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Patent code US9714232

Compile Data Set for Download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264121
PNG
(3-(3-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H27N5O2/c30-19-21-3-8-27-26(18-21)22(20-31-27)2-1-11-32-13-15-33(16-14-32)23-4-6-24(7-5-23)34-12-9-28-25(29(34)35)10-17-36-28/h3-10,12,17-18,20,31H,1-2,11,13-16H2
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0.100n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264120
PNG
(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H29N5O2/c31-20-22-4-9-28-27(19-22)23(21-32-28)3-1-2-12-33-14-16-34(17-15-33)24-5-7-25(8-6-24)35-13-10-29-26(30(35)36)11-18-37-29/h4-11,13,18-19,21,32H,1-3,12,14-17H2
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0.140n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264112
PNG
(3-(4-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H27F2N5O/c29-22-16-26(30)28(36)35(19-22)24-7-5-23(6-8-24)34-13-11-33(12-14-34)10-2-1-3-21-18-32-27-9-4-20(17-31)15-25(21)27/h4-9,15-16,18-19,32H,1-3,10-14H2
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0.180n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264097
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C27H29FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h2,4,6-12,14,19-20,29H,1,3,5,13,15-18H2
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0.190n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264096
PNG
(3-(4-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H29N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h2,4,6-12,14,19,21,30H,1,3,5,13,15-18H2
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0.230n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264113
PNG
(3-(3-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H25F2N5O/c28-21-15-25(29)27(35)34(18-21)23-6-4-22(5-7-23)33-12-10-32(11-13-33)9-1-2-20-17-31-26-8-3-19(16-30)14-24(20)26/h3-8,14-15,17-18,31H,1-2,9-13H2
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0.310n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264104
PNG
(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O/c1-22-11-13-34(29(35)18-22)26-8-6-25(7-9-26)33-16-14-32(15-17-33)12-3-2-4-24-21-31-28-10-5-23(20-30)19-27(24)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
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0.480n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264118
PNG
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C31H30N6O/c32-21-23-6-11-29-28(20-23)24(22-34-29)4-1-2-14-35-16-18-36(19-17-35)25-7-9-26(10-8-25)37-15-12-30-27(31(37)38)5-3-13-33-30/h3,5-13,15,20,22,34H,1-2,4,14,16-19H2
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0.5n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264109
PNG
(3-(3-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O2/c1-35-25-10-12-33(28(34)18-25)24-7-5-23(6-8-24)32-15-13-31(14-16-32)11-2-3-22-20-30-27-9-4-21(19-29)17-26(22)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
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0.610n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264122
PNG
(3-(4-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H28N6O/c28-18-21-4-9-26-25(17-21)22(19-30-26)3-1-2-11-31-13-15-32(16-14-31)23-5-7-24(8-6-23)33-12-10-29-20-27(33)34/h4-10,12,17,19-20,30H,1-3,11,13-16H2
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0.800n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264099
PNG
(1-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C26H27FN4O/c27-21-6-11-25-24(18-21)20(19-28-25)4-3-12-29-14-16-30(17-15-29)22-7-9-23(10-8-22)31-13-2-1-5-26(31)32/h1-2,5-11,13,18-19,28H,3-4,12,14-17H2
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0.870n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264105
PNG
(3-(3-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O/c1-21-10-12-33(28(34)17-21)25-7-5-24(6-8-25)32-15-13-31(14-16-32)11-2-3-23-20-30-27-9-4-22(19-29)18-26(23)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
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0.890n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264108
PNG
(3-(4-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O2/c1-36-26-11-13-34(29(35)19-26)25-8-6-24(7-9-25)33-16-14-32(15-17-33)12-3-2-4-23-21-31-28-10-5-22(20-30)18-27(23)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
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1.20n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264091
PNG
(3-(3-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h6-11,18,20,29H,1-5,12-17H2
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1.20n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264098
PNG
(3-(3-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H27N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h1-2,5-11,13,18,20,29H,3-4,12,14-17H2
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1.20n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264124
PNG
(3-(4-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H32N6O/c28-19-21-5-10-26-25(18-21)22(20-30-26)4-1-2-12-31-14-16-32(17-15-31)23-6-8-24(9-7-23)33-13-3-11-29-27(33)34/h5-10,18,20,30H,1-4,11-17H2,(H,29,34)
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1.30n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264115
PNG
(3-(5-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H29F2N5O/c30-23-17-27(31)29(37)36(20-23)25-8-6-24(7-9-25)35-14-12-34(13-15-35)11-3-1-2-4-22-19-33-28-10-5-21(18-32)16-26(22)28/h5-10,16-17,19-20,33H,1-4,11-15H2
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1.5n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264119
PNG
(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H28N6O/c31-20-22-5-10-28-27(19-22)23(21-33-28)3-2-13-34-15-17-35(18-16-34)24-6-8-25(9-7-24)36-14-11-29-26(30(36)37)4-1-12-32-29/h1,4-12,14,19,21,33H,2-3,13,15-18H2
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1.70n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264011
PNG
(3-(4-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H33N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h7-12,19,21,30H,1-6,13-18H2
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1.90n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264125
PNG
(3-(3-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H30N6O/c27-18-20-4-9-25-24(17-20)21(19-29-25)3-1-11-30-13-15-31(16-14-30)22-5-7-23(8-6-22)32-12-2-10-28-26(32)33/h4-9,17,19,29H,1-3,10-16H2,(H,28,33)
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1.90n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264093
PNG
(3-(4-(4-(4-(3-oxomorpholino)phenyl)piperazin-1-yl)...)
