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Patent code US9708359

Compile Data Set for Download or QSAR
Found 143 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Norovirus Polymerase


(Murine norovirus 1)
BDBM263087
PNG
(US9708359, 141)
Show SMILES CC(C)OC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H29N6O9P/c1-7(2)33-19(29)8(3)24-35(30,31)32-6-11-13(26)14(27)18(34-11)25-5-10(16(21)28)12-15(20)22-9(4)23-17(12)25/h5,7-8,11,13-14,18,26-27H,6H2,1-4H3,(H2,21,28)(H2,20,22,23)(H2,24,30,31)/t8-,11+,13+,14+,18+/m0/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263088
PNG
(US9708359, 143)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C35H61N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-48-20-18-21-49-35(45)24(2)40-52(46,47)50-23-27-29(42)30(43)34(51-27)41-22-26(32(37)44)28-31(36)38-25(3)39-33(28)41/h22,24,27,29-30,34,42-43H,4-21,23H2,1-3H3,(H2,37,44)(H2,36,38,39)(H2,40,46,47)/t24-,27+,29+,30+,34+/m0/s1
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n/an/an/an/a 2.63E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263094
PNG
(US9708359, 14)
Show SMILES Cc1nc(N)c2c(I)cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H15IN4O4/c1-4-15-10(14)7-5(13)2-17(11(7)16-4)12-9(20)8(19)6(3-18)21-12/h2,6,8-9,12,18-20H,3H2,1H3,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263100
PNG
(US9708359, 21)
Show SMILES CCOP(=O)(COC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C21H32N5O8P/c1-6-30-35(28,31-7-2)10-29-9-13-15-16(34-21(4,5)33-15)20(32-13)26-8-12(18(23)27)14-17(22)24-11(3)25-19(14)26/h8,13,15-16,20H,6-7,9-10H2,1-5H3,(H2,23,27)(H2,22,24,25)/t13-,15-,16-,20-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263095
PNG
(US9708359, 16 | US9708359, 28)
Show SMILES NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C18H19N5O4S/c19-14-11-9(15(20)28)6-23(18-13(26)12(25)10(7-24)27-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,28)(H2,19,21,22)/t10-,12-,13-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263114
PNG
(US9708359, 39)
Show SMILES CNC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12
Show InChI InChI=1S/C14H19N5O5/c1-5-17-11(15)8-6(13(23)16-2)3-19(12(8)18-5)14-10(22)9(21)7(4-20)24-14/h3,7,9-10,14,20-22H,4H2,1-2H3,(H,16,23)(H2,15,17,18)/t7-,9-,10-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263134
PNG
(US9708359, 73)
Show SMILES CCOP(=O)(CO[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C17H26N5O8P/c1-4-28-31(26,29-5-2)7-27-17-12(24)11(23)16(30-17)22-6-9(14(19)25)10-13(18)20-8(3)21-15(10)22/h6,11-12,16-17,23-24H,4-5,7H2,1-3H3,(H2,19,25)(H2,18,20,21)/t11-,12+,16-,17+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263138
PNG
(US9708359, 83)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)nc(N)c12
Show InChI InChI=1S/C12H16N6O5/c13-8-5-3(9(14)22)1-18(10(5)17-12(15)16-8)11-7(21)6(20)4(2-19)23-11/h1,4,6-7,11,19-21H,2H2,(H2,14,22)(H4,13,15,16,17)/t4-,6-,7-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263151
PNG
(US9708359, 106)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@@](CO)([N-][N+]#N)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H14N8O4/c1-5-17-10(15)7-6(2-14)3-21(11(7)18-5)12-8(23)9(24)13(4-22,25-12)19-20-16/h3,8-9,12,22-24H,4H2,1H3,(H2,15,17,18)/t8-,9+,12-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263153
PNG
(US9708359, 110)
Show SMILES Cc1nc(N)c2c(cn([C@H]3CCCO3)c2n1)C(N)=O
Show InChI InChI=1S/C12H15N5O2/c1-6-15-10(13)9-7(11(14)18)5-17(12(9)16-6)8-3-2-4-19-8/h5,8H,2-4H2,1H3,(H2,14,18)(H2,13,15,16)/t8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263158
PNG
(US9708359, 120)
Show SMILES Cc1nc(Cl)c2ccn([C@H]3CC=CO3)c2n1
Show InChI InChI=1S/C11H10ClN3O/c1-7-13-10(12)8-4-5-15(11(8)14-7)9-3-2-6-16-9/h2,4-6,9H,3H2,1H3/t9-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263159
PNG
(US9708359, 121)
Show SMILES Cc1nc(N)c2ccn([C@H]3CC=CO3)c2n1
Show InChI InChI=1S/C11H12N4O/c1-7-13-10(12)8-4-5-15(11(8)14-7)9-3-2-6-16-9/h2,4-6,9H,3H2,1H3,(H2,12,13,14)/t9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263165
PNG
(US9708359, 129)
Show SMILES CC(=O)OC[C@H]1O[C@H]([C@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H23N5O8/c1-7-22-16(20)13-11(17(21)28)5-24(18(13)23-7)19-15(31-10(4)27)14(30-9(3)26)12(32-19)6-29-8(2)25/h5,12,14-15,19H,6H2,1-4H3,(H2,21,28)(H2,20,22,23)/t12-,14-,15-,19-/m1/s1
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n/an/an/an/a 8.87E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263184
PNG
(US9708359, 53)
Show SMILES CCOP(=O)(CO[C@H](CO)Cn1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C16H26N5O6P/c1-4-26-28(24,27-5-2)9-25-11(8-22)6-21-7-12(15(18)23)13-14(17)19-10(3)20-16(13)21/h7,11,22H,4-6,8-9H2,1-3H3,(H2,18,23)(H2,17,19,20)/t11-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263189
PNG
(US9708359, 62)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@H]1OC(C)([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H28N6O6/c1-7(2)12(20)18(29)30-6-10-13(26)14(27)19(4,31-10)25-5-9(16(22)28)11-15(21)23-8(3)24-17(11)25/h5,7,10,12-14,26-27H,6,20H2,1-4H3,(H2,22,28)(H2,21,23,24)/t10-,12+,13-,14-,19?/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263190
PNG
(US9708359, 64)
Show SMILES CCOP(=O)(COC(CO)Cn1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C16H26N5O6P/c1-4-26-28(24,27-5-2)9-25-11(8-22)6-21-7-12(15(18)23)13-14(17)19-10(3)20-16(13)21/h7,11,22H,4-6,8-9H2,1-3H3,(H2,18,23)(H2,17,19,20)
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263202
PNG
(US9708359, 99)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(CO)nc(N)c12
Show InChI InChI=1S/C13H17N5O6/c14-10-7-4(11(15)23)1-18(12(7)17-6(3-20)16-10)13-9(22)8(21)5(2-19)24-13/h1,5,8-9,13,19-22H,2-3H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263210
PNG
(US9708359, 119)
Show SMILES CCOP(=O)(CC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C18H28N5O7P/c1-4-28-31(27,29-5-2)7-6-11-13(24)14(25)18(30-11)23-8-10(16(20)26)12-15(19)21-9(3)22-17(12)23/h8,11,13-14,18,24-25H,4-7H2,1-3H3,(H2,20,26)(H2,19,21,22)/t11-,13-,14-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263101
