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Patent code US9708340

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263071
PNG
(US9708340, 64)
Show SMILES COc1cc(Cl)cc(NC(=O)N2CC[C@@H]2C(O)=O)c1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16ClFN2O4/c1-26-15-9-11(19)8-13(16(15)10-2-4-12(20)5-3-10)21-18(25)22-7-6-14(22)17(23)24/h2-5,8-9,14H,6-7H2,1H3,(H,21,25)(H,23,24)/t14-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 20n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263035
PNG
(US9708340, 12)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1
Show InChI InChI=1S/C17H15ClN2O3/c18-12-6-7-13(11-4-2-1-3-5-11)14(10-12)19-17(23)20-9-8-15(20)16(21)22/h1-7,10,15H,8-9H2,(H,19,23)(H,21,22)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263053
PNG
(US9708340, 30)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)c(F)cc1-c1ccccc1
Show InChI InChI=1S/C17H14ClFN2O3/c18-12-9-14(20-17(24)21-7-6-15(21)16(22)23)11(8-13(12)19)10-4-2-1-3-5-10/h1-5,8-9,15H,6-7H2,(H,20,24)(H,22,23)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263056
PNG
(US9708340, 37)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1F
Show InChI InChI=1S/C17H14ClFN2O3/c18-10-5-6-12(11-3-1-2-4-13(11)19)14(9-10)20-17(24)21-8-7-15(21)16(22)23/h1-6,9,15H,7-8H2,(H,20,24)(H,22,23)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 30n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263054
PNG
(US9708340, 31)
Show SMILES Cc1cc(c(NC(=O)N2CC[C@@H]2C(O)=O)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O3/c1-11-9-13(12-5-3-2-4-6-12)15(10-14(11)19)20-18(24)21-8-7-16(21)17(22)23/h2-6,9-10,16H,7-8H2,1H3,(H,20,24)(H,22,23)/t16-/m1/s1
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263057
PNG
(US9708340, 38)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1cccc(F)c1
Show InChI InChI=1S/C17H14ClFN2O3/c18-11-4-5-13(10-2-1-3-12(19)8-10)14(9-11)20-17(24)21-7-6-15(21)16(22)23/h1-5,8-9,15H,6-7H2,(H,20,24)(H,22,23)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263052
PNG
(US9708340, 29)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H14ClFN2O3/c18-11-3-6-13(10-1-4-12(19)5-2-10)14(9-11)20-17(24)21-8-7-15(21)16(22)23/h1-6,9,15H,7-8H2,(H,20,24)(H,22,23)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263070
PNG
(US9708340, 63)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1F
Show InChI InChI=1S/C17H13ClF2N2O3/c18-9-1-3-12(11-4-2-10(19)8-13(11)20)14(7-9)21-17(25)22-6-5-15(22)16(23)24/h1-4,7-8,15H,5-6H2,(H,21,25)(H,23,24)/t15-/m1/s1
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263058
PNG
(US9708340, 39)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C17H13ClF2N2O3/c18-10-1-2-13(9-5-11(19)8-12(20)6-9)14(7-10)21-17(25)22-4-3-15(22)16(23)24/h1-2,5-8,15H,3-4H2,(H,21,25)(H,23,24)/t15-/m1/s1
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UniProtKB/SwissProt

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US Patent
n/an/a 60n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263059
PNG
(US9708340, 52)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccsc1
Show InChI InChI=1S/C16H15ClN2O3S/c17-11-3-4-12(10-5-7-23-9-10)13(8-11)18-16(22)19-6-1-2-14(19)15(20)21/h3-5,7-9,14H,1-2,6H2,(H,18,22)(H,20,21)/t14-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263055
PNG
(US9708340, 36)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1cccc(F)c1F
Show InChI InChI=1S/C17H13ClF2N2O3/c18-9-4-5-10(11-2-1-3-12(19)15(11)20)13(8-9)21-17(25)22-7-6-14(22)16(23)24/h1-5,8,14H,6-7H2,(H,21,25)(H,23,24)/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263061
PNG
(US9708340, 54)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16ClFN2O3/c19-12-5-8-14(11-3-6-13(20)7-4-11)15(10-12)21-18(25)22-9-1-2-16(22)17(23)24/h3-8,10,16H,1-2,9H2,(H,21,25)(H,23,24)/t16-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263049
PNG
(US9708340, 26)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(C2=CCCCC2)c1-c1ccccc1
