Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330363![]() (2-(3-Fluoro-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330356![]() ((1S)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330355![]() ((1R)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330354![]() (2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330378![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330368![]() ((1R)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330346![]() (2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330371![]() ((1S)-1-methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330374![]() (1-Methyl-6- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,3- t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330361![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330367![]() ((1S)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330351![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330373![]() ((1S)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330357![]() (1-Cyclopropyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330352![]() (1-(2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330379![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330365![]() (6-{[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330360![]() (1-Cyclobutyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330358![]() (1-Cyclopentyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330347![]() (1,1,1-Trifluoro-2-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330342![]() (1-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330376![]() ((1R)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330345![]() (1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330370![]() ((1R)-1-Methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330377![]() ((1S)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330364![]() (5-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 183 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330366![]() ((1R)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330356![]() ((1S)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 241 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330363![]() (2-(3-Fluoro-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330343![]() (1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 271 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330371![]() ((1S)-1-methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 289 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330355![]() ((1R)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 297 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330362![]() (2-(4-Fluoro-3-{[(3R,6R)- 6-methyl-1-{[2-(2H- 1,2,3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 354 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330372![]() ((1R)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM330369![]() ((1S)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 394 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330354![]() (2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 436 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330373![]() ((1S)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 648 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330374![]() (1-Methyl-6- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,3- t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 742 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330361![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 827 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330346![]() (2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 996 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330376![]() ((1R)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330368![]() ((1R)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330352![]() (1-(2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330367![]() ((1S)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330365![]() (6-{[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330357![]() (1-Cyclopropyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330377![]() ((1S)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330358![]() (1-Cyclopentyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330345![]() (1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330342![]() (1-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330372![]() ((1R)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330347![]() (1,1,1-Trifluoro-2-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330366![]() ((1R)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330378![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330360![]() (1-Cyclobutyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330362![]() (2-(4-Fluoro-3-{[(3R,6R)- 6-methyl-1-{[2-(2H- 1,2,3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330364![]() (5-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330370![]() ((1R)-1-Methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330351![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330343![]() (1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330379![]() (2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM330369![]() ((1S)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A... | US Patent US9725434 (2017) BindingDB Entry DOI: 10.7270/Q2TX3HG0 | |||||||||||
More data for this Ligand-Target Pair |