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Patent code US9730931

Compile Data Set for Download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB

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UniChem
US Patent
n/an/a<0.200n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249429
PNG
(US9434697, 149 | US9730931, Compound 149)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249436
PNG
(US9434697, 157 | US9730931, Compound 157)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249438
PNG
(US9434697, 159 | US9730931, Compound 159)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
PDB

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PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249439
PNG
(US9434697, 160 | US9730931, Compound 160)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
PDB

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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB

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PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249406
PNG
(US9434697, 123 | US9730931, Compound 123)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249418
PNG
(US9434697, 136 | US9730931, Compound 136)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cc(C)no2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H25Cl2N7O5/c1-5-23(37)33-18-9-7-6-8-17(18)32-21-12-22(31-14-30-21)36(13-16-10-15(2)35-41-16)27(38)34-26-24(28)19(39-3)11-20(40-4)25(26)29/h5-12,14H,1,13H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249426
PNG
(US9434697, 145 | US9730931, Compound 145)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249398
PNG
(US9434697, 111 | US9730931, Compound 111)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249428
PNG
(US9434697, 148 | US9730931, Compound 148)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249447
PNG
(US9434697, 168 | US9730931, Compound 168)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249401
PNG
(US9434697, 114 | US9730931, Compound 114)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
PDB

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UniChem
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249423
PNG
(US9434697, 142 | US9730931, Compound 142)
Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
PDB

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PC sid
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US Patent
n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249425
PNG
(US9434697, 144 | US9730931, Compound 144)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249430
PNG
(US9434697, 150 | US9730931, Compound 150)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249441
PNG
(US9434697, 162 | US9730931, Compound 162)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249444
PNG
(US9434697, 165 | US9730931, Compound 165)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
PDB

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UniProtKB/SwissProt

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UniChem
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249446
PNG
(US9434697, 167 | US9730931, Compound 167)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100 | US9730931, Compound 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249395
PNG
(US9434697, 107 | US9730931, Compound 107)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249400
PNG
(US9434697, 113 | US9730931, Compound 113)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249408
PNG
(US9434697, 125 | US9730931, Compound 125)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249414
PNG
(US9434697, 131 | US9730931, Compound 131)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249417
PNG
(US9434697, 135 | US9730931, Compound 135)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249440
PNG
(US9434697, 161 | US9730931, Compound 161)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100 | US9730931, Compound 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249407
PNG
(US9434697, 124 | US9730931, Compound 124)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249419
PNG
(US9434697, 137 | US9730931, Compound 137)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cc(CCN(C)C)ccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-17-9-8-16(10-11-35(2)3)12-18(17)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249421
PNG
(US9434697, 140 | US9730931, Compound 140)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)cccc2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-4-25(38)33-22-15-18(37-13-11-36(5-2)12-14-37)9-10-21(22)32-23-16-24(31-17-30-23)35(3)27(39)34-26-19(28)7-6-8-20(26)29/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,38)(H,34,39)(H,30,31,32)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249427
PNG
(US9434697, 147 | US9730931, Compound 147)
Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249434
PNG
(US9434697, 155 | US9730931, Compound 155)
Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249452
PNG
(US9434697, 181 | US9730931, Compound 181)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1
Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
PDB
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n/an/a 1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249409
PNG
(US9434697, 126 | US9730931, Compound 126)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249410
PNG
(US9434697, 127 | US9730931, Compound 127)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249435
PNG
(US9434697, 156 | US9730931, Compound 156)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)
PDB

