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Patent code US9725433

Compile Data Set for Download or QSAR
Found 164 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110647
PNG
(US8614234, 115 | US9725433, 115)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H20N4O4/c1-15-3-2-4-18(11-15)28-24(31)27-17-5-7-19(8-6-17)32-20-9-10-25-22(13-20)21-12-16(14-26-21)23(29)30/h2-14,26H,1H3,(H,29,30)(H2,27,28,31)
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n/an/a 2n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110608
PNG
(US8614234, 76 | US9725433, 76)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C25H21FN4O4/c1-15-4-3-5-17(10-15)29-25(32)30-21-7-6-18(12-20(21)26)34-19-8-9-27-23(13-19)22-11-16(14-28-22)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32)
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n/an/a 3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110598
PNG
(US8614234, 66 | US9725433, 66)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39)
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n/an/a 3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110597
PNG
(US8614234, 65 | US9725433, 65)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(C3)C(O)=O)cc2F)c1
Show InChI InChI=1S/C29H25F2N5O5/c1-16-2-4-21(30)24(10-16)35-29(40)34-23-5-3-19(12-22(23)31)41-20-6-8-32-26(13-20)25-11-18(14-33-25)27(37)36-9-7-17(15-36)28(38)39/h2-6,8,10-14,17,33H,7,9,15H2,1H3,(H,38,39)(H2,34,35,40)
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n/an/a 4n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110666
PNG
(US8614234, 134 | US9725433, 134)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H19FN4O4/c1-14-2-7-19(25)20(10-14)29-24(32)28-16-3-5-17(6-4-16)33-18-8-9-26-22(12-18)21-11-15(13-27-21)23(30)31/h2-13,27H,1H3,(H,30,31)(H2,28,29,32)
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n/an/a 4n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110610
PNG
(US8614234, 78 | US9725433, 78)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2)c1
Show InChI InChI=1S/C28H26FN5O5/c1-17-4-9-22(29)23(13-17)34-28(38)33-19-5-7-20(8-6-19)39-21-10-12-30-25(15-21)24-14-18(16-32-24)27(37)31-11-2-3-26(35)36/h4-10,12-16,32H,2-3,11H2,1H3,(H,31,37)(H,35,36)(H2,33,34,38)
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n/an/a 4n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110625
PNG
(US8614234, 93 | US9725433, 93)
Show SMILES CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)cc2)ccn1
Show InChI InChI=1S/C26H25N5O3/c1-3-27-25(32)18-14-23(29-16-18)24-15-22(11-12-28-24)34-21-9-7-19(8-10-21)30-26(33)31-20-6-4-5-17(2)13-20/h4-16,29H,3H2,1-2H3,(H,27,32)(H2,30,31,33)
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n/an/a 5n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110601
PNG
(US8614234, 69 | US9725433, 69)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C27H23F2N5O5/c1-15-2-4-19(28)22(10-15)34-27(38)33-21-5-3-17(12-20(21)29)39-18-6-8-30-24(13-18)23-11-16(14-32-23)26(37)31-9-7-25(35)36/h2-6,8,10-14,32H,7,9H2,1H3,(H,31,37)(H,35,36)(H2,33,34,38)
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n/an/a 5n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110615
PNG
(US8614234, 83 | US9725433, 83)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(C3)C(O)=O)cc2)c1
Show InChI InChI=1S/C29H26FN5O5/c1-17-2-7-23(30)24(12-17)34-29(39)33-20-3-5-21(6-4-20)40-22-8-10-31-26(14-22)25-13-19(15-32-25)27(36)35-11-9-18(16-35)28(37)38/h2-8,10,12-15,18,32H,9,11,16H2,1H3,(H,37,38)(H2,33,34,39)
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n/an/a 5n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110625
PNG
(US8614234, 93 | US9725433, 93)
Show SMILES CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)cc2)ccn1
Show InChI InChI=1S/C26H25N5O3/c1-3-27-25(32)18-14-23(29-16-18)24-15-22(11-12-28-24)34-21-9-7-19(8-10-21)30-26(33)31-20-6-4-5-17(2)13-20/h4-16,29H,3H2,1-2H3,(H,27,32)(H2,30,31,33)
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n/an/a 5n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110626
PNG
(US8614234, 94 | US9725433, 94)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(N)=O)cc2)c1
Show InChI InChI=1S/C24H21N5O3/c1-15-3-2-4-18(11-15)29-24(31)28-17-5-7-19(8-6-17)32-20-9-10-26-22(13-20)21-12-16(14-27-21)23(25)30/h2-14,27H,1H3,(H2,25,30)(H2,28,29,31)
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n/an/a 6n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110622
PNG
(US8614234, 90 | US9725433, 90)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC[C@@H](O)C3)cc2)c1
Show InChI InChI=1S/C29H29N5O4/c1-19-4-2-5-22(14-19)33-29(37)32-21-7-9-24(10-8-21)38-25-11-12-30-27(16-25)26-15-20(17-31-26)28(36)34-13-3-6-23(35)18-34/h2,4-5,7-12,14-17,23,31,35H,3,6,13,18H2,1H3,(H2,32,33,37)/t23-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330445
PNG
(N-[dimethyl(oxido)- lambda~4~-sulfanylidene]- 5-{4...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N=S(C)(C)=O)cc2)c1
Show InChI InChI=1S/C26H24FN5O4S/c1-16-4-9-21(27)22(12-16)31-26(34)30-18-5-7-19(8-6-18)36-20-10-11-28-24(14-20)23-13-17(15-29-23)25(33)32-37(2,3)35/h4-15,29H,1-3H3,(H2,30,31,34)
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n/an/a 8n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110624
PNG
(US8614234, 92 | US9725433, 92)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(O)CO)cc2)c1
Show InChI InChI=1S/C27H27N5O5/c1-17-3-2-4-20(11-17)32-27(36)31-19-5-7-22(8-6-19)37-23-9-10-28-25(13-23)24-12-18(14-29-24)26(35)30-15-21(34)16-33/h2-14,21,29,33-34H,15-16H2,1H3,(H,30,35)(H2,31,32,36)
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n/an/a 9n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110609
PNG
(US8614234, 77 | US9725433, 77)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCOCCOCCOCCO)cc2)c1
Show InChI InChI=1S/C32H36FN5O7/c1-22-2-7-27(33)28(18-22)38-32(41)37-24-3-5-25(6-4-24)45-26-8-9-34-30(20-26)29-19-23(21-36-29)31(40)35-10-12-42-14-16-44-17-15-43-13-11-39/h2-9,18-21,36,39H,10-17H2,1H3,(H,35,40)(H2,37,38,41)
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n/an/a 10n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110570
PNG
(US8614234, 38 | US9725433, 38)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCN3CCOCC3)cc2)c1
Show InChI InChI=1S/C31H33FN6O4/c1-21-3-8-26(32)27(17-21)37-31(40)36-23-4-6-24(7-5-23)42-25-9-11-33-29(19-25)28-18-22(20-35-28)30(39)34-10-2-12-38-13-15-41-16-14-38/h3-9,11,17-20,35H,2,10,12-16H2,1H3,(H,34,39)(H2,36,37,40)
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n/an/a 10n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110642
PNG
(US8614234, 110 | US9725433, 110)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCO)cc2)c1
Show InChI InChI=1S/C27H26FN5O4/c1-17-3-8-22(28)23(13-17)33-27(36)32-19-4-6-20(7-5-19)37-21-9-11-29-25(15-21)24-14-18(16-31-24)26(35)30-10-2-12-34/h3-9,11,13-16,31,34H,2,10,12H2,1H3,(H,30,35)(H2,32,33,36)
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n/an/a 10n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110573
PNG
(US8614234, 41 | US9725433, 41)
Show SMILES COC(=O)CNC(=O)c1cc(cs1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C27H23FN4O5S/c1-16-3-8-21(28)23(11-16)32-27(35)31-18-4-6-19(7-5-18)37-20-9-10-29-22(13-20)17-12-24(38-15-17)26(34)30-14-25(33)36-2/h3-13,15H,14H2,1-2H3,(H,30,34)(H2,31,32,35)
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n/an/a 11n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110572
PNG
(US8614234, 40 | US9725433, 40)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3csc(c3)C(=O)NCC(O)=O)cc2)c1
Show InChI InChI=1S/C26H21FN4O5S/c1-15-2-7-20(27)22(10-15)31-26(35)30-17-3-5-18(6-4-17)36-19-8-9-28-21(12-19)16-11-23(37-14-16)25(34)29-13-24(32)33/h2-12,14H,13H2,1H3,(H,29,34)(H,32,33)(H2,30,31,35)
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n/an/a 11n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110605
PNG
(US8614234, 73 | US9725433, 73)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CC[C@@H](O)C3)cc2F)c1
Show InChI InChI=1S/C28H26FN5O4/c1-17-3-2-4-19(11-17)32-28(37)33-24-6-5-21(13-23(24)29)38-22-7-9-30-26(14-22)25-12-18(15-31-25)27(36)34-10-8-20(35)16-34/h2-7,9,11-15,20,31,35H,8,10,16H2,1H3,(H2,32,33,37)/t20-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110675
PNG
(US8614234, 143 | US9725433, 143)
Show SMILES COC(=O)c1cc(c[nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C25H21FN4O4/c1-15-3-8-20(26)22(11-15)30-25(32)29-17-4-6-18(7-5-17)34-19-9-10-27-21(13-19)16-12-23(28-14-16)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32)
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n/an/a 12n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110580
PNG
(US8614234, 48 | US9725433, 48)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C27H24FN5O5/c1-16-3-2-4-18(11-16)32-27(37)33-22-6-5-19(13-21(22)28)38-20-7-9-29-24(14-20)23-12-17(15-31-23)26(36)30-10-8-25(34)35/h2-7,9,11-15,31H,8,10H2,1H3,(H,30,36)(H,34,35)(H2,32,33,37)
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n/an/a 12n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110606
PNG
(US8614234, 74 | US9725433, 74)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCCC(O)C3)cc2F)c1
Show InChI InChI=1S/C29H28FN5O4/c1-18-4-2-5-20(12-18)33-29(38)34-25-8-7-22(14-24(25)30)39-23-9-10-31-27(15-23)26-13-19(16-32-26)28(37)35-11-3-6-21(36)17-35/h2,4-5,7-10,12-16,21,32,36H,3,6,11,17H2,1H3,(H2,33,34,38)
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n/an/a 12n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110616
PNG
(US8614234, 84 | US9725433, 84)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(O)=O)cc2)c1
Show InChI InChI=1S/C26H22FN5O5/c1-15-2-7-20(27)21(10-15)32-26(36)31-17-3-5-18(6-4-17)37-19-8-9-28-23(12-19)22-11-16(13-29-22)25(35)30-14-24(33)34/h2-13,29H,14H2,1H3,(H,30,35)(H,33,34)(H2,31,32,36)
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n/an/a 13n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110554
PNG
(US8614234, 22 | US9725433, 22)
Show SMILES Cc1cccc(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)c2)c1
Show InChI InChI=1S/C24H19N3O4/c1-15-4-2-6-18(10-15)27-23(28)16-5-3-7-19(11-16)31-20-8-9-25-22(13-20)21-12-17(14-26-21)24(29)30/h2-14,26H,1H3,(H,27,28)(H,29,30)
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n/an/a 13n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110640
PNG
(US8614234, 108 | US9725433, 108)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)cc2)c1
Show InChI InChI=1S/C24H20FN5O4/c1-14-2-7-19(25)20(10-14)29-24(32)28-16-3-5-17(6-4-16)34-18-8-9-26-22(12-18)21-11-15(13-27-21)23(31)30-33/h2-13,27,33H,1H3,(H,30,31)(H2,28,29,32)
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n/an/a 13n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330444
PNG
(US9725433, 100 | methyl 4-{N-[(5-{4-[4-({[(2- fluo...)
