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Patent code US9708311

Compile Data Set for Download or QSAR
Found 143 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261893
PNG
(2-(6-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(Cl)cc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H24ClN3O3/c1-4-29-21-8-5-16(13-19(21)20-14-17(27)6-9-22(20)29)25-28-24-15(2)18(26(31)32)7-10-23(24)30(25)11-12-33-3/h5-10,13-14H,4,11-12H2,1-3H3,(H,31,32)
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n/an/a 4.16n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261894
PNG
(2-(8-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(cc2c2cccc(Cl)c12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H24ClN3O3/c1-4-29-21-10-8-16(14-19(21)18-6-5-7-20(27)24(18)29)25-28-23-15(2)17(26(31)32)9-11-22(23)30(25)12-13-33-3/h5-11,14H,4,12-13H2,1-3H3,(H,31,32)
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n/an/a 5.19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261752
PNG
(3-Amino-4-[(2-methoxyethyl)amino]benzoic acid | US...)
Show SMILES COCCNc1ccc(cc1N)C(O)=O
Show InChI InChI=1S/C10H14N2O3/c1-15-5-4-12-9-3-2-7(10(13)14)6-8(9)11/h2-3,6,12H,4-5,11H2,1H3,(H,13,14)
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n/an/a 5.59n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261760
PNG
(2-(9-Ethyl-5-fluoro-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(cc2c2c(F)cccc12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-20-9-7-15(13-17(20)23-18(26)5-4-6-22(23)28)24-27-19-14-16(25(30)31)8-10-21(19)29(24)11-12-32-2/h4-10,13-14H,3,11-12H2,1-2H3,(H,30,31)
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n/an/a 6.36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261864
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-4-fluoro-1-(2-methoxy...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(F)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-19-7-5-4-6-16(19)18-14-15(8-10-20(18)28)24-27-23-21(29(24)12-13-32-2)11-9-17(22(23)26)25(30)31/h4-11,14H,3,12-13H2,1-2H3,(H,30,31)
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n/an/a 6.42n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261884
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(tetrahydrofuran-2-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CCCO1)C(O)=O
Show InChI InChI=1S/C27H25N3O3/c1-2-29-23-8-4-3-7-20(23)21-14-17(9-11-24(21)29)26-28-22-15-18(27(31)32)10-12-25(22)30(26)16-19-6-5-13-33-19/h3-4,7-12,14-15,19H,2,5-6,13,16H2,1H3,(H,31,32)
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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261761
PNG
(2-(9-Ethyl-8-fluoro-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(cc2c2cccc(F)c12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-21-9-7-15(13-18(21)17-5-4-6-19(26)23(17)28)24-27-20-14-16(25(30)31)8-10-22(20)29(24)11-12-32-2/h4-10,13-14H,3,11-12H2,1-2H3,(H,30,31)
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n/an/a 10.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261759
PNG
(2-(9-Ethyl-7-fluoro-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(cc2c2ccc(F)cc12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-21-8-4-15(12-19(21)18-7-6-17(26)14-23(18)28)24-27-20-13-16(25(30)31)5-9-22(20)29(24)10-11-32-2/h4-9,12-14H,3,10-11H2,1-2H3,(H,30,31)
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n/an/a 10.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261865
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(F)c(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C26H22FN3O2/c1-2-29-20-6-4-3-5-17(20)19-13-16(9-11-21(19)29)25-28-24-22(30(25)14-15-7-8-15)12-10-18(23(24)27)26(31)32/h3-6,9-13,15H,2,7-8,14H2,1H3,(H,31,32)
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n/an/a 11.6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261795
PNG
(3-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1noc(=O)[nH]1
Show InChI InChI=1S/C26H23N5O3/c1-3-30-21-7-5-4-6-18(21)19-14-17(9-10-22(19)30)25-27-20-15-16(24-28-26(32)34-29-24)8-11-23(20)31(25)12-13-33-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,28,29,32)
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n/an/a 12.4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261785
PNG
(2-[9-(Cyclopropylmethyl)-9H-carbazol-3-yl]-1-(2-me...)
Show SMILES COCCn1c(nc2cc(ccc12)C(O)=O)-c1ccc2n(CC3CC3)c3ccccc3c2c1
Show InChI InChI=1S/C27H25N3O3/c1-33-13-12-29-25-11-9-19(27(31)32)15-22(25)28-26(29)18-8-10-24-21(14-18)20-4-2-3-5-23(20)30(24)16-17-6-7-17/h2-5,8-11,14-15,17H,6-7,12-13,16H2,1H3,(H,31,32)
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n/an/a 13.1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261794
PNG
(9-Ethyl-3-[1-(2-methoxyethyl)-5-(1H-tetrazol-5-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1nnn[nH]1
Show InChI InChI=1S/C25H23N7O/c1-3-31-21-7-5-4-6-18(21)19-14-17(9-10-22(19)31)25-26-20-15-16(24-27-29-30-28-24)8-11-23(20)32(25)12-13-33-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,27,28,29,30)
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n/an/a 13.4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261881
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-[2-(trifluoromethox...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC(F)(F)F)C(O)=O
Show InChI InChI=1S/C25H20F3N3O3/c1-2-30-20-6-4-3-5-17(20)18-13-15(7-9-21(18)30)23-29-19-14-16(24(32)33)8-10-22(19)31(23)11-12-34-25(26,27)28/h3-10,13-14H,2,11-12H2,1H3,(H,32,33)
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n/an/a 14.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261754
PNG
(4-Bromo-3-chloro-N-(cyclopropylmethyl)-2-nitroanil...)
Show SMILES [O-][N+](=O)c1c(Cl)c(Br)ccc1NCC1CC1
Show InChI InChI=1S/C10H10BrClN2O2/c11-7-3-4-8(13-5-6-1-2-6)10(9(7)12)14(15)16/h3-4,6,13H,1-2,5H2
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n/an/a 14.4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261766
PNG
(N-[(3-Chlorophenyl)sulphonyl]-2-(9-ethyl-9H-carbaz...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C31H27ClN4O4S/c1-3-35-27-10-5-4-9-24(27)25-17-20(11-13-28(25)35)30-33-26-18-21(12-14-29(26)36(30)15-16-40-2)31(37)34-41(38,39)23-8-6-7-22(32)19-23/h4-14,17-19H,3,15-16H2,1-2H3,(H,34,37)
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n/an/a 14.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261892
PNG
(2-(9-Ethyl-6-methyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(C)cc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-5-29-22-9-6-16(2)14-20(22)21-15-18(7-10-23(21)29)26-28-25-17(3)19(27(31)32)8-11-24(25)30(26)12-13-33-4/h6-11,14-15H,5,12-13H2,1-4H3,(H,31,32)
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n/an/a 15.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261815
PNG
(N-[(2,2-Dimethylpropyl)sulphonyl]-2-(9-ethyl-9H-ca...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CC(C)(C)C
Show InChI InChI=1S/C30H34N4O4S/c1-6-33-25-10-8-7-9-22(25)23-17-20(11-13-26(23)33)28-31-24-18-21(12-14-27(24)34(28)15-16-38-5)29(35)32-39(36,37)19-30(2,3)4/h7-14,17-18H,6,15-16,19H2,1-5H3,(H,32,35)
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n/an/a 16.1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261846
PNG
(2-(9-Allyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...)