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n/an/a<1n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249442
PNG
(US9434697, 163 | US9730931, Compound 163)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249443
PNG
(US9434697, 164 | US9730931, Compound 164)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249399
PNG
(US9434697, 112 | US9730931, Compound 112)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249403
PNG
(US9434697, 120 | US9730931, Compound 120)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249404
PNG
(US9434697, 121 | US9730931, Compound 121)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249405
PNG
(US9434697, 122 | US9730931, Compound 122)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249415
PNG
(US9434697, 132 | US9730931, Compound 132)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249431
PNG
(US9434697, 151 | US9730931, Compound 151)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249433
PNG
(US9434697, 154 | US9730931, Compound 154)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249437
PNG
(US9434697, 158 | US9730931, Compound 158)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249445
PNG
(US9434697, 166 | US9730931, Compound 166)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249413
PNG
(US9434697, 130 | US9730931, Compound 130)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C29H26Cl2N6O4/c1-4-25(38)35-20-13-9-8-12-19(20)34-23-15-24(33-17-32-23)37(16-18-10-6-5-7-11-18)29(39)36-28-26(30)21(40-2)14-22(41-3)27(28)31/h4-15,17H,1,16H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249422
PNG
(US9434697, 141 | US9730931, Compound 141)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H35ClN8O4/c1-6-27(39)34-22-14-19(38-12-10-37(7-2)11-13-38)8-9-21(22)33-25-17-26(32-18-31-25)36(3)29(40)35-23-15-20(41-4)16-24(42-5)28(23)30/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333515
PNG
(US9730931, Compound 171)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8-
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249402
PNG
(US9434697, 116 | US9730931, Compound 116)
Show SMILES COCCN(C(=O)Nc1c(Cl)c(OC)cc(OC)c1Cl)c1cc(Nc2ccccc2NC(=O)C=C)ncn1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-5-21(34)31-16-9-7-6-8-15(16)30-19-13-20(29-14-28-19)33(10-11-36-2)25(35)32-24-22(26)17(37-3)12-18(38-4)23(24)27/h5-9,12-14H,1,10-11H2,2-4H3,(H,31,34)(H,32,35)(H,28,29,30)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249416
PNG
(US9434697, 133 | US9730931, Compound 133)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-19-9-8-18(39-12-10-38(7-2)11-13-39)14-20(19)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249420
PNG
(US9434697, 139 | US9730931, Compound 139)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H36N8O4/c1-6-28(38)34-25-16-21(37-12-10-36(7-2)11-13-37)8-9-24(25)33-26-18-27(31-19-30-26)35(3)29(39)32-20-14-22(40-4)17-23(15-20)41-5/h6,8-9,14-19H,1,7,10-13H2,2-5H3,(H,32,39)(H,34,38)(H,30,31,33)
PDB

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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249448
PNG
(US9434697, 170 | US9434697, 171 | US9730931, Compo...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
PDB

