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Patent code US9714247

Compile Data Set for Download or QSAR

Found 452 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264334
PNG
(US9714247, 55)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C(C)CCO)c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C29H35N5O3/c1-4-33(5-2)14-16-37-24-11-12-27(31-20-24)32-28-18-26-23(19-30-28)17-25(22-9-7-6-8-10-22)29(36)34(26)21(3)13-15-35/h6-12,17-21,35H,4-5,13-16H2,1-3H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264360
PNG
(US9714247, 81)
Show SMILES Fc1ccc(Nc2cc3n(-c4ccccc4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C25H15F3N4O/c26-16-9-10-22(30-14-16)31-23-12-21-15(13-29-23)11-18(24-19(27)7-4-8-20(24)28)25(33)32(21)17-5-2-1-3-6-17/h1-14H,(H,29,30,31)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264361
PNG
(US9714247, 82)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(-c4ccncc4)c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C30H30N6O2/c1-3-35(4-2)16-17-38-25-10-11-28(33-21-25)34-29-19-27-23(20-32-29)18-26(22-8-6-5-7-9-22)30(37)36(27)24-12-14-31-15-13-24/h5-15,18-21H,3-4,16-17H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264372
PNG
(US9714247, 93)
Show SMILES CCn1c2cc(Nc3ccc(OCCN4CCN(C)CC4)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C28H30F2N6O2/c1-3-36-24-16-26(31-17-19(24)15-21(28(36)37)27-22(29)5-4-6-23(27)30)33-25-8-7-20(18-32-25)38-14-13-35-11-9-34(2)10-12-35/h4-8,15-18H,3,9-14H2,1-2H3,(H,31,32,33)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264372
PNG
(US9714247, 93)
Show SMILES CCn1c2cc(Nc3ccc(OCCN4CCN(C)CC4)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C28H30F2N6O2/c1-3-36-24-16-26(31-17-19(24)15-21(28(36)37)27-22(29)5-4-6-23(27)30)33-25-8-7-20(18-32-25)38-14-13-35-11-9-34(2)10-12-35/h4-8,15-18H,3,9-14H2,1-2H3,(H,31,32,33)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264374
PNG
(US9714247, 95)
Show SMILES CCn1c2cc(Nc3ccc(cn3)N(C)C3CCN(C)CC3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C28H30F2N6O/c1-4-36-24-15-26(31-16-18(24)14-21(28(36)37)27-22(29)6-5-7-23(27)30)33-25-9-8-20(17-32-25)35(3)19-10-12-34(2)13-11-19/h5-9,14-17,19H,4,10-13H2,1-3H3,(H,31,32,33)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264375
PNG
(US9714247, 96)
Show SMILES CCn1c2cc(Nc3ccc(CN4CCN(C)CC4)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C27H28F2N6O/c1-3-35-23-14-25(32-24-8-7-18(15-30-24)17-34-11-9-33(2)10-12-34)31-16-19(23)13-20(27(35)36)26-21(28)5-4-6-22(26)29/h4-8,13-16H,3,9-12,17H2,1-2H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264375
PNG
(US9714247, 96)
Show SMILES CCn1c2cc(Nc3ccc(CN4CCN(C)CC4)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C27H28F2N6O/c1-3-35-23-14-25(32-24-8-7-18(15-30-24)17-34-11-9-33(2)10-12-34)31-16-19(23)13-20(27(35)36)26-21(28)5-4-6-22(26)29/h4-8,13-16H,3,9-12,17H2,1-2H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264379
PNG
(US9714247, 100)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2ccc(F)cc2F)nc1
Show InChI InChI=1S/C27H29F2N5O2/c1-4-33(5-2)11-12-36-20-8-10-25(31-17-20)32-26-15-24-18(16-30-26)13-22(27(35)34(24)6-3)21-9-7-19(28)14-23(21)29/h7-10,13-17H,4-6,11-12H2,1-3H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264380
PNG
(US9714247, 101)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C27H29Cl2N5O2/c1-4-33(5-2)12-13-36-19-10-11-24(31-17-19)32-25-15-23-18(16-30-25)14-20(27(35)34(23)6-3)26-21(28)8-7-9-22(26)29/h7-11,14-17H,4-6,12-13H2,1-3H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264386
