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Patent code US9718819

Compile Data Set for Download or QSAR
Found 182 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267390
PNG
(3-chloro-5-((1-((5-(4- fluorophenyl)-6-oxo- 1,6-di...)
Show SMILES FC(F)Oc1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H13ClF3N5O4/c24-14-5-12(9-28)6-17(7-14)35-19-21(36-23(26)27)29-11-32(22(19)34)10-16-8-18(20(33)31-30-16)13-1-3-15(25)4-2-13/h1-8,11,23H,10H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267287
PNG
(3-chloro-5-((1-((5- (2,3- dihydrobenzofuran-5- yl)...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccc4OCCc4c3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C25H15ClF3N5O4/c26-16-5-13(10-30)6-18(8-16)38-21-22(25(27,28)29)31-12-34(24(21)36)11-17-9-19(23(35)33-32-17)14-1-2-20-15(7-14)3-4-37-20/h1-2,5-9,12H,3-4,11H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267334
PNG
(3-chloro-5-((6-oxo-1-((3-oxo-6-phenyl-2,3-dihydrop...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)-c2ccccc2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H13ClF3N5O3/c24-16-6-13(10-28)7-17(9-16)35-19-20(23(25,26)27)29-12-32(22(19)34)11-15-8-18(30-31-21(15)33)14-4-2-1-3-5-14/h1-9,12H,11H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267344
PNG
(3-chloro-5-((1-((6- (2,3- difluorophenyl)-3- oxo-2...)
Show SMILES Fc1cccc(c1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C23H11ClF5N5O3/c24-13-4-11(8-30)5-14(7-13)37-19-20(23(27,28)29)31-10-34(22(19)36)9-12-6-17(32-33-21(12)35)15-2-1-3-16(25)18(15)26/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267399
PNG
(3-chloro-5-((4-(1,1- difluoroethyl)-1-((6- (difluo...)
Show SMILES CC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)C(F)F)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C19H12ClF4N5O3/c1-19(23,24)15-14(32-12-3-9(6-25)2-11(20)5-12)18(31)29(8-26-15)7-10-4-13(16(21)22)27-28-17(10)30/h2-5,8,16H,7H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267389
PNG
(2-fluoro-3-((1-((5-(4-fluorophenyl)-6-oxo-1,6-dihy...)
Show SMILES Fc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cccc(C#N)c3F)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H12F5N5O3/c24-14-6-4-12(5-7-14)16-8-15(31-32-21(16)34)10-33-11-30-20(23(26,27)28)19(22(33)35)36-17-3-1-2-13(9-29)18(17)25/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267395
PNG
(3-((4-(1,1-difluoroethyl)-1-((5-(4-fluorophenyl)-6...)
Show SMILES CC(F)(F)c1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cccc(C#N)c1F
Show InChI InChI=1S/C24H15F4N5O3/c1-24(27,28)21-20(36-18-4-2-3-14(10-29)19(18)26)23(35)33(12-30-21)11-16-9-17(22(34)32-31-16)13-5-7-15(25)8-6-13/h2-9,12H,11H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267245
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-5-phenyl-1,6-dihydrop...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccccc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H13ClF3N5O3/c24-15-6-13(10-28)7-17(8-15)35-19-20(23(25,26)27)29-12-32(22(19)34)11-16-9-18(21(33)31-30-16)14-4-2-1-3-5-14/h1-9,12H,11H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267252
PNG
(3-chloro-5-((1-((5- (3,4-difluorophenyl)- 6-oxo-1,...)
Show SMILES Fc1ccc(cc1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11ClF5N5O3/c24-13-3-11(8-30)4-15(6-13)37-19-20(23(27,28)29)31-10-34(22(19)36)9-14-7-16(21(35)33-32-14)12-1-2-17(25)18(26)5-12/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267259
PNG
(3-chloro-5-((1-((5-(3- chlorophenyl)-6-oxo- 1,6-di...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3cccc(Cl)c3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H12Cl2F3N5O3/c24-14-3-1-2-13(6-14)18-8-16(31-32-21(18)34)10-33-11-30-20(23(26,27)28)19(22(33)35)36-17-5-12(9-29)4-15(25)7-17/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267267
PNG
(3-chloro-5-((1-((5-(2- fluoro-3- methoxyphenyl)-6-...)
Show SMILES COc1cccc(c1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O4/c1-37-18-4-2-3-16(19(18)26)17-8-14(32-33-22(17)35)10-34-11-31-21(24(27,28)29)20(23(34)36)38-15-6-12(9-30)5-13(25)7-15/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267253
PNG
(3-chloro-5-((1-((5-(4- (difluoromethoxy) phenyl)-6...)
Show SMILES FC(F)Oc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H13ClF5N5O4/c25-14-5-12(9-31)6-17(7-14)38-19-20(24(28,29)30)32-11-35(22(19)37)10-15-8-18(21(36)34-33-15)13-1-3-16(4-2-13)39-23(26)27/h1-8,11,23H,10H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267393
PNG
(3-chloro-5-((1-((5-(4-fluorophenyl)-6-oxo-1,6-dihy...)
Show SMILES Cc1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H15ClFN5O3/c1-13-21(33-19-7-14(10-26)6-16(24)8-19)23(32)30(12-27-13)11-18-9-20(22(31)29-28-18)15-2-4-17(25)5-3-15/h2-9,12H,11H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267275
PNG
(3-chloro-5-((1-((5-(3- fluoro-4- methoxyphenyl)-6-...)
Show SMILES COc1ccc(cc1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O4/c1-37-19-3-2-13(6-18(19)26)17-8-15(32-33-22(17)35)10-34-11-31-21(24(27,28)29)20(23(34)36)38-16-5-12(9-30)4-14(25)7-16/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267281
PNG
(3-chloro-5-((1-((5-(3- fluoro-4- methylphenyl)-6-o...)
Show SMILES Cc1ccc(cc1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O3/c1-12-2-3-14(6-19(12)26)18-8-16(32-33-22(18)35)10-34-11-31-21(24(27,28)29)20(23(34)36)37-17-5-13(9-30)4-15(25)7-17/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267300
PNG
(3-chloro-5-((1-((5-(4-fluorophenyl)-6-oxo-1,6-dihy...)
Show SMILES Fc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H12ClF4N5O3/c24-14-5-12(9-29)6-17(7-14)36-19-20(23(26,27)28)30-11-33(22(19)35)10-16-8-18(21(34)32-31-16)13-1-3-15(25)4-2-13/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267350
PNG
(3-chloro-5-((6-oxo- 1-((3-oxo-6-(1H- pyrrolo[2,3- ...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)-c2ccnc3[nH]ccc23)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H11ClF3N7O3/c25-14-5-12(9-29)6-15(8-14)38-19-20(24(26,27)28)32-11-35(23(19)37)10-13-7-18(33-34-22(13)36)16-1-3-30-21-17(16)2-4-31-21/h1-8,11H,10H2/b18-16+
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267352
PNG
(3-chloro-5-((1-((6-(difluoromethyl)-3-oxo-2,3-dihy...)
Show SMILES FC(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C18H9ClF5N5O3/c19-10-1-8(5-25)2-11(4-10)32-13-14(18(22,23)24)26-7-29(17(13)31)6-9-3-12(15(20)21)27-28-16(9)30/h1-4,7,15H,6H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267288
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(1H- pyrazol-5-yl)...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccn[nH]3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H9ClF3N7O3/c21-11-3-10(7-25)4-13(5-11)34-16-17(20(22,23)24)26-9-31(19(16)33)8-12-6-14(18(32)30-28-12)15-1-2-27-29-15/h1-6,9H,8H2/b15-14-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267396
PNG
(3-chloro-5-((1-((6-(difluoromethyl)-3-oxo-2,3-dihy...)