Show SMILES O=C1COCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O2/c28-18-21-4-9-26-25(17-21)22(19-29-26)3-1-2-10-30-11-13-31(14-12-30)23-5-7-24(8-6-23)32-15-16-34-20-27(32)33/h4-9,17,19,29H,1-3,10-16,20H2
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2.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM263988
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)N3CCCCC3=O)c2c1
Show InChI InChI=1S/C27H33FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h7-12,19-20,29H,1-6,13-18H2
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2.5n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264123
PNG
(3-(3-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H26N6O/c27-17-20-3-8-25-24(16-20)21(18-29-25)2-1-10-30-12-14-31(15-13-30)22-4-6-23(7-5-22)32-11-9-28-19-26(32)33/h3-9,11,16,18-19,29H,1-2,10,12-15H2
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3n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264092
PNG
(4-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)N3CCOCC3=O)c2c1
Show InChI InChI=1S/C26H31FN4O2/c27-21-4-9-25-24(17-21)20(18-28-25)3-1-2-10-29-11-13-30(14-12-29)22-5-7-23(8-6-22)31-15-16-33-19-26(31)32/h4-9,17-18,28H,1-3,10-16,19H2
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3.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264024
PNG
(1-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)N3CCCCC3=O)c2c1
Show InChI InChI=1S/C26H31FN4O/c27-21-6-11-25-24(18-21)20(19-28-25)4-3-12-29-14-16-30(17-15-29)22-7-9-23(10-8-22)31-13-2-1-5-26(31)32/h6-11,18-19,28H,1-5,12-17H2
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3.20n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264095
PNG
(3-(3-(4-(4-(3-oxomorpholino)phenyl)piperazin-1-yl)...)
Show SMILES O=C1COCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H29N5O2/c27-17-20-3-8-25-24(16-20)21(18-28-25)2-1-9-29-10-12-30(13-11-29)22-4-6-23(7-5-22)31-14-15-33-19-26(31)32/h3-8,16,18,28H,1-2,9-15,19H2
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3.20n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264117
PNG
(3-(3-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Show SMILES O=c1n(ccc2ccccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C31H29N5O/c32-21-23-7-12-30-29(20-23)25(22-33-30)5-3-14-34-16-18-35(19-17-34)26-8-10-27(11-9-26)36-15-13-24-4-1-2-6-28(24)31(36)37/h1-2,4,6-13,15,20,22,33H,3,5,14,16-19H2
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3.60n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264101
PNG
(3-(5-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H31N5O/c30-21-23-8-13-28-27(20-23)24(22-31-28)6-2-1-4-14-32-16-18-33(19-17-32)25-9-11-26(12-10-25)34-15-5-3-7-29(34)35/h3,5,7-13,15,20,22,31H,1-2,4,6,14,16-19H2
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4.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264107
PNG
(3-(5-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C30H33N5O/c1-23-12-14-35(30(36)19-23)27-9-7-26(8-10-27)34-17-15-33(16-18-34)13-4-2-3-5-25-22-32-29-11-6-24(21-31)20-28(25)29/h6-12,14,19-20,22,32H,2-5,13,15-18H2,1H3
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4.70n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264094
PNG
(4-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)N3CCOCC3=O)c2c1
Show InChI InChI=1S/C25H29FN4O2/c26-20-3-8-24-23(16-20)19(17-27-24)2-1-9-28-10-12-29(13-11-28)21-4-6-22(7-5-21)30-14-15-32-18-25(30)31/h3-8,16-17,27H,1-2,9-15,18H2
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6.40n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264111
PNG
(3-(5-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C30H33N5O2/c1-37-27-12-14-35(30(36)20-27)26-9-7-25(8-10-26)34-17-15-33(16-18-34)13-4-2-3-5-24-22-32-29-11-6-23(21-31)19-28(24)29/h6-12,14,19-20,22,32H,2-5,13,15-18H2,1H3
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12n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264106
PNG
(3-(2-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C27H27N5O/c1-20-8-11-32(27(33)16-20)24-5-3-23(4-6-24)31-14-12-30(13-15-31)10-9-22-19-29-26-7-2-21(18-28)17-25(22)26/h2-8,11,16-17,19,29H,9-10,12-15H2,1H3