PNG
(US9714247, 107)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2ccccc2C(F)(F)F)nc1
Show InChI InChI=1S/C28H30F3N5O2/c1-4-35(5-2)13-14-38-20-11-12-25(33-18-20)34-26-16-24-19(17-32-26)15-22(27(37)36(24)6-3)21-9-7-8-10-23(21)28(29,30)31/h7-12,15-18H,4-6,13-14H2,1-3H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264388
PNG
(US9714247, 109)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2c(O)cccc2Cl)nc1
Show InChI InChI=1S/C27H30ClN5O3/c1-4-32(5-2)12-13-36-19-10-11-24(30-17-19)31-25-15-22-18(16-29-25)14-20(27(35)33(22)6-3)26-21(28)8-7-9-23(26)34/h7-11,14-17,34H,4-6,12-13H2,1-3H3,(H,29,30,31)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264390
PNG
(US9714247, 111)
Show SMILES CCn1c2cc(Nc3ccc(CN4CCN(CC4)S(C)(=O)=O)cn3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C27H30N6O3S/c1-3-33-24-16-26(29-18-22(24)15-23(27(33)34)21-7-5-4-6-8-21)30-25-10-9-20(17-28-25)19-31-11-13-32(14-12-31)37(2,35)36/h4-10,15-18H,3,11-14,19H2,1-2H3,(H,28,29,30)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264395
PNG
(US9714247, 117)
Show SMILES CCn1c2cc(Nc3ccc(cn3)N(C)C3CCN(C)CC3)ncc2cc(-c2cc(SC)ccc2F)c1=O
Show InChI InChI=1S/C29H33FN6OS/c1-5-36-26-16-28(33-27-9-6-21(18-32-27)35(3)20-10-12-34(2)13-11-20)31-17-19(26)14-24(29(36)37)23-15-22(38-4)7-8-25(23)30/h6-9,14-18,20H,5,10-13H2,1-4H3,(H,31,32,33)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264408
PNG
(US9714247, 130)
Show SMILES CN(C)CCCn1c2cc(Nc3ccc(F)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C24H22F3N5O/c1-31(2)9-4-10-32-20-12-22(30-21-8-7-16(25)14-29-21)28-13-15(20)11-17(24(32)33)23-18(26)5-3-6-19(23)27/h3,5-8,11-14H,4,9-10H2,1-2H3,(H,28,29,30)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264412
PNG
(US9714247, 134)
Show SMILES CN1CCN(CCn2c3cc(Nc4ccc(F)cn4)ncc3cc(-c3c(F)cccc3F)c2=O)CC1
Show InChI InChI=1S/C26H25F3N6O/c1-33-7-9-34(10-8-33)11-12-35-22-14-24(32-23-6-5-18(27)16-31-23)30-15-17(22)13-19(26(35)36)25-20(28)3-2-4-21(25)29/h2-6,13-16H,7-12H2,1H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264412
PNG
(US9714247, 134)
Show SMILES CN1CCN(CCn2c3cc(Nc4ccc(F)cn4)ncc3cc(-c3c(F)cccc3F)c2=O)CC1
Show InChI InChI=1S/C26H25F3N6O/c1-33-7-9-34(10-8-33)11-12-35-22-14-24(32-23-6-5-18(27)16-31-23)30-15-17(22)13-19(26(35)36)25-20(28)3-2-4-21(25)29/h2-6,13-16H,7-12H2,1H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264414
PNG
(US9714247, 136)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C4CC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C29H30F2N6O/c1-35-12-10-19(11-13-35)36(2)21-8-9-26(33-17-21)34-27-15-25-18(16-32-27)14-22(29(38)37(25)20-6-7-20)28-23(30)4-3-5-24(28)31/h3-5,8-9,14-17,19-20H,6-7,10-13H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264416
PNG
(US9714247, 138)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C4CCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C30H32F2N6O/c1-36-13-11-20(12-14-36)37(2)22-9-10-27(34-18-22)35-28-16-26-19(17-33-28)15-23(29-24(31)7-4-8-25(29)32)30(39)38(26)21-5-3-6-21/h4,7-10,15-18,20-21H,3,5-6,11-14H2,1-2H3,(H,33,34,35)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264416
PNG
(US9714247, 138)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C4CCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C30H32F2N6O/c1-36-13-11-20(12-14-36)37(2)22-9-10-27(34-18-22)35-28-16-26-19(17-33-28)15-23(29-24(31)7-4-8-25(29)32)30(39)38(26)21-5-3-6-21/h4,7-10,15-18,20-21H,3,5-6,11-14H2,1-2H3,(H,33,34,35)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264417
