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Patent code US9713606

Compile Data Set for Download or QSAR

Found 584 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150482
PNG
(US8987249, 156 | US9713606, 156)
Show SMILES CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H26FN3O3/c1-26(2)21-11-14(6-8-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150329
PNG
(US8987249, 3 | US9713606, 3)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150481
PNG
(US8987249, 155 | US9713606, 155)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H32FN5O3S/c1-32-10-12-33(13-11-32)37(35,36)24-8-5-18(6-9-24)19-2-3-20(25(28)16-19)14-23(17-29)31-27(34)26-21-4-7-22(15-21)30-26/h2-3,5-6,8-9,16,21-23,26,30H,4,7,10-15H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150648
PNG
(US8987249, 322 | US9713606, 322)
Show SMILES Fc1cc2c3ccccc3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N
Show InChI InChI=1S/C23H21FN4O2/c24-19-10-17-16-3-1-2-4-20(16)28-22(29)18(17)9-13(19)8-15(11-25)27-23(30)21-12-5-6-14(7-12)26-21/h1-4,9-10,12,14-15,21,26H,5-8H2,(H,27,30)(H,28,29)/t12-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150551
PNG
(US8987249, 225 | US9713606, 225)
Show SMILES CN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H30FN5O2S/c1-31-6-8-32(9-7-31)26(34)23-13-19(15-35-23)16-2-3-17(22(27)12-16)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150649
PNG
(US8987249, 323 | US9713606, 323)
Show SMILES Fc1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-16-17-9-19(25)12(7-18(17)22(30)29-20(16)8-13)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150552
PNG
(US8987249, 226 | US9713606, 226)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCn2nccc2C1
Show InChI InChI=1S/C27H27FN6O2S/c28-23-11-16(19-12-24(37-15-19)27(36)33-7-8-34-22(14-33)5-6-30-34)1-2-17(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150618
PNG
(US8987249, 292 | US9713606, 292)
Show SMILES Fc1cc2c3ccc(cc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N
Show InChI InChI=1S/C24H20FN5O2/c25-20-9-18-17-4-1-12(10-26)5-21(17)30-23(31)19(18)8-14(20)7-16(11-27)29-24(32)22-13-2-3-15(6-13)28-22/h1,4-5,8-9,13,15-16,22,28H,2-3,6-7H2,(H,29,32)(H,30,31)/t13-,15+,16?,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150483
PNG
(US8987249, 157 | US9713606, 157)
Show SMILES NC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H21FN4O2S/c22-17-7-11(14-8-18(20(24)27)29-10-14)1-2-12(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150672
PNG
(US8987249, 346 | US9713606, 346)
Show SMILES CN1CCC(CC1)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C30H34FN5O2/c1-35-10-8-25(9-11-35)36-27-15-19(3-5-21(27)16-28(36)37)18-2-4-20(26(31)14-18)12-24(17-32)34-30(38)29-22-6-7-23(13-22)33-29/h2-5,14-15,22-25,29,33H,6-13,16H2,1H3,(H,34,38)/t22-,23+,24-,29-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150604
PNG
(US8987249, 278 | US9713606, 278)
Show SMILES CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-14-18(4-6-20(25)15-26(34)35)17-3-5-19(24(29)13-17)11-23(16-30)32-28(36)27-21-7-8-22(12-21)31-27/h3-6,13-14,21-23,27,31H,7-12,15H2,1-2H3,(H,32,36)/t21-,22+,23-,27-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150553
PNG
(US8987249, 227 | US9713606, 227)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H34FN5O2S/c1-17(2)33-7-9-34(10-8-33)28(36)25-14-21(16-37-25)18-3-4-19(24(29)13-18)11-23(15-30)32-27(35)26-20-5-6-22(12-20)31-26/h3-4,13-14,16-17,20,22-23,26,31H,5-12H2,1-2H3,(H,32,35)/t20-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150650
PNG
(US8987249, 324 | US9713606, 324)
Show SMILES Fc1ccc2c3cc(F)c(C[C@H](NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F
