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Patent code US9708295

Compile Data Set for Download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor (F1174L)


(Homo sapiens (Human))
BDBM261689
PNG
(US9708295, 30)
Show SMILES COc1cc(cnc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-13(21-17(25)3-4-18(27)22(21)26)33-20-10-16(12-31-24(20)28)15-9-19(32-2)23(30-11-15)14-5-7-29-8-6-14/h3-5,9-13,29H,6-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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US Patent
2.60n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (F1174L)


(Homo sapiens (Human))
BDBM261711
PNG
(US9708295, 53)
Show SMILES CCOc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-4-34-20-10-22(33-8-7-30-11-14(33)2)31-13-17(20)16-9-21(25(29)32-12-16)35-15(3)23-18(26)5-6-19(28)24(23)27/h5-6,9-10,12-15,30H,4,7-8,11H2,1-3H3,(H2,29,32)/t14-,15+/m0/s1
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US Patent
3.10n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (R1275Q)


(Homo sapiens (Human))
BDBM261689
PNG
(US9708295, 30)
Show SMILES COc1cc(cnc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-13(21-17(25)3-4-18(27)22(21)26)33-20-10-16(12-31-24(20)28)15-9-19(32-2)23(30-11-15)14-5-7-29-8-6-14/h3-5,9-13,29H,6-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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US Patent
3.20n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (R1275Q)


(Homo sapiens (Human))
BDBM261711
PNG
(US9708295, 53)
Show SMILES CCOc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-4-34-20-10-22(33-8-7-30-11-14(33)2)31-13-17(20)16-9-21(25(29)32-12-16)35-15(3)23-18(26)5-6-19(28)24(23)27/h5-6,9-10,12-15,30H,4,7-8,11H2,1-3H3,(H2,29,32)/t14-,15+/m0/s1
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4.40n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM261689
PNG
(US9708295, 30)
Show SMILES COc1cc(cnc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-13(21-17(25)3-4-18(27)22(21)26)33-20-10-16(12-31-24(20)28)15-9-19(32-2)23(30-11-15)14-5-7-29-8-6-14/h3-5,9-13,29H,6-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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18.8n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM261711
PNG
(US9708295, 53)
Show SMILES CCOc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-4-34-20-10-22(33-8-7-30-11-14(33)2)31-13-17(20)16-9-21(25(29)32-12-16)35-15(3)23-18(26)5-6-19(28)24(23)27/h5-6,9-10,12-15,30H,4,7-8,11H2,1-3H3,(H2,29,32)/t14-,15+/m0/s1
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32.1n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM261686
PNG
(US9708295, 27)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-13-10-29-6-7-32(13)21-9-19(33-3)16(12-30-21)15-8-20(24(28)31-11-15)34-14(2)22-17(25)4-5-18(27)23(22)26/h4-5,8-9,11-14,29H,6-7,10H2,1-3H3,(H2,28,31)/t13-,14+/m0/s1
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35.1n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (G1269S)


(Homo sapiens (Human))
BDBM261686
PNG
(US9708295, 27)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-13-10-29-6-7-32(13)21-9-19(33-3)16(12-30-21)15-8-20(24(28)31-11-15)34-14(2)22-17(25)4-5-18(27)23(22)26/h4-5,8-9,11-14,29H,6-7,10H2,1-3H3,(H2,28,31)/t13-,14+/m0/s1
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61.3n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (G1269S)


(Homo sapiens (Human))
BDBM261689
PNG
(US9708295, 30)
Show SMILES COc1cc(cnc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-13(21-17(25)3-4-18(27)22(21)26)33-20-10-16(12-31-24(20)28)15-9-19(32-2)23(30-11-15)14-5-7-29-8-6-14/h3-5,9-13,29H,6-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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93.3n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (G1269S)


(Homo sapiens (Human))
BDBM261711
PNG
(US9708295, 53)