Show InChI InChI=1S/C24H25ClN2O3/c25-18-14-19(16-8-3-1-4-9-16)22(17-10-5-2-6-11-17)20(15-18)26-24(30)27-13-7-12-21(27)23(28)29/h2,5-6,8,10-11,14-15,21H,1,3-4,7,9,12-13H2,(H,26,30)(H,28,29)/t21-/m1/s1
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US Patent
n/an/a 70n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263051
PNG
(US9708340, 28)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3/c20-16(21)15-10-11-19(15)17(22)18-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,18,22)(H,20,21)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263046
PNG
(US9708340, 23)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(CC=C)c1-c1ccccc1
Show InChI InChI=1S/C21H21ClN2O3/c1-2-7-15-12-16(22)13-17(19(15)14-8-4-3-5-9-14)23-21(27)24-11-6-10-18(24)20(25)26/h2-5,8-9,12-13,18H,1,6-7,10-11H2,(H,23,27)(H,25,26)/t18-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 110n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263041
PNG
(US9708340, 18)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(Cl)c1-c1ccccc1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-12-9-13(20)16(11-5-2-1-3-6-11)14(10-12)21-18(25)22-8-4-7-15(22)17(23)24/h1-3,5-6,9-10,15H,4,7-8H2,(H,21,25)(H,23,24)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263033
PNG
(US9708340, 10)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O3/c19-13-8-9-14(12-5-2-1-3-6-12)15(11-13)20-18(24)21-10-4-7-16(21)17(22)23/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
PDB

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UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263048
PNG
(US9708340, 25)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(C#N)c1-c1ccccc1
Show InChI InChI=1S/C19H16ClN3O3/c20-14-9-13(11-21)17(12-5-2-1-3-6-12)15(10-14)22-19(26)23-8-4-7-16(23)18(24)25/h1-3,5-6,9-10,16H,4,7-8H2,(H,22,26)(H,24,25)/t16-/m1/s1
PDB

UniProtKB/SwissProt

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PC sid
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US Patent
n/an/a 190n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263037
PNG
(US9708340, 14)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(F)cc(F)c1-c1ccccc1
Show InChI InChI=1S/C18H16F2N2O3/c19-12-9-13(20)16(11-5-2-1-3-6-11)14(10-12)21-18(25)22-8-4-7-15(22)17(23)24/h1-3,5-6,9-10,15H,4,7-8H2,(H,21,25)(H,23,24)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 310n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263031
PNG
(US9708340, 8)
Show SMILES OC(=O)[C@H]1CSCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3S/c20-16(21)15-10-23-11-19(15)17(22)18-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,18,22)(H,20,21)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263060
PNG
(US9708340, 53)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1csc2ccccc12
Show InChI InChI=1S/C20H17ClN2O3S/c21-12-7-8-13(15-11-27-18-6-2-1-4-14(15)18)16(10-12)22-20(26)23-9-3-5-17(23)19(24)25/h1-2,4,6-8,10-11,17H,3,5,9H2,(H,22,26)(H,24,25)/t17-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263042
PNG
(US9708340, 19)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(-c2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C24H21ClN2O3/c25-18-14-19(16-8-3-1-4-9-16)22(17-10-5-2-6-11-17)20(15-18)26-24(30)27-13-7-12-21(27)23(28)29/h1-6,8-11,14-15,21H,7,12-13H2,(H,26,30)(H,28,29)/t21-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263049
PNG
(US9708340, 26)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(C2=CCCCC2)c1-c1ccccc1
Show InChI InChI=1S/C24H25ClN2O3/c25-18-14-19(16-8-3-1-4-9-16)22(17-10-5-2-6-11-17)20(15-18)26-24(30)27-13-7-12-21(27)23(28)29/h2,5-6,8,10-11,14-15,21H,1,3-4,7,9,12-13H2,(H,26,30)(H,28,29)/t21-/m1/s1
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n/an/a 530n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263029
PNG
(US9708340, 6)
Show SMILES OC(=O)C1(CCCN1C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H22N2O3/c27-22(28)24(19-12-5-2-6-13-19)16-9-17-26(24)23(29)25-21-15-8-7-14-20(21)18-10-3-1-4-11-18/h1-8,10-15H,9,16-17H2,(H,25,29)(H,27,28)