Show SMILES COC(=O)CCCS(C)(=O)=NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
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n/an/a 13n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110608
PNG
(US8614234, 76 | US9725433, 76)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C25H21FN4O4/c1-15-4-3-5-17(10-15)29-25(32)30-21-7-6-18(12-20(21)26)34-19-8-9-27-23(13-19)22-11-16(14-28-22)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32)
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n/an/a 14n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110653
PNG
(US8614234, 121 | US9725433, 121)
Show SMILES OC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C24H16ClF3N4O4/c25-19-6-3-15(10-18(19)24(26,27)28)32-23(35)31-14-1-4-16(5-2-14)36-17-7-8-29-21(11-17)20-9-13(12-30-20)22(33)34/h1-12,30H,(H,33,34)(H2,31,32,35)
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n/an/a 14n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110623
PNG
(US8614234, 91 | US9725433, 91)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CC[C@@H](O)C3)cc2)c1
Show InChI InChI=1S/C28H27N5O4/c1-18-3-2-4-21(13-18)32-28(36)31-20-5-7-23(8-6-20)37-24-9-11-29-26(15-24)25-14-19(16-30-25)27(35)33-12-10-22(34)17-33/h2-9,11,13-16,22,30,34H,10,12,17H2,1H3,(H2,31,32,36)/t22-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110640
PNG
(US8614234, 108 | US9725433, 108)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)cc2)c1
Show InChI InChI=1S/C24H20FN5O4/c1-14-2-7-19(25)20(10-14)29-24(32)28-16-3-5-17(6-4-16)34-18-8-9-26-22(12-18)21-11-15(13-27-21)23(31)30-33/h2-13,27,33H,1H3,(H,30,31)(H2,28,29,32)
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n/an/a 14n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110637
PNG
(US8614234, 105 | US9725433, 105)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C30H31FN6O3/c1-20-4-9-25(31)26(16-20)36-30(39)35-22-5-7-23(8-6-22)40-24-10-11-32-28(18-24)27-17-21(19-34-27)29(38)33-12-15-37-13-2-3-14-37/h4-11,16-19,34H,2-3,12-15H2,1H3,(H,33,38)(H2,35,36,39)
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110647
PNG
(US8614234, 115 | US9725433, 115)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H20N4O4/c1-15-3-2-4-18(11-15)28-24(31)27-17-5-7-19(8-6-17)32-20-9-10-25-22(13-20)21-12-16(14-26-21)23(29)30/h2-14,26H,1H3,(H,29,30)(H2,27,28,31)
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM330359
PNG
(N-ethyl-5-(4-{3-[(3- methyl-2- furoyl)amino]phenox...)
Show SMILES CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C24H22N4O4/c1-3-25-23(29)16-11-20(27-14-16)21-13-19(7-9-26-21)32-18-6-4-5-17(12-18)28-24(30)22-15(2)8-10-31-22/h4-14,27H,3H2,1-2H3,(H,25,29)(H,28,30)
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110597
PNG
(US8614234, 65 | US9725433, 65)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(C3)C(O)=O)cc2F)c1
Show InChI InChI=1S/C29H25F2N5O5/c1-16-2-4-21(30)24(10-16)35-29(40)34-23-5-3-19(12-22(23)31)41-20-6-8-32-26(13-20)25-11-18(14-33-25)27(37)36-9-7-17(15-36)28(38)39/h2-6,8,10-14,17,33H,7,9,15H2,1H3,(H,38,39)(H2,34,35,40)
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110604
PNG
(US8614234, 72 | US9725433, 72)
Show SMILES COC(=O)CNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C27H24FN5O5/c1-16-4-3-5-18(10-16)32-27(36)33-22-7-6-19(12-21(22)28)38-20-8-9-29-24(13-20)23-11-17(14-30-23)26(35)31-15-25(34)37-2/h3-14,30H,15H2,1-2H3,(H,31,35)(H2,32,33,36)
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110610
PNG
(US8614234, 78 | US9725433, 78)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2)c1
Show InChI InChI=1S/C28H26FN5O5/c1-17-4-9-22(29)23(13-17)34-28(38)33-19-5-7-20(8-6-19)39-21-10-12-30-25(15-21)24-14-18(16-32-24)27(37)31-11-2-3-26(35)36/h4-10,12-16,32H,2-3,11H2,1H3,(H,31,37)(H,35,36)(H2,33,34,38)
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110664
PNG
(US8614234, 132 | US9725433, 132)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CC[C@@H](O)C3)cc2)c1
Show InChI InChI=1S/C28H26FN5O4/c1-17-2-7-23(29)24(12-17)33-28(37)32-19-3-5-21(6-4-19)38-22-8-10-30-26(14-22)25-13-18(15-31-25)27(36)34-11-9-20(35)16-34/h2-8,10,12-15,20,31,35H,9,11,16H2,1H3,(H2,32,33,37)/t20-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110665
PNG
(US8614234, 133 | US9725433, 133)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CC[C@H](O)C3)cc2)c1
Show InChI InChI=1S/C28H26FN5O4/c1-17-2-7-23(29)24(12-17)33-28(37)32-19-3-5-21(6-4-19)38-22-8-10-30-26(14-22)25-13-18(15-31-25)27(36)34-11-9-20(35)16-34/h2-8,10,12-15,20,31,35H,9,11,16H2,1H3,(H2,32,33,37)/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110575
PNG
(US8614234, 43 | US9725433, 43)
Show SMILES CCNC(=O)[C@H](CCC(O)=O)NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C31H31FN6O6/c1-3-33-30(42)25(9-10-28(39)40)37-29(41)19-14-26(35-17-19)27-16-22(11-12-34-27)44-21-7-8-24(23(32)15-21)38-31(43)36-20-6-4-5-18(2)13-20/h4-8,11-17,25,35H,3,9-10H2,1-2H3,(H,33,42)(H,37,41)(H,39,40)(H2,36,38,43)/t25-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110583
PNG
(US8614234, 51 | US9725433, 51)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(=O)N3CC[C@H](O)C3)cc2)c1
Show InChI InChI=1S/C30H29FN6O5/c1-18-2-7-24(31)25(12-18)36-30(41)35-20-3-5-22(6-4-20)42-23-8-10-32-27(14-23)26-13-19(15-33-26)29(40)34-16-28(39)37-11-9-21(38)17-37/h2-8,10,12-15,21,33,38H,9,11,16-17H2,1H3,(H,34,40)(H2,35,36,41)/t21-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110662
PNG
(US8614234, 130 | US9725433, 130)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)OCC(O)CO)cc2)c1
Show InChI InChI=1S/C27H25FN4O6/c1-16-2-7-22(28)23(10-16)32-27(36)31-18-3-5-20(6-4-18)38-21-8-9-29-25(12-21)24-11-17(13-30-24)26(35)37-15-19(34)14-33/h2-13,19,30,33-34H,14-15H2,1H3,(H2,31,32,36)
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n/an/a 16n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110600
PNG
(US8614234, 68 | US9725433, 68)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C28H26FN5O5/c1-17-4-2-5-19(12-17)33-28(38)34-23-8-7-20(14-22(23)29)39-21-9-11-30-25(15-21)24-13-18(16-32-24)27(37)31-10-3-6-26(35)36/h2,4-5,7-9,11-16,32H,3,6,10H2,1H3,(H,31,37)(H,35,36)(H2,33,34,38)
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n/an/a 16n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110577
PNG
(US8614234, 45 | US9725433, 45)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(O)=O)cc2F)c1
Show InChI InChI=1S/C33H34FN5O7/c1-19-6-5-7-21(14-19)37-32(44)39-25-9-8-22(16-24(25)34)45-23-12-13-35-28(17-23)27-15-20(18-36-27)30(41)38-26(31(42)43)10-11-29(40)46-33(2,3)4/h5-9,12-18,26,36H,10-11H2,1-4H3,(H,38,41)(H,42,43)(H2,37,39,44)/t26-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110598
PNG
(US8614234, 66 | US9725433, 66)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39)
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n/an/a 17n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110648
PNG
(US8614234, 116 | US9725433, 116)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)cc2)ccn1
Show InChI InChI=1S/C25H22N4O4/c1-16-4-3-5-19(12-16)29-25(31)28-18-6-8-20(9-7-18)33-21-10-11-26-23(14-21)22-13-17(15-27-22)24(30)32-2/h3-15,27H,1-2H3,(H2,28,29,31)
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n/an/a 17n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110622
PNG
(US8614234, 90 | US9725433, 90)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC[C@@H](O)C3)cc2)c1
Show InChI InChI=1S/C29H29N5O4/c1-19-4-2-5-22(14-19)33-29(37)32-21-7-9-24(10-8-21)38-25-11-12-30-27(16-25)26-15-20(17-31-26)28(36)34-13-3-6-23(35)18-34/h2,4-5,7-12,14-17,23,31,35H,3,6,13,18H2,1H3,(H2,32,33,37)/t23-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110579