Show SMILES CCOc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-4-34-20-10-22(33-8-7-30-11-14(33)2)31-13-17(20)16-9-21(25(29)32-12-16)35-15(3)23-18(26)5-6-19(28)24(23)27/h5-6,9-10,12-15,30H,4,7-8,11H2,1-3H3,(H2,29,32)/t14-,15+/m0/s1
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115n/an/an/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261686
PNG
(US9708295, 27)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-13-10-29-6-7-32(13)21-9-19(33-3)16(12-30-21)15-8-20(24(28)31-11-15)34-14(2)22-17(25)4-5-18(27)23(22)26/h4-5,8-9,11-14,29H,6-7,10H2,1-3H3,(H2,28,31)/t13-,14+/m0/s1
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n/an/a 1.96n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261710
PNG
(US9708295, 52)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnc(C2=CCNCC2)c(OCCO)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-14(22-18(26)2-3-19(28)23(22)27)35-21-11-17(13-32-25(21)29)16-10-20(34-9-8-33)24(31-12-16)15-4-6-30-7-5-15/h2-4,10-14,30,33H,5-9H2,1H3,(H2,29,32)/t14-/m1/s1
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n/an/a 6.90n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261695
PNG
(US9708295, 37)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNCC1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(21-16(24)3-4-17(26)22(21)25)33-19-9-14(11-30-23(19)27)15-12-29-20(10-18(15)32-2)31-7-5-28-6-8-31/h3-4,9-13,28H,5-8H2,1-2H3,(H2,27,30)/t13-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261687
PNG
(US9708295, 28)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(C[C@@H]1C)C1CCN(C)CC1
Show InChI InChI=1S/C30H37Cl2FN6O2/c1-18-17-38(21-7-9-37(3)10-8-21)11-12-39(18)27-14-25(40-4)22(16-35-27)20-13-26(30(34)36-15-20)41-19(2)28-23(31)5-6-24(33)29(28)32/h5-6,13-16,18-19,21H,7-12,17H2,1-4H3,(H2,34,36)/t18-,19+/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261689
PNG
(US9708295, 30)
Show SMILES COc1cc(cnc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-13(21-17(25)3-4-18(27)22(21)26)33-20-10-16(12-31-24(20)28)15-9-19(32-2)23(30-11-15)14-5-7-29-8-6-14/h3-5,9-13,29H,6-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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n/an/a 9.80n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261713
PNG
(US9708295, 55)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnc(C2=CCNCC2)c(OCCN2CCOCC2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C29H32Cl2FN5O3/c1-18(26-22(30)2-3-23(32)27(26)31)40-25-15-21(17-36-29(25)33)20-14-24(39-13-10-37-8-11-38-12-9-37)28(35-16-20)19-4-6-34-7-5-19/h2-4,14-18,34H,5-13H2,1H3,(H2,33,36)/t18-/m1/s1
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n/an/a 13.1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261711
PNG
(US9708295, 53)
Show SMILES CCOc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-4-34-20-10-22(33-8-7-30-11-14(33)2)31-13-17(20)16-9-21(25(29)32-12-16)35-15(3)23-18(26)5-6-19(28)24(23)27/h5-6,9-10,12-15,30H,4,7-8,11H2,1-3H3,(H2,29,32)/t14-,15+/m0/s1
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n/an/a 13.9n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261692
PNG
(US9708295, 34)
Show SMILES COc1ccc(nc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNCC1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(20-15(24)3-4-16(26)21(20)25)33-18-11-14(12-29-23(18)27)22-17(32-2)5-6-19(30-22)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10H2,1-2H3,(H2,27,29)/t13-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261688
PNG
((R)-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-4'-m...)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(I)c2Cl)c1)C1=CCNCC1
Show InChI InChI=1S/C24H23Cl2IN4O2/c1-13(22-17(25)3-4-18(27)23(22)26)33-21-9-15(11-31-24(21)28)16-12-30-19(10-20(16)32-2)14-5-7-29-8-6-14/h3-5,9-13,29H,6-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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n/an/a 19.2n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261696
PNG
(US9708295, 38)
