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Patent code US9718809

Compile Data Set for Download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267057
PNG
(2-Hydroxyethyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3...)
Show SMILES OCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O
Show InChI InChI=1S/C21H18FNO7S/c22-14-4-7-19(25)18(11-14)13-2-1-3-16(10-13)31(28,29)23-15-5-6-17(20(26)12-15)21(27)30-9-8-24/h1-7,10-12,23-26H,8-9H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267062
PNG
(Butyl 4-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-...)
Show SMILES CCCCOC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
Show InChI InChI=1S/C15H15Cl2NO5S2/c1-2-3-6-23-15(20)10-5-4-9(7-12(10)19)18-25(21,22)13-8-11(16)14(17)24-13/h4-5,7-8,18-19H,2-3,6H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267054
PNG
(2-(1H-Pyrrol-1-yl)ethyl 4-{[(4,5-dichlorothiophen-...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)ccc1C(=O)OCCn1cccc1
Show InChI InChI=1S/C17H14Cl2N2O5S2/c18-13-10-15(27-16(13)19)28(24,25)20-11-3-4-12(14(22)9-11)17(23)26-8-7-21-5-1-2-6-21/h1-6,9-10,20,22H,7-8H2
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n/an/a 600n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267074
PNG
(3-Morpholin-4-ylpropyl 4-({[5-chloro-4-(5-fluoro-2...)
Show SMILES CC1CN(CCCOC(=O)c2ccc(NS(=O)(=O)c3cc(c(Cl)s3)-c3cc(F)ccc3O)cc2O)CCO1
Show InChI InChI=1S/C25H26ClFN2O7S2/c1-15-14-29(8-10-35-15)7-2-9-36-25(32)18-5-4-17(12-22(18)31)28-38(33,34)23-13-20(24(26)37-23)19-11-16(27)3-6-21(19)30/h3-6,11-13,15,28,30-31H,2,7-10,14H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267055
PNG
(2-Methoxyethyl 4-({[3-(2,3-dihydro-1-benzofuran-5-...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc3OCCc3c2)cc1O
Show InChI InChI=1S/C24H23NO7S/c1-30-11-12-32-24(27)21-7-6-19(15-22(21)26)25-33(28,29)20-4-2-3-16(14-20)17-5-8-23-18(13-17)9-10-31-23/h2-8,13-15,25-26H,9-12H2,1H3
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n/an/a 700n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267082
PNG
(3-[(5-Methylisoxazol-3-yl)amino]propyl 4-{[(5'-flu...)
Show SMILES Cc1cc(NCCCOC(=O)c2ccc(NS(=O)(=O)c3cccc(c3)-c3cc(F)ccc3O)cc2O)no1
Show InChI InChI=1S/C26H24FN3O7S/c1-16-12-25(29-37-16)28-10-3-11-36-26(33)21-8-7-19(15-24(21)32)30-38(34,35)20-5-2-4-17(13-20)22-14-18(27)6-9-23(22)31/h2,4-9,12-15,30-32H,3,10-11H2,1H3,(H,28,29)
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n/an/a 800n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267064
PNG
(Benzyl 4-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)ccc1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H13Cl2NO5S2/c19-14-9-16(27-17(14)20)28(24,25)21-12-6-7-13(15(22)8-12)18(23)26-10-11-4-2-1-3-5-11/h1-9,21-22H,10H2
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n/an/a 800n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267065
PNG
(2-Methoxy-1-methylethyl 4-{[(4,5-dichlorothiophen-...)
Show SMILES COCC(C)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
Show InChI InChI=1S/C15H15Cl2NO6S2/c1-8(7-23-2)24-15(20)10-4-3-9(5-12(10)19)18-26(21,22)13-6-11(16)14(17)25-13/h3-6,8,18-19H,7H2,1-2H3
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n/an/a 800n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267031
PNG
(4-{[(5-Chloro-4-phenyl-2-thienyl)sulfonyl]amino}-2...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2)cc1O
Show InChI InChI=1S/C17H12ClNO5S2/c18-16-13(10-4-2-1-3-5-10)9-15(25-16)26(23,24)19-11-6-7-12(17(21)22)14(20)8-11/h1-9,19-20H,(H,21,22)
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n/an/a 800n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267031
PNG
(4-{[(5-Chloro-4-phenyl-2-thienyl)sulfonyl]amino}-2...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2)cc1O
Show InChI InChI=1S/C17H12ClNO5S2/c18-16-13(10-4-2-1-3-5-10)9-15(25-16)26(23,24)19-11-6-7-12(17(21)22)14(20)8-11/h1-9,19-20H,(H,21,22)
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n/an/a 900n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267066
PNG
(2-Methoxyethyl 4-({[5-chloro-4-(2,3-dihydro-1-benz...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccc3OCCc3c2)cc1O
Show InChI InChI=1S/C22H20ClNO7S2/c1-29-8-9-31-22(26)16-4-3-15(11-18(16)25)24-33(27,28)20-12-17(21(23)32-20)13-2-5-19-14(10-13)6-7-30-19/h2-5,10-12,24-25H,6-9H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267068
PNG
(General Procedure 9 | US9718809, 82)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C20H17NO6S/c1-27-20(24)17-10-9-14(12-19(17)23)21-28(25,26)15-6-4-5-13(11-15)16-7-2-3-8-18(16)22/h2-12,21-23H,1H3
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n/an/a 1.08E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267063
PNG
(1-Methyl-3-morpholin-4-ylpropyl 4-{[(4,5-dichlorot...)