PNG
(US8614234, 47 | US9725433, 47)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N[C@@H](CCC(=O)OCCO)C(=O)OCCO)cc2F)c1
Show InChI InChI=1S/C33H34FN5O9/c1-20-3-2-4-22(15-20)37-33(45)39-26-6-5-23(17-25(26)34)48-24-9-10-35-29(18-24)28-16-21(19-36-28)31(43)38-27(32(44)47-14-12-41)7-8-30(42)46-13-11-40/h2-6,9-10,15-19,27,36,40-41H,7-8,11-14H2,1H3,(H,38,43)(H2,37,39,45)/t27-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110628
PNG
(US8614234, 96 | US9725433, 96)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2F)c1
Show InChI InChI=1S/C24H18F2N4O4/c1-13-2-4-17(25)20(8-13)30-24(33)29-19-5-3-15(10-18(19)26)34-16-6-7-27-22(11-16)21-9-14(12-28-21)23(31)32/h2-12,28H,1H3,(H,31,32)(H2,29,30,33)
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n/an/a 17n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110649
PNG
(US8614234, 117 | US9725433, 117)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)c(F)c2)c1
Show InChI InChI=1S/C24H18F2N4O4/c1-13-2-4-17(25)19(8-13)30-24(33)29-15-3-5-22(18(26)10-15)34-16-6-7-27-21(11-16)20-9-14(12-28-20)23(31)32/h2-12,28H,1H3,(H,31,32)(H2,29,30,33)
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n/an/a 18n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330441
PNG
(N-[dimethyl(oxido)-lambda~4~- sulfanylidene]-5-{4-...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N=S(C)(C)=O)c2)c1
Show InChI InChI=1S/C26H25N5O4S/c1-17-6-4-7-19(12-17)29-26(33)30-20-8-5-9-21(14-20)35-22-10-11-27-24(15-22)23-13-18(16-28-23)25(32)31-36(2,3)34/h4-16,28H,1-3H3,(H2,29,30,33)
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n/an/a 18n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110644
PNG
(US8614234, 112 | US9725433, 112)
Show SMILES CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C26H24FN5O3/c1-3-28-25(33)17-13-23(30-15-17)24-14-20(10-11-29-24)35-19-7-5-18(6-8-19)31-26(34)32-22-12-16(2)4-9-21(22)27/h4-15,30H,3H2,1-2H3,(H,28,33)(H2,31,32,34)
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n/an/a 18n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110613
PNG
(US8614234, 81 | US9725433, 81)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCC(O)=O)cc2)c1
Show InChI InChI=1S/C27H24FN5O5/c1-16-2-7-21(28)22(12-16)33-27(37)32-18-3-5-19(6-4-18)38-20-8-10-29-24(14-20)23-13-17(15-31-23)26(36)30-11-9-25(34)35/h2-8,10,12-15,31H,9,11H2,1H3,(H,30,36)(H,34,35)(H2,32,33,37)
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n/an/a 19n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330426
PNG
(4-{S-methyl-N-[(5-{4-[4-({[(3- methylphenyl)amino]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N=S(C)(=O)CCCC(O)=O)cc2)c1
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n/an/a 19n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110549
PNG
(US8614234, 17 | US9725433, 17)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)NO)c1
Show InChI InChI=1S/C22H18N4O5/c1-13-6-8-30-20(13)22(28)25-15-3-2-4-16(10-15)31-17-5-7-23-19(11-17)18-9-14(12-24-18)21(27)26-29/h2-12,24,29H,1H3,(H,25,28)(H,26,27)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110653
PNG
(US8614234, 121 | US9725433, 121)
Show SMILES OC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C24H16ClF3N4O4/c25-19-6-3-15(10-18(19)24(26,27)28)32-23(35)31-14-1-4-16(5-2-14)36-17-7-8-29-21(11-17)20-9-13(12-30-20)22(33)34/h1-12,30H,(H,33,34)(H2,31,32,35)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110602
PNG
(US8614234, 70 | US9725433, 70)
Show SMILES CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C26H24FN5O3/c1-3-28-25(33)17-12-23(30-15-17)24-14-20(9-10-29-24)35-19-7-8-22(21(27)13-19)32-26(34)31-18-6-4-5-16(2)11-18/h4-15,30H,3H2,1-2H3,(H,28,33)(H2,31,32,34)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110603
PNG
(US8614234, 71 | US9725433, 71)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(O)=O)cc2F)c1
Show InChI InChI=1S/C26H22FN5O5/c1-15-3-2-4-17(9-15)31-26(36)32-21-6-5-18(11-20(21)27)37-19-7-8-28-23(12-19)22-10-16(13-29-22)25(35)30-14-24(33)34/h2-13,29H,14H2,1H3,(H,30,35)(H,33,34)(H2,31,32,36)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110588
PNG
(US8614234, 56 | US9725433, 56)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(=O)NCC(O)CO)cc2)c1
Show InChI InChI=1S/C29H29FN6O6/c1-17-2-7-23(30)24(10-17)36-29(41)35-19-3-5-21(6-4-19)42-22-8-9-31-26(12-22)25-11-18(13-32-25)28(40)34-15-27(39)33-14-20(38)16-37/h2-13,20,32,37-38H,14-16H2,1H3,(H,33,39)(H,34,40)(H2,35,36,41)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110635
PNG
(US8614234, 103 | US9725433, 103)
Show SMILES CCN(CC)C(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C28H28FN5O3/c1-4-34(5-2)27(35)19-15-25(31-17-19)26-16-22(12-13-30-26)37-21-9-7-20(8-10-21)32-28(36)33-24-14-18(3)6-11-23(24)29/h6-17,31H,4-5H2,1-3H3,(H2,32,33,36)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110563
PNG
(US8614234, 31 | US9725433, 31)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)N2CC[C@H](O)C2)c1
Show InChI InChI=1S/C26H24N4O5/c1-16-7-10-34-24(16)25(32)29-18-3-2-4-20(12-18)35-21-5-8-27-23(13-21)22-11-17(14-28-22)26(33)30-9-6-19(31)15-30/h2-5,7-8,10-14,19,28,31H,6,9,15H2,1H3,(H,29,32)/t19-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110638
PNG
(US8614234, 106 | US9725433, 106)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CC3)cc2)c1
Show InChI InChI=1S/C26H22FN5O3/c1-16-2-7-21(27)22(12-16)31-26(34)30-18-3-5-19(6-4-18)35-20-8-9-28-24(14-20)23-13-17(15-29-23)25(33)32-10-11-32/h2-9,12-15,29H,10-11H2,1H3,(H2,30,31,34)
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n/an/a 21n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110548
PNG
(US8614234, 16 | US9725433, 16)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(N)=O)c1
Show InChI InChI=1S/C22H18N4O4/c1-13-6-8-29-20(13)22(28)26-15-3-2-4-16(10-15)30-17-5-7-24-19(11-17)18-9-14(12-25-18)21(23)27/h2-12,25H,1H3,(H2,23,27)(H,26,28)
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n/an/a 21n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110639
PNG
(US8614234, 107 | US9725433, 107)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(N)=O)cc2)c1
Show InChI InChI=1S/C24H20FN5O3/c1-14-2-7-19(25)20(10-14)30-24(32)29-16-3-5-17(6-4-16)33-18-8-9-27-22(12-18)21-11-15(13-28-21)23(26)31/h2-13,28H,1H3,(H2,26,31)(H2,29,30,32)
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n/an/a 21n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110659
PNG
(US8614234, 127 | US9725433, 127)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(O)CO)cc2)c1
Show InChI InChI=1S/C27H26FN5O5/c1-16-2-7-22(28)23(10-16)33-27(37)32-18-3-5-20(6-4-18)38-21-8-9-29-25(12-21)24-11-17(13-30-24)26(36)31-14-19(35)15-34/h2-13,19,30,34-35H,14-15H2,1H3,(H,31,36)(H2,32,33,37)
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n/an/a 21n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110668
PNG
(US8614234, 136 | US9725433, 136)
Show SMILES COC(=O)c1cc(c[nH]1)-c1cc(Oc2cccc(NC(=O)Nc3cc(C)ccc3F)c2)ccn1
Show InChI InChI=1S/C25H21FN4O4/c1-15-6-7-20(26)22(10-15)30-25(32)29-17-4-3-5-18(12-17)34-19-8-9-27-21(13-19)16-11-23(28-14-16)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32)
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n/an/a 22n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110615
PNG
(US8614234, 83 | US9725433, 83)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(C3)C(O)=O)cc2)c1
Show InChI InChI=1S/C29H26FN5O5/c1-17-2-7-23(30)24(12-17)34-29(39)33-20-3-5-21(6-4-20)40-22-8-10-31-26(14-22)25-13-19(15-32-25)27(36)35-11-9-18(16-35)28(37)38/h2-8,10,12-15,18,32H,9,11,16H2,1H3,(H,37,38)(H2,33,34,39)
