53(50,51)33(17-16-31-22(18-33)19-46-47(31)26-12-4-21(5-13-26)32(48)49)23-6-8-24(9-7-23)34(35(40,41)42,36(43,44)45)52-20-28-29(38)2-1-3-30(28)39/h1-15,19H,16-18,20H2,(H,48,49)
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Bristol-Myers Squibb Company

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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261443
PNG
(US9708253, 102 | US9708253, 108)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)C(=O)NCc1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H24F8N2O3S/c29-22-5-7-23(8-6-22)42(40,41)25(13-9-19(10-14-25)24(39)38-17-18-11-15-37-16-12-18)20-1-3-21(4-2-20)26(30,27(31,32)33)28(34,35)36/h1-8,11-12,15-16,19H,9-10,13-14,17H2,(H,38,39)
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261458
PNG
(US9708253, 117)
Show SMILES CC(C)(C)OC(=O)N1CC(C1)c1cn(nn1)[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H32F8N4O4S/c1-27(2,3)47-26(44)42-16-19(17-42)25-18-43(41-40-25)23-12-14-28(15-13-23,48(45,46)24-10-8-22(32)9-11-24)20-4-6-21(7-5-20)29(33,30(34,35)36)31(37,38)39/h4-11,18-19,23H,12-17H2,1-3H3/t23-,28+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261406
PNG
(US9708253, 64)
Show SMILES CCn1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H25F9N2O3S/c1-2-42-17-19-16-28(15-14-27(19)41-42,46(43,44)23-12-10-22(32)11-13-23)20-6-8-21(9-7-20)29(30(35,36)37,31(38,39)40)45-18-24-25(33)4-3-5-26(24)34/h3-13,17H,2,14-16,18H2,1H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261413
PNG
(N-(6-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES CC(=O)Nc1nc2CCC(Cc2s1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H23F9N2O4S2/c1-17(43)41-27-42-25-13-14-28(15-26(25)47-27,48(44,45)21-11-9-20(32)10-12-21)18-5-7-19(8-6-18)29(30(35,36)37,31(38,39)40)46-16-22-23(33)3-2-4-24(22)34/h2-12H,13-16H2,1H3,(H,41,42,43)
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261415
PNG
(US9708253, 74)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCc2nn(cc2C1)-c1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H24F9N3O3S/c35-24-8-10-26(11-9-24)50(47,48)31(15-12-30-21(18-31)19-46(45-30)25-13-16-44-17-14-25)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,13-14,16-17,19H,12,15,18,20H2/t31-/m1/s1
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261416
PNG
(1-(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,...)
Show SMILES CC(=O)N1CCC(CC1)n1cc2C[C@](CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H32F9N3O4S/c1-22(49)47-17-14-27(15-18-47)48-20-23-19-33(16-13-32(23)46-48,53(50,51)28-11-9-26(37)10-12-28)24-5-7-25(8-6-24)34(35(40,41)42,36(43,44)45)52-21-29-30(38)3-2-4-31(29)39/h2-12,20,27H,13-19,21H2,1H3/t33-/m1/s1
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261373
PNG
(US9708253, 31 | US9708253, 32)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N[C@H]1CC[C@@](CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H35F9N2O5S/c1-22(48)47-19-15-23(16-20-47)32(49)46-27-13-17-33(18-14-27,53(50,51)28-11-9-26(37)10-12-28)24-5-7-25(8-6-24)34(35(40,41)42,36(43,44)45)52-21-29-30(38)3-2-4-31(29)39/h2-12,23,27H,13-21H2,1H3,(H,46,49)/t27-,33+
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261442
PNG
(US9708253, 101)
Show SMILES OC(c1ccc(cc1)[C@@]1(CC[C@@H](CC1)NC(=O)Cc1ccncc1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H25F7N2O4S/c29-21-5-7-23(8-6-21)42(40,41)25(13-9-22(10-14-25)37-24(38)17-18-11-15-36-16-12-18)19-1-3-20(4-2-19)26(39,27(30,31)32)28(33,34)35/h1-8,11-12,15-16,22,39H,9-10,13-14,17H2,(H,37,38)/t22-,25-
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261430
PNG
(4-(4-(2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCC(CC1)C#N)c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H24F7NO3S/c30-24-10-12-25(13-11-24)41(38,39)26(16-14-20(18-37)15-17-26)22-6-8-23(9-7-22)27(28(31,32)33,29(34,35)36)40-19-21-4-2-1-3-5-21/h1-13,20H,14-17,19H2/t20?,26-
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261407
PNG
(US9708253, 65)
Show SMILES CC(C)n1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C32H27F9N2O3S/c1-19(2)43-17-20-16-29(15-14-28(20)42-43,47(44,45)24-12-10-23(33)11-13-24)21-6-8-22(9-7-21)30(31(36,37)38,32(39,40)41)46-18-25-26(34)4-3-5-27(25)35/h3-13,17,19H,14-16,18H2,1-2H3
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261441
PNG
(US9708253, 100)
Show SMILES OC(c1ccc(cc1)[C@@]1(CC[C@@H](CC1)NC(=O)c1cccnc1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H23F7N2O4S/c28-20-7-9-22(10-8-20)41(39,40)24(13-11-21(12-14-24)36-23(37)17-2-1-15-35-16-17)18-3-5-19(6-4-18)25(38,26(29,30)31)27(32,33)34/h1-10,15-16,21,38H,11-14H2,(H,36,37)/t21-,24-
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The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261387
PNG
(US9708253, 45)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@]1(CC[C@@H](CC1)NC(=O)N1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C33H31F9N2O5S/c34-23-8-10-25(11-9-23)50(46,47)30(14-12-24(13-15-30)43-29(45)44-16-18-48-19-17-44)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)49-20-26-27(35)2-1-3-28(26)36/h1-11,24H,12-20H2,(H,43,45)/t24-,30-
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261417
PNG
(1-(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,...)
Show SMILES CC(=O)N1CCC(CC1)n1cc2C[C@@](CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H32F9N3O4S/c1-22(49)47-17-14-27(15-18-47)48-20-23-19-33(16-13-32(23)46-48,53(50,51)28-11-9-26(37)10-12-28)24-5-7-25(8-6-24)34(35(40,41)42,36(43,44)45)52-21-29-30(38)3-2-4-31(29)39/h2-12,20,27H,13-19,21H2,1H3/t33-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