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n/an/a 8n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249424
PNG
(US9434697, 143 | US9730931, Compound 143)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2F)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34F2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249450
PNG
(US9434697, 172 | US9730931, Compound 172)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5-
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249455
PNG
(US9434697, 185 | US9730931, Compound 185)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(F)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)30-21-12(26)7-6-8-13(21)29-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 13n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249432
PNG
(US9434697, 152 | US9730931, Compound 152)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)37(3)21-15-19(40-13-11-39(8-2)12-14-40)9-10-20(21)35-24-17-25(34-18-33-24)38(4)30(42)36-29-27(31)22(43-5)16-23(44-6)28(29)32/h7,9-10,15-18H,1,8,11-14H2,2-6H3,(H,36,42)(H,33,34,35)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249451
PNG
(US9434697, 175 | US9730931, Compound 175)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(C)=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-13(2)23(33)30-15-9-7-6-8-14(15)29-18-11-19(28-12-27-18)32(3)24(34)31-22-20(25)16(35-4)10-17(36-5)21(22)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249397
PNG
(US9434697, 110 | US9730931, Compound 110)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(F)=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-12(26)22(33)30-14-8-6-5-7-13(14)29-17-10-18(28-11-27-17)32(2)23(34)31-21-19(24)15(35-3)9-16(36-4)20(21)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249411
PNG
(US9434697, 128 | US9730931, Compound 128)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#CC)ncn2)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h6-7,9-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249401
PNG
(US9434697, 114 | US9730931, Compound 114)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249412
PNG
(US9434697, 129 | US9730931, Compound 129)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5+
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249454
PNG
(US9434697, 184 | US9730931, Compound 184)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(C)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)30-22-13(2)8-7-9-14(22)29-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249425
PNG
(US9434697, 144 | US9730931, Compound 144)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249418
PNG
(US9434697, 136 | US9730931, Compound 136)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cc(C)no2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H25Cl2N7O5/c1-5-23(37)33-18-9-7-6-8-17(18)32-21-12-22(31-14-30-21)36(13-16-10-15(2)35-41-16)27(38)34-26-24(28)19(39-3)11-20(40-4)25(26)29/h5-12,14H,1,13H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249438
PNG
(US9434697, 159 | US9730931, Compound 159)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249436
PNG
(US9434697, 157 | US9730931, Compound 157)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249424
PNG
(US9434697, 143 | US9730931, Compound 143)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2F)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34F2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249407
PNG
(US9434697, 124 | US9730931, Compound 124)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 173n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249453
PNG
(US9434697, 183 | US9730931, Compound 183)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCNC(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)34-18-10-8-7-9-17(18)33-21-14-22(32-15-31-21)36(12-11-30-16(2)3)27(38)35-26-24(28)19(39-4)13-20(40-5)25(26)29/h6-10,13-16,30H,1,11-12H2,2-5H3,(H,34,37)(H,35,38)(H,31,32,33)
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n/an/a 180n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249431
PNG
(US9434697, 151 | US9730931, Compound 151)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 197n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249394
PNG
(US9434697, 105 | US9730931, Compound 105)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c(Cl)c(OC)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-5-21(31)28-16-9-7-6-8-15(16)27-19-12-20(26-13-25-19)30(2)23(32)29-17-10-14(33-3)11-18(34-4)22(17)24/h5-13H,1H2,2-4H3,(H,28,31)(H,29,32)(H,25,26,27)
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n/an/a 201n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249452
PNG
(US9434697, 181 | US9730931, Compound 181)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1
Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249432
PNG
(US9434697, 152 | US9730931, Compound 152)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)37(3)21-15-19(40-13-11-39(8-2)12-14-40)9-10-20(21)35-24-17-25(34-18-33-24)38(4)30(42)36-29-27(31)22(43-5)16-23(44-6)28(29)32/h7,9-10,15-18H,1,8,11-14H2,2-6H3,(H,36,42)(H,33,34,35)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249405
PNG
(US9434697, 122 | US9730931, Compound 122)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249456
PNG
(US9434697, 186 | US9730931, Compound 186)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(OC)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)30-22-13(8-7-9-14(22)35-3)29-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 345n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249415
PNG
(US9434697, 132 | US9730931, Compound 132)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 513n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249442
PNG
(US9434697, 163 | US9730931, Compound 163)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 519n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249409
PNG
(US9434697, 126 | US9730931, Compound 126)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249400
PNG
(US9434697, 113 | US9730931, Compound 113)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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n/an/a 621n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249439
PNG
(US9434697, 160 | US9730931, Compound 160)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249393
PNG
