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Patent code US9725465

Compile Data Set for Download or QSAR

Found 406 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331646
PNG
(Preparation of 5-(4-(2-((5-(tert-butyl)isoxazol-3-...)
Show SMILES CC(C)(C)c1cc(NC(=O)Cc2ccc(cc2)-c2cnc3[nH]c(cc3c2)C(=O)NCCO)no1
Show InChI InChI=1S/C25H27N5O4/c1-25(2,3)20-13-21(30-34-20)29-22(32)10-15-4-6-16(7-5-15)18-11-17-12-19(24(33)26-8-9-31)28-23(17)27-14-18/h4-7,11-14,31H,8-10H2,1-3H3,(H,26,33)(H,27,28)(H,29,30,32)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331648
PNG
(Preparation of 5-(4-(2-((5-(tert-butyl)isoxazol-3-...)
Show SMILES CN(C)CCNC(=O)c1cc2cc(cnc2[nH]1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C27H32N6O3/c1-27(2,3)22-15-23(32-36-22)31-24(34)12-17-6-8-18(9-7-17)20-13-19-14-21(30-25(19)29-16-20)26(35)28-10-11-33(4)5/h6-9,13-16H,10-12H2,1-5H3,(H,28,35)(H,29,30)(H,31,32,34)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331651
PNG
(Preparation of 5-(4-(2-((5-(tert-butyl)isoxazol-3-...)
Show SMILES CN1CCC(CC1)NC(=O)c1cc2cc(cnc2[nH]1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C29H34N6O3/c1-29(2,3)24-16-25(34-38-24)33-26(36)13-18-5-7-19(8-6-18)21-14-20-15-23(32-27(20)30-17-21)28(37)31-22-9-11-35(4)12-10-22/h5-8,14-17,22H,9-13H2,1-4H3,(H,30,32)(H,31,37)(H,33,34,36)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331652
PNG
(Preparation of 2-(2-fluoro-4-(2-(hydroxymethyl)-1H...)
Show SMILES OCc1cc2cc(cnc2[nH]1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C23H18F4N4O3/c24-17-7-12(15-5-14-6-16(11-32)29-21(14)28-10-15)1-2-13(17)8-20(33)30-19-9-18(34-31-19)22(3-4-22)23(25,26)27/h1-2,5-7,9-10,32H,3-4,8,11H2,(H,28,29)(H,30,31,33)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331658
PNG
(Preparation of 2-(2-fluoro-4-(7-methoxy-6-(2-morph...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCOCC1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C30H29F4N5O5/c1-41-24-15-22-21(14-25(24)43-11-8-39-6-9-42-10-7-39)35-17-23(36-22)19-3-2-18(20(31)12-19)13-28(40)37-27-16-26(44-38-27)29(4-5-29)30(32,33)34/h2-3,12,14-17H,4-11,13H2,1H3,(H,37,38,40)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331659
PNG
(Preparation of 2-(2-fluoro-4-(7-(2-hydroxyethoxy)-...)
Show SMILES COc1cc2ncc(nc2cc1OCCO)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C26H22F4N4O5/c1-37-20-10-17-18(11-21(20)38-7-6-35)32-19(13-31-17)15-3-2-14(16(27)8-15)9-24(36)33-23-12-22(39-34-23)25(4-5-25)26(28,29)30/h2-3,8,10-13,35H,4-7,9H2,1H3,(H,33,34,36)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331660
PNG
(Preparation of 2-(2-fluoro-4-(7-methoxy-6-(2-(4-me...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCN(C)CC1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H32F4N6O4/c1-40-7-9-41(10-8-40)11-12-44-26-15-22-23(16-25(26)43-2)37-24(18-36-22)20-4-3-19(21(32)13-20)14-29(42)38-28-17-27(45-39-28)30(5-6-30)31(33,34)35/h3-4,13,15-18H,5-12,14H2,1-2H3,(H,38,39,42)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331660
PNG
(Preparation of 2-(2-fluoro-4-(7-methoxy-6-(2-(4-me...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCN(C)CC1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H32F4N6O4/c1-40-7-9-41(10-8-40)11-12-44-26-15-22-23(16-25(26)43-2)37-24(18-36-22)20-4-3-19(21(32)13-20)14-29(42)38-28-17-27(45-39-28)30(5-6-30)31(33,34)35/h3-4,13,15-18H,5-12,14H2,1-2H3,(H,38,39,42)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331661
PNG
(Preparation of 2-(4-(6-(2-(3,3-difluoropyrrolidin-...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCC(F)(F)C1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C30H27F6N5O4/c1-43-23-13-21-20(12-24(23)44-9-8-41-7-6-29(32,33)16-41)37-15-22(38-21)18-3-2-17(19(31)10-18)11-27(42)39-26-14-25(45-40-26)28(4-5-28)30(34,35)36/h2-3,10,12-15H,4-9,11,16H2,1H3,(H,39,40,42)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331666
PNG
(Preparation of 2-(2-Fluoro-4-{6-[2-(3-fluoro-4-hyd...)