Show SMILES CC(CCN1CCOCC1)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
Show InChI InChI=1S/C19H22Cl2N2O6S2/c1-12(4-5-23-6-8-28-9-7-23)29-19(25)14-3-2-13(10-16(14)24)22-31(26,27)17-11-15(20)18(21)30-17/h2-3,10-12,22,24H,4-9H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267035
PNG
(2-Methoxyethyl 4-({[5-chloro-4-(2-hydroxyphenyl)-2...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C20H18ClNO7S2/c1-28-8-9-29-20(25)14-7-6-12(10-17(14)24)22-31(26,27)18-11-15(19(21)30-18)13-4-2-3-5-16(13)23/h2-7,10-11,22-24H,8-9H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267030
PNG
(Methyl 2-hydroxy-4-({[(2'-hydroxybiphenyl-4-yl)met...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)Cc2ccc(cc2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C21H19NO6S/c1-28-21(25)18-11-10-16(12-20(18)24)22-29(26,27)13-14-6-8-15(9-7-14)17-4-2-3-5-19(17)23/h2-12,22-24H,13H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267061
PNG
(2-Methoxy-1-(methoxymethyl)ethyl 4-{[(3,5-dichloro...)
Show SMILES COCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1O
Show InChI InChI=1S/C18H19Cl2NO7S/c1-26-9-14(10-27-2)28-18(23)16-4-3-13(8-17(16)22)21-29(24,25)15-6-11(19)5-12(20)7-15/h3-8,14,21-22H,9-10H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267076
PNG
(2-Hydroxyethyl 4-{[(5-chloro-4-phenyl-2-thienyl)su...)
Show SMILES OCCOC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2)cc1O
Show InChI InChI=1S/C19H16ClNO6S2/c20-18-15(12-4-2-1-3-5-12)11-17(28-18)29(25,26)21-13-6-7-14(16(23)10-13)19(24)27-9-8-22/h1-7,10-11,21-23H,8-9H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267033
PNG
(Methyl 2-(acetyloxy)-4-{[(4,5-dichlorothiophen-2-y...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1OC(C)=O
Show InChI InChI=1S/C14H11Cl2NO6S2/c1-7(18)23-11-5-8(3-4-9(11)14(19)22-2)17-25(20,21)12-6-10(15)13(16)24-12/h3-6,17H,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267039
PNG
(Methyl 2-hydroxy-4-({[3-(piperidin-1-yl)phenyl]sul...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)N2CCCCC2)cc1O
Show InChI InChI=1S/C19H22N2O5S/c1-26-19(23)17-9-8-14(12-18(17)22)20-27(24,25)16-7-5-6-15(13-16)21-10-3-2-4-11-21/h5-9,12-13,20,22H,2-4,10-11H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267071
PNG
(Methyl 4-[(biphenyl-3-ylsulfonyl)amino]-2-hydroxyb...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccccc2)cc1O
Show InChI InChI=1S/C20H17NO5S/c1-26-20(23)18-11-10-16(13-19(18)22)21-27(24,25)17-9-5-8-15(12-17)14-6-3-2-4-7-14/h2-13,21-22H,1H3
PDB

UniProtKB/SwissProt

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PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267024
PNG
(Methyl 4-({[3-(2,3-dihydro-1-benzofuran-5-yl)-5-(t...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)-c2ccc3OCCc3c2)cc1O
Show InChI InChI=1S/C23H18F3NO6S/c1-32-22(29)19-4-3-17(12-20(19)28)27-34(30,31)18-10-15(9-16(11-18)23(24,25)26)13-2-5-21-14(8-13)6-7-33-21/h2-5,8-12,27-28H,6-7H2,1H3
PDB

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n/an/a 1.70E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267077
PNG
(Methyl 4-({[3-(5-acetyl-2-thienyl)phenyl]sulfonyl}...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc(s2)C(C)=O)cc1O
Show InChI InChI=1S/C20H17NO6S2/c1-12(22)18-8-9-19(28-18)13-4-3-5-15(10-13)29(25,26)21-14-6-7-16(17(23)11-14)20(24)27-2/h3-11,21,23H,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267025
PNG
(4-{[(4-Bromo-2,5-dichlorothiophen-3-yl)sulfonyl]am...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Br)cc1O
Show InChI InChI=1S/C11H6BrCl2NO5S2/c12-7-8(10(14)21-9(7)13)22(19,20)15-4-1-2-5(11(17)18)6(16)3-4/h1-3,15-16H,(H,17,18)
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267070
PNG
(1-Benzylpyrrolidin-3-yl 2-hydroxy-4-{[(2,4,5-trich...)
