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Patent code US9708270

Compile Data Set for Download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 120


(Homo sapiens)
BDBM261529
PNG
(US9708270, 24)
Show SMILES CC(C)c1cc(cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1)C#N
Show InChI InChI=1S/C22H30N2O2/c1-16(2)19-11-18(15-23)12-20(14-19)24-9-7-22(8-10-24)5-3-17(4-6-22)13-21(25)26/h11-12,14,16-17H,3-10,13H2,1-2H3,(H,25,26)
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n/an/an/an/a 3.46E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261519
PNG
(US9708270, 14)
Show SMILES COc1ccc(Cl)cc1N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-17-3-2-15(20)13-16(17)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261523
PNG
(US9708270, 18)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H30ClNO3/c1-15(2)26-17-3-4-18(22)19(14-17)23-11-9-21(10-12-23)7-5-16(6-8-21)13-20(24)25/h3-4,14-16H,5-13H2,1-2H3,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261542
PNG
(US9708270, 37)
Show SMILES Cc1cc(F)c(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H25ClFNO2/c1-13-10-15(21)18(20)16(11-13)22-8-6-19(7-9-22)4-2-14(3-5-19)12-17(23)24/h10-11,14H,2-9,12H2,1H3,(H,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261553
PNG
(US9708270, 48)
Show SMILES Cc1cc(OC(F)(F)F)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H26F3NO3/c1-14-10-16(13-17(11-14)27-20(21,22)23)24-8-6-19(7-9-24)4-2-15(3-5-19)12-18(25)26/h10-11,13,15H,2-9,12H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261558
PNG
(US9708270, 53)
Show SMILES CSc1cc(cc(c1)C(F)(F)F)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H26F3NO2S/c1-27-17-12-15(20(21,22)23)11-16(13-17)24-8-6-19(7-9-24)4-2-14(3-5-19)10-18(25)26/h11-14H,2-10H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261565
PNG
(US9708270, 60)
Show SMILES CC(C)Oc1cc(F)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H30FNO3/c1-15(2)26-19-13-17(22)12-18(14-19)23-9-7-21(8-10-23)5-3-16(4-6-21)11-20(24)25/h12-16H,3-11H2,1-2H3,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261573
PNG
(US9708270, 68)
Show SMILES Cc1cc(F)cc(N2CCC3(CCC(CC(O)=O)CC3)CC2)c1Cl
Show InChI InChI=1S/C19H25ClFNO2/c1-13-10-15(21)12-16(18(13)20)22-8-6-19(7-9-22)4-2-14(3-5-19)11-17(23)24/h10,12,14H,2-9,11H2,1H3,(H,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261594
PNG
(US9708270, 98)
Show SMILES OC(=O)C[C@@H]1CCC2(CCN(CC2)c2cc(OC3CCC3)ccc2Cl)OC1
Show InChI InChI=1S/C21H28ClNO4/c22-18-5-4-17(27-16-2-1-3-16)13-19(18)23-10-8-21(9-11-23)7-6-15(14-26-21)12-20(24)25/h4-5,13,15-16H,1-3,6-12,14H2,(H,24,25)/t15-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261597
PNG
(US9708270, 101)
Show SMILES COc1cc(F)cc(c1)N1CCC2(CC(CC(O)=O)CO2)CC1
Show InChI InChI=1S/C17H22FNO4/c1-22-15-8-13(18)7-14(9-15)19-4-2-17(3-5-19)10-12(11-23-17)6-16(20)21/h7-9,12H,2-6,10-11H2,1H3,(H,20,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261524
PNG
(US9708270, 19)
Show SMILES Cc1cc(C)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H29NO2/c1-15-11-16(2)13-18(12-15)21-9-7-20(8-10-21)5-3-17(4-6-20)14-19(22)23/h11-13,17H,3-10,14H2,1-2H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261527
PNG
(US9708270, 22)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(cc(c1)C(F)F)C(F)F