Show SMILES FC(F)c1cc(Cn2ccc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C19H10ClF5N4O3/c20-11-3-9(7-26)4-12(6-11)32-15-13(19(23,24)25)1-2-29(18(15)31)8-10-5-14(16(21)22)27-28-17(10)30/h1-6,16H,8H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267251
PNG
(3-chloro-5-((1-((5-(4- chlorophenyl)-6-oxo- 1,6-di...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccc(Cl)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H12Cl2F3N5O3/c24-14-3-1-13(2-4-14)18-8-16(31-32-21(18)34)10-33-11-30-20(23(26,27)28)19(22(33)35)36-17-6-12(9-29)5-15(25)7-17/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267260
PNG
(3-chloro-5-((1-((5-(4- fluoro-3- methylphenyl)-6-o...)
Show SMILES Cc1cc(ccc1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O3/c1-12-4-14(2-3-19(12)26)18-8-16(32-33-22(18)35)10-34-11-31-21(24(27,28)29)20(23(34)36)37-17-6-13(9-30)5-15(25)7-17/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267294
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(1H- pyrazol-4-yl)...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3cn[nH]c3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H9ClF3N7O3/c21-12-1-10(5-25)2-14(3-12)34-16-17(20(22,23)24)26-9-31(19(16)33)8-13-4-15(18(32)30-29-13)11-6-27-28-7-11/h1-4,6-7,9H,8H2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267336
PNG
(3-chloro-5-((1-((6- (4-fluorophenyl)-3- oxo-2,3- d...)
Show SMILES Fc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C23H12ClF4N5O3/c24-15-5-12(9-29)6-17(8-15)36-19-20(23(26,27)28)30-11-33(22(19)35)10-14-7-18(31-32-21(14)34)13-1-3-16(25)4-2-13/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267345
PNG
(3-chloro-5-((1-((6- (3,4- difluorophenyl)-3- oxo-2...)
Show SMILES Fc1ccc(cc1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C23H11ClF5N5O3/c24-14-3-11(8-30)4-15(7-14)37-19-20(23(27,28)29)31-10-34(22(19)36)9-13-6-18(32-33-21(13)35)12-1-2-16(25)17(26)5-12/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267398
PNG
(3-((1-((6- (difluoromethyl)-3- oxo-2,3- dihydropyr...)
Show SMILES FC(F)c1cc(Cn2cnc(c(Oc3cccc([N+]#[C-])c3F)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C18H9F6N5O3/c1-25-9-3-2-4-11(12(9)19)32-13-14(18(22,23)24)26-7-29(17(13)31)6-8-5-10(15(20)21)27-28-16(8)30/h2-5,7,15H,6H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267241
PNG
(2,5-dichloro-3-((6-oxo-1-((6-oxo-1,6-dihydropyrida...)
Show SMILES FC(F)(F)c1ncn(Cc2ccc(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(C#N)c1Cl
Show InChI InChI=1S/C17H8Cl2F3N5O3/c18-9-3-8(5-23)13(19)11(4-9)30-14-15(17(20,21)22)24-7-27(16(14)29)6-10-1-2-12(28)26-25-10/h1-4,7H,6H2,(H,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267269
PNG
(3-chloro-5-((1-((5-(4- chloro-3- fluorophenyl)-6-o...)
Show SMILES Fc1cc(ccc1Cl)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-13-3-11(8-30)4-15(6-13)37-19-20(23(27,28)29)31-10-34(22(19)36)9-14-7-16(21(35)33-32-14)12-1-2-17(25)18(26)5-12/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267394
PNG
(3-chloro-5-((4-(1,1-difluoroethyl)-1-((5-(4-fluoro...)
Show SMILES CC(F)(F)c1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H15ClF3N5O3/c1-24(27,28)21-20(36-18-7-13(10-29)6-15(25)8-18)23(35)33(12-30-21)11-17-9-19(22(34)32-31-17)14-2-4-16(26)5-3-14/h2-9,12H,11H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267249
PNG
(3-chloro-5-((1-((5(3- fluorophenyl)-6-oxo- 1,6-dih...)
Show SMILES Fc1cccc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H12ClF4N5O3/c24-14-4-12(9-29)5-17(7-14)36-19-20(23(26,27)28)30-11-33(22(19)35)10-16-8-18(21(34)32-31-16)13-2-1-3-15(25)6-13/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267392
PNG
(5-fluoro-3-((1-((5-(4- fluorophenyl)-6-oxo- 1,6-di...)
Show SMILES Cc1c(Oc2c(ncn(Cc3cc(-c4ccc(F)cc4)c(=O)[nH]n3)c2=O)C(F)(F)F)cc(F)cc1[N+]#[C-]
Show InChI InChI=1S/C24H14F5N5O3/c1-12-18(30-2)7-15(26)8-19(12)37-20-21(24(27,28)29)31-11-34(23(20)36)10-16-9-17(22(35)33-32-16)13-3-5-14(25)6-4-13/h3-9,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267254
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(p-tolyl)- 1,6-dih...)
Show SMILES Cc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H15ClF3N5O3/c1-13-2-4-15(5-3-13)19-9-17(31-32-22(19)34)11-33-12-30-21(24(26,27)28)20(23(33)35)36-18-7-14(10-29)6-16(25)8-18/h2-9,12H,11H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267404
PNG
(3-chloro-5-((4-(1,1- difluoroethyl)-1-((6- (1,1-di...)
Show SMILES CC(F)(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(C)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C20H14ClF4N5O3/c1-19(22,23)14-5-11(17(31)29-28-14)8-30-9-27-16(20(2,24)25)15(18(30)32)33-13-4-10(7-26)3-12(21)6-13/h3-6,9H,8H2,1-2H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267315
PNG
(3-chloro-5-((1-((5-(dimethylamino)-6-oxo-1,6-dihyd...)
Show SMILES CN(C)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C19H14ClF3N6O3/c1-28(2)14-6-12(26-27-17(14)30)8-29-9-25-16(19(21,22)23)15(18(29)31)32-13-4-10(7-24)3-11(20)5-13/h3-6,9H,8H2,1-2H3,(H,27,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267397
PNG
(3-chloro-5-((4- (difluoromethyl)-1-((6- (difluorom...)
Show SMILES FC(F)c1cc(Cn2cnc(C(F)F)c(Oc3cc(Cl)cc(c3)C#N)c2=O)c(=O)[nH]n1
Show InChI InChI=1S/C18H10ClF4N5O3/c19-10-1-8(5-24)2-11(4-10)31-14-13(16(22)23)25-7-28(18(14)30)6-9-3-12(15(20)21)26-27-17(9)29/h1-4,7,15-16H,6H2,(H,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267347
PNG
(3-chloro-5-((1-((6- (4-chloro-3- fluorophenyl)-3- ...)