PNG
(US9708359, 22)
Show SMILES CCCCCCCCCCCCCCCOCCCOP(O)(=O)COC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C35H60N5O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-19-44-20-18-21-46-50(42,43)24-45-23-27-29-30(49-35(3,4)48-29)34(47-27)40-22-26(32(37)41)28-31(36)38-25(2)39-33(28)40/h22,27,29-30,34H,5-21,23-24H2,1-4H3,(H2,37,41)(H,42,43)(H2,36,38,39)/t27-,29-,30-,34-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263135
PNG
(US9708359, 78)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@@H]4OCP(O)(=O)O[C@H]4[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N5O7P/c1-4-16-9(14)6-5(10(15)20)2-18(11(6)17-4)12-7(19)8-13(24-12)23-3-26(21,22)25-8/h2,7-8,12-13,19H,3H2,1H3,(H2,15,20)(H,21,22)(H2,14,16,17)/t7-,8+,12-,13+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263144
PNG
(US9708359, 93)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@H]1O[C@@H](n2cc(C(N)=O)c3c(N)nc(C)nc23)[C@](C)(O)[C@@H]1OC(=O)C(N)C(C)C
Show InChI InChI=1S/C24H37N7O7/c1-9(2)15(25)21(33)36-8-13-17(38-22(34)16(26)10(3)4)24(6,35)23(37-13)31-7-12(19(28)32)14-18(27)29-11(5)30-20(14)31/h7,9-10,13,15-17,23,35H,8,25-26H2,1-6H3,(H2,28,32)(H2,27,29,30)/t13-,15+,16?,17-,23-,24-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263161
PNG
(US9708359, 123)
Show SMILES CCOP(=O)(CCO[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#N)c2c(Cl)nc(C)nc12)OCC
Show InChI InChI=1S/C18H24ClN4O7P/c1-4-28-31(26,29-5-2)7-6-27-18-14(25)13(24)17(30-18)23-9-11(8-20)12-15(19)21-10(3)22-16(12)23/h9,13-14,17-18,24-25H,4-7H2,1-3H3/t13-,14+,17-,18+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263162
PNG
(US9708359, 124)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](O)C=C3)c2n1)C(N)=O
Show InChI InChI=1S/C12H13N5O3/c1-5-15-10(13)9-6(11(14)19)4-17(12(9)16-5)7-2-3-8(18)20-7/h2-4,7-8,18H,1H3,(H2,14,19)(H2,13,15,16)/t7-,8+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263173
PNG
(US9708359, 142)
Show SMILES CCCCCCCCCCCCCCCOCCCOC(=O)C(C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCc1ccccc1C
Show InChI InChI=1S/C42H67N6O10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-19-23-54-24-20-25-55-42(52)30(3)47-59(53,56-27-32-22-18-17-21-29(32)2)57-28-34-36(49)37(50)41(58-34)48-26-33(39(44)51)35-38(43)45-31(4)46-40(35)48/h17-18,21-22,26,30,34,36-37,41,49-50H,5-16,19-20,23-25,27-28H2,1-4H3,(H2,44,51)(H,47,53)(H2,43,45,46)/t30?,34-,36-,37-,41-,59?/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263178
PNG
(US9708359, 23)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H20N5O8P/c1-5-17-11(15)8-6(12(16)22)2-19(13(8)18-5)14-10(21)9(20)7(27-14)3-26-4-28(23,24)25/h2,7,9-10,14,20-21H,3-4H2,1H3,(H2,16,22)(H2,15,17,18)(H2,23,24,25)/t7-,9-,10-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 2.65E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263073
PNG
(US9708359, 2)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C18H26N6O6/c1-6(2)11(19)18(28)29-5-9-12(25)13(26)17(30-9)24-4-8(15(21)27)10-14(20)22-7(3)23-16(10)24/h4,6,9,11-13,17,25-26H,5,19H2,1-3H3,(H2,21,27)(H2,20,22,23)/t9-,11+,12-,13-,17-/m1/s1
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n/an/an/an/a 3.03E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263078
PNG
(US9708359, 71)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N5O8P/c1-4-16-10(14)7-5(11(15)21)2-18(12(7)17-4)13-9(20)8(19)6(26-13)3-25-27(22,23)24/h2,6,8-9,13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 3.15E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/m1/s1
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n/an/an/an/a 3.89E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263099
PNG
(US9708359, 20)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@H]4OC(C)(C)O[C@@H]34)c2n1)C(N)=O
Show InChI InChI=1S/C16H21N5O5/c1-6-19-12(17)9-7(13(18)23)4-21(14(9)20-6)15-11-10(8(5-22)24-15)25-16(2,3)26-11/h4,8,10-11,15,22H,5H2,1-3H3,(H2,18,23)(H2,17,19,20)/t8-,10-,11-,15-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263120
PNG
(US9708359, 46)
Show SMILES Cc1nc(N)c2ccnc2n1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263121
PNG
(US9708359, 47)
Show SMILES COc1nc(C)nc2n(cc(CN)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H20N4O5/c1-6-16-12-9(13(17-6)22-2)7(3-15)4-18(12)14-11(21)10(20)8(5-19)23-14/h4,8,10-11,14,19-21H,3,5,15H2,1-2H3/t8-,10-,11-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263125
PNG
(US9708359, 51)
Show SMILES C[C@H](O)Cn1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C11H15N5O2/c1-5(17)3-16-4-7(10(13)18)8-9(12)14-6(2)15-11(8)16/h4-5,17H,3H2,1-2H3,(H2,13,18)(H2,12,14,15)/t5-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263129
PNG
(US9708359, 65)
Show SMILES COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)OC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C30H33N5O7/c1-14(16-6-7-18-11-19(38-5)9-8-17(18)10-16)29(37)39-13-21-23-24(42-30(3,4)41-23)28(40-21)35-12-20(26(32)36)22-25(31)33-15(2)34-27(22)35/h6-12,14,21,23-24,28H,13H2,1-5H3,(H2,32,36)(H2,31,33,34)/t14-,21-,23-,24-,28-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263139
PNG
(US9708359, 84)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)S(O)(=O)=O
Show InChI InChI=1S/C12H16N4O7S/c1-4-14-10(13)7-6(24(20,21)22)2-16(11(7)15-4)12-9(19)8(18)5(3-17)23-12/h2,5,8-9,12,17-19H,3H2,1H3,(H2,13,14,15)(H,20,21,22)/t5-,8-,9-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263152
PNG
(US9708359, 108)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CN)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N6O4/c1-4-17-10(15)7-5(11(16)22)3-19(12(7)18-4)13-9(21)8(20)6(2-14)23-13/h3,6,8-9,13,20-21H,2,14H2,1H3,(H2,16,22)(H2,15,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263163
PNG
