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Patent code US9708318

Compile Data Set for Download or QSAR

Found 856 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261979
PNG
(3-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cc(F)cc(c2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H21F3N6O3/c1-14-19(13-34(2)33-14)20-8-21-16(11-32-20)12-35(26-24(29)22(38-3)9-23(39-4)25(26)30)27(37)36(21)18-6-15(10-31)5-17(28)7-18/h5-9,11,13H,12H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261986
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cnccn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H23F2N7O3/c1-14-17(13-32(2)31-14)18-7-19-15(9-30-18)11-34(25(35)33(19)12-16-10-28-5-6-29-16)24-22(26)20(36-3)8-21(37-4)23(24)27/h5-10,13H,11-12H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM261989
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cccnn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H23F2N7O3/c1-14-17(13-32(2)31-14)18-8-19-15(10-28-18)11-34(25(35)33(19)12-16-6-5-7-29-30-16)24-22(26)20(36-3)9-21(37-4)23(24)27/h5-10,13H,11-12H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM261992
PNG
(1-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)C2(CC2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H22F2N6O3/c1-13-15(11-30(2)29-13)16-7-17-14(9-28-16)10-31(23(33)32(17)24(12-27)5-6-24)22-20(25)18(34-3)8-19(35-4)21(22)26/h7-9,11H,5-6,10H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261994
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(on3)C(C)C)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H28F2N6O4/c1-14(2)21-7-17(32-39-21)12-34-20-8-19(18-13-33(4)31-15(18)3)30-10-16(20)11-35(27(34)36)26-24(28)22(37-5)9-23(38-6)25(26)29/h7-10,13-14H,11-12H2,1-6H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM262002
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cn(C)nc3C)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H27F2N7O3/c1-14-17(10-32(3)30-14)12-34-20-7-19(18-13-33(4)31-15(18)2)29-9-16(20)11-35(26(34)36)25-23(27)21(37-5)8-22(38-6)24(25)28/h7-10,13H,11-12H2,1-6H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262010
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cccc(c1)N1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H25F2N5O4/c1-15-19(14-32(2)31-15)20-10-21-16(12-30-20)13-33(26-24(28)22(37-4)11-23(38-5)25(26)29)27(35)34(21)17-7-6-8-18(9-17)36-3/h6-12,14H,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262028
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(CCCN3CCOCC3)nc2C)c1F
Show InChI InChI=1S/C29H33F2N5O4/c1-18-20(17-35(33-18)8-4-7-34-9-11-40-12-10-34)22-13-21-19(15-32-22)16-36(28(37)29(21)5-6-29)27-25(30)23(38-2)14-24(39-3)26(27)31/h13-15,17H,4-12,16H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262029
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(1- (...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CCN(C2)S(C)(=O)=O)c1F
Show InChI InChI=1S/C26H27F2N5O5S/c1-37-20-9-21(38-2)23(28)24(22(20)27)32-12-15-10-29-19(8-18(15)26(5-6-26)25(32)34)16-11-30-33(13-16)17-4-7-31(14-17)39(3,35)36/h8-11,13,17H,4-7,12,14H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262035
PNG
(2-(4-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(CC#N)nc2C)c1F
Show InChI InChI=1S/C24H21F2N5O3/c1-13-15(12-30(29-13)7-6-27)17-8-16-14(10-28-17)11-31(23(32)24(16)4-5-24)22-20(25)18(33-2)9-19(34-3)21(22)26/h8-10,12H,4-5,7,11H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM262049
PNG
(6'-(1-((1-acetylazetidin-3- yl)methyl)-1H-pyrazol-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(CC3CN(C3)C(C)=O)c2)c1F
Show InChI InChI=1S/C27H27F2N5O4/c1-15(35)32-10-16(11-32)12-33-13-18(9-31-33)20-6-19-17(8-30-20)14-34(26(36)27(19)4-5-27)25-23(28)21(37-2)7-22(38-3)24(25)29/h6-9,13,16H,4-5,10-12,14H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM262050
PNG
(US9708318, 168)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(CC)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C23H25F2N5O3/c1-6-28-12-15(13(3)27-28)16-8-17-14(10-26-16)11-30(23(31)29(17)7-2)22-20(24)18(32-4)9-19(33-5)21(22)25/h8-10,12H,6-7,11H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM262057
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H25F2N5O4/c1-5-28-24(33)16-8-7-14(11-29-16)17-9-18-15(12-30-17)13-32(25(34)31(18)6-2)23-21(26)19(35-3)10-20(36-4)22(23)27/h7-12H,5-6,13H2,1-4H3,(H,28,33)