Show InChI InChI=1S/C20H25F4NO2/c21-18(22)14-10-15(19(23)24)12-16(11-14)25-7-5-20(6-8-25)3-1-13(2-4-20)9-17(26)27/h10-13,18-19H,1-9H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261528
PNG
(US9708270, 23)
Show SMILES CC(C)(C)c1cc(cc(c1)C(F)(F)F)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C23H32F3NO2/c1-21(2,3)17-13-18(23(24,25)26)15-19(14-17)27-10-8-22(9-11-27)6-4-16(5-7-22)12-20(28)29/h13-16H,4-12H2,1-3H3,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261531
PNG
(US9708270, 26)
Show SMILES CSc1nc(cc(n1)C(F)(F)F)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C18H24F3N3O2S/c1-27-16-22-13(18(19,20)21)11-14(23-16)24-8-6-17(7-9-24)4-2-12(3-5-17)10-15(25)26/h11-12H,2-10H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261533
PNG
(US9708270, 28)
Show SMILES Cc1cc(F)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26FNO2/c1-14-10-16(20)13-17(11-14)21-8-6-19(7-9-21)4-2-15(3-5-19)12-18(22)23/h10-11,13,15H,2-9,12H2,1H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261534
PNG
(US9708270, 29)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C18H23ClFNO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261514
PNG
(US9708270, 9)
Show SMILES Cc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO2/c1-14-2-3-16(20)17(12-14)21-10-8-19(9-11-21)6-4-15(5-7-19)13-18(22)23/h2-3,12,15H,4-11,13H2,1H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261515
PNG
(US9708270, 10)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C18H23ClN2O4/c19-15-2-1-14(21(24)25)12-16(15)20-9-7-18(8-10-20)5-3-13(4-6-18)11-17(22)23/h1-2,12-13H,3-11H2,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261549
PNG
(US9708270, 44)
Show SMILES CCc1cc(CC)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C22H33NO2/c1-3-17-13-18(4-2)15-20(14-17)23-11-9-22(10-12-23)7-5-19(6-8-22)16-21(24)25/h13-15,19H,3-12,16H2,1-2H3,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261552
PNG
(US9708270, 47)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC2CCC2)ccc1Cl
Show InChI InChI=1S/C22H30ClNO3/c23-19-5-4-18(27-17-2-1-3-17)15-20(19)24-12-10-22(11-13-24)8-6-16(7-9-22)14-21(25)26/h4-5,15-17H,1-3,6-14H2,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261568
PNG
(US9708270, 63)
Show SMILES Cc1ccc(F)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26FNO2/c1-14-2-3-16(20)17(12-14)21-10-8-19(9-11-21)6-4-15(5-7-19)13-18(22)23/h2-3,12,15H,4-11,13H2,1H3,(H,22,23)
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n/an/an/an/a 2.32E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261576
PNG
(US9708270, 71)
Show SMILES Cc1cc(cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1)C#N
Show InChI InChI=1S/C20H26N2O2/c1-15-10-17(14-21)12-18(11-15)22-8-6-20(7-9-22)4-2-16(3-5-20)13-19(23)24/h10-12,16H,2-9,13H2,1H3,(H,23,24)
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n/an/an/an/a 2.96E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261589
PNG
(US9708270, 86)
Show SMILES OC(=O)CCCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C21H27ClF3NO3/c22-17-5-4-16(29-21(23,24)25)14-18(17)26-12-10-20(11-13-26)8-6-15(7-9-20)2-1-3-19(27)28/h4-5,14-15H,1-3,6-13H2,(H,27,28)
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n/an/an/an/a 2.02E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261596
PNG
(US9708270, 100 | US9708270, 103)
Show SMILES OC(=O)C[C@@H]1CCC2(CCN(CC2)c2cc(OC3CCC3)ccc2F)OC1