Show SMILES Fc1cc(ccc1Cl)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-14-3-11(8-30)4-15(7-14)37-19-20(23(27,28)29)31-10-34(22(19)36)9-13-6-18(32-33-21(13)35)12-1-2-16(25)17(26)5-12/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267348
PNG
(3-chloro-5-((6-oxo- 1-((3-oxo-6- (pyridin-3-yl)-2,...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)-c2cccnc2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C22H12ClF3N6O3/c23-15-4-12(8-27)5-16(7-15)35-18-19(22(24,25)26)29-11-32(21(18)34)10-14-6-17(30-31-20(14)33)13-2-1-3-28-9-13/h1-7,9,11H,10H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267400
PNG
(3-chloro-5-((1-((6- (difluoromethyl)-3- oxo-2,3- d...)
Show SMILES Cc1ncn(Cc2cc(n[nH]c2=O)C(F)F)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C18H12ClF2N5O3/c1-9-15(29-13-3-10(6-22)2-12(19)5-13)18(28)26(8-23-9)7-11-4-14(16(20)21)24-25-17(11)27/h2-5,8,16H,7H2,1H3,(H,25,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267314
PNG
(3-chloro-5-((1-((5-chloro-6-oxo-1,6-dihydropyridaz...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(Cl)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H8Cl2F3N5O3/c18-9-1-8(5-23)2-11(3-9)30-13-14(17(20,21)22)24-7-27(16(13)29)6-10-4-12(19)15(28)26-25-10/h1-4,7H,6H2,(H,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267391
PNG
(3-(difluoromethoxy)- 5-((1-((5-(4- fluorophenyl)-6...)
Show SMILES FC(F)Oc1cc(Oc2c(ncn(Cc3cc(-c4ccc(F)cc4)c(=O)[nH]n3)c2=O)C(F)(F)F)cc(c1)[N+]#[C-]
Show InChI InChI=1S/C24H13F6N5O4/c1-31-14-6-16(9-17(7-14)39-23(26)27)38-19-20(24(28,29)30)32-11-35(22(19)37)10-15-8-18(21(36)34-33-15)12-2-4-13(25)5-3-12/h2-9,11,23H,10H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267301
PNG
(3-chloro-5-((1-((5-(6-fluoropyridin-3-yl)-6-oxo-1,...)
Show SMILES Fc1ccc(cn1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C22H11ClF4N6O3/c23-13-3-11(7-28)4-15(5-13)36-18-19(22(25,26)27)30-10-33(21(18)35)9-14-6-16(20(34)32-31-14)12-1-2-17(24)29-8-12/h1-6,8,10H,9H2,(H,32,34)
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n/an/a 6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267353
PNG
(3-chloro-5-((1-((6-(1,1-difluoroethyl)-3-oxo-2,3-d...)
Show SMILES CC(F)(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C19H11ClF5N5O3/c1-18(21,22)13-4-10(16(31)29-28-13)7-30-8-27-15(19(23,24)25)14(17(30)32)33-12-3-9(6-26)2-11(20)5-12/h2-5,8H,7H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267346
PNG
(4-(5-((5-(3-chloro- 5-cyanophenoxy)- 6-oxo-4- (tri...)
Show SMILES Fc1cc(ccc1C#N)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C24H11ClF4N6O3/c25-16-3-12(8-30)4-17(7-16)38-20-21(24(27,28)29)32-11-35(23(20)37)10-15-6-19(33-34-22(15)36)13-1-2-14(9-31)18(26)5-13/h1-7,11H,10H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267228
PNG
(3-chloro-5-((6-oxo-1-((3-oxo-2,3-dihydropyridazin-...)
Show SMILES FC(F)(F)c1ncn(Cc2ccn[nH]c2=O)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H9ClF3N5O3/c18-11-3-9(6-22)4-12(5-11)29-13-14(17(19,20)21)23-8-26(16(13)28)7-10-1-2-24-25-15(10)27/h1-5,8H,7H2,(H,25,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267337
PNG
(3-chloro-5-((1-((6- (3-fluorophenyl)-3- oxo-2,3- d...)
Show SMILES Fc1cccc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C23H12ClF4N5O3/c24-15-4-12(9-29)5-17(8-15)36-19-20(23(26,27)28)30-11-33(22(19)35)10-14-7-18(31-32-21(14)34)13-2-1-3-16(25)6-13/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267268
PNG
(3-chloro-5-((1-((5-(2- fluoro-4- methoxyphenyl)-6-...)
Show SMILES COc1ccc(c(F)c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O4/c1-37-15-2-3-17(19(26)8-15)18-7-14(32-33-22(18)35)10-34-11-31-21(24(27,28)29)20(23(34)36)38-16-5-12(9-30)4-13(25)6-16/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267302
PNG
(3-chloro-5-((1-((5-(2- methoxypyridin-4-yl)-6- oxo...)
Show SMILES COc1cc(ccn1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H14ClF3N6O4/c1-36-18-6-13(2-3-29-18)17-8-15(31-32-21(17)34)10-33-11-30-20(23(25,26)27)19(22(33)35)37-16-5-12(9-28)4-14(24)7-16/h2-8,11H,10H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267313
PNG
(3-((1-((5-bromo-6-oxo- 1,6-dihydropyridazin-3- yl)...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(Br)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H8BrClF3N5O3/c18-12-4-10(25-26-15(12)28)6-27-7-24-14(17(20,21)22)13(16(27)29)30-11-2-8(5-23)1-9(19)3-11/h1-4,7H,6H2,(H,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267309
PNG
(3-chloro-5-((1-((5-(6- chloropyridin-3-yl)-6- oxo-...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccc(Cl)nc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C22H11Cl2F3N6O3/c23-13-3-11(7-28)4-15(5-13)36-18-19(22(25,26)27)30-10-33(21(18)35)9-14-6-16(20(34)32-31-14)12-1-2-17(24)29-8-12/h1-6,8,10H,9H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267341
PNG
(3-chloro-5-((1-((6- cyclopropyl-3-oxo- 2,3- dihydr...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)C2CC2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H13ClF3N5O3/c21-13-3-10(7-25)4-14(6-13)32-16-17(20(22,23)24)26-9-29(19(16)31)8-12-5-15(11-1-2-11)27-28-18(12)30/h3-6,9,11H,1-2,8H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267360
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-1,6-dihydropyrimidin-...)
Show SMILES FC(F)(F)c1ncn(Cc2cnc[nH]c2=O)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H9ClF3N5O3/c18-11-1-9(4-22)2-12(3-11)29-13-14(17(19,20)21)25-8-26(16(13)28)6-10-5-23-7-24-15(10)27/h1-3,5,7-8H,6H2,(H,23,24,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267305
PNG
(3-chloro-5-((1-((5-(5- fluoropyridin-3-yl)-6- oxo-...)
Show SMILES Fc1cncc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C22H11ClF4N6O3/c23-13-1-11(6-28)2-16(4-13)36-18-19(22(25,26)27)30-10-33(21(18)35)9-15-5-17(20(34)32-31-15)12-3-14(24)8-29-7-12/h1-5,7-8,10H,9H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267322
PNG
(3-chloro-5-((1-((5-(5-chloropyridin-2-yl)-6-oxo-1,...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccc(Cl)cn3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C22H11Cl2F3N6O3/c23-12-1-2-17(29-8-12)16-6-14(31-32-20(16)34)9-33-10-30-19(22(25,26)27)18(21(33)35)36-15-4-11(7-28)3-13(24)5-15/h1-6,8,10H,9H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267333
PNG
(3-chloro-5-((1-((5-(difluoromethoxy)-6-oxo-1,6-dih...)