Show InChI InChI=1S/C23H19F3N4O2/c24-17-4-3-14-15-8-18(25)11(7-16(15)22(31)30-21(14)19(17)26)6-13(9-27)29-23(32)20-10-1-2-12(5-10)28-20/h3-4,7-8,10,12-13,20,28H,1-2,5-6H2,(H,29,32)(H,30,31)/t10-,12+,13-,20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150550
PNG
(US8987249, 224 | US9713606, 224)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H32FN5O3S/c1-32-9-11-33(12-10-32)37(35,36)24-4-2-3-18(15-24)19-5-6-20(25(28)16-19)13-23(17-29)31-27(34)26-21-7-8-22(14-21)30-26/h2-6,15-16,21-23,26,30H,7-14H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150665
PNG
(US8987249, 339 | US9713606, 339)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H31F2N5O3S/c1-33-8-10-34(11-9-33)38(36,37)25-15-18(5-7-23(25)28)17-2-3-19(24(29)14-17)12-22(16-30)32-27(35)26-20-4-6-21(13-20)31-26/h2-3,5,7,14-15,20-22,26,31H,4,6,8-13H2,1H3,(H,32,35)/t20-,21+,22-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150668
PNG
(US8987249, 342 | US9713606, 342)
Show SMILES CN(C)CCn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-15-19(6-8-23(31)32)16-3-4-17(22(26)13-16)11-21(14-27)29-25(33)24-18-5-7-20(12-18)28-24/h3-4,6,8,13,15,18,20-21,24,28H,5,7,9-12H2,1-2H3,(H,29,33)/t18-,20+,21-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150619
PNG
(US8987249, 293 | US9713606, 293)
Show SMILES Fc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-16-17-9-19(25)12(7-18(17)22(30)29-20(16)8-13)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15?,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150651
PNG
(US8987249, 325 | US9713606, 325)
Show SMILES Fc1cc2c3cc(cc(F)c3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N
Show InChI InChI=1S/C24H19F2N5O2/c25-19-8-16-17-3-11(9-27)4-20(26)22(17)31-23(32)18(16)7-13(19)6-15(10-28)30-24(33)21-12-1-2-14(5-12)29-21/h3-4,7-8,12,14-15,21,29H,1-2,5-6H2,(H,30,33)(H,31,32)/t12-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150330
PNG
(US8987249, 4 | US9713606, 4)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150484
PNG
(US8987249, 158 | US9713606, 158)
Show SMILES COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H29FN4O3/c1-35-9-8-32-24-13-17(3-5-19(24)14-25(32)33)16-2-4-18(23(28)12-16)10-22(15-29)31-27(34)26-20-6-7-21(11-20)30-26/h2-5,12-13,20-22,26,30H,6-11,14H2,1H3,(H,31,34)/t20-,21+,22-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150336
PNG
(US8987249, 10 | US9713606, 10)
Show SMILES CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H23FN4O3/c1-30-21-11-14(5-7-19(21)23(31)25(30)33)13-2-3-15(20(26)10-13)8-18(12-27)29-24(32)22-16-4-6-17(9-16)28-22/h2-3,5,7,10-11,16-18,22,28H,4,6,8-9H2,1H3,(H,29,32)/t16-,17+,18-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150562
PNG
(US8987249, 236 | US9713606, 236)
Show SMILES NC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H21FN4O2S/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150554
PNG
(US8987249, 228 | US9713606, 228)
Show SMILES COCCN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H34FN5O3S/c1-37-11-10-33-6-8-34(9-7-33)28(36)25-15-21(17-38-25)18-2-3-19(24(29)14-18)12-23(16-30)32-27(35)26-20-4-5-22(13-20)31-26/h2-3,14-15,17,20,22-23,26,31H,4-13H2,1H3,(H,32,35)/t20-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150620
PNG
(US8987249, 294 | US9713606, 294)
Show SMILES Fc1cc2c3ccccc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N
Show InChI InChI=1S/C23H21FN4O2/c24-19-10-17-16-3-1-2-4-20(16)28-22(29)18(17)9-13(19)8-15(11-25)27-23(30)21-12-5-6-14(7-12)26-21/h1-4,9-10,12,14-15,21,26H,5-8H2,(H,27,30)(H,28,29)/t12-,14+,15?,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150485
PNG
(US8987249, 159 | US9713606, 159)