(US9434697, 103 | US9730931, Compound 103)
Show SMILES COc1cccc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C22H21ClN6O3/c1-4-20(30)27-15-9-6-5-8-14(15)26-18-12-19(25-13-24-18)29(2)22(31)28-16-10-7-11-17(32-3)21(16)23/h4-13H,1H2,2-3H3,(H,27,30)(H,28,31)(H,24,25,26)
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n/an/a 673n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249395
PNG
(US9434697, 107 | US9730931, Compound 107)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249433
PNG
(US9434697, 154 | US9730931, Compound 154)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)
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n/an/a 777n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249392
PNG
(US9434697, 102 | US9730931, Compound 102)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-5-22(30)28-19-9-7-6-8-18(19)27-20-13-21(25-14-24-20)29(2)23(31)26-15-10-16(32-3)12-17(11-15)33-4/h5-14H,1H2,2-4H3,(H,26,31)(H,28,30)(H,24,25,27)
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n/an/a 853n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4 C., or for 1 hour at room temperature. Following pre-incubatio...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249404
PNG
(US9434697, 121 | US9730931, Compound 121)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 1.02E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249447
PNG
(US9434697, 168 | US9730931, Compound 168)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
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n/an/a 1.03E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249414
PNG
(US9434697, 131 | US9730931, Compound 131)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a 1.17E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249403
PNG
(US9434697, 120 | US9730931, Compound 120)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 1.19E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249398
PNG
(US9434697, 111 | US9730931, Compound 111)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
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n/an/a 1.28E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249411
PNG
(US9434697, 128 | US9730931, Compound 128)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#CC)ncn2)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h6-7,9-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 1.68E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249435
PNG
(US9434697, 156 | US9730931, Compound 156)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a 1.95E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 1.98E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100 | US9730931, Compound 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a 1.98E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108 | US9730931, Compound 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 2.00E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249417
PNG
(US9434697, 135 | US9730931, Compound 135)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 2.03E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249437
PNG
(US9434697, 158 | US9730931, Compound 158)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)
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n/an/a 2.15E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249426
PNG
(US9434697, 145 | US9730931, Compound 145)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)
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n/an/a 2.19E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249430
PNG
(US9434697, 150 | US9730931, Compound 150)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)
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n/an/a 2.29E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249399
PNG
(US9434697, 112 | US9730931, Compound 112)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249440
PNG
(US9434697, 161 | US9730931, Compound 161)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 2.69E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249408
PNG
(US9434697, 125 | US9730931, Compound 125)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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n/an/a 2.86E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249410
PNG
(US9434697, 127 | US9730931, Compound 127)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 3.20E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249443
PNG
(US9434697, 164 | US9730931, Compound 164)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a 3.51E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249406
PNG
(US9434697, 123 | US9730931, Compound 123)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 3.89E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM333515
PNG
(US9730931, Compound 171)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8-
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n/an/a 3.92E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100 | US9730931, Compound 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a 4.18E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249445
PNG
(US9434697, 166 | US9730931, Compound 166)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a 4.92E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249427
PNG
(US9434697, 147 | US9730931, Compound 147)
Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)
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n/an/a 5.94E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249453
PNG
(US9434697, 183 | US9730931, Compound 183)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCNC(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)34-18-10-8-7-9-17(18)33-21-14-22(32-15-31-21)36(12-11-30-16(2)3)27(38)35-26-24(28)19(39-4)13-20(40-5)25(26)29/h6-10,13-16,30H,1,11-12H2,2-5H3,(H,34,37)(H,35,38)(H,31,32,33)
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n/an/a 6.21E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249428
PNG
(US9434697, 148 | US9730931, Compound 148)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)
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n/an/a 6.44E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249454
PNG