Show SMILES FC(F)Oc1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C18H9ClF5N5O4/c19-9-1-8(5-25)2-11(3-9)32-13-14(18(22,23)24)26-7-29(16(13)31)6-10-4-12(33-17(20)21)15(30)28-27-10/h1-4,7,17H,6H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267295
PNG
(3-chloro-5-((1-((5-(1- methyl-1H-pyrazol-4- yl)-6-...)
Show SMILES Cn1cc(cn1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C21H13ClF3N7O3/c1-31-8-12(7-28-31)16-5-14(29-30-19(16)33)9-32-10-27-18(21(23,24)25)17(20(32)34)35-15-3-11(6-26)2-13(22)4-15/h2-5,7-8,10H,9H2,1H3,(H,30,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267367
PNG
(3-((1-((2-amino-6-oxo- 1,6-dihydropyrimidin-5- yl)...)
Show SMILES Nc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C17H10ClF3N6O3/c18-10-1-8(4-22)2-11(3-10)30-12-13(17(19,20)21)25-7-27(15(12)29)6-9-5-24-16(23)26-14(9)28/h1-3,5,7H,6H2,(H3,23,24,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267233
PNG
(3-chloro-5-((1-((5- isopropyl-6-oxo-1,6- dihydropy...)
Show SMILES CC(C)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C20H15ClF3N5O3/c1-10(2)15-6-13(27-28-18(15)30)8-29-9-26-17(20(22,23)24)16(19(29)31)32-14-4-11(7-25)3-12(21)5-14/h3-6,9-10H,8H2,1-2H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267342
PNG
(3-chloro-5-((6-oxo- 1-((3-oxo-6-(1H- pyrazol-4-yl)...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)-c2cn[nH]c2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H9ClF3N7O3/c21-13-1-10(5-25)2-14(4-13)34-16-17(20(22,23)24)26-9-31(19(16)33)8-11-3-15(29-30-18(11)32)12-6-27-28-7-12/h1-4,6-7,9H,8H2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267283
PNG
(3-chloro-5-((1-((5-(3- fluoro-5- methylphenyl)-6-o...)
Show SMILES Cc1cc(F)cc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O3/c1-12-2-14(6-16(26)3-12)19-8-17(32-33-22(19)35)10-34-11-31-21(24(27,28)29)20(23(34)36)37-18-5-13(9-30)4-15(25)7-18/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267289
PNG
(3-chloro-5-((1-((5- cyclopropyl-6-oxo- 1,6-dihydro...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(C3CC3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H13ClF3N5O3/c21-12-3-10(7-25)4-14(5-12)32-16-17(20(22,23)24)26-9-29(19(16)31)8-13-6-15(11-1-2-11)18(30)28-27-13/h3-6,9,11H,1-2,8H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267257
PNG
(3-chloro-5-((1-((5-(3- chloro-4- fluorophenyl)-6-o...)
Show SMILES Fc1ccc(cc1Cl)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-13-3-11(8-30)4-15(6-13)37-19-20(23(27,28)29)31-10-34(22(19)36)9-14-7-16(21(35)33-32-14)12-1-2-18(26)17(25)5-12/h1-7,10H,9H2,(H,33,35)
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n/an/a 7n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267291
PNG
(4-(6-((5-(3-chloro-5- cyanophenoxy)-6- oxo-4- (tri...)
Show SMILES Fc1cc(ccc1C#N)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H11ClF4N6O3/c25-15-3-12(8-30)4-17(6-15)38-20-21(24(27,28)29)32-11-35(23(20)37)10-16-7-18(22(36)34-33-16)13-1-2-14(9-31)19(26)5-13/h1-7,11H,10H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267338
PNG
(3-chloro-5-((1-((6- (1-methyl-1H- pyrazol-5-yl)-3-...)
Show SMILES Cn1nccc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C21H13ClF3N7O3/c1-31-16(2-3-28-31)15-6-12(19(33)30-29-15)9-32-10-27-18(21(23,24)25)17(20(32)34)35-14-5-11(8-26)4-13(22)7-14/h2-7,10H,9H2,1H3,(H,30,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267339
PNG
(3-chloro-5-((1-((6- (4- (difluoromethoxy) phenyl)-...)
Show SMILES FC(F)Oc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C24H13ClF5N5O4/c25-15-5-12(9-31)6-17(8-15)38-19-20(24(28,29)30)32-11-35(22(19)37)10-14-7-18(33-34-21(14)36)13-1-3-16(4-2-13)39-23(26)27/h1-8,11,23H,10H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267388
PNG
(5-fluoro-2-methyl-3-(6-oxo-1-((6-oxo-1,6-dihydropy...)
Show SMILES Cc1c(Oc2c(ncn(Cc3ccc(=O)[nH]n3)c2=O)C(F)(F)F)cc(F)cc1C#N
Show InChI InChI=1S/C18H11F4N5O3/c1-9-10(6-23)4-11(19)5-13(9)30-15-16(18(20,21)22)24-8-27(17(15)29)7-12-2-3-14(28)26-25-12/h2-5,8H,7H2,1H3,(H,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267256
PNG
(3-chloro-5-((1-((5- (3,5-difluorophenyl)- 6-oxo-1,...)
Show SMILES Fc1cc(F)cc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11ClF5N5O3/c24-13-1-11(8-30)2-17(5-13)37-19-20(23(27,28)29)31-10-34(22(19)36)9-16-7-18(21(35)33-32-16)12-3-14(25)6-15(26)4-12/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267265
PNG
(3-chloro-5-((1-((5-(2- fluoro-4- methylphenyl)-6-o...)
Show SMILES Cc1ccc(c(F)c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O3/c1-12-2-3-17(19(26)4-12)18-8-15(32-33-22(18)35)10-34-11-31-21(24(27,28)29)20(23(34)36)37-16-6-13(9-30)5-14(25)7-16/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267230
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-1,6-dihydropyridazin-...)
Show SMILES FC(F)(F)c1ncn(Cc2ccc(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H9ClF3N5O3/c18-10-3-9(6-22)4-12(5-10)29-14-15(17(19,20)21)23-8-26(16(14)28)7-11-1-2-13(27)25-24-11/h1-5,8H,7H2,(H,25,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267258
PNG
(3-chloro-5-((1-((5- (2,4-difluorophenyl)- 6-oxo-1,...)
Show SMILES Fc1ccc(c(F)c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11ClF5N5O3/c24-12-3-11(8-30)4-15(5-12)37-19-20(23(27,28)29)31-10-34(22(19)36)9-14-7-17(21(35)33-32-14)16-2-1-13(25)6-18(16)26/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267357
PNG
(3-chloro-5-((1-((2-methyl-6-oxo-1,6-dihydropyrimid...)
Show SMILES Cc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C18H11ClF3N5O3/c1-9-24-6-11(16(28)26-9)7-27-8-25-15(18(20,21)22)14(17(27)29)30-13-3-10(5-23)2-12(19)4-13/h2-4,6,8H,7H2,1H3,(H,24,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267403
PNG
(3-chloro-5-((1-((6-(1,1- difluoroethyl)-3-oxo- 2,3...)
