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Patent code US9725445

Compile Data Set for Download or QSAR

Found 668 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330868
PNG
(US9725445, 3-49)
Show SMILES CN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 26n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330872
PNG
(US9725445, 3-53)
Show SMILES CC(C)(C)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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n/an/a 39n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330970
PNG
(US9725445, 3-151)
Show SMILES CC(C)(C)OC(=O)CN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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n/an/a 41n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330919
PNG
(US9725445, 3-100)
Show SMILES CC(C)(C)N1Cc2cc(Nc3nn([C@H]4CCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330879
PNG
(US9725445, 3-60)
Show SMILES CCN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330996
PNG
(US9725445, 3-177)
Show SMILES CC(C)(C)N1Cc2cc(Nc3nn([C@@H]4CCCCC[C@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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n/an/a 46n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330979
PNG
(US9725445, 3-160)
Show SMILES COCC(C)(C)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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n/an/a 49n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330877
PNG
(US9725445, 3-58)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330873
PNG
(US9725445, 3-54)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc4c(CNS4(=O)=O)c3)c12)[C@H]1CCCC[C@@H]1C#N
PDB

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n/an/a 51n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330921
PNG
(US9725445, 3-102)
Show SMILES CN1Cc2cc(Nc3nn([C@H]4CCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331107
PNG
(US9725445, 15-52)
Show SMILES O=C1N(Cc2cc(Nc3nn([C@@H]4CCCCC[C@H]4C#N)c4cc[nH]c(=O)c34)ccc12)C1CCCC1
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330900
PNG
(US9725445, 3-81)
Show SMILES CC(C)(CCO)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331141
PNG
(US9725445, 21-1)
Show SMILES CC1(C)Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
Show InChI InChI=1S/C23H25N5O3S/c1-23(2)12-15-11-16(7-8-19(15)32(23,30)31)26-21-20-18(9-10-25-22(20)29)28(27-21)17-6-4-3-5-14(17)13-24/h7-11,14,17H,3-6,12H2,1-2H3,(H,25,29)(H,26,27)/t14-,17+/m1/s1
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330973
PNG
(US9725445, 3-154)
Show SMILES O=C1N(Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12)C1CCCC1
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330920
PNG
(US9725445, 3-101)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4CCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330972
PNG
(US9725445, 3-153)
Show SMILES CC(C)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2C1=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331099
PNG
(US9725445, 15-44)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc4c(CN(C5CCOCC5)S4(=O)=O)c3)c12)[C@H]1CCCC[C@@H]1C#N
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330978
PNG
(US9725445, 3-159)
Show SMILES COCC(C)(C)CN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331133
PNG
(US9725445, 16-3)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331092
PNG
(US9725445, 15-37 | US9725445, 15-38)
Show SMILES CC(C)C(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1C)n1ccnn1
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331118
PNG
(US9725445, 15-63)
Show SMILES CC1(CCOCC1)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2C1=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330878
PNG
(US9725445, 3-59)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc4c(CCS4(=O)=O)c3)c12)[C@H]1CCCC[C@@H]1C#N
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331069
PNG
(US9725445, 15-14)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc(cc3)-c3cnn(CCC#N)c3)c12)[C@H]1CCCC[C@@H]1C#N
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330902
PNG
(US9725445, 3-83)
Show SMILES COCCN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330882
PNG
(US9725445, 3-63)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc4c(CN(CC5CC5)S4(=O)=O)c3)c12)[C@H]1CCCC[C@@H]1C#N
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331092
PNG
(US9725445, 15-37 | US9725445, 15-38)
Show SMILES CC(C)C(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1C)n1ccnn1
PDB

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Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330969
PNG
(US9725445, 3-150)
Show SMILES CC(C)(C)OC(=O)CCN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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n/an/a 66n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330980
PNG
(US9725445, 3-161)
Show SMILES COCCC(C)(C)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 67n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331119
PNG
(US9725445, 15-64)
Show SMILES CC1(CCOCC1)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331078
PNG
(US9725445, 15-23 | US9725445, 15-24)
Show SMILES CC(C)C(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)n1ccnn1
PDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331143
PNG
(US9725445, 21-3)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc4c(CC5(CCOCC5)S4(=O)=O)c3)c12)[C@H]1CCCC[C@@H]1C#N
PDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331132
PNG
(US9725445, 16-2)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331126
PNG
(US9725445, 15-71 | US9725445, 15-72)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
PDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331075
PNG
(US9725445, 15-20)
Show SMILES CC(C)(C)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2C1=O
PDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330898
PNG
(US9725445, 3-79)
Show SMILES CC(C)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 71n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330917
PNG
(US9725445, 3-98)
Show SMILES OC(c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
PDB

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US Patent
n/an/a 75n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331101
PNG
(US9725445, 15-46)
Show SMILES COCC(C)(C)CN1Cc2cc(Nc3nn([C@@H]4CCCCC[C@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 76n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330945
PNG
(US9725445, 3-126 | US9725445, 3-127)
Show SMILES CC1N(C)S(=O)(=O)c2ccc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)cc12
PDB

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US Patent
n/an/a 77n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331126
PNG
(US9725445, 15-71 | US9725445, 15-72)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
PDB

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US Patent
n/an/a 77n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331114
PNG
(US9725445, 15-59)
Show SMILES O=C1N(Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12)C1CCOCC1
PDB

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US Patent
n/an/a 78n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331078
PNG
(US9725445, 15-23 | US9725445, 15-24)
Show SMILES CC(C)C(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)n1ccnn1
PDB

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US Patent
n/an/a 79n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330899
PNG
(US9725445, 3-80)
Show SMILES OCCN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 79n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330827
PNG
(US9725445, 3-8 | US9725445, 3-9)
Show SMILES OC(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
PDB

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US Patent
n/an/a 81n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331109
PNG
(US9725445, 15-54)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc4c(CN(C5CCOCC5)S4(=O)=O)c3)c12)[C@H]1CCCCC[C@@H]1C#N
PDB

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n/an/a 81n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330916
PNG
(US9725445, 3-97)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4CCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2C1=O
PDB

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US Patent
n/an/a 82n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM331089
PNG
(US9725445, 15-34)
Show SMILES O=C1N(Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12)C1CCCCC1
PDB

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US Patent
n/an/a 82n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330881
PNG
(US9725445, 3-62)
Show SMILES CC(C)CN1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
PDB

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US Patent
n/an/a 83n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM331126
PNG
(US9725445, 15-71 | US9725445, 15-72)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
PDB

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US Patent
n/an/a 85n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM330918
PNG
(US9725445, 3-99)
Show SMILES NS(=O)(=O)c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
PDB

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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM331126
PNG
(US9725445, 15-71 | US9725445, 15-72)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
PDB

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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9725445 (2017)


BindingDB Entry DOI: 10.7270/Q2XP771W
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%