PNG
(US9714247, 139)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C4CCCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C31H34F2N6O/c1-37-14-12-21(13-15-37)38(2)23-10-11-28(35-19-23)36-29-17-27-20(18-34-29)16-24(30-25(32)8-5-9-26(30)33)31(40)39(27)22-6-3-4-7-22/h5,8-11,16-19,21-22H,3-4,6-7,12-15H2,1-2H3,(H,34,35,36)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264419
PNG
(US9714247, 141 | US9714247, 142)
Show SMILES Fc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C23H17F3N4O2/c24-14-4-5-20(28-11-14)29-21-9-19-13(10-27-21)8-16(22-17(25)2-1-3-18(22)26)23(31)30(19)15-6-7-32-12-15/h1-5,8-11,15H,6-7,12H2,(H,27,28,29)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264421
PNG
(US9714247, 143 | US9714247, 144)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C29H31F2N5O3/c1-3-35(4-2)11-13-39-21-8-9-26(33-17-21)34-27-15-25-19(16-32-27)14-22(28-23(30)6-5-7-24(28)31)29(37)36(25)20-10-12-38-18-20/h5-9,14-17,20H,3-4,10-13,18H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264423
PNG
(US9714247, 145 | US9714247, 146)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C29H31Cl2N5O3/c1-3-35(4-2)11-13-39-21-8-9-26(33-17-21)34-27-15-25-19(16-32-27)14-22(28-23(30)6-5-7-24(28)31)29(37)36(25)20-10-12-38-18-20/h5-9,14-17,20H,3-4,10-13,18H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264423
PNG
(US9714247, 145 | US9714247, 146)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C29H31Cl2N5O3/c1-3-35(4-2)11-13-39-21-8-9-26(33-17-21)34-27-15-25-19(16-32-27)14-22(28-23(30)6-5-7-24(28)31)29(37)36(25)20-10-12-38-18-20/h5-9,14-17,20H,3-4,10-13,18H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264293
PNG
(US9714247, 14)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C25H27N5O2/c1-3-30(4-2)12-13-32-20-10-11-23(27-17-20)29-24-15-22-19(16-26-24)14-21(25(31)28-22)18-8-6-5-7-9-18/h5-11,14-17H,3-4,12-13H2,1-2H3,(H,28,31)(H,26,27,29)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264295
PNG
(US9714247, 16)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCN(C)CC4)c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C31H38N6O2/c1-4-36(5-2)17-18-39-26-11-12-29(33-22-26)34-30-20-28-24(21-32-30)19-27(23-9-7-6-8-10-23)31(38)37(28)25-13-15-35(3)16-14-25/h6-12,19-22,25H,4-5,13-18H2,1-3H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264302
PNG
(US9714247, 23)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCCC4)c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C30H35N5O2/c1-3-34(4-2)16-17-37-25-14-15-28(32-21-25)33-29-19-27-23(20-31-29)18-26(22-10-6-5-7-11-22)30(36)35(27)24-12-8-9-13-24/h5-7,10-11,14-15,18-21,24H,3-4,8-9,12-13,16-17H2,1-2H3,(H,31,32,33)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264304
PNG
(US9714247, 25)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCC4)c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C29H33N5O2/c1-3-33(4-2)15-16-36-24-13-14-27(31-20-24)32-28-18-26-22(19-30-28)17-25(21-9-6-5-7-10-21)29(35)34(26)23-11-8-12-23/h5-7,9-10,13-14,17-20,23H,3-4,8,11-12,15-16H2,1-2H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264313
PNG
(US9714247, 34)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C(C)C)c(=O)c(cc3cn2)C(C)C)nc1
Show InChI InChI=1S/C25H35N5O2/c1-7-29(8-2)11-12-32-20-9-10-23(27-16-20)28-24-14-22-19(15-26-24)13-21(17(3)4)25(31)30(22)18(5)6/h9-10,13-18H,7-8,11-12H2,1-6H3,(H,26,27,28)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264314
