BindingDB logo
myBDB logout

Patent code US9708313

Compile Data Set for Download or QSAR
Found 142 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190939
PNG
(US9181249, 51 | US9708313, 51)
Show SMILES CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190986
PNG
(US9181249, 99 | US9708313, 99)
Show SMILES CO[C@@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190958
PNG
(US9181249, 71 | US9708313, 71)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-21-13-32(15(3)33)11-8-20(21)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190965
PNG
(US9181249, 78 | US9708313, 78)
Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H29ClFN5O/c1-14(2)26-22-23(28-20-13-29(3)9-8-19(20)27-22)30-10-6-15(7-11-30)21(31)17-12-16(24)4-5-18(17)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190937
PNG
(US9181249, 49 | US9708313, 49)
Show SMILES CN(C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)30-22(21(29-17)28-12-20(26)27)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190954
PNG
(US9181249, 67 | US9708313, 67)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190969
PNG
(US9181249, 156 | US9181249, 82 | US9708313, 156)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190966
PNG
(US9181249, 79 | US9708313, 79)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(C)=O
Show InChI InChI=1S/C24H29ClFN5O2/c1-14(2)27-23-24(29-21-13-31(15(3)32)11-8-20(21)28-23)30-9-6-16(7-10-30)22(33)18-12-17(25)4-5-19(18)26/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190999
PNG
(US9181249, 112 | US9708313, 112)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1S(C)(=O)=O)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-9-17-18(12-31(13)35(2,32)33)29-22(21(28-17)27-11-20(25)26)30-7-5-15(6-8-30)34-19-4-3-14(23)10-16(19)24/h3-4,10,13,15,20H,5-9,11-12H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.04E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190972
PNG
(US9181249, 85 | US9708313, 85)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C24H32F2N6O2/c1-15(2)27-22-23(29-19-9-12-32(14-20(19)28-22)24(33)30(3)4)31-10-7-17(8-11-31)34-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.04E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191005
PNG
(US9181249, 118 | US9708313, 118)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.14E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190978
PNG
(US9181249, 91 | US9708313, 91)
Show SMILES CC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)29-22(21(28-17)27-11-20(25)26)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.15E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190979
PNG
(US9181249, 92 | US9708313, 92)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC2CCC2)C(C)=O)c(F)c1
Show InChI InChI=1S/C25H32FN5O3/c1-16(32)31-13-10-21-22(15-31)29-25(24(28-21)27-17-4-3-5-17)30-11-8-18(9-12-30)34-23-7-6-19(33-2)14-20(23)26/h6-7,14,17-18H,3-5,8-13,15H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190963
PNG
(US9181249, 76 | US9708313, 76)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.34E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190973
PNG
(US9181249, 86 | US9708313, 86)
Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H29ClFN5O/c1-14(2)26-22-23(28-19-8-9-29(3)13-20(19)27-22)30-10-6-15(7-11-30)21(31)17-12-16(24)4-5-18(17)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190980
PNG
(US9181249, 93 | US9708313, 93)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC2CCC2)C(=O)N(C)C)c(F)c1
Show InChI InChI=1S/C26H35FN6O3/c1-31(2)26(34)33-14-11-21-22(16-33)30-25(24(29-21)28-17-5-4-6-17)32-12-9-18(10-13-32)36-23-8-7-19(35-3)15-20(23)27/h7-8,15,17-18H,4-6,9-14,16H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.38E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM261971
PNG
(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopr...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C24H32F2N6O2/c1-15(2)27-22-23(29-20-14-32(24(33)30(3)4)12-9-19(20)28-22)31-10-7-17(8-11-31)34-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.38E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190936
PNG
(US9181249, 141 | US9181249, 47 | US9708313, 141)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.38E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190904
PNG
(US9181249, 15 | US9708313, 15)
Show SMILES COCCNC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C25H34F2N6O3/c1-16(2)29-23-24(31-21-15-33(12-8-20(21)30-23)25(34)28-9-13-35-3)32-10-6-18(7-11-32)36-22-5-4-17(26)14-19(22)27/h4-5,14,16,18H,6-13,15H2,1-3H3,(H,28,34)(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.49E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190955
PNG
(US9181249, 68 | US9708313, 68)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@H](F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.52E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190960
PNG
(US9181249, 73 | US9708313, 73)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC(C)C)C(=O)N(C)C)c(F)c1
Show InChI InChI=1S/C25H35FN6O3/c1-16(2)27-23-24(29-21-15-32(25(33)30(3)4)13-10-20(21)28-23)31-11-8-17(9-12-31)35-22-7-6-18(34-5)14-19(22)26/h6-7,14,16-17H,8-13,15H2,1-5H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.66E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190897
PNG
(US9181249, 8 | US9708313, 8)
Show SMILES COC(C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C25H33F2N5O3/c1-15(2)28-23-24(30-20-9-12-32(14-21(20)29-23)25(33)16(3)34-4)31-10-7-18(8-11-31)35-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.68E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190957