Show SMILES COc1cc2ncc(cc2cc1OCCN1CC[C@H](O)[C@@H](F)C1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C32H33F5N4O5/c1-31(2,32(35,36)37)28-15-29(40-46-28)39-30(43)13-19-5-4-18(11-22(19)33)21-10-20-12-27(26(44-3)14-24(20)38-16-21)45-9-8-41-7-6-25(42)23(34)17-41/h4-5,10-12,14-16,23,25,42H,6-9,13,17H2,1-3H3,(H,39,40,43)/t23-,25-/m0/s1
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331674
PNG
(Preparation of 2-(2-fluoro-4-(7-methoxy-6-(2-morph...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCOCC1)-c1ccc(CC(=O)Nc2cc(no2)C2(C)CC2)c(F)c1
Show InChI InChI=1S/C30H32FN5O5/c1-30(5-6-30)27-17-29(41-35-27)34-28(37)14-19-3-4-20(13-21(19)31)24-18-32-22-15-26(25(38-2)16-23(22)33-24)40-12-9-36-7-10-39-11-8-36/h3-4,13,15-18H,5-12,14H2,1-2H3,(H,34,37)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331674
PNG
(Preparation of 2-(2-fluoro-4-(7-methoxy-6-(2-morph...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCOCC1)-c1ccc(CC(=O)Nc2cc(no2)C2(C)CC2)c(F)c1
Show InChI InChI=1S/C30H32FN5O5/c1-30(5-6-30)27-17-29(41-35-27)34-28(37)14-19-3-4-20(13-21(19)31)24-18-32-22-15-26(25(38-2)16-23(22)33-24)40-12-9-36-7-10-39-11-8-36/h3-4,13,15-18H,5-12,14H2,1-2H3,(H,34,37)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331675
PNG
(Preparation of 2-(4-(6-(2-(3,3-dimethylmorpholino)...)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCOCC1(C)C)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C32H33F4N5O5/c1-30(2)18-44-10-8-41(30)9-11-45-26-14-22-23(15-25(26)43-3)38-24(17-37-22)20-5-4-19(21(33)12-20)13-29(42)39-28-16-27(46-40-28)31(6-7-31)32(34,35)36/h4-5,12,14-17H,6-11,13,18H2,1-3H3,(H,39,40,42)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331689
PNG
(US9725465, Example 110)
Show SMILES CN(C)C1CCN(C1)C(=O)c1cc2cc(cnc2[nH]1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C29H28F4N6O3/c1-38(2)20-5-8-39(15-20)27(41)22-11-18-9-19(14-34-26(18)35-22)16-3-4-17(21(30)10-16)12-25(40)36-24-13-23(42-37-24)28(6-7-28)29(31,32)33/h3-4,9-11,13-14,20H,5-8,12,15H2,1-2H3,(H,34,35)(H,36,37,40)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331692
PNG
(US9725465, Example 113)
Show SMILES CN1CC(C1)NC(=O)c1cc2cc(cnc2[nH]1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H24F4N6O3/c1-37-12-18(13-37)33-25(39)20-8-16-6-17(11-32-24(16)34-20)14-2-3-15(19(28)7-14)9-23(38)35-22-10-21(40-36-22)26(4-5-26)27(29,30)31/h2-3,6-8,10-11,18H,4-5,9,12-13H2,1H3,(H,32,34)(H,33,39)(H,35,36,38)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331692
PNG
(US9725465, Example 113)
Show SMILES CN1CC(C1)NC(=O)c1cc2cc(cnc2[nH]1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H24F4N6O3/c1-37-12-18(13-37)33-25(39)20-8-16-6-17(11-32-24(16)34-20)14-2-3-15(19(28)7-14)9-23(38)35-22-10-21(40-36-22)26(4-5-26)27(29,30)31/h2-3,6-8,10-11,18H,4-5,9,12-13H2,1H3,(H,32,34)(H,33,39)(H,35,36,38)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331694
PNG
(US9725465, Example 115)
Show SMILES COc1cc2ncc(cc2c(OC)c1OC)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H25F4N3O5/c1-26(2,27(29,30)31)21-12-22(34-39-21)33-23(35)10-15-7-6-14(9-18(15)28)16-8-17-19(32-13-16)11-20(36-3)25(38-5)24(17)37-4/h6-9,11-13H,10H2,1-5H3,(H,33,34,35)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331695
PNG
(US9725465, Example 116)