Show SMILES Oc1cc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Cl)ccc1C(=O)OC1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C22H19Cl3N2O5S2/c23-18-19(21(25)33-20(18)24)34(30,31)26-14-6-7-16(17(28)10-14)22(29)32-15-8-9-27(12-15)11-13-4-2-1-3-5-13/h1-7,10,15,26,28H,8-9,11-12H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267021
PNG
(Methyl 4-[(tert-butoxycarbonyl)amino]-2-hydroxyben...)
Show SMILES COC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1O
Show InChI InChI=1S/C13H17NO5/c1-13(2,3)19-12(17)14-8-5-6-9(10(15)7-8)11(16)18-4/h5-7,15H,1-4H3,(H,14,17)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267080
PNG
(General Procedure 14 | US9718809, 230)
Show SMILES Oc1ccc(F)cc1-c1cccc(c1)S(=O)(=O)Nc1ccc(C(=O)OCCCNc2cccnc2)c(O)c1
Show InChI InChI=1S/C27H24FN3O6S/c28-19-7-10-25(32)24(15-19)18-4-1-6-22(14-18)38(35,36)31-20-8-9-23(26(33)16-20)27(34)37-13-3-12-30-21-5-2-11-29-17-21/h1-2,4-11,14-17,30-33H,3,12-13H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267049
PNG
(Methyl 4-({[5-chloro-4-(5-fluoro-2-hydroxyphenyl)-...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cc(F)ccc2O)cc1O
Show InChI InChI=1S/C18H13ClFNO6S2/c1-27-18(24)11-4-3-10(7-15(11)23)21-29(25,26)16-8-13(17(19)28-16)12-6-9(20)2-5-14(12)22/h2-8,21-23H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267026
PNG
(Methyl 4-({[5-(2,5-difluorophenyl)thiophen-2-yl]su...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2ccc(s2)-c2cc(F)ccc2F)cc1O
Show InChI InChI=1S/C18H13F2NO5S2/c1-26-18(23)12-4-3-11(9-15(12)22)21-28(24,25)17-7-6-16(27-17)13-8-10(19)2-5-14(13)20/h2-9,21-22H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267078
PNG
(2-Methoxy-1-(methoxymethyl)ethyl 4-({[5-chloro-4-(...)
Show SMILES COCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(F)c2)cc1O
Show InChI InChI=1S/C22H21ClFNO7S2/c1-30-11-16(12-31-2)32-22(27)17-7-6-15(9-19(17)26)25-34(28,29)20-10-18(21(23)33-20)13-4-3-5-14(24)8-13/h3-10,16,25-26H,11-12H2,1-2H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267038
PNG
(Methyl 4-({[5-(dimethylamino)naphthalen-1-yl]sulfo...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1O
Show InChI InChI=1S/C20H20N2O5S/c1-22(2)17-8-4-7-15-14(17)6-5-9-19(15)28(25,26)21-13-10-11-16(18(23)12-13)20(24)27-3/h4-12,21,23H,1-3H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267029
PNG
(Methyl 4-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1O
Show InChI InChI=1S/C12H9Cl2NO5S2/c1-20-12(17)7-3-2-6(4-8(7)16)15-22(18,19)9-5-10(13)21-11(9)14/h2-5,15-16H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267079
PNG
(Methyl 2-hydroxy-4-({[4'-(trifluoromethoxy)bipheny...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc(OC(F)(F)F)cc2)cc1O
Show InChI InChI=1S/C21H16F3NO6S/c1-30-20(27)18-10-7-15(12-19(18)26)25-32(28,29)17-4-2-3-14(11-17)13-5-8-16(9-6-13)31-21(22,23)24/h2-12,25-26H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267041
PNG
(Methyl 4-[({5-chloro-4-[3-(dimethylcarbamoyl)pheny...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(c2)C(=O)N(C)C)cc1O
Show InChI InChI=1S/C21H19ClN2O6S2/c1-24(2)20(26)13-6-4-5-12(9-13)16-11-18(31-19(16)22)32(28,29)23-14-7-8-15(17(25)10-14)21(27)30-3/h4-11,23,25H,1-3H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267057
PNG
(2-Hydroxyethyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3...)