(US9708359, 125)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](OCCP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H20N5O8P/c1-5-17-10(15)7-6(11(16)22)4-19(12(7)18-5)13-8(20)9(21)14(27-13)26-2-3-28(23,24)25/h4,8-9,13-14,20-21H,2-3H2,1H3,(H2,16,22)(H2,15,17,18)(H2,23,24,25)/t8-,9+,13-,14+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263164
PNG
(US9708359, 128)
Show SMILES CC(=O)Nc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
Show InChI InChI=1S/C21H25N5O9/c1-8-23-19(25-9(2)27)15-13(18(22)31)6-26(20(15)24-8)21-17(34-12(5)30)16(33-11(4)29)14(35-21)7-32-10(3)28/h6,14,16-17,21H,7H2,1-5H3,(H2,22,31)(H,23,24,25,27)/t14-,16-,17-,21-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263206
PNG
(US9708359, 109)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8+,9+,13+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263080
PNG
(US9708359, 76)
Show SMILES CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C34H38N6O8/c1-16(2)12-24(39-34(45)47-14-23-20-10-6-4-8-18(20)19-9-5-7-11-21(19)23)33(44)46-15-25-27(41)28(42)32(48-25)40-13-22(30(36)43)26-29(35)37-17(3)38-31(26)40/h4-11,13,16,23-25,27-28,32,41-42H,12,14-15H2,1-3H3,(H2,36,43)(H,39,45)(H2,35,37,38)/t24-,25+,27+,28+,32+/m0/s1
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n/an/an/an/a 1.64E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/m1/s1
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n/an/an/an/a 3.36E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263091
PNG
(US9708359, 8)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2[n+]1[O-])C(N)=O
Show InChI InChI=1S/C13H17N5O6/c1-4-16-10(14)7-5(11(15)22)2-17(12(7)18(4)23)13-9(21)8(20)6(3-19)24-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,14,16)(H2,15,22)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 2.36E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263106
PNG
(US9708359, 31)
Show SMILES Cc1nc(O)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H14N4O5/c1-5-15-11-8(12(21)16-5)6(2-14)3-17(11)13-10(20)9(19)7(4-18)22-13/h3,7,9-10,13,18-20H,4H2,1H3,(H,15,16,21)/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263110
PNG
(US9708359, 35)
Show SMILES Cc1ncc2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N4O5/c1-5-15-2-6-7(11(14)21)3-17(12(6)16-5)13-10(20)9(19)8(4-18)22-13/h2-3,8-10,13,18-20H,4H2,1H3,(H2,14,21)/t8-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263112
PNG
(US9708359, 37)
Show SMILES CN(C)c1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H21N5O5/c1-6-17-13(19(2)3)9-7(12(16)24)4-20(14(9)18-6)15-11(23)10(22)8(5-21)25-15/h4,8,10-11,15,21-23H,5H2,1-3H3,(H2,16,24)/t8-,10-,11-,15-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263118
PNG
(US9708359, 44)
Show SMILES Cc1nc(N)c2c(C(N)=O)c(Br)n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C13H16BrN5O5/c1-3-17-10(15)6-5(11(16)23)9(14)19(12(6)18-3)13-8(22)7(21)4(2-20)24-13/h4,7-8,13,20-22H,2H2,1H3,(H2,16,23)(H2,15,17,18)/t4-,7-,8-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263130
PNG
(US9708359, 66)
Show SMILES COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C27H29N5O7/c1-12(14-4-5-16-9-17(37-3)7-6-15(16)8-14)27(36)38-11-19-21(33)22(34)26(39-19)32-10-18(24(29)35)20-23(28)30-13(2)31-25(20)32/h4-10,12,19,21-22,26,33-34H,11H2,1-3H3,(H2,29,35)(H2,28,30,31)/t12-,19-,21-,22-,26-/m1/s1
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n/an/an/an/a 2.02E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263130
PNG
(US9708359, 66)
Show SMILES COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C27H29N5O7/c1-12(14-4-5-16-9-17(37-3)7-6-15(16)8-14)27(36)38-11-19-21(33)22(34)26(39-19)32-10-18(24(29)35)20-23(28)30-13(2)31-25(20)32/h4-10,12,19,21-22,26,33-34H,11H2,1-3H3,(H2,29,35)(H2,28,30,31)/t12-,19-,21-,22-,26-/m1/s1
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n/an/an/an/a 7.18E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263122
PNG
(US9708359, 48 | US9708359, 49 | US9708359, 81)
Show SMILES Cc1nc(N)c2ccn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H16N4O4/c1-5-14-10(13)6-2-3-16(11(6)15-5)12-9(19)8(18)7(4-17)20-12/h2-3,7-9,12,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,9-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263145
PNG
(US9708359, 94)
Show SMILES Cc1nc(NO)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O6/c1-4-15-11(17-23)7-5(10(14)22)2-18(12(7)16-4)13-9(21)8(20)6(3-19)24-13/h2,6,8-9,13,19-21,23H,3H2,1H3,(H2,14,22)(H,15,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263148
PNG
(US9708359, 100)
Show SMILES COC(=N)c1cn([C@@H]2O[C@@](CO)([N-][N+]#N)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12
Show InChI InChI=1S/C14H18N8O5/c1-5-18-10(15)7-6(11(16)26-2)3-22(12(7)19-5)13-8(24)9(25)14(4-23,27-13)20-21-17/h3,8-9,13,16,23-25H,4H2,1-2H3,(H2,15,18,19)/t8-,9+,13-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263149
PNG
(US9708359, 103)
Show SMILES COC(=N)c1cn([C@@H]2O[C@H](COS(=O)(=O)CCCCl)[C@H]3OC(C)(C)O[C@@H]23)c2nc(C)nc(N)c12
Show InChI InChI=1S/C20H28ClN5O7S/c1-10-24-16(22)13-11(17(23)29-4)8-26(18(13)25-10)19-15-14(32-20(2,3)33-15)12(31-19)9-30-34(27,28)7-5-6-21/h8,12,14-15,19,23H,5-7,9H2,1-4H3,(H2,22,24,25)/t12-,14-,15-,19-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263167
PNG
(US9708359, 131)
Show SMILES CCCC(CCC)C(=O)Nc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H31N5O6/c1-4-6-11(7-5-2)20(31)25-18-14-12(17(22)30)8-26(19(14)24-10(3)23-18)21-16(29)15(28)13(9-27)32-21/h8,11,13,15-16,21,27-29H,4-7,9H2,1-3H3,(H2,22,30)(H,23,24,25,31)/t13-,15-,16-,21-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263168
PNG
(US9708359, 132)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C25H33N6O9P/c1-12(2)38-25(35)13(3)30-41(36,40-15-8-6-5-7-9-15)37-11-17-19(32)20(33)24(39-17)31-10-16(22(27)34)18-21(26)28-14(4)29-23(18)31/h5-10,12-13,17,19-20,24,32-33H,11H2,1-4H3,(H2,27,34)(H,30,36)(H2,26,28,29)/t13-,17+,19+,20+,24+,41?/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263169
PNG