Show InChI InChI=1S/C21H28FNO4/c22-18-5-4-17(27-16-2-1-3-16)13-19(18)23-10-8-21(9-11-23)7-6-15(14-26-21)12-20(24)25/h4-5,13,15-16H,1-3,6-12,14H2,(H,24,25)/t15-/m0/s1
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n/an/an/an/a 3.25E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261520
PNG
(US9708270, 15)
Show SMILES COc1ccc(cc1N1CCC2(CCC(CC(O)=O)CC2)CC1)C(F)(F)F
Show InChI InChI=1S/C20H26F3NO3/c1-27-17-3-2-15(20(21,22)23)13-16(17)24-10-8-19(9-11-24)6-4-14(5-7-19)12-18(25)26/h2-3,13-14H,4-12H2,1H3,(H,25,26)
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n/an/an/an/a 2.36E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a 3.06E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261539
PNG
(US9708270, 34)
Show SMILES Cc1cc(cc(c1)C(F)(F)F)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H26F3NO2/c1-14-10-16(20(21,22)23)13-17(11-14)24-8-6-19(7-9-24)4-2-15(3-5-19)12-18(25)26/h10-11,13,15H,2-9,12H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261560
PNG
(US9708270, 55)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC2CC2)ccc1Cl
Show InChI InChI=1S/C21H28ClNO3/c22-18-4-3-17(26-16-1-2-16)14-19(18)23-11-9-21(10-12-23)7-5-15(6-8-21)13-20(24)25/h3-4,14-16H,1-2,5-13H2,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261566
PNG
(US9708270, 61)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)F)ccc1Cl
Show InChI InChI=1S/C19H24ClF2NO3/c20-15-2-1-14(26-18(21)22)12-16(15)23-9-7-19(8-10-23)5-3-13(4-6-19)11-17(24)25/h1-2,12-13,18H,3-11H2,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261570
PNG
(US9708270, 65)
Show SMILES Cc1ccc(cc1N1CCC2(CCC(CC(O)=O)CC2)CC1)C#N
Show InChI InChI=1S/C20H26N2O2/c1-15-2-3-17(14-21)12-18(15)22-10-8-20(9-11-22)6-4-16(5-7-20)13-19(23)24/h2-3,12,16H,4-11,13H2,1H3,(H,23,24)
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n/an/an/an/a 2.51E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261579
PNG
(US9708270, 74)
Show SMILES COc1cc(N2CCC3(CCC(CC(O)=O)CC3)CC2)c(F)cn1
Show InChI InChI=1S/C18H25FN2O3/c1-24-16-11-15(14(19)12-20-16)21-8-6-18(7-9-21)4-2-13(3-5-18)10-17(22)23/h11-13H,2-10H2,1H3,(H,22,23)
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n/an/an/an/a 3.42E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261582
PNG
(US9708270, 77)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H29NO2/c26-23(27)18-19-10-12-24(13-11-19)14-16-25(17-15-24)22-8-6-21(7-9-22)20-4-2-1-3-5-20/h1-9,19H,10-18H2,(H,26,27)
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n/an/an/an/a 4.94E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261587
PNG
(US9708270, 84)
Show SMILES OC(=O)CCC1CCC2(CC1)CCN(CC2)c1cc(OC2CCC2)ccc1Cl
Show InChI InChI=1S/C23H32ClNO3/c24-20-6-5-19(28-18-2-1-3-18)16-21(20)25-14-12-23(13-15-25)10-8-17(9-11-23)4-7-22(26)27/h5-6,16-18H,1-4,7-15H2,(H,26,27)
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n/an/an/an/a 1.35E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261600
PNG
(US9708270, 106)
Show SMILES FC(F)(F)Oc1ccc(C#N)c(c1)N1CCC2(CCC(CCOC=O)C2)CC1
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-17-2-1-16(13-24)18(11-17)25-8-6-19(7-9-25)5-3-15(12-19)4-10-27-14-26/h1-2,11,14-15H,3-10,12H2
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n/an/an/an/a 220n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
IP1 assay results were obtained adapting the GPR120 assay described in C. Bergsdorf, et al., Assay Drug Dev. Technol., 2008, 6(1), 39-53.