Show SMILES COc1cc2ncc(cc2c(OC)c1OC)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,3)22-14-23(30-35-22)29-24(31)11-16-7-9-17(10-8-16)18-12-19-20(28-15-18)13-21(32-4)26(34-6)25(19)33-5/h7-10,12-15H,11H2,1-6H3,(H,29,30,31)
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n/an/an/a<5n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331697
PNG
(US9725465, Example 118)
Show SMILES CCOc1cc2ncc(nc2cc1OCC)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H24F4N4O4/c1-3-37-21-11-18-19(12-22(21)38-4-2)33-20(14-32-18)16-6-5-15(17(28)9-16)10-25(36)34-24-13-23(39-35-24)26(7-8-26)27(29,30)31/h5-6,9,11-14H,3-4,7-8,10H2,1-2H3,(H,34,35,36)
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n/an/an/a<5n/an/an/an/an/a



Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331709
PNG
(US9725465, Example 130)
Show SMILES COc1cc2nc(cnc2cc1OCCOC(C)=O)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C28H24F4N4O6/c1-15(37)40-7-8-41-23-11-19-20(12-22(23)39-2)34-21(14-33-19)17-4-3-16(18(29)9-17)10-26(38)35-25-13-24(42-36-25)27(5-6-27)28(30,31)32/h3-4,9,11-14H,5-8,10H2,1-2H3,(H,35,36,38)
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Ambit Biosciences Corporation

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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331712
PNG
(US9725465, Example 133)
Show SMILES COc1cc2nc(C(O)=O)c(nc2cc1OC)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C26H20F4N4O6/c1-38-17-9-15-16(10-18(17)39-2)32-23(24(36)37)22(31-15)13-4-3-12(14(27)7-13)8-21(35)33-20-11-19(40-34-20)25(5-6-25)26(28,29)30/h3-4,7,9-11H,5-6,8H2,1-2H3,(H,36,37)(H,33,34,35)
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Ambit Biosciences Corporation

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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331713
PNG
(US9725465, Example 134)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCCC1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C30H29F4N5O4/c1-41-24-15-22-21(14-25(24)42-11-10-39-8-2-3-9-39)35-17-23(36-22)19-5-4-18(20(31)12-19)13-28(40)37-27-16-26(43-38-27)29(6-7-29)30(32,33)34/h4-5,12,14-17H,2-3,6-11,13H2,1H3,(H,37,38,40)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331723
PNG
(US9725465, Example 144)
Show SMILES COc1cc2nc(cnc2cc1OC1COC1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H22F4N4O5/c1-37-21-9-19-18(8-22(21)39-16-12-38-13-16)32-11-20(33-19)15-3-2-14(17(28)6-15)7-25(36)34-24-10-23(40-35-24)26(4-5-26)27(29,30)31/h2-3,6,8-11,16H,4-5,7,12-13H2,1H3,(H,34,35,36)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331728
PNG
(US9725465, Example 149)
Show SMILES CCN1CC(C1)Oc1cc2ncc(nc2cc1OC)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C29H29F4N5O4/c1-5-38-14-18(15-38)41-24-10-20-21(11-23(24)40-4)35-22(13-34-20)17-7-6-16(19(30)8-17)9-27(39)36-26-12-25(42-37-26)28(2,3)29(31,32)33/h6-8,10-13,18H,5,9,14-15H2,1-4H3,(H,36,37,39)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331737
PNG
(US9725465, Example 158)
Show SMILES COc1cc2ncc(nc2cc1OCCN(C)C)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C28H27F4N5O4/c1-37(2)8-9-40-23-13-20-19(12-22(23)39-3)33-15-21(34-20)17-5-4-16(18(29)10-17)11-26(38)35-25-14-24(41-36-25)27(6-7-27)28(30,31)32/h4-5,10,12-15H,6-9,11H2,1-3H3,(H,35,36,38)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331738
PNG
(US9725465, Example 159)