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n/an/a 22n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110646
PNG
(US8614234, 114 | US9725433, 114)
Show SMILES COCCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C27H26FN5O4/c1-17-3-8-22(28)23(13-17)33-27(35)32-19-4-6-20(7-5-19)37-21-9-10-29-25(15-21)24-14-18(16-31-24)26(34)30-11-12-36-2/h3-10,13-16,31H,11-12H2,1-2H3,(H,30,34)(H2,32,33,35)
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n/an/a 22n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110571
PNG
(US8614234, 39 | US9725433, 39)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)cc2F)c1
Show InChI InChI=1S/C24H19F2N5O4/c1-13-2-4-17(25)20(8-13)30-24(33)29-19-5-3-15(10-18(19)26)35-16-6-7-27-22(11-16)21-9-14(12-28-21)23(32)31-34/h2-12,28,34H,1H3,(H,31,32)(H2,29,30,33)
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n/an/a 23n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110543
PNG
(US8614234, 11 | US9725433, 11)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)c2)c1
Show InChI InChI=1S/C24H19FN4O4/c1-14-5-6-19(25)20(9-14)28-23(30)15-3-2-4-17(10-15)33-18-7-8-26-22(12-18)21-11-16(13-27-21)24(31)29-32/h2-13,27,32H,1H3,(H,28,30)(H,29,31)
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n/an/a 23n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110587
PNG
(US8614234, 55 | US9725433, 55)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(N)=O)cc2)c1
Show InChI InChI=1S/C28H27FN6O4/c1-17-4-9-22(29)23(13-17)35-28(38)34-19-5-7-20(8-6-19)39-21-10-12-31-25(15-21)24-14-18(16-33-24)27(37)32-11-2-3-26(30)36/h4-10,12-16,33H,2-3,11H2,1H3,(H2,30,36)(H,32,37)(H2,34,35,38)
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n/an/a 23n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110621
PNG
(US8614234, 89 | US9725433, 89)
Show SMILES CNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)cc2)ccn1
Show InChI InChI=1S/C25H23N5O3/c1-16-4-3-5-19(12-16)30-25(32)29-18-6-8-20(9-7-18)33-21-10-11-27-23(14-21)22-13-17(15-28-22)24(31)26-2/h3-15,28H,1-2H3,(H,26,31)(H2,29,30,32)
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n/an/a 23n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110592
PNG
(US8614234, 60 | US9725433, 60)
Show SMILES CCNC(=O)CCCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C30H31FN6O4/c1-3-32-28(38)5-4-13-34-29(39)20-16-26(35-18-20)27-17-23(12-14-33-27)41-22-9-7-21(8-10-22)36-30(40)37-25-15-19(2)6-11-24(25)31/h6-12,14-18,35H,3-5,13H2,1-2H3,(H,32,38)(H,34,39)(H2,36,37,40)
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n/an/a 23n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110641
PNG
(US8614234, 109 | US9725433, 109)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC3)cc2)c1
Show InChI InChI=1S/C27H24FN5O3/c1-17-3-8-22(28)23(13-17)32-27(35)31-19-4-6-20(7-5-19)36-21-9-10-29-25(15-21)24-14-18(16-30-24)26(34)33-11-2-12-33/h3-10,13-16,30H,2,11-12H2,1H3,(H2,31,32,35)
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n/an/a 23n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110556
PNG
(US8614234, 24 | US9725433, 24)
Show SMILES Cc1ccsc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)OCCO)c1
Show InChI InChI=1S/C24H21N3O5S/c1-15-6-10-33-22(15)23(29)27-17-3-2-4-18(12-17)32-19-5-7-25-21(13-19)20-11-16(14-26-20)24(30)31-9-8-28/h2-7,10-14,26,28H,8-9H2,1H3,(H,27,29)
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n/an/a 24n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110601
PNG
(US8614234, 69 | US9725433, 69)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C27H23F2N5O5/c1-15-2-4-19(28)22(10-15)34-27(38)33-21-5-3-17(12-20(21)29)39-18-6-8-30-24(13-18)23-11-16(14-32-23)26(37)31-9-7-25(35)36/h2-6,8,10-14,32H,7,9H2,1H3,(H,31,37)(H,35,36)(H2,33,34,38)
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n/an/a 24n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110655
PNG
(US8614234, 123 | US9725433, 123)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3csc(c3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H18FN3O4S/c1-14-2-7-19(25)21(10-14)28-24(31)27-16-3-5-17(6-4-16)32-18-8-9-26-20(12-18)15-11-22(23(29)30)33-13-15/h2-13H,1H3,(H,29,30)(H2,27,28,31)
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Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110553
PNG
(US8614234, 21 | US9725433, 21)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)OCC(O)CO)c1
Show InChI InChI=1S/C25H23N3O7/c1-15-6-8-33-23(15)24(31)28-17-3-2-4-19(10-17)35-20-5-7-26-22(11-20)21-9-16(12-27-21)25(32)34-14-18(30)13-29/h2-12,18,27,29-30H,13-14H2,1H3,(H,28,31)
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Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110576
PNG
(US8614234, 44 | US9725433, 44)
Show SMILES CCNC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C35H39FN6O6/c1-6-37-33(45)28(12-13-31(43)48-35(3,4)5)41-32(44)22-17-29(39-20-22)30-19-25(14-15-38-30)47-24-10-11-27(26(36)18-24)42-34(46)40-23-9-7-8-21(2)16-23/h7-11,14-20,28,39H,6,12-13H2,1-5H3,(H,37,45)(H,41,44)(H2,40,42,46)/t28-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110584
PNG
(US8614234, 52 | US9725433, 52)
Show SMILES CN(CC(O)CO)C(=O)CCCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C32H35FN6O6/c1-20-5-10-26(33)27(14-20)38-32(44)37-22-6-8-24(9-7-22)45-25-11-13-34-29(16-25)28-15-21(17-36-28)31(43)35-12-3-4-30(42)39(2)18-23(41)19-40/h5-11,13-17,23,36,40-41H,3-4,12,18-19H2,1-2H3,(H,35,43)(H2,37,38,44)
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n/an/a 25n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110645
PNG
(US8614234, 113 | US9725433, 113)
Show SMILES COCCOC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C27H25FN4O5/c1-17-3-8-22(28)23(13-17)32-27(34)31-19-4-6-20(7-5-19)37-21-9-10-29-25(15-21)24-14-18(16-30-24)26(33)36-12-11-35-2/h3-10,13-16,30H,11-12H2,1-2H3,(H2,31,32,34)
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n/an/a 25n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330431
PNG
(US9725433, 87 | methyl 4-{S-methyl-N-[(5-{4- [4-({...)
Show SMILES COC(=O)CCCS(C)(=O)=NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)cc2)ccn1
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n/an/a 25n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110557
PNG
(US8614234, 25 | US9725433, 25)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)OCCO)c1
Show InChI InChI=1S/C24H21N3O6/c1-15-6-9-31-22(15)23(29)27-17-3-2-4-18(12-17)33-19-5-7-25-21(13-19)20-11-16(14-26-20)24(30)32-10-8-28/h2-7,9,11-14,26,28H,8,10H2,1H3,(H,27,29)
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n/an/a 25n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110547
PNG
(US8614234, 15 | US9725433, 15)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)NCC(O)CO)c1
Show InChI InChI=1S/C25H24N4O6/c1-15-6-8-34-23(15)25(33)29-17-3-2-4-19(10-17)35-20-5-7-26-22(11-20)21-9-16(12-27-21)24(32)28-13-18(31)14-30/h2-12,18,27,30-31H,13-14H2,1H3,(H,28,32)(H,29,33)
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n/an/a 26n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110676
PNG
(US8614234, 144 | US9725433, 144)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ccc[nH]3)cc2)c1
Show InChI InChI=1S/C23H19FN4O2/c1-15-4-9-19(24)21(13-15)28-23(29)27-16-5-7-17(8-6-16)30-18-10-12-26-22(14-18)20-3-2-11-25-20/h2-14,25H,1H3,(H2,27,28,29)
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n/an/a 26n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330448
PNG
(1-(2-fluoro-5-methylphenyl)-3- {4-[(2-{4-[(4-methy...)