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US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262064
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-7-(6-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)N1CCOCC1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-4-32-19-11-18(16-5-6-22(30-13-16)31-7-9-37-10-8-31)29-14-17(19)15-33(26(32)34)25-23(27)20(35-2)12-21(36-3)24(25)28/h5-6,11-14H,4,7-10,15H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM262066
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(N)=O)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C23H21F2N5O4/c1-4-29-16-7-15(12-5-6-14(22(26)31)27-9-12)28-10-13(16)11-30(23(29)32)21-19(24)17(33-2)8-18(34-3)20(21)25/h5-10H,4,11H2,1-3H3,(H2,26,31)
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262030
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(2-(1...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(CCC3CCN(CC3)S(C)(=O)=O)c2)c1F
Show InChI InChI=1S/C29H33F2N5O5S/c1-40-23-13-24(41-2)26(31)27(25(23)30)36-17-19-14-32-22(12-21(19)29(7-8-29)28(36)37)20-15-33-34(16-20)9-4-18-5-10-35(11-6-18)42(3,38)39/h12-16,18H,4-11,17H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262031
PNG
(1-(4-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2C)C2(CCC2)C#N)c1F
Show InChI InChI=1S/C27H25F2N5O3/c1-15-17(12-32-34(15)26(14-30)5-4-6-26)19-9-18-16(11-31-19)13-33(25(35)27(18)7-8-27)24-22(28)20(36-2)10-21(37-3)23(24)29/h9-12H,4-8,13H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM262045
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(nc2C)C2CCN(C)C2)c1F
Show InChI InChI=1S/C27H29F2N5O3/c1-15-18(14-34(31-15)17-5-8-32(2)13-17)20-9-19-16(11-30-20)12-33(26(35)27(19)6-7-27)25-23(28)21(36-3)10-22(37-4)24(25)29/h9-11,14,17H,5-8,12-13H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM262052
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H23F2N5O3/c1-6-28-16-7-15(14-11-27(3)26-12(14)2)25-9-13(16)10-29(22(28)30)21-19(23)17(31-4)8-18(32-5)20(21)24/h7-9,11H,6,10H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262052
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H23F2N5O3/c1-6-28-16-7-15(14-11-27(3)26-12(14)2)25-9-13(16)10-29(22(28)30)21-19(23)17(31-4)8-18(32-5)20(21)24/h7-9,11H,6,10H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262053
PNG
(5-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2[nH]ncc2C#N)c1F
Show InChI InChI=1S/C22H17F2N5O3/c1-31-15-6-16(32-2)18(24)20(17(15)23)29-10-12-8-26-14(19-11(7-25)9-27-28-19)5-13(12)22(3-4-22)21(29)30/h5-6,8-9H,3-4,10H2,1-2H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262059
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(=O)NCCO)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H25F2N5O5/c1-4-31-18-9-17(14-5-6-16(29-11-14)24(34)28-7-8-33)30-12-15(18)13-32(25(31)35)23-21(26)19(36-2)10-20(37-3)22(23)27/h5-6,9-12,33H,4,7-8,13H2,1-3H3,(H,28,34)
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM262068
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(C)c2)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-10-13(9-26-27)15-6-14-12(8-25-15)11-28(21(29)22(14)4-5-22)20-18(23)16(30-2)7-17(31-3)19(20)24/h6-10H,4-5,11H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262069
PNG
(1-(5-{3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(5-m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3nnc(C)o3)C2=O)-c2ccc(nc2)C2(CCC2)C#N)c1F
Show InChI InChI=1S/C29H25F2N7O4/c1-16-35-36-24(42-16)14-37-20-9-19(17-5-6-23(34-11-17)29(15-32)7-4-8-29)33-12-18(20)13-38(28(37)39)27-25(30)21(40-2)10-22(41-3)26(27)31/h5-6,9-12H,4,7-8,13-14H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261911
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(c2)C(=O)N2CCOCC2)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-37-21-11-22(38-2)24(30)25(23(21)29)34-15-18-14-32-20(10-19(18)28(3-4-28)27(34)36)16-9-17(13-31-12-16)26(35)33-5-7-39-8-6-33/h9-14H,3-8,15H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262074
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc3NC(=O)Cc3c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C28H24F2N6O4/c1-14-18(13-34(2)33-14)20-9-21-16(11-31-20)12-35(27-25(29)22(39-3)10-23(40-4)26(27)30)28(38)36(21)17-5-6-19-15(7-17)8-24(37)32-19/h5-7,9-11,13H,8,12H2,1-4H3,(H,32,37)
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262083
PNG
(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-me...)