(US9708359, 134)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@@H]2OC(=O)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C26H31N6O10P/c1-12(2)38-25(34)13(3)31-43(36,42-15-8-6-5-7-9-15)37-11-17-19-20(41-26(35)40-19)24(39-17)32-10-16(22(28)33)18-21(27)29-14(4)30-23(18)32/h5-10,12-13,17,19-20,24H,11H2,1-4H3,(H2,28,33)(H,31,36)(H2,27,29,30)/t13-,17+,19+,20+,24+,43?/m0/s1
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n/an/an/an/a 6.84E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263174
PNG
(US9708359, 144)
Show SMILES Cc1nc(N)c2c(C(N)=O)c(C=C)n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H19N5O5/c1-3-6-8(13(17)24)9-12(16)18-5(2)19-14(9)20(6)15-11(23)10(22)7(4-21)25-15/h3,7,10-11,15,21-23H,1,4H2,2H3,(H2,17,24)(H2,16,18,19)/t7-,10-,11-,15-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263181
PNG
(US9708359, 26 | US9708359, 80)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)C(F)(F)F
Show InChI InChI=1S/C13H14F3N5O5/c14-13(15,16)12-19-8(17)5-3(9(18)25)1-21(10(5)20-12)11-7(24)6(23)4(2-22)26-11/h1,4,6-7,11,22-24H,2H2,(H2,18,25)(H2,17,19,20)/t4-,6-,7-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263201
PNG
(US9708359, 97)
Show SMILES C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C13H17N5O4/c1-4-8(19)9(20)13(22-4)18-3-6(11(15)21)7-10(14)16-5(2)17-12(7)18/h3-4,8-9,13,19-20H,1-2H3,(H2,15,21)(H2,14,16,17)/t4-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263209
PNG
(US9708359, 118)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C12H15N5O5/c1-3-15-8(13)5-4(9(14)20)2-17(10(5)16-3)11-6(18)7(19)12(21)22-11/h2,6-7,11-12,18-19,21H,1H3,(H2,14,20)(H2,13,15,16)/t6-,7+,11-,12+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263074
PNG
(US9708359, 3)
Show SMILES C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C16H22N6O6/c1-5(17)16(26)27-4-8-10(23)11(24)15(28-8)22-3-7(13(19)25)9-12(18)20-6(2)21-14(9)22/h3,5,8,10-11,15,23-24H,4,17H2,1-2H3,(H2,19,25)(H2,18,20,21)/t5-,8+,10+,11+,15+/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263084
PNG
(US9708359, 133)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C33H45N6O11P/c1-16(2)31(41)48-25-23(15-45-51(44,50-21-12-10-9-11-13-21)38-19(7)33(43)46-18(5)6)47-30(26(25)49-32(42)17(3)4)39-14-22(28(35)40)24-27(34)36-20(8)37-29(24)39/h9-14,16-19,23,25-26,30H,15H2,1-8H3,(H2,35,40)(H,38,44)(H2,34,36,37)/t19-,23+,25+,26+,30+,51?/m0/s1
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n/an/an/an/a 2.57E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263089
PNG
(US9708359, 145)
Show SMILES CCCCCCCCC(=O)Oc1ccc(COP(=O)(OCc2ccc(OC(=O)CCCCCCCC)cc2)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cc(C(N)=O)c3c(N)nc(C)nc23)cc1
Show InChI InChI=1S/C45H63N5O15P2/c1-4-6-8-10-12-14-16-37(51)62-33-22-18-31(19-23-33)27-60-67(58,61-28-32-20-24-34(25-21-32)63-38(52)17-15-13-11-9-7-5-2)65-66(56,57)59-29-36-40(53)41(54)45(64-36)50-26-35(43(47)55)39-42(46)48-30(3)49-44(39)50/h18-26,36,40-41,45,53-54H,4-17,27-29H2,1-3H3,(H2,47,55)(H,56,57)(H2,46,48,49)/t36-,40-,41-,45-/m1/s1
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n/an/an/an/a 7.40E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263090
PNG
(US9708359, 7)
Show SMILES Cc1nc(O)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N4O6/c1-4-15-11-7(12(22)16-4)5(10(14)21)2-17(11)13-9(20)8(19)6(3-18)23-13/h2,6,8-9,13,18-20H,3H2,1H3,(H2,14,21)(H,15,16,22)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 5.38E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263102
PNG
(US9708359, 27)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C20H21N5O4/c1-11-23-18(22)15-13(7-21)8-25(19(15)24-11)20-17(27)16(26)14(29-20)10-28-9-12-5-3-2-4-6-12/h2-6,8,14,16-17,20,26-27H,9-10H2,1H3,(H2,22,23,24)/t14-,16-,17-,20-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263122
PNG
(US9708359, 48 | US9708359, 49 | US9708359, 81)
Show SMILES Cc1nc(N)c2ccn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H16N4O4/c1-5-14-10(13)6-2-3-16(11(6)15-5)12-9(19)8(18)7(4-17)20-12/h2-3,7-9,12,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,9-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263126
PNG
(US9708359, 54)
Show SMILES C[C@H](O)Cn1ccc2c(N)nc(C)nc12
Show InChI InChI=1S/C10H14N4O/c1-6(15)5-14-4-3-8-9(11)12-7(2)13-10(8)14/h3-4,6,15H,5H2,1-2H3,(H2,11,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263127
PNG
(US9708359, 61)
Show SMILES COc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](COC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)[C@@H](O)[C@@]1(C)O
Show InChI InChI=1S/C25H37N5O9/c1-11(2)16(29-23(34)39-24(4,5)6)21(33)37-10-14-17(31)25(7,35)22(38-14)30-9-13(18(26)32)15-19(30)27-12(3)28-20(15)36-8/h9,11,14,16-17,22,31,35H,10H2,1-8H3,(H2,26,32)(H,29,34)/t14-,16+,17-,22-,25-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263150
PNG
(US9708359, 104)
Show SMILES COC(=N)c1cn([C@@H]2O[C@H](C[N-][N+]#N)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12
Show InChI InChI=1S/C14H18N8O4/c1-5-19-11(15)8-6(12(16)25-2)4-22(13(8)20-5)14-10(24)9(23)7(26-14)3-18-21-17/h4,7,9-10,14,16,23-24H,3H2,1-2H3,(H2,15,19,20)/t7-,9-,10-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263175
PNG
(US9708359, 9)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9+,13-/m1/s1
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n/an/an/an/a 5.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263179
PNG
(US9708359, 24)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C33H58N5O9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-44-19-17-20-46-48(42,43)23-45-22-26-28(39)29(40)33(47-26)38-21-25(31(35)41)27-30(34)36-24(2)37-32(27)38/h21,26,28-29,33,39-40H,3-20,22-23H2,1-2H3,(H2,35,41)(H,42,43)(H2,34,36,37)/t26-,28-,29-,33-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263187
PNG
(US9708359, 58)
Show SMILES CCOP(=O)(CO[C@H](C)Cn1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C16H26N5O5P/c1-5-25-27(23,26-6-2)9-24-10(3)7-21-8-12(15(18)22)13-14(17)19-11(4)20-16(13)21/h8,10H,5-7,9H2,1-4H3,(H2,18,22)(H2,17,19,20)/t10-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263133