Show SMILES COCCn1c(nc2cc(ccc12)C(O)=O)-c1ccc2n(CC=C)c3ccccc3c2c1
Show InChI InChI=1S/C26H23N3O3/c1-3-12-28-22-7-5-4-6-19(22)20-15-17(8-10-23(20)28)25-27-21-16-18(26(30)31)9-11-24(21)29(25)13-14-32-2/h3-11,15-16H,1,12-14H2,2H3,(H,30,31)
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n/an/a 16.5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261808
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CCOC
Show InChI InChI=1S/C28H30N4O5S/c1-4-31-24-8-6-5-7-21(24)22-17-19(9-11-25(22)31)27-29-23-18-20(10-12-26(23)32(27)13-14-36-2)28(33)30-38(34,35)16-15-37-3/h5-12,17-18H,4,13-16H2,1-3H3,(H,30,33)
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n/an/a 16.9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261803
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C32H27F3N4O5S/c1-3-38-25-9-5-4-8-22(25)23-18-20(12-14-26(23)38)30-36-24-19-21(13-15-27(24)39(30)16-17-43-2)31(40)37-45(41,42)29-11-7-6-10-28(29)44-32(33,34)35/h4-15,18-19H,3,16-17H2,1-2H3,(H,37,40)
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n/an/a 17.6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261762
PNG
(9-Ethyl-5-fluoro-9H-carbazole-3-carbaldehyde | US9...)
Show SMILES CCn1c2ccc(C=O)cc2c2c(F)cccc12
Show InChI InChI=1S/C15H12FNO/c1-2-17-13-7-6-10(9-18)8-11(13)15-12(16)4-3-5-14(15)17/h3-9H,2H2,1H3
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261888
PNG
(1-(2-Cyclopropyl-2-hydroxyethyl)-2-(9-ethyl-9H-car...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC(O)C1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O3/c1-2-29-22-6-4-3-5-19(22)20-13-17(9-11-23(20)29)26-28-21-14-18(27(32)33)10-12-24(21)30(26)15-25(31)16-7-8-16/h3-6,9-14,16,25,31H,2,7-8,15H2,1H3,(H,32,33)
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n/an/a 18.6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261756
PNG
(3-[5-Bromo-4-chloro-1-(cyclopropylmethyl)-1H-benzi...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(Cl)c(Br)ccc2n1CC1CC1
Show InChI InChI=1S/C25H21BrClN3/c1-2-29-20-6-4-3-5-17(20)18-13-16(9-11-21(18)29)25-28-24-22(12-10-19(26)23(24)27)30(25)14-15-7-8-15/h3-6,9-13,15H,2,7-8,14H2,1H3
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n/an/a 19.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261809
PNG
(N-[(2,6-Dichlorbenzyl)sulphonyl]-2-(9-ethyl-9H-car...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C32H28Cl2N4O4S/c1-3-37-28-10-5-4-7-22(28)23-17-20(11-13-29(23)37)31-35-27-18-21(12-14-30(27)38(31)15-16-42-2)32(39)36-43(40,41)19-24-25(33)8-6-9-26(24)34/h4-14,17-18H,3,15-16,19H2,1-2H3,(H,36,39)
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n/an/a 19.8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261824
PNG
(1-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbazol-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN(C)C)C(=O)NS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C33H33N5O3S/c1-5-37-29-9-7-6-8-26(29)27-20-23(12-16-30(27)37)32-34-28-21-24(13-17-31(28)38(32)19-18-36(3)4)33(39)35-42(40,41)25-14-10-22(2)11-15-25/h6-17,20-21H,5,18-19H2,1-4H3,(H,35,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261867
PNG
(1-(2-Cyclopropylethyl)-2-(9-ethyl-9H-carbazol-3-yl...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O2/c1-2-29-23-6-4-3-5-20(23)21-15-18(9-11-24(21)29)26-28-22-16-19(27(31)32)10-12-25(22)30(26)14-13-17-7-8-17/h3-6,9-12,15-17H,2,7-8,13-14H2,1H3,(H,31,32)
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n/an/a 22.1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261866
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-pyrido[2,3-b]i...)
Show SMILES CCn1c2ccc(cc2c2cccnc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C25H22N4O2/c1-2-28-21-9-7-16(12-19(21)18-4-3-11-26-24(18)28)23-27-20-13-17(25(30)31)8-10-22(20)29(23)14-15-5-6-15/h3-4,7-13,15H,2,5-6,14H2,1H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261767
PNG
(2-Chloro-5-ethyl-5H-pyrido[3,2-b]indole | US970831...)
Show SMILES CCn1c2ccccc2c2nc(Cl)ccc12
Show InChI InChI=1S/C13H11ClN2/c1-2-16-10-6-4-3-5-9(10)13-11(16)7-8-12(14)15-13/h3-8H,2H2,1H3
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n/an/a 22.8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261764
PNG
(9-(2-Methoxyethyl)-9H-carbazole-3-carbaldehyde | U...)
Show SMILES COCCn1c2ccccc2c2cc(C=O)ccc12
Show InChI InChI=1S/C16H15NO2/c1-19-9-8-17-15-5-3-2-4-13(15)14-10-12(11-18)6-7-16(14)17/h2-7,10-11H,8-9H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261883
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(oxetan-2-ylmethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CCO1)C(O)=O
Show InChI InChI=1S/C26H23N3O3/c1-2-28-22-6-4-3-5-19(22)20-13-16(7-9-23(20)28)25-27-21-14-17(26(30)31)8-10-24(21)29(25)15-18-11-12-32-18/h3-10,13-14,18H,2,11-12,15H2,1H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261796
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1cccc(C)c1
Show InChI InChI=1S/C32H30N4O4S/c1-4-35-28-11-6-5-10-25(28)26-19-22(12-14-29(26)35)31-33-27-20-23(13-15-30(27)36(31)16-17-40-3)32(37)34-41(38,39)24-9-7-8-21(2)18-24/h5-15,18-20H,4,16-17H2,1-3H3,(H,34,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261781
PNG
(3-(5-Bromo-4-fluoro-1H-benzimidazol-2-yl)-9-ethyl-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(F)c(Br)ccc2[nH]1
Show InChI InChI=1S/C21H15BrFN3/c1-2-26-17-6-4-3-5-13(17)14-11-12(7-10-18(14)26)21-24-16-9-8-15(22)19(23)20(16)25-21/h3-11H,2H2,1H3,(H,24,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261765
PNG
(9-Ethyl-6-methoxy-9H-carbazole-3-carbaldehyde | US...)
Show SMILES CCn1c2ccc(OC)cc2c2cc(C=O)ccc12
Show InChI InChI=1S/C16H15NO2/c1-3-17-15-6-4-11(10-18)8-13(15)14-9-12(19-2)5-7-16(14)17/h4-10H,3H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261782
PNG
(2-(9-Allyl-9H-carbazol-3-yl)-1-(cyclopropylmethyl)...)
Show SMILES OC(=O)c1ccc2n(CC3CC3)c(nc2c1)-c1ccc2n(CC=C)c3ccccc3c2c1
Show InChI InChI=1S/C27H23N3O2/c1-2-13-29-23-6-4-3-5-20(23)21-14-18(9-11-24(21)29)26-28-22-15-19(27(31)32)10-12-25(22)30(26)16-17-7-8-17/h2-6,9-12,14-15,17H,1,7-8,13,16H2,(H,31,32)
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n/an/a 28.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261779
PNG
(Ethyl 3-amino-4-[(3-methoxypropyl)amino]benzoate |...)
Show SMILES CCOC(=O)c1ccc(NCCCOC)c(N)c1
Show InChI InChI=1S/C13H20N2O3/c1-3-18-13(16)10-5-6-12(11(14)9-10)15-7-4-8-17-2/h5-6,9,15H,3-4,7-8,14H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261768
PNG
(Methyl 5-ethyl-5H-pyrido[3,2-b]indole-2-carboxylat...)
Show SMILES CCn1c2ccccc2c2nc(ccc12)C(=O)OC
Show InChI InChI=1S/C15H14N2O2/c1-3-17-12-7-5-4-6-10(12)14-13(17)9-8-11(16-14)15(18)19-2/h4-9H,3H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261763
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-pyrido[2,3-b]i...)