Show SMILES COCCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C1(CCC1)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C28H27F2N5O4/c1-37-10-9-34-20-11-19(17-5-6-23(33-13-17)28(16-31)7-4-8-28)32-14-18(20)15-35(27(34)36)26-24(29)21(38-2)12-22(39-3)25(26)30/h5-6,11-14H,4,7-10,15H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262051
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-1-ethyl-7-(1...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cnn(C)c1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H21F2N5O3/c1-5-27-15-6-14(12-9-25-26(2)10-12)24-8-13(15)11-28(21(27)29)20-18(22)16(30-3)7-17(31-4)19(20)23/h6-10H,5,11H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262069
PNG
(1-(5-{3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(5-m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3nnc(C)o3)C2=O)-c2ccc(nc2)C2(CCC2)C#N)c1F
Show InChI InChI=1S/C29H25F2N7O4/c1-16-35-36-24(42-16)14-37-20-9-19(17-5-6-23(34-11-17)29(15-32)7-4-8-29)33-12-18(20)13-38(28(37)39)27-25(30)21(40-2)10-22(41-3)26(27)31/h5-6,9-12H,4,7-8,13-14H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261900
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(c2)N2CCOCC2)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-35-21-11-22(36-2)24(29)25(23(21)28)33-15-17-13-31-20(10-19(17)27(3-4-27)26(33)34)16-9-18(14-30-12-16)32-5-7-37-8-6-32/h9-14H,3-8,15H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261917
PNG
(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES CNC(=O)c1ccc(cc1)-c1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C26H23F2N3O4/c1-29-24(32)15-6-4-14(5-7-15)18-10-17-16(12-30-18)13-31(25(33)26(17)8-9-26)23-21(27)19(34-2)11-20(35-3)22(23)28/h4-7,10-12H,8-9,13H2,1-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM261919
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C23H22F2N4O3/c1-12-14(11-28(2)27-12)16-7-15-13(9-26-16)10-29(22(30)23(15)5-6-23)21-19(24)17(31-3)8-18(32-4)20(21)25/h7-9,11H,5-6,10H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261919
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C23H22F2N4O3/c1-12-14(11-28(2)27-12)16-7-15-13(9-26-16)10-29(22(30)23(15)5-6-23)21-19(24)17(31-3)8-18(32-4)20(21)25/h7-9,11H,5-6,10H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM261931
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C3CCOC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H25F2N5O4/c1-13-16(11-29(2)28-13)17-7-18-14(9-27-17)10-30(24(32)31(18)15-5-6-35-12-15)23-21(25)19(33-3)8-20(34-4)22(23)26/h7-9,11,15H,5-6,10,12H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM261933
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(C)no3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-6-16(37-30-13)11-32-19-7-18(17-12-31(3)29-14(17)2)28-9-15(19)10-33(25(32)34)24-22(26)20(35-4)8-21(36-5)23(24)27/h6-9,12H,10-11H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261933
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(C)no3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-6-16(37-30-13)11-32-19-7-18(17-12-31(3)29-14(17)2)28-9-15(19)10-33(25(32)34)24-22(26)20(35-4)8-21(36-5)23(24)27/h6-9,12H,10-11H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM261934
PNG
(1-((5-cyclopropylisoxazol-3-yl)methyl)-3-(2,6-difl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(on3)C3CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H26F2N6O4/c1-14-18(13-33(2)31-14)19-8-20-16(10-30-19)11-35(26-24(28)22(37-3)9-23(38-4)25(26)29)27(36)34(20)12-17-7-21(39-32-17)15-5-6-15/h7-10,13,15H,5-6,11-12H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261937