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261510
PNG
(US9708270, 6)
Show SMILES COc1cc(F)c(cc1F)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H25F2NO3/c1-25-17-12-14(20)16(11-15(17)21)22-8-6-19(7-9-22)4-2-13(3-5-19)10-18(23)24/h11-13H,2-10H2,1H3,(H,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261537
PNG
(US9708270, 32)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H23F6NO2/c21-19(22,23)14-10-15(20(24,25)26)12-16(11-14)27-7-5-18(6-8-27)3-1-13(2-4-18)9-17(28)29/h10-13H,1-9H2,(H,28,29)
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n/an/an/an/a 2.15E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208154
PNG
(CHEMBL3973034 | US9708270, 35)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-16-2-1-15(13-24)17(12-16)25-9-7-19(8-10-25)5-3-14(4-6-19)11-18(26)27/h1-2,12,14H,3-11H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261559
PNG
(US9708270, 54)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1O
Show InChI InChI=1S/C19H24F3NO4/c20-19(21,22)27-14-1-2-16(24)15(12-14)23-9-7-18(8-10-23)5-3-13(4-6-18)11-17(25)26/h1-2,12-13,24H,3-11H2,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261562
PNG
(US9708270, 57)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC2CCC2)ccc1C#N
Show InChI InChI=1S/C23H30N2O3/c24-16-18-4-5-20(28-19-2-1-3-19)15-21(18)25-12-10-23(11-13-25)8-6-17(7-9-23)14-22(26)27/h4-5,15,17,19H,1-3,6-14H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261563
PNG
(US9708270, 58)
Show SMILES Cc1ccc(C)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H29NO2/c1-15-3-4-16(2)18(13-15)21-11-9-20(10-12-21)7-5-17(6-8-20)14-19(22)23/h3-4,13,17H,5-12,14H2,1-2H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261569
PNG
(US9708270, 64)
Show SMILES COc1cccc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H27NO3/c1-23-17-4-2-3-16(14-17)20-11-9-19(10-12-20)7-5-15(6-8-19)13-18(21)22/h2-4,14-15H,5-13H2,1H3,(H,21,22)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261571
PNG
(US9708270, 66 | US9708270, 81)
Show SMILES CSc1cccc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H27NO2S/c1-23-17-4-2-3-16(14-17)20-11-9-19(10-12-20)7-5-15(6-8-19)13-18(21)22/h2-4,14-15H,5-13H2,1H3,(H,21,22)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261572
PNG
(US9708270, 67)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(c1)C(F)F
Show InChI InChI=1S/C19H24F3NO2/c20-15-10-14(18(21)22)11-16(12-15)23-7-5-19(6-8-23)3-1-13(2-4-19)9-17(24)25/h10-13,18H,1-9H2,(H,24,25)
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n/an/an/an/a 2.64E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261574
PNG
(US9708270, 69)
Show SMILES CN(C)c1cccc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H30N2O2/c1-21(2)17-4-3-5-18(15-17)22-12-10-20(11-13-22)8-6-16(7-9-20)14-19(23)24/h3-5,15-16H,6-14H2,1-2H3,(H,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261575
PNG
(US9708270, 70)
Show SMILES Cc1cccc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H27NO2/c1-15-3-2-4-17(13-15)20-11-9-19(10-12-20)7-5-16(6-8-19)14-18(21)22/h2-4,13,16H,5-12,14H2,1H3,(H,21,22)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261581
PNG
(US9708270, 76)
Show SMILES Cc1cccc(Oc2ccc(C#N)c(c2)N2CCC3(CCC(CC(O)=O)CC3)CC2)n1
Show InChI InChI=1S/C25H29N3O3/c1-18-3-2-4-23(27-18)31-21-6-5-20(17-26)22(16-21)28-13-11-25(12-14-28)9-7-19(8-10-25)15-24(29)30/h2-6,16,19H,7-15H2,1H3,(H,29,30)
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n/an/an/an/a 4.22E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261595
PNG
(US9708270, 99)
Show SMILES OC(=O)C[C@H]1CCC2(CCN(CC2)c2cc(OC3CCC3)ccc2Cl)OC1
Show InChI InChI=1S/C21H28ClNO4/c22-18-5-4-17(27-16-2-1-3-16)13-19(18)23-10-8-21(9-11-23)7-6-15(14-26-21)12-20(24)25/h4-5,13,15-16H,1-3,6-12,14H2,(H,24,25)/t15-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261598
PNG
(US9708270, 102)
Show SMILES COc1cc(Cl)cc(c1)N1CCC2(CC(CC(O)=O)CO2)CC1
Show InChI InChI=1S/C17H22ClNO4/c1-22-15-8-13(18)7-14(9-15)19-4-2-17(3-5-19)10-12(11-23-17)6-16(20)21/h7-9,12H,2-6,10-11H2,1H3,(H,20,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261532
PNG
(US9708270, 27)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(cc(n1)C(F)F)C(F)F
Show InChI InChI=1S/C19H24F4N2O2/c20-17(21)13-10-14(18(22)23)24-15(11-13)25-7-5-19(6-8-25)3-1-12(2-4-19)9-16(26)27/h10-12,17-18H,1-9H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261522
PNG
