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Patent code US9718803

Compile Data Set for Download or QSAR

Found 375 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM267012
PNG
(2-(3-(3-(2,2-dimethyl-3,6- dihydro-2H-pyran-4-yl)p...)
Show SMILES CC1(C)OCCC(=C1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H24N4O/c1-23(2)13-17(9-12-28-23)21-22(25-11-10-24-21)18-14-27(15-18)20-8-7-16-5-3-4-6-19(16)26-20/h3-8,10-11,13,18H,9,12,14-15H2,1-2H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146707
PNG
(US8957073, 4.41 | US9718803, 4.41)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1C1=CCOCC1
Show InChI InChI=1S/C21H20N4O/c1-2-4-18-15(3-1)5-6-19(24-18)25-13-17(14-25)21-20(22-9-10-23-21)16-7-11-26-12-8-16/h1-7,9-10,17H,8,11-14H2
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n/an/a 0.00100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146672
PNG
(US8957073, 4.6 | US9718803, 4.6)
Show SMILES COc1ccc(c(OC)n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H21N5O2/c1-29-20-10-8-17(23(27-20)30-2)22-21(24-11-12-25-22)16-13-28(14-16)19-9-7-15-5-3-4-6-18(15)26-19/h3-12,16H,13-14H2,1-2H3
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n/an/a 0.00100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146689
PNG
(US8957073, 4.23 | US9718803, 4.23)
Show SMILES Oc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H17ClN4O/c23-17-11-15(5-7-19(17)28)21-22(25-10-9-24-21)16-12-27(13-16)20-8-6-14-3-1-2-4-18(14)26-20/h1-11,16,28H,12-13H2
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21 | US9718803, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00200n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146667
PNG
(US8957073, 4.1 | US9718803, 4.1)
Show SMILES COc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-22-17(6-4-10-25-22)21-20(23-11-12-24-21)16-13-27(14-16)19-9-8-15-5-2-3-7-18(15)26-19/h2-12,16H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146678
PNG
(US8957073, 4.12 | US9718803, 4.12)
Show SMILES Nc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2,(H2,22,25)
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146677
PNG
(US8957073, 4.11 | US9718803, 4.11)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H20N4O2S/c1-30(28,29)19-9-6-17(7-10-19)22-23(25-13-12-24-22)18-14-27(15-18)21-11-8-16-4-2-3-5-20(16)26-21/h2-13,18H,14-15H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146668
PNG
(US8957073, 4.2 | US9718803, 4.2)
Show SMILES Cc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146695
PNG
(US8957073, 4.29 | US9718803, 4.29)
Show SMILES COc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-16-13-18(7-9-21(16)29-2)23-24(26-12-11-25-23)19-14-28(15-19)22-10-8-17-5-3-4-6-20(17)27-22/h3-13,19H,14-15H2,1-2H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32 | US9718803, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146688
PNG
(US8957073, 4.22 | US9718803, 4.22)
Show SMILES Cc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146679
PNG
(US8957073, 4.13 | US9718803, 4.13)
Show SMILES Nc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13,22H2
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146670
PNG
(US8957073, 4.4 | US9718803, 4.4)
Show SMILES Fc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31 | US9718803, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35 | US9718803, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146669
PNG
(US8957073, 4.3 | US9718803, 4.3)
Show SMILES Cc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-18(6-4-10-23-15)22-21(24-11-12-25-22)17-13-27(14-17)20-9-8-16-5-2-3-7-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.00600n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25 | US9718803, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146704
PNG
(US8957073, 4.38 | US9718803, 4.38)
Show SMILES Cc1cc(ccc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00600n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146703
PNG
(US8957073, 4.37 | US9718803, 4.37)
Show SMILES Cc1cc(Cl)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00700n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146709
PNG
(US8957073, 4.43 | US9718803, 4.43)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cn[nH]c1