PNG
(US9708359, 70 | US9708359, 72)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](OCP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N5O8P/c1-4-16-9(14)6-5(10(15)21)2-18(11(6)17-4)12-7(19)8(20)13(26-12)25-3-27(22,23)24/h2,7-8,12-13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t7-,8+,12-,13+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263199
PNG
(US9708359, 90)
Show SMILES CC#Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C15H17N5O5/c1-2-3-8-18-12(16)9-6(13(17)24)4-20(14(9)19-8)15-11(23)10(22)7(5-21)25-15/h4,7,10-11,15,21-23H,5H2,1H3,(H2,17,24)(H2,16,18,19)/t7-,10-,11-,15-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263207
PNG
(US9708359, 112)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](N=[N+]=[N-])[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N8O4/c1-4-17-10(14)7-5(11(15)24)2-21(12(7)18-4)13-9(23)8(19-20-16)6(3-22)25-13/h2,6,8-9,13,22-23H,3H2,1H3,(H2,15,24)(H2,14,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263075
PNG
(US9708359, 4)
Show SMILES CCCCCCCCCCCCCCCCOCCC(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C32H53N5O7/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-42-19-17-25(38)43-21-24-27(39)28(40)32(44-24)37-20-23(30(34)41)26-29(33)35-22(2)36-31(26)37/h20,24,27-28,32,39-40H,3-19,21H2,1-2H3,(H2,34,41)(H2,33,35,36)/t24-,27-,28-,32-/m1/s1
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n/an/an/an/a 3.50E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 3.08E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263081
PNG
(US9708359, 107)
Show SMILES C[C@H](NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H33N6O9P/c1-16(29(39)41-14-18-9-5-3-6-10-18)34-45(40,44-19-11-7-4-8-12-19)42-15-21-23(36)24(37)28(43-21)35-13-20(26(31)38)22-25(30)32-17(2)33-27(22)35/h3-13,16,21,23-24,28,36-37H,14-15H2,1-2H3,(H2,31,38)(H,34,40)(H2,30,32,33)/t16-,21+,23+,24+,28+,45?/m0/s1
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n/an/an/an/a 1.81E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263085
PNG
(US9708359, 137)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCc1ccccc1C
Show InChI InChI=1S/C27H37N6O9P/c1-13(2)41-27(37)15(4)32-43(38,39-11-17-9-7-6-8-14(17)3)40-12-19-21(34)22(35)26(42-19)33-10-18(24(29)36)20-23(28)30-16(5)31-25(20)33/h6-10,13,15,19,21-22,26,34-35H,11-12H2,1-5H3,(H2,29,36)(H,32,38)(H2,28,30,31)/t15-,19+,21+,22+,26+,43?/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263095
PNG
(US9708359, 16 | US9708359, 28)
Show SMILES NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C18H19N5O4S/c19-14-11-9(15(20)28)6-23(18-13(26)12(25)10(7-24)27-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,28)(H2,19,21,22)/t10-,12-,13-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263097
PNG
(US9708359, 18)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](COCc3ccccc3)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C25H25N5O5/c26-21-18-16(22(27)33)11-30(24(18)29-23(28-21)15-9-5-2-6-10-15)25-20(32)19(31)17(35-25)13-34-12-14-7-3-1-4-8-14/h1-11,17,19-20,25,31-32H,12-13H2,(H2,27,33)(H2,26,28,29)/t17-,19-,20-,25-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263098
PNG
(US9708359, 19)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C20H23N5O5/c1-10-23-17(21)14-12(18(22)28)7-25(19(14)24-10)20-16(27)15(26)13(30-20)9-29-8-11-5-3-2-4-6-11/h2-7,13,15-16,20,26-27H,8-9H2,1H3,(H2,22,28)(H2,21,23,24)/t13-,15-,16-,20-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263104
PNG
(US9708359, 29)
Show SMILES Cc1nc(Cl)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H13ClN4O4/c1-5-16-11(14)8-6(2-15)3-18(12(8)17-5)13-10(21)9(20)7(4-19)22-13/h3,7,9-10,13,19-21H,4H2,1H3/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263116
PNG
(US9708359, 42)
Show SMILES COc1nc(C)nc2n(cc(I)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H16IN3O5/c1-5-15-11-8(12(16-5)21-2)6(14)3-17(11)13-10(20)9(19)7(4-18)22-13/h3,7,9-10,13,18-20H,4H2,1-2H3/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263117
PNG
(US9708359, 43)
Show SMILES CSc1nc(C)nc2n(cc(I)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H16IN3O4S/c1-5-15-11-8(12(16-5)22-2)6(14)3-17(11)13-10(20)9(19)7(4-18)21-13/h3,7,9-10,13,18-20H,4H2,1-2H3/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263119
PNG
(US9708359, 45)
Show SMILES COC(=O)c1cnc2nc(C)nc(Cl)c12
Show InChI InChI=1S/C9H7ClN3O2/c1-4-12-7(10)6-5(9(14)15-2)3-11-8(6)13-4/h3H,1-2H3
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263122
PNG
(US9708359, 48 | US9708359, 49 | US9708359, 81)
Show SMILES Cc1nc(N)c2ccn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H16N4O4/c1-5-14-10(13)6-2-3-16(11(6)15-5)12-9(19)8(18)7(4-17)20-12/h2-3,7-9,12,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,9-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263131
PNG
(US9708359, 68 | US9708359, 69)
Show SMILES CCOP(=O)(CO[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#N)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C17H24N5O7P/c1-4-27-30(25,28-5-2)8-26-17-13(24)12(23)16(29-17)22-7-10(6-18)11-14(19)20-9(3)21-15(11)22/h7,12-13,16-17,23-24H,4-5,8H2,1-3H3,(H2,19,20,21)/t12-,13+,16-,17+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263137
PNG
(US9708359, 82)
Show SMILES Cc1nc(N)c2ccn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C19H22N4O4/c1-11-21-17(20)13-7-8-23(18(13)22-11)19-16(25)15(24)14(27-19)10-26-9-12-5-3-2-4-6-12/h2-8,14-16,19,24-25H,9-10H2,1H3,(H2,20,21,22)/t14-,15-,16-,19-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263146
PNG
(US9708359, 95)
Show SMILES Cc1nc(NN)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N6O5/c1-4-16-11(18-15)7-5(10(14)23)2-19(12(7)17-4)13-9(22)8(21)6(3-20)24-13/h2,6,8-9,13,20-22H,3,15H2,1H3,(H2,14,23)(H,16,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263154
PNG