Show SMILES OCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O
Show InChI InChI=1S/C21H18FNO7S/c22-14-4-7-19(25)18(11-14)13-2-1-3-16(10-13)31(28,29)23-15-5-6-17(20(26)12-15)21(27)30-9-8-24/h1-7,10-12,23-26H,8-9H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267016
PNG
(Methyl 4-({[4-(3-aminophenyl)-5-chlorothiophen-2-y...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(N)c2)cc1O
Show InChI InChI=1S/C18H15ClN2O5S2/c1-26-18(23)13-6-5-12(8-15(13)22)21-28(24,25)16-9-14(17(19)27-16)10-3-2-4-11(20)7-10/h2-9,21-22H,20H2,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267047
PNG
(General Procedure 10 | US9718809, 156)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C18H14ClNO6S2/c1-26-18(23)12-7-6-10(8-15(12)22)20-28(24,25)16-9-13(17(19)27-16)11-4-2-3-5-14(11)21/h2-9,20-22H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267051
PNG
(3-Morpholin-4-ylpropyl 4-({[4-(1,3-benzodioxol-5-y...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccc3OCOc3c2)ccc1C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C25H25ClN2O8S2/c26-24-19(16-2-5-21-22(12-16)36-15-35-21)14-23(37-24)38(31,32)27-17-3-4-18(20(29)13-17)25(30)34-9-1-6-28-7-10-33-11-8-28/h2-5,12-14,27,29H,1,6-11,15H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267048
PNG
(General Procedure 5 | US9718809, 53)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2C)cc1O
Show InChI InChI=1S/C13H11Cl2NO5S2/c1-6-10(12(15)22-11(6)14)23(19,20)16-7-3-4-8(9(17)5-7)13(18)21-2/h3-5,16-17H,1-2H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267067
PNG
(2-Methoxyethyl 4-{[(4-bromo-2,5-dichlorothiophen-3...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Br)cc1O
Show InChI InChI=1S/C14H12BrCl2NO6S2/c1-23-4-5-24-14(20)8-3-2-7(6-9(8)19)18-26(21,22)11-10(15)12(16)25-13(11)17/h2-3,6,18-19H,4-5H2,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267094
PNG
(3-Morpholin-4-ylpropyl 4-{[(5'-fluoro-2'-hydroxybi...)
Show SMILES Oc1ccc(F)cc1-c1cccc(c1)S(=O)(=O)Nc1ccc(C(=O)OCCCN2CCOCC2)c(O)c1
Show InChI InChI=1S/C26H27FN2O7S/c27-19-5-8-24(30)23(16-19)18-3-1-4-21(15-18)37(33,34)28-20-6-7-22(25(31)17-20)26(32)36-12-2-9-29-10-13-35-14-11-29/h1,3-8,15-17,28,30-31H,2,9-14H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267036
PNG
(Methyl 4-{[(4-fluoro-1-naphthyl)sulfonyl]amino}-2-...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2ccc(F)c3ccccc23)cc1O
Show InChI InChI=1S/C18H14FNO5S/c1-25-18(22)14-7-6-11(10-16(14)21)20-26(23,24)17-9-8-15(19)12-4-2-3-5-13(12)17/h2-10,20-21H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267056
PNG
(3-Morpholin-4-ylpropyl 4-{[(4,5-dichlorothiophen-2...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)ccc1C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C18H20Cl2N2O6S2/c19-14-11-16(29-17(14)20)30(25,26)21-12-2-3-13(15(23)10-12)18(24)28-7-1-4-22-5-8-27-9-6-22/h2-3,10-11,21,23H,1,4-9H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267075
PNG
(Methyl 2-hydroxy-4-{[(3-quinolin-6-ylphenyl)sulfon...)