PNG
(US9181249, 70 | US9708313, 70)
Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-20-13-30(3)9-8-19(20)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.71E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190899
PNG
(US9181249, 10 | US9708313, 10)
Show SMILES COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H31F2N5O3/c1-15(2)27-23-24(29-20-13-31(22(32)14-33-3)11-8-19(20)28-23)30-9-6-17(7-10-30)34-21-5-4-16(25)12-18(21)26/h4-5,12,15,17H,6-11,13-14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.73E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190894
PNG
(US9181249, 5 | US9708313, 5)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CCCO1
Show InChI InChI=1S/C26H33F2N5O3/c1-16(2)29-24-25(32-10-7-18(8-11-32)36-22-6-5-17(27)14-19(22)28)31-20-9-12-33(15-21(20)30-24)26(34)23-4-3-13-35-23/h5-6,14,16,18,23H,3-4,7-13,15H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.79E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190906
PNG
(US9181249, 17 | US9708313, 17)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)CC#N
Show InChI InChI=1S/C24H28F2N6O2/c1-15(2)28-23-24(30-20-14-32(22(33)5-9-27)12-8-19(20)29-23)31-10-6-17(7-11-31)34-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-8,10-12,14H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191001
PNG
(US9181249, 114 | US9708313, 114)
Show SMILES CO[C@H](C)C(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C
Show InChI InChI=1S/C25H31F4N5O3/c1-14-10-19-20(13-34(14)25(35)15(2)36-3)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)37-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,6-10,12-13H2,1-3H3,(H,30,31)/t14?,15-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.85E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190905
PNG
(US9181249, 16 | US9708313, 16)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CCCO1
Show InChI InChI=1S/C26H33F2N5O3/c1-16(2)29-24-25(32-10-7-18(8-11-32)36-22-6-5-17(27)14-19(22)28)31-21-15-33(12-9-20(21)30-24)26(34)23-4-3-13-35-23/h5-6,14,16,18,23H,3-4,7-13,15H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.95E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190964
PNG
(US9181249, 77 | US9708313, 77)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-20-9-12-34(14-21(20)30-23)25(35)32(3)4)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.97E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190981
PNG
(US9181249, 94 | US9708313, 94)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC2CCC2)C(C)=O)c(F)c1
Show InChI InChI=1S/C25H32FN5O3/c1-16(32)31-13-10-21-22(15-31)28-24(27-17-4-3-5-17)25(29-21)30-11-8-18(9-12-30)34-23-7-6-19(33-2)14-20(23)26/h6-7,14,17-18H,3-5,8-13,15H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.99E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191000
PNG
(US9181249, 113 | US9708313, 113)
Show SMILES CO[C@@H](C)C(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C
Show InChI InChI=1S/C25H31F4N5O3/c1-14-10-19-20(13-34(14)25(35)15(2)36-3)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)37-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,6-10,12-13H2,1-3H3,(H,30,31)/t14?,15-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.09E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190997
PNG
(US9181249, 110 | US9708313, 110)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-8-16-17(11-34(12)23(35)20(28)29)32-22(21(31-16)30-10-19(26)27)33-6-4-14(5-7-33)36-18-3-2-13(24)9-15(18)25/h2-3,9,12,14,19-20H,4-8,10-11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.21E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190998
PNG
(US9181249, 111 | US9708313, 111)
Show SMILES COCC(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C
Show InChI InChI=1S/C24H29F4N5O3/c1-14-9-18-19(12-33(14)22(34)13-35-2)31-24(23(30-18)29-11-21(27)28)32-7-5-16(6-8-32)36-20-4-3-15(25)10-17(20)26/h3-4,10,14,16,21H,5-9,11-13H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190996
PNG
(US9181249, 109 | US9708313, 109)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C22H27F4N5O/c1-13-9-17-18(12-30(13)2)29-22(21(28-17)27-11-20(25)26)31-7-5-15(6-8-31)32-19-4-3-14(23)10-16(19)24/h3-4,10,13,15,20H,5-9,11-12H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.32E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191006
PNG
(US9181249, 119 | US9708313, 119)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.36E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190959
PNG
(US9181249, 72 | US9708313, 72)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-21-14-34(25(35)32(3)4)12-9-20(21)30-23)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191002
PNG
(US9181249, 115 | US9708313, 115)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C1CC1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C25H29F4N5O2/c1-14-10-19-20(13-34(14)25(35)15-2-3-15)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)36-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,2-3,6-10,12-13H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.39E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190936
PNG
(US9181249, 141 | US9181249, 47 | US9708313, 141)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.46E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190994
PNG