(US9708270, 17)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)ccc1C#N
Show InChI InChI=1S/C19H23FN2O2/c20-16-2-1-15(13-21)17(12-16)22-9-7-19(8-10-22)5-3-14(4-6-19)11-18(23)24/h1-2,12,14H,3-11H2,(H,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261547
PNG
(US9708270, 42)
Show SMILES Cc1ccc(cc1N1CCC2(CCC(CC(O)=O)CC2)CC1)C(F)(F)F
Show InChI InChI=1S/C20H26F3NO2/c1-14-2-3-16(20(21,22)23)13-17(14)24-10-8-19(9-11-24)6-4-15(5-7-19)12-18(25)26/h2-3,13,15H,4-12H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261561
PNG
(US9708270, 56)
Show SMILES CC(C)Oc1cc(OC(F)(F)F)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C22H30F3NO4/c1-15(2)29-18-12-17(13-19(14-18)30-22(23,24)25)26-9-7-21(8-10-26)5-3-16(4-6-21)11-20(27)28/h12-16H,3-11H2,1-2H3,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261564
PNG
(US9708270, 59)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C20H23F6NO3/c21-19(22,23)14-10-15(12-16(11-14)30-20(24,25)26)27-7-5-18(6-8-27)3-1-13(2-4-18)9-17(28)29/h10-13H,1-9H2,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261577
PNG
(US9708270, 72)
Show SMILES COc1cc(C)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H29NO3/c1-15-11-17(14-18(12-15)24-2)21-9-7-20(8-10-21)5-3-16(4-6-20)13-19(22)23/h11-12,14,16H,3-10,13H2,1-2H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208151
PNG
(CHEMBL3986483 | US9708270, 97)
Show SMILES OC(=O)CC1CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2Cl)OC1
Show InChI InChI=1S/C18H21ClF3NO4/c19-14-2-1-13(27-18(20,21)22)10-15(14)23-7-5-17(6-8-23)4-3-12(11-26-17)9-16(24)25/h1-2,10,12H,3-9,11H2,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261525
PNG
(US9708270, 20)
Show SMILES CCC(=O)c1ccc(F)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H28FNO3/c1-2-19(24)16-3-4-17(22)18(14-16)23-11-9-21(10-12-23)7-5-15(6-8-21)13-20(25)26/h3-4,14-15H,2,5-13H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261526
PNG
(US9708270, 21)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H23F6NO2/c21-19(22,23)14-1-2-15(20(24,25)26)16(12-14)27-9-7-18(8-10-27)5-3-13(4-6-18)11-17(28)29/h1-2,12-13H,3-11H2,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208148
PNG
(CHEMBL3891920 | US9708270, 7)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261517
PNG
(US9708270, 12)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)ccc1C(F)F
Show InChI InChI=1S/C19H24F3NO2/c20-14-1-2-15(18(21)22)16(12-14)23-9-7-19(8-10-23)5-3-13(4-6-19)11-17(24)25/h1-2,12-13,18H,3-11H2,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261546
PNG
(US9708270, 41)
Show SMILES CSc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H26F3NO3S/c1-28-17-3-2-15(27-20(21,22)23)13-16(17)24-10-8-19(9-11-24)6-4-14(5-7-19)12-18(25)26/h2-3,13-14H,4-12H2,1H3,(H,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261548
PNG
(US9708270, 43)
Show SMILES Cc1cc(C)c(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H28ClNO2/c1-14-11-15(2)19(21)17(12-14)22-9-7-20(8-10-22)5-3-16(4-6-20)13-18(23)24/h11-12,16H,3-10,13H2,1-2H3,(H,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261556
PNG
(US9708270, 51)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261567
PNG
(US9708270, 62)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC2CC2)ccc1F
Show InChI InChI=1S/C21H28FNO3/c22-18-4-3-17(26-16-1-2-16)14-19(18)23-11-9-21(10-12-23)7-5-15(6-8-21)13-20(24)25/h3-4,14-16H,1-2,5-13H2,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261578
PNG
(US9708270, 73)
Show SMILES OCc1ccc(cc1N1CCC2(CCC(CC(O)=O)CC2)CC1)C(F)(F)F
Show InChI InChI=1S/C20H26F3NO3/c21-20(22,23)16-2-1-15(13-25)17(12-16)24-9-7-19(8-10-24)5-3-14(4-6-19)11-18(26)27/h1-2,12,14,25H,3-11,13H2,(H,26,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261592
PNG
(US9708270, 96)
Show SMILES OC(=O)CC1CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2F)OC1
Show InChI InChI=1S/C18H21F4NO4/c19-14-2-1-13(27-18(20,21)22)10-15(14)23-7-5-17(6-8-23)4-3-12(11-26-17)9-16(24)25/h1-2,10,12H,3-9,11H2,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261601
PNG
(US9708270, 107)
Show SMILES COc1cc(F)c(cc1OC1CCC1)N1CCC2(CCC(CCOC=O)C2)CC1
Show InChI InChI=1S/C23H32FNO4/c1-27-21-13-19(24)20(14-22(21)29-18-3-2-4-18)25-10-8-23(9-11-25)7-5-17(15-23)6-12-28-16-26/h13-14,16-18H,2-12,15H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
IP1 assay results were obtained adapting the GPR120 assay described in C. Bergsdorf, et al., Assay Drug Dev. Technol., 2008, 6(1), 39-53.