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n/an/a 620n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263044
PNG
(US9708340, 21)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1c(sc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H18N2O3S/c23-19(24)15-10-6-12-22(15)20(25)21-17-14-9-4-5-11-16(14)26-18(17)13-7-2-1-3-8-13/h1-5,7-9,11,15H,6,10,12H2,(H,21,25)(H,23,24)/t15-/m1/s1
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n/an/a 670n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263062
PNG
(US9708340, 55)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1cccc(Cl)c1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-12-4-1-3-11(9-12)14-7-6-13(20)10-15(14)21-18(25)22-8-2-5-16(22)17(23)24/h1,3-4,6-7,9-10,16H,2,5,8H2,(H,21,25)(H,23,24)/t16-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263034
PNG
(US9708340, 11)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1c(F)cccc1-c1ccccc1
Show InChI InChI=1S/C18H17FN2O3/c19-14-9-4-8-13(12-6-2-1-3-7-12)16(14)20-18(24)21-11-5-10-15(21)17(22)23/h1-4,6-9,15H,5,10-11H2,(H,20,24)(H,22,23)/t15-/m1/s1
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n/an/a 860n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263038
PNG
(US9708340, 15)
Show SMILES CC1(CCCN1C(=O)Nc1ccccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C19H20N2O3/c1-19(17(22)23)12-7-13-21(19)18(24)20-16-11-6-5-10-15(16)14-8-3-2-4-9-14/h2-6,8-11H,7,12-13H2,1H3,(H,20,24)(H,22,23)
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n/an/a 860n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263039
PNG
(US9708340, 16)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(F)ccc1-c1ccccc1
Show InChI InChI=1S/C18H17FN2O3/c19-13-8-9-14(12-5-2-1-3-6-12)15(11-13)20-18(24)21-10-4-7-16(21)17(22)23/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263064
PNG
(US9708340, 57)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1C1=CCCCC1
Show InChI InChI=1S/C18H21ClN2O3/c19-13-8-9-14(12-5-2-1-3-6-12)15(11-13)20-18(24)21-10-4-7-16(21)17(22)23/h5,8-9,11,16H,1-4,6-7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263042
PNG
(US9708340, 19)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(-c2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C24H21ClN2O3/c25-18-14-19(16-8-3-1-4-9-16)22(17-10-5-2-6-11-17)20(15-18)26-24(30)27-13-7-12-21(27)23(28)29/h1-6,8-11,14-15,21H,7,12-13H2,(H,26,30)(H,28,29)/t21-/m1/s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263050
PNG
(US9708340, 27)
Show SMILES OC(=O)[C@@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1
Show InChI InChI=1S/C17H15ClN2O3/c18-12-6-7-13(11-4-2-1-3-5-11)14(10-12)19-17(23)20-9-8-15(20)16(21)22/h1-7,10,15H,8-9H2,(H,19,23)(H,21,22)/t15-/m0/s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263046
PNG
(US9708340, 23)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(CC=C)c1-c1ccccc1
Show InChI InChI=1S/C21H21ClN2O3/c1-2-7-15-12-16(22)13-17(19(15)14-8-4-3-5-9-14)23-21(27)24-11-6-10-18(24)20(25)26/h2-5,8-9,12-13,18H,1,6-7,10-11H2,(H,23,27)(H,25,26)/t18-/m1/s1
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n/an/a 1.29E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263033
PNG
(US9708340, 10)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O3/c19-13-8-9-14(12-5-2-1-3-6-12)15(11-13)20-18(24)21-10-4-7-16(21)17(22)23/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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n/an/a>1.44E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263045
PNG
(US9708340, 22)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1c(sc2ncccc12)-c1ccccc1
Show InChI InChI=1S/C19H17N3O3S/c23-18(24)14-9-5-11-22(14)19(25)21-15-13-8-4-10-20-17(13)26-16(15)12-6-2-1-3-7-12/h1-4,6-8,10,14H,5,9,11H2,(H,21,25)(H,23,24)/t14-/m1/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263047
PNG
(US9708340, 24)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccsc1-c1ccccc1
Show InChI InChI=1S/C16H16N2O3S/c19-15(20)13-7-4-9-18(13)16(21)17-12-8-10-22-14(12)11-5-2-1-3-6-11/h1-3,5-6,8,10,13H,4,7,9H2,(H,17,21)(H,19,20)/t13-/m1/s1