Show SMILES COCCOc1cc2ncc(nc2cc1OC)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H26F4N4O5/c1-26(2,27(29,30)31)23-13-24(35-40-23)34-25(36)10-15-5-6-16(9-17(15)28)20-14-32-18-11-22(39-8-7-37-3)21(38-4)12-19(18)33-20/h5-6,9,11-14H,7-8,10H2,1-4H3,(H,34,35,36)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331742
PNG
(US9725465, Example 163)
Show SMILES COc1cc2nc(cnc2cc1OCc1ccccc1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H24F4N4O4/c1-41-25-14-23-22(13-26(25)42-17-18-5-3-2-4-6-18)36-16-24(37-23)20-8-7-19(21(32)11-20)12-29(40)38-28-15-27(43-39-28)30(9-10-30)31(33,34)35/h2-8,11,13-16H,9-10,12,17H2,1H3,(H,38,39,40)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331743
PNG
(US9725465, Example 164)
Show SMILES COc1cc2nc(cnc2cc1O)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C24H20F4N4O4/c1-23(2,24(26,27)28)20-10-21(32-36-20)31-22(34)7-12-4-5-13(6-14(12)25)17-11-29-15-8-18(33)19(35-3)9-16(15)30-17/h4-6,8-11,33H,7H2,1-3H3,(H,31,32,34)
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Ambit Biosciences Corporation

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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331751
PNG
(US9725465, Example 172)
Show SMILES COc1cc2ncc(nc2cc1OC)-c1ccc(CC(=O)Nc2cc(nn2C)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C26H23F4N5O3/c1-35-23(12-22(34-35)25(6-7-25)26(28,29)30)33-24(36)9-14-4-5-15(8-16(14)27)19-13-31-17-10-20(37-2)21(38-3)11-18(17)32-19/h4-5,8,10-13H,6-7,9H2,1-3H3,(H,33,36)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331753
PNG
(US9725465, Example 174)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CC(C)OC(C)C1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C32H33F4N5O5/c1-18-16-41(17-19(2)45-18)8-9-44-27-12-23-24(13-26(27)43-3)38-25(15-37-23)21-5-4-20(22(33)10-21)11-30(42)39-29-14-28(46-40-29)31(6-7-31)32(34,35)36/h4-5,10,12-15,18-19H,6-9,11,16-17H2,1-3H3,(H,39,40,42)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331759
PNG
(US9725465, Example 180)
Show SMILES COc1cc2ncc(nc2cc1OC)-c1ccc(CC(=O)Nc2cc(n[nH]2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C25H21F4N5O3/c1-36-19-9-16-17(10-20(19)37-2)31-18(12-30-16)14-4-3-13(15(26)7-14)8-23(35)32-22-11-21(33-34-22)24(5-6-24)25(27,28)29/h3-4,7,9-12H,5-6,8H2,1-2H3,(H2,32,33,34,35)
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Ambit Biosciences Corporation

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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331765
PNG
(US9725465, Example 186)
Show SMILES COc1cc2nc(cnc2cc1OCC(=O)N(C)C)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C28H25F4N5O5/c1-37(2)26(39)14-41-22-10-18-19(11-21(22)40-3)34-20(13-33-18)16-5-4-15(17(29)8-16)9-25(38)35-24-12-23(42-36-24)27(6-7-27)28(30,31)32/h4-5,8,10-13H,6-7,9,14H2,1-3H3,(H,35,36,38)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331768
PNG
(US9725465, Example 189)
Show SMILES COc1cc2ncc(cc2cc1OCCN1CCOCC1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H32F4N4O5/c1-30(2,31(33,34)35)27-17-28(38-44-27)37-29(40)15-20-5-4-19(13-23(20)32)22-12-21-14-26(25(41-3)16-24(21)36-18-22)43-11-8-39-6-9-42-10-7-39/h4-5,12-14,16-18H,6-11,15H2,1-3H3,(H,37,38,40)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331780
PNG
(US9725465, Example 201)