(US9181249, 107 | US9708313, 107)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(C)=O)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H27F4N5O2/c1-13-9-18-19(12-32(13)14(2)33)30-23(22(29-18)28-11-21(26)27)31-7-5-16(6-8-31)34-20-4-3-15(24)10-17(20)25/h3-4,10,13,16,21H,5-9,11-12H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.49E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190967
PNG
(US9181249, 80 | US9708313, 80)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H32ClFN6O2/c1-15(2)28-23-24(30-21-14-33(25(35)31(3)4)12-9-20(21)29-23)32-10-7-16(8-11-32)22(34)18-13-17(26)5-6-19(18)27/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.49E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190956
PNG
(US9181249, 69 | US9708313, 69)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.65E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190946
PNG
(US9181249, 58 | US9708313, 58)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(C)CCc3nc2NC(C)C)c(F)c1
Show InChI InChI=1S/C23H32FN5O2/c1-15(2)25-22-23(27-20-14-28(3)10-9-19(20)26-22)29-11-7-16(8-12-29)31-21-6-5-17(30-4)13-18(21)24/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.66E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190983
PNG
(US9181249, 96 | US9708313, 96)
Show SMILES CN(C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)29-21(28-12-20(26)27)22(30-17)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.69E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191022
PNG
(US9181249, 134 | US9708313, 134)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O
Show InChI InChI=1S/C23H30F2N6O/c1-15(2)26-22-23(28-20-6-7-31(16(3)32)14-21(20)27-22)30-10-8-29(9-11-30)13-17-4-5-18(24)12-19(17)25/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.70E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191004
PNG
(US9181249, 117 | US9708313, 117)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.74E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191019
PNG
(US9181249, 131 | US9708313, 131)
Show SMILES CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C24H31F2N5O2/c1-4-22(32)31-12-9-19-20(14-31)28-23(27-15(2)3)24(29-19)30-10-7-17(8-11-30)33-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,4,7-12,14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.76E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191024
PNG
(US9181249, 136 | US9708313, 136)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H30F2N6O2S/c1-15(2)25-21-22(27-19-6-7-30(33(3,31)32)14-20(19)26-21)29-10-8-28(9-11-29)13-16-4-5-17(23)12-18(16)24/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.79E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191031
PNG
(US9181249, 143 | US9708313, 143)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(=O)C(C)C
Show InChI InChI=1S/C25H34F2N6O/c1-16(2)25(34)33-8-7-21-22(15-33)29-23(28-17(3)4)24(30-21)32-11-9-31(10-12-32)14-18-5-6-19(26)13-20(18)27/h5-6,13,16-17H,7-12,14-15H2,1-4H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.90E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190893
PNG
(US9181249, 4 | US9708313, 4)
Show SMILES COCCNC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C25H34F2N6O3/c1-16(2)29-23-24(31-20-8-12-33(15-21(20)30-23)25(34)28-9-13-35-3)32-10-6-18(7-11-32)36-22-5-4-17(26)14-19(22)27/h4-5,14,16,18H,6-13,15H2,1-3H3,(H,28,34)(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.98E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190962
PNG
(US9181249, 75 | US9708313, 75)
Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-19-8-9-30(3)13-20(19)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.03E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191025
PNG
(US9181249, 137 | US9708313, 137)
Show SMILES CCC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1
Show InChI InChI=1S/C24H32F2N6O/c1-4-22(33)32-8-7-20-21(15-32)28-23(27-16(2)3)24(29-20)31-11-9-30(10-12-31)14-17-5-6-18(25)13-19(17)26/h5-6,13,16H,4,7-12,14-15H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.09E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190995
PNG
(US9181249, 108 | US9708313, 108)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)N(C)C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H30F4N6O2/c1-14-10-18-19(13-34(14)24(35)32(2)3)31-23(22(30-18)29-12-21(27)28)33-8-6-16(7-9-33)36-20-5-4-15(25)11-17(20)26/h4-5,11,14,16,21H,6-10,12-13H2,1-3H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.14E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190982
PNG
(US9181249, 95 | US9708313, 95)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC2CCC2)C(=O)N(C)C)c(F)c1
Show InChI InChI=1S/C26H35FN6O3/c1-31(2)26(34)33-14-11-21-22(16-33)29-24(28-17-5-4-6-17)25(30-21)32-12-9-18(10-13-32)36-23-8-7-19(35-3)15-20(23)27/h7-8,15,17-18H,4-6,9-14,16H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.25E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190975
PNG
(US9181249, 88 | US9708313, 88)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H32ClFN6O2/c1-15(2)28-23-24(30-20-9-12-33(14-21(20)29-23)25(35)31(3)4)32-10-7-16(8-11-32)22(34)18-13-17(26)5-6-19(18)27/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.27E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190936
PNG
(US9181249, 141 | US9181249, 47 | US9708313, 141)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190935
PNG
(US9181249, 46 | US9708313, 46)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(=O)N(C)C)c(F)c1