Show SMILES COc1cnc(cc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNCC1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(21-16(24)3-4-17(26)22(21)25)33-18-9-14(11-30-23(18)27)15-10-20(29-12-19(15)32-2)31-7-5-28-6-8-31/h3-4,9-13,28H,5-8H2,1-2H3,(H2,27,30)/t13-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261690
PNG
(US9708295, 31)
Show SMILES COc1cc(ncc1-c1cnc(N)c(OC(C)c2cc(F)ccc2C(C)(F)F)c1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C31H39F3N6O2/c1-20(24-16-22(32)5-6-26(24)31(2,33)34)42-28-15-21(18-37-30(28)35)25-19-36-29(17-27(25)41-4)40-9-7-23(8-10-40)39-13-11-38(3)12-14-39/h5-6,15-20,23H,7-14H2,1-4H3,(H2,35,37)
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n/an/a 20.8n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261683
PNG
(US9708295, 24)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(C)C[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-14-13-32(3)7-8-33(14)22-10-20(34-4)17(12-30-22)16-9-21(25(29)31-11-16)35-15(2)23-18(26)5-6-19(28)24(23)27/h5-6,9-12,14-15H,7-8,13H2,1-4H3,(H2,29,31)/t14-,15+/m0/s1
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n/an/a 22.4n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261691
PNG
(US9708295, 32)
Show SMILES COc1ccc(nc1N1CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(20-15(24)3-4-16(26)21(20)25)33-19-11-14(12-29-22(19)27)17-5-6-18(32-2)23(30-17)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10H2,1-2H3,(H2,27,29)/t13-/m1/s1
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n/an/a 27.8n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261700
PNG
(US9708295, 42)
Show SMILES COc1cc(cnc1C1CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H25Cl2FN4O2/c1-13(21-17(25)3-4-18(27)22(21)26)33-20-10-16(12-31-24(20)28)15-9-19(32-2)23(30-11-15)14-5-7-29-8-6-14/h3-4,9-14,29H,5-8H2,1-2H3,(H2,28,31)/t13-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261681
PNG
(US9708295, 22)
Show SMILES COc1cc(ncc1-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(C)C[C@@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-14-13-32(3)7-8-33(14)22-10-20(34-4)17(12-30-22)16-9-21(25(29)31-11-16)35-15(2)23-18(26)5-6-19(28)24(23)27/h5-6,9-12,14-15H,7-8,13H2,1-4H3,(H2,29,31)/t14-,15?/m0/s1
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n/an/a 38.1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261685
PNG
(US9708295, 26)
Show SMILES COc1cc(cnc1N1CCN(C)C[C@@H]1C)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-14-13-32(3)7-8-33(14)25-21(34-4)10-17(12-31-25)16-9-20(24(29)30-11-16)35-15(2)22-18(26)5-6-19(28)23(22)27/h5-6,9-12,14-15H,7-8,13H2,1-4H3,(H2,29,30)/t14-,15+/m0/s1
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n/an/a 42n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261704
PNG
(US9708295, 46)
Show SMILES COc1cc(ccc1-c1cnc(N)c(OC(C)c2cc(F)ccc2C(C)(F)F)c1)N1CCNCC1
Show InChI InChI=1S/C26H29F3N4O2/c1-16(21-13-18(27)4-7-22(21)26(2,28)29)35-24-12-17(15-32-25(24)30)20-6-5-19(14-23(20)34-3)33-10-8-31-9-11-33/h4-7,12-16,31H,8-11H2,1-3H3,(H2,30,32)
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n/an/a 44.8n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261709
PNG
(5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5'-m...)
Show SMILES COc1cc(cnc1C1=CCNCC1C)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C25H25Cl2FN4O2/c1-13-10-30-7-6-17(13)24-20(33-3)8-15(11-31-24)16-9-21(25(29)32-12-16)34-14(2)22-18(26)4-5-19(28)23(22)27/h4-6,8-9,11-14,30H,7,10H2,1-3H3,(H2,29,32)/t13?,14-/m1/s1
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n/an/a 46.8n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261684
PNG
(US9708295, 25)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(C)C[C@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-14-13-32(3)7-8-33(14)22-10-20(34-4)17(12-30-22)16-9-21(25(29)31-11-16)35-15(2)23-18(26)5-6-19(28)24(23)27/h5-6,9-12,14-15H,7-8,13H2,1-4H3,(H2,29,31)/t14-,15-/m1/s1