Show SMILES CC(F)(F)c1cc(Cn2cnc(C(F)F)c(Oc3cc(Cl)cc(c3)C#N)c2=O)c(=O)[nH]n1
Show InChI InChI=1S/C19H12ClF4N5O3/c1-19(23,24)13-4-10(17(30)28-27-13)7-29-8-26-14(16(21)22)15(18(29)31)32-12-3-9(6-25)2-11(20)5-12/h2-5,8,16H,7H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267277
PNG
(3-chloro-5-((1-((5-(3- cyanophenyl)-6-oxo- 1,6-dih...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3cccc(c3)C#N)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H12ClF3N6O3/c25-16-5-14(10-30)6-18(7-16)37-20-21(24(26,27)28)31-12-34(23(20)36)11-17-8-19(22(35)33-32-17)15-3-1-2-13(4-15)9-29/h1-8,12H,11H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267229
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-5-(trifluoromethyl)-1...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(c(=O)[nH]n2)C(F)(F)F)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C18H8ClF6N5O3/c19-9-1-8(5-26)2-11(3-9)33-13-14(18(23,24)25)27-7-30(16(13)32)6-10-4-12(17(20,21)22)15(31)29-28-10/h1-4,7H,6H2,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267318
PNG
(6-((5-(3-chloro-5-cyanophenoxy)-6-oxo-4-(trifluoro...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(C#N)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C18H8ClF3N6O3/c19-11-1-9(5-23)2-13(4-11)31-14-15(18(20,21)22)25-8-28(17(14)30)7-12-3-10(6-24)16(29)27-26-12/h1-4,8H,7H2,(H,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267349
PNG
(3-chloro-5-((1-((6- (4-(2,2-difluoro-1- hydroxyeth...)
Show SMILES OC(C(F)F)c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C25H15ClF5N5O4/c26-16-5-12(9-32)6-17(8-16)40-20-21(25(29,30)31)33-11-36(24(20)39)10-15-7-18(34-35-23(15)38)13-1-3-14(4-2-13)19(37)22(27)28/h1-8,11,19,22,37H,10H2,(H,35,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267359
PNG
(3-chloro-5-((1-((2-hydroxy-6-oxo-1,6-dihydropyrimi...)
Show SMILES Oc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C17H9ClF3N5O4/c18-10-1-8(4-22)2-11(3-10)30-12-13(17(19,20)21)24-7-26(15(12)28)6-9-5-23-16(29)25-14(9)27/h1-3,5,7H,6H2,(H2,23,25,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267304
PNG
(3-chloro-5-((6-oxo-1-((6- oxo-5-(pyridin-4-yl)-1,6...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccncc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C22H12ClF3N6O3/c23-14-5-12(9-27)6-16(7-14)35-18-19(22(24,25)26)29-11-32(21(18)34)10-15-8-17(20(33)31-30-15)13-1-3-28-4-2-13/h1-8,11H,10H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267271
PNG
(3-chloro-5-((1-((5- (2,5-difluorophenyl)- 6-oxo-1,...)
Show SMILES Fc1ccc(F)c(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11ClF5N5O3/c24-12-3-11(8-30)4-15(5-12)37-19-20(23(27,28)29)31-10-34(22(19)36)9-14-7-17(21(35)33-32-14)16-6-13(25)1-2-18(16)26/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267406
PNG
(3-((4-(1,1- difluoroethyl)-1-((6- (1,1-difluoroeth...)
Show SMILES CC(F)(F)c1cc(Cn2cnc(c(Oc3cccc(C#N)c3F)c2=O)C(C)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C20H14F5N5O3/c1-19(22,23)13-6-11(17(31)29-28-13)8-30-9-27-16(20(2,24)25)15(18(30)32)33-12-5-3-4-10(7-26)14(12)21/h3-6,9H,8H2,1-2H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267402
PNG
(3-((1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyr...)
Show SMILES CC(F)(F)c1cc(Cn2cnc(c(Oc3cccc([N+]#[C-])c3F)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C19H11F6N5O3/c1-18(21,22)12-6-9(16(31)29-28-12)7-30-8-27-15(19(23,24)25)14(17(30)32)33-11-5-3-4-10(26-2)13(11)20/h3-6,8H,7H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267248
PNG
(3-chloro-5-((1-((5-(2- fluorophenyl)-6-oxo- 1,6-di...)
Show SMILES Fc1ccccc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H12ClF4N5O3/c24-13-5-12(9-29)6-15(7-13)36-19-20(23(26,27)28)30-11-33(22(19)35)10-14-8-17(21(34)32-31-14)16-3-1-2-4-18(16)25/h1-8,11H,10H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267321
PNG
(3-chloro-5-((1-((5-(5-fluoropyridin-2-yl)-6-oxo-1,...)
Show SMILES Fc1ccc(nc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C22H11ClF4N6O3/c23-12-3-11(7-28)4-15(5-12)36-18-19(22(25,26)27)30-10-33(21(18)35)9-14-6-16(20(34)32-31-14)17-2-1-13(24)8-29-17/h1-6,8,10H,9H2,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267374
PNG
(3-chloro-5-((1-((2-(3- fluorophenyl)-6-oxo-1,6- di...)
Show SMILES Fc1cccc(c1)-c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C23H12ClF4N5O3/c24-15-4-12(8-29)5-17(7-15)36-18-19(23(26,27)28)31-11-33(22(18)35)10-14-9-30-20(32-21(14)34)13-2-1-3-16(25)6-13/h1-7,9,11H,10H2,(H,30,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267369
PNG
(3-chloro-5-((1-((2- cyclopropyl-6-oxo-1,6- dihydro...)
Show SMILES FC(F)(F)c1ncn(Cc2cnc([nH]c2=O)C2CC2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H13ClF3N5O3/c21-13-3-10(6-25)4-14(5-13)32-15-16(20(22,23)24)27-9-29(19(15)31)8-12-7-26-17(11-1-2-11)28-18(12)30/h3-5,7,9,11H,1-2,8H2,(H,26,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267368
PNG
(3-chloro-5-((1-((2-ethyl- 6-oxo-1,6- dihydropyrimi...)
Show SMILES CCc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C19H13ClF3N5O3/c1-2-14-25-7-11(17(29)27-14)8-28-9-26-16(19(21,22)23)15(18(28)30)31-13-4-10(6-24)3-12(20)5-13/h3-5,7,9H,2,8H2,1H3,(H,25,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267372
PNG
(3-chloro-5-((6-oxo-1-((6- oxo-2-(1H-pyrazol-5-yl)-...)
Show SMILES FC(F)(F)c1ncn(Cc2cnc([nH]c2=O)-c2ccn[nH]2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H11ClF3N7O3/c21-12-3-10(6-25)4-13(5-12)34-15-16(20(22,23)24)27-9-31(19(15)33)8-11-7-26-17(29-18(11)32)14-1-2-28-30-14/h1-5,7,9H,8H2,(H,28,30)(H,26,29,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267230
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-1,6-dihydropyridazin-...)
Show SMILES FC(F)(F)c1ncn(Cc2ccc(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H9ClF3N5O3/c18-10-3-9(6-22)4-12(5-10)29-14-15(17(19,20)21)23-8-26(16(14)28)7-11-1-2-13(27)25-24-11/h1-5,8H,7H2,(H,25,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267266
PNG
(3-chloro-5-((1-((5-(3- chloro-2- fluorophenyl)-6-o...)
Show SMILES Fc1c(Cl)cccc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-12-4-11(8-30)5-14(6-12)37-19-20(23(27,28)29)31-10-34(22(19)36)9-13-7-16(21(35)33-32-13)15-2-1-3-17(25)18(15)26/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267361
PNG
(3-chloro-5-((1-((2-(methylamino)-6-oxo-1,6-dihydro...)