(US9708359, 114 | US9708359, 115)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](O)C=C3)c2n1)C#N
Show InChI InChI=1S/C12H11N5O2/c1-6-15-11(14)10-7(4-13)5-17(12(10)16-6)8-2-3-9(18)19-8/h2-3,5,8-9,18H,1H3,(H2,14,15,16)/t8-,9+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263156
PNG
(US9708359, 116)
Show SMILES CCOP(=O)(CO[C@H]1O[C@H](C=C1)n1cc(C#N)c2c(Cl)nc(C)nc12)OCC
Show InChI InChI=1S/C17H20ClN4O5P/c1-4-25-28(23,26-5-2)10-24-14-7-6-13(27-14)22-9-12(8-19)15-16(18)20-11(3)21-17(15)22/h6-7,9,13-14H,4-5,10H2,1-3H3/t13-,14+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263170
PNG
(US9708359, 136)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(=O)(NCc4ccccc4)NCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C27H32N7O6P/c1-16-32-24(28)21-19(25(29)37)14-34(26(21)33-16)27-23(36)22(35)20(40-27)15-39-41(38,30-12-17-8-4-2-5-9-17)31-13-18-10-6-3-7-11-18/h2-11,14,20,22-23,27,35-36H,12-13,15H2,1H3,(H2,29,37)(H2,28,32,33)(H2,30,31,38)/t20-,22-,23-,27-/m1/s1
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n/an/an/an/a 6.45E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263171
PNG
(US9708359, 138)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@@H]4CCP(O)(=O)O[C@H]4[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H18N5O6P/c1-5-17-11(15)8-6(12(16)21)4-19(13(8)18-5)14-9(20)10-7(24-14)2-3-26(22,23)25-10/h4,7,9-10,14,20H,2-3H2,1H3,(H2,16,21)(H,22,23)(H2,15,17,18)/t7-,9-,10-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263180
PNG
(US9708359, 25)
Show SMILES CCOP(=O)(COC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C18H28N5O8P/c1-4-29-32(27,30-5-2)8-28-7-11-13(24)14(25)18(31-11)23-6-10(16(20)26)12-15(19)21-9(3)22-17(12)23/h6,11,13-14,18,24-25H,4-5,7-8H2,1-3H3,(H2,20,26)(H2,19,21,22)/t11-,13-,14-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263183
PNG
(US9708359, 52)
Show SMILES Cc1nc(N)c2c(cn(C[C@@H](CO)OCP(O)(O)=O)c2n1)C(N)=O
Show InChI InChI=1S/C12H18N5O6P/c1-6-15-10(13)9-8(11(14)19)3-17(12(9)16-6)2-7(4-18)23-5-24(20,21)22/h3,7,18H,2,4-5H2,1H3,(H2,14,19)(H2,13,15,16)(H2,20,21,22)/t7-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263188
PNG
(US9708359, 59)
Show SMILES C[C@H](Cn1cc(C(N)=O)c2c(N)nc(C)nc12)OCP(O)(O)=O
Show InChI InChI=1S/C12H18N5O5P/c1-6(22-5-23(19,20)21)3-17-4-8(11(14)18)9-10(13)15-7(2)16-12(9)17/h4,6H,3,5H2,1-2H3,(H2,14,18)(H2,13,15,16)(H2,19,20,21)/t6-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263194
PNG
(US9708359, 75)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N5O7P/c1-4-16-10(14)7-5(11(15)21)2-18(12(7)17-4)13-9(20)8(19)6(25-13)3-26(22,23)24/h2,6,8-9,13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263195
PNG
(US9708359, 79)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C32H56N5O9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-43-19-17-20-44-47(41,42)45-22-25-27(38)28(39)32(46-25)37-21-24(30(34)40)26-29(33)35-23(2)36-31(26)37/h21,25,27-28,32,38-39H,3-20,22H2,1-2H3,(H2,34,40)(H,41,42)(H2,33,35,36)/t25-,27-,28-,32-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263204
PNG
(US9708359, 102)
Show SMILES CC(O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C14H19N5O5/c1-4(20)10-8(21)9(22)14(24-10)19-3-6(12(16)23)7-11(15)17-5(2)18-13(7)19/h3-4,8-10,14,20-22H,1-2H3,(H2,16,23)(H2,15,17,18)/t4?,8-,9+,10+,14+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263205
PNG
(US9708359, 105)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@@](CO)(N=[N+]=[N-])[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N8O5/c1-4-17-9(14)6-5(10(15)25)2-21(11(6)18-4)12-7(23)8(24)13(3-22,26-12)19-20-16/h2,7-8,12,22-24H,3H2,1H3,(H2,15,25)(H2,14,17,18)/t7-,8+,12-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263208
PNG
(US9708359, 113)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](N)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N6O4/c1-4-17-10(15)7-5(11(16)22)2-19(12(7)18-4)13-9(21)8(14)6(3-20)23-13/h2,6,8-9,13,20-21H,3,14H2,1H3,(H2,16,22)(H2,15,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263211
PNG
(US9708359, 135)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@](F)(CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16FN5O5/c1-4-17-9(15)6-5(10(16)23)2-19(11(6)18-4)12-7(21)8(22)13(14,3-20)24-12/h2,7-8,12,20-22H,3H2,1H3,(H2,16,23)(H2,15,17,18)/t7-,8+,12-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263076
PNG
(US9708359, 5)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COC(=O)[C@@H](N)Cc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C22H26N6O6/c1-10-26-18(24)15-12(19(25)31)8-28(20(15)27-10)21-17(30)16(29)14(34-21)9-33-22(32)13(23)7-11-5-3-2-4-6-11/h2-6,8,13-14,16-17,21,29-30H,7,9,23H2,1H3,(H2,25,31)(H2,24,26,27)/t13-,14+,16+,17+,21+/m0/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263092
PNG
(US9708359, 10)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)-c1nn[nH]n1
Show InChI InChI=1S/C13H16N8O4/c1-4-15-10(14)7-5(11-17-19-20-18-11)2-21(12(7)16-4)13-9(24)8(23)6(3-22)25-13/h2,6,8-9,13,22-24H,3H2,1H3,(H2,14,15,16)(H,17,18,19,20)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 6.15E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263107
PNG
(US9708359, 32)
Show SMILES Cc1nc(N)c2c(cnc2n1)C(N)=O
Show InChI InChI=1S/C8H8N5O/c1-3-12-6(9)5-4(7(10)14)2-11-8(5)13-3/h2H,1H3,(H2,10,14)(H2,9,11,12,13)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263108
PNG
(US9708359, 33)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(O)=O
Show InChI InChI=1S/C20H22N4O6/c1-10-22-17(21)14-12(20(27)28)7-24(18(14)23-10)19-16(26)15(25)13(30-19)9-29-8-11-5-3-2-4-6-11/h2-7,13,15-16,19,25-26H,8-9H2,1H3,(H,27,28)(H2,21,22,23)/t13-,15-,16-,19-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263109
PNG
(US9708359, 34)
Show SMILES Cc1ncc2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(O)=O
Show InChI InChI=1S/C13H15N3O6/c1-5-14-2-6-7(13(20)21)3-16(11(6)15-5)12-10(19)9(18)8(4-17)22-12/h2-3,8-10,12,17-19H,4H2,1H3,(H,20,21)/t8-,9-,10-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263128