Show SMILES CCn1c2ccccc2c2cc(cnc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C25H22N4O2/c1-2-28-21-6-4-3-5-18(21)19-11-17(13-26-24(19)28)23-27-20-12-16(25(30)31)9-10-22(20)29(23)14-15-7-8-15/h3-6,9-13,15H,2,7-8,14H2,1H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261799
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C31H28N4O4S/c1-3-34-27-12-8-7-11-24(27)25-19-21(13-15-28(25)34)30-32-26-20-22(14-16-29(26)35(30)17-18-39-2)31(36)33-40(37,38)23-9-5-4-6-10-23/h4-16,19-20H,3,17-18H2,1-2H3,(H,33,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261784
PNG
(6-Chloro-9-ethyl-9H-carbazole-3-carbaldehyde and 8...)
Show SMILES CCn1c2ccc(Cl)cc2c2cc(C=O)ccc12
Show InChI InChI=1S/C15H12ClNO/c1-2-17-14-5-3-10(9-18)7-12(14)13-8-11(16)4-6-15(13)17/h3-9H,2H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261862
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(F)cc2n1CC1CC1
Show InChI InChI=1S/C26H22FN3O2/c1-2-29-22-6-4-3-5-17(22)18-11-16(9-10-23(18)29)25-28-21-12-19(26(31)32)20(27)13-24(21)30(25)14-15-7-8-15/h3-6,9-13,15H,2,7-8,14H2,1H3,(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261802
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C32H30N4O4S/c1-4-35-27-11-7-6-10-24(27)25-19-22(13-15-28(25)35)31-33-26-20-23(14-16-29(26)36(31)17-18-40-3)32(37)34-41(38,39)30-12-8-5-9-21(30)2/h5-16,19-20H,4,17-18H2,1-3H3,(H,34,37)
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n/an/a 35.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261801
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccccc1OC
Show InChI InChI=1S/C32H30N4O5S/c1-4-35-26-10-6-5-9-23(26)24-19-21(13-15-27(24)35)31-33-25-20-22(14-16-28(25)36(31)17-18-40-2)32(37)34-42(38,39)30-12-8-7-11-29(30)41-3/h5-16,19-20H,4,17-18H2,1-3H3,(H,34,37)
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n/an/a 35.9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261868
PNG
(1-(2-Methoxyethyl)-2-(9-propyl-9H-carbazol-3-yl)-1...)
Show SMILES CCCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H25N3O3/c1-3-12-28-22-7-5-4-6-19(22)20-15-17(8-10-23(20)28)25-27-21-16-18(26(30)31)9-11-24(21)29(25)13-14-32-2/h4-11,15-16H,3,12-14H2,1-2H3,(H,30,31)
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n/an/a 36.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261817
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1ncccc1C
Show InChI InChI=1S/C32H31N5O4S/c1-4-36-28-10-6-5-9-24(28)25-18-22(11-13-29(25)36)31-34-26-19-23(12-14-30(26)37(31)16-17-41-3)32(38)35-42(39,40)20-27-21(2)8-7-15-33-27/h5-15,18-19H,4,16-17,20H2,1-3H3,(H,35,38)
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n/an/a 36.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261816
PNG
(N-[(2-Chloro-6-methylbenzyl)sulphonyl]-2-(9-ethyl-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1c(C)cccc1Cl
Show InChI InChI=1S/C33H31ClN4O4S/c1-4-37-29-11-6-5-9-24(29)25-18-22(12-14-30(25)37)32-35-28-19-23(13-15-31(28)38(32)16-17-42-3)33(39)36-43(40,41)20-26-21(2)8-7-10-27(26)34/h5-15,18-19H,4,16-17,20H2,1-3H3,(H,36,39)
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n/an/a 36.9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261783
PNG
(1-(Cyclopropylmethyl)-2-(9-methyl-9H-carbazol-3-yl...)
Show SMILES Cn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C25H21N3O2/c1-27-21-5-3-2-4-18(21)19-12-16(8-10-22(19)27)24-26-20-13-17(25(29)30)9-11-23(20)28(24)14-15-6-7-15/h2-5,8-13,15H,6-7,14H2,1H3,(H,29,30)
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n/an/a 39.4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261825
PNG
(US9708311, 76 | [2-(9-Ethyl-9H-carbazol-3-yl)-1-(2...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)N1CCCC1
Show InChI InChI=1S/C29H30N4O2/c1-3-32-25-9-5-4-8-22(25)23-18-20(10-12-26(23)32)28-30-24-19-21(29(34)31-14-6-7-15-31)11-13-27(24)33(28)16-17-35-2/h4-5,8-13,18-19H,3,6-7,14-17H2,1-2H3
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n/an/a 41.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261780
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-N,1-bis(2-methoxyethy...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NCCOC
Show InChI InChI=1S/C28H30N4O3/c1-4-31-24-8-6-5-7-21(24)22-17-19(9-11-25(22)31)27-30-23-18-20(28(33)29-13-15-34-2)10-12-26(23)32(27)14-16-35-3/h5-12,17-18H,4,13-16H2,1-3H3,(H,29,33)
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n/an/a 42.8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261869
PNG
(1-(2-Methoxyethyl)-2-[9-(prop-2-yn-1-yl)-9H-carbaz...)
Show SMILES COCCn1c(nc2cc(ccc12)C(O)=O)-c1ccc2n(CC#C)c3ccccc3c2c1
Show InChI InChI=1S/C26H21N3O3/c1-3-12-28-22-7-5-4-6-19(22)20-15-17(8-10-23(20)28)25-27-21-16-18(26(30)31)9-11-24(21)29(25)13-14-32-2/h1,4-11,15-16H,12-14H2,2H3,(H,30,31)
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n/an/a 43.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261856
PNG
(5-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1n[nH]c(=O)o1
Show InChI InChI=1S/C26H23N5O3/c1-3-30-21-7-5-4-6-18(21)19-14-16(8-10-22(19)30)24-27-20-15-17(25-28-29-26(32)34-25)9-11-23(20)31(24)12-13-33-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,29,32)
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n/an/a 43.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261826
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H25F3N4O2/c1-3-33-22-7-5-4-6-19(22)20-14-17(8-10-23(20)33)25-32-21-15-18(26(35)31-16-27(28,29)30)9-11-24(21)34(25)12-13-36-2/h4-11,14-15H,3,12-13,16H2,1-2H3,(H,31,35)
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n/an/a 49.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261874
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(oxetan-3-ylmethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1COC1)C(O)=O
Show InChI InChI=1S/C26H23N3O3/c1-2-28-22-6-4-3-5-19(22)20-11-17(7-9-23(20)28)25-27-21-12-18(26(30)31)8-10-24(21)29(25)13-16-14-32-15-16/h3-12,16H,2,13-15H2,1H3,(H,30,31)
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n/an/a 51.5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261792
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-6-methoxy-9H-carb...)
Show SMILES CCn1c2ccc(OC)cc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O3/c1-3-29-23-9-6-17(12-20(23)21-14-19(33-2)8-11-24(21)29)26-28-22-13-18(27(31)32)7-10-25(22)30(26)15-16-4-5-16/h6-14,16H,3-5,15H2,1-2H3,(H,31,32)
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n/an/a 54.6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261863
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-6-fluoro-1-(2-methoxy...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(F)cc2n1CCOC
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-21-7-5-4-6-16(21)17-12-15(8-9-22(17)28)24-27-20-13-18(25(30)31)19(26)14-23(20)29(24)10-11-32-2/h4-9,12-14H,3,10-11H2,1-2H3,(H,30,31)
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n/an/a 59.5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261798
PNG
(N-[(4-Chlorophenyl)sulphonyl]-2-(9-ethyl-9H-carbaz...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H27ClN4O4S/c1-3-35-27-7-5-4-6-24(27)25-18-20(8-14-28(25)35)30-33-26-19-21(9-15-29(26)36(30)16-17-40-2)31(37)34-41(38,39)23-12-10-22(32)11-13-23/h4-15,18-19H,3,16-17H2,1-2H3,(H,34,37)
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n/an/a 61.5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261871
PNG
(1-(Cyclopropylmethyl)-2-(9-propyl-9H-carbazol-3-yl...)