Show InChI InChI=1S/C19H16N6/c1-2-4-16-13(3-1)5-6-17(24-16)25-11-15(12-25)19-18(20-7-8-21-19)14-9-22-23-10-14/h1-10,15H,11-12H2,(H,22,23)
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n/an/a 0.00700n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36 | US9718803, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00700n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146700
PNG
(US8957073, 4.34 | US9718803, 4.34)
Show SMILES Clc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16Cl2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00800n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146674
PNG
(US8957073, 4.8 | US9718803, 4.8)
Show SMILES COc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-9-7-16(12-25-20)21-22(24-11-10-23-21)17-13-27(14-17)19-8-6-15-4-2-3-5-18(15)26-19/h2-12,17H,13-14H2,1H3
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n/an/a 0.00800n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146676
PNG
(US8957073, 4.10 | US9718803, 4.10)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cccnc1
Show InChI InChI=1S/C21H17N5/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2
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n/an/a 0.00800n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146706
PNG
(US8957073, 4.40 | US9718803, 4.40)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16ClF3N4/c24-18-7-5-15(11-17(18)23(25,26)27)21-22(29-10-9-28-21)16-12-31(13-16)20-8-6-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.00900n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146699
PNG
(US8957073, 4.33 | US9718803, 4.33)
Show SMILES Fc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.0100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146692
PNG
(US8957073, 4.26 | US9718803, 4.26)
Show SMILES CCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21ClN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.0110n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146696
PNG
(US8957073, 4.30 | US9718803, 4.30)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23FN4O/c1-16(2)31-21-12-18(11-20(26)13-21)24-25(28-10-9-27-24)19-14-30(15-19)23-8-7-17-5-3-4-6-22(17)29-23/h3-13,16,19H,14-15H2,1-2H3
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n/an/a 0.0110n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44 | US9718803, 4.4...)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.0120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146675
PNG
(US8957073, 4.9 | US9718803, 4.9)
Show SMILES Cc1cc(cnc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H18FN5/c1-14-10-16(11-26-22(14)23)20-21(25-9-8-24-20)17-12-28(13-17)19-7-6-15-4-2-3-5-18(15)27-19/h2-11,17H,12-13H2,1H3
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n/an/a 0.0120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44 | US9718803, 4.4...)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146673
PNG
(US8957073, 4.7 | US9718803, 4.7)
Show SMILES Fc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13H2
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146671
PNG
(US8957073, 4.5 | US9718803, 4.5)
Show SMILES FC(F)(F)c1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F3N5/c23-22(24,25)18-7-5-15(11-28-18)20-21(27-10-9-26-20)16-12-30(13-16)19-8-6-14-3-1-2-4-17(14)29-19/h1-11,16H,12-13H2
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n/an/a 0.0140n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146690
PNG
(US8957073, 4.24 | US9718803, 4.24)
Show SMILES COc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H19F3N4O/c1-32-19-11-16(10-18(12-19)24(25,26)27)22-23(29-9-8-28-22)17-13-31(14-17)21-7-6-15-4-2-3-5-20(15)30-21/h2-12,17H,13-14H2,1H3
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n/an/a 0.0150n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146685
PNG
(US8957073, 4.19 | US9718803, 4.19)
Show SMILES Cc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-10-17(12-23-11-15)21-22(25-9-8-24-21)18-13-27(14-18)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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n/an/a 0.0160n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146693
PNG