Show SMILES CN1CCN(CC1)C(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)cc2)ccn1
Show InChI InChI=1S/C29H30N6O3/c1-20-4-3-5-23(16-20)33-29(37)32-22-6-8-24(9-7-22)38-25-10-11-30-27(18-25)26-17-21(19-31-26)28(36)35-14-12-34(2)13-15-35/h3-11,16-19,31H,12-15H2,1-2H3,(H2,32,33,37)
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n/an/a 27n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110545
PNG
(US8614234, 13 | US9725433, 13)
Show SMILES Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)c2)c1
Show InChI InChI=1S/C24H17F2N3O4/c1-13-2-4-17(25)19(8-13)29-23(30)14-3-5-18(26)22(10-14)33-16-6-7-27-21(11-16)20-9-15(12-28-20)24(31)32/h2-12,28H,1H3,(H,29,30)(H,31,32)
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n/an/a 27n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110618
PNG
(US8614234, 86 | US9725433, 86)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(CC3)S(O)(=O)=O)cc2)c1
Show InChI InChI=1S/C29H28FN5O6S/c1-18-2-7-24(30)25(14-18)34-29(37)33-20-3-5-21(6-4-20)41-22-8-11-31-27(16-22)26-15-19(17-32-26)28(36)35-12-9-23(10-13-35)42(38,39)40/h2-8,11,14-17,23,32H,9-10,12-13H2,1H3,(H2,33,34,37)(H,38,39,40)
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n/an/a 27n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110581
PNG
(US8614234, 49 | US9725433, 49)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2F)c1
Show InChI InChI=1S/C29H26FN5O7/c1-16-3-2-4-18(11-16)33-29(41)35-22-6-5-19(13-21(22)30)42-20-9-10-31-25(14-20)24-12-17(15-32-24)27(38)34-23(28(39)40)7-8-26(36)37/h2-6,9-15,23,32H,7-8H2,1H3,(H,34,38)(H,36,37)(H,39,40)(H2,33,35,41)/t23-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110534
PNG
(US8614234, 2 | US9725433, 2)
Show SMILES COC(=O)CNC(=O)c1c[nH]c(c1)-c1cc(Oc2cc(ccc2F)C(=O)Nc2cc(C)ccc2F)ccn1
Show InChI InChI=1S/C27H22F2N4O5/c1-15-3-5-19(28)21(9-15)33-27(36)16-4-6-20(29)24(11-16)38-18-7-8-30-23(12-18)22-10-17(13-31-22)26(35)32-14-25(34)37-2/h3-13,31H,14H2,1-2H3,(H,32,35)(H,33,36)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110552
PNG
(US8614234, 20 | US9725433, 20)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(c2)C(=O)Nc2cc(C)ccc2F)ccn1
Show InChI InChI=1S/C25H20FN3O4/c1-15-6-7-20(26)21(10-15)29-24(30)16-4-3-5-18(11-16)33-19-8-9-27-23(13-19)22-12-17(14-28-22)25(31)32-2/h3-14,28H,1-2H3,(H,29,30)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110533
PNG
(US8614234, 1 | US9725433, 1)
Show SMILES Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(O)=O)c2)c1
Show InChI InChI=1S/C26H20F2N4O5/c1-14-2-4-18(27)20(8-14)32-26(36)15-3-5-19(28)23(10-15)37-17-6-7-29-22(11-17)21-9-16(12-30-21)25(35)31-13-24(33)34/h2-12,30H,13H2,1H3,(H,31,35)(H,32,36)(H,33,34)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110540
PNG
(US8614234, 8 | US9725433, 8)
Show SMILES Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCCC(O)C3)c2)c1
Show InChI InChI=1S/C29H26F2N4O4/c1-17-4-6-22(30)24(11-17)34-28(37)18-5-7-23(31)27(13-18)39-21-8-9-32-26(14-21)25-12-19(15-33-25)29(38)35-10-2-3-20(36)16-35/h4-9,11-15,20,33,36H,2-3,10,16H2,1H3,(H,34,37)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110674
PNG
(US8614234, 142 | US9725433, 142)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3c[nH]c(c3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H19FN4O4/c1-14-2-7-19(25)21(10-14)29-24(32)28-16-3-5-17(6-4-16)33-18-8-9-26-20(12-18)15-11-22(23(30)31)27-13-15/h2-13,27H,1H3,(H,30,31)(H2,28,29,32)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110535
PNG
(US8614234, 3 | US9725433, 3)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)NCC(O)=O)c1
Show InChI InChI=1S/C24H20N4O6/c1-14-6-8-33-22(14)24(32)28-16-3-2-4-17(10-16)34-18-5-7-25-20(11-18)19-9-15(12-26-19)23(31)27-13-21(29)30/h2-12,26H,13H2,1H3,(H,27,31)(H,28,32)(H,29,30)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110585
PNG
(US8614234, 53 | US9725433, 53)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(=O)N3CCCC(O)C3)cc2)c1
Show InChI InChI=1S/C33H35FN6O5/c1-21-6-11-27(34)28(16-21)39-33(44)38-23-7-9-25(10-8-23)45-26-12-14-35-30(18-26)29-17-22(19-37-29)32(43)36-13-2-5-31(42)40-15-3-4-24(41)20-40/h6-12,14,16-19,24,37,41H,2-5,13,15,20H2,1H3,(H,36,43)(H2,38,39,44)
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110578
PNG
(US8614234, 46 | US9725433, 46)
Show SMILES COC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1
Show InChI InChI=1S/C34H36FN5O7/c1-20-7-6-8-22(15-20)38-33(44)40-26-10-9-23(17-25(26)35)46-24-13-14-36-29(18-24)28-16-21(19-37-28)31(42)39-27(32(43)45-5)11-12-30(41)47-34(2,3)4/h6-10,13-19,27,37H,11-12H2,1-5H3,(H,39,42)(H2,38,40,44)/t27-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110563
PNG
(US8614234, 31 | US9725433, 31)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)N2CC[C@H](O)C2)c1
Show InChI InChI=1S/C26H24N4O5/c1-16-7-10-34-24(16)25(32)29-18-3-2-4-20(12-18)35-21-5-8-27-23(13-21)22-11-17(14-28-22)26(33)30-9-6-19(31)15-30/h2-5,7-8,10-14,19,28,31H,6,9,15H2,1H3,(H,29,32)/t19-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110586
PNG
(US8614234, 54 | US9725433, 54)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(=O)NCC(O)CO)cc2)c1
Show InChI InChI=1S/C31H33FN6O6/c1-19-4-9-25(32)26(13-19)38-31(43)37-21-5-7-23(8-6-21)44-24-10-12-33-28(15-24)27-14-20(16-35-27)30(42)34-11-2-3-29(41)36-17-22(40)18-39/h4-10,12-16,22,35,39-40H,2-3,11,17-18H2,1H3,(H,34,42)(H,36,41)(H2,37,38,43)
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n/an/a 29n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110554
PNG
(US8614234, 22 | US9725433, 22)
Show SMILES Cc1cccc(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)c2)c1
Show InChI InChI=1S/C24H19N3O4/c1-15-4-2-6-18(10-15)27-23(28)16-5-3-7-19(11-16)31-20-8-9-25-22(13-20)21-12-17(14-26-21)24(29)30/h2-14,26H,1H3,(H,27,28)(H,29,30)
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n/an/a 29n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110591
PNG
(US8614234, 59 | US9725433, 59)
Show SMILES COC(=O)[C@H](CCC(O)=O)NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C30H28FN5O7/c1-17-3-8-22(31)24(13-17)36-30(41)34-19-4-6-20(7-5-19)43-21-11-12-32-26(15-21)25-14-18(16-33-25)28(39)35-23(29(40)42-2)9-10-27(37)38/h3-8,11-16,23,33H,9-10H2,1-2H3,(H,35,39)(H,37,38)(H2,34,36,41)/t23-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330380
PNG
(US9725433, 35 | methyl 4-(4-{3-[(3-methyl- 2-furoy...)