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n/an/a 55.1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261702
PNG
(US9708295, 44)
Show SMILES COc1ccc(nc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-13-11-29-8-9-32(13)20-7-6-18(33-3)23(31-20)15-10-19(24(28)30-12-15)34-14(2)21-16(25)4-5-17(27)22(21)26/h4-7,10,12-14,29H,8-9,11H2,1-3H3,(H2,28,30)/t13-,14+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261701
PNG
(US9708295, 43)
Show SMILES COc1ccc(nc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-13(21-16(25)3-4-17(27)22(21)26)33-20-11-15(12-30-24(20)28)18-5-6-19(32-2)23(31-18)14-7-9-29-10-8-14/h3-7,11-13,29H,8-10H2,1-2H3,(H2,28,30)/t13-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261682
PNG
(US9708295, 23)
Show SMILES COc1cc(ncc1-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(C)C[C@H]1C
Show InChI InChI=1S/C25H28Cl2FN5O2/c1-14-13-32(3)7-8-33(14)22-10-20(34-4)17(12-30-22)16-9-21(25(29)31-11-16)35-15(2)23-18(26)5-6-19(28)24(23)27/h5-6,9-12,14-15H,7-8,13H2,1-4H3,(H2,29,31)/t14-,15?/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261708
PNG
(US9708295, 50)
Show SMILES CCOc1cc(cnc1C1=CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C25H25Cl2FN4O2/c1-3-33-20-10-16(12-31-24(20)15-6-8-30-9-7-15)17-11-21(25(29)32-13-17)34-14(2)22-18(26)4-5-19(28)23(22)27/h4-6,10-14,30H,3,7-9H2,1-2H3,(H2,29,32)/t14-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261680
PNG
(US9708295, 19)
Show SMILES COc1cc(ncc1-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(C)CC1
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-14(22-17(25)4-5-18(27)23(22)26)34-20-10-15(12-30-24(20)28)16-13-29-21(11-19(16)33-3)32-8-6-31(2)7-9-32/h4-5,10-14H,6-9H2,1-3H3,(H2,28,30)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261679
PNG
(US9708295, 18)
Show SMILES COc1cc(cnc1N1CCN(C)CC1)-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-14(21-17(25)4-5-18(27)22(21)26)34-19-10-15(12-29-23(19)28)16-11-20(33-3)24(30-13-16)32-8-6-31(2)7-9-32/h4-5,10-14H,6-9H2,1-3H3,(H2,28,29)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261712
PNG
(US9708295, 54)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnc(N2CCOCC2)c(OCCN2CCOCC2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C28H32Cl2FN5O4/c1-18(25-21(29)2-3-22(31)26(25)30)40-23-14-19(16-33-27(23)32)20-15-24(39-13-6-35-4-9-37-10-5-35)28(34-17-20)36-7-11-38-12-8-36/h2-3,14-18H,4-13H2,1H3,(H2,32,33)/t18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261714
PNG
(US9708295, 56)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnc(cc1OCCN1CCOCC1)N1CCNC[C@@H]1C)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C29H35Cl2FN6O3/c1-18-15-34-5-6-38(18)26-14-24(40-12-9-37-7-10-39-11-8-37)21(17-35-26)20-13-25(29(33)36-16-20)41-19(2)27-22(30)3-4-23(32)28(27)31/h3-4,13-14,16-19,34H,5-12,15H2,1-2H3,(H2,33,36)/t18-,19+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261703
PNG
(US9708295, 45)
Show SMILES COc1c(cncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNCC1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(20-16(24)3-4-17(26)21(20)25)33-19-9-14(10-30-23(19)27)15-11-29-12-18(22(15)32-2)31-7-5-28-6-8-31/h3-4,9-13,28H,5-8H2,1-2H3,(H2,27,30)/t13-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261707
PNG
(US9708295, 49)
Show SMILES COc1cc(N2CCNCC2)c(Cl)cc1-c1cnc(N)c(OC(C)c2cc(F)ccc2C(C)(F)F)c1
Show InChI InChI=1S/C26H28ClF3N4O2/c1-15(18-11-17(28)4-5-20(18)26(2,29)30)36-24-10-16(14-33-25(24)31)19-12-21(27)22(13-23(19)35-3)34-8-6-32-7-9-34/h4-5,10-15,32H,6-9H2,1-3H3,(H2,31,33)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261697
PNG
(US9708295, 39)
Show SMILES COc1cnc(cc1N1CCNCC1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(21-15(24)3-4-16(26)22(21)25)33-19-9-14(11-30-23(19)27)17-10-18(20(32-2)12-29-17)31-7-5-28-6-8-31/h3-4,9-13,28H,5-8H2,1-2H3,(H2,27,30)/t13-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261675
PNG
(US9708295, 2)
