Affinity Data by Patent

Patent code US9725430

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50209206 ((2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodopheny...) Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50158465 ((4-hydroxy-3,5-diiodophenyl)(2-methylbenzofuran-3-...) Show SMILES Cc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50158460 ((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...) Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (ED) (Homo sapiens (Human))	BDBM18964 (4-[(2-butyl-1-benzofuran-3-yl)carbonyl]phenol \| L ...) Show SMILES CCCCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (ED) (Homo sapiens (Human))	BDBM50158460 ((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...) Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM330348 (US9725430, Compound 1e) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM18964 (4-[(2-butyl-1-benzofuran-3-yl)carbonyl]phenol \| L ...) Show SMILES CCCCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM330350 (US9725430, Compound 1f) Show SMILES Cc1oc2ccccc2c1C(=O)c1ccc(O)c(I)c1 Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (ED) (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342279 ((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...) Show SMILES Show InChI	GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342287 ((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-hydroxyben...) Show SMILES Show InChI	GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM330353 (US9725430, Compound 1i) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (PTP1B) (Homo sapiens (human))	BDBM50158460 ((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...) Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (PTP1B) (Homo sapiens (human))	BDBM18964 (4-[(2-butyl-1-benzofuran-3-yl)carbonyl]phenol \| L ...) Show SMILES CCCCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	7.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342276 ((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...) Show SMILES CCc1oc2ccc(O)cc2c1C(=O)c1ccc(O)cc1 Show InChI	GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50158457 ((4-hydroxyphenyl)(2-methylbenzofuran-3-yl)methanon...) Show SMILES Cc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	8.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (PTP1B) (Homo sapiens (human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017)
CHILDREN HOSPITAL MEDICAL CENTER US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%