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208146
PNG
(CHEMBL3901994 | US9708270, 38)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 2.15E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261545
PNG
(US9708270, 40)
Show SMILES Cc1cc(Cl)cc(N2CCC3(CCC(CC(O)=O)CC3)CC2)c1C#N
Show InChI InChI=1S/C20H25ClN2O2/c1-14-10-16(21)12-18(17(14)13-22)23-8-6-20(7-9-23)4-2-15(3-5-20)11-19(24)25/h10,12,15H,2-9,11H2,1H3,(H,24,25)
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n/an/an/an/a 2.54E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261550
PNG
(US9708270, 45)
Show SMILES Cc1cc(Cl)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO2/c1-14-10-16(20)13-17(11-14)21-8-6-19(7-9-21)4-2-15(3-5-19)12-18(22)23/h10-11,13,15H,2-9,12H2,1H3,(H,22,23)
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n/an/an/an/a 1.17E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261590
PNG
(US9708270, 87)
Show SMILES OC(=O)CCCC1CCC2(CC1)CCN(CC2)c1cc(OC2CCC2)ccc1Cl
Show InChI InChI=1S/C24H34ClNO3/c25-21-8-7-20(29-19-4-2-5-19)17-22(21)26-15-13-24(14-16-26)11-9-18(10-12-24)3-1-6-23(27)28/h7-8,17-19H,1-6,9-16H2,(H,27,28)
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n/an/an/an/a 2.26E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261518
PNG
(US9708270, 13)
Show SMILES Cc1ccc(C#N)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H26N2O2/c1-15-2-3-17(14-21)18(12-15)22-10-8-20(9-11-22)6-4-16(5-7-20)13-19(23)24/h2-3,12,16H,4-11,13H2,1H3,(H,23,24)
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n/an/an/an/a 2.14E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261536
PNG
(US9708270, 31)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-10-14(19(21,22)23)11-16(12-15)24-7-5-18(6-8-24)3-1-13(2-4-18)9-17(25)26/h10-13H,1-9H2,(H,25,26)
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n/an/an/an/a 1.22E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261541
PNG
(US9708270, 36)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(c1)C(F)(F)F
Show InChI InChI=1S/C19H23ClF3NO2/c20-15-10-14(19(21,22)23)11-16(12-15)24-7-5-18(6-8-24)3-1-13(2-4-18)9-17(25)26/h10-13H,1-9H2,(H,25,26)
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n/an/an/an/a 832n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261544
PNG
(US9708270, 39)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(F)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-13-10-14(20)17(21)15(11-13)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261551
PNG
(US9708270, 46)
Show SMILES CCc1cc(C)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H31NO2/c1-3-17-12-16(2)13-19(14-17)22-10-8-21(9-11-22)6-4-18(5-7-21)15-20(23)24/h12-14,18H,3-11,15H2,1-2H3,(H,23,24)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261554
PNG
(US9708270, 49)
Show SMILES COc1cc(OC(F)(F)F)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C20H26F3NO4/c1-27-16-11-15(12-17(13-16)28-20(21,22)23)24-8-6-19(7-9-24)4-2-14(3-5-19)10-18(25)26/h11-14H,2-10H2,1H3,(H,25,26)
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n/an/an/an/a 449n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208152
PNG
(CHEMBL3967504 | US9708270, 50)
Show SMILES OCCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H25ClF3NO2/c20-16-2-1-15(26-19(21,22)23)13-17(16)24-10-8-18(9-11-24)6-3-14(4-7-18)5-12-25/h1-2,13-14,25H,3-12H2
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n/an/an/an/a 472n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261557