Show SMILES COc1cc(ccc1-c1cnc(N)cc1-c1ccnn1-c1ccc(F)cc1)N1CCNCC1
Show InChI InChI=1S/C25H25FN6O/c1-33-24-14-19(31-12-10-28-11-13-31)6-7-20(24)22-16-29-25(27)15-21(22)23-8-9-30-32(23)18-4-2-17(26)3-5-18/h2-9,14-16,28H,10-13H2,1H3,(H2,27,29)
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n/an/a 136n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261694
PNG
(US9708295, 36)
Show SMILES COc1cc(nc(c1)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNCC1
Show InChI InChI=1S/C23H24Cl2FN5O2/c1-13(21-16(24)3-4-17(26)22(21)25)33-19-9-14(12-29-23(19)27)18-10-15(32-2)11-20(30-18)31-7-5-28-6-8-31/h3-4,9-13,28H,5-8H2,1-2H3,(H2,27,29)/t13-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261705
PNG
(US9708295, 47)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCOCC1
Show InChI InChI=1S/C23H23Cl2FN4O3/c1-13(21-16(24)3-4-17(26)22(21)25)33-19-9-14(11-29-23(19)27)15-12-28-20(10-18(15)31-2)30-5-7-32-8-6-30/h3-4,9-13H,5-8H2,1-2H3,(H2,27,29)/t13-/m1/s1
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n/an/a 175n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261698
PNG
(US9708295, 40)
Show SMILES COc1cc(ccc1-c1cnc(N)c(OC(C)c2cc(F)ccc2C(F)F)c1)N1CCNCC1
Show InChI InChI=1S/C25H27F3N4O2/c1-15(21-12-17(26)3-5-20(21)24(27)28)34-23-11-16(14-31-25(23)29)19-6-4-18(13-22(19)33-2)32-9-7-30-8-10-32/h3-6,11-15,24,30H,7-10H2,1-2H3,(H2,29,31)
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n/an/a 227n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261693
PNG
(US9708295, 35)
Show SMILES COc1cc(ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC(=O)C1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-12(21-15(24)3-4-16(26)22(21)25)34-18-7-13(9-30-23(18)27)14-10-29-19(8-17(14)33-2)31-6-5-28-20(32)11-31/h3-4,7-10,12H,5-6,11H2,1-2H3,(H2,27,30)(H,28,32)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261706
PNG
(US9708295, 48)
Show SMILES COc1ccc(nc1N1CCNC[C@@H]1C)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C24H26Cl2FN5O2/c1-13-11-29-8-9-32(13)24-19(33-3)7-6-18(31-24)15-10-20(23(28)30-12-15)34-14(2)21-16(25)4-5-17(27)22(21)26/h4-7,10,12-14,29H,8-9,11H2,1-3H3,(H2,28,30)/t13-,14+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261678
PNG
(US9708295, 17)
Show SMILES COc1nc(ncc1-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C25H29Cl2FN6O2/c1-14(2)33-7-9-34(10-8-33)25-31-13-17(24(32-25)35-4)16-11-20(23(29)30-12-16)36-15(3)21-18(26)5-6-19(28)22(21)27/h5-6,11-15H,7-10H2,1-4H3,(H2,29,30)
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n/an/a 396n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261674
PNG
(US9708295, 1)
Show SMILES COc1cc(ccc1-c1cnc(N)cc1-c1ccnn1-c1ccc(F)c(Cl)c1)N1CCNCC1
Show InChI InChI=1S/C25H24ClFN6O/c1-34-24-13-16(32-10-8-29-9-11-32)2-4-18(24)20-15-30-25(28)14-19(20)23-6-7-31-33(23)17-3-5-22(27)21(26)12-17/h2-7,12-15,29H,8-11H2,1H3,(H2,28,30)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261699
PNG
(US9708295, 41)
Show SMILES COc1cc(N2CCNCC2)c(Cl)cc1-c1cnc(N)c(OC(C)c2cc(F)ccc2C(F)F)c1
Show InChI InChI=1S/C25H26ClF3N4O2/c1-14(18-10-16(27)3-4-17(18)24(28)29)35-23-9-15(13-32-25(23)30)19-11-20(26)21(12-22(19)34-2)33-7-5-31-6-8-33/h3-4,9-14,24,31H,5-8H2,1-2H3,(H2,30,32)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261677
PNG
(US9708295, 16)
Show SMILES Nc1ncc(cc1COc1cccc(F)c1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H22FN5O/c21-17-2-1-3-19(9-17)27-13-15-8-14(10-24-20(15)22)16-11-25-26(12-16)18-4-6-23-7-5-18/h1-3,8-12,18,23H,4-7,13H2,(H2,22,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM261676
PNG
(US9708295, 12)
Show SMILES COc1cc(ccc1-c1cnc(N)cc1C#Cc1ccnn1Cc1ccc(Cl)c(F)c1)N1CCN(C)CC1
Show InChI InChI=1S/C29H28ClFN6O/c1-35-11-13-36(14-12-35)23-6-7-24(28(17-23)38-2)25-18-33-29(32)16-21(25)4-5-22-9-10-34-37(22)19-20-3-8-26(30)27(31)15-20/h3,6-10,15-18H,11-14,19H2,1-2H3,(H2,32,33)
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n/an/a 1.00E+3n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%