Show SMILES COC(=O)c1cc(c[nH]1)-c1cc(Oc2cccc(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C23H19N3O5/c1-14-7-9-30-21(14)22(27)26-16-4-3-5-17(11-16)31-18-6-8-24-19(12-18)15-10-20(25-13-15)23(28)29-2/h3-13,25H,1-2H3,(H,26,27)
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n/an/a 29n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110536
PNG
(US8614234, 4 | US9725433, 4)
Show SMILES COC(=O)CNC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C25H22N4O6/c1-15-7-9-34-23(15)25(32)29-17-4-3-5-18(11-17)35-19-6-8-26-21(12-19)20-10-16(13-27-20)24(31)28-14-22(30)33-2/h3-13,27H,14H2,1-2H3,(H,28,31)(H,29,32)
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n/an/a 29n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110671
PNG
(US8614234, 139 | US9725433, 139)
Show SMILES CNC(=O)c1cc(c[nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C25H22FN5O3/c1-15-3-8-20(26)22(11-15)31-25(33)30-17-4-6-18(7-5-17)34-19-9-10-28-21(13-19)16-12-23(29-14-16)24(32)27-2/h3-14,29H,1-2H3,(H,27,32)(H2,30,31,33)
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n/an/a 30n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110595
PNG
(US8614234, 63 | US9725433, 63)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2)c1
Show InChI InChI=1S/C29H26FN5O7/c1-16-2-7-21(30)23(12-16)35-29(41)33-18-3-5-19(6-4-18)42-20-10-11-31-25(14-20)24-13-17(15-32-24)27(38)34-22(28(39)40)8-9-26(36)37/h2-7,10-15,22,32H,8-9H2,1H3,(H,34,38)(H,36,37)(H,39,40)(H2,33,35,41)/t22-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110617
PNG
(US8614234, 85 | US9725433, 85)
Show SMILES COC(=O)CNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C27H24FN5O5/c1-16-3-8-21(28)22(11-16)33-27(36)32-18-4-6-19(7-5-18)38-20-9-10-29-24(13-20)23-12-17(14-30-23)26(35)31-15-25(34)37-2/h3-14,30H,15H2,1-2H3,(H,31,35)(H2,32,33,36)
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n/an/a 30n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110670
PNG
(US8614234, 138 | US9725433, 138)
Show SMILES CN(C)C(=O)c1cc(c[nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C26H24FN5O3/c1-16-4-9-21(27)23(12-16)31-26(34)30-18-5-7-19(8-6-18)35-20-10-11-28-22(14-20)17-13-24(29-15-17)25(33)32(2)3/h4-15,29H,1-3H3,(H2,30,31,34)
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n/an/a 30n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110657
PNG
(US8614234, 125 | US9725433, 125)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(CC(O)=O)CC3)cc2)c1
Show InChI InChI=1S/C31H30FN5O5/c1-19-2-7-25(32)26(14-19)36-31(41)35-22-3-5-23(6-4-22)42-24-8-11-33-28(17-24)27-16-21(18-34-27)30(40)37-12-9-20(10-13-37)15-29(38)39/h2-8,11,14,16-18,20,34H,9-10,12-13,15H2,1H3,(H,38,39)(H2,35,36,41)
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n/an/a 31n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110663
PNG
(US8614234, 131 | US9725433, 131)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)OCCO)cc2)c1
Show InChI InChI=1S/C26H23FN4O5/c1-16-2-7-21(27)22(12-16)31-26(34)30-18-3-5-19(6-4-18)36-20-8-9-28-24(14-20)23-13-17(15-29-23)25(33)35-11-10-32/h2-9,12-15,29,32H,10-11H2,1H3,(H2,30,31,34)
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n/an/a 31n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110599
PNG
(US8614234, 67 | US9725433, 67)
Show SMILES CCOC(=O)CCCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)c(F)c2)ccn1
Show InChI InChI=1S/C30H29F2N5O5/c1-3-41-28(38)5-4-11-34-29(39)19-14-26(35-17-19)27-16-21(10-12-33-27)42-20-7-9-24(23(32)15-20)36-30(40)37-25-13-18(2)6-8-22(25)31/h6-10,12-17,35H,3-5,11H2,1-2H3,(H,34,39)(H2,36,37,40)
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Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110550
PNG
(US8614234, 18 | US9725433, 18)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)N2CC[C@@H](O)C2)c1
Show InChI InChI=1S/C26H24N4O5/c1-16-7-10-34-24(16)25(32)29-18-3-2-4-20(12-18)35-21-5-8-27-23(13-21)22-11-17(14-28-22)26(33)30-9-6-19(31)15-30/h2-5,7-8,10-14,19,28,31H,6,9,15H2,1H3,(H,29,32)/t19-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110666
PNG
(US8614234, 134 | US9725433, 134)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H19FN4O4/c1-14-2-7-19(25)20(10-14)29-24(32)28-16-3-5-17(6-4-16)33-18-8-9-26-22(12-18)21-11-15(13-27-21)23(30)31/h2-13,27H,1H3,(H,30,31)(H2,28,29,32)
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n/an/a 31n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110582
PNG
(US8614234, 50 | US9725433, 50)
Show SMILES COC(=O)C1CCCN1CCCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C33H35FN6O5/c1-21-6-11-26(34)27(17-21)39-33(43)38-23-7-9-24(10-8-23)45-25-12-14-35-29(19-25)28-18-22(20-37-28)31(41)36-13-4-16-40-15-3-5-30(40)32(42)44-2/h6-12,14,17-20,30,37H,3-5,13,15-16H2,1-2H3,(H,36,41)(H2,38,39,43)
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n/an/a 32n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110627
PNG
(US8614234, 95 | US9725433, 95)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)cc2)c1
Show InChI InChI=1S/C24H21N5O4/c1-15-3-2-4-18(11-15)28-24(31)27-17-5-7-19(8-6-17)33-20-9-10-25-22(13-20)21-12-16(14-26-21)23(30)29-32/h2-14,26,32H,1H3,(H,29,30)(H2,27,28,31)
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n/an/a 32n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330359
PNG
(N-ethyl-5-(4-{3-[(3- methyl-2- furoyl)amino]phenox...)
Show SMILES CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C24H22N4O4/c1-3-25-23(29)16-11-20(27-14-16)21-13-19(7-9-26-21)32-18-6-4-5-17(12-18)28-24(30)22-15(2)8-10-31-22/h4-14,27H,3H2,1-2H3,(H,25,29)(H,28,30)
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n/an/a 33n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330481
PNG
(N-[dimethyl(oxido)-lambda~4~- sulfanylidene]-4-{4-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3c[nH]c(c3)C(=O)N=S(C)(C)=O)cc2)c1
Show InChI InChI=1S/C26H24FN5O4S/c1-16-4-9-21(27)23(12-16)31-26(34)30-18-5-7-19(8-6-18)36-20-10-11-28-22(14-20)17-13-24(29-15-17)25(33)32-37(2,3)35/h4-15,29H,1-3H3,(H2,30,31,34)
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n/an/a 33n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM110543
PNG
(US8614234, 11 | US9725433, 11)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)c2)c1
Show InChI InChI=1S/C24H19FN4O4/c1-14-5-6-19(25)20(9-14)28-23(30)15-3-2-4-17(10-15)33-18-7-8-26-22(12-18)21-11-16(13-27-21)24(31)29-32/h2-13,27,32H,1H3,(H,28,30)(H,29,31)
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n/an/a 34n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110539
PNG
(US8614234, 7 | US9725433, 7)
Show SMILES Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NO)c2)c1
Show InChI InChI=1S/C24H18F2N4O4/c1-13-2-4-17(25)19(8-13)29-23(31)14-3-5-18(26)22(10-14)34-16-6-7-27-21(11-16)20-9-15(12-28-20)24(32)30-33/h2-12,28,33H,1H3,(H,29,31)(H,30,32)
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n/an/a 34n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110634
PNG
(US8614234, 102 | US9725433, 102)
Show SMILES COC(=O)[C@@H]1CCCN1CCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C32H33FN6O5/c1-20-5-10-25(33)26(16-20)38-32(42)37-22-6-8-23(9-7-22)44-24-11-12-34-28(18-24)27-17-21(19-36-27)30(40)35-13-15-39-14-3-4-29(39)31(41)43-2/h5-12,16-19,29,36H,3-4,13-15H2,1-2H3,(H,35,40)(H2,37,38,42)/t29-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110555
PNG
(US8614234, 23 | US9725433, 23)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(c2)C(=O)Nc2cccc(C)c2)ccn1
Show InChI InChI=1S/C25H21N3O4/c1-16-5-3-7-19(11-16)28-24(29)17-6-4-8-20(12-17)32-21-9-10-26-23(14-21)22-13-18(15-27-22)25(30)31-2/h3-15,27H,1-2H3,(H,28,29)
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n/an/a 35n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110590
PNG
(US8614234, 58 | US9725433, 58)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N[C@@H](CCC(=O)OCC(O)CO)C(=O)OCC(O)CO)cc2)c1
Show InChI InChI=1S/C35H38FN5O11/c1-20-2-7-27(36)29(12-20)41-35(49)39-22-3-5-25(6-4-22)52-26-10-11-37-31(14-26)30-13-21(15-38-30)33(47)40-28(34(48)51-19-24(45)17-43)8-9-32(46)50-18-23(44)16-42/h2-7,10-15,23-24,28,38,42-45H,8-9,16-19H2,1H3,(H,40,47)(H2,39,41,49)/t23?,24?,28-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110656
PNG
(US8614234, 124 | US9725433, 124)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3c[nH]c(c3)C(=O)OCCO)cc2)c1
Show InChI InChI=1S/C26H23FN4O5/c1-16-2-7-21(27)23(12-16)31-26(34)30-18-3-5-19(6-4-18)36-20-8-9-28-22(14-20)17-13-24(29-15-17)25(33)35-11-10-32/h2-9,12-15,29,32H,10-11H2,1H3,(H2,30,31,34)