Show InChI InChI=1S/C25H35FN6O3/c1-16(2)27-23-24(29-20-10-13-32(15-21(20)28-23)25(33)30(3)4)31-11-8-17(9-12-31)35-22-7-6-18(34-5)14-19(22)26/h6-7,14,16-17H,8-13,15H2,1-5H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191039
PNG
(US9181249, 151 | US9708313, 151)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CC(F)(F)C3)nc2C1
Show InChI InChI=1S/C24H27F4N5O2/c1-14(34)33-9-6-19-20(13-33)30-22(29-16-11-24(27,28)12-16)23(31-19)32-7-4-17(5-8-32)35-21-3-2-15(25)10-18(21)26/h2-3,10,16-17H,4-9,11-13H2,1H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.59E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM261953
PNG
((R)-1-(2-(4-((2,4-difluorophenyl)fluoromethyl)pipe...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.78E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190907
PNG
(US9181249, 18 | US9708313, 18)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)c1ccno1
Show InChI InChI=1S/C25H28F2N6O3/c1-15(2)29-23-24(32-10-6-17(7-11-32)35-21-4-3-16(26)13-18(21)27)31-19-8-12-33(14-20(19)30-23)25(34)22-5-9-28-36-22/h3-5,9,13,15,17H,6-8,10-12,14H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.87E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191038
PNG
(US9181249, 150 | US9708313, 150)
Show SMILES CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3CCOC3)nc2C1
Show InChI InChI=1S/C25H31F2N5O3/c1-2-23(33)32-11-7-20-21(14-32)29-24(28-17-8-12-34-15-17)25(30-20)31-9-5-18(6-10-31)35-22-4-3-16(26)13-19(22)27/h3-4,13,17-18H,2,5-12,14-15H2,1H3,(H,28,29)/t17-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.92E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191011
PNG
(US9181249, 124 | US9708313, 124)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C=O
Show InChI InChI=1S/C22H27F2N5O2/c1-14(2)25-21-22(27-19-12-28(13-30)8-7-18(19)26-21)29-9-5-16(6-10-29)31-20-4-3-15(23)11-17(20)24/h3-4,11,13-14,16H,5-10,12H2,1-2H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.32E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191023
PNG
(US9181249, 135 | US9708313, 135)
Show SMILES CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC3CCC3)nc2C1
Show InChI InChI=1S/C24H30F2N6O/c1-16(33)32-8-7-21-22(15-32)28-23(27-19-3-2-4-19)24(29-21)31-11-9-30(10-12-31)14-17-5-6-18(25)13-20(17)26/h5-6,13,19H,2-4,7-12,14-15H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191040
PNG
(US9181249, 152 | US9708313, 152)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1
Show InChI InChI=1S/C23H29F2N5O3S/c1-34(31,32)30-12-9-19-20(14-30)27-22(26-16-3-2-4-16)23(28-19)29-10-7-17(8-11-29)33-21-6-5-15(24)13-18(21)25/h5-6,13,16-17H,2-4,7-12,14H2,1H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.93E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190947
PNG
(US9181249, 59 | US9708313, 59)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)28-21(27-11-20(25)26)22(29-17)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.97E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190922
PNG
(US9181249, 33 | US9708313, 33)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-21(27-12-19(25)26)22(29-20)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191015
PNG
(US9181249, 128 | US9708313, 128)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1
Show InChI InChI=1S/C24H29F2N5O2/c1-15(32)31-12-9-20-21(14-31)28-23(27-17-3-2-4-17)24(29-20)30-10-7-18(8-11-30)33-22-6-5-16(25)13-19(22)26/h5-6,13,17-18H,2-4,7-12,14H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190895
PNG
(US9181249, 6 | US9708313, 6)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)CC#N
Show InChI InChI=1S/C24H28F2N6O2/c1-15(2)28-23-24(30-19-8-12-32(14-20(19)29-23)22(33)5-9-27)31-10-6-17(7-11-31)34-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-8,10-12,14H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.52E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190987
PNG
(US9181249, 100 | US9708313, 100)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)27-20(26-11-19(24)25)21(28-16)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.72E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191037
PNG
(US9181249, 149 | US9708313, 149)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3CCOC3)nc2C1
Show InChI InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.87E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191043
PNG
(US9181249, 155 | US9708313, 155)
Show SMILES CCC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1
Show InChI InChI=1S/C25H32F2N6O2/c1-2-23(34)33-7-5-21-22(15-33)29-24(28-19-6-12-35-16-19)25(30-21)32-10-8-31(9-11-32)14-17-3-4-18(26)13-20(17)27/h3-4,13,19H,2,5-12,14-16H2,1H3,(H,28,29)/t19-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.91E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190942
PNG
(US9181249, 54 | US9708313, 54)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(27-19-9-12-30(34(4,31)32)15(3)21(19)28-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.93E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190968
PNG
(US9181249, 81 | US9708313, 81)
Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C22H29F2N5O/c1-14(2)25-21-22(27-19-13-28(3)9-8-18(19)26-21)29-10-6-16(7-11-29)30-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.95E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191032
PNG
(US9181249, 144 | US9708313, 144)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@@H]3C[C@H](O)C3)nc2C1
Show InChI InChI=1S/C24H29F2N5O3/c1-14(32)31-9-6-20-21(13-31)28-23(27-16-11-17(33)12-16)24(29-20)30-7-4-18(5-8-30)34-22-3-2-15(25)10-19(22)26/h2-3,10,16-18,33H,4-9,11-13H2,1H3,(H,27,28)/t16-,17+