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33n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264100
PNG
(3-(2-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H25N5O/c27-18-20-4-9-25-24(17-20)21(19-28-25)10-12-29-13-15-30(16-14-29)22-5-7-23(8-6-22)31-11-2-1-3-26(31)32/h1-9,11,17,19,28H,10,12-16H2
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54n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264114
PNG
(3-(2-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H23F2N5O/c27-20-14-24(28)26(34)33(17-20)22-4-2-21(3-5-22)32-11-9-31(10-12-32)8-7-19-16-30-25-6-1-18(15-29)13-23(19)25/h1-6,13-14,16-17,30H,7-12H2
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68n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264118
PNG
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C31H30N6O/c32-21-23-6-11-29-28(20-23)24(22-34-29)4-1-2-14-35-16-18-36(19-17-35)25-7-9-26(10-8-25)37-15-12-30-27(31(37)38)5-3-13-33-30/h3,5-13,15,20,22,34H,1-2,4,14,16-19H2
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n/an/a 0.230n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264120
PNG
(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H29N5O2/c31-20-22-4-9-28-27(19-22)23(21-32-28)3-1-2-12-33-14-16-34(17-15-33)24-5-7-25(8-6-24)35-13-10-29-26(30(35)36)11-18-37-29/h4-11,13,18-19,21,32H,1-3,12,14-17H2
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n/an/a 0.530n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264122
PNG
(3-(4-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H28N6O/c28-18-21-4-9-26-25(17-21)22(19-30-26)3-1-2-11-31-13-15-32(16-14-31)23-5-7-24(8-6-23)33-12-10-29-20-27(33)34/h4-10,12,17,19-20,30H,1-3,11,13-16H2
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n/an/a 0.800n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264119
PNG
(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H28N6O/c31-20-22-5-10-28-27(19-22)23(21-33-28)3-2-13-34-15-17-35(18-16-34)24-6-8-25(9-7-24)36-14-11-29-26(30(36)37)4-1-12-32-29/h1,4-12,14,19,21,33H,2-3,13,15-18H2
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n/an/a 0.930n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264098
PNG
(3-(3-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H27N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h1-2,5-11,13,18,20,29H,3-4,12,14-17H2
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n/an/a 0.980n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264113
PNG
(3-(3-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H25F2N5O/c28-21-15-25(29)27(35)34(18-21)23-6-4-22(5-7-23)33-12-10-32(11-13-33)9-1-2-20-17-31-26-8-3-19(16-30)14-24(20)26/h3-8,14-15,17-18,31H,1-2,9-13H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264124
PNG
(3-(4-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H32N6O/c28-19-21-5-10-26-25(18-21)22(20-30-26)4-1-2-12-31-14-16-32(17-15-31)23-6-8-24(9-7-23)33-13-3-11-29-27(33)34/h5-10,18,20,30H,1-4,11-17H2,(H,29,34)
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264125
PNG
(3-(3-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H30N6O/c27-18-20-4-9-25-24(17-20)21(19-29-25)3-1-11-30-13-15-31(16-14-30)22-5-7-23(8-6-22)32-12-2-10-28-26(32)33/h4-9,17,19,29H,1-3,10-16H2,(H,28,33)
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264112
PNG
(3-(4-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H27F2N5O/c29-22-16-26(30)28(36)35(19-22)24-7-5-23(6-8-24)34-13-11-33(12-14-34)10-2-1-3-21-18-32-27-9-4-20(17-31)15-25(21)27/h4-9,15-16,18-19,32H,1-3,10-14H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264101
PNG
(3-(5-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H31N5O/c30-21-23-8-13-28-27(20-23)24(22-31-28)6-2-1-4-14-32-16-18-33(19-17-32)25-9-11-26(12-10-25)34-15-5-3-7-29(34)35/h3,5,7-13,15,20,22,31H,1-2,4,6,14,16-19H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264097
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C27H29FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h2,4,6-12,14,19-20,29H,1,3,5,13,15-18H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264104
PNG