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((2,3-dihyd...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccc4OCCOc4c3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C29H27F2N5O5/c1-16-19(15-34(2)33-16)20-10-21-18(12-32-20)14-36(28-26(30)24(38-3)11-25(39-4)27(28)31)29(37)35(21)13-17-5-6-22-23(9-17)41-8-7-40-22/h5-6,9-12,15H,7-8,13-14H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261938
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES CCn1cc(CN2C(=O)N(Cc3cnc(cc23)-c2cn(C)nc2C)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C26H27F2N7O3/c1-6-33-11-16(9-30-33)12-34-20-7-19(18-14-32(3)31-15(18)2)29-10-17(20)13-35(26(34)36)25-23(27)21(37-4)8-22(38-5)24(25)28/h7-11,14H,6,12-13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261944
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccncn2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H21F2N7O3/c1-13-15(11-31(2)30-13)16-7-17-14(9-28-16)10-32(24(34)33(17)20-5-6-27-12-29-20)23-21(25)18(35-3)8-19(36-4)22(23)26/h5-9,11-12H,10H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261945
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3nnc(C)o3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H23F2N7O4/c1-12-15(10-31(3)30-12)16-6-17-14(8-27-16)9-33(24(34)32(17)11-20-29-28-13(2)37-20)23-21(25)18(35-4)7-19(36-5)22(23)26/h6-8,10H,9,11H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261948
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-7-(3-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(CCN2CCOCC2)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H32F2N6O4/c1-5-34-21-12-20(19-16-33(31-17(19)2)7-6-32-8-10-39-11-9-32)30-14-18(21)15-35(27(34)36)26-24(28)22(37-3)13-23(38-4)25(26)29/h12-14,16H,5-11,15H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261954
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(nc2C)C2CCS(=O)(=O)C2)c1F
Show InChI InChI=1S/C26H26F2N4O5S/c1-14-17(12-32(30-14)16-4-7-38(34,35)13-16)19-8-18-15(10-29-19)11-31(25(33)26(18)5-6-26)24-22(27)20(36-2)9-21(37-3)23(24)28/h8-10,12,16H,4-7,11,13H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261955
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CN(C2)S(C)(=O)=O)c1F
Show InChI InChI=1S/C25H25F2N5O5S/c1-36-19-7-20(37-2)22(27)23(21(19)26)31-10-14-8-28-18(6-17(14)25(4-5-25)24(31)33)15-9-29-32(11-15)16-12-30(13-16)38(3,34)35/h6-9,11,16H,4-5,10,12-13H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261958
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(CN2C(=O)N(Cc3cnc(cc23)-c2cn(C)nc2C)c2c(F)c(OC)cc(OC)c2F)ccn1
Show InChI InChI=1S/C27H26F2N6O4/c1-15-18(14-33(2)32-15)19-9-20-17(11-31-19)13-35(26-24(28)21(37-3)10-22(38-4)25(26)29)27(36)34(20)12-16-6-7-30-23(8-16)39-5/h6-11,14H,12-13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261965
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccncn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H23F2N7O3/c1-14-17(12-32(2)31-14)18-7-19-15(9-29-18)10-34(25(35)33(19)11-16-5-6-28-13-30-16)24-22(26)20(36-3)8-21(37-4)23(24)27/h5-9,12-13H,10-11H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261967
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES CCc1nnc(CN2C(=O)N(Cc3cnc(cc23)-c2cn(C)nc2C)c2c(F)c(OC)cc(OC)c2F)o1
Show InChI InChI=1S/C25H25F2N7O4/c1-6-20-29-30-21(38-20)12-33-17-7-16(15-11-32(3)31-13(15)2)28-9-14(17)10-34(25(33)35)24-22(26)18(36-4)8-19(37-5)23(24)27/h7-9,11H,6,10,12H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261969
PNG
(US9708318, 69)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccncc3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H24F2N6O3/c1-15-18(14-32(2)31-15)19-9-20-17(11-30-19)13-34(26(35)33(20)12-16-5-7-29-8-6-16)25-23(27)21(36-3)10-22(37-4)24(25)28/h5-11,14H,12-13H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%