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n/an/a 1.67E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263069
PNG
(US9708340, 62)
Show SMILES CCc1ccc(c(NC(=O)N2CCC[C@@H]2C(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C20H22N2O3/c1-2-14-10-11-16(15-7-4-3-5-8-15)17(13-14)21-20(25)22-12-6-9-18(22)19(23)24/h3-5,7-8,10-11,13,18H,2,6,9,12H2,1H3,(H,21,25)(H,23,24)/t18-/m1/s1
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n/an/a 1.86E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263065
PNG
(US9708340, 58)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccncc1
Show InChI InChI=1S/C17H16ClN3O3/c18-12-3-4-13(11-5-7-19-8-6-11)14(10-12)20-17(24)21-9-1-2-15(21)16(22)23/h3-8,10,15H,1-2,9H2,(H,20,24)(H,22,23)/t15-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263025
PNG
(US9708340, 2)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O3/c19-13-8-9-15(14(11-13)12-5-2-1-3-6-12)20-18(24)21-10-4-7-16(21)17(22)23/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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n/an/a 2.04E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263066
PNG
(US9708340, 59)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-12-5-3-11(4-6-12)14-8-7-13(20)10-15(14)21-18(25)22-9-1-2-16(22)17(23)24/h3-8,10,16H,1-2,9H2,(H,21,25)(H,23,24)/t16-/m1/s1
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n/an/a 2.08E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263068
PNG
(US9708340, 61)
Show SMILES Cc1ccccc1-c1ccc(Cl)cc1NC(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C19H19ClN2O3/c1-12-5-2-3-6-14(12)15-9-8-13(20)11-16(15)21-19(25)22-10-4-7-17(22)18(23)24/h2-3,5-6,8-9,11,17H,4,7,10H2,1H3,(H,21,25)(H,23,24)/t17-/m1/s1
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n/an/a 2.75E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263027
PNG
(US9708340, 4)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H20N2O3/c22-18(23)17-11-6-12-21(17)19(24)20-16-10-5-4-9-15(16)13-14-7-2-1-3-8-14/h1-5,7-10,17H,6,11-13H2,(H,20,24)(H,22,23)/t17-/m1/s1
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n/an/a 3.34E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263067
PNG
(US9708340, 60)
Show SMILES COc1ccc(cc1)-c1ccc(Cl)cc1NC(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C19H19ClN2O4/c1-26-14-7-4-12(5-8-14)15-9-6-13(20)11-16(15)21-19(25)22-10-2-3-17(22)18(23)24/h4-9,11,17H,2-3,10H2,1H3,(H,21,25)(H,23,24)/t17-/m1/s1
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n/an/a 3.45E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263036
PNG
(US9708340, 13)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(ccc1-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)13-8-9-14(12-5-2-1-3-6-12)15(11-13)23-18(27)24-10-4-7-16(24)17(25)26/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,23,27)(H,25,26)/t16-/m1/s1
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n/an/a 3.95E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263054
PNG
(US9708340, 31)
Show SMILES Cc1cc(c(NC(=O)N2CC[C@@H]2C(O)=O)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O3/c1-11-9-13(12-5-3-2-4-6-12)15(10-14(11)19)20-18(24)21-8-7-16(21)17(22)23/h2-6,9-10,16H,7-8H2,1H3,(H,20,24)(H,22,23)/t16-/m1/s1
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UniChem
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n/an/a 5.08E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263040
PNG
(US9708340, 17)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(OC(F)(F)F)ccc1-c1ccccc1
Show InChI InChI=1S/C19H17F3N2O4/c20-19(21,22)28-13-8-9-14(12-5-2-1-3-6-12)15(11-13)23-18(27)24-10-4-7-16(24)17(25)26/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,23,27)(H,25,26)/t16-/m1/s1
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n/an/a 5.71E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263071
PNG
(US9708340, 64)
Show SMILES COc1cc(Cl)cc(NC(=O)N2CC[C@@H]2C(O)=O)c1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16ClFN2O4/c1-26-15-9-11(19)8-13(16(15)10-2-4-12(20)5-3-10)21-18(25)22-7-6-14(22)17(23)24/h2-5,8-9,14H,6-7H2,1H3,(H,21,25)(H,23,24)/t14-/m1/s1