Show SMILES CCCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O2/c1-2-13-29-23-6-4-3-5-20(23)21-14-18(9-11-24(21)29)26-28-22-15-19(27(31)32)10-12-25(22)30(26)16-17-7-8-17/h3-6,9-12,14-15,17H,2,7-8,13,16H2,1H3,(H,31,32)
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n/an/a 63n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261855
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H25N3O3/c1-4-28-21-8-6-5-7-19(21)20-15-17(9-11-22(20)28)25-27-24-16(2)18(26(30)31)10-12-23(24)29(25)13-14-32-3/h5-12,15H,4,13-14H2,1-3H3,(H,30,31)
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n/an/a 64.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261854
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(OC)c(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O3/c1-3-29-21-7-5-4-6-18(21)20-14-17(10-12-22(20)29)26-28-24-23(30(26)15-16-8-9-16)13-11-19(27(31)32)25(24)33-2/h4-7,10-14,16H,3,8-9,15H2,1-2H3,(H,31,32)
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n/an/a 64.4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261771
PNG
(9-Ethyl-9H-pyrido[2,3-b]indole-3-carbaldehyde | US...)
Show SMILES CCn1c2ccccc2c2cc(C=O)cnc12
Show InChI InChI=1S/C14H12N2O/c1-2-16-13-6-4-3-5-11(13)12-7-10(9-17)8-15-14(12)16/h3-9H,2H2,1H3
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n/an/a 65.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261829
PNG
(Azetidin-1-yl[1-(cyclopropylmethyl)-2-(9-ethyl-9H-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)N1CCC1
Show InChI InChI=1S/C29H28N4O/c1-2-32-25-7-4-3-6-22(25)23-16-20(10-12-26(23)32)28-30-24-17-21(29(34)31-14-5-15-31)11-13-27(24)33(28)18-19-8-9-19/h3-4,6-7,10-13,16-17,19H,2,5,8-9,14-15,18H2,1H3
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n/an/a 68.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261757
PNG
(Methyl 3-amino-4-[(cyclopropylmethyl)amino]-2-meth...)
Show SMILES COC(=O)c1ccc(NCC2CC2)c(N)c1C
Show InChI InChI=1S/C13H18N2O2/c1-8-10(13(16)17-2)5-6-11(12(8)14)15-7-9-3-4-9/h5-6,9,15H,3-4,7,14H2,1-2H3
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n/an/a 71.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261827
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C31H35N5O3/c1-3-35-27-7-5-4-6-24(27)25-20-22(8-10-28(25)35)30-33-26-21-23(9-11-29(26)36(30)16-17-38-2)31(37)32-12-13-34-14-18-39-19-15-34/h4-11,20-21H,3,12-19H2,1-2H3,(H,32,37)
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n/an/a 74.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261789
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)C1(C)CC1
Show InChI InChI=1S/C29H30N4O4S/c1-4-32-24-8-6-5-7-21(24)22-17-19(9-11-25(22)32)27-30-23-18-20(10-12-26(23)33(27)15-16-37-3)28(34)31-38(35,36)29(2)13-14-29/h5-12,17-18H,4,13-16H2,1-3H3,(H,31,34)
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n/an/a 78.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261821
PNG
(1-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbazol-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN(C)C)C(O)=O
Show InChI InChI=1S/C26H26N4O2/c1-4-29-22-8-6-5-7-19(22)20-15-17(9-11-23(20)29)25-27-21-16-18(26(31)32)10-12-24(21)30(25)14-13-28(2)3/h5-12,15-16H,4,13-14H2,1-3H3,(H,31,32)
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n/an/a 82.5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261774
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)N(C)C
Show InChI InChI=1S/C28H28N4O/c1-4-31-24-8-6-5-7-21(24)22-15-19(11-13-25(22)31)27-29-23-16-20(28(33)30(2)3)12-14-26(23)32(27)17-18-9-10-18/h5-8,11-16,18H,4,9-10,17H2,1-3H3
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n/an/a 86.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261823
PNG
(N-(Cyclopropylsulphonyl)-1-[2-(dimethylamino)ethyl...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN(C)C)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C29H31N5O3S/c1-4-33-25-8-6-5-7-22(25)23-17-19(9-13-26(23)33)28-30-24-18-20(29(35)31-38(36,37)21-11-12-21)10-14-27(24)34(28)16-15-32(2)3/h5-10,13-14,17-18,21H,4,11-12,15-16H2,1-3H3,(H,31,35)
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n/an/a 87.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261875
PNG
(2-[9-(Cyclobutylmethyl)-9H-carbazol-3-yl]-1-(2-met...)
Show SMILES COCCn1c(nc2cc(ccc12)C(O)=O)-c1ccc2n(CC3CCC3)c3ccccc3c2c1
Show InChI InChI=1S/C28H27N3O3/c1-34-14-13-30-26-12-10-20(28(32)33)16-23(26)29-27(30)19-9-11-25-22(15-19)21-7-2-3-8-24(21)31(25)17-18-5-4-6-18/h2-3,7-12,15-16,18H,4-6,13-14,17H2,1H3,(H,32,33)
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n/an/a 94.3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261800
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C35H30N4O4S/c1-3-38-31-11-7-6-10-28(31)29-21-25(13-16-32(29)38)34-36-30-22-26(14-17-33(30)39(34)18-19-43-2)35(40)37-44(41,42)27-15-12-23-8-4-5-9-24(23)20-27/h4-17,20-22H,3,18-19H2,1-2H3,(H,37,40)
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n/an/a 95.5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261790
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NC
Show InChI InChI=1S/C26H26N4O2/c1-4-29-22-8-6-5-7-19(22)20-15-17(9-11-23(20)29)25-28-21-16-18(26(31)27-2)10-12-24(21)30(25)13-14-32-3/h5-12,15-16H,4,13-14H2,1-3H3,(H,27,31)
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n/an/a 96.7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261797
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C32H30N4O4S/c1-4-35-28-8-6-5-7-25(28)26-19-22(11-15-29(26)35)31-33-27-20-23(12-16-30(27)36(31)17-18-40-3)32(37)34-41(38,39)24-13-9-21(2)10-14-24/h5-16,19-20H,4,17-18H2,1-3H3,(H,34,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261872
PNG
(1-[(2,2-Dimethylcyclopropyl)methyl]-2-(9-ethyl-9H-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1(C)C)C(O)=O
Show InChI InChI=1S/C28H27N3O2/c1-4-30-23-8-6-5-7-20(23)21-13-17(9-11-24(21)30)26-29-22-14-18(27(32)33)10-12-25(22)31(26)16-19-15-28(19,2)3/h5-14,19H,4,15-16H2,1-3H3,(H,32,33)
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n/an/a 100n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261770
PNG
(9-Ethyl-9H-pyrido[2,3-b]indole-3-carbonitrile | US...)
Show SMILES CCn1c2ccccc2c2cc(cnc12)C#N
Show InChI InChI=1S/C14H11N3/c1-2-17-13-6-4-3-5-11(13)12-7-10(8-15)9-16-14(12)17/h3-7,9H,2H2,1H3
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n/an/a 103n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261828
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C32H35N5O2/c1-2-36-28-6-4-3-5-25(28)26-19-23(9-11-29(26)36)31-34-27-20-24(10-12-30(27)37(31)21-22-7-8-22)32(38)33-13-14-35-15-17-39-18-16-35/h3-6,9-12,19-20,22H,2,7-8,13-18,21H2,1H3,(H,33,38)
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n/an/a 106n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261879
PNG
(9-Ethyl-3-[1-methyl-5-(1H-1,2,3-triazol-1-yl)-1H-b...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)-n1ccnn1
Show InChI InChI=1S/C24H20N6/c1-3-29-21-7-5-4-6-18(21)19-14-16(8-10-22(19)29)24-26-20-15-17(30-13-12-25-27-30)9-11-23(20)28(24)2/h4-15H,3H2,1-2H3
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n/an/a 111n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261848
PNG
(1-(2-Methoxyethyl)-2-[9-(2-methoxyethyl)-9H-carbaz...)