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.15E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190892
PNG
(US9181249, 3 | US9708313, 3)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-18-8-11-29(33(3,30)31)13-19(18)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.18E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191017
PNG
(US9181249, 129 | US9708313, 129)
Show SMILES CC[C@H](C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-4-15(2)27-23-24(29-20-9-12-31(16(3)32)14-21(20)28-23)30-10-7-18(8-11-30)33-22-6-5-17(25)13-19(22)26/h5-6,13,15,18H,4,7-12,14H2,1-3H3,(H,27,28)/t15-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM261935
PNG
(1-(3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)...)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3C(C)N(CCc3nc2NC(C)C)C(C)=O)c(F)c1
Show InChI InChI=1S/C25H34FN5O3/c1-15(2)27-24-25(29-23-16(3)31(17(4)32)13-10-21(23)28-24)30-11-8-18(9-12-30)34-22-7-6-19(33-5)14-20(22)26/h6-7,14-16,18H,8-13H2,1-5H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.25E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM261909
PNG
((2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isop...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H34F2N6O3/c1-17(2)29-24-25(32-8-5-19(6-9-32)37-23-4-3-18(27)15-20(23)28)31-21-7-10-34(16-22(21)30-24)26(35)33-11-13-36-14-12-33/h3-4,15,17,19H,5-14,16H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.26E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191041
PNG
(US9181249, 153 | US9708313, 153)
Show SMILES CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2C1
Show InChI InChI=1S/C24H30F2N6O2/c1-16(33)32-6-4-21-22(14-32)28-23(27-19-5-11-34-15-19)24(29-21)31-9-7-30(8-10-31)13-17-2-3-18(25)12-20(17)26/h2-3,12,19H,4-11,13-15H2,1H3,(H,27,28)/t19-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.32E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190990
PNG
(US9181249, 103 | US9708313, 103)
Show SMILES CO[C@H](C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)30-22(29-12-21(27)28)23(31-18)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.40E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190923
PNG
(US9181249, 34 | US9708313, 34)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-23(29-12-20(27)28)24(31-22)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190950
PNG
(US9181249, 62 | US9708313, 62)
Show SMILES CC(C)Nc1nc2CCN(CCF)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-20-14-30(12-8-24)9-7-19(20)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.92E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190891
PNG
(US9181249, 2 | US9708313, 2)
Show SMILES COCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C24H31F2N5O3/c1-15(2)27-23-24(29-19-8-11-31(13-20(19)28-23)22(32)14-33-3)30-9-6-17(7-10-30)34-21-5-4-16(25)12-18(21)26/h4-5,12,15,17H,6-11,13-14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.15E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190940
PNG
(US9181249, 52 | US9708313, 52)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(28-20-9-12-31(16(4)32)15(3)22(20)29-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.32E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190969
PNG
(US9181249, 156 | US9181249, 82 | US9708313, 156)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190934
PNG
(US9181249, 45 | US9708313, 45)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(C)=O)c(F)c1
Show InChI InChI=1S/C24H32FN5O3/c1-15(2)26-23-24(28-20-9-12-30(16(3)31)14-21(20)27-23)29-10-7-17(8-11-29)33-22-6-5-18(32-4)13-19(22)25/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.41E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191021
PNG
(US9181249, 133 | US9708313, 133)
Show SMILES CC(C)Nc1nc2CN(CCF)CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-19-7-9-30(12-8-24)14-20(19)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.48E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190921
PNG
(US9181249, 32 | US9708313, 32)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-22(28-12-20(26)27)23(30-21)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.60E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191036
PNG
(US9181249, 148 | US9708313, 148)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3C[C@H](O)C3)nc2C1
Show InChI InChI=1S/C24H29F2N5O3/c1-14(32)31-9-6-20-21(13-31)28-23(27-16-11-17(33)12-16)24(29-20)30-7-4-18(5-8-30)34-22-3-2-15(25)10-19(22)26/h2-3,10,16-18,33H,4-9,11-13H2,1H3,(H,27,28)/t16-,17-
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190911
PNG
(US9181249, 22 | US9708313, 22)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)[C@@H]1CCCN1C
Show InChI InChI=1S/C27H36F2N6O2/c1-17(2)30-25-26(34-12-8-19(9-13-34)37-24-7-6-18(28)15-20(24)29)32-21-10-14-35(16-22(21)31-25)27(36)23-5-4-11-33(23)3/h6-7,15,17,19,23H,4-5,8-14,16H2,1-3H3,(H,30,31)/t23-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.81E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190988
PNG
(US9181249, 101 | US9708313, 101)
Show SMILES FC(F)CNc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C22H23F6N5O2/c23-12-1-2-17(14(24)9-12)35-13-3-6-32(7-4-13)21-20(29-10-18(25)26)30-16-11-33(22(34)19(27)28)8-5-15(16)31-21/h1-2,9,13,18-19H,3-8,10-11H2,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.88E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190938
PNG