Show SMILES OC(=O)C(F)(F)F.COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc3ncccc3c2)cc1O
Show InChI InChI=1S/C23H18N2O5S.C2HF3O2/c1-30-23(27)20-9-8-18(14-22(20)26)25-31(28,29)19-6-2-4-15(13-19)16-7-10-21-17(12-16)5-3-11-24-21;3-2(4,5)1(6)7/h2-14,25-26H,1H3;(H,6,7)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267020
PNG
(Methyl 4-{[(5-chloro-4-pyridin-3-ylthiophen-2-yl)s...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccnc2)cc1O
Show InChI InChI=1S/C17H13ClN2O5S2/c1-25-17(22)12-5-4-11(7-14(12)21)20-27(23,24)15-8-13(16(18)26-15)10-3-2-6-19-9-10/h2-9,20-21H,1H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267023
PNG
(Methyl 2-hydroxy-4-({[4-(trifluoromethyl)phenyl]su...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1O
Show InChI InChI=1S/C15H12F3NO5S/c1-24-14(21)12-7-4-10(8-13(12)20)19-25(22,23)11-5-2-9(3-6-11)15(16,17)18/h2-8,19-20H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267034
PNG
(Methyl 4-{[(3-chloro-4-fluorophenyl)sulfonyl]amino...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2ccc(F)c(Cl)c2)cc1O
Show InChI InChI=1S/C14H11ClFNO5S/c1-22-14(19)10-4-2-8(6-13(10)18)17-23(20,21)9-3-5-12(16)11(15)7-9/h2-7,17-18H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267045
PNG
(Methyl 4-({[6-chloro-5-(2,3-dihydro-1-benzofuran-5...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cnc(Cl)c(c2)-c2ccc3OCCc3c2)cc1O
Show InChI InChI=1S/C21H17ClN2O6S/c1-29-21(26)16-4-3-14(9-18(16)25)24-31(27,28)15-10-17(20(22)23-11-15)12-2-5-19-13(8-12)6-7-30-19/h2-5,8-11,24-25H,6-7H2,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267043
PNG
(Methyl 4-{[(2',5'-difluorobiphenyl-3-yl)sulfonyl]a...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2F)cc1O
Show InChI InChI=1S/C20H15F2NO5S/c1-28-20(25)16-7-6-14(11-19(16)24)23-29(26,27)15-4-2-3-12(9-15)17-10-13(21)5-8-18(17)22/h2-11,23-24H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267060
PNG
(Tetrahydrofuran-3-yl 4-{[(2,5-dichloro-3-thienyl)s...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)sc2Cl)ccc1C(=O)OC1CCOC1
Show InChI InChI=1S/C15H13Cl2NO6S2/c16-13-6-12(14(17)25-13)26(21,22)18-8-1-2-10(11(19)5-8)15(20)24-9-3-4-23-7-9/h1-2,5-6,9,18-19H,3-4,7H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267053
PNG
(3-Morpholin-4-ylpropyl 2-hydroxy-4-{[(2,4,5-trichl...)
Show SMILES Oc1cc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Cl)ccc1C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C18H19Cl3N2O6S2/c19-14-15(17(21)30-16(14)20)31(26,27)22-11-2-3-12(13(24)10-11)18(25)29-7-1-4-23-5-8-28-9-6-23/h2-3,10,22,24H,1,4-9H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267022
PNG
(Methyl 4-{[(3'-carbamoylbiphenyl-3-yl)sulfonyl]ami...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cccc(c2)C(N)=O)cc1O
Show InChI InChI=1S/C21H18N2O6S/c1-29-21(26)18-9-8-16(12-19(18)24)23-30(27,28)17-7-3-5-14(11-17)13-4-2-6-15(10-13)20(22)25/h2-12,23-24H,1H3,(H2,22,25)
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267069
PNG
((1-Methyl-2-nitro-1H-imidazol-5-yl)methyl 4-{[(4,5...)
Show SMILES Cn1c(COC(=O)c2ccc(NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc2O)cnc1[N+]([O-])=O
Show InChI InChI=1S/C16H12Cl2N4O7S2/c1-21-9(6-19-16(21)22(25)26)7-29-15(24)10-3-2-8(4-12(10)23)20-31(27,28)13-5-11(17)14(18)30-13/h2-6,20,23H,7H2,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267052
PNG
(Methyl 4-{[(5-bromo-4-methylthiophen-2-yl)sulfonyl...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(C)c(Br)s2)cc1O
Show InChI InChI=1S/C13H12BrNO5S2/c1-7-5-11(21-12(7)14)22(18,19)15-8-3-4-9(10(16)6-8)13(17)20-2/h3-6,15-16H,1-2H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267058
PNG
(2-Ethoxyethyl 4-{[(2,5-dichloro-3-thienyl)sulfonyl...)