Show SMILES COc1cc2cc(cnc2cc1OCCNCCO)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C29H30F4N4O5/c1-28(2,29(31,32)33)25-15-26(37-42-25)36-27(39)13-18-5-4-17(11-21(18)30)20-10-19-12-23(40-3)24(14-22(19)35-16-20)41-9-7-34-6-8-38/h4-5,10-12,14-16,34,38H,6-9,13H2,1-3H3,(H,36,37,39)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331781
PNG
(US9725465, Example 202)
Show SMILES COc1cc2ncc(nc2cc1OC[C@@H](C)O)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H24F4N4O5/c1-14(36)13-39-22-10-19-18(9-21(22)38-2)32-12-20(33-19)16-4-3-15(17(28)7-16)8-25(37)34-24-11-23(40-35-24)26(5-6-26)27(29,30)31/h3-4,7,9-12,14,36H,5-6,8,13H2,1-2H3,(H,34,35,37)/t14-/m1/s1
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331782
PNG
(US9725465, Example 203)
Show SMILES COc1cc2ncc(nc2cc1OCCCN1CCOCC1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H33F4N5O5/c1-30(2,31(33,34)35)27-17-28(39-45-27)38-29(41)14-19-5-6-20(13-21(19)32)24-18-36-22-15-25(42-3)26(16-23(22)37-24)44-10-4-7-40-8-11-43-12-9-40/h5-6,13,15-18H,4,7-12,14H2,1-3H3,(H,38,39,41)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331789
PNG
(US9725465, Example 210)
Show SMILES COc1cc2nc(cnc2cc1OCCn1cncn1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C28H25F4N7O4/c1-27(2,28(30,31)32)24-12-25(38-43-24)37-26(40)9-16-4-5-17(8-18(16)29)21-13-34-19-10-23(22(41-3)11-20(19)36-21)42-7-6-39-15-33-14-35-39/h4-5,8,10-15H,6-7,9H2,1-3H3,(H,37,38,40)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331798
PNG
(US9725465, Example 219)
Show SMILES COc1cc2ncc(nc2cc1OC)-c1cc(F)c(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)cc1F
Show InChI InChI=1S/C25H21F5N4O4/c1-24(2,25(28,29)30)21-10-22(34-38-21)33-23(35)6-12-5-15(27)13(7-14(12)26)18-11-31-16-8-19(36-3)20(37-4)9-17(16)32-18/h5,7-11H,6H2,1-4H3,(H,33,34,35)
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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331802
PNG
(US9725465, Example 223)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CC2CC(C1)O2)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H29F4N5O5/c1-42-25-12-23-22(11-26(25)43-7-6-40-15-19-10-20(16-40)44-19)36-14-24(37-23)18-3-2-17(21(32)8-18)9-29(41)38-28-13-27(45-39-28)30(4-5-30)31(33,34)35/h2-3,8,11-14,19-20H,4-7,9-10,15-16H2,1H3,(H,38,39,41)
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US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331803
PNG
(US9725465, Example 224)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CC2CC1CO2)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H29F4N5O5/c1-42-25-12-23-22(11-26(25)43-7-6-40-15-20-10-19(40)16-44-20)36-14-24(37-23)18-3-2-17(21(32)8-18)9-29(41)38-28-13-27(45-39-28)30(4-5-30)31(33,34)35/h2-3,8,11-14,19-20H,4-7,9-10,15-16H2,1H3,(H,38,39,41)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331808
PNG
(US9725465, Example 229)
Show SMILES COc1cc2ncc(nc2cc1OC)-c1cnc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C24H21F4N5O4/c1-23(2,24(26,27)28)20-9-21(33-37-20)32-22(34)8-14-13(25)5-12(10-29-14)17-11-30-15-6-18(35-3)19(36-4)7-16(15)31-17/h5-7,9-11H,8H2,1-4H3,(H,32,33,34)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331819
PNG
(US9725465, Example 240)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCCOCC1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H31F4N5O5/c1-42-25-16-23-22(15-26(25)44-12-9-40-7-2-10-43-11-8-40)36-18-24(37-23)20-4-3-19(21(32)13-20)14-29(41)38-28-17-27(45-39-28)30(5-6-30)31(33,34)35/h3-4,13,15-18H,2,5-12,14H2,1H3,(H,38,39,41)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331822