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n/an/a 6.66E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263037
PNG
(US9708340, 14)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(F)cc(F)c1-c1ccccc1
Show InChI InChI=1S/C18H16F2N2O3/c19-12-9-13(20)16(11-5-2-1-3-6-11)14(10-12)21-18(25)22-8-4-7-15(22)17(23)24/h1-3,5-6,9-10,15H,4,7-8H2,(H,21,25)(H,23,24)/t15-/m1/s1
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n/an/a>6.86E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263028
PNG
(US9708340, 5)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1Oc1ccccc1
Show InChI InChI=1S/C18H17ClN2O4/c19-12-8-9-16(25-13-5-2-1-3-6-13)14(11-12)20-18(24)21-10-4-7-15(21)17(22)23/h1-3,5-6,8-9,11,15H,4,7,10H2,(H,20,24)(H,22,23)/t15-/m1/s1
PDB

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n/an/a 7.41E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263024
PNG
(US9708340, 1)
Show SMILES OC(=O)C1CCCCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C19H20N2O3/c22-18(23)17-12-6-7-13-21(17)19(24)20-16-11-5-4-10-15(16)14-8-2-1-3-9-14/h1-5,8-11,17H,6-7,12-13H2,(H,20,24)(H,22,23)
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n/an/a 8.06E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263032
PNG
(US9708340, 9)
Show SMILES OC(=O)[C@@H]1[C@H]2C[C@H]2CN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C19H18N2O3/c22-18(23)17-15-10-13(15)11-21(17)19(24)20-16-9-5-4-8-14(16)12-6-2-1-3-7-12/h1-9,13,15,17H,10-11H2,(H,20,24)(H,22,23)/t13-,15-,17-/m0/s1
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n/an/a 9.10E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263030
PNG
(US9708340, 7)
Show SMILES OC(=O)C1SCCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3S/c20-16(21)15-19(10-11-23-15)17(22)18-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,18,22)(H,20,21)
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n/an/a 9.82E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263059
PNG
(US9708340, 52)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccsc1
Show InChI InChI=1S/C16H15ClN2O3S/c17-11-3-4-12(10-5-7-23-9-10)13(8-11)18-16(22)19-6-1-2-14(19)15(20)21/h3-5,7-9,14H,1-2,6H2,(H,18,22)(H,20,21)/t14-/m1/s1
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n/an/a>1.04E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263043
PNG
(US9708340, 20)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(ccc1-c1ccccc1)C#N
Show InChI InChI=1S/C19H17N3O3/c20-12-13-8-9-15(14-5-2-1-3-6-14)16(11-13)21-19(25)22-10-4-7-17(22)18(23)24/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,21,25)(H,23,24)/t17-/m1/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263063
PNG
(US9708340, 56)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(Cl)cc1NC(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C19H18ClN3O4/c20-13-6-7-14(11-3-1-4-12(9-11)17(21)24)15(10-13)22-19(27)23-8-2-5-16(23)18(25)26/h1,3-4,6-7,9-10,16H,2,5,8H2,(H2,21,24)(H,22,27)(H,25,26)/t16-/m1/s1
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n/an/a 1.11E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4)


(Homo sapiens (Human))
BDBM263026
PNG
(US9708340, 3)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C18H18N2O4/c21-17(22)15-10-6-12-20(15)18(23)19-14-9-4-5-11-16(14)24-13-7-2-1-3-8-13/h1-5,7-9,11,15H,6,10,12H2,(H,19,23)(H,21,22)/t15-/m1/s1
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n/an/a 1.17E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were profiled for activity against human FABP4 (huFABP4) and/or human FABP5 (huFABP5) in Terbium (Tb) time resolved-fluorescence energy tra...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263048
PNG
(US9708340, 25)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(C#N)c1-c1ccccc1
Show InChI InChI=1S/C19H16ClN3O3/c20-14-9-13(11-21)17(12-5-2-1-3-6-12)15(10-14)22-19(26)23-8-4-7-16(23)18(24)25/h1-3,5-6,9-10,16H,4,7-8H2,(H,22,26)(H,24,25)/t16-/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263041