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n/an/a 36n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330375
PNG
(N-[dimethyl(oxido)- lambda~4~-sulfanylidene]- 5-(4...)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H22N4O5S/c1-15-8-10-32-22(15)24(30)27-17-5-4-6-18(12-17)33-19-7-9-25-21(13-19)20-11-16(14-26-20)23(29)28-34(2,3)31/h4-14,26H,1-3H3,(H,27,30)
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n/an/a 37n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110551
PNG
(US8614234, 19 | US9725433, 19)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)c2)c1
Show InChI InChI=1S/C24H18FN3O4/c1-14-5-6-19(25)20(9-14)28-23(29)15-3-2-4-17(10-15)32-18-7-8-26-22(12-18)21-11-16(13-27-21)24(30)31/h2-13,27H,1H3,(H,28,29)(H,30,31)
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n/an/a 37n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110611
PNG
(US8614234, 79 | US9725433, 79)
Show SMILES CCOC(=O)CCCNC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C30H30FN5O5/c1-3-40-28(37)5-4-13-33-29(38)20-16-26(34-18-20)27-17-23(12-14-32-27)41-22-9-7-21(8-10-22)35-30(39)36-25-15-19(2)6-11-24(25)31/h6-12,14-18,34H,3-5,13H2,1-2H3,(H,33,38)(H2,35,36,39)
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n/an/a 38n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110642
PNG
(US8614234, 110 | US9725433, 110)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCO)cc2)c1
Show InChI InChI=1S/C27H26FN5O4/c1-17-3-8-22(28)23(13-17)33-27(36)32-19-4-6-20(7-5-19)37-21-9-11-29-25(15-21)24-14-18(16-31-24)26(35)30-10-2-12-34/h3-9,11,13-16,31,34H,2,10,12H2,1H3,(H,30,35)(H2,32,33,36)
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n/an/a 38n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110596
PNG
(US8614234, 64 | US9725433, 64)
Show SMILES COC(=O)CC[C@H](NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1)C(=O)OC
Show InChI InChI=1S/C31H30FN5O7/c1-18-4-9-23(32)25(14-18)37-31(41)35-20-5-7-21(8-6-20)44-22-12-13-33-27(16-22)26-15-19(17-34-26)29(39)36-24(30(40)43-3)10-11-28(38)42-2/h4-9,12-17,24,34H,10-11H2,1-3H3,(H,36,39)(H2,35,37,41)/t24-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110593
PNG
(US8614234, 61 | US9725433, 61)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(=O)N3CC[C@@H](O)C3)cc2)c1
Show InChI InChI=1S/C32H33FN6O5/c1-20-4-9-26(33)27(15-20)38-32(43)37-22-5-7-24(8-6-22)44-25-10-13-34-29(17-25)28-16-21(18-36-28)31(42)35-12-2-3-30(41)39-14-11-23(40)19-39/h4-10,13,15-18,23,36,40H,2-3,11-12,14,19H2,1H3,(H,35,42)(H2,37,38,43)/t23-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110542
PNG
(US8614234, 10 | US9725433, 10)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CC[C@H](O)C3)c2)c1
Show InChI InChI=1S/C28H25FN4O4/c1-17-5-6-23(29)24(11-17)32-27(35)18-3-2-4-21(12-18)37-22-7-9-30-26(14-22)25-13-19(15-31-25)28(36)33-10-8-20(34)16-33/h2-7,9,11-15,20,31,34H,8,10,16H2,1H3,(H,32,35)/t20-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110594
PNG
(US8614234, 62 | US9725433, 62)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(=O)NO)cc2)c1
Show InChI InChI=1S/C28H27FN6O5/c1-17-4-9-22(29)23(13-17)34-28(38)33-19-5-7-20(8-6-19)40-21-10-12-30-25(15-21)24-14-18(16-32-24)27(37)31-11-2-3-26(36)35-39/h4-10,12-16,32,39H,2-3,11H2,1H3,(H,31,37)(H,35,36)(H2,33,34,38)
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n/an/a 43n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110662
PNG
(US8614234, 130 | US9725433, 130)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)OCC(O)CO)cc2)c1
Show InChI InChI=1S/C27H25FN4O6/c1-16-2-7-22(28)23(10-16)32-27(36)31-18-3-5-20(6-4-18)38-21-8-9-29-25(12-21)24-11-17(13-30-24)26(35)37-15-19(34)14-33/h2-13,19,30,33-34H,14-15H2,1H3,(H2,31,32,36)
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n/an/a 43n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110589
PNG
(US8614234, 57 | US9725433, 57)
Show SMILES COC(=O)[C@H](CCC(=O)OCC(O)CO)NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C33H34FN5O9/c1-19-3-8-25(34)27(13-19)39-33(45)37-21-4-6-23(7-5-21)48-24-11-12-35-29(15-24)28-14-20(16-36-28)31(43)38-26(32(44)46-2)9-10-30(42)47-18-22(41)17-40/h3-8,11-16,22,26,36,40-41H,9-10,17-18H2,1-2H3,(H,38,43)(H2,37,39,45)/t22?,26-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110564
PNG
(US8614234, 32 | US9725433, 32)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(O)=O)c1
Show InChI InChI=1S/C22H17N3O5/c1-13-6-8-29-20(13)21(26)25-15-3-2-4-16(10-15)30-17-5-7-23-19(11-17)18-9-14(12-24-18)22(27)28/h2-12,24H,1H3,(H,25,26)(H,27,28)
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n/an/a 46n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM330443
PNG
(5-(4-{4-[({[4-chloro-3- (trifluoromethyl)phenyl]am...)
Show SMILES CS(C)(=O)=NC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C26H21ClF3N5O4S/c1-40(2,38)35-24(36)15-11-22(32-14-15)23-13-19(9-10-31-23)39-18-6-3-16(4-7-18)33-25(37)34-17-5-8-21(27)20(12-17)26(28,29)30/h3-14,32H,1-2H3,(H2,33,34,37)
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n/an/a 46n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110667
PNG
(US8614234, 135 | US9725433, 135)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C25H21FN4O4/c1-15-3-8-20(26)21(11-15)30-25(32)29-17-4-6-18(7-5-17)34-19-9-10-27-23(13-19)22-12-16(14-28-22)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32)
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n/an/a 47n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110541
PNG
(US8614234, 9 | US9725433, 9)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCC(O)CO)c2)c1
Show InChI InChI=1S/C27H25FN4O5/c1-16-5-6-22(28)23(9-16)32-27(36)17-3-2-4-20(10-17)37-21-7-8-29-25(12-21)24-11-18(13-30-24)26(35)31-14-19(34)15-33/h2-13,19,30,33-34H,14-15H2,1H3,(H,31,35)(H,32,36)
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n/an/a 47n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110630
PNG
(US8614234, 98 | US9725433, 98)
Show SMILES OCCOC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C26H20ClF3N4O5/c27-21-6-3-17(12-20(21)26(28,29)30)34-25(37)33-16-1-4-18(5-2-16)39-19-7-8-31-23(13-19)22-11-15(14-32-22)24(36)38-10-9-35/h1-8,11-14,32,35H,9-10H2,(H2,33,34,37)
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n/an/a 51n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110560
PNG
(US8614234, 28 | US9725433, 28)
Show SMILES Cc1ccoc1C(=O)Nc1cc(Oc2ccnc(c2)-c2cc(c[nH]2)C(O)=O)ccc1F
Show InChI InChI=1S/C22H16FN3O5/c1-12-5-7-30-20(12)21(27)26-17-9-14(2-3-16(17)23)31-15-4-6-24-19(10-15)18-8-13(11-25-18)22(28)29/h2-11,25H,1H3,(H,26,27)(H,28,29)
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n/an/a 52n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110660
PNG
(US8614234, 128 | US9725433, 128)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCO)cc2)c1
Show InChI InChI=1S/C26H24FN5O4/c1-16-2-7-21(27)22(12-16)32-26(35)31-18-3-5-19(6-4-18)36-20-8-9-28-24(14-20)23-13-17(15-30-23)25(34)29-10-11-33/h2-9,12-15,30,33H,10-11H2,1H3,(H,29,34)(H2,31,32,35)
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n/an/a 53n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110651
PNG
(US8614234, 119 | US9725433, 119)
Show SMILES OC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(F)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C24H16F4N4O4/c25-19-6-3-15(10-18(19)24(26,27)28)32-23(35)31-14-1-4-16(5-2-14)36-17-7-8-29-21(11-17)20-9-13(12-30-20)22(33)34/h1-12,30H,(H,33,34)(H2,31,32,35)
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n/an/a 54n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110561
PNG
(US8614234, 29 | US9725433, 29)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(F)c(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C23H18FN3O5/c1-13-6-8-31-21(13)22(28)27-18-10-15(3-4-17(18)24)32-16-5-7-25-20(11-16)19-9-14(12-26-19)23(29)30-2/h3-12,26H,1-2H3,(H,27,28)
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n/an/a 55n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110565
PNG
(US8614234, 33 | US8614234, 35 | US9725433, 33)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C23H19N3O5/c1-14-7-9-30-21(14)22(27)26-16-4-3-5-17(11-16)31-18-6-8-24-20(12-18)19-10-15(13-25-19)23(28)29-2/h3-13,25H,1-2H3,(H,26,27)
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n/an/a 56n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110574
PNG
(US8614234, 42 | US9725433, 42)
Show SMILES COC(=O)c1cc(cs1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C25H20FN3O4S/c1-15-3-8-20(26)22(11-15)29-25(31)28-17-4-6-18(7-5-17)33-19-9-10-27-21(13-19)16-12-23(34-14-16)24(30)32-2/h3-14H,1-2H3,(H2,28,29,31)