Show SMILES CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H23FN4O3S/c1-33(31,32)22-7-5-14(8-18(22)12-26)15-2-3-16(21(25)11-15)9-20(13-27)29-24(30)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150337
PNG
(US8987249, 11 | US9713606, 11)
Show SMILES Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19?,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150555
PNG
(US8987249, 229 | US9713606, 229)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C28H32FN5O2S/c29-24-13-17(20-14-25(37-16-20)28(36)34-9-7-33(8-10-34)23-5-6-23)1-2-18(24)11-22(15-30)32-27(35)26-19-3-4-21(12-19)31-26/h1-2,13-14,16,19,21-23,26,31H,3-12H2,(H,32,35)/t19-,21+,22-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150486
PNG
(US8987249, 160 | US9713606, 160)
Show SMILES Cc1nn(C)cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H24FN5O/c1-12-18(11-27(2)26-12)13-3-4-14(19(22)9-13)7-17(10-23)25-21(28)20-15-5-6-16(8-15)24-20/h3-4,9,11,15-17,20,24H,5-8H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150556
PNG
(US8987249, 230 | US9713606, 230)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H27FN4O3S/c26-21-11-15(18-12-22(34-14-18)25(32)30-5-7-33-8-6-30)1-2-16(21)9-20(13-27)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11-12,14,17,19-20,23,28H,3-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM263947
PNG
(US9713606, 340)
Show SMILES CN1CCCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)C2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H34FN5O3S/c1-33-11-2-12-34(14-13-33)38(36,37)25-9-6-19(7-10-25)20-3-4-21(26(29)17-20)15-24(18-30)32-28(35)27-22-5-8-23(16-22)31-27/h3-4,6-7,9-10,17,22-24,27,31H,2,5,8,11-16H2,1H3,(H,32,35)/t22-,23+,24-,27?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150339
PNG
(US8987249, 13 | US9713606, 13)
Show SMILES COC(=O)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H24FN5O3/c1-31-20(29)12-28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150652
PNG
(US8987249, 326 | US9713606, 326)
Show SMILES Cn1c2ccccc2c2cc(F)c(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O
Show InChI InChI=1S/C24H23FN4O2/c1-29-21-5-3-2-4-17(21)18-11-20(25)14(10-19(18)24(29)31)9-16(12-26)28-23(30)22-13-6-7-15(8-13)27-22/h2-5,10-11,13,15-16,22,27H,6-9H2,1H3,(H,28,30)/t13-,15+,16-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150333
PNG
(US8987249, 7 | US9713606, 7)
Show SMILES CC(=O)n1nc(cc1C)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H24FN5O2/c1-12-7-20(27-28(12)13(2)29)15-4-3-14(19(23)10-15)8-18(11-24)26-22(30)21-16-5-6-17(9-16)25-21/h3-4,7,10,16-18,21,25H,5-6,8-9H2,1-2H3,(H,26,30)/t16-,17+,18?,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150338
PNG
(US8987249, 12 | US9713606, 12)
Show SMILES CS(=O)(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-7-5-14(11-20(21)25)13-2-3-15(19(24)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150487
PNG
(US8987249, 161 | US9713606, 161)
Show SMILES CNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H23FN4O2S/c1-25-21(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)27-22(29)20-14-4-5-16(7-14)26-20/h2-3,8-9,11,14,16-17,20,26H,4-7H2,1H3,(H,25,28)(H,27,29)/t14-,16+,17-,20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150340
PNG
(US8987249, 14 | US9713606, 14)
Show SMILES CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150580
PNG
(US8987249, 254 | US9713606, 254)
Show SMILES Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H23FN4O2/c1-27-12-16(5-7-20(27)28)13-2-3-14(19(23)10-13)8-18(11-24)26-22(29)21-15-4-6-17(9-15)25-21/h2-3,5,7,10,12,15,17-18,21,25H,4,6,8-9H2,1H3,(H,26,29)/t15-,17+,18-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150341
PNG
(US8987249, 15 | US9713606, 15)