(US9181249, 50 | US9708313, 50)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H27F4N5O3/c1-34-13-21(33)32-9-6-17-18(12-32)30-23(22(29-17)28-11-20(26)27)31-7-4-15(5-8-31)35-19-3-2-14(24)10-16(19)25/h2-3,10,15,20H,4-9,11-13H2,1H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.95E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190927
PNG
(US9181249, 38 | US9708313, 38)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-24(23(32-22)30-13-21(28)29)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,32)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190896
PNG
(US9181249, 7 | US9708313, 7)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(cc1F)C#N)C(C)=O
Show InChI InChI=1S/C24H29FN6O2/c1-15(2)27-23-24(29-20-8-11-31(16(3)32)14-21(20)28-23)30-9-6-18(7-10-30)33-22-5-4-17(13-26)12-19(22)25/h4-5,12,15,18H,6-11,14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.66E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190919
PNG
(US9181249, 30 | US9708313, 30)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-22(21(29-20)27-12-19(25)26)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.70E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190924
PNG
(US9181249, 35 | US9708313, 35)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(29-22-15(3)31(16(4)32)12-9-20(22)28-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190971
PNG
(US9181249, 84 | US9708313, 84)
Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C22H29F2N5O/c1-14(2)25-21-22(27-18-8-9-28(3)13-19(18)26-21)29-10-6-16(7-11-29)30-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.01E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190926
PNG
(US9181249, 37 | US9708313, 37)
Show SMILES COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C25H33F2N5O3/c1-15(2)28-24-25(30-23-16(3)32(22(33)14-34-4)12-9-20(23)29-24)31-10-7-18(8-11-31)35-21-6-5-17(26)13-19(21)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190945
PNG
(US9181249, 57 | US9708313, 57)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C24H30F4N6O2/c1-14-21-18(8-11-34(14)24(35)32(2)3)30-22(29-13-20(27)28)23(31-21)33-9-6-16(7-10-33)36-19-5-4-15(25)12-17(19)26/h4-5,12,14,16,20H,6-11,13H2,1-3H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.35E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190941
PNG
(US9181249, 53 | US9708313, 53)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(30-18-8-11-33(24(34)21(27)28)14(3)20(18)31-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190900
PNG
(US9181249, 11 | US9708313, 11)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-19-13-29(33(3,30)31)11-8-18(19)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.56E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191042
PNG
(US9181249, 154 | US9708313, 154)
Show SMILES CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1
Show InChI InChI=1S/C24H30F2N6O2/c1-16(33)32-6-4-21-22(14-32)28-23(27-19-5-11-34-15-19)24(29-21)31-9-7-30(8-10-31)13-17-2-3-18(25)12-20(17)26/h2-3,12,19H,4-11,13-15H2,1H3,(H,27,28)/t19-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.78E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190925
PNG
(US9181249, 36 | US9708313, 36)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(28-21-15(3)30(34(4,31)32)12-9-19(21)27-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190908
PNG
(US9181249, 19 | US9708313, 19)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(cc1F)C#N)C(C)=O
Show InChI InChI=1S/C24H29FN6O2/c1-15(2)27-23-24(29-21-14-31(16(3)32)11-8-20(21)28-23)30-9-6-18(7-10-30)33-22-5-4-17(13-26)12-19(22)25/h4-5,12,15,18H,6-11,14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.05E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191013
PNG
(US9181249, 126 | US9708313, 126)
Show SMILES C[C@@H](CCO)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O3/c1-15(8-12-32)27-23-24(29-20-7-11-31(16(2)33)14-21(20)28-23)30-9-5-18(6-10-30)34-22-4-3-17(25)13-19(22)26/h3-4,13,15,18,32H,5-12,14H2,1-2H3,(H,27,28)/t15-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.07E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190943
PNG
(US9181249, 55 | US9708313, 55)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(29-20-10-13-33(25(34)31(4)5)16(3)22(20)30-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190985
PNG
(US9181249, 98 | US9708313, 98)
Show SMILES FC(F)CNc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C22H23F6N5O2/c23-12-1-2-17(14(24)9-12)35-13-3-6-32(7-4-13)21-20(29-10-18(25)26)30-15-5-8-33(11-16(15)31-21)22(34)19(27)28/h1-2,9,13,18-19H,3-8,10-11H2,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.11E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190989
PNG
(US9181249, 102 | US9708313, 102)
Show SMILES CO[C@@H](C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)30-22(29-12-21(27)28)23(31-18)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.11E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191030
PNG
(US9181249, 142 | US9708313, 142)
Show SMILES CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20+
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.14E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190932
PNG
(US9181249, 43 | US9708313, 43)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(31-20-14(3)33(24(34)21(27)28)11-8-18(20)30-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.16E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190909
PNG
(US9181249, 20 | US9708313, 20)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(cc1F)C#N)C(=O)C1CC1