(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O/c1-22-11-13-34(29(35)18-22)26-8-6-25(7-9-26)33-16-14-32(15-17-33)12-3-2-4-24-21-31-28-10-5-23(20-30)19-27(24)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264109
PNG
(3-(3-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O2/c1-35-25-10-12-33(28(34)18-25)24-7-5-23(6-8-24)32-15-13-31(14-16-32)11-2-3-22-20-30-27-9-4-21(19-29)17-26(22)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264011
PNG
(3-(4-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H33N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h7-12,19,21,30H,1-6,13-18H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264123
PNG
(3-(3-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H26N6O/c27-17-20-3-8-25-24(16-20)21(18-29-25)2-1-10-30-12-14-31(15-13-30)22-4-6-23(7-5-22)32-11-9-28-19-26(32)33/h3-9,11,16,18-19,29H,1-2,10,12-15H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264106
PNG
(3-(2-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C27H27N5O/c1-20-8-11-32(27(33)16-20)24-5-3-23(4-6-24)31-14-12-30(13-15-31)10-9-22-19-29-26-7-2-21(18-28)17-25(22)26/h2-8,11,16-17,19,29H,9-10,12-15H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264115
PNG
(3-(5-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H29F2N5O/c30-23-17-27(31)29(37)36(20-23)25-8-6-24(7-9-25)35-14-12-34(13-15-35)11-3-1-2-4-22-19-33-28-10-5-21(18-32)16-26(22)28/h5-10,16-17,19-20,33H,1-4,11-15H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264093
PNG
(3-(4-(4-(4-(3-oxomorpholino)phenyl)piperazin-1-yl)...)
Show SMILES O=C1COCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O2/c28-18-21-4-9-26-25(17-21)22(19-29-26)3-1-2-10-30-11-13-31(14-12-30)23-5-7-24(8-6-23)32-15-16-34-20-27(32)33/h4-9,17,19,29H,1-3,10-16,20H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264100
PNG
(3-(2-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H25N5O/c27-18-20-4-9-25-24(17-20)21(19-28-25)10-12-29-13-15-30(16-14-29)22-5-7-23(8-6-22)31-11-2-1-3-26(31)32/h1-9,11,17,19,28H,10,12-16H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264107
PNG
(3-(5-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C30H33N5O/c1-23-12-14-35(30(36)19-23)27-9-7-26(8-10-27)34-17-15-33(16-18-34)13-4-2-3-5-25-22-32-29-11-6-24(21-31)20-28(25)29/h6-12,14,19-20,22,32H,2-5,13,15-18H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264121
PNG
(3-(3-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H27N5O2/c30-19-21-3-8-27-26(18-21)22(20-31-27)2-1-11-32-13-15-33(16-14-32)23-4-6-24(7-5-23)34-12-9-28-25(29(34)35)10-17-36-28/h3-10,12,17-18,20,31H,1-2,11,13-16H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264024
PNG
(1-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)N3CCCCC3=O)c2c1
Show InChI InChI=1S/C26H31FN4O/c27-21-6-11-25-24(18-21)20(19-28-25)4-3-12-29-14-16-30(17-15-29)22-7-9-23(10-8-22)31-13-2-1-5-26(31)32/h6-11,18-19,28H,1-5,12-17H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM263988
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)N3CCCCC3=O)c2c1
Show InChI InChI=1S/C27H33FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h7-12,19-20,29H,1-6,13-18H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264117
PNG
(3-(3-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Show SMILES O=c1n(ccc2ccccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C31H29N5O/c32-21-23-7-12-30-29(20-23)25(22-33-30)5-3-14-34-16-18-35(19-17-34)26-8-10-27(11-9-26)36-15-13-24-4-1-2-6-28(24)31(36)37/h1-2,4,6-13,15,20,22,33H,3,5,14,16-19H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264111
PNG
(3-(5-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C30H33N5O2/c1-37-27-12-14-35(30(36)20-27)26-9-7-25(8-10-26)34-17-15-33(16-18-34)13-4-2-3-5-24-22-32-29-11-6-23(21-31)19-28(24)29/h6-12,14,19-20,22,32H,2-5,13,15-18H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264114
PNG
(3-(2-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H23F2N5O/c27-20-14-24(28)26(34)33(17-20)22-4-2-21(3-5-22)32-11-9-31(10-12-32)8-7-19-16-30-25-6-1-18(15-29)13-23(19)25/h1-6,13-14,16-17,30H,7-12H2