PNG
(US9708340, 18)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)cc(Cl)c1-c1ccccc1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-12-9-13(20)16(11-5-2-1-3-6-11)14(10-12)21-18(25)22-8-4-7-15(22)17(23)24/h1-3,5-6,9-10,15H,4,7-8H2,(H,21,25)(H,23,24)/t15-/m1/s1
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n/an/a 1.82E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263025
PNG
(US9708340, 2)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O3/c19-13-8-9-15(14(11-13)12-5-2-1-3-6-12)20-18(24)21-10-4-7-16(21)17(22)23/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263061
PNG
(US9708340, 54)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H16ClFN2O3/c19-12-5-8-14(11-3-6-13(20)7-4-11)15(10-12)21-18(25)22-9-1-2-16(22)17(23)24/h3-8,10,16H,1-2,9H2,(H,21,25)(H,23,24)/t16-/m1/s1
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n/an/a>2.96E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263053
PNG
(US9708340, 30)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)c(F)cc1-c1ccccc1
Show InChI InChI=1S/C17H14ClFN2O3/c18-12-9-14(20-17(24)21-7-6-15(21)16(22)23)11(8-13(12)19)10-4-2-1-3-5-10/h1-5,8-9,15H,6-7H2,(H,20,24)(H,22,23)/t15-/m1/s1
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n/an/a 4.01E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263060
PNG
(US9708340, 53)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1csc2ccccc12
Show InChI InChI=1S/C20H17ClN2O3S/c21-12-7-8-13(15-11-27-18-6-2-1-4-14(15)18)16(10-12)22-20(26)23-9-3-5-17(23)19(24)25/h1-2,4,6-8,10-11,17H,3,5,9H2,(H,22,26)(H,24,25)/t17-/m1/s1
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n/an/a 4.22E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263028
PNG
(US9708340, 5)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1Oc1ccccc1
Show InChI InChI=1S/C18H17ClN2O4/c19-12-8-9-16(25-13-5-2-1-3-6-13)14(11-12)20-18(24)21-10-4-7-15(21)17(22)23/h1-3,5-6,8-9,11,15H,4,7,10H2,(H,20,24)(H,22,23)/t15-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263039
PNG
(US9708340, 16)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(F)ccc1-c1ccccc1
Show InChI InChI=1S/C18H17FN2O3/c19-13-8-9-14(12-5-2-1-3-6-12)15(11-13)20-18(24)21-10-4-7-16(21)17(22)23/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263051
PNG
(US9708340, 28)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3/c20-16(21)15-10-11-19(15)17(22)18-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,18,22)(H,20,21)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263045
PNG
(US9708340, 22)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1c(sc2ncccc12)-c1ccccc1
Show InChI InChI=1S/C19H17N3O3S/c23-18(24)14-9-5-11-22(14)19(25)21-15-13-8-4-10-20-17(13)26-16(15)12-6-2-1-3-7-12/h1-4,6-8,10,14H,5,9,11H2,(H,21,25)(H,23,24)/t14-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263056
PNG
(US9708340, 37)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1F
Show InChI InChI=1S/C17H14ClFN2O3/c18-10-5-6-12(11-3-1-2-4-13(11)19)14(9-10)20-17(24)21-8-7-15(21)16(22)23/h1-6,9,15H,7-8H2,(H,20,24)(H,22,23)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263030
PNG
(US9708340, 7)
Show SMILES OC(=O)C1SCCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3S/c20-16(21)15-19(10-11-23-15)17(22)18-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,18,22)(H,20,21)
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263032
PNG
(US9708340, 9)
Show SMILES OC(=O)[C@@H]1[C@H]2C[C@H]2CN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C19H18N2O3/c22-18(23)17-15-10-13(15)11-21(17)19(24)20-16-9-5-4-8-14(16)12-6-2-1-3-7-12/h1-9,13,15,17H,10-11H2,(H,20,24)(H,22,23)/t13-,15-,17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263038
PNG
(US9708340, 15)
Show SMILES CC1(CCCN1C(=O)Nc1ccccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C19H20N2O3/c1-19(17(22)23)12-7-13-21(19)18(24)20-16-11-6-5-10-15(16)14-8-3-2-4-9-14/h2-6,8-11H,7,12-13H2,1H3,(H,20,24)(H,22,23)
