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Patent code US9718825

Compile Data Set for Download or QSAR

Found 648 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269150
PNG
(US9718825, Example 596)
Show SMILES CCOc1nc(cc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1
PDB
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n/an/a<0.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269143
PNG
(US9718825, Example 589)
Show SMILES CC(C)N1CC(COc2nc(cc3[nH]nc(C)c23)-c2ccc(NS(=O)(=O)c3cc(C)ccc3F)cc2)C1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268829
PNG
(US9718825, Example 234)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269083
PNG
(US9718825, Example 527)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncc2c(N)n[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269008
PNG
(US9718825, Example 451)
Show SMILES CCOc1nc(nc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268860
PNG
(US9718825, Example 265)
Show SMILES CN1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268850
PNG
(US9718825, Example 255 | US9718825, Example 261)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268828
PNG
(US9718825, Example 233)
Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269092
PNG
(US9718825, Example 537)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncc2c(NC(=O)C3CC3)n[nH]c2n1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268847
PNG
(US9718825, Example 252)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268698
PNG
(US9718825, Example 100)
Show SMILES Cc1n[nH]c2nc(nc(NC3CCCC(O)C3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2C#N)cc1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268875
PNG
(US9718825, Example 300)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269021
PNG
(US9718825, Example 464)
Show SMILES Cc1nc(nc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268626
PNG
(US9718825, Example 23)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2ccncc2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268638
PNG
(US9718825, Example 40)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(-n2cncn2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268648
PNG
(US9718825, Example 50)
Show SMILES NCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268660
PNG
(US9718825, Example 62)
Show SMILES NCCCOc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268619
PNG
(US9718825, Example 15)
Show SMILES Clc1cccc(c1Cl)S(=O)(=O)Nc1ccc(cc1)-c1nc(N2CCNCC2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268644
PNG
(US9718825, Example 46)
Show SMILES NCCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268649
PNG
(US9718825, Example 51)
Show SMILES NCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268635
PNG
(US9718825, Example 36)
Show SMILES OCCCCOc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268627
PNG
(US9718825, Example 24)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2ccncc2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268650
PNG
(US9718825, Example 52)
Show SMILES NCCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268629
PNG
(US9718825, Example 26)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2cccnc2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM50043015
PNG
(CHEMBL3355025 | US9718825, Example 1)
Show SMILES Cc1n[nH]c2nc(ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C18H13Cl2N5O2S/c1-10-14-9-21-17(22-18(14)24-23-10)11-2-5-13(6-3-11)25-28(26,27)16-8-12(19)4-7-15(16)20/h2-9,25H,1H3,(H,21,22,23,24)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268621
PNG
(US9718825, Example 17)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(N2CCNCC2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268620
PNG
(US9718825, Example 16)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(N2CCNCC2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268859
PNG
(US9718825, Example 264)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2CCCNC2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268630
PNG
(US9718825, Example 27)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2cccnc2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM50043016
PNG
(CHEMBL3355026 | US9718825, Example 3)
Show SMILES OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C23H21ClFN5O4S/c24-14-3-10-19(25)20(11-14)35(32,33)30-15-4-1-13(2-5-15)21-27-22-18(12-26-29-22)23(28-21)34-17-8-6-16(31)7-9-17/h1-5,10-12,16-17,30-31H,6-9H2,(H,26,27,28,29)
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Patents


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n/an/a<1.20n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268740
PNG
(US9718825, Example 142)
Show SMILES Cc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(C2CC2)c2cn[nH]c2n1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268610
PNG
(2,5-Dichloro-N-[4-(4-pyridin-3-yl-1H-pyrazolo[3,4-...)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-c2cccnc2)c2cn[nH]c2n1
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268659
PNG
(US9718825, Example 61)
Show SMILES OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM50043018
PNG
(CHEMBL3355028 | US9718825, Example 63)
Show SMILES NCCCOc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C20H18Cl2N6O3S/c21-13-4-7-16(22)17(10-13)32(29,30)28-14-5-2-12(3-6-14)18-25-19-15(11-24-27-19)20(26-18)31-9-1-8-23/h2-7,10-11,28H,1,8-9,23H2,(H,24,25,26,27)
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n/an/a<1.20n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268628
PNG
(US9718825, Example 25)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-c2ccncc2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268614
PNG
(US9718825, Example 10)
Show SMILES Cc1n[nH]c2nc(ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268639
PNG
(US9718825, Example 41)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-n2cncn2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268637
PNG
(US9718825, Example 39)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-n2ccnc2)c2cn[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268854
PNG
(US9718825, Example 259)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268851
PNG
(US9718825, Example 256)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2CCNCC2(F)F)c2c(C)n[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269140
PNG
(US9718825, Example 586)
Show SMILES Cc1n[nH]c2cc(nc(OC3CCN(CC3)C3CC3)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268914
PNG
(US9718825, Example 339)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCCNC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268640
PNG
(US9718825, Example 42)
Show SMILES OCCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269089
PNG
(2-Chloro-N-[2-fluoro-4-(3-methyl-1H-pyrazolo[3,4-d...)
Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1F)-c1ncc2c(C)n[nH]c2n1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268697
PNG
(US9718825, Example 99)
Show SMILES Cc1n[nH]c2nc(nc(NC3CCCC(O)C3)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
PDB
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269044
PNG
(US9718825, Example 487)
Show SMILES Nc1n[nH]c2nc(nc(C3CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
PDB
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n/an/a<1.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM269046
PNG
(US9718825, Example 489)
Show SMILES Nc1n[nH]c2nc(nc(C3CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
PDB
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n/an/a<1.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268714
PNG
(US9718825, Example 116)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCCC(N)=O)c2cn[nH]c2n1
PDB
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n/an/a<1.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268717
PNG
(US9718825, Example 119)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2C[C@@H](O)C[C@@H](O)C2)c2cn[nH]c2n1
PDB
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n/an/a<1.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM268750
PNG
(US9718825, Example 152)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC)c2c(N)n[nH]c2n1
PDB
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n/an/a<1.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)

More data for this
Ligand-Target Pair
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