Show SMILES CNc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C18H12ClF3N6O3/c1-24-17-25-6-10(15(29)27-17)7-28-8-26-14(18(20,21)22)13(16(28)30)31-12-3-9(5-23)2-11(19)4-12/h2-4,6,8H,7H2,1H3,(H2,24,25,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267292
PNG
(3-chloro-5-((1-((5-(4- (2,2-difluoro-1- hydroxyeth...)
Show SMILES OC(C(F)F)c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C25H15ClF5N5O4/c26-15-5-12(9-32)6-17(7-15)40-20-21(25(29,30)31)33-11-36(24(20)39)10-16-8-18(23(38)35-34-16)13-1-3-14(4-2-13)19(37)22(27)28/h1-8,11,19,22,37H,10H2,(H,35,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267335
PNG
(3-chloro-5-((1-((6- (1-methyl-1H- pyrazol-4-yl)-3-...)
Show SMILES Cn1cc(cn1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C21H13ClF3N7O3/c1-31-8-13(7-28-31)16-4-12(19(33)30-29-16)9-32-10-27-18(21(23,24)25)17(20(32)34)35-15-3-11(6-26)2-14(22)5-15/h2-5,7-8,10H,9H2,1H3,(H,30,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267262
PNG
(3-chloro-5-((1-((5-(2- fluoro-5- methylphenyl)-6-o...)
Show SMILES Cc1ccc(F)c(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O3/c1-12-2-3-19(26)17(4-12)18-8-15(32-33-22(18)35)10-34-11-31-21(24(27,28)29)20(23(34)36)37-16-6-13(9-30)5-14(25)7-16/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267286
PNG
(3-chloro-5-((1-((5-(2- fluoro-5- methoxyphenyl)-6-...)
Show SMILES COc1ccc(F)c(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O4/c1-37-15-2-3-19(26)17(8-15)18-7-14(32-33-22(18)35)10-34-11-31-21(24(27,28)29)20(23(34)36)38-16-5-12(9-30)4-13(25)6-16/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267285
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(2,3,4- trifluorop...)
Show SMILES Fc1ccc(c(F)c1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H10ClF6N5O3/c24-11-3-10(7-31)4-13(5-11)38-19-20(23(28,29)30)32-9-35(22(19)37)8-12-6-15(21(36)34-33-12)14-1-2-16(25)18(27)17(14)26/h1-6,9H,8H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267270
PNG
(3-chloro-5-((1-((5-(5- chloro-2- fluorophenyl)-6-o...)
Show SMILES Fc1ccc(Cl)cc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-12-1-2-18(26)16(6-12)17-7-14(32-33-21(17)35)9-34-10-31-20(23(27,28)29)19(22(34)36)37-15-4-11(8-30)3-13(25)5-15/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267278
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(3,4,5- trifluorop...)
Show SMILES Fc1cc(cc(F)c1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H10ClF6N5O3/c24-12-1-10(7-31)2-14(5-12)38-19-20(23(28,29)30)32-9-35(22(19)37)8-13-6-15(21(36)34-33-13)11-3-16(25)18(27)17(26)4-11/h1-6,9H,8H2,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267296
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(pyridin-3- yl)-1,...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3cccnc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C22H12ClF3N6O3/c23-14-4-12(8-27)5-16(6-14)35-18-19(22(24,25)26)29-11-32(21(18)34)10-15-7-17(20(33)31-30-15)13-2-1-3-28-9-13/h1-7,9,11H,10H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267362
PNG
(3-chloro-5-((1-((4- methoxy-2- (methylamino)pyrimi...)
Show SMILES CNc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(OC)n1
Show InChI InChI=1S/C19H14ClF3N6O3/c1-25-18-26-7-11(16(28-18)31-2)8-29-9-27-15(19(21,22)23)14(17(29)30)32-13-4-10(6-24)3-12(20)5-13/h3-5,7,9H,8H2,1-2H3,(H,25,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267284
PNG
(3-chloro-5-((1-((5-(3- fluoro-5- methoxyphenyl)-6-...)
Show SMILES COc1cc(F)cc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H14ClF4N5O4/c1-37-17-5-13(4-15(26)7-17)19-8-16(32-33-22(19)35)10-34-11-31-21(24(27,28)29)20(23(34)36)38-18-3-12(9-30)2-14(25)6-18/h2-8,11H,10H2,1H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267382
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-2-(1H-pyrrolo[2,3-b]p...)
Show SMILES FC(F)(F)c1ncn(Cc2cnc([nH]c2=O)-c2ccnc3[nH]ccc23)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H13ClF3N7O3/c25-14-5-12(8-29)6-15(7-14)38-18-19(24(26,27)28)33-11-35(23(18)37)10-13-9-32-21(34-22(13)36)17-2-4-31-20-16(17)1-3-30-20/h1-7,9,11H,10H2,(H,30,31)(H,32,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267280
PNG
(3-chloro-5-((1-((5- (2,3- dihydrobenzofuran-7- yl)...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3cccc4CCOc34)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C25H15ClF3N5O4/c26-15-6-13(10-30)7-17(8-15)38-21-22(25(27,28)29)31-12-34(24(21)36)11-16-9-19(23(35)33-32-16)18-3-1-2-14-4-5-37-20(14)18/h1-3,6-9,12H,4-5,11H2,(H,33,35)
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267316
PNG
(3-chloro-5-((6-oxo-1-((6-oxo-5-(1H-pyrazol-1-yl)-1...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-n3cccn3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H11ClF3N7O3/c21-12-4-11(8-25)5-14(6-12)34-16-17(20(22,23)24)26-10-30(19(16)33)9-13-7-15(18(32)29-28-13)31-3-1-2-27-31/h1-7,10H,9H2,(H,29,32)
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267239
PNG
(3-chloro-5-((1-((5-(fluoromethyl)-6-oxo-1,6-dihydr...)
Show SMILES FCc1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C18H10ClF4N5O3/c19-11-1-9(6-24)2-13(4-11)31-14-15(18(21,22)23)25-8-28(17(14)30)7-12-3-10(5-20)16(29)27-26-12/h1-4,8H,5,7H2,(H,27,29)
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n/an/a 12n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267356
PNG
(3-chloro-5-((1-((2-(methylthio)-6-oxo-1,6-dihydrop...)
Show SMILES CSc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C18H11ClF3N5O3S/c1-31-17-24-6-10(15(28)26-17)7-27-8-25-14(18(20,21)22)13(16(27)29)30-12-3-9(5-23)2-11(19)4-12/h2-4,6,8H,7H2,1H3,(H,24,26,28)
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n/an/a 12n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267290
PNG
(3-chloro-5-((1-((5-(4- (methylsulfonyl) phenyl)-6-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H15ClF3N5O5S/c1-39(36,37)18-4-2-14(3-5-18)19-9-16(31-32-22(19)34)11-33-12-30-21(24(26,27)28)20(23(33)35)38-17-7-13(10-29)6-15(25)8-17/h2-9,12H,11H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267354
PNG
(3-((1-((2-(tert-butyl)-6-oxo-1,6-dihydropyrimidin-...)
Show SMILES CC(C)(C)c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C21H17ClF3N5O3/c1-20(2,3)19-27-8-12(17(31)29-19)9-30-10-28-16(21(23,24)25)15(18(30)32)33-14-5-11(7-26)4-13(22)6-14/h4-6,8,10H,9H2,1-3H3,(H,27,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267405
PNG
(3-chloro-5-((1-((6-(1,1- difluoroethyl)-3-oxo- 2,3...)