Show InChI InChI=1S/C26H31FN6O2/c1-16(2)29-24-25(31-22-15-33(12-9-21(22)30-24)26(34)18-4-5-18)32-10-7-19(8-11-32)35-23-6-3-17(14-28)13-20(23)27/h3,6,13,16,18-19H,4-5,7-12,15H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.22E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191028
PNG
(US9181249, 140 | US9708313, 140)
Show SMILES CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3C[C@H](O)C3)nc2C1
Show InChI InChI=1S/C24H30F2N6O2/c1-15(33)32-5-4-21-22(14-32)28-23(27-18-11-19(34)12-18)24(29-21)31-8-6-30(7-9-31)13-16-2-3-17(25)10-20(16)26/h2-3,10,18-19,34H,4-9,11-14H2,1H3,(H,27,28)/t18-,19+
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.22E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190928
PNG
(US9181249, 39 | US9708313, 39)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-23(30-13-21(28)29)24(32-22)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.26E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190913
PNG
(US9181249, 24 | US9708313, 24)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H27F4N5O2/c1-13(2)28-21-22(30-17-7-10-32(12-18(17)29-21)23(33)20(26)27)31-8-5-15(6-9-31)34-19-4-3-14(24)11-16(19)25/h3-4,11,13,15,20H,5-10,12H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.29E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191020
PNG
(US9181249, 132 | US9708313, 132)
Show SMILES COC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-18-8-11-30(23(31)32-3)13-19(18)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.30E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190949
PNG
(US9181249, 61 | US9708313, 61)
Show SMILES COC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-19-13-30(23(31)32-3)11-8-18(19)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.32E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190961
PNG
(US9181249, 74 | US9708313, 74)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(C)Cc3nc2NC(C)C)c(F)c1
Show InChI InChI=1S/C23H32FN5O2/c1-15(2)25-22-23(27-19-9-10-28(3)14-20(19)26-22)29-11-7-16(8-12-29)31-21-6-5-17(30-4)13-18(21)24/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.40E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190953
PNG
(US9181249, 66 | US9708313, 66)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(C)CCc3nc2NC2CC2)c(F)c1
Show InChI InChI=1S/C23H30FN5O2/c1-28-10-9-19-20(14-28)27-23(22(26-19)25-15-3-4-15)29-11-7-16(8-12-29)31-21-6-5-17(30-2)13-18(21)24/h5-6,13,15-16H,3-4,7-12,14H2,1-2H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.45E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190910
PNG
(US9181249, 21 | US9708313, 21)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H33F2N5O3S/c1-15(2)27-23-24(29-20-9-12-31(14-21(20)28-23)35(32,33)16(3)4)30-10-7-18(8-11-30)34-22-6-5-17(25)13-19(22)26/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.49E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190984
PNG
(US9181249, 97 | US9708313, 97)
Show SMILES CS(=O)(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)28-21(20(27-16)26-11-19(24)25)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.63E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190918
PNG
(US9181249, 29 | US9708313, 29)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-23(22(30-21)28-12-20(26)27)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.78E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190944
PNG
(US9181249, 56 | US9708313, 56)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(30-22-16(3)33(25(34)31(4)5)13-10-20(22)29-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.79E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191033
PNG
(US9181249, 145 | US9708313, 145)
Show SMILES CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3C[C@H](F)C3)nc2C1
Show InChI InChI=1S/C24H29F3N6O/c1-15(34)33-5-4-21-22(14-33)29-23(28-19-10-18(26)11-19)24(30-21)32-8-6-31(7-9-32)13-16-2-3-17(25)12-20(16)27/h2-3,12,18-19H,4-11,13-14H2,1H3,(H,28,29)/t18-,19-
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.86E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191010
PNG
(US9181249, 123 | US9708313, 123)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)S(=O)(=O)c1ccc(F)cc1)C(C)=O
Show InChI InChI=1S/C23H30FN5O3S/c1-15(2)25-22-23(27-21-14-29(16(3)30)13-10-20(21)26-22)28-11-8-19(9-12-28)33(31,32)18-6-4-17(24)5-7-18/h4-7,15,19H,8-14H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.88E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190931
PNG
(US9181249, 42 | US9708313, 42)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.93E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191003
PNG
(US9181249, 116 | US9708313, 116)
Show SMILES CC(C)Nc1nc2CCN(CC(F)F)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H29F4N5O/c1-14(2)28-22-23(30-19-12-31(13-21(26)27)8-7-18(19)29-22)32-9-5-16(6-10-32)33-20-4-3-15(24)11-17(20)25/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191012
PNG
(US9181249, 125 | US9708313, 125)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)C1CCN(CC1)c1nc2CN(CCc2nc1NC(C)C)C(C)=O
Show InChI InChI=1S/C24H32FN5O4S/c1-15(2)26-23-24(28-21-14-30(16(3)31)12-9-20(21)27-23)29-10-7-18(8-11-29)35(32,33)22-6-5-17(34-4)13-19(22)25/h5-6,13,15,18H,7-12,14H2,1-4H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190920
PNG
(US9181249, 31 | US9708313, 31)
Show SMILES COCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1C