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n/an/a 5.5n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264092
PNG
(4-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)N3CCOCC3=O)c2c1
Show InChI InChI=1S/C26H31FN4O2/c27-21-4-9-25-24(17-21)20(18-28-25)3-1-2-10-29-11-13-30(14-12-29)22-5-7-23(8-6-22)31-15-16-33-19-26(31)32/h4-9,17-18,28H,1-3,10-16,19H2
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n/an/a 6.30n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264099
PNG
(1-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C26H27FN4O/c27-21-6-11-25-24(18-21)20(19-28-25)4-3-12-29-14-16-30(17-15-29)22-7-9-23(10-8-22)31-13-2-1-5-26(31)32/h1-2,5-11,13,18-19,28H,3-4,12,14-17H2
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n/an/a 7.10n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264094
PNG
(4-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)N3CCOCC3=O)c2c1
Show InChI InChI=1S/C25H29FN4O2/c26-20-3-8-24-23(16-20)19(17-27-24)2-1-9-28-10-12-29(13-11-28)21-4-6-22(7-5-21)30-14-15-32-18-25(30)31/h3-8,16-17,27H,1-2,9-15,18H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264108
PNG
(3-(4-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O2/c1-36-26-11-13-34(29(35)19-26)25-8-6-24(7-9-25)33-16-14-32(15-17-33)12-3-2-4-23-21-31-28-10-5-22(20-30)18-27(23)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
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n/an/a 7.40n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264105
PNG
(3-(3-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O/c1-21-10-12-33(28(34)17-21)25-7-5-24(6-8-25)32-15-13-31(14-16-32)11-2-3-23-20-30-27-9-4-22(19-29)18-26(23)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264096
PNG
(3-(4-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H29N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h2,4,6-12,14,19,21,30H,1,3,5,13,15-18H2
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n/an/a 8n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264091
PNG
(3-(3-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h6-11,18,20,29H,1-5,12-17H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264095
PNG
(3-(3-(4-(4-(3-oxomorpholino)phenyl)piperazin-1-yl)...)
Show SMILES O=C1COCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H29N5O2/c27-17-20-3-8-25-24(16-20)21(18-28-25)2-1-9-29-10-12-30(13-11-29)22-4-6-23(7-5-22)31-14-15-33-19-26(31)32/h3-8,16,18,28H,1-2,9-15,19H2
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n/an/a 10n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264116
PNG
(3-(4-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Show SMILES O=c1n(ccc2ccccc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C32H31N5O/c33-22-24-8-13-31-30(21-24)26(23-34-31)6-3-4-15-35-17-19-36(20-18-35)27-9-11-28(12-10-27)37-16-14-25-5-1-2-7-29(25)32(37)38/h1-2,5,7-14,16,21,23,34H,3-4,6,15,17-20H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264110
PNG
(3-(2-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C27H27N5O2/c1-34-24-9-11-32(27(33)17-24)23-5-3-22(4-6-23)31-14-12-30(13-15-31)10-8-21-19-29-26-7-2-20(18-28)16-25(21)26/h2-7,9,11,16-17,19,29H,8,10,12-15H2,1H3
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n/an/a 12n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264103
PNG
(3-(1-hydroxy-3-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES OC(CCN1CCN(CC1)c1ccc(cc1)-n1ccccc1=O)c1c[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C27H27N5O2/c28-18-20-4-9-25-23(17-20)24(19-29-25)26(33)10-12-30-13-15-31(16-14-30)21-5-7-22(8-6-21)32-11-2-1-3-27(32)34/h1-9,11,17,19,26,29,33H,10,12-16H2
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n/an/a 170n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264102
PNG
(3-(1-hydroxy-4-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES OC(CCCN1CCN(CC1)c1ccc(cc1)-n1ccccc1=O)c1c[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C28H29N5O2/c29-19-21-6-11-26-24(18-21)25(20-30-26)27(34)4-3-12-31-14-16-32(17-15-31)22-7-9-23(10-8-22)33-13-2-1-5-28(33)35/h1-2,5-11,13,18,20,27,30,34H,3-4,12,14-17H2
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%