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Patent code US9717745

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260571
PNG
(US9532990, 45 | US9717745, 3)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H17F5N6O2/c1-2-17(36)34-6-5-11(9-34)35-24-18(23(30)31-10-32-24)21(33-35)13-4-3-12(7-14(13)25)37-22-19(28)15(26)8-16(27)20(22)29/h2-4,7-8,10-11H,1,5-6,9H2,(H2,30,31,32)/t11-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



ZHEJIANG DTRM BIOPHARMA CO. LTD.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


US Patent US9717745 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260620
PNG
(US9532990, 94 | US9717745, 5)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H20F2N6O2/c1-2-20(33)31-9-8-15(12-31)32-24-21(23(27)28-13-29-24)22(30-32)18-7-6-17(11-19(18)26)34-16-5-3-4-14(25)10-16/h2-7,10-11,13,15H,1,8-9,12H2,(H2,27,28,29)/t15-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



ZHEJIANG DTRM BIOPHARMA CO. LTD.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


US Patent US9717745 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260559
PNG
(US9532990, 33 | US9717745, 1)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)35-7-3-4-12(10-35)36-25-19(24(31)32-11-33-25)22(34-36)14-6-5-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2,5-6,8-9,11-12H,1,3-4,7,10H2,(H2,31,32,33)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



ZHEJIANG DTRM BIOPHARMA CO. LTD.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


US Patent US9717745 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260572
PNG
(US9532990, 46 | US9717745, 4)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H17F5N6O2/c1-2-17(36)34-6-5-11(9-34)35-24-18(23(30)31-10-32-24)21(33-35)13-4-3-12(7-14(13)25)37-22-19(28)15(26)8-16(27)20(22)29/h2-4,7-8,10-11H,1,5-6,9H2,(H2,30,31,32)/t11-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



ZHEJIANG DTRM BIOPHARMA CO. LTD.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


US Patent US9717745 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260560
PNG
(US9532990, 34 | US9717745, 2)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)35-7-3-4-12(10-35)36-25-19(24(31)32-11-33-25)22(34-36)14-6-5-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2,5-6,8-9,11-12H,1,3-4,7,10H2,(H2,31,32,33)/t12-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



ZHEJIANG DTRM BIOPHARMA CO. LTD.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


US Patent US9717745 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%