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263069
PNG
(US9708340, 62)
Show SMILES CCc1ccc(c(NC(=O)N2CCC[C@@H]2C(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C20H22N2O3/c1-2-14-10-11-16(15-7-4-3-5-8-15)17(13-14)21-20(25)22-12-6-9-18(22)19(23)24/h3-5,7-8,10-11,13,18H,2,6,9,12H2,1H3,(H,21,25)(H,23,24)/t18-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263063
PNG
(US9708340, 56)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(Cl)cc1NC(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C19H18ClN3O4/c20-13-6-7-14(11-3-1-4-12(9-11)17(21)24)15(10-13)22-19(27)23-8-2-5-16(23)18(25)26/h1,3-4,6-7,9-10,16H,2,5,8H2,(H2,21,24)(H,22,27)(H,25,26)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263024
PNG
(US9708340, 1)
Show SMILES OC(=O)C1CCCCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C19H20N2O3/c22-18(23)17-12-6-7-13-21(17)19(24)20-16-11-5-4-10-15(16)14-8-2-1-3-9-14/h1-5,8-11,17H,6-7,12-13H2,(H,20,24)(H,22,23)
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263027
PNG
(US9708340, 4)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H20N2O3/c22-18(23)17-11-6-12-21(17)19(24)20-16-10-5-4-9-15(16)13-14-7-2-1-3-8-14/h1-5,7-10,17H,6,11-13H2,(H,20,24)(H,22,23)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263029
PNG
(US9708340, 6)
Show SMILES OC(=O)C1(CCCN1C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H22N2O3/c27-22(28)24(19-12-5-2-6-13-19)16-9-17-26(24)23(29)25-21-15-8-7-14-20(21)18-10-3-1-4-11-18/h1-8,10-15H,9,16-17H2,(H,25,29)(H,27,28)
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263036
PNG
(US9708340, 13)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(ccc1-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)13-8-9-14(12-5-2-1-3-6-12)15(11-13)23-18(27)24-10-4-7-16(24)17(25)26/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,23,27)(H,25,26)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263044
PNG
(US9708340, 21)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1c(sc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H18N2O3S/c23-19(24)15-10-6-12-22(15)20(25)21-17-14-9-4-5-11-16(14)26-18(17)13-7-2-1-3-8-13/h1-5,7-9,11,15H,6,10,12H2,(H,21,25)(H,23,24)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263055
PNG
(US9708340, 36)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1cccc(F)c1F
Show InChI InChI=1S/C17H13ClF2N2O3/c18-9-4-5-10(11-2-1-3-12(19)15(11)20)13(8-9)21-17(25)22-7-6-14(22)16(23)24/h1-5,8,14H,6-7H2,(H,21,25)(H,23,24)/t14-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263065
PNG
(US9708340, 58)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccncc1
Show InChI InChI=1S/C17H16ClN3O3/c18-12-3-4-13(11-5-7-19-8-6-11)14(10-12)20-17(24)21-9-1-2-15(21)16(22)23/h3-8,10,15H,1-2,9H2,(H,20,24)(H,22,23)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263035
PNG
(US9708340, 12)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1
Show InChI InChI=1S/C17H15ClN2O3/c18-12-6-7-13(11-4-2-1-3-5-11)14(10-12)19-17(23)20-9-8-15(20)16(21)22/h1-7,10,15H,8-9H2,(H,19,23)(H,21,22)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263052
PNG
(US9708340, 29)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H14ClFN2O3/c18-11-3-6-13(10-1-4-12(19)5-2-10)14(9-11)20-17(24)21-8-7-15(21)16(22)23/h1-6,9,15H,7-8H2,(H,20,24)(H,22,23)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263067
PNG
(US9708340, 60)
Show SMILES COc1ccc(cc1)-c1ccc(Cl)cc1NC(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C19H19ClN2O4/c1-26-14-7-4-12(5-8-14)15-9-6-13(20)11-16(15)21-19(25)22-10-2-3-17(22)18(23)24/h4-9,11,17H,2-3,10H2,1H3,(H,21,25)(H,23,24)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263026
PNG
(US9708340, 3)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C18H18N2O4/c21-17(22)15-10-6-12-20(15)18(23)19-14-9-4-5-11-16(14)24-13-7-2-1-3-8-13/h1-5,7-9,11,15H,6,10,12H2,(H,19,23)(H,21,22)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263040
PNG
(US9708340, 17)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(OC(F)(F)F)ccc1-c1ccccc1