Show SMILES Cc1ncn(Cc2cc(n[nH]c2=O)C(C)(F)F)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C19H14ClF2N5O3/c1-10-16(30-14-4-11(7-23)3-13(20)6-14)18(29)27(9-24-10)8-12-5-15(19(2,21)22)25-26-17(12)28/h3-6,9H,8H2,1-2H3,(H,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267330
PNG
(3-chloro-5-((1-((5-methoxy-6-oxo-1,6-dihydropyrida...)
Show SMILES COc1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)[N+]#[C-])c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C18H11ClF3N5O4/c1-23-10-3-9(19)4-12(5-10)31-14-15(18(20,21)22)24-8-27(17(14)29)7-11-6-13(30-2)16(28)26-25-11/h3-6,8H,7H2,2H3,(H,26,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267343
PNG
(3-chloro-5-((6-oxo- 1-((3-oxo-6-(4- (trifluorometh...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C24H12ClF6N5O3/c25-16-5-12(9-32)6-17(8-16)39-19-20(24(29,30)31)33-11-36(22(19)38)10-14-7-18(34-35-21(14)37)13-1-3-15(4-2-13)23(26,27)28/h1-8,11H,10H2,(H,35,37)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267238
PNG
(3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihyd...)
Show SMILES CC(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C19H12ClF4N5O3/c1-9(21)14-5-12(27-28-17(14)30)7-29-8-26-16(19(22,23)24)15(18(29)31)32-13-3-10(6-25)2-11(20)4-13/h2-5,8-9H,7H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267255
PNG
(3-chloro-5-((1-((5-(3- fluoro-4- isopropoxyphenyl)...)
Show SMILES CC(C)Oc1ccc(cc1F)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C26H18ClF4N5O4/c1-13(2)39-21-4-3-15(7-20(21)28)19-9-17(34-35-24(19)37)11-36-12-33-23(26(29,30)31)22(25(36)38)40-18-6-14(10-32)5-16(27)8-18/h3-9,12-13H,11H2,1-2H3,(H,35,37)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267365
PNG
(3-Chloro-5-[1-(2- dimethylamino-6-oxo- 1,6-dihydro...)
Show SMILES CN(C)c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C19H14ClF3N6O3/c1-28(2)18-25-7-11(16(30)27-18)8-29-9-26-15(19(21,22)23)14(17(29)31)32-13-4-10(6-24)3-12(20)5-13/h3-5,7,9H,8H2,1-2H3,(H,25,27,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267250
PNG
(3-chloro-5-((1-((5-(3- chloro-5- fluorophenyl)-6-o...)
Show SMILES Fc1cc(Cl)cc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-13-1-11(8-30)2-17(6-13)37-19-20(23(27,28)29)31-10-34(22(19)36)9-16-7-18(21(35)33-32-16)12-3-14(25)5-15(26)4-12/h1-7,10H,9H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267373
PNG
(3-chloro-5-((6-oxo-1-((6- oxo-2-phenyl-1,6- dihydr...)
Show SMILES FC(F)(F)c1ncn(Cc2cnc([nH]c2=O)-c2ccccc2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H13ClF3N5O3/c24-16-6-13(9-28)7-17(8-16)35-18-19(23(25,26)27)30-12-32(22(18)34)11-15-10-29-20(31-21(15)33)14-4-2-1-3-5-14/h1-8,10,12H,11H2,(H,29,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267308
PNG
(3-chloro-5-((1-((5-(5- methoxypyridin-3-yl)-6- oxo...)
Show SMILES COc1cncc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H14ClF3N6O4/c1-36-17-4-13(8-29-9-17)18-6-15(31-32-21(18)34)10-33-11-30-20(23(25,26)27)19(22(33)35)37-16-3-12(7-28)2-14(24)5-16/h2-6,8-9,11H,10H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267306
PNG
(3-chloro-5-((1-((5-(6- methylpyridin-3-yl)-6- oxo-...)
Show SMILES Cc1ccc(cn1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H14ClF3N6O3/c1-12-2-3-14(9-29-12)18-7-16(31-32-21(18)34)10-33-11-30-20(23(25,26)27)19(22(33)35)36-17-5-13(8-28)4-15(24)6-17/h2-7,9,11H,10H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267303
PNG
(3-chloro-5-((1-((5-(5- methylpyridin-3-yl)-6- oxo-...)
Show SMILES Cc1cncc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H14ClF3N6O3/c1-12-2-14(9-29-8-12)18-6-16(31-32-21(18)34)10-33-11-30-20(23(25,26)27)19(22(33)35)36-17-4-13(7-28)3-15(24)5-17/h2-6,8-9,11H,10H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267293
PNG
(3-chloro-5-((1-((5-(3- (methylsulfonyl) phenyl)-6-...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H15ClF3N5O5S/c1-39(36,37)18-4-2-3-14(7-18)19-9-16(31-32-22(19)34)11-33-12-30-21(24(26,27)28)20(23(33)35)38-17-6-13(10-29)5-15(25)8-17/h2-9,12H,11H2,1H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267328
PNG
(3-chloro-5-((1-((5-(1,1-difluoroethyl)-6-oxo-1,6-d...)
Show SMILES CC(F)(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C19H11ClF5N5O3/c1-18(21,22)13-5-11(28-29-16(13)31)7-30-8-27-15(19(23,24)25)14(17(30)32)33-12-3-9(6-26)2-10(20)4-12/h2-5,8H,7H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267272
PNG
(3-chloro-5-((1-((5-(4- isopropylphenyl)-6- oxo-1,6...)
Show SMILES CC(C)c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C26H19ClF3N5O3/c1-14(2)16-3-5-17(6-4-16)21-10-19(33-34-24(21)36)12-35-13-32-23(26(28,29)30)22(25(35)37)38-20-8-15(11-31)7-18(27)9-20/h3-10,13-14H,12H2,1-2H3,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267297
PNG
(3-chloro-5-((1-((5-(6- methoxypyridin-3- yl)-6-oxo...)
Show SMILES COc1ccc(cn1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H14ClF3N6O4/c1-36-18-3-2-13(9-29-18)17-7-15(31-32-21(17)34)10-33-11-30-20(23(25,26)27)19(22(33)35)37-16-5-12(8-28)4-14(24)6-16/h2-7,9,11H,10H2,1H3,(H,32,34)
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n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267371
PNG
(3-chloro-5-((1-((2-(2- fluorophenyl)-6-oxo-1,6- di...)
Show SMILES Fc1ccccc1-c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C23H12ClF4N5O3/c24-14-5-12(8-29)6-15(7-14)36-18-19(23(26,27)28)31-11-33(22(18)35)10-13-9-30-20(32-21(13)34)16-3-1-2-4-17(16)25/h1-7,9,11H,10H2,(H,30,32,34)
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n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267311
PNG
(3-chloro-5-((6-oxo-1-((6- oxo-5-(quinolin-3-yl)- 1...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3cnc4ccccc4c3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C26H14ClF3N6O3/c27-17-5-14(10-31)6-19(8-17)39-22-23(26(28,29)30)33-13-36(25(22)38)12-18-9-20(24(37)35-34-18)16-7-15-3-1-2-4-21(15)32-11-16/h1-9,11,13H,12H2,(H,35,37)
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n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267383
PNG
(3-chloro-5-((1-((2-(4-(difluoromethoxy)phenyl)-6-o...)