Show SMILES CCOCCOC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1O
Show InChI InChI=1S/C15H15Cl2NO6S2/c1-2-23-5-6-24-15(20)10-4-3-9(7-11(10)19)18-26(21,22)12-8-13(16)25-14(12)17/h3-4,7-8,18-19H,2,5-6H2,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267050
PNG
(Methyl 4-{[(3,4-dibromothiophen-2-yl)sulfonyl]amin...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2scc(Br)c2Br)cc1O
Show InChI InChI=1S/C12H9Br2NO5S2/c1-20-11(17)7-3-2-6(4-9(7)16)15-22(18,19)12-10(14)8(13)5-21-12/h2-5,15-16H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267044
PNG
(Methyl 4-{[(5-bromo-2,4-difluorophenyl)sulfonyl]am...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Br)c(F)cc2F)cc1O
Show InChI InChI=1S/C14H10BrF2NO5S/c1-23-14(20)8-3-2-7(4-12(8)19)18-24(21,22)13-5-9(15)10(16)6-11(13)17/h2-6,18-19H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267042
PNG
(Methyl 2-hydroxy-4-({[3-(trifluoromethoxy)phenyl]s...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1O
Show InChI InChI=1S/C15H12F3NO6S/c1-24-14(21)12-6-5-9(7-13(12)20)19-26(22,23)11-4-2-3-10(8-11)25-15(16,17)18/h2-8,19-20H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267028
PNG
(Methyl 4-({[3-(2,3-dihydro-1-benzofuran-5-yl)benzy...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)Cc2cccc(c2)-c2ccc3OCCc3c2)cc1O
Show InChI InChI=1S/C23H21NO6S/c1-29-23(26)20-7-6-19(13-21(20)25)24-31(27,28)14-15-3-2-4-16(11-15)17-5-8-22-18(12-17)9-10-30-22/h2-8,11-13,24-25H,9-10,14H2,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267068
PNG
(General Procedure 9 | US9718809, 82)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C20H17NO6S/c1-27-20(24)17-10-9-14(12-19(17)23)21-28(25,26)15-6-4-5-13(11-15)16-7-2-3-8-18(16)22/h2-12,21-23H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267095
PNG
(2-Methoxybutyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3...)
Show SMILES CCC(COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O)OC
Show InChI InChI=1S/C24H24FNO7S/c1-3-18(32-2)14-33-24(29)20-9-8-17(13-23(20)28)26-34(30,31)19-6-4-5-15(11-19)21-12-16(25)7-10-22(21)27/h4-13,18,26-28H,3,14H2,1-2H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267073
PNG
(Methyl 2-hydroxy-4-{[(3-pyridin-4-ylphenyl)sulfony...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccncc2)cc1O
Show InChI InChI=1S/C19H16N2O5S/c1-26-19(23)17-6-5-15(12-18(17)22)21-27(24,25)16-4-2-3-14(11-16)13-7-9-20-10-8-13/h2-12,21-22H,1H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267019
PNG
(Methyl 2-hydroxy-4-({[2-methyl-5-(trifluoromethyl)...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(oc2C)C(F)(F)F)cc1O
Show InChI InChI=1S/C14H12F3NO6S/c1-7-11(6-12(24-7)14(15,16)17)25(21,22)18-8-3-4-9(10(19)5-8)13(20)23-2/h3-6,18-19H,1-2H3
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267092
PNG
(2-Phenoxyethyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3...)
Show SMILES Oc1cc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)ccc1C(=O)OCCOc1ccccc1
Show InChI InChI=1S/C27H22FNO7S/c28-19-9-12-25(30)24(16-19)18-5-4-8-22(15-18)37(33,34)29-20-10-11-23(26(31)17-20)27(32)36-14-13-35-21-6-2-1-3-7-21/h1-12,15-17,29-31H,13-14H2
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Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267059
PNG
(3-Morpholin-4-ylpropyl 4-{[(3,5-dichlorophenyl)sul...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C20H22Cl2N2O6S/c21-14-10-15(22)12-17(11-14)31(27,28)23-16-2-3-18(19(25)13-16)20(26)30-7-1-4-24-5-8-29-9-6-24/h2-3,10-13,23,25H,1,4-9H2
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n/an/a 6.80E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267018
PNG
(Methyl 4-{[(5-chloro-4-{4-[(methylsulfonyl)amino]p...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccc(NS(C)(=O)=O)cc2)cc1O
Show InChI InChI=1S/C19H17ClN2O7S3/c1-29-19(24)14-8-7-13(9-16(14)23)22-32(27,28)17-10-15(18(20)30-17)11-3-5-12(6-4-11)21-31(2,25)26/h3-10,21-23H,1-2H3
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n/an/a 7.70E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267081
PNG
(Methyl 4-({[4'-(dimethylcarbamoyl)biphenyl-3-yl]su...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc(cc2)C(=O)N(C)C)cc1O
Show InChI InChI=1S/C23H22N2O6S/c1-25(2)22(27)16-9-7-15(8-10-16)17-5-4-6-19(13-17)32(29,30)24-18-11-12-20(21(26)14-18)23(28)31-3/h4-14,24,26H,1-3H3