Show SMILES COCCn1c(nc2cc(ccc12)C(O)=O)-c1ccc2n(CCOC)c3ccccc3c2c1
Show InChI InChI=1S/C26H25N3O4/c1-32-13-11-28-22-6-4-3-5-19(22)20-15-17(7-9-23(20)28)25-27-21-16-18(26(30)31)8-10-24(21)29(25)12-14-33-2/h3-10,15-16H,11-14H2,1-2H3,(H,30,31)
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n/an/a 112n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261840
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-hydroxyethyl)-1H...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCO)C(O)=O
Show InChI InChI=1S/C24H21N3O3/c1-2-26-20-6-4-3-5-17(20)18-13-15(7-9-21(18)26)23-25-19-14-16(24(29)30)8-10-22(19)27(23)11-12-28/h3-10,13-14,28H,2,11-12H2,1H3,(H,29,30)
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n/an/a 113n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261776
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C28H25F3N4O/c1-2-34-23-6-4-3-5-20(23)21-13-18(9-11-24(21)34)26-33-22-14-19(27(36)32-16-28(29,30)31)10-12-25(22)35(26)15-17-7-8-17/h3-6,9-14,17H,2,7-8,15-16H2,1H3,(H,32,36)
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n/an/a 117n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261812
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1ccc(C)cn1
Show InChI InChI=1S/C31H29N5O4S/c1-4-35-26-8-6-5-7-23(26)24-17-21(10-12-27(24)35)30-33-25-18-22(11-13-28(25)36(30)15-16-40-3)31(37)34-41(38,39)29-14-9-20(2)19-32-29/h5-14,17-19H,4,15-16H2,1-3H3,(H,34,37)
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n/an/a 117n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261804
PNG
(N-(Benzylsulphonyl)-2-(9-ethyl-9H-carbazol-3-yl)-1...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C32H30N4O4S/c1-3-35-28-12-8-7-11-25(28)26-19-23(13-15-29(26)35)31-33-27-20-24(14-16-30(27)36(31)17-18-40-2)32(37)34-41(38,39)21-22-9-5-4-6-10-22/h4-16,19-20H,3,17-18,21H2,1-2H3,(H,34,37)
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n/an/a 117n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261877
PNG
(5-{1-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbaz...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN(C)C)-c1n[nH]c(=O)o1
Show InChI InChI=1S/C27H26N6O2/c1-4-32-22-8-6-5-7-19(22)20-15-17(9-11-23(20)32)25-28-21-16-18(26-29-30-27(34)35-26)10-12-24(21)33(25)14-13-31(2)3/h5-12,15-16H,4,13-14H2,1-3H3,(H,30,34)
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n/an/a 118n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261858
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-beta-carbolin-...)
Show SMILES CCn1c2ccc(cc2c2ccncc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C25H22N4O2/c1-2-28-21-7-5-16(11-19(21)18-9-10-26-13-23(18)28)24-27-20-12-17(25(30)31)6-8-22(20)29(24)14-15-3-4-15/h5-13,15H,2-4,14H2,1H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261832
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N,...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)N(C)C
Show InChI InChI=1S/C27H28N4O2/c1-5-30-23-9-7-6-8-20(23)21-16-18(10-12-24(21)30)26-28-22-17-19(27(32)29(2)3)11-13-25(22)31(26)14-15-33-4/h6-13,16-17H,5,14-15H2,1-4H3
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n/an/a 122n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261777
PNG
(4-{[1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)N1CCNC(=O)C1
Show InChI InChI=1S/C30H29N5O2/c1-2-34-25-6-4-3-5-22(25)23-15-20(9-11-26(23)34)29-32-24-16-21(30(37)33-14-13-31-28(36)18-33)10-12-27(24)35(29)17-19-7-8-19/h3-6,9-12,15-16,19H,2,7-8,13-14,17-18H2,1H3,(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261830
PNG
(US9708311, 81 | [2-(9-Ethyl-9H-carbazol-3-yl)-1-(2...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)N1CCOCC1
Show InChI InChI=1S/C29H30N4O3/c1-3-32-25-7-5-4-6-22(25)23-18-20(8-10-26(23)32)28-30-24-19-21(29(34)31-12-16-36-17-13-31)9-11-27(24)33(28)14-15-35-2/h4-11,18-19H,3,12-17H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261814
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1ccccc1OC(F)(F)F
Show InChI InChI=1S/C33H29F3N4O5S/c1-3-39-27-10-6-5-9-24(27)25-18-21(12-14-28(25)39)31-37-26-19-22(13-15-29(26)40(31)16-17-44-2)32(41)38-46(42,43)20-23-8-4-7-11-30(23)45-33(34,35)36/h4-15,18-19H,3,16-17,20H2,1-2H3,(H,38,41)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261831
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(N)=O
Show InChI InChI=1S/C25H24N4O2/c1-3-28-21-7-5-4-6-18(21)19-14-17(9-10-22(19)28)25-27-20-15-16(24(26)30)8-11-23(20)29(25)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H2,26,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261885
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-[(2R)-2-hydroxy-3-m...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C[C@@H](O)COC)C(O)=O
Show InChI InChI=1S/C26H25N3O4/c1-3-28-22-7-5-4-6-19(22)20-12-16(8-10-23(20)28)25-27-21-13-17(26(31)32)9-11-24(21)29(25)14-18(30)15-33-2/h4-13,18,30H,3,14-15H2,1-2H3,(H,31,32)/t18-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261813
PNG
(N-[(4-Chlorobenzyl)sulphonyl]-2-(9-ethyl-9H-carbaz...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C32H29ClN4O4S/c1-3-36-28-7-5-4-6-25(28)26-18-22(10-14-29(26)36)31-34-27-19-23(11-15-30(27)37(31)16-17-41-2)32(38)35-42(39,40)20-21-8-12-24(33)13-9-21/h4-15,18-19H,3,16-17,20H2,1-2H3,(H,35,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261772
PNG
(US9708311, 23 | [1-(Cyclopropylmethyl)-2-(9-ethyl-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)N1CC(O)C1
Show InChI InChI=1S/C29H28N4O2/c1-2-32-25-6-4-3-5-22(25)23-13-19(9-11-26(23)32)28-30-24-14-20(29(35)31-16-21(34)17-31)10-12-27(24)33(28)15-18-7-8-18/h3-6,9-14,18,21,34H,2,7-8,15-17H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261833
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)N(C)S(C)(=O)=O
Show InChI InChI=1S/C27H28N4O4S/c1-5-30-23-9-7-6-8-20(23)21-16-18(10-12-24(21)30)26-28-22-17-19(27(32)29(2)36(4,33)34)11-13-25(22)31(26)14-15-35-3/h6-13,16-17H,5,14-15H2,1-4H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261818
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CCc1cccc(OC)c1
Show InChI InChI=1S/C34H34N4O5S/c1-4-37-30-11-6-5-10-27(30)28-21-24(12-14-31(28)37)33-35-29-22-25(13-15-32(29)38(33)17-18-42-2)34(39)36-44(40,41)19-16-23-8-7-9-26(20-23)43-3/h5-15,20-22H,4,16-19H2,1-3H3,(H,36,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261850