Show InChI InChI=1S/C19H17F3N2O4/c20-19(21,22)28-13-8-9-14(12-5-2-1-3-6-12)15(11-13)23-18(27)24-10-4-7-16(24)17(25)26/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,23,27)(H,25,26)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263043
PNG
(US9708340, 20)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(ccc1-c1ccccc1)C#N
Show InChI InChI=1S/C19H17N3O3/c20-12-13-8-9-15(14-5-2-1-3-6-14)16(11-13)21-19(25)22-10-4-7-17(22)18(23)24/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,21,25)(H,23,24)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263058
PNG
(US9708340, 39)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C17H13ClF2N2O3/c18-10-1-2-13(9-5-11(19)8-12(20)6-9)14(7-10)21-17(25)22-4-3-15(22)16(23)24/h1-2,5-8,15H,3-4H2,(H,21,25)(H,23,24)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263064
PNG
(US9708340, 57)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1C1=CCCCC1
Show InChI InChI=1S/C18H21ClN2O3/c19-13-8-9-14(12-5-2-1-3-6-12)15(11-13)20-18(24)21-10-4-7-16(21)17(22)23/h5,8-9,11,16H,1-4,6-7,10H2,(H,20,24)(H,22,23)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263066
PNG
(US9708340, 59)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-12-5-3-11(4-6-12)14-8-7-13(20)10-15(14)21-18(25)22-9-1-2-16(22)17(23)24/h3-8,10,16H,1-2,9H2,(H,21,25)(H,23,24)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263031
PNG
(US9708340, 8)
Show SMILES OC(=O)[C@H]1CSCN1C(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3S/c20-16(21)15-10-23-11-19(15)17(22)18-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,18,22)(H,20,21)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263034
PNG
(US9708340, 11)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1c(F)cccc1-c1ccccc1
Show InChI InChI=1S/C18H17FN2O3/c19-14-9-4-8-13(12-6-2-1-3-7-12)16(14)20-18(24)21-11-5-10-15(21)17(22)23/h1-4,6-9,15H,5,10-11H2,(H,20,24)(H,22,23)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263047
PNG
(US9708340, 24)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1ccsc1-c1ccccc1
Show InChI InChI=1S/C16H16N2O3S/c19-15(20)13-7-4-9-18(13)16(21)17-12-8-10-22-14(12)11-5-2-1-3-6-11/h1-3,5-6,8,10,13H,4,7,9H2,(H,17,21)(H,19,20)/t13-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263050
PNG
(US9708340, 27)
Show SMILES OC(=O)[C@@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccccc1
Show InChI InChI=1S/C17H15ClN2O3/c18-12-6-7-13(11-4-2-1-3-5-11)14(10-12)19-17(23)20-9-8-15(20)16(21)22/h1-7,10,15H,8-9H2,(H,19,23)(H,21,22)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263057
PNG
(US9708340, 38)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1cccc(F)c1
Show InChI InChI=1S/C17H14ClFN2O3/c18-11-4-5-13(10-2-1-3-12(19)8-10)14(9-11)20-17(24)21-7-6-15(21)16(22)23/h1-5,8-9,15H,6-7H2,(H,20,24)(H,22,23)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263062
PNG
(US9708340, 55)
Show SMILES OC(=O)[C@H]1CCCN1C(=O)Nc1cc(Cl)ccc1-c1cccc(Cl)c1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-12-4-1-3-11(9-12)14-7-6-13(20)10-15(14)21-18(25)22-8-2-5-16(22)17(23)24/h1,3-4,6-7,9-10,16H,2,5,8H2,(H,21,25)(H,23,24)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263068
PNG
(US9708340, 61)
Show SMILES Cc1ccccc1-c1ccc(Cl)cc1NC(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C19H19ClN2O3/c1-12-5-2-3-6-14(12)15-9-8-13(20)11-16(15)21-19(25)22-10-4-7-17(22)18(23)24/h2-3,5-6,8-9,11,17H,4,7,10H2,1H3,(H,21,25)(H,23,24)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent




Citation and Details
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Ligand-Target Pair
Fatty acid-binding protein 5 (FABP5)


(Homo sapiens (Human))
BDBM263070
PNG
(US9708340, 63)
Show SMILES OC(=O)[C@H]1CCN1C(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1F
Show InChI InChI=1S/C17H13ClF2N2O3/c18-9-1-3-12(11-4-2-10(19)8-13(11)20)14(7-9)21-17(25)22-6-5-15(22)16(23)24/h1-4,7-8,15H,5-6H2,(H,21,25)(H,23,24)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent




Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%