(US9434697, 184 | US9730931, Compound 184)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(C)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)30-22-13(2)8-7-9-14(22)29-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 6.48E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249450
PNG
(US9434697, 172 | US9730931, Compound 172)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5-
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n/an/a 7.37E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249444
PNG
(US9434697, 165 | US9730931, Compound 165)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a 7.37E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249429
PNG
(US9434697, 149 | US9730931, Compound 149)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)
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n/an/a 7.70E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249434
PNG
(US9434697, 155 | US9730931, Compound 155)
Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a 8.03E+3n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249419
PNG
(US9434697, 137 | US9730931, Compound 137)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cc(CCN(C)C)ccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-17-9-8-16(10-11-35(2)3)12-18(17)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249413
PNG
(US9434697, 130 | US9730931, Compound 130)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C29H26Cl2N6O4/c1-4-25(38)35-20-13-9-8-12-19(20)34-23-15-24(33-17-32-23)37(16-18-10-6-5-7-11-18)29(39)36-28-26(30)21(40-2)14-22(41-3)27(28)31/h4-15,17H,1,16H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249392
PNG
(US9434697, 102 | US9730931, Compound 102)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-5-22(30)28-19-9-7-6-8-18(19)27-20-13-21(25-14-24-20)29(2)23(31)26-15-10-16(32-3)12-17(11-15)33-4/h5-14H,1H2,2-4H3,(H,26,31)(H,28,30)(H,24,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249451
PNG
(US9434697, 175 | US9730931, Compound 175)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(C)=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-13(2)23(33)30-15-9-7-6-8-14(15)29-18-11-19(28-12-27-18)32(3)24(34)31-22-20(25)16(35-4)10-17(36-5)21(22)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249448
PNG
(US9434697, 170 | US9434697, 171 | US9730931, Compo...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249446
PNG
(US9434697, 167 | US9730931, Compound 167)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100 | US9730931, Compound 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249423
PNG
(US9434697, 142 | US9730931, Compound 142)
Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249416
PNG
(US9434697, 133 | US9730931, Compound 133)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-19-9-8-18(39-12-10-38(7-2)11-13-39)14-20(19)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249412
PNG
(US9434697, 129 | US9730931, Compound 129)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5+
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249393
PNG
(US9434697, 103 | US9730931, Compound 103)
Show SMILES COc1cccc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C22H21ClN6O3/c1-4-20(30)27-15-9-6-5-8-14(15)26-18-12-19(25-13-24-18)29(2)22(31)28-16-10-7-11-17(32-3)21(16)23/h4-13H,1H2,2-3H3,(H,27,30)(H,28,31)(H,24,25,26)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249455
PNG
(US9434697, 185 | US9730931, Compound 185)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(F)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)30-21-12(26)7-6-8-13(21)29-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249441
PNG
(US9434697, 162 | US9730931, Compound 162)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249456
PNG
(US9434697, 186 | US9730931, Compound 186)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(OC)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)30-22-13(8-7-9-14(22)35-3)29-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249394
PNG
(US9434697, 105 | US9730931, Compound 105)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c(Cl)c(OC)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-5-21(31)28-16-9-7-6-8-15(16)27-19-12-20(26-13-25-19)30(2)23(32)29-17-10-14(33-3)11-18(34-4)22(17)24/h5-13H,1H2,2-4H3,(H,28,31)(H,29,32)(H,25,26,27)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100 | US9730931, Compound 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249402
PNG
(US9434697, 116 | US9730931, Compound 116)
Show SMILES COCCN(C(=O)Nc1c(Cl)c(OC)cc(OC)c1Cl)c1cc(Nc2ccccc2NC(=O)C=C)ncn1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-5-21(34)31-16-9-7-6-8-15(16)30-19-13-20(29-14-28-19)33(10-11-36-2)25(35)32-24-22(26)17(37-3)12-18(38-4)23(24)27/h5-9,12-14H,1,10-11H2,2-4H3,(H,31,34)(H,32,35)(H,28,29,30)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249421
PNG
(US9434697, 140 | US9730931, Compound 140)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)cccc2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-4-25(38)33-22-15-18(37-13-11-36(5-2)12-14-37)9-10-21(22)32-23-16-24(31-17-30-23)35(3)27(39)34-26-19(28)7-6-8-20(26)29/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,38)(H,34,39)(H,30,31,32)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249422
PNG
(US9434697, 141 | US9730931, Compound 141)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H35ClN8O4/c1-6-27(39)34-22-14-19(38-12-10-37(7-2)11-13-38)8-9-21(22)33-25-17-26(32-18-31-25)36(3)29(40)35-23-15-20(41-4)16-24(42-5)28(23)30/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249420
PNG
(US9434697, 139 | US9730931, Compound 139)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H36N8O4/c1-6-28(38)34-25-16-21(37-12-10-36(7-2)11-13-37)8-9-24(25)33-26-18-27(31-19-30-26)35(3)29(39)32-20-14-22(40-4)17-23(15-20)41-5/h6,8-9,14-19H,1,7,10-13H2,2-5H3,(H,32,39)(H,34,38)(H,30,31,33)
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EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249397
PNG
(US9434697, 110 | US9730931, Compound 110)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(F)=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-12(26)22(33)30-14-8-6-5-7-13(14)29-17-10-18(28-11-27-17)32(2)23(34)31-21-19(24)15(35-3)9-16(36-4)20(21)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



EISAI R&D Management Co., Ltd.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...


US Patent US9730931 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%