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(3-methoxypropyl)-1...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCCOC)C(O)=O
Show InChI InChI=1S/C26H25N3O3/c1-3-28-22-8-5-4-7-19(22)20-15-17(9-11-23(20)28)25-27-21-16-18(26(30)31)10-12-24(21)29(25)13-6-14-32-2/h4-5,7-12,15-16H,3,6,13-14H2,1-2H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261810
PNG
(N-{[2-(2-Chlorophenyl)ethyl]sulphonyl}-2-(9-ethyl-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CCc1ccccc1Cl
Show InChI InChI=1S/C33H31ClN4O4S/c1-3-37-29-11-7-5-9-25(29)26-20-23(12-14-30(26)37)32-35-28-21-24(13-15-31(28)38(32)17-18-42-2)33(39)36-43(40,41)19-16-22-8-4-6-10-27(22)34/h4-15,20-21H,3,16-19H2,1-2H3,(H,36,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261807
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-N-[(4-fluorobenzyl)su...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C32H29FN4O4S/c1-3-36-28-7-5-4-6-25(28)26-18-22(10-14-29(26)36)31-34-27-19-23(11-15-30(27)37(31)16-17-41-2)32(38)35-42(39,40)20-21-8-12-24(33)13-9-21/h4-15,18-19H,3,16-17,20H2,1-2H3,(H,35,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261751
PNG
(Methyl 2-(9-ethyl-9H-carbazol-3-yl)-1-(2-methoxyet...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)OC
Show InChI InChI=1S/C26H25N3O3/c1-4-28-22-8-6-5-7-19(22)20-15-17(9-11-23(20)28)25-27-21-16-18(26(30)32-3)10-12-24(21)29(25)13-14-31-2/h5-12,15-16H,4,13-14H2,1-3H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261891
PNG
(1-[(2S)-1,4-Dioxan-2-ylmethyl]-2-(9-ethyl-9H-carba...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C[C@H]1COCCO1)C(O)=O
Show InChI InChI=1S/C27H25N3O4/c1-2-29-23-6-4-3-5-20(23)21-13-17(7-9-24(21)29)26-28-22-14-18(27(31)32)8-10-25(22)30(26)15-19-16-33-11-12-34-19/h3-10,13-14,19H,2,11-12,15-16H2,1H3,(H,31,32)/t19-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261775
PNG
(3-[5-Bromo-1-(2-methoxyethyl)-1H-benzimidazol-2-yl...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(Br)ccc2n1CCOC
Show InChI InChI=1S/C24H22BrN3O/c1-3-27-21-7-5-4-6-18(21)19-14-16(8-10-22(19)27)24-26-20-15-17(25)9-11-23(20)28(24)12-13-29-2/h4-11,14-15H,3,12-13H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261859
PNG
(1-(Cyclopropylmethyl)-2-(5-ethyl-5H-pyrido[4,3-b]i...)
Show SMILES CCn1c2ccncc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C25H22N4O2/c1-2-28-21-7-5-16(11-18(21)19-13-26-10-9-22(19)28)24-27-20-12-17(25(30)31)6-8-23(20)29(24)14-15-3-4-15/h5-13,15H,2-4,14H2,1H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261811
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C33H29F3N4O4S/c1-3-39-28-7-5-4-6-25(28)26-18-22(10-14-29(26)39)31-37-27-19-23(11-15-30(27)40(31)16-17-44-2)32(41)38-45(42,43)20-21-8-12-24(13-9-21)33(34,35)36/h4-15,18-19H,3,16-17,20H2,1-2H3,(H,38,41)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261844
PNG
(2-(9-Ethyl-9H-carbazol-3-y1)-1-methyl-1 H-benzimid...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)C(O)=O
Show InChI InChI=1S/C23H19N3O2/c1-3-26-19-7-5-4-6-16(19)17-12-14(8-10-20(17)26)22-24-18-13-15(23(27)28)9-11-21(18)25(22)2/h4-13H,3H2,1-2H3,(H,27,28)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261836
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C31H35N5O2/c1-3-35-27-9-5-4-8-24(27)25-20-22(10-12-28(25)35)30-33-26-21-23(11-13-29(26)36(30)18-19-38-2)31(37)32-14-17-34-15-6-7-16-34/h4-5,8-13,20-21H,3,6-7,14-19H2,1-2H3,(H,32,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261778
PNG
(Ethyl 3-amino-4-[(2-methoxyethyl)amino]benzoate | ...)
Show SMILES CCOC(=O)c1ccc(NCCOC)c(N)c1
Show InChI InChI=1S/C12H18N2O3/c1-3-17-12(15)9-4-5-11(10(13)8-9)14-6-7-16-2/h4-5,8,14H,3,6-7,13H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261805
PNG
(N-{[2-(3-Chlorophenyl)ethyl]sulphonyl}-2-(9-ethyl-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CCc1cccc(Cl)c1
Show InChI InChI=1S/C33H31ClN4O4S/c1-3-37-29-10-5-4-9-26(29)27-20-23(11-13-30(27)37)32-35-28-21-24(12-14-31(28)38(32)16-17-42-2)33(39)36-43(40,41)18-15-22-7-6-8-25(34)19-22/h4-14,19-21H,3,15-18H2,1-2H3,(H,36,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261791
PNG
(2-(5-Ethyl-5H-pyrido[3,2-b]indol-2-yl)-1-(2-methox...)
Show SMILES CCn1c2ccccc2c2nc(ccc12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C24H22N4O3/c1-3-27-19-7-5-4-6-16(19)22-21(27)11-9-17(25-22)23-26-18-14-15(24(29)30)8-10-20(18)28(23)12-13-31-2/h4-11,14H,3,12-13H2,1-2H3,(H,29,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261806
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CCc1ccccc1C
Show InChI InChI=1S/C34H34N4O4S/c1-4-37-30-12-8-7-11-27(30)28-21-25(13-15-31(28)37)33-35-29-22-26(14-16-32(29)38(33)18-19-42-3)34(39)36-43(40,41)20-17-24-10-6-5-9-23(24)2/h5-16,21-22H,4,17-20H2,1-3H3,(H,36,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261835
PNG
(N-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbazol-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NCCN(C)C
Show InChI InChI=1S/C29H33N5O2/c1-5-33-25-9-7-6-8-22(25)23-18-20(10-12-26(23)33)28-31-24-19-21(29(35)30-14-15-32(2)3)11-13-27(24)34(28)16-17-36-4/h6-13,18-19H,5,14-17H2,1-4H3,(H,30,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261890
PNG
(1-[(2R)-1,4-Dioxan-2-ylmethyl]-2-(9-ethyl-9H-carba...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C[C@@H]1COCCO1)C(O)=O
Show InChI InChI=1S/C27H25N3O4/c1-2-29-23-6-4-3-5-20(23)21-13-17(7-9-24(21)29)26-28-22-14-18(27(31)32)8-10-25(22)30(26)15-19-16-33-11-12-34-19/h3-10,13-14,19H,2,11-12,15-16H2,1H3,(H,31,32)/t19-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261876
PNG
(2-[9-(Cyclobutylmethyl)-9H-carbazol-3-yl]-1-(cyclo...)
Show SMILES OC(=O)c1ccc2n(CC3CC3)c(nc2c1)-c1ccc2n(CC3CCC3)c3ccccc3c2c1
Show InChI InChI=1S/C29H27N3O2/c33-29(34)21-11-13-27-24(15-21)30-28(32(27)17-19-8-9-19)20-10-12-26-23(14-20)22-6-1-2-7-25(22)31(26)16-18-4-3-5-18/h1-2,6-7,10-15,18-19H,3-5,8-9,16-17H2,(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261878
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)S(N)(=O)=O
Show InChI InChI=1S/C24H24N4O3S/c1-3-27-21-7-5-4-6-18(21)19-14-16(8-10-22(19)27)24-26-20-15-17(32(25,29)30)9-11-23(20)28(24)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H2,25,29,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261750
PNG
(Ethyl 4-[(2-methoxyethyl)amino]-3-nitrobenzoate | ...)