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n/an/a 8.40E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267072
PNG
(Methyl 4-({[4-chloro-5-(2-hydroxyphenyl)thiophen-2...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(s2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C18H14ClNO6S2/c1-26-18(23)12-7-6-10(8-15(12)22)20-28(24,25)16-9-13(19)17(27-16)11-4-2-3-5-14(11)21/h2-9,20-22H,1H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267027
PNG
(Methyl 4-{[(4-bromobenzyl)sulfonyl]amino}-2-hydrox...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)Cc2ccc(Br)cc2)cc1O
Show InChI InChI=1S/C15H14BrNO5S/c1-22-15(19)13-7-6-12(8-14(13)18)17-23(20,21)9-10-2-4-11(16)5-3-10/h2-8,17-18H,9H2,1H3
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n/an/a 1.04E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267046
PNG
(Methyl 4-[(1-benzothien-3-ylsulfonyl)amino]-2-hydr...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2csc3ccccc23)cc1O
Show InChI InChI=1S/C16H13NO5S2/c1-22-16(19)11-7-6-10(8-13(11)18)17-24(20,21)15-9-23-14-5-3-2-4-12(14)15/h2-9,17-18H,1H3
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n/an/a 1.08E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267037
PNG
(Methyl 2-hydroxy-4-[({3-[(1-methylethoxy)carbonyl]...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)C(=O)OC(C)C)cc1O
Show InChI InChI=1S/C18H19NO7S/c1-11(2)26-17(21)12-5-4-6-14(9-12)27(23,24)19-13-7-8-15(16(20)10-13)18(22)25-3/h4-11,19-20H,1-3H3
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n/an/a 1.11E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267033
PNG
(Methyl 2-(acetyloxy)-4-{[(4,5-dichlorothiophen-2-y...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1OC(C)=O
Show InChI InChI=1S/C14H11Cl2NO6S2/c1-7(18)23-11-5-8(3-4-9(11)14(19)22-2)17-25(20,21)12-6-10(15)13(16)24-12/h3-6,17H,1-2H3
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n/an/a 1.18E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267015
PNG
(Methyl 4-({[3-bromo-5-(trifluoromethyl)phenyl]sulf...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Br)cc(c2)C(F)(F)F)cc1O
Show InChI InChI=1S/C15H11BrF3NO5S/c1-25-14(22)12-3-2-10(7-13(12)21)20-26(23,24)11-5-8(15(17,18)19)4-9(16)6-11/h2-7,20-21H,1H3
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n/an/a 1.23E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267088
PNG
(Methyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3-yl)sulf...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O
Show InChI InChI=1S/C20H16FNO6S/c1-28-20(25)16-7-6-14(11-19(16)24)22-29(26,27)15-4-2-3-12(9-15)17-10-13(21)5-8-18(17)23/h2-11,22-24H,1H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267032
PNG
(1-Methylethyl 3'-{[3-hydroxy-4-(methoxycarbonyl)ph...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cccc(c2)C(=O)OC(C)C)cc1O
Show InChI InChI=1S/C24H23NO7S/c1-15(2)32-23(27)18-8-4-6-16(12-18)17-7-5-9-20(13-17)33(29,30)25-19-10-11-21(22(26)14-19)24(28)31-3/h4-15,25-26H,1-3H3
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n/an/a 1.33E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267085
PNG
(Isopropyl 4-{[(4,5-dichloro-2-thienyl)sulfonyl]ami...)
Show SMILES CC(C)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
Show InChI InChI=1S/C14H13Cl2NO5S2/c1-7(2)22-14(19)9-4-3-8(5-11(9)18)17-24(20,21)12-6-10(15)13(16)23-12/h3-7,17-18H,1-2H3
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n/an/a 1.56E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267084
PNG
(2-Methoxyethyl 4-{[(2',5'-difluorobiphenyl-3-yl)su...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2F)cc1O
Show InChI InChI=1S/C22H19F2NO6S/c1-30-9-10-31-22(27)18-7-6-16(13-21(18)26)25-32(28,29)17-4-2-3-14(11-17)19-12-15(23)5-8-20(19)24/h2-8,11-13,25-26H,9-10H2,1H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267047
PNG
(General Procedure 10 | US9718809, 156)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C18H14ClNO6S2/c1-26-18(23)12-7-6-10(8-15(12)22)20-28(24,25)16-9-13(17(19)27-16)11-4-2-3-5-14(11)21/h2-9,20-22H,1H3
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n/an/a 1.61E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267086
PNG
(1-(Methoxymethyl)propyl 4-{[(3,5-dichlorophenyl)su...)