PNG
(US9708359, 63)
Show SMILES CC(C)[C@H](NC(=O)OCC1C2C=CC=CC2C2C=CC=CC12)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C33H40N6O8/c1-15(2)25(38-33(44)46-13-22-19-10-6-4-8-17(19)18-9-5-7-11-20(18)22)32(43)45-14-23-26(40)27(41)31(47-23)39-12-21(29(35)42)24-28(34)36-16(3)37-30(24)39/h4-12,15,17-20,22-23,25-27,31,40-41H,13-14H2,1-3H3,(H2,35,42)(H,38,44)(H2,34,36,37)/t17?,18?,19?,20?,22?,23-,25+,26-,27-,31-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263131
PNG
(US9708359, 68 | US9708359, 69)
Show SMILES CCOP(=O)(CO[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#N)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C17H24N5O7P/c1-4-27-30(25,28-5-2)8-26-17-13(24)12(23)16(29-17)22-7-10(6-18)11-14(19)20-9(3)21-15(11)22/h7,12-13,16-17,23-24H,4-5,8H2,1-3H3,(H2,19,20,21)/t12-,13+,16-,17+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263133
PNG
(US9708359, 70 | US9708359, 72)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](OCP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N5O8P/c1-4-16-9(14)6-5(10(15)21)2-18(11(6)17-4)12-7(19)8(20)13(26-12)25-3-27(22,23)24/h2,7-8,12-13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t7-,8+,12-,13+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263140
PNG
(US9708359, 85)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(=N)NO
Show InChI InChI=1S/C13H18N6O5/c1-4-16-11(15)7-5(10(14)18-23)2-19(12(7)17-4)13-9(22)8(21)6(3-20)24-13/h2,6,8-9,13,20-23H,3H2,1H3,(H2,14,18)(H2,15,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263141
PNG
(US9708359, 86)
Show SMILES COC(=O)C(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#N)c2c(N)nc(C)nc12)P(=O)(OC)OC
Show InChI InChI=1S/C18H24N5O9P/c1-8-21-14(20)11-9(5-19)6-23(15(11)22-8)16-13(25)12(24)10(32-16)7-31-18(17(26)28-2)33(27,29-3)30-4/h6,10,12-13,16,18,24-25H,7H2,1-4H3,(H2,20,21,22)/t10-,12-,13-,16-,18?/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263143
PNG
(US9708359, 91)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=N
Show InChI InChI=1S/C13H18N6O4/c1-4-17-11(16)7-5(10(14)15)2-19(12(7)18-4)13-9(22)8(21)6(3-20)23-13/h2,6,8-9,13,20-22H,3H2,1H3,(H3,14,15)(H2,16,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263147
PNG
(US9708359, 98)
Show SMILES Cc1nc(Cl)c2ccn(C[C@H](O)CO)c2n1
Show InChI InChI=1S/C10H12ClN3O2/c1-6-12-9(11)8-2-3-14(10(8)13-6)4-7(16)5-15/h2-3,7,15-16H,4-5H2,1H3/t7-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263157
PNG
(US9708359, 117)
Show SMILES Cc1nc(Cl)c2c(cn([C@@H]3O[C@H](O)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C12H11ClN4O4/c1-4-15-9(13)6-5(2-14)3-17(10(6)16-4)11-7(18)8(19)12(20)21-11/h3,7-8,11-12,18-20H,1H3/t7-,8+,11-,12+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263166
PNG
(US9708359, 130)
Show SMILES CCCCCCCCCCCCCCCCOCCCC(=O)Nc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C33H55N5O7/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-44-20-17-18-26(40)37-31-27-24(30(34)43)21-38(32(27)36-23(2)35-31)33-29(42)28(41)25(22-39)45-33/h21,25,28-29,33,39,41-42H,3-20,22H2,1-2H3,(H2,34,43)(H,35,36,37,40)/t25-,28-,29-,33-/m1/s1
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n/an/an/an/a 4.27E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263176
PNG
(US9708359, 13)
Show SMILES CCc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H19N5O5/c1-2-7-17-11(15)8-5(12(16)23)3-19(13(8)18-7)14-10(22)9(21)6(4-20)24-14/h3,6,9-10,14,20-22H,2,4H2,1H3,(H2,16,23)(H2,15,17,18)/t6-,9-,10-,14-/m1/s1
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n/an/an/an/a>2.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263177
PNG
(US9708359, 15)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C18H19N5O5/c19-14-11-9(15(20)27)6-23(18-13(26)12(25)10(7-24)28-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,27)(H2,19,21,22)/t10-,12-,13-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263181
PNG
(US9708359, 26 | US9708359, 80)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)C(F)(F)F
Show InChI InChI=1S/C13H14F3N5O5/c14-13(15,16)12-19-8(17)5-3(9(18)25)1-21(10(5)20-12)11-7(24)6(23)4(2-22)26-11/h1,4,6-7,11,22-24H,2H2,(H2,18,25)(H2,17,19,20)/t4-,6-,7-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263182
PNG
(US9708359, 40)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)C3(F)F)c2n1)C(N)=O
Show InChI InChI=1S/C13H15F2N5O4/c1-4-18-9(16)7-5(10(17)23)2-20(11(7)19-4)12-13(14,15)8(22)6(3-21)24-12/h2,6,8,12,21-22H,3H2,1H3,(H2,17,23)(H2,16,18,19)/t6-,8-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263185
PNG
(US9708359, 56)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](CO)Cn1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C31H56N5O7P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-41-19-17-20-43-44(39,40)24-42-26(23-37)21-36-22-27(30(33)38)28-29(32)34-25(2)35-31(28)36/h22,26,37H,3-21,23-24H2,1-2H3,(H2,33,38)(H,39,40)(H2,32,34,35)/t26-/m0/s1
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n/an/an/an/a 7.53E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263191
PNG
(US9708359, 67)
Show SMILES CCOP(=O)(COC[C@H]1O[C@H](C=C1)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C18H26N5O6P/c1-4-27-30(25,28-5-2)10-26-9-12-6-7-14(29-12)23-8-13(17(20)24)15-16(19)21-11(3)22-18(15)23/h6-8,12,14H,4-5,9-10H2,1-3H3,(H2,20,24)(H2,19,21,22)/t12-,14+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263197
PNG
(US9708359, 87)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@@]3(C)O)c2n1)C(N)=O
Show InChI InChI=1S/C14H19N5O5/c1-5-17-10(15)8-6(11(16)22)3-19(12(8)18-5)13-14(2,23)9(21)7(4-20)24-13/h3,7,9,13,20-21,23H,4H2,1-2H3,(H2,16,22)(H2,15,17,18)/t7-,9-,13-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263203
PNG
(US9708359, 101)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16FN5O4/c1-4-17-10(15)7-5(11(16)22)2-19(12(7)18-4)13-9(21)8(14)6(3-20)23-13/h2,6,8-9,13,20-21H,3H2,1H3,(H2,16,22)(H2,15,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263212