PNG
(US9725465, Example 243)
Show SMILES COc1cc2nc(cnc2cc1OCCN1CCOC[C@@H]1C)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C31H31F4N5O5/c1-18-17-43-9-7-40(18)8-10-44-26-13-22-23(14-25(26)42-2)37-24(16-36-22)20-4-3-19(21(32)11-20)12-29(41)38-28-15-27(45-39-28)30(5-6-30)31(33,34)35/h3-4,11,13-16,18H,5-10,12,17H2,1-2H3,(H,38,39,41)/t18-/m0/s1
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331824
PNG
(US9725465, Example 245)
Show SMILES COc1cc2nc(cnc2cc1OCCN1C2CCC1COC2)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C32H31F4N5O5/c1-43-26-13-24-23(12-27(26)45-9-8-41-20-4-5-21(41)17-44-16-20)37-15-25(38-24)19-3-2-18(22(33)10-19)11-30(42)39-29-14-28(46-40-29)31(6-7-31)32(34,35)36/h2-3,10,12-15,20-21H,4-9,11,16-17H2,1H3,(H,39,40,42)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331825
PNG
(US9725465, Example 246)
Show SMILES COc1cc2nc(cnc2cc1OCC(C)(C)O)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C28H28F4N4O5/c1-26(2,38)14-40-22-10-18-19(11-21(22)39-5)34-20(13-33-18)16-7-6-15(17(29)8-16)9-25(37)35-24-12-23(41-36-24)27(3,4)28(30,31)32/h6-8,10-13,38H,9,14H2,1-5H3,(H,35,36,37)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331634
PNG
(Preparation of 2-(4-(6,7-dimethoxyquinoxalin-2-yl)...)
Show SMILES COc1cc2ncc(nc2cc1OC)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N4O4/c1-24(2,25(26,27)28)21-12-22(32-36-21)31-23(33)9-14-5-7-15(8-6-14)18-13-29-16-10-19(34-3)20(35-4)11-17(16)30-18/h5-8,10-13H,9H2,1-4H3,(H,31,32,33)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331639
PNG
(Preparation of 2-(4-(5,7-dimethoxyquinolin-3-yl)ph...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H22F3N3O4/c1-34-18-11-20-19(21(12-18)35-2)10-17(14-30-20)16-5-3-15(4-6-16)9-24(33)31-23-13-22(36-32-23)25(7-8-25)26(27,28)29/h3-6,10-14H,7-9H2,1-2H3,(H,31,32,33)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331642
PNG
(Preparation of 2-(4-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES FC(F)(F)C1(CC1)c1cc(NC(=O)Cc2ccc(cc2)-c2cnc3[nH]ccc3c2)no1
Show InChI InChI=1S/C22H17F3N4O2/c23-22(24,25)21(6-7-21)17-11-18(29-31-17)28-19(30)9-13-1-3-14(4-2-13)16-10-15-5-8-26-20(15)27-12-16/h1-5,8,10-12H,6-7,9H2,(H,26,27)(H,28,29,30)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM331654
PNG
(Preparation of 2-(4-(6,7-bis(2-hydroxyethoxy)quino...)
Show SMILES OCCOc1cc2ncc(nc2cc1OCCO)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H24F4N4O6/c28-17-9-16(20-14-32-18-11-21(39-7-5-36)22(40-8-6-37)12-19(18)33-20)2-1-15(17)10-25(38)34-24-13-23(41-35-24)26(3-4-26)27(29,30)31/h1-2,9,11-14,36-37H,3-8,10H2,(H,34,35,38)
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US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM331654
PNG
(Preparation of 2-(4-(6,7-bis(2-hydroxyethoxy)quino...)
Show SMILES OCCOc1cc2ncc(nc2cc1OCCO)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H24F4N4O6/c28-17-9-16(20-14-32-18-11-21(39-7-5-36)22(40-8-6-37)12-19(18)33-20)2-1-15(17)10-25(38)34-24-13-23(41-35-24)26(3-4-26)27(29,30)31/h1-2,9,11-14,36-37H,3-8,10H2,(H,34,35,38)
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Ambit Biosciences Corporation

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9725465 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%