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n/an/a 60n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110559
PNG
(US8614234, 27 | US9725433, 27)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2cccc(NC(=O)c3sccc3C)c2)ccn1
Show InChI InChI=1S/C23H19N3O4S/c1-14-7-9-31-21(14)22(27)26-16-4-3-5-17(11-16)30-18-6-8-24-20(12-18)19-10-15(13-25-19)23(28)29-2/h3-13,25H,1-2H3,(H,26,27)
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n/an/a 66n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110612
PNG
(US8614234, 80 | US9725433, 80)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Sc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1
Show InChI InChI=1S/C24H19FN4O3S/c1-14-2-7-19(25)20(10-14)29-24(32)28-16-3-5-17(6-4-16)33-18-8-9-26-22(12-18)21-11-15(13-27-21)23(30)31/h2-13,27H,1H3,(H,30,31)(H2,28,29,32)
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n/an/a 69n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110566
PNG
(US8614234, 34 | US9725433, 34)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2ccc[nH]2)c1
Show InChI InChI=1S/C21H17N3O3/c1-14-8-11-26-20(14)21(25)24-15-4-2-5-16(12-15)27-17-7-10-23-19(13-17)18-6-3-9-22-18/h2-13,22H,1H3,(H,24,25)
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n/an/a 70n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110643
PNG
(US8614234, 111 | US9725433, 111)
Show SMILES COCCOCCOC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C29H29FN4O6/c1-19-3-8-24(30)25(15-19)34-29(36)33-21-4-6-22(7-5-21)40-23-9-10-31-27(17-23)26-16-20(18-32-26)28(35)39-14-13-38-12-11-37-2/h3-10,15-18,32H,11-14H2,1-2H3,(H2,33,34,36)
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n/an/a 71n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110650
PNG
(US8614234, 118 | US9725433, 118)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2F)ccn1
Show InChI InChI=1S/C25H20F2N4O4/c1-14-3-5-18(26)20(9-14)31-25(33)30-16-4-6-23(19(27)11-16)35-17-7-8-28-22(12-17)21-10-15(13-29-21)24(32)34-2/h3-13,29H,1-2H3,(H2,30,31,33)
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n/an/a 85n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110652
PNG
(US8614234, 120 | US9725433, 120)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(F)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C25H18F4N4O4/c1-36-23(34)14-10-21(31-13-14)22-12-18(8-9-30-22)37-17-5-2-15(3-6-17)32-24(35)33-16-4-7-20(26)19(11-16)25(27,28)29/h2-13,31H,1H3,(H2,32,33,35)
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n/an/a 98n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110661
PNG
(US8614234, 129 | US9725433, 129)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)N3CCC(O)CC3)cc2)c1
Show InChI InChI=1S/C29H28FN5O4/c1-18-2-7-24(30)25(14-18)34-29(38)33-20-3-5-22(6-4-20)39-23-8-11-31-27(16-23)26-15-19(17-32-26)28(37)35-12-9-21(36)10-13-35/h2-8,11,14-17,21,32,36H,9-10,12-13H2,1H3,(H2,33,34,38)
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n/an/a 102n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110658
PNG
(US8614234, 126 | US9725433, 126)
Show SMILES COC(=O)CC1CCN(CC1)C(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C32H32FN5O5/c1-20-3-8-26(33)27(15-20)37-32(41)36-23-4-6-24(7-5-23)43-25-9-12-34-29(18-25)28-17-22(19-35-28)31(40)38-13-10-21(11-14-38)16-30(39)42-2/h3-9,12,15,17-19,21,35H,10-11,13-14,16H2,1-2H3,(H2,36,37,41)
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n/an/a 116n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110558
PNG
(US8614234, 26 | US9725433, 26)
Show SMILES Cc1ccsc1C(=O)Nc1cccc(Oc2ccnc(c2)-c2cc(c[nH]2)C(O)=O)c1
Show InChI InChI=1S/C22H17N3O4S/c1-13-6-8-30-20(13)21(26)25-15-3-2-4-16(10-15)29-17-5-7-23-19(11-17)18-9-14(12-24-18)22(27)28/h2-12,24H,1H3,(H,25,26)(H,27,28)
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n/an/a 120n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110654
PNG
(US8614234, 122 | US9725433, 122)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C25H18ClF3N4O4/c1-36-23(34)14-10-21(31-13-14)22-12-18(8-9-30-22)37-17-5-2-15(3-6-17)32-24(35)33-16-4-7-20(26)19(11-16)25(27,28)29/h2-13,31H,1H3,(H2,32,33,35)
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n/an/a 130n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110620
PNG
(US8614234, 88 | US9725433, 88)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Sc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)ccn1
Show InChI InChI=1S/C25H21FN4O3S/c1-15-3-8-20(26)21(11-15)30-25(32)29-17-4-6-18(7-5-17)34-19-9-10-27-23(13-19)22-12-16(14-28-22)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32)
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n/an/a 477n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110538
PNG
(US8614234, 6 | US9725433, 6)
Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Nc2cccc(NC(=O)c3occc3C)c2)ccn1
Show InChI InChI=1S/C23H20N4O4/c1-14-7-9-31-21(14)22(28)27-17-5-3-4-16(11-17)26-18-6-8-24-20(12-18)19-10-15(13-25-19)23(29)30-2/h3-13,25H,1-2H3,(H,24,26)(H,27,28)
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n/an/a 506n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110680
PNG
(US8614234, 148 | US9725433, 148)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccnc(c2)-c2ccc[nH]2)c1
Show InChI InChI=1S/C23H19FN4O/c1-15-4-9-19(24)21(13-15)28-23(29)27-18-7-5-16(6-8-18)17-10-12-26-22(14-17)20-3-2-11-25-20/h2-14,25H,1H3,(H2,27,28,29)
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n/an/a 1.38E+3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110569
PNG
(US8614234, 37 | US9725433, 37)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(Oc2ccnc(c2)-c2ccc[nH]2)cc1
Show InChI InChI=1S/C21H17N3O3/c1-14-9-12-26-20(14)21(25)24-15-4-6-16(7-5-15)27-17-8-11-23-19(13-17)18-3-2-10-22-18/h2-13,22H,1H3,(H,24,25)
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n/an/a 2.61E+3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110673
PNG
(US8614234, 141 | US9725433, 141)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3cc(N)nc(c3)-c3ccc[nH]3)cc2)c1
Show InChI InChI=1S/C23H20FN5O2/c1-14-4-9-18(24)20(11-14)29-23(30)27-15-5-7-16(8-6-15)31-17-12-21(28-22(25)13-17)19-3-2-10-26-19/h2-13,26H,1H3,(H2,25,28)(H2,27,29,30)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110537
PNG
(US8614234, 5 | US9725433, 5)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Nc2ccnc(c2)-c2cc(c[nH]2)C(O)=O)c1
Show InChI InChI=1S/C22H18N4O4/c1-13-6-8-30-20(13)21(27)26-16-4-2-3-15(10-16)25-17-5-7-23-19(11-17)18-9-14(12-24-18)22(28)29/h2-12,24H,1H3,(H,23,25)(H,26,27)(H,28,29)
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n/an/a 2.96E+3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110679
PNG
(US8614234, 147 | US9725433, 147)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccnc(c2)-c2cc[nH]c2)c1
Show InChI InChI=1S/C23H19FN4O/c1-15-2-7-20(24)22(12-15)28-23(29)27-19-5-3-16(4-6-19)17-9-11-26-21(13-17)18-8-10-25-14-18/h2-14,25H,1H3,(H2,27,28,29)
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n/an/a 3.51E+3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110678
PNG
(US8614234, 146 | US9725433, 146)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)-c2ccnc(c2)-c2ccc[nH]2)c1
Show InChI InChI=1S/C23H19FN4O/c1-15-7-8-19(24)21(12-15)28-23(29)27-18-5-2-4-16(13-18)17-9-11-26-22(14-17)20-6-3-10-25-20/h2-14,25H,1H3,(H2,27,28,29)
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n/an/a 7.01E+3n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110677
PNG
(US8614234, 145 | US9725433, 145)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)-c1ccc(nc1)-c1ccc[nH]1
Show InChI InChI=1S/C22H18N4O/c27-22(25-18-5-2-1-3-6-18)26-19-11-8-16(9-12-19)17-10-13-21(24-15-17)20-7-4-14-23-20/h1-15,23H,(H2,25,26,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110672
PNG
(US8614234, 140 | US9725433, 140)
Show SMILES COC(=O)c1cc(cn1C(=O)OC(C)(C)C)-c1cc(Oc2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)cc(N)n1
Show InChI InChI=1S/C30H30FN5O6/c1-17-6-11-22(31)24(12-17)35-28(38)33-19-7-9-20(10-8-19)41-21-14-23(34-26(32)15-21)18-13-25(27(37)40-5)36(16-18)29(39)42-30(2,3)4/h6-16H,1-5H3,(H2,32,34)(H2,33,35,38)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM110568
PNG
(US8614234, 36 | US9725433, 36)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc(Oc2ccnc(c2)-c2ccc[nH]2)cc1
Show InChI InChI=1S/C23H18FN3O2/c1-15-4-9-20(24)19(13-15)23(28)27-16-5-7-17(8-6-16)29-18-10-12-26-22(14-18)21-3-2-11-25-21/h2-14,25H,1H3,(H,27,28)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...

US Patent US9725433 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%