Show SMILES CCOC(=O)c1ccc(NCCOC)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C12H16N2O5/c1-3-19-12(15)9-4-5-10(13-6-7-18-2)11(8-9)14(16)17/h4-5,8,13H,3,6-7H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261887
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-[2-(methylsulphonyl...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCS(C)(=O)=O)C(O)=O
Show InChI InChI=1S/C25H23N3O4S/c1-3-27-21-7-5-4-6-18(21)19-14-16(8-10-22(19)27)24-26-20-15-17(25(29)30)9-11-23(20)28(24)12-13-33(2,31)32/h4-11,14-15H,3,12-13H2,1-2H3,(H,29,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261773
PNG
(Ethyl 3-amino-4[(cyclopropylmethyl)amino]benzoate ...)
Show SMILES CCOC(=O)c1ccc(NCC2CC2)c(N)c1
Show InChI InChI=1S/C13H18N2O2/c1-2-17-13(16)10-5-6-12(11(14)7-10)15-8-9-3-4-9/h5-7,9,15H,2-4,8,14H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261886
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-[(2S)-2-hydroxy-3-m...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C[C@H](O)COC)C(O)=O
Show InChI InChI=1S/C26H25N3O4/c1-3-28-22-7-5-4-6-19(22)20-12-16(8-10-23(20)28)25-27-21-13-17(26(31)32)9-11-24(21)29(25)14-18(30)15-33-2/h4-13,18,30H,3,14-15H2,1-2H3,(H,31,32)/t18-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261822
PNG
(1-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbazol-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN(C)C)C(=O)NC
Show InChI InChI=1S/C27H29N5O/c1-5-31-23-9-7-6-8-20(23)21-16-18(10-12-24(21)31)26-29-22-17-19(27(33)28-2)11-13-25(22)32(26)15-14-30(3)4/h6-13,16-17H,5,14-15H2,1-4H3,(H,28,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261753
PNG
(Methyl 1-(cyclopropylmethyl)-2-(9-ethyl-9H-carbazo...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)OC
Show InChI InChI=1S/C27H25N3O2/c1-3-29-23-7-5-4-6-20(23)21-14-18(10-12-24(21)29)26-28-22-15-19(27(31)32-2)11-13-25(22)30(26)16-17-8-9-17/h4-7,10-15,17H,3,8-9,16H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261847
PNG
(Ethyl 1-(2-methoxyethyl)-2-[9-(2-methoxyethyl)-9H-...)
Show SMILES CCOC(=O)c1ccc2n(CCOC)c(nc2c1)-c1ccc2n(CCOC)c3ccccc3c2c1
Show InChI InChI=1S/C28H29N3O4/c1-4-35-28(32)20-10-12-26-23(18-20)29-27(31(26)14-16-34-3)19-9-11-25-22(17-19)21-7-5-6-8-24(21)30(25)13-15-33-2/h5-12,17-18H,4,13-16H2,1-3H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261793
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C#N
Show InChI InChI=1S/C25H22N4O/c1-3-28-22-7-5-4-6-19(22)20-15-18(9-11-23(20)28)25-27-21-14-17(16-26)8-10-24(21)29(25)12-13-30-2/h4-11,14-15H,3,12-13H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261857
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-pyrido[2,3-b]i...)
Show SMILES CCn1c2ccccc2c2cc(cnc12)-c1nc2c(C)c(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C26H24N4O2/c1-3-29-21-7-5-4-6-19(21)20-12-17(13-27-25(20)29)24-28-23-15(2)18(26(31)32)10-11-22(23)30(24)14-16-8-9-16/h4-7,10-13,16H,3,8-9,14H2,1-2H3,(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261873
PNG
(Ethyl 2-(9-ethyl-9H-carbazol-3-yl)-1-(oxetan-3-ylm...)
Show SMILES CCOC(=O)c1ccc2n(CC3COC3)c(nc2c1)-c1ccc2n(CC)c3ccccc3c2c1
Show InChI InChI=1S/C28H27N3O3/c1-3-30-24-8-6-5-7-21(24)22-13-19(9-11-25(22)30)27-29-23-14-20(28(32)34-4-2)10-12-26(23)31(27)15-18-16-33-17-18/h5-14,18H,3-4,15-17H2,1-2H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261882
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-1-methyl-9H-beta-...)
Show SMILES CCn1c2ccccc2c2cc(nc(C)c12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C26H24N4O2/c1-3-29-22-7-5-4-6-18(22)19-13-21(27-15(2)24(19)29)25-28-20-12-17(26(31)32)10-11-23(20)30(25)14-16-8-9-16/h4-7,10-13,16H,3,8-9,14H2,1-2H3,(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261889
PNG
(1-[(2S)-2,3-Dihydroxypropyl]-2-(9-ethyl-9H-carbazo...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC(O)CO)C(O)=O
Show InChI InChI=1S/C25H23N3O4/c1-2-27-21-6-4-3-5-18(21)19-11-15(7-9-22(19)27)24-26-20-12-16(25(31)32)8-10-23(20)28(24)13-17(30)14-29/h3-12,17,29-30H,2,13-14H2,1H3,(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261861
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-6-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(C)cc2n1CCOC
Show InChI InChI=1S/C26H25N3O3/c1-4-28-22-8-6-5-7-18(22)20-14-17(9-10-23(20)28)25-27-21-15-19(26(30)31)16(2)13-24(21)29(25)11-12-32-3/h5-10,13-15H,4,11-12H2,1-3H3,(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261769
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-N-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C34H31F3N4O4S/c1-3-40-29-7-5-4-6-26(29)27-20-23(10-14-30(27)40)32-38-28-21-24(11-15-31(28)41(32)17-18-45-2)33(42)39-46(43,44)19-16-22-8-12-25(13-9-22)34(35,36)37/h4-15,20-21H,3,16-19H2,1-2H3,(H,39,42)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261843
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-isopropyl-1H-benzim...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C(C)C)C(O)=O
Show InChI InChI=1S/C25H23N3O2/c1-4-27-21-8-6-5-7-18(21)19-13-16(9-11-22(19)27)24-26-20-14-17(25(29)30)10-12-23(20)28(24)15(2)3/h5-15H,4H2,1-3H3,(H,29,30)
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n/an/a 733n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261787
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-[2-(pyrrolidin-1-yl...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C28H28N4O2/c1-2-31-24-8-4-3-7-21(24)22-17-19(9-11-25(22)31)27-29-23-18-20(28(33)34)10-12-26(23)32(27)16-15-30-13-5-6-14-30/h3-4,7-12,17-18H,2,5-6,13-16H2,1H3,(H,33,34)
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n/an/a 742n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261788
PNG
(N-(tert-Butylsulphonyl)-2-(9-ethyl-9H-carbazol-3-y...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)C(C)(C)C
Show InChI InChI=1S/C29H32N4O4S/c1-6-32-24-10-8-7-9-21(24)22-17-19(11-13-25(22)32)27-30-23-18-20(12-14-26(23)33(27)15-16-37-5)28(34)31-38(35,36)29(2,3)4/h7-14,17-18H,6,15-16H2,1-5H3,(H,31,34)
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n/an/a 768n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261820
PNG
(Ethyl-1-[2-(dimethylamino)ethyl]-2-(9-ethyl-9H-car...)