Show SMILES CCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1O
Show InChI InChI=1S/C18H19Cl2NO6S/c1-3-14(10-26-2)27-18(23)16-5-4-13(9-17(16)22)21-28(24,25)15-7-11(19)6-12(20)8-15/h4-9,14,21-22H,3,10H2,1-2H3
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n/an/a 1.64E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267096
PNG
(US9718809, 205 | tert-Butyl 3-[(2-hydroxy-4-{[(2,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(C1)OC(=O)c1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Cl)cc1O
Show InChI InChI=1S/C20H21Cl3N2O7S2/c1-20(2,3)32-19(28)25-7-6-11(9-25)31-18(27)12-5-4-10(8-13(12)26)24-34(29,30)15-14(21)16(22)33-17(15)23/h4-5,8,11,24,26H,6-7,9H2,1-3H3
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n/an/a 1.77E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267040
PNG
(Methyl 2-hydroxy-4-{[(5-{[(phenylcarbonyl)amino]me...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2ccc(CNC(=O)c3ccccc3)s2)cc1O
Show InChI InChI=1S/C20H18N2O6S2/c1-28-20(25)16-9-7-14(11-17(16)23)22-30(26,27)18-10-8-15(29-18)12-21-19(24)13-5-3-2-4-6-13/h2-11,22-23H,12H2,1H3,(H,21,24)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267017
PNG
(Methyl 4-[(1-benzofuran-2-ylsulfonyl)amino]-2-hydr...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc3ccccc3o2)cc1O
Show InChI InChI=1S/C16H13NO6S/c1-22-16(19)12-7-6-11(9-13(12)18)17-24(20,21)15-8-10-4-2-3-5-14(10)23-15/h2-9,17-18H,1H3
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n/an/a 1.96E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267089
PNG
(1-(Methoxymethyl)propyl 4-{[(4,5-dichlorothiophen-...)
Show SMILES CCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
Show InChI InChI=1S/C16H17Cl2NO6S2/c1-3-10(8-24-2)25-16(21)11-5-4-9(6-13(11)20)19-27(22,23)14-7-12(17)15(18)26-14/h4-7,10,19-20H,3,8H2,1-2H3
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n/an/a 2.04E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267090
PNG
(3-Morpholin-4-ylpropyl 4-{[(4-bromo-2,5-dichloroth...)
Show SMILES Oc1cc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Br)ccc1C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C18H19BrCl2N2O6S2/c19-14-15(17(21)30-16(14)20)31(26,27)22-11-2-3-12(13(24)10-11)18(25)29-7-1-4-23-5-8-28-9-6-23/h2-3,10,22,24H,1,4-9H2
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n/an/a 2.06E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267087
PNG
(2-Methoxy-1-methylethyl 4-{[(3,5-dichlorophenyl)su...)
Show SMILES COCC(C)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1O
Show InChI InChI=1S/C17H17Cl2NO6S/c1-10(9-25-2)26-17(22)15-4-3-13(8-16(15)21)20-27(23,24)14-6-11(18)5-12(19)7-14/h3-8,10,20-21H,9H2,1-2H3
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n/an/a 2.23E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267083
PNG
(Methyl 4-({[5-chloro-4-(2,5-difluorophenyl)-2-thie...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cc(F)ccc2F)cc1O
Show InChI InChI=1S/C18H12ClF2NO5S2/c1-27-18(24)11-4-3-10(7-15(11)23)22-29(25,26)16-8-13(17(19)28-16)12-6-9(20)2-5-14(12)21/h2-8,22-23H,1H3
PDB

UniProtKB/SwissProt

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PubMed
n/an/a 2.25E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267093
PNG
(Tetrahydrofuran-3-ylmethyl 4-{[(4,5-dichloro-2-thi...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)ccc1C(=O)OCC1CCOC1
Show InChI InChI=1S/C16H15Cl2NO6S2/c17-12-6-14(26-15(12)18)27(22,23)19-10-1-2-11(13(20)5-10)16(21)25-8-9-3-4-24-7-9/h1-2,5-6,9,19-20H,3-4,7-8H2
PDB

UniProtKB/SwissProt

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n/an/a 2.53E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267091
PNG
(3-Morpholin-4-ylpropyl 4-({[5-chloro-4-(2,3-dihydr...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccc3OCCc3c2)ccc1C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C26H27ClN2O7S2/c27-25-21(17-2-5-23-18(14-17)6-11-35-23)16-24(37-25)38(32,33)28-19-3-4-20(22(30)15-19)26(31)36-10-1-7-29-8-12-34-13-9-29/h2-5,14-16,28,30H,1,6-13H2
PDB

UniProtKB/SwissProt

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PubMed
n/an/a 3.02E+4n/an/an/an/an/an/a



Kancera AB

US Patent


Assay Description
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...


US Patent US9718809 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%