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-24(23(31-22)29-12-20(27)28)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.08E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190898
PNG
(US9181249, 9 | US9708313, 9)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C25H31F2N5O2/c1-15(2)28-23-24(30-21-14-32(12-9-20(21)29-23)25(33)16-3-4-16)31-10-7-18(8-11-31)34-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,3-4,7-12,14H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.11E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190930
PNG
(US9181249, 41 | US9708313, 41)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-22(21(32-19)30-11-18(26)27)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,32)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.12E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191027
PNG
(US9181249, 139 | US9708313, 139)
Show SMILES CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O
Show InChI InChI=1S/C26H32F2N6O3/c1-16(35)34-6-5-23-24(15-34)30-25(29-20-12-21(13-20)37-17(2)36)26(31-23)33-9-7-32(8-10-33)14-18-3-4-19(27)11-22(18)28/h3-4,11,20-21H,5-10,12-15H2,1-2H3,(H,29,30)/t20-,21+
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.20E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191009
PNG
(US9181249, 122 | US9708313, 122)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)S(=O)(=O)c1ccccc1F)C(C)=O
Show InChI InChI=1S/C23H30FN5O3S/c1-15(2)25-22-23(27-20-14-29(16(3)30)13-10-19(20)26-22)28-11-8-17(9-12-28)33(31,32)21-7-5-4-6-18(21)24/h4-7,15,17H,8-14H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.47E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191007
PNG
(US9181249, 120 | US9708313, 120)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)S(=O)(=O)c1cccc(F)c1)C(C)=O
Show InChI InChI=1S/C23H30FN5O3S/c1-15(2)25-22-23(27-21-14-29(16(3)30)12-9-20(21)26-22)28-10-7-18(8-11-28)33(31,32)19-6-4-5-17(24)13-19/h4-6,13,15,18H,7-12,14H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.50E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190929
PNG
(US9181249, 40 | US9708313, 40)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C26H33F2N5O2/c1-15(2)29-24-25(31-23-16(3)33(13-10-21(23)30-24)26(34)17-4-5-17)32-11-8-19(9-12-32)35-22-7-6-18(27)14-20(22)28/h6-7,14-17,19H,4-5,8-13H2,1-3H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.59E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191018
PNG
(US9181249, 130 | US9708313, 130)
Show SMILES CC[C@@H](C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-4-15(2)27-23-24(29-20-9-12-31(16(3)32)14-21(20)28-23)30-10-7-18(8-11-30)33-22-6-5-17(25)13-19(22)26/h5-6,13,15,18H,4,7-12,14H2,1-3H3,(H,27,28)/t15-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.19E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190890
PNG
(US9181249, 1 | US9708313, 1)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C25H31F2N5O2/c1-15(2)28-23-24(30-20-9-12-32(14-21(20)29-23)25(33)16-3-4-16)31-10-7-18(8-11-31)34-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,3-4,7-12,14H2,1-2H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.40E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191008
PNG
(US9181249, 121 | US9708313, 121)
Show SMILES COc1cccc(c1)S(=O)(=O)C1CCN(CC1)c1nc2CN(CCc2nc1NC(C)C)C(C)=O
Show InChI InChI=1S/C24H33N5O4S/c1-16(2)25-23-24(27-22-15-29(17(3)30)13-10-21(22)26-23)28-11-8-19(9-12-28)34(31,32)20-7-5-6-18(14-20)33-4/h5-7,14,16,19H,8-13,15H2,1-4H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.42E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191034
PNG
(US9181249, 146 | US9708313, 146)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(cc2F)C#N)CC1)C(C)=O
Show InChI InChI=1S/C24H30FN7O/c1-16(2)27-23-24(29-21-6-7-32(17(3)33)15-22(21)28-23)31-10-8-30(9-11-31)14-19-5-4-18(13-26)12-20(19)25/h4-5,12,16H,6-11,14-15H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.63E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190912
PNG
(US9181249, 23 | US9708313, 23)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N1CCCC1
Show InChI InChI=1S/C26H34F2N6O2/c1-17(2)29-24-25(32-12-7-19(8-13-32)36-23-6-5-18(27)15-20(23)28)31-21-9-14-34(16-22(21)30-24)26(35)33-10-3-4-11-33/h5-6,15,17,19H,3-4,7-14,16H2,1-2H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.91E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191035
PNG
(US9181249, 147 | US9708313, 147)
Show SMILES CC(=O)O[C@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20-
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.04E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191014
PNG
(US9181249, 127 | US9708313, 127)
Show SMILES C[C@H](CCO)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O3/c1-15(8-12-32)27-23-24(29-20-7-11-31(16(2)33)14-21(20)28-23)30-9-5-18(6-10-30)34-22-4-3-17(25)13-19(22)26/h3-4,13,15,18,32H,5-12,14H2,1-2H3,(H,27,28)/t15-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM190948
PNG
(US9181249, 60 | US9708313, 60)
Show SMILES CN1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O/c1-29-7-6-16-17(12-29)27-20(26-11-19(24)25)21(28-16)30-8-4-14(5-9-30)31-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
G-protein coupled receptor 6 (GPR6)


(Homo sapiens (Human))
BDBM191026
PNG
(US9181249, 138 | US9708313, 138)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(CC1)C(=O)OC(C)(C)C)C(C)=O
Show InChI InChI=1S/C21H34N6O3/c1-14(2)22-18-19(24-16-7-8-27(15(3)28)13-17(16)23-18)25-9-11-26(12-10-25)20(29)30-21(4,5)6/h14H,7-13H2,1-6H3,(H,22,23)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%