PNG
(US9714247, 35)
Show SMILES CCn1c2cc(Nc3ccc(C)cn3)ncc2cc(-c2ccccc2F)c1=O
Show InChI InChI=1S/C22H19FN4O/c1-3-27-19-11-21(26-20-9-8-14(2)12-24-20)25-13-15(19)10-17(22(27)28)16-6-4-5-7-18(16)23/h4-13H,3H2,1-2H3,(H,24,25,26)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264345
PNG
(US9714247, 66)
Show SMILES CCn1c2cc(Nc3ccc(NCCO)cn3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C23H23N5O2/c1-2-28-20-13-22(27-21-9-8-18(15-26-21)24-10-11-29)25-14-17(20)12-19(23(28)30)16-6-4-3-5-7-16/h3-9,12-15,24,29H,2,10-11H2,1H3,(H,25,26,27)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264346
PNG
(US9714247, 67)
Show SMILES CCn1c2cc(Nc3ccc(NCCN(C)C)cn3)ncc2cc(-c2ccccc2)c1=O
Show InChI InChI=1S/C25H28N6O/c1-4-31-22-15-24(29-23-11-10-20(17-28-23)26-12-13-30(2)3)27-16-19(22)14-21(25(31)32)18-8-6-5-7-9-18/h5-11,14-17,26H,4,12-13H2,1-3H3,(H,27,28,29)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264350
PNG
(US9714247, 71)
Show SMILES CCn1c2cc(Nc3ccc(F)cn3)ncc2cc(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C21H16ClFN4O/c1-2-27-18-10-20(26-19-8-7-14(23)12-25-19)24-11-13(18)9-16(21(27)28)15-5-3-4-6-17(15)22/h3-12H,2H2,1H3,(H,24,25,26)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264356
PNG
(US9714247, 77)
Show SMILES Fc1ccc(Nc2cc3n(C4CCCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H19F3N4O/c25-15-8-9-21(29-13-15)30-22-11-20-14(12-28-22)10-17(23-18(26)6-3-7-19(23)27)24(32)31(20)16-4-1-2-5-16/h3,6-13,16H,1-2,4-5H2,(H,28,29,30)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264365
PNG
(US9714247, 86)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2ccccc2)cc1
Show InChI InChI=1S/C28H32N4O2/c1-4-31(5-2)16-17-34-24-14-12-23(13-15-24)30-27-19-26-22(20-29-27)18-25(28(33)32(26)6-3)21-10-8-7-9-11-21/h7-15,18-20H,4-6,16-17H2,1-3H3,(H,29,30)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264398
PNG
(US9714247, 120)
Show SMILES CCn1c2cc(Nc3ccc(cn3)N(C)C3CCN(C)CC3)ncc2cc(-c2c(O)cccc2F)c1=O
Show InChI InChI=1S/C28H31FN6O2/c1-4-35-23-15-26(30-16-18(23)14-21(28(35)37)27-22(29)6-5-7-24(27)36)32-25-9-8-20(17-31-25)34(3)19-10-12-33(2)13-11-19/h5-9,14-17,19,36H,4,10-13H2,1-3H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264398
PNG
(US9714247, 120)
Show SMILES CCn1c2cc(Nc3ccc(cn3)N(C)C3CCN(C)CC3)ncc2cc(-c2c(O)cccc2F)c1=O
Show InChI InChI=1S/C28H31FN6O2/c1-4-35-23-15-26(30-16-18(23)14-21(28(35)37)27-22(29)6-5-7-24(27)36)32-25-9-8-20(17-31-25)34(3)19-10-12-33(2)13-11-19/h5-9,14-17,19,36H,4,10-13H2,1-3H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264408
PNG
(US9714247, 130)
Show SMILES CN(C)CCCn1c2cc(Nc3ccc(F)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C24H22F3N5O/c1-31(2)9-4-10-32-20-12-22(30-21-8-7-16(25)14-29-21)28-13-15(20)11-17(24(32)33)23-18(26)5-3-6-19(23)27/h3,5-8,11-14H,4,9-10H2,1-2H3,(H,28,29,30)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264410
PNG
(US9714247, 132)
Show SMILES CN1CCN(CCCn2c3cc(Nc4ccc(F)cn4)ncc3cc(-c3c(F)cccc3F)c2=O)CC1
Show InChI InChI=1S/C27H27F3N6O/c1-34-10-12-35(13-11-34)8-3-9-36-23-15-25(33-24-7-6-19(28)17-32-24)31-16-18(23)14-20(27(36)37)26-21(29)4-2-5-22(26)30/h2,4-7,14-17H,3,8-13H2,1H3,(H,31,32,33)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264413
PNG
(US9714247, 135)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C27H28F2N6O/c1-33-11-9-18(10-12-33)34(2)19-7-8-24(31-16-19)32-25-14-23-17(15-30-25)13-20(27(36)35(23)3)26-21(28)5-4-6-22(26)29/h4-8,13-16,18H,9-12H2,1-3H3,(H,30,31,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264417