Show SMILES FC(F)Oc1ccc(cc1)-c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C24H13ClF5N5O4/c25-15-5-12(8-31)6-17(7-15)38-18-19(24(28,29)30)33-11-35(22(18)37)10-14-9-32-20(34-21(14)36)13-1-3-16(4-2-13)39-23(26)27/h1-7,9,11,23H,10H2,(H,32,34,36)
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n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267401
PNG
(3-((4-(1,1- difluoroethyl)-1-((6- (difluoromethyl)...)
Show SMILES CC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)C(F)F)c(=O)c1Oc1cccc(C#N)c1F
Show InChI InChI=1S/C19H12F5N5O3/c1-19(23,24)15-14(32-12-4-2-3-9(6-25)13(12)20)18(31)29(8-26-15)7-10-5-11(16(21)22)27-28-17(10)30/h2-5,8,16H,7H2,1H3,(H,28,30)
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n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267358
PNG
(3-chloro-5-((4-cyclopropyl-6-oxo-1-((6-oxo-1,6-dih...)
Show SMILES Clc1cc(Oc2c(ncn(Cc3ccc(=O)[nH]n3)c2=O)C2CC2)cc(c1)C#N
Show InChI InChI=1S/C19H14ClN5O3/c20-13-5-11(8-21)6-15(7-13)28-18-17(12-1-2-12)22-10-25(19(18)27)9-14-3-4-16(26)24-23-14/h3-7,10,12H,1-2,9H2,(H,24,26)
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n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267312
PNG
(3-((1-((5-(4-(1-amino- 2,2,2- trifluoroethyl)pheny...)
Show SMILES NC(c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C25H15ClF6N6O3/c26-15-5-12(9-33)6-17(7-15)41-19-21(25(30,31)32)35-11-38(23(19)40)10-16-8-18(22(39)37-36-16)13-1-3-14(4-2-13)20(34)24(27,28)29/h1-8,11,20H,10,34H2,(H,37,39)
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267310
PNG
(3-chloro-5-((1-((5-(2- fluoropyridin-3-yl)-6- oxo-...)
Show SMILES Fc1ncccc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C22H11ClF4N6O3/c23-12-4-11(8-28)5-14(6-12)36-17-18(22(25,26)27)30-10-33(21(17)35)9-13-7-16(20(34)32-31-13)15-2-1-3-29-19(15)24/h1-7,10H,9H2,(H,32,34)
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267370
PNG
(3-chloro-5-((1-((2-(4-fluorophenyl)-6-oxo-1,6-dihy...)
Show SMILES Fc1ccc(cc1)-c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C23H12ClF4N5O3/c24-15-5-12(8-29)6-17(7-15)36-18-19(23(26,27)28)31-11-33(22(18)35)10-14-9-30-20(32-21(14)34)13-1-3-16(25)4-2-13/h1-7,9,11H,10H2,(H,30,32,34)
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n/an/a 19n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267329
PNG
(3-((1-((5-acetyl-6-oxo-1,6-dihydropyridazin-3-yl)m...)
Show SMILES CC(=O)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C19H11ClF3N5O4/c1-9(29)14-5-12(26-27-17(14)30)7-28-8-25-16(19(21,22)23)15(18(28)31)32-13-3-10(6-24)2-11(20)4-13/h2-5,8H,7H2,1H3,(H,27,30)
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n/an/a 19n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267298
PNG
(3-chloro-5-((1-((5-(4- cyanophenyl)-6-oxo- 1,6-dih...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccc(cc3)C#N)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H12ClF3N6O3/c25-16-5-14(10-30)6-18(7-16)37-20-21(24(26,27)28)31-12-34(23(20)36)11-17-8-19(22(35)33-32-17)15-3-1-13(9-29)2-4-15/h1-8,12H,11H2,(H,33,35)
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267326
PNG
(3-chloro-5-((1-((5-(difluoromethyl)-6-oxo-1,6-dihy...)
Show SMILES FC(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C18H9ClF5N5O3/c19-9-1-8(5-25)2-11(3-9)32-13-14(18(22,23)24)26-7-29(17(13)31)6-10-4-12(15(20)21)16(30)28-27-10/h1-4,7,15H,6H2,(H,28,30)
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267340
PNG
(3-chloro-5-((6-oxo- 1-((3-oxo-6-(4- (trifluorometh...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C24H12ClF6N5O4/c25-15-5-12(9-32)6-17(8-15)39-19-20(23(26,27)28)33-11-36(22(19)38)10-14-7-18(34-35-21(14)37)13-1-3-16(4-2-13)40-24(29,30)31/h1-8,11H,10H2,(H,35,37)
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n/an/a 21n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267387
PNG
(3-(difluoromethoxy)-5-(6-oxo-1-((6-oxo-1,6-dihydro...)
Show SMILES FC(F)Oc1cc(Oc2c(ncn(Cc3ccc(=O)[nH]n3)c2=O)C(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C18H10F5N5O4/c19-17(20)32-12-4-9(6-24)3-11(5-12)31-14-15(18(21,22)23)25-8-28(16(14)30)7-10-1-2-13(29)27-26-10/h1-5,8,17H,7H2,(H,27,29)
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267323
PNG
(US9718819, 100 | methyl 6-((5-(3-chloro-5-cyanophe...)
Show SMILES COC(=O)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C19H11ClF3N5O5/c1-32-18(31)13-5-11(26-27-16(13)29)7-28-8-25-15(19(21,22)23)14(17(28)30)33-12-3-9(6-24)2-10(20)4-12/h2-5,8H,7H2,1H3,(H,27,29)
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n/an/a 23n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267243
PNG
(3-((6-oxo-1-((6-oxo-1,6- dihydropyridazin-3- yl)me...)
Show SMILES FC(F)(F)c1cc(Oc2c(ncn(Cc3ccc(=O)[nH]n3)c2=O)C(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C18H9F6N5O3/c19-17(20,21)10-3-9(6-25)4-12(5-10)32-14-15(18(22,23)24)26-8-29(16(14)31)7-11-1-2-13(30)28-27-11/h1-5,8H,7H2,(H,28,30)
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n/an/a 24n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267380
PNG
(3-((1-((2-acetyl-6-oxo-1,6-dihydropyrimidin-5-yl)m...)
Show SMILES CC(=O)c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C19H11ClF3N5O4/c1-9(29)16-25-6-11(17(30)27-16)7-28-8-26-15(19(21,22)23)14(18(28)31)32-13-3-10(5-24)2-12(20)4-13/h2-4,6,8H,7H2,1H3,(H,25,27,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267385
PNG
(2-fluoro-3-(6-oxo-1-((6-oxo-1,6-dihydropyridazin-3...)
Show SMILES Fc1c(Oc2c(ncn(Cc3ccc(=O)[nH]n3)c2=O)C(F)(F)F)cccc1C#N
Show InChI InChI=1S/C17H9F4N5O3/c18-13-9(6-22)2-1-3-11(13)29-14-15(17(19,20)21)23-8-26(16(14)28)7-10-4-5-12(27)25-24-10/h1-5,8H,7H2,(H,25,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267247
PNG
(3-chloro-5-((6-oxo-1- ((6-oxo-5-(4- (trifluorometh...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C24H12ClF6N5O4/c25-14-5-12(9-32)6-17(7-14)39-19-20(23(26,27)28)33-11-36(22(19)38)10-15-8-18(21(37)35-34-15)13-1-3-16(4-2-13)40-24(29,30)31/h1-8,11H,10H2,(H,35,37)
PDB