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Patent code US9725446

Compile Data Set for Download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (human))
BDBM331161
PNG
(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3c[nH]c4cnccc34)c2c1
Show InChI InChI=1S/C18H12N6/c1-24-10-12(6-23-24)11-4-14-16(8-22-18(14)21-5-11)15-7-20-17-9-19-3-2-13(15)17/h2-10H,1H3/b16-15+
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Merck Patent GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331157
PNG
(1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-naphthyridin...)
Show SMILES c1[nH]c2ncccc2c1-c1nccc2cnccc12
Show InChI InChI=1S/C15H10N4/c1-2-12-13(9-19-15(12)18-5-1)14-11-4-6-16-8-10(11)3-7-17-14/h1-9H,(H,18,19)
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Merck Patent GmbH

US Patent


Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331159
PNG
(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Show SMILES c1[nH]c2cnccc2c1-c1c[nH]c2ncccc12
Show InChI InChI=1S/C14H8N4/c1-2-10-12(7-18-14(10)16-4-1)11-6-17-13-8-15-5-3-9(11)13/h1-8H/b12-11-
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (human))
BDBM331166
PNG
(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(C)c4cnccc34)c2c1
Show InChI InChI=1S/C19H16N6/c1-24-11-17(14-3-4-20-9-18(14)24)16-8-22-19-15(16)5-12(6-21-19)13-7-23-25(2)10-13/h3-11H,1-2H3,(H,21,22)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM331166
PNG
(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(C)c4cnccc34)c2c1
Show InChI InChI=1S/C19H16N6/c1-24-11-17(14-3-4-20-9-18(14)24)16-8-22-19-15(16)5-12(6-21-19)13-7-23-25(2)10-13/h3-11H,1-2H3,(H,21,22)
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Assay Description
The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331163
PNG
(1-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-nap...)
Show SMILES Cc1[nH]c2ncccc2c1-c1nccc2cnccc12
Show InChI InChI=1S/C16H12N4/c1-10-14(13-3-2-6-19-16(13)20-10)15-12-5-7-17-9-11(12)4-8-18-15/h2-9H,1H3,(H,19,20)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM331161
PNG
(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3c[nH]c4cnccc34)c2c1
Show InChI InChI=1S/C18H12N6/c1-24-10-12(6-23-24)11-4-14-16(8-22-18(14)21-5-11)15-7-20-17-9-19-3-2-13(15)17/h2-10H,1H3/b16-15+
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Assay Description
The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331158
PNG
(5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoquino...)
Show SMILES Cn1cc(-c2cccc3cnccc23)c2cccnc12
Show InChI InChI=1S/C17H13N3/c1-20-11-16(15-6-3-8-19-17(15)20)14-5-2-4-12-10-18-9-7-13(12)14/h2-11H,1H3
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331161
PNG
(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3c[nH]c4cnccc34)c2c1
Show InChI InChI=1S/C18H12N6/c1-24-10-12(6-23-24)11-4-14-16(8-22-18(14)21-5-11)15-7-20-17-9-19-3-2-13(15)17/h2-10H,1H3/b16-15+
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331156
PNG
(5-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoquino...)
Show SMILES Cc1[nH]c2ncccc2c1-c1cccc2cnccc12
Show InChI InChI=1S/C17H13N3/c1-11-16(15-6-3-8-19-17(15)20-11)14-5-2-4-12-10-18-9-7-13(12)14/h2-10H,1H3,(H,19,20)
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US Patent


Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331155
PNG
(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(c4cnccc34)S(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H18N6O2S/c1-29-14-17(11-28-29)16-9-20-21(12-27-24(20)26-10-16)22-15-30(23-13-25-8-7-19(22)23)33(31,32)18-5-3-2-4-6-18/h2-15H,1H3,(H,26,27)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (human))
BDBM331155
PNG
(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(c4cnccc34)S(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H18N6O2S/c1-29-14-17(11-28-29)16-9-20-21(12-27-24(20)26-10-16)22-15-30(23-13-25-8-7-19(22)23)33(31,32)18-5-3-2-4-6-18/h2-15H,1H3,(H,26,27)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331153
PNG
(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinoline | US...)
Show SMILES c1[nH]c2ncccc2c1-c1cccc2cnccc12
Show InChI InChI=1S/C16H11N3/c1-3-11-9-17-8-6-12(11)13(4-1)15-10-19-16-14(15)5-2-7-18-16/h1-10H,(H,18,19)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331161
PNG
(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3c[nH]c4cnccc34)c2c1
Show InChI InChI=1S/C18H12N6/c1-24-10-12(6-23-24)11-4-14-16(8-22-18(14)21-5-11)15-7-20-17-9-19-3-2-13(15)17/h2-10H,1H3/b16-15+
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331164
PNG
(5-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-nap...)
Show SMILES Cc1[nH]c2ncccc2c1-c1nccc2c(N)nccc12
Show InChI InChI=1S/C16H13N5/c1-9-13(12-3-2-6-20-16(12)21-9)14-10-4-8-19-15(17)11(10)5-7-18-14/h2-8H,1H3,(H2,17,19)(H,20,21)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331165
PNG
(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-naphthyridin...)
Show SMILES Nc1nccc2c(nccc12)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C15H11N5/c16-14-10-4-6-17-13(9(10)3-7-18-14)12-8-20-15-11(12)2-1-5-19-15/h1-8H,(H2,16,18)(H,19,20)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331162
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin...)
Show SMILES Nc1ncc(-c2c[nH]c3ncccc23)c2ccncc12
Show InChI InChI=1S/C15H11N5/c16-14-13-6-17-5-3-9(13)11(7-19-14)12-8-20-15-10(12)2-1-4-18-15/h1-8H,(H2,16,19)(H,18,20)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331166
PNG
(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(C)c4cnccc34)c2c1
Show InChI InChI=1S/C19H16N6/c1-24-11-17(14-3-4-20-9-18(14)24)16-8-22-19-15(16)5-12(6-21-19)13-7-23-25(2)10-13/h3-11H,1-2H3,(H,21,22)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331166
PNG
(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(C)c4cnccc34)c2c1
Show InChI InChI=1S/C19H16N6/c1-24-11-17(14-3-4-20-9-18(14)24)16-8-22-19-15(16)5-12(6-21-19)13-7-23-25(2)10-13/h3-11H,1-2H3,(H,21,22)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331153
PNG
(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinoline | US...)
Show SMILES c1[nH]c2ncccc2c1-c1cccc2cnccc12
Show InChI InChI=1S/C16H11N3/c1-3-11-9-17-8-6-12(11)13(4-1)15-10-19-16-14(15)5-2-7-18-16/h1-10H,(H,18,19)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (human))
BDBM331159
PNG
(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Show SMILES c1[nH]c2cnccc2c1-c1c[nH]c2ncccc12
Show InChI InChI=1S/C14H8N4/c1-2-10-12(7-18-14(10)16-4-1)11-6-17-13-8-15-5-3-9(11)13/h1-8H/b12-11-
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM331155
PNG
(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(c4cnccc34)S(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H18N6O2S/c1-29-14-17(11-28-29)16-9-20-21(12-27-24(20)26-10-16)22-15-30(23-13-25-8-7-19(22)23)33(31,32)18-5-3-2-4-6-18/h2-15H,1H3,(H,26,27)
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Assay Description
The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM331159
PNG
(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Show SMILES c1[nH]c2cnccc2c1-c1c[nH]c2ncccc12
Show InChI InChI=1S/C14H8N4/c1-2-10-12(7-18-14(10)16-4-1)11-6-17-13-8-15-5-3-9(11)13/h1-8H/b12-11-
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Assay Description
The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331154
PNG
(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinolin-1-yla...)
Show SMILES Nc1nccc2c(cccc12)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H12N4/c17-15-12-4-1-3-10(11(12)6-8-18-15)14-9-20-16-13(14)5-2-7-19-16/h1-9H,(H2,17,18)(H,19,20)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331152
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)cinnoline | US972...)
Show SMILES c1[nH]c2ncccc2c1-c1cnnc2ccccc12
Show InChI InChI=1S/C15H10N4/c1-2-6-14-10(4-1)13(9-18-19-14)12-8-17-15-11(12)5-3-7-16-15/h1-9H,(H,16,17)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331162
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin...)
Show SMILES Nc1ncc(-c2c[nH]c3ncccc23)c2ccncc12
Show InChI InChI=1S/C15H11N5/c16-14-13-6-17-5-3-9(13)11(7-19-14)12-8-20-15-10(12)2-1-4-18-15/h1-8H,(H2,16,19)(H,18,20)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331160
PNG
(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Show SMILES Cn1cc(-c2c[nH]c3ncccc23)c2ccncc12
Show InChI InChI=1S/C15H12N4/c1-19-9-13(10-4-6-16-8-14(10)19)12-7-18-15-11(12)3-2-5-17-15/h2-9H,1H3,(H,17,18)
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (human))
BDBM331160
PNG
(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Show SMILES Cn1cc(-c2c[nH]c3ncccc23)c2ccncc12
Show InChI InChI=1S/C15H12N4/c1-19-9-13(10-4-6-16-8-14(10)19)12-7-18-15-11(12)3-2-5-17-15/h2-9H,1H3,(H,17,18)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM331160
PNG
(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Show SMILES Cn1cc(-c2c[nH]c3ncccc23)c2ccncc12
Show InChI InChI=1S/C15H12N4/c1-19-9-13(10-4-6-16-8-14(10)19)12-7-18-15-11(12)3-2-5-17-15/h2-9H,1H3,(H,17,18)
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Assay Description
The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM331159
PNG
(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Show SMILES c1[nH]c2cnccc2c1-c1c[nH]c2ncccc12
Show InChI InChI=1S/C14H8N4/c1-2-10-12(7-18-14(10)16-4-1)11-6-17-13-8-15-5-3-9(11)13/h1-8H/b12-11-
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Assay Description
In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM331160
PNG
(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Show SMILES Cn1cc(-c2c[nH]c3ncccc23)c2ccncc12
Show InChI InChI=1S/C15H12N4/c1-19-9-13(10-4-6-16-8-14(10)19)12-7-18-15-11(12)3-2-5-17-15/h2-9H,1H3,(H,17,18)
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Assay Description
The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (human))
BDBM331153
PNG
(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinoline | US...)
Show SMILES c1[nH]c2ncccc2c1-c1cccc2cnccc12
Show InChI InChI=1S/C16H11N3/c1-3-11-9-17-8-6-12(11)13(4-1)15-10-19-16-14(15)5-2-7-18-16/h1-10H,(H,18,19)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...


US Patent US9725446 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%