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More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261420
PNG
(2-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)Cn1ncc2CC(CCc12)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H23F9N2O5S/c32-21-8-10-22(11-9-21)48(45,46)28(13-12-26-18(14-28)15-41-42(26)16-27(43)44)19-4-6-20(7-5-19)29(30(35,36)37,31(38,39)40)47-17-23-24(33)2-1-3-25(23)34/h1-11,15H,12-14,16-17H2,(H,43,44)
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n/an/a 2.42E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261376
PNG
(US9708253, 34 | US9708253, 35)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C34H32F9NO5S/c35-24-8-10-26(11-9-24)50(46,47)31(16-12-25(13-17-31)44-30(45)21-14-18-48-19-15-21)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)49-20-27-28(36)2-1-3-29(27)37/h1-11,21,25H,12-20H2,(H,44,45)/t25-,31+
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n/an/a 2.46E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261363
PNG
(US9708253, 21 | US9708253, 22)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)NC(=O)CC#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C31H25F9N2O4S/c32-21-8-10-23(11-9-21)47(44,45)28(15-12-22(13-16-28)42-27(43)14-17-41)19-4-6-20(7-5-19)29(30(35,36)37,31(38,39)40)46-18-24-25(33)2-1-3-26(24)34/h1-11,22H,12-16,18H2,(H,42,43)/t22-,28+
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n/an/a 2.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261431
PNG
(4-(4-(2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCC(CC1)C#N)c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H24F7NO3S/c30-24-10-12-25(13-11-24)41(38,39)26(16-14-20(18-37)15-17-26)22-6-8-23(9-7-22)27(28(31,32)33,29(34,35)36)40-19-21-4-2-1-3-5-21/h1-13,20H,14-17,19H2/t20?,26-
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261353
PNG
(6-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexa...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(=O)C(Br)C1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H20BrF9O4S/c29-21-14-25(13-12-24(21)39,43(40,41)19-10-8-18(30)9-11-19)16-4-6-17(7-5-16)26(27(33,34)35,28(36,37)38)42-15-20-22(31)2-1-3-23(20)32/h1-11,21H,12-15H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261357
PNG
(US9708253, 15)
Show SMILES CCNC(=O)OC1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H28F9NO5S/c1-2-41-27(42)46-22-14-16-28(17-15-22,47(43,44)23-12-10-21(32)11-13-23)19-6-8-20(9-7-19)29(30(35,36)37,31(38,39)40)45-18-24-25(33)4-3-5-26(24)34/h3-13,22H,2,14-18H2,1H3,(H,41,42)
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n/an/a 3.68E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261427
PNG
(4-(5-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-h...)
Show SMILES OC(=O)C1CCC(CC1)n1cc2CC(CCc2n1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C36H31F9N2O5S/c37-25-10-14-27(15-11-25)53(50,51)33(17-16-31-22(18-33)19-47(46-31)26-12-4-21(5-13-26)32(48)49)23-6-8-24(9-7-23)34(35(40,41)42,36(43,44)45)52-20-28-29(38)2-1-3-30(28)39/h1-3,6-11,14-15,19,21,26H,4-5,12-13,16-18,20H2,(H,48,49)
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n/an/a 3.85E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
RAR-related orphan receptor C (RORc)


(Homo sapiens (Human))
BDBM261423
PNG
(1-(4-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C1(CCC(CC1)N1CCN(Cc2ccccc2)CC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C39H37F9N2O3S/c40-30-13-15-32(16-14-30)54(51,52)36(19-17-31(18-20-36)50-23-21-49(22-24-50)25-27-5-2-1-3-6-27)28-9-11-29(12-10-28)37(38(43,44)45,39(46,47)48)53-26-33-34(41)7-4-8-35(33)42/h1-16,31H,17-26H2
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n/an/a 3.92E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%