PNG
(US9708270, 52)
Show SMILES CC(C)Oc1cc(Cl)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H30ClNO3/c1-15(2)26-19-13-17(22)12-18(14-19)23-9-7-21(8-10-23)5-3-16(4-6-21)11-20(24)25/h12-16H,3-11H2,1-2H3,(H,24,25)
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n/an/an/an/a 641n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261580
PNG
(US9708270, 75)
Show SMILES COCCOc1cc(Cl)cc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H30ClNO4/c1-26-10-11-27-19-14-17(22)13-18(15-19)23-8-6-21(7-9-23)4-2-16(3-5-21)12-20(24)25/h13-16H,2-12H2,1H3,(H,24,25)
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n/an/an/an/a 3.63E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261583
PNG
(US9708270, 78)
Show SMILES Cc1ccnc(Oc2ccc(C#N)c(c2)N2CCC3(CCC(CC(O)=O)CC3)CC2)c1
Show InChI InChI=1S/C25H29N3O3/c1-18-6-11-27-23(14-18)31-21-3-2-20(17-26)22(16-21)28-12-9-25(10-13-28)7-4-19(5-8-25)15-24(29)30/h2-3,6,11,14,16,19H,4-5,7-10,12-13,15H2,1H3,(H,29,30)
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n/an/an/an/a 4.97E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261584
PNG
(US9708270, 79)
Show SMILES Cc1cccnc1Oc1ccc(C#N)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C25H29N3O3/c1-18-3-2-12-27-24(18)31-21-5-4-20(17-26)22(16-21)28-13-10-25(11-14-28)8-6-19(7-9-25)15-23(29)30/h2-5,12,16,19H,6-11,13-15H2,1H3,(H,29,30)
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n/an/an/an/a 6.57E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261585
PNG
(US9708270, 80)
Show SMILES COCCOc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C21H30ClNO4/c1-26-12-13-27-17-2-3-18(22)19(15-17)23-10-8-21(9-11-23)6-4-16(5-7-21)14-20(24)25/h2-3,15-16H,4-14H2,1H3,(H,24,25)
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n/an/an/an/a 6.97E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261571
PNG
(US9708270, 66 | US9708270, 81)
Show SMILES CSc1cccc(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H27NO2S/c1-23-17-4-2-3-16(14-17)20-11-9-19(10-12-20)7-5-15(6-8-19)13-18(21)22/h2-4,14-15H,5-13H2,1H3,(H,21,22)
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n/an/an/an/a 2.58E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM50208094
PNG
(CHEMBL3897637 | US9708270, 85)
Show SMILES OC(=O)CCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c21-16-3-2-15(28-20(22,23)24)13-17(16)25-11-9-19(10-12-25)7-5-14(6-8-19)1-4-18(26)27/h2-3,13-14H,1,4-12H2,(H,26,27)
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n/an/an/an/a 1.79E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261591
PNG
(US9708270, 95)
Show SMILES OC(=O)CC1CCC2(CCN(CC2)c2cccc(OC(F)(F)F)c2)OC1
Show InChI InChI=1S/C18H22F3NO4/c19-18(20,21)26-15-3-1-2-14(11-15)22-8-6-17(7-9-22)5-4-13(12-25-17)10-16(23)24/h1-3,11,13H,4-10,12H2,(H,23,24)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
BDBM261596
PNG
(US9708270, 100 | US9708270, 103)
Show SMILES OC(=O)C[C@@H]1CCC2(CCN(CC2)c2cc(OC3CCC3)ccc2F)OC1
Show InChI InChI=1S/C21H28FNO4/c22-18-5-4-17(27-16-2-1-3-16)13-19(18)23-10-8-21(9-11-23)7-6-15(14-26-21)12-20(24)25/h4-5,13,15-16H,1-3,6-12,14H2,(H,24,25)/t15-/m0/s1
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n/an/an/an/a 4.28E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
On the day before the measurement day, CHO cells expressing human GPR120 were plated at 10000 cells per well in a 384-well black plate (#3702, Cornin...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%