Show SMILES CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20?,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150488
PNG
(US8987249, 162 | US9713606, 162)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C#N
Show InChI InChI=1S/C21H19FN4O2/c22-18-9-13(19-6-5-17(11-24)28-19)2-1-12(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150328
PNG
(US8987249, 2 | US9713606, 2)
Show SMILES CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150621
PNG
(US8987249, 295 | US9713606, 295)
Show SMILES Fc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)c(F)cc3c2c1
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-20-17(8-13)16-9-19(25)12(7-18(16)22(30)29-20)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15?,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150478
PNG
(US8987249, 152 | US9713606, 152)
Show SMILES CS(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-11-14(5-7-19(21)24)13-2-3-15(20(25)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150489
PNG
(US8987249, 163 | US9713606, 163)
Show SMILES Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C20H22FN5O/c1-26-11-15(10-23-26)12-2-3-13(18(21)8-12)6-17(9-22)25-20(27)19-14-4-5-16(7-14)24-19/h2-3,8,10-11,14,16-17,19,24H,4-7H2,1H3,(H,25,27)/t14-,16+,17-,19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150558
PNG
(US8987249, 232 | US9713606, 232)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C27H29F4N5O2S/c28-22-11-16(1-2-17(22)9-21(13-32)34-25(37)24-18-3-4-20(10-18)33-24)19-12-23(39-14-19)26(38)36-7-5-35(6-8-36)15-27(29,30)31/h1-2,11-12,14,18,20-21,24,33H,3-10,15H2,(H,34,37)/t18-,20+,21-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150557
PNG
(US8987249, 231 | US9713606, 231)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H30FN5O3S/c1-16(34)32-6-8-33(9-7-32)27(36)24-13-20(15-37-24)17-2-3-18(23(28)12-17)10-22(14-29)31-26(35)25-19-4-5-21(11-19)30-25/h2-3,12-13,15,19,21-22,25,30H,4-11H2,1H3,(H,31,35)/t19-,21+,22-,25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150559
PNG
(US8987249, 233 | US9713606, 233)
Show SMILES CN1CCN(CC1=O)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H28FN5O3S/c1-31-6-7-32(13-23(31)33)26(35)22-11-18(14-36-22)15-2-3-16(21(27)10-15)8-20(12-28)30-25(34)24-17-4-5-19(9-17)29-24/h2-3,10-11,14,17,19-20,24,29H,4-9,13H2,1H3,(H,30,34)/t17-,19+,20-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150548
PNG
(US8987249, 222 | US9713606, 222)
Show SMILES CS(=O)(=NC#N)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-4-2-3-15(11-21)16-5-6-17(22(25)12-16)9-20(13-26)30-24(31)23-18-7-8-19(10-18)29-23/h2-6,11-12,18-20,23,29H,7-10H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150614
PNG
(US8987249, 288 | US9713606, 288)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H27FN4O4/c26-20-13-16(21-5-6-22(34-21)25(32)30-7-9-33-10-8-30)2-1-15(20)11-19(14-27)29-24(31)23-17-3-4-18(12-17)28-23/h1-2,5-6,13,17-19,23,28H,3-4,7-12H2,(H,29,31)/t17-,18+,19-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150490
PNG
(US8987249, 164 | US9713606, 164)
Show SMILES CCCNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H27FN4O2S/c1-2-7-27-23(30)21-11-17(13-32-21)14-3-4-15(20(25)10-14)8-19(12-26)29-24(31)22-16-5-6-18(9-16)28-22/h3-4,10-11,13,16,18-19,22,28H,2,5-9H2,1H3,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150615
PNG
(US8987249, 289 | US9713606, 289)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H30FN5O3/c1-31-8-10-32(11-9-31)26(34)23-7-6-22(35-23)17-3-2-16(21(27)14-17)12-20(15-28)30-25(33)24-18-4-5-19(13-18)29-24/h2-3,6-7,14,18-20,24,29H,4-5,8-13H2,1H3,(H,30,33)/t18-,19+,20-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%