PNG
(US9714247, 139)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C4CCCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C31H34F2N6O/c1-37-14-12-21(13-15-37)38(2)23-10-11-28(35-19-23)36-29-17-27-20(18-34-29)16-24(30-25(32)8-5-9-26(30)33)31(40)39(27)22-6-3-4-7-22/h5,8-11,16-19,21-22H,3-4,6-7,12-15H2,1-2H3,(H,34,35,36)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264418
PNG
(US9714247, 140)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C26H26F2N6O/c1-33-10-8-17(9-11-33)34(2)18-6-7-23(30-15-18)32-24-13-22-16(14-29-24)12-19(26(35)31-22)25-20(27)4-3-5-21(25)28/h3-7,12-15,17H,8-11H2,1-2H3,(H,31,35)(H,29,30,32)
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n/an/a<100n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264423
PNG
(US9714247, 145 | US9714247, 146)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C29H31Cl2N5O3/c1-3-35(4-2)11-13-39-21-8-9-26(33-17-21)34-27-15-25-19(16-32-27)14-22(28-23(30)6-5-7-24(28)31)29(37)36(25)20-10-12-38-18-20/h5-9,14-17,20H,3-4,10-13,18H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM264425
PNG
(US9714247, 147 | US9714247, 148)
Show SMILES Fc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C23H17Cl2FN4O2/c24-17-2-1-3-18(25)22(17)16-8-13-10-27-21(29-20-5-4-14(26)11-28-20)9-19(13)30(23(16)31)15-6-7-32-12-15/h1-5,8-11,15H,6-7,12H2,(H,27,28,29)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264418
PNG
(US9714247, 140)
Show SMILES CN(C1CCN(C)CC1)c1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C26H26F2N6O/c1-33-10-8-17(9-11-33)34(2)18-6-7-23(30-15-18)32-24-13-22-16(14-29-24)12-19(26(35)31-22)25-20(27)4-3-5-21(25)28/h3-7,12-15,17H,8-11H2,1-2H3,(H,31,35)(H,29,30,32)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264421
PNG
(US9714247, 143 | US9714247, 144)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C29H31F2N5O3/c1-3-35(4-2)11-13-39-21-8-9-26(33-17-21)34-27-15-25-19(16-32-27)14-22(28-23(30)6-5-7-24(28)31)29(37)36(25)20-10-12-38-18-20/h5-9,14-17,20H,3-4,10-13,18H2,1-2H3,(H,32,33,34)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM264425
PNG
(US9714247, 147 | US9714247, 148)
Show SMILES Fc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C23H17Cl2FN4O2/c24-17-2-1-3-18(25)22(17)16-8-13-10-27-21(29-20-5-4-14(26)11-28-20)9-19(13)30(23(16)31)15-6-7-32-12-15/h1-5,8-11,15H,6-7,12H2,(H,27,28,29)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264428
PNG
(US9714247, 150)
Show SMILES CN1CC[C@@H](C1)n1c2cc(Nc3ccc(F)cn3)ncc2cc(-c2c(F)cccc2F)c1=O
Show InChI InChI=1S/C24H20F3N5O/c1-31-8-7-16(13-31)32-20-10-22(30-21-6-5-15(25)12-29-21)28-11-14(20)9-17(24(32)33)23-18(26)3-2-4-19(23)27/h2-6,9-12,16H,7-8,13H2,1H3,(H,28,29,30)/t16-/m0/s1
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264280
PNG
(US9714247, 1)
Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2ccccc2)nc1
Show InChI InChI=1S/C27H31N5O2/c1-4-31(5-2)14-15-34-22-12-13-25(29-19-22)30-26-17-24-21(18-28-26)16-23(27(33)32(24)6-3)20-10-8-7-9-11-20/h7-13,16-19H,4-6,14-15H2,1-3H3,(H,28,29,30)
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Tolero Pharmaceuticals, Inc.; Mannkind Corporation

US Patent


Assay Description
A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...


US Patent US9714247 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 452 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%