(US8957073, 4.27 | US9718803, 4.27)
Show SMILES CCCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23ClN4O/c1-2-13-31-22-9-7-18(14-20(22)26)24-25(28-12-11-27-24)19-15-30(16-19)23-10-8-17-5-3-4-6-21(17)29-23/h3-12,14,19H,2,13,15-16H2,1H3
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n/an/a 0.0170n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146682
PNG
(US8957073, 4.16 | US9718803, 4.16)
Show SMILES CN(C)c1ncc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H21N7/c1-28(2)22-25-11-16(12-26-22)20-21(24-10-9-23-20)17-13-29(14-17)19-8-7-15-5-3-4-6-18(15)27-19/h3-12,17H,13-14H2,1-2H3
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n/an/a 0.0230n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146686
PNG
(US8957073, 4.20 | US9718803, 4.20)
Show SMILES COc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-18-10-16(11-23-12-18)21-22(25-9-8-24-21)17-13-27(14-17)20-7-6-15-4-2-3-5-19(15)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.0250n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146683
PNG
(US8957073, 4.17 | US9718803, 4.17)
Show SMILES Cc1ccncc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-8-9-23-12-18(15)22-21(24-10-11-25-22)17-13-27(14-17)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.0260n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146705
PNG
(US8957073, 4.39 | US9718803, 4.39)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cncnc1
Show InChI InChI=1S/C20H16N6/c1-2-4-17-14(3-1)5-6-18(25-17)26-11-16(12-26)20-19(23-7-8-24-20)15-9-21-13-22-10-15/h1-10,13,16H,11-12H2
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n/an/a 0.0890n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146915
PNG
(US8957073, 28.14 | US9718803, 28.14)
Show SMILES OCC1CCN(CC1)c1nccnc1C1CN(C1)c1ncc2ccc(Cl)cc2n1
Show InChI InChI=1S/C21H23ClN6O/c22-17-2-1-15-10-25-21(26-18(15)9-17)28-11-16(12-28)19-20(24-6-5-23-19)27-7-3-14(13-29)4-8-27/h1-2,5-6,9-10,14,16,29H,3-4,7-8,11-13H2
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n/an/a 0.100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146903
PNG
(US8957073, 28.2 | US9718803, 28.2)
Show SMILES OCC1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C22H24FN5O/c23-18-3-1-16-2-4-20(26-19(16)11-18)28-12-17(13-28)21-22(25-8-7-24-21)27-9-5-15(14-29)6-10-27/h1-4,7-8,11,15,17,29H,5-6,9-10,12-14H2
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n/an/a 0.100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146681
PNG
(US8957073, 4.15 | US9718803, 4.15)
Show SMILES FC(F)(F)c1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F3N5/c23-22(24,25)21-16(5-3-9-28-21)20-19(26-10-11-27-20)15-12-30(13-15)18-8-7-14-4-1-2-6-17(14)29-18/h1-11,15H,12-13H2
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n/an/a 0.124n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146794
PNG
(US8957073, 6.41 | US9718803, 6.41)
Show SMILES N#CC1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H22N6/c23-13-16-7-11-27(12-8-16)22-21(24-9-10-25-22)18-14-28(15-18)20-6-5-17-3-1-2-4-19(17)26-20/h1-6,9-10,16,18H,7-8,11-12,14-15H2
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n/an/a 0.130n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146720
PNG
(US8957073, 5.9 | US9718803, 5.9)
Show SMILES COC(=O)c1cccc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20N4O2/c1-30-24(29)18-7-4-6-17(13-18)22-23(26-12-11-25-22)19-14-28(15-19)21-10-9-16-5-2-3-8-20(16)27-21/h2-13,19H,14-15H2,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146890
PNG
(US8957073, 24.3 | US9718803, 24.3)
Show SMILES NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H24N6O/c23-21(29)16-7-11-27(12-8-16)22-20(24-9-10-25-22)17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29)
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n/an/a 0.480n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM267208
PNG
((1-{3-[1-(7-Chloro- quinoxalin-2-yl)-azetidin-3- y...)
Show SMILES OCC1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccc(Cl)cc2n1
Show InChI InChI=1S/C22H24ClN5O/c23-18-3-1-16-2-4-20(26-19(16)11-18)28-12-17(13-28)21-22(25-8-7-24-21)27-9-5-15(14-29)6-10-27/h1-4,7-8,11,15,17,29H,5-6,9-10,12-14H2
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%