PNG
(US9708359, 127)
Show SMILES CN(C)\C=N\c1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C16H22N6O5/c1-7-19-14(18-6-21(2)3)10-8(13(17)26)4-22(15(10)20-7)16-12(25)11(24)9(5-23)27-16/h4,6,9,11-12,16,23-25H,5H2,1-3H3,(H2,17,26)/b18-6+/t9-,11-,12-,16-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263079
PNG
(US9708359, 77)
Show SMILES CC(C)C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H28N6O6/c1-7(2)4-10(20)19(29)30-6-11-13(26)14(27)18(31-11)25-5-9(16(22)28)12-15(21)23-8(3)24-17(12)25/h5,7,10-11,13-14,18,26-27H,4,6,20H2,1-3H3,(H2,22,28)(H2,21,23,24)/t10-,11+,13+,14+,18+/m0/s1
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n/an/an/an/a 4.40E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263082
PNG
(US9708359, 111)
Show SMILES COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C23H29N6O9P/c1-11(23(33)35-3)28-39(34,38-13-7-5-4-6-8-13)36-10-15-17(30)18(31)22(37-15)29-9-14(20(25)32)16-19(24)26-12(2)27-21(16)29/h4-9,11,15,17-18,22,30-31H,10H2,1-3H3,(H2,25,32)(H,28,34)(H2,24,26,27)/t11-,15+,17+,18+,22+,39?/m0/s1
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n/an/an/an/a 2.10E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263086
PNG
(US9708359, 139)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C41H65N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-24-53-25-21-26-54-41(51)29(2)46-58(52,57-31-22-18-17-19-23-31)55-28-33-35(48)36(49)40(56-33)47-27-32(38(43)50)34-37(42)44-30(3)45-39(34)47/h17-19,22-23,27,29,33,35-36,40,48-49H,4-16,20-21,24-26,28H2,1-3H3,(H2,43,50)(H,46,52)(H2,42,44,45)/t29-,33+,35+,36+,40+,58?/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263093
PNG
(US9708359, 11)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H15N5O4/c1-5-16-11(15)8-6(2-14)3-18(12(8)17-5)13-10(21)9(20)7(4-19)22-13/h3,7,9-10,13,19-21H,4H2,1H3,(H2,15,16,17)/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.21E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263096
PNG
(US9708359, 17)
Show SMILES Nc1nc(nc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)-c1ccccc1
Show InChI InChI=1S/C18H17N5O4/c19-6-10-7-23(18-14(26)13(25)11(8-24)27-18)17-12(10)15(20)21-16(22-17)9-4-2-1-3-5-9/h1-5,7,11,13-14,18,24-26H,8H2,(H2,20,21,22)/t11-,13-,14-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263105
PNG
(US9708359, 30)
Show SMILES COc1nc(C)nc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H16N4O5/c1-6-16-12-9(13(17-6)22-2)7(3-15)4-18(12)14-11(21)10(20)8(5-19)23-14/h4,8,10-11,14,19-21H,5H2,1-2H3/t8-,10-,11-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263111
PNG
(US9708359, 36)
Show SMILES CNc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H19N5O5/c1-5-17-12(16-2)8-6(11(15)23)3-19(13(8)18-5)14-10(22)9(21)7(4-20)24-14/h3,7,9-10,14,20-22H,4H2,1-2H3,(H2,15,23)(H,16,17,18)/t7-,9-,10-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263115
PNG
(US9708359, 41)
Show SMILES CN(C)C(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12
Show InChI InChI=1S/C15H21N5O5/c1-6-17-12(16)9-7(14(24)19(2)3)4-20(13(9)18-6)15-11(23)10(22)8(5-21)25-15/h4,8,10-11,15,21-23H,5H2,1-3H3,(H2,16,17,18)/t8-,10-,11-,15-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263124
PNG
(US9708359, 50)
Show SMILES Cc1nc(N)c2c(cn(C[C@H](O)CO)c2n1)C(N)=O
Show InChI InChI=1S/C11H15N5O3/c1-5-14-9(12)8-7(10(13)19)3-16(11(8)15-5)2-6(18)4-17/h3,6,17-18H,2,4H2,1H3,(H2,13,19)(H2,12,14,15)/t6-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263142
PNG
(US9708359, 88)
Show SMILES COC(=O)C(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)P(=O)(OC)OC
Show InChI InChI=1S/C18H26N5O10P/c1-7-21-13(19)10-8(14(20)26)5-23(15(10)22-7)16-12(25)11(24)9(33-16)6-32-18(17(27)29-2)34(28,30-3)31-4/h5,9,11-12,16,18,24-25H,6H2,1-4H3,(H2,20,26)(H2,19,21,22)/t9-,11-,12-,16-,18?/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263154
PNG
(US9708359, 114 | US9708359, 115)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](O)C=C3)c2n1)C#N
Show InChI InChI=1S/C12H11N5O2/c1-6-15-11(14)10-7(4-13)5-17(12(10)16-6)8-2-3-9(18)19-8/h2-3,5,8-9,18H,1H3,(H2,14,15,16)/t8-,9+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263172
PNG
(US9708359, 140)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(=O)(N[C@@H](C)C(=O)OC(C)C)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C38H67N6O10P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-50-22-20-23-51-55(49,43-27(4)38(48)53-26(2)3)52-25-30-32(45)33(46)37(54-30)44-24-29(35(40)47)31-34(39)41-28(5)42-36(31)44/h24,26-27,30,32-33,37,45-46H,6-23,25H2,1-5H3,(H2,40,47)(H,43,49)(H2,39,41,42)/t27-,30+,32+,33+,37+,55?/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263186
PNG
(US9708359, 57)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3N=[N+]=[N-])c2n1)C(N)=O
Show InChI InChI=1S/C13H16N8O4/c1-4-17-10(14)7-5(11(15)24)2-21(12(7)18-4)13-8(19-20-16)9(23)6(3-22)25-13/h2,6,8-9,13,22-23H,3H2,1H3,(H2,15,24)(H2,14,17,18)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263193
PNG
(US9708359, 74)
Show SMILES CCOP(=O)(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C17H26N5O7P/c1-4-27-30(26,28-5-2)7-10-12(23)13(24)17(29-10)22-6-9(15(19)25)11-14(18)20-8(3)21-16(11)22/h6,10,12-13,17,23-24H,4-5,7H2,1-3H3,(H2,19,25)(H2,18,20,21)/t10-,12-,13-,17-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263198
PNG
(US9708359, 89)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)C#N
Show InChI InChI=1S/C13H14N6O5/c14-1-6-17-10(15)7-4(11(16)23)2-19(12(7)18-6)13-9(22)8(21)5(3-20)24-13/h2,5,8-9,13,20-22H,3H2,(H2,16,23)(H2,15,17,18)/t5-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263200
PNG
(US9708359, 92)
Show SMILES Cc1nc(N)c2c(cn([C@H]3C[C@H](O)[C@@H](CO)O3)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O4/c1-5-16-11(14)10-6(12(15)21)3-18(13(10)17-5)9-2-7(20)8(4-19)22-9/h3,7-9,19-20H,2,4H2,1H3,(H2,15,21)(H2,14,16,17)/t7-,8+,9+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%