Show SMILES CCOC(=O)c1ccc2n(CCN(C)C)c(nc2c1)-c1ccc2n(CC)c3ccccc3c2c1
Show InChI InChI=1S/C28H30N4O2/c1-5-31-24-10-8-7-9-21(24)22-17-19(11-13-25(22)31)27-29-23-18-20(28(33)34-6-2)12-14-26(23)32(27)16-15-30(3)4/h7-14,17-18H,5-6,15-16H2,1-4H3
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n/an/a 872n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261880
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-N,1-dimethyl-1H-benzi...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)S(=O)(=O)NC
Show InChI InChI=1S/C23H22N4O2S/c1-4-27-20-8-6-5-7-17(20)18-13-15(9-11-21(18)27)23-25-19-14-16(30(28,29)24-2)10-12-22(19)26(23)3/h5-14,24H,4H2,1-3H3
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n/an/a 944n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261851
PNG
(2-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCCOC)C(C)(C)O
Show InChI InChI=1S/C28H31N3O2/c1-5-30-24-10-7-6-9-21(24)22-17-19(11-13-25(22)30)27-29-23-18-20(28(2,3)32)12-14-26(23)31(27)15-8-16-33-4/h6-7,9-14,17-18,32H,5,8,15-16H2,1-4H3
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n/an/a 989n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261845
PNG
(Methyl 1-ethyl-2-(9-ethyl-9H-carbazol-3-yl)-1H-ben...)
Show SMILES CCn1c(nc2cc(ccc12)C(=O)OC)-c1ccc2n(CC)c3ccccc3c2c1
Show InChI InChI=1S/C25H23N3O2/c1-4-27-21-9-7-6-8-18(21)19-14-16(10-12-22(19)27)24-26-20-15-17(25(29)30-3)11-13-23(20)28(24)5-2/h6-15H,4-5H2,1-3H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261860
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(C)cc2n1CC1CC1
Show InChI InChI=1S/C27H25N3O2/c1-3-29-23-7-5-4-6-19(23)21-13-18(10-11-24(21)29)26-28-22-14-20(27(31)32)16(2)12-25(22)30(26)15-17-8-9-17/h4-7,10-14,17H,3,8-9,15H2,1-2H3,(H,31,32)
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n/an/a 1.18E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261755
PNG
(4-Bromo-3-chloro-N1-(cyclopropylmethyl)benzene-1,2...)
Show SMILES Nc1c(Cl)c(Br)ccc1NCC1CC1
Show InChI InChI=1S/C10H12BrClN2/c11-7-3-4-8(10(13)9(7)12)14-5-6-1-2-6/h3-4,6,14H,1-2,5,13H2
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n/an/a 1.43E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261849
PNG
(Ethyl 2-(9-ethyl-9H-carbazol-3-yl)-1-(3-methoxypro...)
Show SMILES CCOC(=O)c1ccc2n(CCCOC)c(nc2c1)-c1ccc2n(CC)c3ccccc3c2c1
Show InChI InChI=1S/C28H29N3O3/c1-4-30-24-10-7-6-9-21(24)22-17-19(11-13-25(22)30)27-29-23-18-20(28(32)34-5-2)12-14-26(23)31(27)15-8-16-33-3/h6-7,9-14,17-18H,4-5,8,15-16H2,1-3H3
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n/an/a 1.71E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261834
PNG
(1-Allyl-2-(9-ethyl-9H-carbazol-3-yl)-N,N-dimethyl-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC=C)C(=O)N(C)C
Show InChI InChI=1S/C27H26N4O/c1-5-15-31-25-14-12-19(27(32)29(3)4)17-22(25)28-26(31)18-11-13-24-21(16-18)20-9-7-8-10-23(20)30(24)6-2/h5,7-14,16-17H,1,6,15H2,2-4H3
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n/an/a 1.86E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261837
PNG
(1-Allyl-2-(9-ethyl-9H-carbazol-3-yl)-N-methyl-1H-b...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC=C)C(=O)NC
Show InChI InChI=1S/C26H24N4O/c1-4-14-30-24-13-11-18(26(31)27-3)16-21(24)28-25(30)17-10-12-23-20(15-17)19-8-6-7-9-22(19)29(23)5-2/h4,6-13,15-16H,1,5,14H2,2-3H3,(H,27,31)
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n/an/a 2.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261819
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-[2-(morpholin-4-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN1CCOCC1)C(O)=O
Show InChI InChI=1S/C28H28N4O3/c1-2-31-24-6-4-3-5-21(24)22-17-19(7-9-25(22)31)27-29-23-18-20(28(33)34)8-10-26(23)32(27)12-11-30-13-15-35-16-14-30/h3-10,17-18H,2,11-16H2,1H3,(H,33,34)
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n/an/a 2.46E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261852
PNG
(1-(Cyclopropylmethyl)-2-(9-ethyl-9H-carbazol-3-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(OC)cc2n1CC1CC1
Show InChI InChI=1S/C27H25N3O3/c1-3-29-22-7-5-4-6-18(22)19-12-17(10-11-23(19)29)26-28-21-13-20(27(31)32)25(33-2)14-24(21)30(26)15-16-8-9-16/h4-7,10-14,16H,3,8-9,15H2,1-2H3,(H,31,32)
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n/an/a 2.83E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261839
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-N,1-dimethyl-1H-benzi...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)C(=O)NC
Show InChI InChI=1S/C24H22N4O/c1-4-28-20-8-6-5-7-17(20)18-13-15(9-11-21(18)28)23-26-19-14-16(24(29)25-2)10-12-22(19)27(23)3/h5-14H,4H2,1-3H3,(H,25,29)
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n/an/a 2.86E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261749
PNG
(Methyl 1-allyl-2-(9-ethyl-9H-carbazol-3-yl)-1H-ben...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC=C)C(=O)OC
Show InChI InChI=1S/C26H23N3O2/c1-4-14-29-24-13-11-18(26(30)31-3)16-21(24)27-25(29)17-10-12-23-20(15-17)19-8-6-7-9-22(19)28(23)5-2/h4,6-13,15-16H,1,5,14H2,2-3H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261853
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-6-methoxy-1-(2-methox...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(OC)cc2n1CCOC
Show InChI InChI=1S/C26H25N3O4/c1-4-28-21-8-6-5-7-17(21)18-13-16(9-10-22(18)28)25-27-20-14-19(26(30)31)24(33-3)15-23(20)29(25)11-12-32-2/h5-10,13-15H,4,11-12H2,1-3H3,(H,30,31)
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n/an/a 3.11E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261838
PNG
(1-Allyl-2-(9-ethyl-9H-carbazol-3-yl)-1H-benzimidaz...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC=C)C(N)=O
Show InChI InChI=1S/C25H22N4O/c1-3-13-29-23-12-9-16(24(26)30)15-20(23)27-25(29)17-10-11-22-19(14-17)18-7-5-6-8-21(18)28(22)4-2/h3,5-12,14-15H,1,4,13H2,2H3,(H2,26,30)
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n/an/a 3.64E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261786
PNG
(Ethyl 2-(9-ethyl-9H-carbazol-3-yl)-1-[2-(pyrrolidi...)
Show SMILES CCOC(=O)c1ccc2n(CCN3CCCC3)c(nc2c1)-c1ccc2n(CC)c3ccccc3c2c1
Show InChI InChI=1S/C30H32N4O2/c1-3-33-26-10-6-5-9-23(26)24-19-21(11-13-27(24)33)29-31-25-20-22(30(35)36-4-2)12-14-28(25)34(29)18-17-32-15-7-8-16-32/h5-6,9-14,19-20H,3-4,7-8,15-18H2,1-2H3
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n/an/a 3.78E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM261841
PNG
(Ethyl 2-(9-ethyl-9H-carbazol-3-yl)-1-isopropyl-1H-...)
Show SMILES CCOC(=O)c1ccc2n(C(C)C)c(nc2c1)-c1ccc2n(CC)c3ccccc3c2c1
Show InChI InChI=1S/C27H27N3O2/c1-5-29-23-10-8-7-9-20(23)21-15-18(11-13-24(21)29)26-28-22-16-19(27(31)32-6-2)12-14-25(22)30(26)17(3)4/h7-17H,5-6H2,1-4H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%